PL2567690T3 - Zastosowanie amisulprydu do leczenia pooperacyjnych nudności i wymiotów - Google Patents

Zastosowanie amisulprydu do leczenia pooperacyjnych nudności i wymiotów

Info

Publication number
PL2567690T3
PL2567690T3 PL12188047T PL12188047T PL2567690T3 PL 2567690 T3 PL2567690 T3 PL 2567690T3 PL 12188047 T PL12188047 T PL 12188047T PL 12188047 T PL12188047 T PL 12188047T PL 2567690 T3 PL2567690 T3 PL 2567690T3
Authority
PL
Poland
Prior art keywords
amisulpride
vomiting
induced nausea
treating chemotherapy
chemotherapy
Prior art date
Application number
PL12188047T
Other languages
English (en)
Inventor
Julian Clive Gilbert
Robert William Gristwood
Nicola Cooper
Gabriel Fox
Original Assignee
Acacia Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42136792&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2567690(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Acacia Pharma Ltd filed Critical Acacia Pharma Ltd
Publication of PL2567690T3 publication Critical patent/PL2567690T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0031Rectum, anus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL12188047T 2010-03-11 2011-03-10 Zastosowanie amisulprydu do leczenia pooperacyjnych nudności i wymiotów PL2567690T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1004020.2A GB201004020D0 (en) 2010-03-11 2010-03-11 New therapeutic use
EP12188047.0A EP2567690B1 (en) 2010-03-11 2011-03-10 Use of amisulpride for treating chemotherapy-induced nausea and vomiting
EP11709793.1A EP2544657B1 (en) 2010-03-11 2011-03-10 Use of amisulpride for treating post-operative nausea and vomiting

Publications (1)

Publication Number Publication Date
PL2567690T3 true PL2567690T3 (pl) 2014-11-28

Family

ID=42136792

Family Applications (3)

Application Number Title Priority Date Filing Date
PL11709793T PL2544657T3 (pl) 2010-03-11 2011-03-10 Zastosowanie amisulprydu do leczenia pooperacyjnych nudności i wymiotów
PL14173186T PL2796171T3 (pl) 2010-03-11 2011-03-10 Zastosowania amisulprydu w leczeniu nudności i wymiotów wywołanych przez opiat
PL12188047T PL2567690T3 (pl) 2010-03-11 2011-03-10 Zastosowanie amisulprydu do leczenia pooperacyjnych nudności i wymiotów

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL11709793T PL2544657T3 (pl) 2010-03-11 2011-03-10 Zastosowanie amisulprydu do leczenia pooperacyjnych nudności i wymiotów
PL14173186T PL2796171T3 (pl) 2010-03-11 2011-03-10 Zastosowania amisulprydu w leczeniu nudności i wymiotów wywołanych przez opiat

Country Status (27)

