KR20210084590A - 조작된 dna 중합효소 변이체 - Google Patents

조작된 dna 중합효소 변이체 Download PDF

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KR20210084590A
KR20210084590A KR1020217016433A KR20217016433A KR20210084590A KR 20210084590 A KR20210084590 A KR 20210084590A KR 1020217016433 A KR1020217016433 A KR 1020217016433A KR 20217016433 A KR20217016433 A KR 20217016433A KR 20210084590 A KR20210084590 A KR 20210084590A
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매튜 쥐 밀러
베스나 미첼
조바나 나조르
도날드 에스 베스커빌
니키 델라스
데이비드 엘가트
조나단 브룸
샌디 엠 곰즈
난디타 수브라마니안
에리카 베르무데즈
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Abstract

본 발명은 조작된 DNA 중합효소 폴리펩티드 및 그의 조성물, 그리고 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 제공한다. 본 발명은 또한 진단 및 기타 목적을 위해 조작된 DNA 중합효소 폴리펩티드를 포함하는 조성물의 사용 방법을 제공한다.

Description

조작된 DNA 중합효소 변이체
본 출원은 2018년 10월 29일에 출원된 미국 가특허 출원 제62/752,215호를 우선권으로 주장하며, 상기 가출원은 모든 목적상 그 전체가 참고로 포함된다.
서열 목록, 표 또는 컴퓨터 프로그램에 대한 참조
파일명 CX9-181WO2_ST25.txt로서 EFS-Web을 통한 컴퓨터 판독 가능 형식(CRF: computer readable form)으로 37 C.F.R. §1.821에 따라 본원과 동시에 제출된 서열 목록은 본원에 참고로 포함된다. 서열 목록의 전자 사본은 2019년 10월 28일에 생성되었으며 파일 크기는 5,361 Kbyte이다.
발명의 분야
본 발명은 조작된 DNA 중합효소 폴리펩티드 및 그의 조성물, 그리고 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 제공한다. 본 발명은 또한 진단 및 기타 목적을 위해 조작된 DNA 중합효소 폴리펩티드를 포함하는 조성물의 사용 방법을 제공한다.
DNA 중합효소는 데옥시리보뉴클레오티드로부터 DNA를 합성하는 효소이다. 이 효소는 DNA 복제에 필수적이다. 다양한 유형의 DNA 중합효소가 존재하며, 이들은 일반적으로 7가지 계열, 즉 A, B, C, D, X, Y, 및 RT로 나뉜다. 이 계열은 상이한 특성을 가지며 상이한 유형의 유기체에서 발견된다. 예를 들어, 그룹 A 중합효소는 진핵생물과 원핵생물 모두에서 발견되는 복제 및 복구 중합효소이다(예를 들어, T7 DNA 중합효소, 및 이. 콜라이(E. coli) polI을 포함함). 그룹 B 중합효소는 또한 진핵생물과 원핵생물에서 발견되는 복제 및 복구 효소이다(예를 들어, pol II, pol B 등). 그룹 C와 D는 각각 원핵생물과 유리고세균(Euryarchaeota)에서 발견되는 복제 중합효소를 포함한다(그룹 C 중합효소에는 pol III이 포함되지만 그룹 D 중합효소는 잘 특성화되지 않음). 그룹 X, Y, 및 RT 중합효소는 진핵생물(그룹 X), 진핵생물 및 원핵생물(그룹 Y), 및 바이러스, 레트로바이러스, 및 진핵 생물(그룹 RT)에서 발견되는 복제 및 복구 효소이다. 그룹 X 중합효소의 예에는 pol β가 포함되는 반면, 그룹 Y 중합효소에는 pol IV 및 pol V가 포함되며, 그룹 RT 중합효소에는 B형 간염 바이러스의 중합효소가 포함된다. 이들 중합효소 중 일부, 특히 고온성 유기체로부터 얻은 중합효소는 중합효소 연쇄 반응(PCR: polymerase chain reaction)을 포함하지만 이에 제한되지 않는 다양한 시험관 내 방법에서 매우 많이 사용되어왔다. 고온성 중합효소의 가용성은 PCR의 자동화를 가능하게 하였다. 따라서, 이들은 PCR이 유용한 적용 분야에서 매우 중요한 효소이다. 시판되는 수많은 효소(예를 들어, Taq 및 기타 여러 가지)가 있지만, 당 업계에서는 높은 수준의 충실도(fidelity)를 가진 열안정성 효소가 여전히 요구된다.
본 발명은 조작된 DNA 중합효소 폴리펩티드 및 그의 조성물, 그리고 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 제공한다. 본 발명은 또한 진단 및 기타 목적을 위해 조작된 DNA 중합효소 폴리펩티드를 포함하는 조성물의 사용 방법을 제공한다.
본 발명은 서열번호 2, 6, 22, 24, 26, 28 및/또는 824의 참조 서열과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 서열 동일성을 갖는 폴리펩티드 서열 또는 이의 기능적 단편을 포함하는 조작된 DNA 중합효소로서, 조작된 DNA 중합효소는 폴리펩티드 서열에 적어도 하나의 치환 또는 치환 세트를 포함하며, 폴리펩티드 서열의 아미노산 위치는 서열번호 2, 6, 22, 24, 26, 28 및/또는 824를 참조하여 넘버링되는 것인 조작된 DNA 중합효소를 제공한다.
또한, 본 발명은
Figure pct00001
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00002
로부터 선택되며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다.
또한, 본 발명은
Figure pct00003
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00004
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00005
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다.
본 발명은 또한
Figure pct00006
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00007
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00008
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다.
본 발명은 또한 100, 277, 280, 281, 283, 339, 401, 468, 479, 480, 482, 489, 490, 491, 496, 497 및 498, 및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00009
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00010
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다.
본 발명은 또한
Figure pct00011
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00012
Figure pct00013
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00014
Figure pct00015
로부터 선택되며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다.
본 발명은 또한
Figure pct00016
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00017
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00018
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다.
본 발명은 또한
Figure pct00019
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 26을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00020
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 26을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00021
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 26을 참조하여 넘버링된다.
본 발명은 또한
Figure pct00022
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00023
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00024
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다.
본 발명은 또한 257, 420, 515 및 521, 및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 257W, 420Q, 515L, 및 521S, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 M257W, R420Q, K515L, 및 K521S, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 6을 참조하여 넘버링된다.
본 발명은 또한
Figure pct00025
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00026
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00027
및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 22를 참조하여 넘버링된다.
본 발명은 또한 240, 370, 385, 539, 540, 550/575, 634 및 777, 및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 240A, 370T, 385L, 539V, 540G, 540Q, 550S/575Q, 634R, 및 777D, 및 743P, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 R240A, L370T, P385L, I539V, K540G, K540Q, V550S/R575Q, K634R, 및 T777D, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 24를 참조하여 넘버링된다.
본 발명은 또한 390/391, 482 및 515, 및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 390Q/391G, 482Q, 515F, 및 515L, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 Y390Q/K391G, K482Q, K515F, 및 K515L, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다.
본 발명은 또한 281, 281/579, 및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 281I 및 281I/579A, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는 C281I 및 C281I/N579A, 및/또는 이들의 임의의 조합으로부터 선택되며, 여기서 아미노산 위치는 서열번호 28을 참조하여 넘버링된다.
본 발명은 또한
Figure pct00028
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 824를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00029
로부터 선택되며, 여기서 아미노산 위치는 서열번호 824를 참조하여 넘버링된다. 일부 추가의 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00030
로부터 선택되며, 여기서 아미노산 위치는 서열번호 824를 참조하여 넘버링된다.
본 발명은 또한
Figure pct00031
및/또는 이들의 임의의 조합으로부터 선택된 위치(들)에서 적어도 하나의 치환 또는 치환 세트를 포함하는 조작된 DNA 중합효소를 제공하며, 여기서 아미노산 위치는 서열번호 824를 참조하여 넘버링된다. 일부 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00032
로부터 선택되며, 여기서 아미노산 위치는 서열번호 824를 참조하여 넘버링된다. 일부 추가의 실시 양태에서, 적어도 하나의 치환 또는 치환 세트는
Figure pct00033
로부터 선택되며, 여기서 아미노산 위치는 서열번호 824를 참조하여 넘버링된다.
본 발명은 또한 표 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.1, 4.2, 4.3, 4.4, 4.5, 6.2 및/또는 6.3에 제시된 적어도 하나의 조작된 DNA 중합효소 변이체의 서열과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상 동일한 폴리펩티드 서열을 포함하는 조작된 DNA 중합효소를 제공한다. 일부 실시 양태에서, 조작된 DNA 중합효소는 DNA 중합효소 활성을 갖는다. 일부 실시 양태에서, 조작된 DNA 중합효소는 야생형 DNA 중합효소와 비교하여 적어도 하나의 개선된 특성을 갖는다. 일부 실시 양태에서, 야생형 DNA 중합효소는 피로코쿠스 퓨리오수스(Pyrococcus furiosus)의 Pfu DNA 중합효소, 테르모코쿠스 종(Thermococcus sp.) 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스(Thermus aquaticus)의 Taq DNA 중합효소로부터 선택된다. 일부 실시 양태에서, 조작된 DNA 중합효소는 야생형 DNA 중합효소와 비교하여 적어도 하나의 개선된 특성을 가지며, 여기서 개선된 특성은 중합효소 연쇄 반응에서 증가된 생성물의 생산, 더 큰 충실도, 및 더 큰 열안정성으로부터 선택된다. 일부 실시 양태에서, 조작된 DNA 중합효소는 중합효소 연쇄 반응에서 야생형 DNA 중합효소보다 더 생산량을 생산한다. 일부 실시 양태에서, 야생형 DNA 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택된다. 일부 추가 실시 양태에서, 조작된 DNA 중합효소는 야생형 DNA 중합효소보다 큰 충실도를 나타낸다. 일부 실시 양태에서, 야생형 DNA 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택된다. 일부 추가 실시 양태에서, 조작된 DNA 중합효소는 야생형 DNA 중합효소보다 큰 열안정성을 나타낸다. 일부 추가 실시 양태에서, 야생형 DNA 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택된다. 일부 추가 실시 양태에서, 조작된 DNA 중합효소는 정제된다.
