KR101738605B1 - A composition comprising medical herbs for improving skin problem and manufacturing method thereof - Google Patents

Abstract

According to the present invention, there is provided a composition for improving skin diseases comprising an extract of a mixed medicinal herb consisting of a windbreak, a ginseng, a wisteria, a ginseng, a ginseng, a ginseng, a ginseng, a raw ginseng, a gypsum, a gypsum, According to the composition for improving skin diseases using the herbal medicines of the present invention and the method for preparing the same, the composition for improving skin diseases using the medicinal herb of the present invention is effective for treatment of skin diseases, especially atopic and acne, without any side effects.

Description

TECHNICAL FIELD The present invention relates to a composition for improving skin diseases using a medicinal herb,

The present invention relates to a composition for improving skin diseases comprising a medicinal herb extract and a process for producing the same.

The number of skin troubles and skin disease patients is continuously increasing due to environmental pollution, eating habits and genetic causes. In the United States, 5 ~ 12% of the whole population suffer from skin disease, and in Korea, about 200 ~ 3 million There are patients with skin diseases.

The most common skin diseases are atopic dermatitis, contact dermatitis, seborrheic dermatitis, urticaria, athlete's foot, rash, psoriasis, simple herpes zoster, dry skin, housewife eczema and acne.

Among the skin diseases, especially atopic dematitis (AD), chronic skin disease is a combination of genetic factors and environmental factors such as infection, food allergy or air antigen, and is associated with severe itching and eczema The incidence is high in developed countries such as the United States and France, and has a high incidence in infants and children in Korea.

In recent years, the rapid increase of the disease has been difficult to explain only by genetic sequencing, and the importance of environmental factors such as industrialization, residential type, westernization of eating habit and nuclear family has been emphasized, and the risk of exposure to various causes is increasing .

If atopic dermatitis patients are sensitized to specific antigens, they produce and control various factors in the human body. Macrophages, which are typical for inflammatory reactions, produce NO and various cytokines when they are infected with external factors , Secreted cytokine activates immune cells involved in inflammation.

In particular, in patients with atopic dermatitis, the production of immunoglobulin E (IgE) is characteristic and the expression of IgE-receptor is elevated. Excessive production of IgE stimulates mast cells by IgE-dependent histamine reactions leading to excessive histamine release.

Histamine causes severe itching, and secondary infections are caused by scratching of patients, resulting in inflammation and atopic dermatitis.

Nevertheless, most of the current therapeutic agents and remedies are steroids, which show serious side effects. Recently, immunosuppressive drugs have been developed, but no specific therapeutic agents or remedies have yet been developed that exhibit a cure effect without worrying about side effects .

In addition to steroids, there have been known examples of therapeutic agents for treating skin diseases by extracting active ingredients of herbal medicines currently known for their antiinflammatory or skin disease treatment effects. However, most of them have relieved itching and inflammation, There is a limit to its application.

Thus, herbal preparations for preventive or therapeutic purposes, which have little side effects and yet exhibit excellent effects, have not been developed, and most of the steroid preparations exhibiting serious side effects are used. In recent years, immunosuppressive agents have been developed and used as therapeutic agents for skin diseases. These agents have been known to have clinical effects due to immunosuppression, skin atrophy, inhibition of growth of children, capillary vasodilation, acne, There is a problem to be very careful in use.

Therefore, there is a need to develop a composition capable of effectively treating skin diseases such as atopy and acne without the side effects of solving the above-mentioned problems.

Korean Registered Patent No. 10-1238820 (Registered on Feb. 25, 2013) Korean Registered Patent No. 10-1270635 (Registered on May 31, 2013)

It is an object of the present invention to provide a composition for improving skin diseases and a method for producing the same, which is free from side effects by containing a herbal medicine which is effective for the prevention and treatment of skin diseases, particularly atopic and acne.

In order to attain the above object, the composition for improving skin diseases according to the present invention is characterized by comprising an extract of a mixed medicinal herb consisting of windblown, gossam, wisteria, angelica gigas, pickled ginseng, gypsum, raw persimmon, gypsum, white line, .

