KR101685712B1 - 맞춤형 멀티사이트 조합 어셈블리 - Google Patents

맞춤형 멀티사이트 조합 어셈블리 Download PDF

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KR101685712B1
KR101685712B1 KR1020107003986A KR20107003986A KR101685712B1 KR 101685712 B1 KR101685712 B1 KR 101685712B1 KR 1020107003986 A KR1020107003986 A KR 1020107003986A KR 20107003986 A KR20107003986 A KR 20107003986A KR 101685712 B1 KR101685712 B1 KR 101685712B1
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primers
primer
polynucleotide
template
mutations
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KR20100045494A (ko
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주퀴우 탄
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비피 코포레이션 노쓰 아메리카 인코포레이티드
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Application filed by 비피 코포레이션 노쓰 아메리카 인코포레이티드 filed Critical 비피 코포레이션 노쓰 아메리카 인코포레이티드
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Assigned to 바스프 엔자임스 엘엘씨 reassignment 바스프 엔자임스 엘엘씨 권리의 전부이전등록 Assignors: 비피 코포레이션 노쓰 아메리카 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020107003986A 2007-07-31 2008-07-31 맞춤형 멀티사이트 조합 어셈블리 Expired - Fee Related KR101685712B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95317107P 2007-07-31 2007-07-31
US60/953,171 2007-07-31
PCT/US2008/071771 WO2009018449A1 (en) 2007-07-31 2008-07-31 Tailored multi-site combinatorial assembly

Publications (2)

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KR20100045494A KR20100045494A (ko) 2010-05-03
KR101685712B1 true KR101685712B1 (ko) 2016-12-12

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Country Link
US (1) US9476078B2 (https=)
EP (2) EP3031919B1 (https=)
JP (1) JP6014805B2 (https=)
KR (1) KR101685712B1 (https=)
CN (2) CN104673784A (https=)
AU (1) AU2008282101A1 (https=)
BR (1) BRPI0815046A2 (https=)
CA (1) CA2693102C (https=)
DK (1) DK3031919T3 (https=)
EA (1) EA020657B1 (https=)
ES (1) ES2701883T3 (https=)
IL (1) IL202839A0 (https=)
MX (1) MX353478B (https=)
NZ (1) NZ582876A (https=)
WO (1) WO2009018449A1 (https=)
ZA (1) ZA201000152B (https=)

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NZ596459A (en) 2009-05-21 2013-11-29 Verenium Corp Phytases, nucleic acids encoding them and methods for making and using them
US9096871B2 (en) 2010-10-06 2015-08-04 Bp Corporation North America Inc. Variant CBH I polypeptides with reduced product inhibition
WO2014070856A2 (en) 2012-11-02 2014-05-08 Bp Corporation North America Inc. Thermotolerant beta-glucosidase variants
GB201308828D0 (en) 2013-03-12 2013-07-03 Verenium Corp Phytase
GB201308843D0 (en) 2013-03-14 2013-07-03 Verenium Corp Phytase formulation
EP3027762A4 (en) 2013-07-25 2017-06-28 BASF Enzymes LLC Phytase
WO2018183612A1 (en) * 2017-03-29 2018-10-04 Editas Medicine, Inc. Nucleic acid mutagenesis methods
MX2020004318A (es) 2017-10-25 2020-08-13 Basf Se Enzimas beta-amilasa.
EP3728620A4 (en) * 2017-12-20 2021-11-03 Basf Se GENE SITE SATURATION MUTAGENESIS (GSSM) PROCESS
EP3728574A1 (en) 2017-12-20 2020-10-28 Basf Se Nucleases and methods for making and using them
US11732250B2 (en) 2018-04-26 2023-08-22 Basf Se Lipase enzymes
CN112384616B (zh) 2018-05-29 2024-09-03 巴斯夫欧洲公司 淀粉酶
US12460221B2 (en) 2018-09-07 2025-11-04 Basf Plant Science Company Gmbh Method for the production of high levels of PUFA in plants
CA3110656A1 (en) 2018-09-07 2020-03-12 Basf Plant Science Company Gmbh Improved method for the production of high levels of pufa in plants
EP3847264A1 (en) 2018-09-07 2021-07-14 Basf Plant Science Company GmbH Improved method for the production of high levels of pufa in plants
US20220186200A1 (en) 2019-03-11 2022-06-16 Basf Se Amylases and methods for making and using them
CA3176520A1 (en) 2019-04-23 2020-10-29 Basf Se Beta-amylase variants
US20230041211A1 (en) 2019-12-20 2023-02-09 Basf Se Decreasing toxicity of terpenes and increasing the production potential in micro-organisms
BR112022024475A2 (pt) 2020-06-04 2022-12-27 Isobionics B V Beta santaleno sintase sintética, ácido nucleico sintético, cassete de expressão, método para produzir uma composição, célula hospedeira não humana, composição, e, uso de qualquer uma das santaleno sintases sintéticas
EP4015626A1 (en) 2020-12-18 2022-06-22 Isobionics B.V. Enzymes and methods for fermentative production of monoterpene esters
JP2024528957A (ja) 2021-08-02 2024-08-01 ビーエーエスエフ ソシエタス・ヨーロピア イオニリデンエタンシンターゼによる新規な芳香化合物の生成

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Publication number Publication date
EP2183378A4 (en) 2010-09-22
DK3031919T3 (en) 2019-01-07
JP2010535034A (ja) 2010-11-18
EA020657B1 (ru) 2014-12-30
BRPI0815046A2 (pt) 2014-10-14
MX2010001182A (es) 2010-04-21
EP2183378A1 (en) 2010-05-12
US9476078B2 (en) 2016-10-25
US20100216192A1 (en) 2010-08-26
EA201070206A1 (ru) 2010-06-30
CA2693102A1 (en) 2009-02-05
ZA201000152B (en) 2011-06-29
CN101821402A (zh) 2010-09-01
WO2009018449A1 (en) 2009-02-05
NZ582876A (en) 2012-07-27
ES2701883T3 (es) 2019-02-26
IL202839A0 (en) 2010-06-30
CN104673784A (zh) 2015-06-03
KR20100045494A (ko) 2010-05-03
EP3031919A1 (en) 2016-06-15
MX353478B (es) 2018-01-15
CN101821402B (zh) 2015-03-04
JP6014805B2 (ja) 2016-10-26
AU2008282101A1 (en) 2009-02-05
CA2693102C (en) 2020-03-10
EP3031919B1 (en) 2018-09-19

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