본 발명은 또한 본원에 제공된 조작된 DNA 중합효소를 코딩하는 폴리뉴클레오티드 서열을 제공한다. 일부 실시 양태에서, 폴리뉴클레오티드 서열은 본원에 제공된 적어도 하나의 조작된 DNA 중합효소를 코딩한다. 일부 추가의 실시 양태에서, 폴리뉴클레오티드 서열은 서열번호 1, 5, 21, 23, 25, 27 및/또는 823의 참조 서열 또는 이의 기능적 단편과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 서열 동일성을 포함하며, 여기서 조작된 폴리펩티드는 하나 이상의 아미노산 위치에서 적어도 하나의 치환을 포함한다. 일부 추가 실시 양태에서, 폴리뉴클레오티드 서열은 서열번호 2, 6, 22, 24, 26, 28 및/또는 824의 참조 서열과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 서열 동일성을 갖는 서열을 포함하는 적어도 하나의 조작된 DNA 중합효소를 코딩한다. 일부 추가 실시 양태에서, 폴리뉴클레오티드 서열은 서열번호 1, 5, 21, 23, 25, 27 및/또는 823을 포함한다. 일부 추가 실시 양태에서, 폴리뉴클레오티드 서열은 제어 서열에 작동 가능하게 연결된다. 일부 추가 실시 양태에서, 폴리뉴클레오티드 서열은 코돈-최적화된다.
본 발명은 또한 본원에 제공된 적어도 하나의 폴리뉴클레오티드 서열을 포함하는 발현 벡터를 제공한다. 본 발명은 또한 본원에 제공된 적어도 하나의 발현 벡터로 형질전환된 숙주 세포를 제공한다.
본 발명은 또한 적어도 하나의 조작된 DNA 중합효소가 생산되도록 적절한 배양 조건하에서 본원에 제공된 숙주 세포를 배양하는 단계를 포함하는 숙주 세포에서 조작된 DNA 중합효소 폴리펩티드를 생산하는 방법을 제공한다. 일부 실시 양태에서, 방법은 배양물 및/또는 숙주 세포로부터 적어도 하나의 조작된 DNA 중합효소를 회수하는 단계를 추가로 포함한다. 일부 추가 실시 양태에서, 방법은 적어도 하나의 조작된 DNA 중합효소를 정제하는 단계를 추가로 포함한다. 본 발명은 또한 본원에서 제공된 적어도 하나의 조작된 DNA 중합효소를 포함하는 조성물을 제공한다.
본 발명은 또한 DNA 중합효소 충실도를 결정하기 위한 고-처리량 분석 시스템을 제공한다. 본 발명은 또한 DNA 중합효소의 고-처리량 충실도 결정 방법으로서, i) 적어도 하나의 DNA 중합효소; 제1 리포터 단백질 및 제2 리포터 단백질 및 선별 마커를 코딩하는 유전자를 포함하는 리포터 플라스미드; 중합효소 연쇄 반응을 수행하기 위한 열 순환기 및 시약을 포함하는 증폭 시스템; 및 정제 시스템; 적격 숙주 세포를 포함하는 형질전환 시스템; 및 유세포 분석기를 제공하는 단계; ii) 리포터 구축물이 DNA 중합효소에 의해 증폭되어 PCR 생성물을 생산하도록 하는 조건하에서 DNA 중합효소 및 리포터 플라스미드를 증폭 시스템에 노출시키는 단계; iii) PCR 앰플리콘을 원형화하여 원형화된 PCR 앰플리콘을 제공하는 단계; vi) 형질전환 시스템을 이용하여 PCR 앰플리콘을 형질전환시켜 형질전환된 세포를 생산하는 단계; 및 vii) 유세포 분석기를 사용하여 형질전환된 세포를 분석하는 단계; 및 viii) DNA 중합효소의 충실도를 결정하는 단계를 포함하는 방법을 제공한다. 일부 실시 양태에서, 방법은 본원에 제공된(예를 들어, 임의의 실시예 및 표에 제공된 바와 같은) 적어도 하나의 DNA 중합효소를 포함한다. 일부 실시 양태에서, 방법은 형질전환된 세포를 유도하는 단계를 추가로 포함한다. 일부 추가 실시 양태에서, 제1 리포터 단백질은 녹색 형광 단백질을 포함한다. 일부 추가 실시 양태에서, 제2 리포터 단백질은 dsRed를 포함한다. 추가 실시 양태에서, 선별 마커는 클로람페니콜 아세틸트랜스퍼라아제를 포함한다. 일부 추가 실시 양태에서, PCR 앰플리콘의 원형화는 적어도 하나의 리가아제를 사용하여 수행된다. 일부 실시 양태에서, PCR 앰플리콘은 정제된다. 일부 추가 실시 양태에서, 방법은 참조 DNA 중합효소와 비교하여 중합효소 충실도의 개선 배수를 결정하는 단계를 추가로 포함한다. 일부 실시 양태에서, 참조 DNA 중합효소는 야생형 중합효소이다. 일부 추가의 실시 양태에서, 야생형 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택된다. 일부 실시 양태에서, 각 변이체에 대한 상대 오류율은 변이체에 대한 제1 형광 단백질(예를 들어, 녹색 단독) 빈도를 부모 대조군에 대한 빈도로 나눔으로써 계산한다. 일부 추가 실시 양태에서, 중합효소 충실도의 개선 배수를 보고하고 상대 오류율을 결정한다.
[도 1]은 실시예 5에 기재된 바와 같이 테스트된 중합효소의 상대 오류율을 보여주는 그래프를 제공한다.
[도 2]는 GC 함량이 낮은 유기체(스태필로코쿠스 에피더미디스(Staphylococcus epidermidis), 32% GC)에 대한 미생물 전체 게놈 리시퀀싱(resequencing)에 대한 커버리지의 균일성을 보여주는 그래프를 제공한다. 정규화된 커버리지는 각 게놈에 대한 GC 함량의 함수로서 플로팅된다. 정규화된 커버리지에 대한 이론적 이상(ideal)은 점선(1.0)으로 플로팅된다.
[도 3]은 GC 함량이 높은 유기체(로도박터 스페로이데스(Rhodobacter sphaeroides), 69% GC)에 대한 미생물 전체 게놈 리시퀀싱에 대한 커버리지의 균일성을 보여주는 그래프를 제공한다. 정규화된 커버리지는 각 게놈에 대한 GC 함량의 함수로서 플로팅된다. 정규화된 커버리지에 대한 이론적 이상은 점선(1.0)으로 플로팅된다.
본 발명은 조작된 DNA 중합효소 폴리펩티드 및 이의 조성물, 뿐만 아니라 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 제공한다. 본 발명은 또한 진단 및 기타 목적을 위해 조작된 DNA 중합효소 폴리펩티드를 포함하는 조성물의 사용 방법을 제공한다. 일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드는 특히 낮은 농도의 DNA 입력, 고-처리량 분석 및/또는 시퀀싱 반응을 포함하는 조건하에서 높은 복제 충실도를 갖는 향상된 중합 활성을 제공하도록 최적화된다. 일부 실시 양태에서, 본 발명은 진단 및 연구 목적을 위해 조작된 DNA 중합효소를 포함하는 방법 및 조성물을 제공한다. 본 발명은 또한 조작된 DNA 중합효소 폴리펩티드, 이의 돌연변이체, 생물학적 활성 단편 및 유사체, 및 이를 포함하는 조성물을 제공한다.
일부 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 무세포 DNA, 순환 종양 DNA, 순환 종양 세포로부터 단리된 DNA, 순환 태아 DNA, 바이러스에 감염된 세포로부터 단리된 DNA, 미세 바늘 흡인물, 또는 FACS(fluorescence activated cell sorting: 형광 활성화 세포 분류), 레이저 캡처 현미경, 또는 미세 유체 장치에 의해 단리된 단일 세포를 포함하는 환자 샘플로부터 소량의 DNA를 사용하는 진단 및 연구 적용에 사용된다. 그러나 본 발명에서는 DNA 농도가 낮은 샘플을 포함한 임의의 적합한 샘플이 사용되기 때문에 본 발명과 함께 사용되는 샘플은 임의의 특정 샘플 유형에 제한되는 것으로 의도되지 않는다.
일부 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 중간 농도 내지 고농도 DNA 샘플을 위한 DNA 시퀀싱 라이브러리의 구축에 사용된다.
일부 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 분자 클로닝 적용, 특히 자연 발생 효소의 Km에 비해 DNA 농도가 낮은 분자 클로닝 적용에 사용된다. 일부 실시 양태에서, 이는 샘플이 소량으로 준비되는 고-처리량 클로닝 적용, 또는 환경 샘플, 환자 샘플, 또는 고대 DNA와 같은 임의의 저농도 DNA 샘플에 적용된다.