The composition for improving skin diseases according to the present invention may further comprise 1 to 10 parts by weight of a mixture of the herbal medicines extract of Braun, Gossam, Wisteria, Angelica keiskei, 1 ~ 10 parts by weight of corn steep liquor, 1 ~ 10 parts of corn steep liquor, 1 ~ 10 parts of corn steep liquor, 1 ~ 10 parts of corn steep liquor, 1 ~ 10 parts of corn steep liquor, 1 ~ 1 to 10 parts by weight of gypsum, 1 to 10 parts by weight of a white line, 1 to 10 parts by weight of a support, 1 to 10 parts by weight of a mold, and 1 to 10 parts by weight of a mint.

In addition, the skin disease-improving composition according to the present invention is characterized in that the extract of the mixed medicinal herb is obtained by hot water extraction.

In addition, the composition for improving skin diseases according to the present invention is characterized by being a tablet, a capsule, a pill or a solution.

In addition, the composition for improving skin diseases according to the present invention is characterized by having a therapeutic effect on atopy and acne.

According to the composition for improving skin diseases using the medicinal herb according to the present invention, the composition for improving skin diseases using the medicinal herb of the present invention is effective for treating the skin diseases, especially atopy and acne without any side effects.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a flowchart showing a method for producing a skin disease-improving composition by hot water extraction of the present invention.

The composition for improving skin diseases according to the present invention includes an extract of a mixed medicinal herb consisting of windblown, gosang, wisteria, angelica, senbetsu, kiwon, bamboo, bamboo leaf, gypsum, white pear, placer, mold and mint.

Herein, the herbal composition comprises 1 to 10 parts by weight of the above-mentioned windshield, 1 to 10 parts by weight of Gossam, 1 to 10 parts by weight of Gossamer, 1 to 10 parts by weight of Angelica keiskei, 1 to 10 parts by weight of Gossamer, 1 to 10 parts by weight 1 to 10 parts by weight of green tea beans, 1 to 10 parts by weight of green tea beans, 1 to 10 parts by weight of gypsum, 1 to 10 parts by weight of white line, 1 to 10 parts by weight of green tea, 1 to 10 parts by weight of molds, By weight of the extract in parts by weight.

Herein, the weight portion of each of the herbal ingredients is derived from the inventor of the present invention as the best practitioner through many years of clinical trials, and does not mean that the herbal composition is limited to the numerical value for the same or similar efficacy .

The weight ratio of each medicinal herb constituting the composition for improving skin diseases according to the present invention is limited on the basis of the improvement effect and the possibility of side effects. The upper limit value of the weight ratio range is determined considering the contents of other medicinal materials as a whole, There is a problem that the improvement effect of skin diseases (especially, atopic and acne) is lowered, and the weight ratio range of each herbal medicine constituting the composition according to the present invention is limited to the above-mentioned numerical range.

Next, the herbal medicine used in the composition for improving skin diseases will be briefly introduced.

The windshield (Saposhnikovia divaricata Schiskin: windbreak) is a medicinal windshield made of roots and rootstocks of mountain-type windshields and is a very important medicinal material for the treatment of windshields (winds disease). The windshield is cylindrical and the lower part is slightly thinner. The outer surface is light brown, and the upper part of the rootstock has dense wrinkles in the form of rounded nodules, and some of the hairy leaves of brown hair are attached. It is effective for all kinds of aphrodisias such as external headache, chills, fever, whole body and sore throat.

Sophorae Radix is a herbaceous perennial herbaceous rod (Sophora angustifolia S. et. Z) that has been dried by removing the cork layer from the roots (Kim Chang Min et al., Chinese Medicine Dictionary, Vol. 1, pp340- 347, 1997, published by Seongdam, Seoul), has been used for a long time as a placebo, intestinal hemorrhage, and hemorrhoids. In addition, various kinds of alkaloids, prenyl flavonoids, triterpene and the like components were separated from the ginseng, and the components were classified into antiarrhythmic activity, anti-ulcer activity, anti-asthmatic activity, antimicrobial activity, antiviral activity, Have been reported, and are effective in dermatitis, atopy, and acne.

Arcti Fructus is a seed of Arctium lappa Linne and contains arctin, raffol A, B, C, D and E (lappaol A, B, C, D and E) arctigenin and aractidic acid and has the effect of detoxification, quenching and drainage. It is often used for purulent boils and skin diseases, It is also applied to the treatment of cold, sore throat and tonsillitis.

Angelica gigas is a perennial herb belonging to Umbelliferae. It contains decursin, decursinol and imperatorin in the root of Angelica gigas Nakai, (风 風), blood (驅 瘀 血), blood (补血), 补血 (驅 瘀血), the gangjang (剛 肠), the landscape and the calm (鎭 静) is the efficacy.

