CN106728092B

CN106728092B - Yi medicine composition

Info

Publication number: CN106728092B
Application number: CN201710118298.XA
Authority: CN
Inventors: 郝应芬
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-03-01
Filing date: 2017-03-01
Publication date: 2020-08-18
Anticipated expiration: 2037-03-01
Also published as: CN106728092A

Abstract

The invention provides a Yi medicine composition which comprises roots or whole plants of Potentilla cone-shaped flower column group multi-division plants and fruits of litsea deciduous plant. The medicinal composition has the outstanding effects of quickly relieving pain and stopping diarrhea, all the used raw medicinal materials are natural wild products, the resources are rich, the medicinal and edible sources are homologous, the medicinal and edible effects are safe and effective, the price is low, and the Yi medicine can obviously relieve pain and stop diarrhea within 30 minutes after being taken.

Description

Yi medicine composition

Technical Field

The invention relates to a Yi medicine composition, and belongs to the field of medicines.

Background

The gastrointestinal tract is the largest immune organ of the human body and also the largest toxin expelling organ of the human body. The gastrointestinal tract refers to the digestive tract from the stomach pylorus to the anus. The intestine is the longest segment of the digestive tract and is also the most functionally important segment. But often causes gastrointestinal disorders such as gastrointestinal colic, diarrhea, dysentery, etc. for a variety of reasons.

Diarrhea refers to the condition of frequent defecation, loose stool, even watery stool due to affection of exogenous pathogenic factors, or damage caused by food or drink, or emotional disorder, or weakness of the spleen and stomach, or insufficiency of both the spleen and kidney yang. Dysentery refers to the condition of frequent defecation, abdominal pain, tenesmus, red and white diarrhea and sticky stool. Dysentery and diarrhea are mostly caused in summer and autumn, the disease location is in the stomach and intestine, the etiology is similar, the symptoms are abdominal pain, the stool frequency is increased, but the dysentery has more and less stool frequency, the dysentery is red and purulent blood, and the abdominal pain is accompanied with tenesmus and serious tenesmus. The diarrhea is loose and thin, the stool is clear and thin, or like water, or the food is not melted, but there is no red, white, purulent and bloody stool, much abdominal pain accompanied by borborborygmus, and little tenesmus. Under certain conditions, the two diseases of diarrhea and dysentery can be mutually transformed, either diarrhea first and then dysentery, or diarrhea first and then dysentery.

In the Yi medicine field, gastrointestinal colic is called Yimo fruit (transliteration), diarrhea is called Yimo history, and dysentery is called Wuqi. There are some traditional prescriptions for treating gastrointestinal diseases in Yi medicine, but the current disclosures are less.

Disclosure of Invention

Based on the problems, the invention aims to provide a Yi medicine for treating gastrointestinal colic, diarrhea and dysentery, so as to relieve the gastrointestinal colic, the diarrhea and/or the dysentery of patients in the shortest period and better eliminate the pain and the harm to the health of the patients.

Specifically, the invention provides a pharmaceutical composition, which comprises the following raw materials in parts by weight: 5-20 parts of roots or whole plants of Potentilla cone-shaped floral pillar group multi-fission plants and 1-10 parts of litsea deciduous plant fruits.

In a specific embodiment of the present invention, the weight ratio is: 5-15 parts of roots or whole plants of Potentilla cone-shaped floral pillar group multi-fission plants and 1-10 parts of litsea deciduous plant fruits.

In another embodiment of the present invention, the weight ratio is: 7-13 parts of roots or whole plants of Potentilla cone-shaped floral pillar group multi-fission plants and 3-7 parts of litsea deciduous plant fruits.

In another embodiment of the present invention, the weight ratio is: 10 parts of roots or whole plants of the Potentilla cone-shaped floral pillar group multi-fission plant and 5 parts of fruits of the litsea deciduous plant.

Further, the raw materials of the material comprise the following components in parts by weight: 5-20 parts of roots or whole plants of the Potentilla cone-shaped cauliflower group multi-fission plant and 1-10 parts of litsea or fragrant litsea.

Wherein, the Potentilla cone-shaped floral pillar group multi-fission plant is selected from Potentilla chinensis Chinensisser, and has main effects of stopping bleeding and dysentery in Yi medicine; the Litsea deciduous leaf group plant is selected from at least one of Litsea euosma W.W.Smith, Litsea L.pungens Hemsl and Litsea mollis Hemsl, and has the main effect of guiding qi downward and relieving pain in Yi medicine.