일부 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 작업 사이에서 정화(cleanup) 단계를 제거하는 자동화된 워크플로우를 포함하는 단순화된 분자 생물학 워크플로우에 사용된다. 조작된 DNA 중합효소는 저농도 기질에 활성을 갖기 때문에, 저해제를 힘유하는 작은 부피(또는 희석)의 기질 샘플이 결찰 반응에 첨가될 수 있다. 관련 억제제 함유 DNA 샘플에는 PCR 완충액 내 DNA, 전기영동 완충액 내 DNA, 또는 조 추출물 내 DNA가 포함될 수 있다. 본 발명의 조작된 DNA 중합효소는 천연 DNA 중합효소와 비교하여 희석된 샘플을 효율적으로 결찰할 수 있다. 대안적으로, 다른 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 저해제(들)를 함유하는 희석되지 않은 샘플에 사용된다.
일부 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 미세 유체 액적, 또는 웰 플레이트에서 수행되는 단일 포트 다중 효소 반응에 사용된다. DNA 중합효소의 높은 비활성은 반응에서 다른 효소의 성능을 위해 선택된 완충 제제를 허용하여 전체 워크플로우를 제한하지 않는 결찰 성능을 달성한다.
일부 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 DNA 라이브러리의 구축에 사용된다. 이러한 라이브러리는 DNA 시퀀싱, 고-처리량 스크리닝, 유전자 선별, 파지 디스플레이, 효모 디스플레이, 리보솜 디스플레이, 세포 기반 분석, 생화학 분석, 또는 이미징 기반 고 함량 스크리닝에 사용될 수 있다. 일부 실시 양태에서, 본 발명의 조작된 DNA 중합효소는 라이브러리 크기, 다양성 또는 충실도가 야생형 DNA 중합효소가 사용될 때 결찰 기질 농도에 의해 제한될 때 특별한 유용성을 찾는다.
약어 및 정의:
달리 정의되지 않는 한, 본원에서 사용되는 모든 기술 및 과학 용어는 일반적으로 본 발명이 속하는 기술 분야의 통상의 기술자에 의해 일반적으로 이해되는 것과 동일한 의미를 갖는다. 일반적으로, 본원에서 사용되는 명명법 및 아래에 기재된 세포 배양, 분자 유전학, 미생물학, 유기 화학, 분석 화학 및 핵산 화학의 실험 절차는 당 업계에서 잘 알려져 있고 일반적으로 사용되는 것들이다. 이러한 기술은 당업자에게 잘 알려진 수많은 문서 및 참고 문헌에 잘 알려져 있고 설명되어 있다. 화학적 합성 및 화학적 분석에 표준 기술 또는 그 변형이 사용된다.
본원, 상기 및 하기 모두에 언급된 모든 특허, 특허 출원, 논문 및 간행물은 이로써 명시적으로 본원에 참고로 명시적으로 포함된다.
본원에 기재된 것과 유사하거나 동등한 임의의 적절한 방법 및 재료가 본 발명의 실시에서 사용되지만, 일부 방법 및 재료가 본원에 기재된다. 본 발명은 기재된 특정 방법론, 프로토콜, 및 시약에 제한되지 않으며, 그 이유는 이들이 당업자에 의해 사용되는 맥락에 따라 달라질 수 있기 때문이라는 것을 이해해야 한다. 따라서, 바로 아래에 정의된 용어는 본 출원을 전체로 참조하여 더 자세히 설명된다. 본원, 상기 및 하기 모두에 언급된 모든 특허, 특허 출원, 논문 및 간행물은 이로써 명시적으로 본원에 참고로 포함된다.
본원에 사용되는 바와 같이, 단수 "a", "an" 및 "the"는 문맥상 달리 명확하게 나타내지 않는 한 복수의 언급 대상을 포함한다.
수의 범위는 범위를 정의하는 숫자를 포함한다. 따라서, 본원에 개시된 모든 수치 범위는 그러한 더 넓은 수치 범위 내에 속하는 모든 더 좁은 수치 범위를, 마치 그러한 더 좁은 수치 범위가 모두 본원에 명시적으로 기재된 것처럼 포함하도록 의도된다. 또한, 본원에 개시된 모든 최대(또는 최소) 수치 제한은 모든 더 낮은(또는 더 높은) 수치 제한을, 마치 그러한 더 낮은(또는 더 높은) 수치 제한이 본원에 명시적으로 기재된 것처럼 포함하도록 의도된다.
용어 "약"은 특정 값에 대해 허용 가능한 오류를 의미한다. 일부 예에서 "약"은 주어진 값 범위의 0.05%, 0.5%, 1.0% 또는 2.0% 이내를 의미한다. 일부 경우에, "약"은 주어진 값의 1, 2, 3, 또는 4 표준 편차 이내를 의미한다.
또한, 본원에 제공된 표제는 본 출원을 전체로 참조하여 가질 수 있는 본 발명의 다양한 측면 또는 실시 양태를 제한하는 것이 아니다. 따라서 바로 아래에 정의된 용어는 본 출원을 전체로 참조하여 보다 완전하게 정의된다. 그럼에도, 본 발명의 이해를 용이하게 하기 위해, 다수의 용어가 아래에 정의된다.
달리 표시되지 않는 한, 핵산은 5'에서 3' 방향으로 왼쪽에서 오른쪽으로 기재된다. 아미노산 서열은 각각 아미노에서 카르복시 방향으로 왼쪽에서 오른쪽으로 기재된다.
본원에 사용되는 바와 같이, 용어 "포함하는(comprising)" 및 그의 동계어는 그들의 포괄적인 의미로 사용된다(즉, 용어 "포함하는(including)" 및 그의 상응하는 동계어와 같음).
본원에 사용되는 바와 같이 "EC" 번호는 NC-IUBMB(Nomenclature Committee of the International Union of Biochemistry and Molecular Biology)의 효소 명명법을 지칭한다. IUBMB 생화학 분류는 효소가 촉매하는 화학 반응을 기반으로 한 효소에 대한 수치 분류 시스템이다.
본원에 사용되는 바와 같이, "ATCC"는 생물 저장소 수집물이 유전자 및 균주를 포함하는 American Type Culture Collection을 지칭한다.
본원에서 사용되는 바와 같이, "NCBI(National Center for Biological Information)"는 미국 국립 생물 정보 센터 및 그 안에 제공된 서열 데이터베이스를 지칭한다.
본원에 사용되는 바와 같이, 용어 "DNA"는 데옥시리보 핵산을 지칭한다.
본원에 사용되는 바와 같이, 용어 "RNA"는 리보 핵산을 지칭한다.
본원에 사용되는 바와 같이, 용어 "융합 단백질" 및 "키메라 단백질" 및 "키메라"는 원래 별개의 단백질을 코딩하는 2개 이상의 유전자의 연결을 통해 생성된 하이브리드 단백질을 지칭한다. 일부 실시 양태에서, 융합 단백질은 재조합 기술(예를 들어, 당 업계에 공지된 분자 생물학 기술)에 의해 생성된다.
본원에 사용되는 바와 같이, 용어 "중합효소"는 뉴클레오시드 트리포스페이트를 중합하는 효소 부류를 지칭한다. 중합효소는 주형 핵산 가닥을 사용하여 상보적인 핵산 가닥을 합성한다. 주형 가닥 및 합성된 핵산 가닥은 독립적으로 DNA 또는 RNA일 수 있다. 당 업계에 공지된 중합효소는 DNA 중합효소(예를 들어, 이. 콜라이 DNA polI, 티. 아쿠아티쿠스 DNA 중합효소[Taq], DNA 의존성 RNA 중합효소 및 역전사 효소)를 포함하지만 이에 제한되지 않는다. 본원에 사용되는 바와 같이, 중합효소는 중합효소의 원하는 효소 기능을 수행하기에 충분한 아미노산을 함유하는 폴리펩티드 또는 단백질이다. 일부 실시 양태에서, 중합효소는 천연 효소에서 발견되는 모든 아미노산을 함유하는 것이 아니라, 중합효소가 5'-3' 중합, 5'-3' 엑소뉴클레아제, 및 3'-5'엑소뉴클레아제 활성을 포함하지만 이에 제한되지 않는 원하는 촉매 활성을 수행하도록 허용하기에 충분한 아미노산만을 함유한다.
본원에 사용되는 바와 같이, 용어 "DNA 중합효소 활성", "합성 활성" 및 "중합효소 활성"은 본원에서 상호 교환적으로 사용되며, 데옥시뉴클레오시드 트리포스페이트의 혼입에 의해 새로운 DNA 가닥을 합성하는 효소의 능력을 지칭한다.
본원에 사용되는 바와 같이, 용어 "이중체" 및 "ds"는 서열에서 상보적인(A는 T와 쌍을 이루고, C는 G와 쌍을 이룸) 2개의 단일 가닥 폴리뉴클레오티드로 구성되고, 역평행 5'에서 3' 방향으로 배열되고, 핵 염기(즉, 아데닌[A], 구아닌[G], 시토신[C], 및 티민[T]) 사이에서 수소 결합에 의해 함께 고정된 이중 가닥 핵산(예를 들어, DNA) 분자를 지칭한다.
본원에 사용되는 바와 같이, 용어 "평활(blunt)"은 5' 또는 3' 오버행을 갖지 않는 자기 상보성을 갖는 DNA 이중체 또는 단일 가닥("ss") DNA의 말단을 지칭한다. 평활 말단은 한쪽 또는 양쪽 가닥에 5' 포스페이트를 가질 수 있으며, T4 DNA 리가아제와 같은 리가아제에 의한 결찰에 적합하다.
