KR101738201B1 - 구토방지제로서의 아미설프라이드의 용도 - Google Patents

구토방지제로서의 아미설프라이드의 용도 Download PDF

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KR101738201B1
KR101738201B1 KR1020127024111A KR20127024111A KR101738201B1 KR 101738201 B1 KR101738201 B1 KR 101738201B1 KR 1020127024111 A KR1020127024111 A KR 1020127024111A KR 20127024111 A KR20127024111 A KR 20127024111A KR 101738201 B1 KR101738201 B1 KR 101738201B1
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vomiting
pharmaceutical composition
composition according
therapeutic pharmaceutical
amisulfide
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KR20130045241A (ko
Inventor
줄리안 클리브 길버트
로버트 윌리엄 그리스트우드
니콜라 쿠퍼
가브리엘 폭스
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아카시아 파마 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020127024111A 2010-03-11 2011-03-10 구토방지제로서의 아미설프라이드의 용도 Active KR101738201B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1004020.2A GB201004020D0 (en) 2010-03-11 2010-03-11 New therapeutic use
GB1004020.2 2010-03-11
PCT/GB2011/050472 WO2011110854A2 (en) 2010-03-11 2011-03-10 The use of amisulpride as an anti-emetic

Publications (2)

Publication Number Publication Date
KR20130045241A KR20130045241A (ko) 2013-05-03
KR101738201B1 true KR101738201B1 (ko) 2017-05-19

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KR1020127024111A Active KR101738201B1 (ko) 2010-03-11 2011-03-10 구토방지제로서의 아미설프라이드의 용도

Country Status (26)

Country Link
US (12) US8686019B2 (https=)
EP (3) EP2796171B1 (https=)
JP (2) JP5886213B2 (https=)
KR (1) KR101738201B1 (https=)
CN (1) CN102892407B (https=)
AU (1) AU2011225898B2 (https=)
BR (1) BR112012022746B1 (https=)
CA (1) CA2792392C (https=)
CY (3) CY1115485T1 (https=)
DK (3) DK2567690T3 (https=)
EA (1) EA030335B1 (https=)
ES (3) ES2665418T3 (https=)
GB (1) GB201004020D0 (https=)
HR (3) HRP20140744T1 (https=)
HU (1) HUE037088T2 (https=)
IL (1) IL221746A (https=)
LT (1) LT2796171T (https=)
MX (3) MX388787B (https=)
NO (1) NO2796171T3 (https=)
NZ (1) NZ602279A (https=)
PL (3) PL2544657T3 (https=)
PT (3) PT2544657E (https=)
RS (3) RS53467B (https=)
SI (3) SI2796171T1 (https=)
SM (3) SMT201800188T1 (https=)
WO (1) WO2011110854A2 (https=)

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GB201506116D0 (en) 2015-04-10 2015-05-27 Acacia Pharma Ltd Kit and combination therapy for nausea and vomiting
JP2018530744A (ja) 2015-09-02 2018-10-18 カリフォルニア インスティチュート オブ テクノロジー 低濃度の硫化水素ガスの分光学的検出のための方法および装置
GB201618425D0 (en) * 2016-11-01 2016-12-14 Acacia Pharma Ltd method
GB201702250D0 (en) * 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
KR20200110317A (ko) 2017-12-05 2020-09-23 선오비온 파마슈티컬스 인코포레이티드 결정형 및 이의 제조 방법
BR112020011189A2 (pt) 2017-12-05 2020-11-17 Sunovion Pharmaceuticals Inc. misturas não racêmicas e usos das mesmas
CA3142355A1 (en) 2019-06-04 2020-12-10 Sunovion Pharmaceuticals Inc. Modified release formulations and uses thereof
US20220323409A1 (en) * 2019-06-04 2022-10-13 Sunovion Pharmaceuticals Inc. Modified release formulations and uses thereof
KR20220041143A (ko) * 2019-07-31 2022-03-31 아스텔라스세이야쿠 가부시키가이샤 귀내 투여용의 의약 조성물
EP4175631A1 (en) 2020-07-06 2023-05-10 Acacia Pharma Ltd Therapy of post-operative nausea and vomiting
US20250206757A1 (en) 2022-03-21 2025-06-26 Gasherbrum Bio, Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
US20250250269A1 (en) 2022-04-14 2025-08-07 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
TW202435857A (zh) 2022-12-15 2024-09-16 美商迦舒布魯姆生物有限公司 具有glp-1促效劑活性之化合物之鹽及固體形式
JP2026501286A (ja) 2022-12-22 2026-01-14 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環式ｇｌｐ－１アゴニスト
WO2024131869A1 (en) 2022-12-22 2024-06-27 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
CN120957993A (zh) 2023-02-16 2025-11-14 加舒布鲁姆生物公司 杂环glp-1激动剂
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AR133240A1 (es) 2023-07-13 2025-09-10 Aconcagua Bio Inc Compuestos, composiciones y métodos
TW202519220A (zh) 2023-07-13 2025-05-16 美商雅空嘉閣生物公司 化合物、組合物及方法
WO2025045208A1 (en) 2023-08-31 2025-03-06 Gasherbrum Bio, Inc. Heteroaryl-heterocycloalkyl-based glp-1 agonists
WO2025137307A1 (en) 2023-12-20 2025-06-26 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2025171341A2 (en) 2024-02-08 2025-08-14 Aconcagua Bio, Inc. Compounds and compositions for treating conditions associated with calcitonin receptor and/or amylin receptor activity
WO2025171340A1 (en) 2024-02-08 2025-08-14 Aconcagua Bio, Inc. The treatment of calcitonin- and/or amylin-receptor associated conditions
TW202600132A (zh) 2024-03-08 2026-01-01 美商安尼波那生物公司 用於治療肥胖症及提高減重之方法
WO2026041075A1 (en) 2024-08-21 2026-02-26 Gasherbrum Bio, Inc. Gpl-1 agonists
WO2026051998A1 (en) 2024-09-04 2026-03-12 Aconcagua Bio, Inc. Compounds, compositions, and methods