However, the researches of the invention find that the potentilla chinensis has poor effects of stopping bleeding, stopping dysentery, guiding qi downward, relieving flatulence and relieving pain; the pungent litse fruit has strong qi-regulating and pain-relieving effects, and can quickly achieve the effects of regulating qi, relieving flatulence and relieving pain. The two medicinal materials have different effects, one of the two medicinal materials is used independently, and although the medicinal materials have certain treatment effect on gastrointestinal diseases such as diarrhea, gastrointestinal colic, dysentery and the like, the medicinal materials have slow effect and cannot relieve the disease condition of a patient at the first time, for example, abdominal pain and diarrhea caused by unknown reasons in one village, two groups (a certain cool) in Luogubei villages of Wenchang city, 60 years old, 2016, 10 months and 28 days are still not obvious after 30-60 min; but after the dried litsea pungens is added immediately, the abdominal pain and diarrhea are obviously relieved in about 10-20 min; after the medicine is taken twice continuously, the symptoms are completely eliminated. The cases are not individual, and at present, ten patients cannot obtain good treatment after independently taking potentilla chinensis or (one of litsea pungens, litsea pungens and litsea cubeba) at present, and the symptoms can be immediately relieved and cured as soon as possible after the inventor uses the two medicines in combination.

Therefore, the inventor combines the Yi traditional secret prescription and long-term medical practice, combines the Yi traditional secret prescription and the Yi traditional secret prescription, combines and uses the Yi traditional secret prescription and the Yi traditional secret prescription, has already treated the gastrointestinal colic and the diarrhea for thousands of cases in clinical application for many years, and has obvious curative effect, and the cure rate reaches more than 95%.

The pharmaceutical composition of one embodiment of the present invention: 15g of fresh root or 10g of dried root of Potentilla chinensis Ser. Fresh 10g or dried 5g of litseaouosma w.w.smith or litsea l.purenshemsl. Taking the 2 medicinal materials, chewing the fresh product, and grinding the dry product into powder for oral administration.

Typical cases using the Yi medicine are as follows:

(1) a certain old man, male, is 39 years old, Wenchang City in Sichuan province, has 10 months in 2016, has intermittent colic in the middle and upper abdomen, and has diarrhea stopping after taking the medicine orally for 1 time and 10 minutes.

(2) A certain sand horse, a woman, 71 years old, Sichuan Xingxing people in Xichang city of Sichuan province, 2015 for 6 months, because of going out to be drenched with rain, the clothes are not changed in time, namely the abdominal pain is discharged, 7-8 times a day, the effect is not good after taking the berberine tablet, the pain is obviously improved within 1 time and 30 minutes after the medicine is orally taken, the diarrhea is obviously weakened, and the diarrhea stops within 24 hours, so the patient is fully cured.

The medicinal composition has the outstanding effects of quickly relieving pain and stopping diarrhea, all the used raw medicinal materials are natural wild products, the resources are rich, the medicinal and edible sources are homologous, the medicinal and edible effects are safe and effective, the price is low, and the Yi medicine can obviously relieve pain and stop diarrhea within 30 minutes after being taken. Because of good analgesic effect, the medicine is locally praised as 'Western medicine 6542 (racanisodamine)' in the Yi region at present, and is suitable for patients with gastrointestinal colic and various diarrhea.

Meanwhile, based on the characteristics of quick response and good curative effect after the combination use, the invention also provides the application of the roots or the whole grass of the Potentilla cone-shaped flower column group multi-fission plant and the litsea deciduous leaf group plant fruits in preparing the medicines for treating gastrointestinal colic, diarrhea and/or dysentery by combined administration.

The combination administration is not limited to mixing the two into one preparation unit at the same time, and the two can be packaged separately, and when in use, the two can be taken simultaneously or sequentially.

On the basis of the composition, in order to further enhance the potency and efficacy of the formula of the composition or compensate for the pharmacological effects which the formula does not have, the following components can be added into the raw materials: at least one of rhizoma Acori Calami, rhizoma Polygoni Paleachi, folium Artemisiae Argyi, Scutellariae radix, cortex Phellodendri, radix aucklandiae, radix Pimpinellae Candolleanae, radix Rumicis Crispi, and radix Berberidis.