본원에 사용되는 바와 같이, 용어 "말단 복구"는 DNA(예를 들어, 단편화된 또는 손상된 DNA 또는 다른 DNA 분자와 적합하지 않은 DNA 분자)를 복구하는 방법을 지칭한다. 일부 실시 양태에서, 이 과정은 2가지 기능을 포함한다: 1) T4 DNA 중합효소 및/또는 클레나우(Klenow) 단편과 같은 효소에 의한 오버행이 있는 이중 가닥 DNA에서 오버행이 없는 이중 가닥 DNA로의 전환; 및 2) 폴리뉴클레오티드 키나아제와 같은 효소에 의한 DNA의 5' 말단(단일 또는 이중 가닥)에 포스페이트 기의 첨가.
"단백질", "폴리펩티드" 및 "펩티드"는 길이 또는 번역 후 변형(예를 들어, 글리코실화 또는 인산화)에 관계없이 아미드 결합에 의해 공유 결합된 2개 이상의 아미노산의 중합체를 나타내기 위해 본원에서 상호 교환적으로 사용된다.
"아미노산"은 일반적으로 알려진 3문자 기호 또는 IUPAC-IUB 생화학 명명위원회에서 권장하는 1문자 기호로 본원에서 나타낸다. 마찬가지로 뉴클레오티드는 일반적으로 허용되는 단일 문자 코드로 나타낼 수 있다. 유전자 코딩된 아미노산에 사용되는 약어는 통상적이며 다음과 같다: 알라닌(Ala 또는 A), 아르기닌(Arg 또는 R), 아스파라긴(Asn 또는 N), 아스파테이트(Asp 또는 D), 시스테인(Cys 또는 C), 글루타민(Glu 또는 E), 글루타민(Gln 또는 Q), 히스티딘(His 또는 H), 이소류신(Ile 또는 I), 류신(Leu 또는 L), 리신(Lys 또는 K), 메티오닌(Met 또는 M), 페닐알라닌(Phe 또는 F), 프롤린(Pro 또는 P), 세린(Ser 또는 S), 트레오닌(Thr 또는 T), 트립토판(Trp 또는 W), 티로신(Tyr 또는 Y), 및 발린(Val 또는 V). 3문자 약어를 사용할 때 "L" 또는 "D"가 구체적으로 선행되거나 약어가 사용되는 맥락에서 명확하지 않은 경우 아미노산은 α-탄소(Cα)에 대한 L- 또는 D- 배열일 수 있다. 예를 들어, "Ala"는 α-탄소에 대한 배열을 지정하지 않고 알라닌을 지정하는 반면, "D-Ala"와 "L-Ala"는 각각 D- 알라닌과 L- 알라닌을 지정한다. 한 문자 약어를 사용할 경우 대문자는 α-탄소에 대한 L-배열의 아미노산을 지정하고 소문자는 α- 탄소에 대한 D-배열의 아미노산을 지정한다. 예를 들어, "A"는 L-알라닌을 지정하고 "a"는 D-알라닌을 지정한다. 폴리펩티드 서열이 1문자 또는 3문자 약어(또는 이들의 혼합)의 문자열로 제공되는 경우, 서열은 일반적인 관례에 따라 아미노(N)에서 카르복시(C) 방향으로 제시된다.
유전자 코딩 뉴클레오시드에 사용되는 약어는 통상적이며 다음과 같다: 아데노신(A); 구아노신(G); 시티딘(C); 티미딘(T); 및 우리딘(U). 구체적으로 설명되지 않는 한, 축약된 뉴클레오시드는 리보뉴클레오시드 또는 2'-데옥시리보뉴클레오시드일 수 있다. 뉴클레오시드는 리보뉴클레오시드 또는 2'-데옥시리보뉴클레오시드로 개별적으로 또는 집합체로 특정될 수 있다. 핵산 서열이 한 문자 약어의 문자열로 제시되는 경우, 서열은 일반적인 관례에 따라 5'에서 3' 방향으로 제시되며 인산염은 표시되지 않는다.
용어 "조작된", "재조합", "비-자연 발생" 및 "변이체"는 세포, 폴리뉴클레오티드 또는 폴리펩티드와 관련하여 사용될 때 달리 자연에 존재하지 않는 방식으로 변형되거나 그와 동일하지만 합성 물질로부터 및/또는 재조합 기술을 사용한 조작에 의해 생산되거나 유래된 물질 또는 천연 또는 자연 형태의 물질에 상응하는 물질을 지칭한다.
본원에 사용되는 바와 같이, "야생형" 및 "자연 발생"은 자연에서 발견되는 형태를 지칭한다. 예를 들어 야생형 폴리펩티드 또는 폴리뉴클레오티드 서열은 자연의 공급원으로부터 단리될 수 있고 인간 조작에 의해 의도적으로 변형되지 않은 유기체에 존재하는 서열이다.
본원에 사용되는 바와 같이, "코딩 서열"은 단백질의 아미노산 서열을 코딩하는 핵산(예를 들어, 유전자) 부분을 지칭한다.
본원에 사용되는 바와 같이, 용어 "퍼센트(%) 서열 동일성"은 폴리뉴클레오티드 및 폴리펩티드 간의 비교를 지칭하고, 비교 창에 걸쳐 최적으로 정렬된 2개의 서열을 비교함으로써 결정되며, 여기서 비교 창에서 폴리뉴클레오티드 또는 폴리펩티드 서열의 일부는 두 서열의 최적 정렬을 위해 참조 서열과 비교하여 추가 또는 결실(즉, 갭)을 포함할 수 있다. 백분율은 두 서열에서 동일한 핵산 염기 또는 아미노산 잔기가 발생하는 위치 수를 결정하여 일치된 위치 수를 산출하고, 일치된 위치 수를 비교 창의 총 위치 수로 나누고, 결과에 100을 곱하여 서열 동일성의 백분율을 산출함으로써 계산할 수 있다. 대안적으로, 백분율은 동일한 핵산 염기 또는 아미노산 잔기가 두 서열 모두에서 발생하거나 핵산 염기 또는 아미노산 잔기가 갭과 정렬된 위치 수를 결정하여 일치된 위치 수를 산출하고, 일치된 위치의 수를 비교 창의 총 위치 수로 나누고 결과에 100을 곱하여 서열 동일성의 백분율을 산출하여 계산할 수 있다. 당업자는 두 서열을 정렬하는데 이용 가능한 확립된 많은 알고리즘이 있음을 인식한다. 비교를 위한 서열의 최적 정렬은 예를 들어 Smith 및 Waterman의 국소 상동성 알고리즘(Smith and Waterman, Adv. Appl. Math., 2:482 [1981])에 의해, Needleman 및 Wunsch의 상동성 정렬(Needleman and Wunsch, J. Mol. Biol., 48:443 [1970])에 의해, Pearson 및 Lipman의 유사성 검색 방법(Pearson and Lipman, Proc. Natl. Acad. Sci. USA 85: 2444 [1988])에 의해, 이러한 알고리즘의 컴퓨터화된 구현(예를 들어, GCG Wisconsin Software Package의 GAP, BESTFIT, FASTA, 및 TFASTA)에 의해, 또는 당 업계에 공지된 육안 검사에 의해 수행될 수 있다. 퍼센트 서열 동일성 및 서열 유사성을 결정하는 데 적합한 알고리즘의 예에는 BLAST 및 BLAST 2.0 알고리즘(예를 들어, Altschul et al., J. Mol. Biol., 215: 403-410 [1990]; 및 Altschul et al., Nucleic Acids Res., 3389-3402 [1977] 참조)이 포함되지만 이에 제한되지는 않는다. BLAST 분석을 수행하기 위한 소프트웨어는 미국 국립생물공학 정보 센터(National Center for Biotechnology Information) 웹 사이트를 통해 공개적으로 제공된다. 이 알고리즘은 먼저 데이터 서열에서 동일한 길이의 워드와 정렬될 때 일부 양수 값의 임계 값 점수 "T"를 일치시키거나 충족시키는 질의(query) 서열에서 "W" 길이의 짧은 워드를 식별하여 높은 점수 서열 쌍(HSP: high scoring sequence pair)을 식별하는 단계를 포함한다. T는 인접 워드 점수 임계 값(Altschul et al, 상기 참조)이라고 한다. 이러한 초기 인접 워드 히트는 검색을 시작하기 위한 시드(seed)로서 작용하여 그들을 포함하는 더 긴 HSP 찾는다. 그런 다음 워드 히트는 누적 정렬 점수가 증가할 수 있는 만큼 멀리 각 서열 따라 양방향으로 연장된다. 뉴클레오티드 서열의 경우 매개 변수 "M"(일치하는 잔기 쌍에 대한 보상 점수, 항상 > 0) 및 "N"(불일치 잔기에 대한 페널티 점수, 항상 <0)을 사용하여 누적 점수를 계산한다. 아미노산 서열의 경우, 점수 매트릭스를 사용하여 누적 점수를 계산한다. 다음의 경우 각 방향에서 워드 히트의 연장이 중지된다: 누적 정렬 점수가 최대 달성 값에서 "X" 양만큼 떨어질 때; 누적 점수가 하나 이상의 음수 점수 잔기 정렬의 누적으로 인해 0 이하가 될 때; 또는 두 서열의 말단에 도달될 때. BLAST 알고리즘 매개 변수 W, T 및 X는 정렬의 감도와 속도를 결정한다. BLASTN 프로그램(뉴클레오티드 서열의 경우)은 디폴트로서 워드 길이(W) 11, 기댓값(E) 10, M=5, N=-4 및 두 가닥 비교를 사용한다. 아미노산 서열의 경우, BLASTP 프로그램은 디폴트로서 워드 길이(W) 3, 기댓값(E) 10, 및 BLOSUM62 점수 매트릭스를 사용한다(예를 들어, Henikoff and Henikoff, Proc. Natl. Acad. Sci. USA 89:10915 [1989] 참조). 서열 정렬 및 % 서열 동일성의 예시적인 결정은 제공된 디폴트 매개 변수를 사용하여 GCG Wisconsin Software package(Accelrys, Madison WI)에서 BESTFIT 또는 GAP 프로그램을 사용할 수 있다.