Country Link
US (11) US8686019B2 (pl)
EP (3) EP2544657B1 (pl)
JP (2) JP5886213B2 (pl)
KR (1) KR101738201B1 (pl)
CN (1) CN102892407B (pl)
AU (1) AU2011225898B2 (pl)
BR (1) BR112012022746B1 (pl)
CA (1) CA2792392C (pl)
CY (3) CY1115487T1 (pl)
DK (3) DK2796171T3 (pl)
EA (1) EA030335B1 (pl)
ES (3) ES2665418T3 (pl)
GB (1) GB201004020D0 (pl)
HK (1) HK1179152A1 (pl)
HR (3) HRP20140744T1 (pl)
HU (1) HUE037088T2 (pl)
IL (1) IL221746A (pl)
LT (1) LT2796171T (pl)
MX (3) MX370629B (pl)
NO (1) NO2796171T3 (pl)
NZ (1) NZ602279A (pl)
PL (3) PL2544657T3 (pl)
PT (3) PT2796171T (pl)
RS (3) RS57032B1 (pl)
SI (3) SI2796171T1 (pl)
SM (2) SMT201400126B (pl)
WO (1) WO2011110854A2 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201004020D0 (en) * 2010-03-11 2010-04-21 Acacia Pharma Ltd New therapeutic use
CN104435861A (zh) * 2014-12-22 2015-03-25 济南伟传信息技术有限公司 一种治疗妊娠剧吐的茶
GB201506116D0 (en) 2015-04-10 2015-05-27 Acacia Pharma Ltd Kit and combination therapy for nausea and vomiting
JP2018530744A (ja) 2015-09-02 2018-10-18 カリフォルニア インスティチュート オブ テクノロジー 低濃度の硫化水素ガスの分光学的検出のための方法および装置
GB201618425D0 (en) * 2016-11-01 2016-12-14 Acacia Pharma Ltd method
GB201702250D0 (en) * 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
WO2019113084A1 (en) 2017-12-05 2019-06-13 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
SG11202005016SA (en) 2017-12-05 2020-06-29 Sunovion Pharmaceuticals Inc Nonracemic mixtures and uses thereof
KR20220018004A (ko) 2019-06-04 2022-02-14 선오비온 파마슈티컬스 인코포레이티드 조절 방출 제형 및 이의 용도
JP2022535894A (ja) * 2019-06-04 2022-08-10 サノビオン ファーマシューティカルズ インク 放出調節製剤およびその使用
JP2023538216A (ja) * 2020-07-06 2023-09-07 アカシア ファーマ リミテッド 術後悪心嘔吐の療法
WO2023179542A1 (en) 2022-03-21 2023-09-28 Gasherbrum Bio , Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2024125602A1 (en) 2022-12-15 2024-06-20 Gasherbrum Bio, Inc. Salts and solid forms of a compound having glp-1 agonist activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2415099A1 (fr) * 1978-01-20 1979-08-17 Ile De France Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes
US6169094B1 (en) * 1998-07-14 2001-01-02 Sanofi-Synthelabo Compositions of (S) (-)-amisulpride
DE10163421A1 (de) * 2001-12-21 2003-07-31 Gruenenthal Gmbh Verwendung von (+)-(1S,2S)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)phenol als Antiemetikum
DE102005013726A1 (de) * 2005-03-22 2006-09-28 Grünenthal GmbH Transdermale therapeutische Systeme mit verbesserter Verträglichkeit
GB0506800D0 (en) * 2005-04-04 2005-05-11 Merck Sharp & Dohme New uses
US8551986B2 (en) * 2005-12-08 2013-10-08 The Mclean Hospital Corporation Treatment of sequelae of psychiatric disorders
KR101413613B1 (ko) 2006-01-27 2014-07-10 앱탈리스 파마테크, 인코포레이티드 약 염기성 선택성 세로토닌 5-ht3 차단제와 유기산을 포함하는 약물 전달 시스템
WO2007096489A1 (fr) * 2006-02-17 2007-08-30 Trimaran Limited Nouvelles compositions pharmaceutiques destinees a optimiser des traitements de substitution et elargir la pharmacopee au traitement global des addictions
US7825156B2 (en) * 2007-02-02 2010-11-02 Copharms Method of treating bipolar depression with a benzamide derivative
EP2240022B1 (en) * 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Bilayered tablets comprising oxycodone and promethazine
WO2009126931A2 (en) * 2008-04-11 2009-10-15 Xvasive, Inc. Combination therapy for bipolar disorder
GB201004020D0 (en) 2010-03-11 2010-04-21 Acacia Pharma Ltd New therapeutic use