It is called the retirement of the line, retirement, goodness, 蟬 甲, 蟬 및 and 蟬 蟬, and the taste is moon, It acts on the liver (liver) and lung (lung). The pharmacological effect heals the spine of children and treats dystocia (dystocia). Taking ashes of medicinal materials with water will cure old diarrhea, cure the occurrence of seizures in children with high fever, stop the thirst, and take a powder 1 (钱) with Junghwa (井 華 水). It is known to treat symptoms that do not exist.

Creation is a medicine that summarizes the drying of the rhizome of a multi-year-old herbaceous plant belonging to the Asteraceae family, and it is a summarizing remedy for the irritation of the abdomen.

The throat is a dry leaf of the forest of the dead tree which belongs to the vine of the vine of the shrubs. It contains 11 kinds of acne vine and is a medicinal substance with the effect of strengthened diuretic.

Rehmanniae Radix is a fresh roots of rhubarb or other scrophulariaceae, and it is found in the 渴渴渴 다음 다음 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 번 good.

Because gypsum removes the mood of lung from the lungs and helps blood 药 to detoxify the blood, it causes dyspepsia and eruption, It can be used for the spreading of the fever (肝热) to the blood (胆 血).

It refers to the roots of Dactamnus dasycarpus, a Rutaceae plant (Korean Pharmacopoeial Species (KHP), 2007). It is known that it can be used to treat symptoms such as skin rash, skin erosion, eczema, rubella, itching, jaundice, urinary tract, limb paralysis, seawater, throat drying,

The buddha is a mature fruit of the annual herbaceous Kochia scoparia SCHRAD. Belonging to the Chenopodiaceae. It dries when the fruit grows in autumn, and then removes the skin after drying. It has a little scent and a little bit of taste. Its main ingredient contains triterpenoid saponin and 15% essential oil, and the green part contains alkaloid. It is known that the supporters have diuretic action and inhibition of skin fungi such as blue fever, bruxism, and urinary incontinence.

The mold is a 1-year-old grass belonging to the Lamiaceae, and is cultivated nationwide as a medicinal plant originating in China. It is used as a bamboo shrimp (祛風 解 表), fever of the cold, throat dandruff, margin (measles), postpartum paralysis, hemorrhage, I also write.

Mint is a perennial grass belonging to the Lamiaceae. It is used as an antipyretic agent or as a dry noodle for peppermint, which is dried in the shade after the leaves of a good day. The menthol contained in the leaves is used as toothpaste, spices, It is widely used as a fragrance in beverages.

The inventors of the present invention have verified that as a result of several years of clinical trials, when each of the medicaments is used individually, it shows a more immediate and clear skin disease improvement effect when used in a specific combination.

It is judged that this is caused by the action of each component, that is, by raising the pharmacological effect of the components taken together, or supplementing the deficient part of the effect of the specific component. The results of the survey will be clear.

The composition of the present invention may be a pharmaceutical composition, and may be administered either orally or parenterally. The dosage form is not particularly limited, but will be determined depending on the age, sex, or the severity of the disease as well as the dosage form of the patient.

In addition, the composition of the present invention may be a health food for the prevention and treatment of skin diseases, especially atopic and acne. When the herbal extracts according to the present invention are used as a food additive, the herbal extracts may be directly added or used together with other food or food ingredients, and may be suitably used according to a conventional method. The amount of the active ingredient to be mixed may be suitably determined according to the purpose of use, that is, prevention, health, or therapeutic purpose, and may be in the form of tablets, capsules, pills, or liquids.

For example, a composition for improving skin diseases comprising an extract of a mixed medicinal herb comprising the above composition may be prepared by taking the medicinal herb and dissolving it in a polar solvent such as water, ethanol, butanol and methanol, and a polar solvent such as ether, hexane, benzene, chloroform and ethyl acetate Nonpolar solvent may be added and the mixture may be precipitated at room temperature or warm-extracted. Preferably, the composition of the present invention can be prepared by a hot water extraction method.