Wherein, the acorus calamus is the rhizome of acorus calamus of Araceae, and is used for aromatic and filth-avoiding, wind-dispelling, dampness-removing, cold-dispelling, qi-guiding, pain-relieving, diarrhea-checking, dysentery-stopping, etc. in Yi medicine; the rhizoma Polygoni Paleachi is selected from rhizome of Polygonum hydropiper Paleecum wall of Polygonum of Polygonaceae or Polygonum cirrhosa Sphaeranthum Meisn of Polygonum of the same genus, and can be used for promoting blood circulation, removing blood stasis, astringing intestine, and relieving dysentery in Yi medicine; the aged artemisia argyi is generally used for preserving more than one year of artemisia argyi and is used for warming stomach, dispelling wind, cold, guiding qi downward, relieving pain and the like in Yi medicine; the Scutellariae radix is dried root of Scutellaria baicalensis Georgi of Labiatae, and can be used for clearing pathogenic fire, removing toxic substance, eliminating dampness, promoting diuresis, relieving diarrhea, etc. in Yi medicine; cortex Phellodendri is dried bark of Phellodendron chinense Schneid. or Phellodendron amurense Rupr. of Rutaceae, and can be used for clearing heat, removing toxic substances, eliminating dampness, promoting urination, killing parasite, and relieving diarrhea; radix aucklandiae is dried root of Vladimiria souliei (Franch.) Ling of Compositae or Vladimiria souliei (Franch.) Ling var. cinerea Ling, and can be used for guiding qi downward, relieving pain, and invigorating stomach; the Valeriana jatamansi Jones is a dried rhizome and root of Valeriana jatamansi Jones of the Valerianaceae family, and is used for invigorating stomach, promoting digestion, dispelling wind, guiding qi downward, relieving pain and stopping diarrhea in Yi medicine; radix Rumicis Crispus L. root of Rumex crispus of Polygonaceae, and can be used for clearing away heat and toxic materials, eliminating dampness, relieving diarrhea, and relieving dysentery; berberis radix is root bark or stem bark of berberidaceae plant such as Berberis davidiana var, Berberis pubescens and Callicarpa schlegelii, and is used in Yi medicine for clearing pathogenic fire, removing toxic substance, eliminating dampness, relieving dysentery, and killing parasite.

The types and dosage of the above additional medicinal materials can be selected and adjusted according to specific diseases and conditions. The dosage range of each medicine can be but is not limited to: 1-10 parts of acorus calamus; 1-10 parts of rhizoma polygoni paleacei; 1-10 parts of aged moxa; 1-10 parts of scutellaria baicalensis; 1-10 parts of phellodendron; 1-10 parts of vladimiria root; 1-10 parts of valeriana jatamansi jones (water chestnut joss sticks); 1-10 parts of Rumex madaio Maxim; 1-10 parts of radix Berberidis.

The weight ratio of the invention is measured by dry products of all components. However, this should not be limited to the use of only dry products of the above components, and if fresh products (with a high water content), the dry product ratio can be converted to the fresh product amount by a conventional loss on drying test. For example, the invention has found in research that, in the raw materials picked during the experiment, 15g of fresh roots of potentilla corresponds to 10g of dry roots, and 10g of fresh fruits of litsea or litsea correspond to 5g of dry fruits.

The invention also provides a preparation method of the pharmaceutical composition, which comprises one of the following steps:

the method comprises the following steps: mixing the medicinal powders, and making into pharmaceutical composition without or with pharmaceutically acceptable adjuvants;

the second method comprises the following steps: extracting the above materials with water and/or ethanol, and making into pharmaceutical composition without adding pharmaceutically acceptable adjuvants and/or auxiliary components.

The invention also provides application of the pharmaceutical composition in preparing a medicament for treating gastrointestinal colic, diarrhea and/or dysentery.

As used herein, "pharmaceutically acceptable" is meant to include any material that does not interfere with the effectiveness of the biological activity of the active ingredient and is not toxic to the host to which it is administered.

