KR101726886B1 - 리보플라빈의 개선된 생산 - Google Patents

리보플라빈의 개선된 생산 Download PDF

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KR101726886B1
KR101726886B1 KR1020117012802A KR20117012802A KR101726886B1 KR 101726886 B1 KR101726886 B1 KR 101726886B1 KR 1020117012802 A KR1020117012802 A KR 1020117012802A KR 20117012802 A KR20117012802 A KR 20117012802A KR 101726886 B1 KR101726886 B1 KR 101726886B1
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riboflavin
rib
dna
modified
polynucleotide
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KR20110093847A (ko
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마틴 레흐만
마이클 한스
한스-피터 호흐만
디에트마르 라우데르트
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디에스엠 아이피 어셋츠 비.브이.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020117012802A 2008-11-07 2009-11-09 리보플라빈의 개선된 생산 Active KR101726886B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08019492A EP2186880A1 (en) 2008-11-07 2008-11-07 Improved production of riboflavin
EP08019492.1 2008-11-07
PCT/EP2009/064825 WO2010052319A1 (en) 2008-11-07 2009-11-09 Improved production of riboflavin

Publications (2)

Publication Number Publication Date
KR20110093847A KR20110093847A (ko) 2011-08-18
KR101726886B1 true KR101726886B1 (ko) 2017-04-13

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ID=40329198

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KR1020117012802A Active KR101726886B1 (ko) 2008-11-07 2009-11-09 리보플라빈의 개선된 생산

Country Status (7)

Country Link
US (1) US10633684B2 (https=)
EP (2) EP2186880A1 (https=)
JP (1) JP5787089B2 (https=)
KR (1) KR101726886B1 (https=)
CN (2) CN102209780B (https=)
ES (1) ES2648045T3 (https=)
WO (1) WO2010052319A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101335853B1 (ko) * 2011-12-01 2013-12-02 씨제이제일제당 (주) Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법
US10287592B2 (en) * 2014-02-07 2019-05-14 Dsm Ip Assets B.V. Bacillus host
CN103865944B (zh) * 2014-02-20 2016-01-20 天津大学 一种生产核黄素的大肠杆菌菌株及构建方法及用途
KR102561864B1 (ko) * 2014-11-19 2023-08-01 바스프 에스이 Rib７ 프로모터를 사용하여 유전자 발현을 하향조절하기 위한 에레모테시움의 유전적 변형
CN107922464B (zh) * 2015-08-28 2022-03-15 帝斯曼知识产权资产管理有限公司 经改进的维生素生产
KR101844778B1 (ko) * 2017-01-18 2018-04-04 주식회사한국야쿠르트 비타민 b2 생합성능이 매우 우수한 락토바실러스 플란타룸 hy7715 및 이를 유효성분으로 함유하는 제품
CN108330136A (zh) * 2017-05-05 2018-07-27 北京航空航天大学 一种构建产黄素单核苷酸的工程菌株的方法及其应用
WO2019055261A1 (en) * 2017-09-13 2019-03-21 Danisco Us Inc MODIFIED 5 'NON-TRANSLATED REGION (UTR) SEQUENCES FOR INCREASED PROTEIN PRODUCTION IN BACILLUS
CN111935981B (zh) 2018-04-05 2024-06-14 帝斯曼知识产权资产管理有限公司 变体麦芽糖α-淀粉酶
WO2020099303A1 (en) 2018-11-15 2020-05-22 Dsm Ip Assets B.V. Improved production of riboflavin
WO2021260057A2 (en) 2020-06-23 2021-12-30 Dsm Ip Assets B.V. Fermentation process
CN114592000B (zh) * 2020-12-03 2023-07-21 上海市农业科学院 一种六基因组合在水稻种子中提高vb2含量的应用及方法
CN112538453B (zh) * 2020-12-15 2022-07-29 通辽梅花生物科技有限公司 一种产核黄素的枯草芽孢杆菌及其构建方法与应用
CN116463305B (zh) * 2023-06-15 2023-10-17 北京易醒生物科技有限公司 一种提高用于乙醇氧化的醇氧化酶表达量的方法、优化的核黄素生物合成基因
CN117660577B (zh) * 2023-12-08 2024-06-25 苏州华赛生物工程技术有限公司 LtaSA蛋白或其编码基因在核黄素生产中的应用
CN117568433B (zh) * 2024-01-15 2024-04-16 黑龙江新和成生物科技有限公司 一种提高枯草芽孢杆菌发酵生产核黄素的方法

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CN1066486C (zh) * 1989-06-22 2001-05-30 霍夫曼-拉罗奇有限公司 高产核黄素的细菌菌株
US5837528A (en) * 1989-06-22 1998-11-17 Hoffmann La Roche, Inc. Bacterial strains which overproduce riboflavin
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6656721B1 (en) 2000-08-08 2003-12-02 Roche Vitamins, Inc. Polynucleotide portions of the biotin operon from B. subtilis for use in enhanced fermentation
JP4695068B2 (ja) 2003-06-02 2011-06-08 ディーエスエム アイピー アセッツ ビー．ブイ． 発酵によるチアミン産生
CN1809631B (zh) 2003-06-18 2010-05-26 帝斯曼知识产权资产管理有限公司 用不能形成芽孢的微生物来生产泛酸盐/酯的方法
EP1957640B1 (en) 2005-11-02 2013-05-29 DSM IP Assets B.V. Modified transketolase and use thereof

Non-Patent Citations (2)

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Title
Cell. Vol 111, 페이지 747-756, (2002)
Russian Journal of Genetics. Vol 44, No 4, 페이지 399-404 (2008)

Also Published As

Publication number Publication date
EP2186880A1 (en) 2010-05-19
US10633684B2 (en) 2020-04-28
KR20110093847A (ko) 2011-08-18
EP2356211A1 (en) 2011-08-17
JP2012507984A (ja) 2012-04-05
ES2648045T3 (es) 2017-12-28
JP5787089B2 (ja) 2015-09-30
US20110312025A1 (en) 2011-12-22
EP2356211B1 (en) 2017-09-20
CN103757000A (zh) 2014-04-30
WO2010052319A1 (en) 2010-05-14
CN102209780A (zh) 2011-10-05
CN102209780B (zh) 2016-02-10

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