본원에 사용되는 바와 같이, "참조 서열"은 서열 비교를 위한 기준으로 사용되는 정의된 서열을 지칭한다. 참조 서열은 더 큰 서열의 서브세트, 예를 들어 전장 유전자 또는 폴리펩티드 서열의 세그먼트일 수 있다. 일반적으로, 참조 서열은 적어도 20개 뉴클레오티드 또는 아미노산 잔기 길이, 적어도 25개 잔기 길이, 적어도 50개 잔기 길이, 적어도 100개 잔기 길이 또는 전장의 핵산 또는 폴리펩티드이다. 2개의 폴리뉴클레오티드 또는 폴리펩티드는 각각 (1) 두 서열 간에 유사한 서열(즉, 전체 서열의 일부)을 포함할 수 있고, (2) 두 서열 간에 다른 서열을 추가로 포함할 수 있기 때문에, 2개(이상)의 폴리뉴클레오티드 또는 폴리펩티드 간에 서열 비교는 전형적으로 비교 창에 걸쳐 2개의 폴리뉴클레오티드 또는 폴리펩티드의 서열을 비교하여 서열 유사성의 국소 영역을 식별하고 비교함으로써 수행된다. 일부 실시 양태에서, "참조 서열"은 1차 아미노산 서열에 기초할 수 있으며, 여기서 참조 서열은 1차 서열에서 하나 이상의 변화를 가질 수 있는 서열이다. 예를 들어, "X712에 상응하는 잔기에 발린을 갖는 서열번호 6에 기초한 참조 서열"(또는 "위치 712에 상응하는 잔기에서 발린을 갖는 서열번호 6에 기초한 참조 서열")이라는 문구는 서열번호 6의 위치 X712에서 상응하는 잔기(예를 들어, 이소류신)가 발린으로 변화된 참조 서열을 나타낸다.
본원에 사용되는 바와 같이, "비교 창"은 적어도 약 20개의 인접 뉴클레오티드 위치 또는 아미노산 잔기의 개념적 세그먼트를 지칭하며, 여기서 서열은 적어도 20개의 인접 뉴클레오티드 또는 아미노산의 참조 서열과 비교될 수 있으며 비교 창에서 서열의 일부는 두 서열의 최적 정렬을 위해 참조 서열(첨가 또는 결실을 포함하지 않음)과 비교하여 20% 이하의 첨가 또는 결실(즉, 갭)을 포함할 수 있다. 비교 창은 20개 초과의 인접 잔기일 수 있으며, 선택적으로 30, 40, 50, 100개 이상의 더 긴 창을 포함한다.
본원에 사용되는 바와 같이, 주어진 아미노산 또는 폴리뉴클레오티드 서열의 넘버링과 관련하여 사용될 때 "에 상응하는", "에 대한 참조" 및 "에 대한"은 주어진 아미노산 또는 폴리뉴클레오티드 서열이 참조 서열과 비교될 때 지정된 참조 서열의 잔기의 넘버링을 지칭한다. 즉, 주어진 중합체의 잔기 번호 또는 잔기 위치는 주어진 아미노산 또는 폴리뉴클레오티드 서열 내에서 잔기의 실제 숫자로 나타낸 위치라기보다는 참조 서열과 관련하여 표시된다. 예를 들어, 주어진 아미노산 서열, 예컨대 조작된 DNA 중합효소의 서열은 두 서열 사이의 잔기 일치를 최적화하기 위해 갭을 도입함으로써 참조 서열에 정렬될 수 있다. 이러한 경우, 갭이 존재하더라도, 주어진 아미노산 또는 폴리뉴클레오티드 서열에서 잔기의 넘버링은 그것이 정렬된 참조 서열에 대해 이루어진다. 일부 실시 양태에서, 서열은 (예를 들어 히스티딘 태그로) 태그된다.
본원에 사용되는 바와 같이, "돌연변이"는 핵산 서열의 변경을 의미한다. 일부 실시 양태에서, 돌연변이는 (즉, 돌연변이가 없는 원래 서열과 비교하여) 코딩된 폴리펩티드 서열에 변화를 초래한다. 일부 실시 양태에서, 돌연변이는 상이한 아미노산이 생성되도록 하는 치환(예를 들어, 아스파르트산을 트립토판으로 치환)을 포함한다. 일부 대안적인 실시 양태에서, 돌연변이는 아미노산이 원래의 폴리펩티드 서열에 첨가되도록 첨가를 포함한다. 일부 추가 실시 양태에서, 돌연변이는 아미노산이 원래의 폴리펩티드 서열로부터 결실되도록 결실을 포함한다. 주어진 서열에 임의의 수의 돌연변이가 존재할 수 있다.
본원에 사용되는 바와 같이, "아미노산 차이" 및 "잔기 차이"는 폴리펩티드 서열의 한 위치의 아미노산 잔기에서 참조 서열의 상응하는 위치의 아미노산 잔기에 대한 차이를 지칭한다. 아미노산 차이의 위치는 일반적으로 본원에서 "Xn"으로 지칭되며, 여기서 n은 잔기 차이의 기준이 되는 참조 서열에서 상응하는 위치를 지칭한다. 예를 들어, "서열번호 824와 비교하여 위치 X15에서 잔기 차이"(또는 서열번호 824와 비교하여 위치 15에서 잔기 차이)는 서열번호 824의 위치 15에 상응하는 폴리펩티드 위치에서 아미노산 잔기의 차이를 지칭한다. 따라서, 서열번호 824의 참조 폴리펩티드의 위치 15에 아스파르트산이 있다면, "서열번호 824와 비교하여 위치 X15에서 잔기 차이"는 서열번호 824의 위치 15에 상응하는 폴리펩티드의 위치에서 아스파르트산 이외의 임의의 잔기의 아미노산 치환을 지칭한다. 본원의 대부분의 경우, 한 위치에서 특정 아미노산 잔기 차이는 "XnY"로 표시되며, 여기서 "Xn"은 (상기 기재된 바와 같이) 참조 폴리펩티드의 상응하는 상응하는 잔기 및 위치를 지정하고, "Y"는 조작된 폴리펩티드에서 발견되는 아미노산의 단일 문자 식별자(즉, 참조 폴리펩티드에서와 상이한 잔기)이다. 일부 경우에(예를 들어 실시예의 표에서), 본 개시 내용은 또한 통상적인 표기 "AnB"로 표시되는 특정 아미노산 차이를 제공하는데, 여기서 A는 참조 서열에서 잔기의 단일 문자 식별자이고, "n"은 참조 서열에서 잔기 위치의 번호이고 B는 조작된 폴리펩티드의 서열에서 잔기 치환의 단일 문자 식별자이다. 일부 경우에, 본 개시 내용의 폴리펩티드는 참조 서열에 대한 하나 이상의 아미노산 잔기 차이를 포함할 수 있으며, 이는 참조 서열에 대한 잔기 차이가 존재하는 지정된 위치의 목록으로 표시된다. 하나 초과의 아미노산이 폴리펩티드의 특정 잔기 위치에 사용될 수 있는 일부 실시 양태에서, 사용될 수 있는 다양한 아미노산 잔기는 "/"로 구분된다(예를 들어, X775F/X775G, X775F/G, 또는 K775F/G). 본 개시 내용은 서열에 보존적 및 비보존적 아미노산 치환 중 하나/또는 둘 모두뿐만 아니라 아미노산의 삽입 및 결실(예를 들어, 위치 784에서의 결실)을 포함하는 하나 이상의 아미노산 차이를 포함하는 조작된 폴리펩티드 서열을 포함한다.
본원에 사용되는 바와 같이, 용어 "아미노산 치환 세트" 또는 "치환 세트"는 폴리펩티드 서열 내의 아미노산 치환 그룹을 지칭한다. 일부 실시 양태에서, 치환 세트는 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15개 이상의 아미노산 치환을 포함한다. 일부 실시 양태에서, 치환 세트는 실시예의 임의의 표에 열거된 열거된 임의의 변이 DNA 중합효소 폴리펩티드에 존재하는 아미노산 치환 세트를 지칭한다. 이러한 치환 세트에서, 개별 치환은 세미콜론( ";"; 예를 들어, P567G; I569G; Y667N) 또는 슬래시("/"; 예를 들어, P567G/I569G/Y667N)로 구분된다. 일부 실시 양태에서, "치환"은 아미노산의 결실을 포함한다.
