KR101688547B1 - 아포리포단백질 ａ-ｉ 모방체 - Google Patents

아포리포단백질 ａ-ｉ 모방체 Download PDF

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KR101688547B1
KR101688547B1 KR1020117021736A KR20117021736A KR101688547B1 KR 101688547 B1 KR101688547 B1 KR 101688547B1 KR 1020117021736 A KR1020117021736 A KR 1020117021736A KR 20117021736 A KR20117021736 A KR 20117021736A KR 101688547 B1 KR101688547 B1 KR 101688547B1
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leu
amino acid
peptide
acid residue
lipid
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KR20120004412A (ko
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장 루이 다쓰
애나 쉔드로바 쉔드맨
링위 주
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세레니스 쎄라퓨틱스 홀딩 에스에이
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
KR1020117021736A 2009-02-16 2010-02-12 아포리포단백질 ａ-ｉ 모방체 Expired - Fee Related KR101688547B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US15296609P 2009-02-16 2009-02-16
US15296209P 2009-02-16 2009-02-16
US15296009P 2009-02-16 2009-02-16
US61/152,960 2009-02-16
US61/152,962 2009-02-16
US61/152,966 2009-02-16
PCT/US2010/024096 WO2010093918A1 (en) 2009-02-16 2010-02-12 Apolipoprotein a-i mimics

Publications (2)

Publication Number Publication Date
KR20120004412A KR20120004412A (ko) 2012-01-12
KR101688547B1 true KR101688547B1 (ko) 2016-12-21

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US (4) US8378068B2 (enExample)
EP (2) EP2396017B1 (enExample)
JP (2) JP5719783B2 (enExample)
KR (1) KR101688547B1 (enExample)
CN (2) CN102395375B (enExample)
AU (1) AU2010213568B2 (enExample)
CA (2) CA2982157A1 (enExample)
CY (1) CY1118809T1 (enExample)
DK (2) DK2939683T3 (enExample)
ES (2) ES2620478T3 (enExample)
HK (1) HK1209436A1 (enExample)
HR (2) HRP20150998T1 (enExample)
HU (2) HUE033661T2 (enExample)
IL (2) IL214576B (enExample)
LT (1) LT2939683T (enExample)
MX (3) MX386110B (enExample)
NZ (1) NZ594516A (enExample)
PH (1) PH12016501912A1 (enExample)
PL (2) PL2939683T3 (enExample)
PT (2) PT2939683T (enExample)
RU (2) RU2532222C2 (enExample)
SG (1) SG173624A1 (enExample)
SI (2) SI2939683T1 (enExample)
SM (2) SMT201700203T1 (enExample)
WO (1) WO2010093918A1 (enExample)
ZA (1) ZA201105997B (enExample)

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US10151037B2 (en) 2009-01-12 2018-12-11 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide dependent target reduction, and related methods and systems
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US12226529B2 (en) 2015-08-25 2025-02-18 Lawrence Livermore National Security, Llc Stable nanolipoprotein particles and related compositions methods and systems
WO2017044899A1 (en) * 2015-09-11 2017-03-16 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
US20190201540A1 (en) * 2016-05-24 2019-07-04 Stc Unm Immunogens, compositions, and methods for treating dyslipidemia
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CN116322646A (zh) 2020-10-01 2023-06-23 阿比奥尼克斯制药公司 用于治疗眼病的包含基于脂质结合蛋白的复合物的组合物
WO2022125878A1 (en) * 2020-12-11 2022-06-16 The Regents Of The University Of Michigan Compositions and methods for preventing, attenuating, and treating medical conditions with shdl nanoparticles
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CN114940711B (zh) * 2021-10-25 2023-05-12 中山大学 载脂蛋白a-i模拟肽及其应用
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PL2939683T3 (pl) 2017-07-31
SMT201500318B (it) 2016-02-25
SI2396017T1 (sl) 2015-12-31
NZ594516A (en) 2012-12-21
CN102395375B (zh) 2015-01-14
US9981008B2 (en) 2018-05-29
EP2396017A4 (en) 2013-03-27
IL240357A0 (en) 2015-09-24
HK1165987A1 (en) 2012-10-19
IL214576B (en) 2019-05-30
ES2620478T3 (es) 2017-06-28
AU2010213568B2 (en) 2014-11-20
EP2396017A1 (en) 2011-12-21
CN104530223A (zh) 2015-04-22
HK1209436A1 (en) 2016-04-01
US9388232B2 (en) 2016-07-12
RU2532222C2 (ru) 2014-10-27
HUE026062T2 (en) 2016-05-30
IL214576A0 (en) 2011-09-27
JP2015110677A (ja) 2015-06-18
MX2011008599A (es) 2011-11-18
EP2939683A1 (en) 2015-11-04
WO2010093918A1 (en) 2010-08-19
CN102395375A (zh) 2012-03-28
US20150141330A1 (en) 2015-05-21
RU2014134333A (ru) 2016-03-20
LT2939683T (lt) 2017-03-27
SG173624A1 (en) 2011-09-29
US8378068B2 (en) 2013-02-19
CA2982157A1 (en) 2010-08-19
SI2939683T1 (sl) 2017-04-26
ZA201105997B (en) 2013-10-30
ES2554853T3 (es) 2015-12-23
US8993597B2 (en) 2015-03-31
HUE033661T2 (en) 2017-12-28
PT2939683T (pt) 2017-04-07
HRP20150998T1 (hr) 2015-11-20
SMT201700203T1 (it) 2017-05-08
CA2752182A1 (en) 2010-08-19
US20160324923A1 (en) 2016-11-10
HRP20170294T1 (hr) 2017-04-21
RU2011138011A (ru) 2013-03-27
JP2012518006A (ja) 2012-08-09
IL240357A (en) 2017-11-30
EP2939683B1 (en) 2017-01-04
US20130231459A1 (en) 2013-09-05
PT2396017E (pt) 2015-10-22
PL2396017T3 (pl) 2015-12-31
KR20120004412A (ko) 2012-01-12
JP5719783B2 (ja) 2015-05-20
MX343654B (es) 2016-11-16
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