KR101781922B1 - 히스톤 탈아세틸효소(hdacs) 억제제 - Google Patents

히스톤 탈아세틸효소(hdacs) 억제제 Download PDF

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KR101781922B1
KR101781922B1 KR1020147031519A KR20147031519A KR101781922B1 KR 101781922 B1 KR101781922 B1 KR 101781922B1 KR 1020147031519 A KR1020147031519 A KR 1020147031519A KR 20147031519 A KR20147031519 A KR 20147031519A KR 101781922 B1 KR101781922 B1 KR 101781922B1
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oxo
dihydro
hydroxyacrylamide
ethyl
methyl
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KR20150000901A (ko
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지-왕 천
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페이-텍 창
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안지 파마슈티컬 코퍼레이션 리미티드
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
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  • Epidemiology (AREA)
  • Psychology (AREA)
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  • Oncology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Hematology (AREA)
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  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020147031519A 2012-04-10 2013-04-02 히스톤 탈아세틸효소(hdacs) 억제제 Active KR101781922B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622127P 2012-04-10 2012-04-10
US61/622,127 2012-04-10
PCT/US2013/035004 WO2013154870A1 (en) 2012-04-10 2013-04-02 Histone deacetylases (hdacs) inhibitors

Publications (2)

Publication Number Publication Date
KR20150000901A KR20150000901A (ko) 2015-01-05
KR101781922B1 true KR101781922B1 (ko) 2017-09-26

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US (2) US9387209B2 (enExample)
EP (1) EP2836484B1 (enExample)
JP (1) JP6258918B2 (enExample)
KR (1) KR101781922B1 (enExample)
CN (1) CN104364237B (enExample)
AU (1) AU2013246278B2 (enExample)
BR (1) BR112014025122B1 (enExample)
ES (1) ES2630062T3 (enExample)
IL (1) IL235053A (enExample)
IN (1) IN2014MN02104A (enExample)
RU (1) RU2629947C2 (enExample)
TW (1) TWI481597B (enExample)
WO (1) WO2013154870A1 (enExample)

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KR102014492B1 (ko) 2011-09-12 2019-08-26 어플라이드 머티어리얼스, 인코포레이티드 복합 플라스틱 부분들을 구비한 캐리어 헤드
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PL3052485T3 (pl) 2013-10-04 2022-02-28 Infinity Pharmaceuticals, Inc. Związki heterocykliczne i ich zastosowania
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015134973A1 (en) * 2014-03-07 2015-09-11 The Johns Hopkins University Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs)
CA2943075C (en) 2014-03-19 2023-02-28 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015153516A1 (en) * 2014-04-04 2015-10-08 University Of Florida Research Foundation Hdac inhibitor compounds and methods of treatment
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
NZ740616A (en) 2015-09-14 2023-05-26 Infinity Pharmaceuticals Inc Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA3063111C (en) * 2017-05-16 2022-10-11 Annji Pharmaceutical Co., Ltd. Histone deacetylases (hdacs) inhibitors
GB201820450D0 (en) 2018-12-14 2019-01-30 Z Factor Ltd Compound and its use for the treatment of alpha1-antitryspin deficiency
GB201918404D0 (en) * 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of aplha1-antitrypsin deficiency
KR20210116830A (ko) * 2020-03-17 2021-09-28 충북대학교 산학협력단 신규한 4-옥소퀴나졸린-기반 n-하이드록시프로펜아미드 및 이의 용도
CN111517977B (zh) * 2020-05-28 2023-05-23 爱斯特（成都）生物制药股份有限公司 一种合成2,4-二氟-3-三甲基乙酰胺基苯甲酸的方法
WO2021252475A1 (en) 2020-06-08 2021-12-16 Annji Pharmaceutical Co., Ltd. Quinazoline derivatives useful as selective hdac6 inhibitors
WO2023159155A1 (en) * 2022-02-18 2023-08-24 Pivalent Therapeutics, Inc. Inhibitors of phosphoinositide 3-kinase (pi3k) and uses thereof
WO2025029683A1 (en) 2023-07-28 2025-02-06 Cogent Biosciences, Inc. Pi3k inhibitors
WO2025085669A1 (en) * 2023-10-18 2025-04-24 Gilva Therapeutics Co., Ltd. Quinazolinone derivatives for hdac inhibition

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US9387209B2 (en) 2016-07-12
AU2013246278B2 (en) 2016-11-03
RU2014144142A (ru) 2016-06-10
EP2836484B1 (en) 2017-06-14
CN104364237B (zh) 2016-08-24
JP2015512939A (ja) 2015-04-30
KR20150000901A (ko) 2015-01-05
AU2013246278A1 (en) 2014-11-13
TW201345898A (zh) 2013-11-16
ES2630062T3 (es) 2017-08-17
CN104364237A (zh) 2015-02-18
IL235053A (en) 2017-09-28
WO2013154870A1 (en) 2013-10-17
IN2014MN02104A (enExample) 2015-09-04
JP6258918B2 (ja) 2018-01-10
US20130267542A1 (en) 2013-10-10
US9155739B2 (en) 2015-10-13
TWI481597B (zh) 2015-04-21
RU2629947C2 (ru) 2017-09-05
BR112014025122B1 (pt) 2022-08-16
EP2836484A1 (en) 2015-02-18
BR112014025122A2 (pt) 2021-07-06
EP2836484A4 (en) 2015-09-02
US20150196563A1 (en) 2015-07-16

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