Also Published As

Publication number Publication date
HRP20140745T1 (hr) 2014-09-26
ES2665418T3 (es) 2018-04-25
CA2792392C (en) 2018-06-19
US20210228543A1 (en) 2021-07-29
HRP20140744T1 (hr) 2014-09-26
PT2796171T (pt) 2018-04-24
DK2796171T3 (en) 2018-05-07
AU2011225898B2 (en) 2014-07-03
MX2012010411A (es) 2012-11-30
CY1115485T1 (el) 2017-01-04
US9119836B2 (en) 2015-09-01
PT2567690E (pt) 2014-09-03
CN102892407B (zh) 2016-03-23
CY1115487T1 (el) 2017-01-04
EP2544657A2 (en) 2013-01-16
SI2544657T1 (sl) 2014-12-31
RS53467B (en) 2014-12-31
PL2544657T3 (pl) 2014-10-31
MX370629B (es) 2019-12-18
US8686019B2 (en) 2014-04-01
US20200093792A1 (en) 2020-03-26
EA030335B1 (ru) 2018-07-31
MX2019015396A (es) 2020-02-07
BR112012022746A2 (pt) 2016-07-05
EP2567690A1 (en) 2013-03-13
US20130022688A1 (en) 2013-01-24
SI2567690T1 (sl) 2014-12-31
DK2544657T3 (da) 2014-08-11
HUE037088T2 (hu) 2018-08-28
US9084765B2 (en) 2015-07-21
CA2792392A1 (en) 2011-09-15
EP2796171B1 (en) 2018-01-31
US10085970B2 (en) 2018-10-02
SMT201400126B (it) 2015-05-05
CN102892407A (zh) 2013-01-23
US20180353473A1 (en) 2018-12-13
RS53466B (en) 2014-12-31
KR20130045241A (ko) 2013-05-03
BR112012022746B1 (pt) 2021-09-28
SMT201400127B (it) 2015-05-05
NZ602279A (en) 2014-08-29
HRP20180436T1 (hr) 2018-05-04
JP2016028090A (ja) 2016-02-25
PT2544657E (pt) 2014-09-03
US20220296570A1 (en) 2022-09-22
US20230144973A1 (en) 2023-05-11
US20170087128A1 (en) 2017-03-30
ES2496092T3 (es) 2014-09-18
JP5886213B2 (ja) 2016-03-16
KR101738201B1 (ko) 2017-05-19
US10525033B2 (en) 2020-01-07
RS57032B1 (sr) 2018-05-31
DK2567690T3 (da) 2014-08-11
EP2796171A1 (en) 2014-10-29
EP2544657B1 (en) 2014-07-16
CY1120170T1 (el) 2018-12-12
LT2796171T (lt) 2018-05-10
PL2796171T3 (pl) 2018-07-31
WO2011110854A3 (en) 2011-11-10
JP6279526B2 (ja) 2018-02-14
AU2011225898A1 (en) 2012-10-04
IL221746A (en) 2017-03-30
WO2011110854A2 (en) 2011-09-15
US20150335616A1 (en) 2015-11-26
NO2796171T3 (pl) 2018-06-30
US9889118B2 (en) 2018-02-13
EA201290833A1 (ru) 2013-09-30
US9545426B2 (en) 2017-01-17
US20140147517A1 (en) 2014-05-29
HK1179152A1 (zh) 2013-09-27
US20180042896A1 (en) 2018-02-15
GB201004020D0 (en) 2010-04-21
JP2013522181A (ja) 2013-06-13
ES2496099T3 (es) 2014-09-18
US20130022689A1 (en) 2013-01-24
EP2567690B1 (en) 2014-07-16
SI2796171T1 (en) 2018-05-31

Similar Documents

Publication Publication Date Title
SI2567690T1 (sl) Uporaba amisulprida za zdravljenje s kemoterapijo povzroäśenih slabosti in bruhanja
GB2513167B (en) Tetrahydrocannabivarin for use in the treatment of nausea and vomiting
HK1189587A1 (en) Bromodomain inhibitors and uses thereof
EP2651407A4 (en) 3-METHANESULFONYLPROPIONITRILE FOR THE TREATMENT OF INFLAMMATION AND PAIN
EP2603250A4 (en) Wound treatment and containment arrangement
ZA201303605B (en) Compounds and methods for treating pain
EP2533772A4 (en) METHOD AND COMPOSITIONS FOR WOUND HEALING
EP2523630A4 (en) SYSTEMS AND METHODS FOR BARIATRIC THERAPY
EP2563268A4 (en) ULTRASONIC PROCEDURE AND DEVICES FOR DENTAL TREATMENT
EP2658478A4 (en) Improved surgical implant devices and methods for their manufacture and use
ZA201208948B (en) Modified beta-lactamases and methods and uses related thereto
SG2014006068A (en) Isotopically-enriched boron-containing compounds, and methods of making and using same
GB201012336D0 (en) Surgical device and procedure
EP2574172A4 (en) MATERIALS AND METHOD FOR TREATING INFLAMMATION
EP2603176A4 (en) C1-C2 IMPLANT AND METHODS OF USE
ZA201300036B (en) Banzamide derivatives and their use as hsp90 inhibitors
IL222479A0 (en) Devices and methods for tissue engineering
EP2566483A4 (en) METHOD AND MEANS FOR IMPROVED WOUND HEALING
IL212760A0 (en) Internal and external disc shunts alleviate back pain
GB201011411D0 (en) Therapeutic compounds and their use
GB201016486D0 (en) Compounds for the use in treatment of plants
EP2654793A4 (en) METHODS AND COMPOSITIONS FOR THE TREATMENT OF LESIONS
TWM385209U (en) Device for containing and shaping growing pineapple