The auxiliary materials are the general names of all the additional materials except the main medicine in the medicine preparation, and the auxiliary materials have the following properties: (1) no toxic effect on human body and few side effects; (2) the chemical property is stable and is not easily influenced by temperature, pH, storage time and the like; (3) has no incompatibility with the main drug, and does not influence the curative effect and quality inspection of the main drug; (4) does not interact with the packaging material.

The pharmaceutically acceptable auxiliary components have certain physiological activity, but the addition of the components does not change the dominance of the pharmaceutical composition in the process of treating diseases, but only plays an auxiliary effect, and the auxiliary effects are only the utilization of the known activity of the components and are auxiliary treatment modes which are commonly used in the field of medicine. If the auxiliary components are used in combination with the pharmaceutical composition of the present invention, the protection scope of the present invention should still be included.

Pharmaceutically acceptable adjuvants, such as cellulose and its derivatives (such as sodium carboxymethylcellulose, sodium ethylcellulose, cellulose acetate, etc.), gelatin, talc, solid lubricant (such as stearic acid, magnesium stearate), calcium sulfate, vegetable oil (such as soybean oil, sesame oil, peanut oil, olive oil, etc.), polyol (such as propylene glycol, glycerol, mannitol, sorbitol, etc.), emulsifier (such as Tween, etc.)

) Wetting agents (e.g., sodium lauryl sulfate), coloring agents, flavoring agents, stabilizers, antioxidants, preservatives, pyrogen-free water, and the like.

Wherein, the pharmaceutical composition is an oral administration preparation.

Of course, the mode of administration of the pharmaceutical composition of the present invention is not particularly limited, and topical administration may be used in addition to oral administration.

Solid dosage forms for oral administration include capsules, tablets, pills, powders, granules and the like, and are not limited to the above dosage forms. In these solid dosage forms, the raw material or extract is mixed with at least one conventional inert excipient (or carrier), such as sodium citrate or dicalcium phosphate, or with the following ingredients: (a) fillers or extenders, for example, starch, lactose, sucrose, glucose, mannitol and silicic acid; (b) binders, for example, hydroxymethylcellulose, alginates, gelatin, polyvinylpyrrolidone, sucrose and acacia; (c) humectants, for example, glycerol; (d) disintegrating agents, for example, agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain complex silicates, and sodium carbonate; (e) slow solvents, such as paraffin; (f) absorption accelerators, e.g., quaternary ammonium compounds; (g) wetting agents, such as cetyl alcohol and glycerol monostearate; (h) adsorbents, for example, kaolin; and (i) lubricants, for example, talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, or mixtures thereof. In capsules, tablets and pills, the dosage forms may also comprise buffering agents.

Solid dosage forms such as tablets, dragees, capsules, pills, and granules can be prepared using coatings and shells such as enteric coatings and other materials well known in the art. They may contain opacifying agents and the release of the active compound or compounds in such compositions may be delayed in release in a certain part of the digestive tract. Examples of embedding components which can be used are polymeric substances and wax-like substances. If desired, the material or extract may also be in microencapsulated form with one or more of the above excipients.

Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups or tinctures. In addition to the starting materials or extracts, the liquid dosage forms may contain inert diluents commonly employed in the art, such as water or other solvents, solubilizing agents and emulsifiers, e.g., ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, propylene glycol, 1, 3-butylene glycol, dimethylformamide, and oils, especially cottonseed, groundnut, corn germ, olive, castor and sesame oils, or mixtures of such materials, and the like.

In addition to these inert diluents, the compositions can also contain adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents. In addition to the starting materials or extracts, the suspensions may contain suspending agents, for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum methoxide and agar, or mixtures of these substances, and the like.

Dosage forms of the compositions of the present invention for topical administration include ointments, powders, patches, sprays, and inhalants. The active ingredient is mixed under sterile conditions with a physiologically acceptable carrier and any preservatives, buffers, or propellants which may be required if necessary.

The compounds of the present invention may be administered alone or in combination with other pharmaceutically acceptable agents.

The "A, B and/or C" of the present invention includes the following forms: (1) a, B, C, each used alone; (2) combinations of AB, AC, BC were used, respectively; (3) a combination of ABCs is used.

The water and the ethanol used in the invention are hydrous ethanol, the concentration of the ethanol is 5-95%, and for the medicinal materials, 50-95% v/v ethanol is usually used, such as 50-60%, 60-70%, 70-80%, 80-95% and the like. If the method adopts the hydrous ethanol for extraction, the method does not exclude the mode of gradient extraction, namely, firstly extracting by using high-concentration ethanol and then extracting by using low-concentration ethanol, thereby ensuring the complete extraction of the effective components.

Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.

Detailed Description

The foregoing aspects of the present invention are explained in further detail below with reference to specific embodiments. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Example 1 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. dried root 10 g. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.5 g. Pulverizing the above two materials, and mixing to obtain powder.

Example 2 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. dried root 200 g. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.10 g. Pulverizing the above two materials, and mixing to obtain powder.

Example 3 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. dried root 130 g. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.10 g. Decocting the two in water, and mixing the decoctions to obtain decoction.

Example 4 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. 50g dried root. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.10 g. Pulverizing the above two materials, mixing, and adding appropriate diluent to obtain powder.

Example 5 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. No. 20g dried root. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.5 g. Pulverizing the above two materials, mixing, and adding appropriate diluent to obtain powder.

Example 6 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. 70g dried root. Dried fruits of litseaouosmaw.w.smith or litsea l.pungenshensl.30 g of fragrant litsease. Pulverizing the above two materials, mixing, and adding appropriate diluent to obtain powder.

Example 6 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. dried root 130 g. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.70 g. Pulverizing the above two materials, mixing, and adding appropriate diluent to obtain powder.

Example 7 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. 70g dried root. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.70 g. Pulverizing the above two materials, mixing, and adding appropriate diluent to obtain powder.

Example 8 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. 1000g dried root. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.500 g. Mixing the two extracts, extracting with water for 2 times, mixing extractive solutions, concentrating under reduced pressure, adding appropriate amount of excipient and binder, and granulating.

Example 9 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. 1000g dried root. 1000g of dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl. Mixing the two, extracting with 60% v/v ethanol for 2 times, mixing extractive solutions, concentrating under reduced pressure, spray drying, adding appropriate amount of excipient and binder, and granulating.

Example 10 preparation of a pharmaceutical composition of the invention

Potentilla chinensis Ser. dried root 1300 g. Dried fruit of litseaouosmaw.w.smith or litsease l.punenshensl.300 g. Mixing the two solutions, extracting with 95% v/v ethanol for 2 times, and mixing the extractive solutions; extracting the residue with water for 2 times, and mixing the water extractive solutions; recovering ethanol from the ethanol extractive solution, mixing with the water extractive solution, concentrating under reduced pressure, standing, collecting supernatant, and adding appropriate amount of antiseptic to obtain oral liquid.

Claims

1. A pharmaceutical composition characterized by: the raw materials of the material comprise the following components in parts by weight:

7-13 parts of roots or whole plants of Potentilla cone-shaped floral pillar group multi-fission plants and 3-7 parts of litsea deciduous plant fruits;

the Potentilla cone rosette group multi-fission plant is selected from Potentilla chinensis Ser; the Litsea plant of the subgenus Litsea is selected from at least one of litseaeaeusma W.W.Smith, litseae L.pungens Hemsl, litseae mollis Hemsl.

2. The pharmaceutical composition of claim 1, wherein: the weight ratio is as follows: 10 parts of roots or whole plants of the Potentilla cone-shaped floral pillar group multi-fission plant and 5 parts of fruits of the litsea deciduous plant.

3. The pharmaceutical composition according to any one of claims 1 or 2, wherein: the pharmaceutical composition is an oral administration preparation.

4. A process for preparing a pharmaceutical composition according to claim 1, wherein: the method comprises one of the following steps:

the method comprises the following steps: mixing the medicinal powders, and making into pharmaceutical composition without or together with pharmaceutically acceptable adjuvants and/or auxiliary components;

5. Use of a pharmaceutical composition according to any one of claims 1 or 2 in the manufacture of a medicament for the treatment of gastrointestinal colic, diarrhea and/or dysentery.

6. Use of roots or whole herbs of plants of Potentilla cone-like floral pillar group and fruits of plants of Litsea deciduous subgenus for preparing a medicament for treating gastrointestinal colic, diarrhea and/or dysentery by combined administration;

wherein, the roots or the whole plants of the Potentilla cone-shaped floral pillar group multi-fission plant are 7 to 13 parts, and the fruits of the Litsea deciduous plant are 3 to 7 parts;