KR101782174B1 - 한정된 이성체 함량을 갖는 디케토피페라진 마이크로입자 - Google Patents

한정된 이성체 함량을 갖는 디케토피페라진 마이크로입자 Download PDF

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KR101782174B1
KR101782174B1 KR1020127000804A KR20127000804A KR101782174B1 KR 101782174 B1 KR101782174 B1 KR 101782174B1 KR 1020127000804 A KR1020127000804 A KR 1020127000804A KR 20127000804 A KR20127000804 A KR 20127000804A KR 101782174 B1 KR101782174 B1 KR 101782174B1
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fdkp
microparticles
isomer content
trans isomer
insulin
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Korean (ko)
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KR20120044971A (ko
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켈리 에스 크래프트
칼라 서머빌
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맨카인드 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020127000804A 2009-06-12 2010-06-11 한정된 이성체 함량을 갖는 디케토피페라진 마이크로입자 Active KR101782174B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18677909P 2009-06-12 2009-06-12
US61/186,779 2009-06-12
PCT/US2010/038287 WO2010144785A2 (en) 2009-06-12 2010-06-11 Diketopiperazine microparticles with defined isomer contents

Publications (2)

Publication Number Publication Date
KR20120044971A KR20120044971A (ko) 2012-05-08
KR101782174B1 true KR101782174B1 (ko) 2017-09-26

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KR1020127000804A Active KR101782174B1 (ko) 2009-06-12 2010-06-11 한정된 이성체 함량을 갖는 디케토피페라진 마이크로입자

Country Status (17)

Country Link
US (1) US8227409B2 (cg-RX-API-DMAC7.html)
EP (2) EP2440186B1 (cg-RX-API-DMAC7.html)
JP (2) JP5859432B2 (cg-RX-API-DMAC7.html)
KR (1) KR101782174B1 (cg-RX-API-DMAC7.html)
CN (1) CN102458371B (cg-RX-API-DMAC7.html)
AR (1) AR077087A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010259939B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1010722B1 (cg-RX-API-DMAC7.html)
CA (1) CA2765156C (cg-RX-API-DMAC7.html)
ES (2) ES2880102T3 (cg-RX-API-DMAC7.html)
IL (1) IL216910A (cg-RX-API-DMAC7.html)
MX (1) MX2011013313A (cg-RX-API-DMAC7.html)
MY (1) MY172858A (cg-RX-API-DMAC7.html)
RU (1) RU2490026C1 (cg-RX-API-DMAC7.html)
SG (4) SG10201403147SA (cg-RX-API-DMAC7.html)
TW (1) TWI513692B (cg-RX-API-DMAC7.html)
WO (1) WO2010144785A2 (cg-RX-API-DMAC7.html)

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JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
US20070027063A1 (en) * 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
ES2302448B1 (es) * 2006-10-20 2009-05-08 Vodafone España, S.A. Sistema y metodo de difusion de informacion de area en entornos locales de tamaño reducido dentro de un sistema celular de comunicaciones moviles.
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
AU2010259943C1 (en) 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
JP5964304B2 (ja) 2010-08-25 2016-08-03 エータイアー ファーマ， インコーポレイテッド チロシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
EP2714094B1 (en) 2011-06-02 2016-02-24 The University of Louisville Research Foundation, Inc. Anti-nucleolin agent-conjugated nanoparticles
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
BR112015023168B1 (pt) * 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US9968125B2 (en) 2015-01-09 2018-05-15 Philip Morris Products S.A. Nicotine—diketopiperazine microparticle formulations and methods of making the same
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
IL260823B2 (en) * 2016-01-29 2024-08-01 Mannkind Corp Dry powder inhaler
WO2021202425A1 (en) 2020-03-28 2021-10-07 University Of Louisville Research Foundation, Inc. Methods of inhibiting or treating coronavirus infection, and methods for delivering an anti-nucleolin agent

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CN104383546B (zh) * 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
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Also Published As

Publication number Publication date
JP5859432B2 (ja) 2016-02-10
TWI513692B (zh) 2015-12-21
JP2016028068A (ja) 2016-02-25
ES2880102T3 (es) 2021-11-23
MX2011013313A (es) 2012-01-25
SG195546A1 (en) 2013-12-30
CN102458371A (zh) 2012-05-16
AU2010259939A1 (en) 2011-12-15
ES2751107T3 (es) 2020-03-30
SG176778A1 (en) 2012-01-30
CA2765156A1 (en) 2010-12-16
US8227409B2 (en) 2012-07-24
EP2440186B1 (en) 2019-08-07
TW201113259A (en) 2011-04-16
SG10201403147SA (en) 2014-10-30
IL216910A0 (en) 2012-02-29
CA2765156C (en) 2018-04-10
EP3556356A1 (en) 2019-10-23
BRPI1010722A2 (pt) 2016-03-15
SG10201706995VA (en) 2017-09-28
WO2010144785A3 (en) 2011-03-03
KR20120044971A (ko) 2012-05-08
IL216910A (en) 2016-05-31
EP3556356B1 (en) 2021-05-05
BRPI1010722B1 (pt) 2019-12-10
EP2440186A2 (en) 2012-04-18
MY172858A (en) 2019-12-12
JP6101326B2 (ja) 2017-03-22
CN102458371B (zh) 2015-08-05
AR077087A1 (es) 2011-08-03
RU2490026C1 (ru) 2013-08-20
RU2012100785A (ru) 2013-07-20
AU2010259939B2 (en) 2012-07-05
WO2010144785A2 (en) 2010-12-16
JP2012530062A (ja) 2012-11-29
US20100317574A1 (en) 2010-12-16

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