KR101699095B1 - ２-아실아미노-３-디페닐프로판산의 제조 및 분할 방법 - Google Patents
２-아실아미노-３-디페닐프로판산의 제조 및 분할 방법 Download PDFInfo
- Publication number
- KR101699095B1 KR101699095B1 KR1020117018824A KR20117018824A KR101699095B1 KR 101699095 B1 KR101699095 B1 KR 101699095B1 KR 1020117018824 A KR1020117018824 A KR 1020117018824A KR 20117018824 A KR20117018824 A KR 20117018824A KR 101699095 B1 KR101699095 B1 KR 101699095B1
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- acid
- compound
- alkyl
- rti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(N[C@@](Cc(cc1)ccc1-c1ccccc1)C(O)=O)=O Chemical compound *C(N[C@@](Cc(cc1)ccc1-c1ccccc1)C(O)=O)=O 0.000 description 3
- HDNGVBPPMAZUMI-UHFFFAOYSA-N CC(NC(Cc(cc1)ccc1-c1ccccc1)C(O)=O)=O Chemical compound CC(NC(Cc(cc1)ccc1-c1ccccc1)C(O)=O)=O HDNGVBPPMAZUMI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910045210A CN101774941A (zh) | 2009-01-13 | 2009-01-13 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
| CN200910045210.1 | 2009-01-13 | ||
| PCT/CN2010/070144 WO2010081410A1 (en) | 2009-01-13 | 2010-01-12 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110116167A KR20110116167A (ko) | 2011-10-25 |
| KR101699095B1 true KR101699095B1 (ko) | 2017-01-23 |
Family
ID=42339450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117018824A Expired - Fee Related KR101699095B1 (ko) | 2009-01-13 | 2010-01-12 | ２-아실아미노-３-디페닐프로판산의 제조 및 분할 방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8703990B2 (enExample) |
| EP (1) | EP2387558B1 (enExample) |
| JP (1) | JP5687205B2 (enExample) |
| KR (1) | KR101699095B1 (enExample) |
| CN (4) | CN101774941A (enExample) |
| AU (1) | AU2010205973B2 (enExample) |
| BR (1) | BRPI1007367A2 (enExample) |
| CA (1) | CA2749092C (enExample) |
| ES (1) | ES2524971T3 (enExample) |
| HR (1) | HRP20141148T1 (enExample) |
| MX (1) | MX2011007445A (enExample) |
| PL (1) | PL2387558T3 (enExample) |
| PT (1) | PT2387558E (enExample) |
| RU (1) | RU2520215C2 (enExample) |
| SI (1) | SI2387558T1 (enExample) |
| WO (1) | WO2010081410A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101684077B (zh) | 2008-09-24 | 2013-01-02 | 浙江九洲药业股份有限公司 | N-酰基联苯丙氨酸的制备方法 |
| CN101774941A (zh) * | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
| EP2480523B1 (en) * | 2009-09-23 | 2017-03-01 | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. | Process for manufacture of n-acylbphenyl alanine |
| JP6150179B2 (ja) * | 2011-08-19 | 2017-06-21 | パセオン オーストリア ゲーエムベーハー ウント ツェーオー カーゲー | Ｒ−ビフェニルアラニノールの合成 |
| CN102952029B (zh) * | 2011-09-30 | 2015-07-08 | 北京海步国际医药科技发展有限公司 | 将苄胺衍生物用于拆分2-羟基-3-甲氧基-3,3-二-苯基丙酸消旋物及拆分方法 |
| CN105085321B (zh) * | 2012-03-07 | 2017-11-24 | 浙江九洲药业股份有限公司 | 一种n‑甲氧羰基‑l‑叔亮氨酸的制备方法 |
| WO2016037098A1 (en) | 2014-09-04 | 2016-03-10 | Concert Pharmaceuticals, Inc. | Deuterated sacubitril |
| TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
| CN105017082B (zh) * | 2015-07-31 | 2017-09-19 | 上海皓元医药股份有限公司 | 一种心衰药Entresto 关键中间体(R)‑叔丁基 (1‑([1,1`‑联苯]‑4‑基)‑3‑羟基丙烷‑2‑基)氨基甲酸酯的制备方法 |
| CN105085322B (zh) * | 2015-08-15 | 2017-10-03 | 浙江永宁药业股份有限公司 | Ahu‑377中间体的制备方法及其中间体和中间体的制备方法 |
| CN105168205A (zh) * | 2015-08-18 | 2015-12-23 | 泰力特医药（湖北）有限公司 | 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法 |
| WO2017051326A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | New processes and intermediates useful in synthesis of nep inhibitors |
| CN105198775B (zh) | 2015-10-10 | 2017-11-14 | 凯瑞斯德生化(苏州)有限公司 | 一种手性N‑Boc联苯丙氨醇的制备方法 |
| EP3386955B1 (en) | 2015-12-10 | 2020-08-05 | Novartis AG | Intermediates for the preparation of sacubitril and their preparation |
| KR20170119447A (ko) * | 2016-04-19 | 2017-10-27 | 주식회사 아미노로직스 | Dl-4,4'-바이페닐알라닌 알킬에스터로부터 d-4,4'-바이페닐알라닌 알킬에스터 또는 l-4,4'-바이페닐알라닌 알킬에스터를 제조하는 방법 |
| EP3481799A1 (en) | 2016-07-05 | 2019-05-15 | Novartis AG | New process for early sacubitril intermediates |
| JP6945619B2 (ja) | 2016-08-17 | 2021-10-06 | ノバルティス アーゲー | Ｎｅｐ阻害剤合成のための新規な方法および中間体 |
| WO2018116203A1 (en) | 2016-12-23 | 2018-06-28 | Novartis Ag | New process for early sacubitril intermediates |