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LT2796171T (lt) 2018-05-10
US10085970B2 (en) 2018-10-02
PT2567690E (pt) 2014-09-03
EP2544657A2 (en) 2013-01-16
NO2796171T3 (https=) 2018-06-30
PL2567690T3 (pl) 2014-11-28
US20210228543A1 (en) 2021-07-29
JP2013522181A (ja) 2013-06-13
IL221746A (en) 2017-03-30
PT2796171T (pt) 2018-04-24
NZ602279A (en) 2014-08-29
ES2665418T3 (es) 2018-04-25
PL2796171T3 (pl) 2018-07-31
WO2011110854A3 (en) 2011-11-10
US9545426B2 (en) 2017-01-17
JP6279526B2 (ja) 2018-02-14
US10525033B2 (en) 2020-01-07
SI2544657T1 (sl) 2014-12-31
CA2792392A1 (en) 2011-09-15
JP2016028090A (ja) 2016-02-25
EP2567690B1 (en) 2014-07-16
KR20130045241A (ko) 2013-05-03
CY1115485T1 (el) 2017-01-04
BR112012022746B1 (pt) 2021-09-28
HRP20140745T1 (hr) 2014-09-26
US9119836B2 (en) 2015-09-01
CN102892407A (zh) 2013-01-23
RS57032B1 (sr) 2018-05-31
MX2012010411A (es) 2012-11-30
DK2544657T3 (da) 2014-08-11
US9084765B2 (en) 2015-07-21
US9889118B2 (en) 2018-02-13
HRP20140744T1 (hr) 2014-09-26
US20150335616A1 (en) 2015-11-26
SI2796171T1 (en) 2018-05-31
CY1120170T1 (el) 2018-12-12
EP2544657B1 (en) 2014-07-16
MX388787B (es) 2025-03-20
ES2496099T3 (es) 2014-09-18
SI2567690T1 (sl) 2014-12-31
WO2011110854A2 (en) 2011-09-15
EA030335B1 (ru) 2018-07-31
PL2544657T3 (pl) 2014-10-31
GB201004020D0 (en) 2010-04-21
CY1115487T1 (el) 2017-01-04
BR112012022746A2 (pt) 2016-07-05
EP2796171B1 (en) 2018-01-31
PT2544657E (pt) 2014-09-03
US20250186394A1 (en) 2025-06-12
US20140147517A1 (en) 2014-05-29
DK2796171T3 (en) 2018-05-07
RS53466B (sr) 2014-12-31
JP5886213B2 (ja) 2016-03-16
EP2796171A1 (en) 2014-10-29
SMT201800188T1 (it) 2018-07-17
CN102892407B (zh) 2016-03-23
HRP20180436T1 (hr) 2018-05-04
US20180042896A1 (en) 2018-02-15
EP2567690A1 (en) 2013-03-13
HUE037088T2 (hu) 2018-08-28
AU2011225898B2 (en) 2014-07-03
SMT201400126B (it) 2015-05-05
DK2567690T3 (da) 2014-08-11
CA2792392C (en) 2018-06-19
RS53467B (sr) 2014-12-31
US20130022689A1 (en) 2013-01-24
US8686019B2 (en) 2014-04-01
US20200093792A1 (en) 2020-03-26
HK1179152A1 (zh) 2013-09-27
EA201290833A1 (ru) 2013-09-30
US20170087128A1 (en) 2017-03-30
MX370629B (es) 2019-12-18
US20220296570A1 (en) 2022-09-22
US20180353473A1 (en) 2018-12-13
ES2496092T3 (es) 2014-09-18
MX2019015396A (es) 2020-02-07
SMT201400127B (it) 2015-05-05
US12194022B2 (en) 2025-01-14
AU2011225898A1 (en) 2012-10-04
US20230144973A1 (en) 2023-05-11
US20130022688A1 (en) 2013-01-24

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