본원에 사용되는 바와 같이, "보존적 아미노산 치환"은 잔기를 유사한 측쇄를 갖는 상이한 잔기로 치환하는 것을 지칭하며, 따라서 전형적으로 폴리펩티드의 아미노산 치환을 동일한 또는 유사한 정의된 아미노산 클래스 내의 아미노산으로 치환하는 것을 포함한다. 제한이 아닌 예로서, 지방족 측쇄를 갖는 아미노산은 또 다른 지방족 아미노산으로 치환될 수 있고(예를 들어, 알라닌, 발린, 류신, 및 이소류신); 히드록실 측쇄를 갖는 아미노산은 히드록실 측쇄를 갖는 또 다른 아미노산으로 치환되고(예를 들어, 세린 및 트레오닌); 방향족 측쇄를 갖는 아미노산은 방향족 측쇄를 갖는 또 다른 아미노산으로 치환되고(예를 들어, 페닐알라닌, 티로신, 트립토판, 및 히스티딘); 염기성 측쇄를 갖는 아미노산은 염기성 측쇄를 갖는 또 다른 아미노산으로 치환되고(예를 들어, 리신 및 아르기닌); 산성 측쇄를 갖는 아미노산은 산성 측쇄를 갖는 또 다른 아미노산으로 치환되고(예를 들어, 아스파르트산 또는 글루탐산); 소수성 또는 친수성 아미노산은 각각 또 다른 소수성 또는 친수성 아미노산으로 대체된다.
본원에 사용되는 바와 같이, "비보존적 치환"은 폴리펩티드의 아미노산을 측쇄 특성이 상당히 상이한 아미노산으로 치환하는 것을 지칭한다. 비보존적 치환은 정의된 그룹 내에서라기보다 그 사이에서 아미노산을 사용할 수 있으며, (a) 치환 영역에서 펩티드 백본의 구조(예를 들어, 글리신을 프롤린으로) (b) 측쇄의 전하 또는 소수성, 및/또는 (c) 측쇄의 부피에 영향을 줄 수 있다. 제한이 아닌 예로서, 예시적인 비보존적 치환은 염기성 또는 지방족 아미노산으로 치환된 산성 아미노산; 작은 아미노산으로 치환된 방향족 아미노산; 및 소수성 아미노산으로 치환된 친수성 아미노산을 포함한다.
본원에 사용되는 바와 같이, "결실"은 참조 폴리펩티드로부터 하나 이상의 아미노산의 제거에 의한 폴리펩티드의 변형을 지칭한다. 결실은 조작된 중합효소의 효소 활성을 유지하고/거나 개선된 특성을 유지하면서 참조 폴리펩티드를 구성하는 1개 이상의 아미노산, 2개 이상의 아미노산, 5개 이상의 아미노산, 10개 이상의 아미노산, 15개 이상의 아미노산, 또는 20개 이상의 아미노산, 총 아미노산 수의 10%까지, 또는 총 아미노산 수의 20%까지의 제거를 포함할 수 있다. 결실은 폴리펩티드의 내부 부분 및/또는 말단 부분에 지시될 수 있다. 다양한 실시 양태에서, 결실은 연속적인 세그먼트를 포함할 수 있거나 불연속적일 수 있다. 결실은 "-"로 표시되며 치환 세트에 존재할 수 있다.
본원에서 사용되는 바와 같이, "삽입"은 참조 폴리펩티드로부터 하나 이상의 아미노산의 첨가에 의한 폴리펩티드의 변형을 지칭한다. 삽입은 폴리펩티드의 내부 부분, 또는 카르복시 또는 아미노 말단에 있을 수 있다. 본원에서 사용된 삽입은 당 업계에 공지된 융합 단백질을 포함한다. 삽입은 아미노산의 연속적인 세그먼트일 수 있거나 자연 발생 폴리펩티드에서 하나 이상의 아미노산에 의해 분리될 수 있다.
본원에 사용되는 바와 같이, "기능적 단편" 및 "생물학적 활성 단편"은 아미노 말단 및/또는 카르복시 말단 결실(들) 및/또는 내부 결실을 갖지만, 여기서 나머지 아미노산 서열은 비교되고 있는 서열(예를 들어, 본 발명의 전장의 조작된 DNA 중합효소)의 상응하는 위치와 동일하고, 전장 폴리펩티드의 활성을 실질적으로 모두 유지하는 폴리펩티드를 지칭한다.
본원에 사용되는 바와 같이, "단리된 폴리펩티드"는 자연적으로 동반되는 다른 오염물(예를 들어, 단백질, 지질, 및 폴리뉴클레오티드)로부터 실질적으로 분리된 폴리펩티드를 지칭한다. 이 용어는 자연 발생 환경 또는 발현 시스템(예를 들어, 숙주 세포 또는 시험관 내 합성)으로부터 제거되거나 정제된 폴리펩티드를 포함한다. 재조합 폴리펩티드는 세포 내에 존재하거나, 세포 배지에 존재하거나, 용해액 또는 단리된 제제와 같은 다양한 형태로 제조될 수 있다. 이와 같이, 일부 실시 양태에서, 본원에 제공된 재조합 DNA 중합효소는 단리된 폴리펩티드이다.
본원에 사용되는 바와 같이, "실질적으로 순수한 폴리펩티드"는 폴리펩티드 종이 존재하는 우세 종인 조성물(즉, 몰 또는 중량 기준으로 조성물에서 임의의 다른 개별 거대 분자 종보다 더 풍부함)을 지칭하며, 일반적으로 대상 종이 몰 또는 중량%로 존재하는 거대 분자 종의 약 50% 이상을 포함할 때 실질적으로 정제된 조성물이다. 일반적으로, 실질적으로 순수한 DNA 중합효소 조성물은 조성물에 존재하는 몰 또는 중량%로 모든 거대 분자 종의 약 60% 이상, 약 70% 이상, 약 80% 이상, 약 90% 이상, 약 95% 이상, 및 약 98% 이상을 포함할 것이다. 일부 실시 양태에서, 대상 종은 조성물이 본질적으로 단일 거대 분자 종으로 이루어진 본질적인 균질성(즉, 오염 물질 종은 통상적인 검출 방법에 의해 조성물에서 검출될 수 없음)으로 정제된다. 용매 종, 소분자(<500 달톤), 및 원소 이온 종은 거대 분자 종으로 간주되지 않는다. 일부 실시 양태에서, 단리된 재조합 DNA 중합효소 폴리펩티드는 실질적으로 순수한 폴리펩티드 조성물이다.
본원에 사용되는 바와 같이, "개선된 효소 특성"은 야생형 DNA 중합효소 폴리펩티드(예를 들어, 서열번호 2의 야생형 DNA 중합효소) 또는 다른 조작된 DNA 중합효소 폴리펩티드와 같은 참조 DNA 중합효소 폴리펩티드와 비교하여 임의의 효소 특성에서의 개선을 나타내는 조작된 DNA 중합효소 폴리펩티드를 지칭한다. 개선된 특성은 증가된 단백질 발현, 증가된 열 활성, 증가된 열안정성, 증가된 안정성, 증가된 효소 활성, 증가된 기질 특이성 및/또는 친화성, 증가된 비활성, 기질 및/또는 최종 생성물 억제에 대한 증가된 내성, 증가된 화학 안정성, 개선된 화학 선택성, 개선된 용매 안정성, 산성 pH에 대한 증가된 내성, 단백질 분해 활성에 대한 증가된 내성(즉, 단백질 분해에 대한 감소된 민감도), 증가된 용해도 및 변경된 온도 프로파일과 같은 특성을 포함하지만 이에 제한되지는 않는다.
본원에 사용되는 바와 같이, "증가된 효소 활성" 및 "향상된 촉매 활성"은 조작된 DNA 중합효소 폴리펩티드의 개선된 특성을 지칭하며, 이는 참조 DNA 중합효소(예를 들어, 야생형 DNA 중합효소 및/또는 다른 조작된 DNA 중합효소)와 비교하여 비활성(예를 들어, 생산된 생성물/시간/중량 단백질)의 증가 및/또는 기질의 생성물로의 전환율(예를 들어, 지정된 양의 DNA 중합효소를 사용하여 지정된 기간에 기질의 출발량에서 생성물로의 전환율)의 증가로 나타낼 수 있다. 효소 활성을 결정하는 예시적인 방법이 실시예에 제공된다. K m , V max 또는 k cat 의 고전적인 효소 특성을 포함하여 효소 활성과 관련된 어떤 특성이든지 영향받을 수 있으며, 그 변화는 효소 활성을 증가시킬 수 있다. 효소 활성의 개선은 상응하는 야생형 효소의 효소 활성의 약 1.1배에서 자연 발생 DNA 중합효소 또는 DNA 중합효소가 유래된 다른 조작된 DNA 중합효소보다 최대 2배, 5배, 10배, 20배, 25배, 50배, 75배, 100배, 150배, 200배 이상의 효소 활성까지일 수 있다.
본원에서 상호 교환적으로 사용되는 용어 "단백질 분해 활성" 및 "단백질 분해"는 단백질이 더 작은 폴리펩티드 또는 아미노산으로 분해되는 것을 지칭한다. 단백질의 분해는 일반적으로 프로테아제(프로테이나제) 효소에 의한 펩티드 결합의 가수 분해 결과이다. 프로테아제 효소는 펩신, 트립신, 키모트립신, 엘라스타제; 카르복시펩티다제 A 및 B, 및 펩티다제(예를 들어, 아미노펩티다제, 디펩티다제 및 엔테로펩티다제)를 포함하지만 이에 제한되지는 않는다.
"단백질 분해에 대한 민감도 감소" 및 "단백질 분해 민감도 감소"라는 어구는 본원에서 상호 교환적으로 사용되며, 본 발명에 따른 조작된 DNA 중합효소 폴리펩티드가 하나 이상의 프로테아제로 처리한 후 (예를 들어, 실시예에 개시된 바와 같이) 표준 분석에서 참조 DNA 중합효소에 비해 더 높은 효소 활성을 가질 것이라는 것을 의미한다.
