KR101815307B1 - 5-ht4 수용체 효능제로서 5-아미노-퀴놀린-8-카르복사미드 유도체 - Google Patents

5-ht4 수용체 효능제로서 5-아미노-퀴놀린-8-카르복사미드 유도체 Download PDF

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KR101815307B1
KR101815307B1 KR1020157030158A KR20157030158A KR101815307B1 KR 101815307 B1 KR101815307 B1 KR 101815307B1 KR 1020157030158 A KR1020157030158 A KR 1020157030158A KR 20157030158 A KR20157030158 A KR 20157030158A KR 101815307 B1 KR101815307 B1 KR 101815307B1
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amino
methyl
carboxamide
quinoline
piperidinyl
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KR20160004274A (ko
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라마크리쉬나 니로기
아닐 카르바리 쉰데
벤카테스와를루 자스티
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수벤 라이프 사이언시스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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KR1020157030158A 2013-03-20 2013-10-18 5-ht4 수용체 효능제로서 5-아미노-퀴놀린-8-카르복사미드 유도체 Expired - Fee Related KR101815307B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1199/CHE/2013 2013-03-20
PCT/IN2013/000639 WO2014147636A1 (en) 2013-03-20 2013-10-18 5-amino-quinoline-8-carboxamide derivatives as 5-ht4 receptor agonists
IN1199CH2013 IN2013CH01199A (cg-RX-API-DMAC10.html) 2013-03-20 2013-10-18

Publications (2)

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KR20160004274A KR20160004274A (ko) 2016-01-12
KR101815307B1 true KR101815307B1 (ko) 2018-01-04

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KR1020157030158A Expired - Fee Related KR101815307B1 (ko) 2013-03-20 2013-10-18 5-ht4 수용체 효능제로서 5-아미노-퀴놀린-8-카르복사미드 유도체

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US (1) US9790211B2 (cg-RX-API-DMAC10.html)
EP (1) EP2976337B1 (cg-RX-API-DMAC10.html)
JP (1) JP6185650B2 (cg-RX-API-DMAC10.html)
KR (1) KR101815307B1 (cg-RX-API-DMAC10.html)
CN (1) CN105164119B (cg-RX-API-DMAC10.html)
AP (1) AP2015008742A0 (cg-RX-API-DMAC10.html)
AU (1) AU2013382944B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015024060A2 (cg-RX-API-DMAC10.html)
CA (1) CA2907620C (cg-RX-API-DMAC10.html)
DK (1) DK2976337T3 (cg-RX-API-DMAC10.html)
EA (1) EA029365B1 (cg-RX-API-DMAC10.html)
ES (1) ES2674993T3 (cg-RX-API-DMAC10.html)
IN (1) IN2013CH01199A (cg-RX-API-DMAC10.html)
MX (1) MX364929B (cg-RX-API-DMAC10.html)
NZ (1) NZ712369A (cg-RX-API-DMAC10.html)
SG (1) SG11201507763RA (cg-RX-API-DMAC10.html)
WO (1) WO2014147636A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201506804B (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406434B (zh) * 2015-02-13 2020-09-11 苏文生命科学有限公司 作为5-ht4受体激动剂的酰胺化合物
CN109444301A (zh) * 2018-12-18 2019-03-08 江苏省中医院 一种测定血浆中普芦卡必利浓度的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099305A1 (en) * 2010-02-12 2011-08-18 Raqualia Pharma Inc. 5-ht4 receptor agonists for the treatment of dementia

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US5708174A (en) 1992-03-12 1998-01-13 Smithkline Beecham P.L.C. Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists
US5705498A (en) 1992-11-05 1998-01-06 Smithkline Beecham Plc. Piperidine derivatives as 5-HT4 receptor antagonists
FR2756564B1 (fr) * 1996-12-04 2004-05-14 Synthelabo Derives d'acide quinoleine-8-carboxylique, leur preparation et leur application en therapeutique
WO2001095903A1 (en) * 2000-06-15 2001-12-20 Respiratorius Ab 5-ht3 receptor antagonists for treatment of disorders involving airway constriction
JP4688799B2 (ja) * 2003-06-19 2011-05-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５ｈｔ４−拮抗性４−（アミノメチル）−ピペリジンベンズアミド
ES2338882T3 (es) 2003-11-24 2010-05-13 Pfizer, Inc. Compuestos de acido quinolona-carboxilico que tienen actividad agonista del receptor 5-ht4.
WO2005061483A2 (en) 2003-12-23 2005-07-07 Bio-Medisinsk Innovasjon As Modulators of peripheral 5-ht receptors
WO2005092882A1 (en) * 2004-03-01 2005-10-06 Pfizer Japan, Inc. 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
US8816090B2 (en) 2005-02-25 2014-08-26 Pfizer Inc. Benzisoxazole derivatives
WO2007010390A1 (en) 2005-07-22 2007-01-25 Pfizer Japan Inc. Indazolecarboxamide derivatives as 5ht4 receptor agonists
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
KR20120123089A (ko) 2010-02-16 2012-11-07 화이자 인코포레이티드 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099305A1 (en) * 2010-02-12 2011-08-18 Raqualia Pharma Inc. 5-ht4 receptor agonists for the treatment of dementia

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MX364929B (es) 2019-05-14
JP6185650B2 (ja) 2017-08-23
AU2013382944A1 (en) 2015-10-08
CN105164119B (zh) 2017-12-08
EP2976337B1 (en) 2018-05-02
EP2976337A1 (en) 2016-01-27
JP2016516089A (ja) 2016-06-02
US20160280694A1 (en) 2016-09-29
EA201591844A1 (ru) 2016-08-31
SG11201507763RA (en) 2015-10-29
CA2907620A1 (en) 2014-09-25
IN2013CH01199A (cg-RX-API-DMAC10.html) 2015-08-14
NZ712369A (en) 2016-11-25
CA2907620C (en) 2018-03-13
KR20160004274A (ko) 2016-01-12
DK2976337T3 (en) 2018-07-16
AP2015008742A0 (en) 2015-09-30
EA029365B1 (ru) 2018-03-30
ZA201506804B (en) 2016-07-27
ES2674993T3 (es) 2018-07-05
MX2015012350A (es) 2016-05-09
AU2013382944B2 (en) 2016-08-04
WO2014147636A8 (en) 2014-12-04
HK1217483A1 (zh) 2017-01-13
WO2014147636A1 (en) 2014-09-25
CN105164119A (zh) 2015-12-16
US9790211B2 (en) 2017-10-17
BR112015024060A2 (pt) 2017-07-18

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