KR101718372B1 - 에어로졸 볼러스로서의 일로프로스트의 투여 - Google Patents

에어로졸 볼러스로서의 일로프로스트의 투여 Download PDF

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KR101718372B1
KR101718372B1 KR1020137025804A KR20137025804A KR101718372B1 KR 101718372 B1 KR101718372 B1 KR 101718372B1 KR 1020137025804 A KR1020137025804 A KR 1020137025804A KR 20137025804 A KR20137025804 A KR 20137025804A KR 101718372 B1 KR101718372 B1 KR 101718372B1
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aerosol
composition
inhaler
inhalation
single dose
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KR20140012114A (ko
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토비아스 게슬레어
토마스 슈멜
베르네어 세에게어
로베르트 보스뷘켈
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벡투라 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020137025804A 2011-04-26 2012-04-26 에어로졸 볼러스로서의 일로프로스트의 투여 Active KR101718372B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11163659 2011-04-26
EP11163659.3 2011-04-26
PCT/EP2012/057615 WO2012146642A1 (en) 2011-04-26 2012-04-26 Administration of iloprost as aerosol bolus

Publications (2)

Publication Number Publication Date
KR20140012114A KR20140012114A (ko) 2014-01-29
KR101718372B1 true KR101718372B1 (ko) 2017-03-21

Family

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KR1020137025804A Active KR101718372B1 (ko) 2011-04-26 2012-04-26 에어로졸 볼러스로서의 일로프로스트의 투여

Country Status (19)

Country Link
US (2) US20140155486A1 (https=)
EP (2) EP2965748A1 (https=)
JP (1) JP6066350B2 (https=)
KR (1) KR101718372B1 (https=)
CN (2) CN103619323B (https=)
AU (1) AU2012247562B2 (https=)
CA (1) CA2834063C (https=)
CL (1) CL2013003057A1 (https=)
CO (1) CO6821944A2 (https=)
ES (1) ES2625282T3 (https=)
IL (1) IL228182B (https=)
NZ (1) NZ616048A (https=)
PH (1) PH12013502152B1 (https=)
PL (1) PL2701683T3 (https=)
PT (1) PT2701683T (https=)
RU (1) RU2605849C2 (https=)
TW (1) TWI602568B (https=)
WO (1) WO2012146642A1 (https=)
ZA (1) ZA201307908B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104853744B (zh) * 2012-10-31 2018-01-19 维克多瑞有限责任公司 气溶胶化伊洛前列素的给药
WO2015074663A1 (en) * 2013-11-19 2015-05-28 Rigshospitalet Injectable pharmaceutical compositions comprising iloprost
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
MA45036A (fr) 2016-05-18 2019-03-27 Modernatx Inc Polynucléotides codant pour la citrine pour le traitement de la citrullinémie de type 2
EP3968963A4 (en) 2019-05-16 2023-02-01 Aerovate Therapeutics, Inc. IMATINIB FORMULATIONS, THEIR PREPARATION AND USES
US20250000873A1 (en) 2021-09-10 2025-01-02 Justus-Liebig-Universitaet Giessen Inhaled iloprost for rescue treatment and treatment as needed in pulmonary hypertension
CN113952320B (zh) * 2021-09-18 2022-03-18 健康元药业集团股份有限公司 一种包含妥布霉素吸入溶液的药物组件及其用途
CN113712526B (zh) * 2021-09-30 2022-12-30 四川大学 一种脉搏波提取方法、装置、电子设备及存储介质
CN114652704A (zh) * 2022-04-29 2022-06-24 兆科药业（广州）有限公司 一种曲前列尼尔软雾吸入剂

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US6972869B2 (en) 2000-12-18 2005-12-06 Xerox Corporation Mapping color to colorant amounts when colorants have similar hue
MX2007000979A (es) * 2004-07-26 2007-07-11 Cotherix Inc Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada.
EP1712220A1 (en) * 2005-04-15 2006-10-18 PARI GmbH Spezialisten für effektive Inhalation Pharmaceutical aerosol composition
CN101495122B (zh) * 2006-05-15 2011-10-05 联合治疗公司 使用定量吸入器给予曲前列尼
WO2010008424A2 (en) 2008-04-04 2010-01-21 Novartis Ag Aerosolization device
US8668901B2 (en) * 2009-02-04 2014-03-11 Activaero Gmbh Research & Development Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
emc medicine guides : "SPC Ventavis " (2010-07-13).
EUR RESPI R J 17:14-19(2001).*
PHARMACEUTICAL RESEARCH 24(2); 277-287(2006.12.27.).

Also Published As

Publication number Publication date
AU2012247562B2 (en) 2015-12-17
US20140155486A1 (en) 2014-06-05
TW201249442A (en) 2012-12-16
EP2965748A1 (en) 2016-01-13
KR20140012114A (ko) 2014-01-29
US20170014424A1 (en) 2017-01-19
IL228182B (en) 2018-07-31
CN106420676B (zh) 2020-04-28
CN106420676A (zh) 2017-02-22
CL2013003057A1 (es) 2014-08-01
RU2013151018A (ru) 2015-06-27
CO6821944A2 (es) 2013-12-31
CA2834063A1 (en) 2012-11-01
AU2012247562A1 (en) 2013-09-26
JP2014513091A (ja) 2014-05-29
PT2701683T (pt) 2017-05-03
WO2012146642A1 (en) 2012-11-01
RU2605849C2 (ru) 2016-12-27
PL2701683T3 (pl) 2017-08-31
CN103619323B (zh) 2016-08-17
CA2834063C (en) 2016-01-05
US10821116B2 (en) 2020-11-03
TWI602568B (zh) 2017-10-21
ES2625282T3 (es) 2017-07-19
NZ616048A (en) 2015-07-31
CN103619323A (zh) 2014-03-05
EP2701683B1 (en) 2017-03-08
HK1190627A1 (zh) 2014-07-11
PH12013502152B1 (en) 2018-12-14
ZA201307908B (en) 2014-07-30
PH12013502152A1 (en) 2014-01-13
JP6066350B2 (ja) 2017-01-25
EP2701683A1 (en) 2014-03-05

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