| JP6843696B2 (ja) * | 2017-04-28 | 2021-03-17 | キヤノン株式会社 | 電源装置及び画像形成装置 |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
| CN110183357B (zh) * | 2019-06-13 | 2021-09-24 | 甘肃皓天医药科技有限责任公司 | 一种用于制备沙库比曲中间体的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1623980A (zh) * | 2003-12-04 | 2005-06-08 | 上海药明康德新药开发有限公司 | 一种光学纯N－叔丁基氧羰基－β－二氟苯丙氨酸的制备方法 |
| JP2007063267A (ja) * | 2005-08-04 | 2007-03-15 | Ajinomoto Co Inc | 光学活性なジフェニルアラニン化合物の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61227555A (ja) | 1985-04-02 | 1986-10-09 | Mitsui Toatsu Chem Inc | Ｎ−アシルフエニルアラニン類の製造方法 |
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| FR2833949B1 (fr) * | 2001-12-21 | 2005-08-05 | Galderma Res & Dev | NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE |
| ES2290429T3 (es) | 2002-01-17 | 2008-02-16 | Novartis Ag | Composiciones farmaceuticas que comprenden valsartan e inhibidores de nep. |
| JP4270484B2 (ja) * | 2002-03-08 | 2009-06-03 | 第一ファインケミカル株式会社 | 光学活性フェニルアラニン誘導体の製造方法 |
| GB0329584D0 (en) * | 2003-12-20 | 2004-01-28 | Tanabe Seiyaku Co | Novel compounds |
| EP1749816A1 (en) | 2005-08-04 | 2007-02-07 | Ajinomoto Co., Ltd. | Production method of optically active diphenylalanine compounds |
| CN101774941A (zh) * | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
-
2009
- 2009-01-13 CN CN200910045210A patent/CN101774941A/zh active Pending
-
2010
- 2010-01-12 BR BRPI1007367A patent/BRPI1007367A2/pt not_active IP Right Cessation
- 2010-01-12 SI SI201030791T patent/SI2387558T1/sl unknown
- 2010-01-12 CN CN201110425581XA patent/CN102531944A/zh active Pending
- 2010-01-12 US US13/144,340 patent/US8703990B2/en active Active
- 2010-01-12 EP EP10731044.3A patent/EP2387558B1/en active Active
- 2010-01-12 PL PL10731044T patent/PL2387558T3/pl unknown
- 2010-01-12 WO PCT/CN2010/070144 patent/WO2010081410A1/en not_active Ceased
- 2010-01-12 MX MX2011007445A patent/MX2011007445A/es active IP Right Grant
- 2010-01-12 RU RU2011133749/04A patent/RU2520215C2/ru not_active IP Right Cessation
- 2010-01-12 AU AU2010205973A patent/AU2010205973B2/en not_active Ceased
- 2010-01-12 ES ES10731044.3T patent/ES2524971T3/es active Active
- 2010-01-12 PT PT107310443T patent/PT2387558E/pt unknown
- 2010-01-12 CN CN201080004463.5A patent/CN102482202B/zh active Active
- 2010-01-12 JP JP2011544780A patent/JP5687205B2/ja active Active
- 2010-01-12 CN CN201410753416.0A patent/CN104557599B/zh active Active
- 2010-01-12 HR HRP20141148AT patent/HRP20141148T1/hr unknown
- 2010-01-12 CA CA2749092A patent/CA2749092C/en not_active Expired - Fee Related
- 2010-01-12 KR KR1020117018824A patent/KR101699095B1/ko not_active Expired - Fee Related
-
2014
- 2014-02-28 US US14/193,503 patent/US9181175B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1623980A (zh) * | 2003-12-04 | 2005-06-08 | 上海药明康德新药开发有限公司 | 一种光学纯N－叔丁基氧羰基－β－二氟苯丙氨酸的制备方法 |
| JP2007063267A (ja) * | 2005-08-04 | 2007-03-15 | Ajinomoto Co Inc | 光学活性なジフェニルアラニン化合物の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102482202B (zh) | 2015-02-18 |
| US20140179947A1 (en) | 2014-06-26 |
| EP2387558B1 (en) | 2014-08-27 |
| WO2010081410A1 (en) | 2010-07-22 |
| AU2010205973A1 (en) | 2011-08-04 |
| EP2387558A4 (en) | 2012-08-08 |
| SI2387558T1 (sl) | 2014-12-31 |
| US9181175B2 (en) | 2015-11-10 |
| CN101774941A (zh) | 2010-07-14 |
| CN104557599B (zh) | 2017-02-22 |
| CN102531944A (zh) | 2012-07-04 |
| CA2749092A1 (en) | 2010-07-22 |
| KR20110116167A (ko) | 2011-10-25 |
| US20120016151A1 (en) | 2012-01-19 |
| BRPI1007367A2 (pt) | 2019-09-24 |
| PT2387558E (pt) | 2014-11-14 |
| EP2387558A1 (en) | 2011-11-23 |
| JP2012515142A (ja) | 2012-07-05 |
| HRP20141148T1 (hr) | 2015-01-30 |
| US8703990B2 (en) | 2014-04-22 |
| JP5687205B2 (ja) | 2015-03-18 |
| MX2011007445A (es) | 2011-10-28 |
| ES2524971T3 (es) | 2014-12-16 |
| CN104557599A (zh) | 2015-04-29 |
| RU2011133749A (ru) | 2013-02-20 |
| AU2010205973B2 (en) | 2013-02-07 |
| CN102482202A (zh) | 2012-05-30 |
| CA2749092C (en) | 2017-01-10 |
| PL2387558T3 (pl) | 2015-03-31 |
| RU2520215C2 (ru) | 2014-06-20 |
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