KR101692707B1 - 가용성 구아닐레이트 사이클라제 활성제로서의 알콕시 피라졸 - Google Patents

가용성 구아닐레이트 사이클라제 활성제로서의 알콕시 피라졸 Download PDF

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KR101692707B1
KR101692707B1 KR1020157005961A KR20157005961A KR101692707B1 KR 101692707 B1 KR101692707 B1 KR 101692707B1 KR 1020157005961 A KR1020157005961 A KR 1020157005961A KR 20157005961 A KR20157005961 A KR 20157005961A KR 101692707 B1 KR101692707 B1 KR 101692707B1
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compound
electrospray
mmol
alkyl
mixture
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KR20150048765A (ko
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제로드 버넷 브렌너먼
존 데이비드 진
마이클 디. 로우
크리스토퍼 로날드 사르코
에드워드 에스. 타스버
중화 장
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베링거 인겔하임 인터내셔날 게엠베하
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
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KR1020157005961A 2012-09-07 2013-09-03 가용성 구아닐레이트 사이클라제 활성제로서의 알콕시 피라졸 Active KR101692707B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261697899P 2012-09-07 2012-09-07
US61/697,899 2012-09-07
PCT/US2013/057826 WO2014039434A1 (en) 2012-09-07 2013-09-03 Alkoxy pyrazoles as soluble guanylate cyclase activators

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KR20150048765A KR20150048765A (ko) 2015-05-07
KR101692707B1 true KR101692707B1 (ko) 2017-01-04

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US (2) US8906904B2 (https=)
EP (1) EP2892891B1 (https=)
JP (1) JP5970134B2 (https=)
KR (1) KR101692707B1 (https=)
CN (1) CN104619695B (https=)
AP (1) AP2015008231A0 (https=)
AR (1) AR092869A1 (https=)
AU (1) AU2013312931B2 (https=)
BR (1) BR112015004529B1 (https=)
CA (1) CA2880494C (https=)
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EA (1) EA027244B1 (https=)
EC (1) ECSP15012804A (https=)
ES (1) ES2748798T3 (https=)
GE (1) GEP20176631B (https=)
HR (1) HRP20191755T1 (https=)
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TW201625584A (zh) 2014-07-02 2016-07-16 諾華公司 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
EP3172202B1 (en) * 2014-07-22 2020-01-29 Boehringer Ingelheim International GmbH Heterocyclic carboxylic acids as activators of soluble guanylate cyclase
JP2018537488A (ja) 2015-12-18 2018-12-20 ノバルティス アーゲー インダン誘導体、ならびに可溶性グアニル酸シクラーゼ活性化剤としてのその使用
CA3039735A1 (en) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Combination containing sgc activators and mineralocorticoid receptor antagonists
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
JP7314173B2 (ja) 2018-04-30 2023-07-25 バイエル アクチェンゲゼルシャフト 認知障害の治療のためのｓＧＣ活性化薬及びｓＧＣ刺激薬の使用
CA3100096A1 (en) 2018-05-15 2019-11-21 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
EP3574905A1 (en) 2018-05-30 2019-12-04 Adverio Pharma GmbH Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group
EP3820470B1 (en) 2018-07-12 2024-09-11 Boehringer Ingelheim International GmbH Alkoxy pyrazoles as soluble guanylate cyclase activators for use in treating portal hypertension
EP3911675A1 (en) 2019-01-17 2021-11-24 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
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CN112079712B (zh) * 2020-09-18 2022-12-13 江苏美迪克化学品有限公司 一种对乙烯基水杨酸的制备方法
EP4259617B1 (en) * 2020-12-10 2024-10-23 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
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GB202102895D0 (en) 2021-03-01 2021-04-14 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof
CN118900690A (zh) 2022-03-21 2024-11-05 勃林格殷格翰国际有限公司 用于治疗门脉高压的可溶性鸟苷酸环化酶活化剂
EP4536205A1 (en) 2022-06-09 2025-04-16 Bayer Aktiengesellschaft Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women
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