본원에 사용되는 바와 같이, "전환"은 기질(들)의 상응하는 생성물(들)로의 효소적 전환(생물 변환)을 지칭한다. "전환율"은 지정된 조건하에서 일정 기간 내에 생성물로 전환되는 기질의 백분율을 지칭한다. 따라서, DNA 중합효소 폴리펩티드의 "효소 활성" 또는 "활성"은 지정된 기간에 기질의 생성물로의 "전환율"로서 표현될 수 있다.
본원에 사용되는 바와 같이, "혼성화 엄격도"는 핵산의 혼성화에서 세척 조건과 같은 혼성화 조건과 관련된다. 일반적으로, 혼성화 반응은 더 낮은 엄격도의 조건하에서 수행된 후, 다양하지만 더 높은 엄격도의 세척이 뒤따른다. 용어 "중등도의 엄격한 혼성화"는 표적 DNA에 대해 약 60% 동일성, 바람직하게는 약 75% 동일성, 약 85% 동일성을 갖고 표적-폴리뉴클레오티드에 대해 약 90% 초과의 동일성을 갖는 상보적 핵산에 표적 DNA가 결합하도록 허용하는 조건을 지칭한다. 예시적인 중등도의 엄격한 조건은 42℃에서 50% 포름아미드, 5Х Denhart 용액, 5Х SSPE, 0.2% SDS에서 혼성화 후 42℃에서 0.2Х SSPE, 0.2% SDS에서 세척과 동등한 조건이다. "높은 엄격도 혼성화"는 일반적으로, 정의된 폴리뉴클레오티드 서열에 대해 용액 조건하에서 결정된 열 용융 온도 T m 에서 약 10℃ 이하인 조건을 지칭한다. 일부 실시 양태에서, 높은 엄격도 조건은 65℃에서 0.018M NaCl에서 안정한 혼성체를 형성하는 핵산 서열만의 혼성화를 허용하는 조건을 지칭한다(즉, 혼성체가 65℃에서 0.018M NaCl에서 안정하지 않은 경우, 본원에서 고려되는 바와 같이 높은 엄격도 조건하에서 안정하지 않을 것임). 예를 들어, 42℃에서 50% 포름아미드, 5Х Denhart 용액, 5Х SSPE, 0.2% SDS와 동등한 조건에서 혼성화 후 65℃에서 0.1Х SSPE 및 0.1% SDS에서 세척에 의해 높은 엄격한 조건을 제공할 수 있다. 또 다른 높은 엄격도 조건은 65℃에서 0.1%(w:v) SDS를 함유하는 5X SSC에서 혼성화 및 65℃에서 0.1% SDS를 함유하는 0.1x SSC에서 세척과 동등한 조건에서 혼성화이다. 다른 높은 엄격도 혼성화 조건 및 중등도의 엄격한 조건은 상기에 인용된 참고에 기재되어 있다.
본원에 사용되는 바와 같이, "코돈 최적화"는 단백질을 코딩하는 폴리뉴클레오티드의 코돈을 코딩된 단백질이 특정 유기체에서 더 효율적으로 발현되도록 해당 유기체에서 우선적으로 사용되는 것으로 변화시키는 것을 지칭한다. 대부분의 아미노산이 "동의어" 또는 "동의" 코돈이라고 하는 여러 코돈으로 표현된다는 점에서 유전 암호가 축퇴성이지만, 특정 유기체에 의한 코돈 사용은 무작위가 아니며 특정 코돈 삼중체에 편향되어 있다는 것은 잘 알려져 있다. 이 코돈 사용 편향은 주어진 유전자, 공통 기능 또는 조상 기원의 유전자, 낮은 카피 수 단백질에 비해 고도로 발현된 단백질, 및 유기체 게놈의 응집 단백질 코딩 영역과 관련하여 더 높을 수 있다. 일부 실시 양태에서, DNA 중합효소를 코딩하는 폴리뉴클레오티드는 발현을 위해 선택된 숙주 유기체로부터의 최적 생산을 위해 코돈 최적화된다.
본원에 사용되는 바와 같이, "제어 서열"은 본 개시 내용의 폴리뉴클레오티드 및/또는 폴리펩티드의 발현에 필요하거나 유리한 모든 성분을 포함하는 것을 본원에서 지칭한다. 각 제어 서열은 폴리펩티드를 코딩하는 핵산 서열에 대해 내인성이거나 외인성일 수 있다. 이러한 제어 서열은 리더, 폴리아데닐화 서열, 프로펩티드(propeptide) 서열, 프로모터 서열, 신호 펩티드 서열, 개시 서열, 및 전사 종결자를 포함하지만 이에 제한되지는 않는다. 최소한, 제어 서열은 프로모터, 및 전사 및 번역 중지 신호를 포함한다. 일부 실시 양태에서, 제어 서열은 폴리펩티드를 코딩하는 핵산 서열의 코딩 영역과 제어 서열의 결찰을 용이하게 하는 특정 제한 부위를 도입할 목적으로 링커와 함께 제공된다.
"작동 가능하게 연결된"은 제어 서열이 관심의 폴리펩티드를 코딩하는 폴리뉴클레오티드의 발현을 지시하거나 조절하도록 관심의 폴리뉴클레오티드와 상대적인 위치에 제어 서열이 적절하게 배치된 (즉, 기능적 관계에 있는) 배열로서 본원에서 정의된다.
본원에 사용되는 바와 같이, "프로모터 서열"은 코딩 서열과 같은 관심의 폴리뉴클레오티드의 발현을 위해 숙주 세포에 의해 인식되는 핵산 서열을 지칭한다. 프로모터 서열은 관심의 폴리뉴클레오티드의 발현을 매개하는 전사 제어 서열을 포함한다. 프로모터는 돌연변이, 절두, 및 하이브리드 프로모터를 포함하여 선택한 숙주 세포에서 전사 활성을 나타내는 임의의 핵산 서열일 수 있으며, 숙주 세포와 상동성 또는 이종성인 세포 외 또는 세포 내 폴리펩티드를 코딩하는 유전자로부터 얻을 수 있다.
본원에서 사용되는 바와 같이, "적합한 반응 조건"은 본 개시 내용의 DNA 중합효소 폴리펩티드가 기질을 원하는 생성 화합물로 전환할 수 있는 효소 전환 반응 용액(예를 들어, 효소 부하량, 기질 부하량, 온도, pH, 완충제, 공용매 등의 범위)에서의 조건을 지칭한다. 예시적인 "적합한 반응 조건"은 본 발명에 제공된다(실시예 참조).
본원에 사용되는 바와 같이, "화합물 부하량" 및 "효소 부하량"에서와 같이 "부하량"은 반응 시작 시 반응 혼합물에서 성분의 농도 또는 양을 지칭한다. 효소 전환 반응 공정과 관련하여 "기질"은 DNA 중합효소 폴리펩티드가 작용하는 화합물 또는 분자를 지칭한다.
본원에 사용된 바와 같이, 효소 전환 반응 공정과 관련하여 "생성물"은 기질에 대한 DNA 중합효소 폴리펩티드의 작용의 결과로 생성되는 화합물 또는 분자를 지칭한다.
본원에 사용되는 바와 같이, "배양"은 임의의 적합한 배지(예를 들어, 액체, 겔 또는 고체)를 사용하여 적합한 조건하에서 미생물 세포 집단의 성장을 지칭한다.
재조합 폴리펩티드(예를 들어, DNA 중합효소 변이체)는 당 업계에 공지된 임의의 적합한 방법을 사용하여 생산될 수 있다. 예를 들어, 당업자에게 잘 알려진 매우 다양한 상이한 돌연변이 유발 기술이 있다. 또한, 돌연변이 유발 키트는 많은 상업용 분자 생물학 공급업체에서 구입할 수 있다. 정의된 아미노산에서 특정 치환(부위 지정), 유전자의 국소 영역에서 특정 또는 무작위 돌연변이(위치 특이적), 또는 전체 유전자에 대한 무작위 돌연변이(예를 들어, 포화 돌연변이 유발)를 만드는 방법을 사용할 수 있다. PCR, 카세트 돌연변이 유발, 유전자 합성, 오류가 발생하기 쉬운 PCR, 셔플링, 및 화학적 포화 돌연변이 유발, 또는 당 업계에 공지된 임의의 다른 적합한 방법을 사용한 단일 가닥 DNA 또는 이중 가닥 DNA의 부위 지정 돌연변이 유발을 포함하지만 이에 제한되지 않는 효소 변이체를 생성하기 위한 수많은 적합한 방법이 당 업계에 알려져 있다. DNA 및 단백질 공학에 사용되는 방법의 비 제한적인 예는 다음 특허에서 제공된다: 미국 특허 제6,117,679호; 미국 특허 제6,420,175호; 미국 특허 제6,376,246호; 미국 특허 제6,586,182호; 미국 특허 제7,747,391호; 미국 특허 제7,747,393호; 미국 특허 제7,783,428호; 및 미국 특허 제8,383,346호. 변이체가 생성된 후, 이들을 임의의 원하는 특성(예를 들어, 높거나 증가된 활성, 또는 낮거나 감소된 활성, 증가된 열 활성, 증가된 열안정성 및/또는 산성 pH 안정성 등)에 대해 스크리닝할 수 있다. 일부 실시 양태에서, "재조합 DNA 중합효소 폴리펩티드"(본원에서 "조작된 DNA 중합효소 폴리펩티드", "조작된 DNA 중합효소", "변이 DNA 중합효소" 및 "DNA 중합효소 변이체"라고도 함))가 사용된다.