The hot water extraction method can be prepared by using a known method, but preferably it can be produced according to a flowchart showing a method for producing a skin disease improving composition by hot water extraction shown in FIG. As shown in the figure, the method for preparing a composition for improving skin diseases by hot water extraction according to the present invention comprises: 1 to 10 parts by weight of windshield, 1 to 10 parts by weight of ginseng, 1 to 10 parts by weight, 1 to 10 parts by weight of cordierite, 1 to 10 parts by weight of cordierite, 1 to 10 parts by weight of cordierite, 1 to 10 parts by weight of cordierite, 1 to 10 parts by weight of raw persimmon, 1 to 10 parts by weight of plaster, 1 to 10 parts by weight of a mold, and 1 to 10 parts by weight of a peppermint are mixed (S101).

The mixing ratios of the herbal medicines are preferably added as described above, but the amount of herbal medicines to be used may vary depending on the type of disease to be applied and the age of the user.

Next, the mixed mixture is prepared in a nonwoven fabric, put in a water bath containing water, and subjected to a circulating pressureless state (S102).

More specifically, the nonwoven fabric is a hot-water nonwoven fabric, which contains the herbal medicines, and the medicinal herbs are placed in a pottery containing 2 to 7 times of the extraction solvent (water) It is desirable to boil the water until the boiling point (100 ° C) is reached.

Further, it is preferable that boiling water is boiled for 2 to 4 hours in a weak fire until the active ingredient of herbal medicine is sufficiently extracted.

In addition, the step of filtering the drug (S103) provides a solution for improving skin diseases.

Hereinafter, the present invention will be described in detail on the basis of embodiments. The presented embodiments are illustrative and are not intended to limit the scope of the invention.

< Example >

As a medicinal herb, we prepared windblown, gosam, wisteria, angelica, chrysanthemum, chrysanthemum, thistle, balsam, gypsum, white line, branch, chisel and mint.

Each medicinal herb has about 10 g each of windbreak, gosam, raveler, angelica, elliptic, creation, throat, raw persimmon, gypsum, plaster, The size of the medicines prescribed in Article 19 of the "Pharmacopoeia" of the "Pharmacopoeia" was the same as the fraction of the "theft" and "powder".

Then, the medicinal materials were mixed and immersed in a nonwoven fabric, and then purified water corresponding to about 5 to 10 times the total medicinal capacity was placed in a pottery, and the nonwoven fabric containing the medicinal herb was immersed therein. Thereafter, It was in a state of pressure.

Then, the prepared medicinal material was boiled in water for a predetermined period of time, and the nonwoven fabric containing the medicinal herb was removed to obtain a bath liquid containing a composition for improving skin diseases.

< Test Example >

In order to evaluate the effect of atopic dermatitis on the improvement of atopic skin disease, 10 patients who were at least 20 years old were tested. The patients who agreed to the efficacy test were all suffering from atopic symptoms including erosion, fibrinolysis, redness, red spot, and itching. All the participants took the bath solution prepared in the above example.

At this time, as a rule, the bath solution is taken in a pack of 100 cc for about 30 minutes before the meal twice a day.

[Table 1]

As shown in the above table, the participants taking the bath solution prepared according to the Examples were mostly patients with erosive symptoms accompanied by most erosion, fibrinolytic acidosis, redness, red spot, and itching, and the sex, age , Atopic history, and symptom site. However, although there is a difference depending on the degree of atopic symptoms, the symptom is alleviated or cured as a result of the administration, so that the composition of the present invention is excellent in atopy treatment and relieving effect.

While the present invention has been particularly shown and described with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes, modifications, and variations may be made without departing from the spirit and scope of the invention as defined by the appended claims. Anyone with ordinary knowledge will know easily.

Claims (5)

1 to 10 parts by weight of gusts, 1 to 10 parts by weight of ginseng, 1 to 10 parts by weight of glutamate, 1 to 10 parts by weight of Angelica keiskei, 1 to 10 parts by weight of glutinous rice, 1 to 10 parts by weight of glutinous rice, 1 to 10 parts by weight of glutinous rice, 1 to 10 parts by weight of gypsum, 1 to 10 parts by weight of gypsum, 1 to 10 parts by weight of white line, 1 to 10 parts by weight of leaflet, 1 to 10 parts by weight of mold, and 1 to 10 parts by weight of peppermint A composition for relieving symptoms.
delete The method according to claim 1,
Wherein the extract of the mixed medicinal herb is obtained by hot water extraction.
The method according to claim 1,
Wherein the composition for alleviating atopic symptoms is a tablet, a capsule, a pill or a solution.
delete

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