본원에 사용되는 바와 같이, "벡터"는 DNA 서열을 세포에 도입하기 위한 DNA 구축물이다. 일부 실시 양태에서, 벡터는 DNA 서열에 코딩된 폴리펩티드의 적합한 숙주에서 발현을 수행할 수 있는 적합한 제어 서열에 작동 가능하게 연결된 발현 벡터이다. 일부 실시 양태에서, "발현 벡터"는 숙주 세포에서 발현을 유도하기 위해 DNA 서열(예를 들어, 전이 유전자)에 작동 가능하게 연결된 프로모터 서열을 갖고, 일부 실시 양태에서 전사 종결자 서열도 포함한다.
본원에 사용되는 바와 같이, 용어 "발현"은 전사, 전사 후 변형, 번역, 및 번역 후 변형을 포함하지만 이에 제한되지 않는 폴리펩티드의 생산에 관련된 임의의 단계를 포함한다. 일부 실시 양태에서, 용어는 또한 세포로부터 폴리펩티드의 분비를 포함한다.
본원에 사용되는 바와 같이, 용어 "생산하다"는 세포에 의한 단백질 및/또는 다른 화합물의 생산을 지칭한다. 이 용어는 전사, 전사 후 변형, 번역 및 번역 후 변형을 포함하지만 이에 제한되지 않는 폴리펩티드의 생산에 관련된 임의의 단계를 포함하는 것으로 의도된다. 일부 실시 양태에서, 용어는 또한 세포로부터 폴리펩티드의 분비를 포함한다.
본원에 사용되는 바와 같이, 아미노산 또는 뉴클레오티드 서열(예를 들어, 프로모터 서열, 신호 펩티드, 종결자 서열 등)은 두 서열이 본래 결합되지 않은 경우 작동 가능하게 연결된 다른 서열에 "이종성"이다.
본원에 사용되는 바와 같이, 용어 "숙주 세포" 및 "숙주 균주"는 본원에 제공된 DNA(예를 들어, 적어도 하나의 DNA 중합효소 변이체를 코딩하는 폴리뉴클레오티드 서열)를 포함하는 발현 벡터에 적합한 숙주를 지칭한다. 일부 실시 양태에서, 숙주 세포는 당 업계에 공지된 바와 같은 재조합 DNA 기술을 사용하여 구축된 벡터로 형질전환 또는 형질 감염된 원핵 또는 진핵 세포이다.
본원에 사용되는 바와 같이, 용어 "유사체"는 참조 폴리펩티드와 70% 초과의 서열 동일성을 갖지만 100% 미만의 서열 동일성(예를 들어, 75%, 78%, 80%, 83%, 85%, 88%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 초과 서열 동일성)을 갖는 폴리펩티드를 의미한다. 일부 실시 양태에서, 유사체는 호모아르기닌, 오르니틴 및 노르발린을 포함하지만 이에 제한되지 않는 비-천연 발생 아미노산 잔기뿐만 아니라 자연 발생 아미노산을 포함한다. 일부 실시 양태에서, 유사체는 또한 하나 이상의 D-아미노산 잔기 및 2개 이상의 아미노산 잔기 사이의 비-펩티드 연결을 포함한다.
본원에서 사용되는 바와 같이, 용어 "유효량"은 원하는 결과를 가져오기에 충분한 양을 의미한다. 당업자는 일상적인 실험을 사용하여 유효량을 결정할 수 있다.
용어 "단리된" 및 "정제된"은 자연적으로 결합되는 적어도 하나의 다른 구성 요소로부터 제거된 분자(예를 들어, 단리된 핵산, 폴리펩티드 등) 또는 다른 구성 요소를 지칭하는 데 사용된다. 용어 "정제된"은 절대적인 순도를 요구하지 않고, 오히려 상대적인 정의로서 사용된다.
본원에 사용되는 바와 같이, "조성물" 및 "제제"는 적어도 하나를 포함하는 산물을 포함한다.
본원에 사용되는 바와 같이, "무세포 DNA"는 혈류에서 자유롭게 순환하는 DNA를 지칭하며 세포에 포함되거나 세포와 연관되지 않는다. 일부 실시 양태에서, 무세포 DNA는 본래 정상 체세포 또는 생식선 세포, 암세포, 태아 세포, 미생물 세포, 또는 바이러스로부터 유래되고 방출된 DNA를 포함한다.
본원에 사용되는 바와 같이, "증폭"은 핵산 복제를 의미한다. 일부 실시 양태에서, 이 용어는 특정 주형 핵산의 복제를 의미한다.
본원에 사용되는 바와 같이, "중합효소 연쇄 반응" 및 "PCR"은 이로써 본원에 참고로 포함된 미국 특허 제4,683,195호 및 제4,6884,202호에 기재된 방법을 지칭한다. 이들 방법은 클로닝 또는 정제가 요구되지 않고 혼합물 또는 정제된 DNA에서 표적 서열의 세그먼트 또는 전체 표적 서열의 농도를 증가시키는 데 사용된다. 변성, 어닐링 및 신장의 순서는 "사이클"을 구성한다. 변성, 프라이머 어닐링, 및 중합효소 신장 단계를 여러 번 반복하여(즉, 다중 사이클을 사용하여) 고농도의 증폭된 DNA를 얻을 수 있다. 이 공정은 당 업계에 잘 알려져 있으며, 방법이 처음 기술된 이후 수년에 걸쳐 수많은 변형이 개발되었다. PCR을 사용하여 특정 표적 서열의 단일 사본을 표지된 프로브와의 혼성화, 비오틴화된 프라이머의 혼입에 이어 아비딘-효소 접합체 검출, 32P-표지된 데옥시리보뉴클레오티드 트리포스페이트(예를 들어, dCTP 또는 dATP)의 증폭된 세그먼트로의 혼입 등을 포함하지만 이에 제한되지 않는 여러 가지 다양한 방법론에 의해 검출 가능한 수준으로 증폭할 수 있다. 게놈 DNA 이외에, 증폭이 가능한 임의의 올리고뉴클레오티드 서열은 적절한 프라이머 세트에 의한 PCR을 사용하여 복제할 수 있다. PCR 생성물은 증폭을 위한 주형으로도 사용될 수 있다.
본원에서 사용되는 바와 같이, PCR과 관련하여 사용될 때 "표적"은 PCR 방법에서 사용되는 프라이머에 의해 결합된 핵산 영역을 지칭한다. "표적"은 PCR 방법에서 사용되는 샘플에 존재하는 다른 핵산으로부터 분류된다. "세그먼트"는 표적 서열 내의 핵산 영역이다.
본원에 사용되는 바와 같이, "샘플 주형"은 표적 핵산의 존재에 대해 분석되는 샘플에서 유래한 핵산을 지칭한다. 대조적으로, "배경 주형"은 샘플 내에 존재하거나 존재하지 않을 수 있는 샘플 주형 이외의 핵산을 지칭한다. 배경 주형은 샘플에 우연히 포함될 수 있으며, 캐리 오버로 인한 것일 수도 있거나, 표적 핵산이 정제된 핵산 오염 물질의 존재로 인한 것일 수 있다. 예를 들어, 일부 실시 양태에서, 검출될 것 이외의 유기체로부터의 핵산은 테스트 샘플에서 배경으로서 존재할 수 있다. 그러나 본 발명이 어떠한 특정 핵산 샘플 또는 주형으로 제한되는 것으로 의도되지 않는다.
본원에 사용되는 바와 같이, "증폭 가능한 핵산"은 PCR을 포함하지만 이에 제한되지 않는 임의의 증폭 방법에 의해 증폭될 수 있는 핵산과 관련하여 사용된다. 대부분의 실시 양태에서, 증폭 가능한 핵산은 샘플 주형을 포함한다.
본원에 사용되는 바와 같이, "PCR 생성물", "PCR 단편" 및 "증폭 생성물"은 전형적으로 변성, 어닐링, 및 신장 단계를 포함하는 2 사이클 이상의 PCR 증폭(또는 문맥에 의해 지시된 바와 같은 다른 증폭 방법) 후에 수득한 결과 화합물을 지칭한다. 용어는 하나 이상의 표적 서열의 하나 이상의 세그먼트가 증폭된 상황을 포함한다.
본원에 사용되는 바와 같이, "증폭 시약" 및 "PCR 시약"은 프라이머, 핵산 주형, 및 증폭 효소를 제외하고 증폭에 필요한 시약(예를 들어, 데옥시리보뉴클레오티드 트리포스페이트, 완충액 등)을 지칭한다. 전형적으로, 증폭 시약은 다른 반응 성분과 함께 반응 용기(예를 들어, 테스트 튜브, 마이크로 웰 등)에 배치되고 포함된다. 임의의 적합한 시약이 본 발명에서 사용되는 것으로 본 발명이 임의의 특정 증폭 시약으로 제한되는 것으로 의도되지 않는다.
본원에 사용되는 바와 같이, "제한 엔도뉴클레아제" 및 "제한 효소"는 특정 뉴클레오티드 서열(즉, "제한 부위")에서 또는 그 근처에서 이중 가닥 핵산을 절단하는 효소를 지칭한다. 일부 실시 양태에서, 제한 효소는 박테리아 효소이고 일부 추가 실시 양태에서 핵산은 DNA이다.
본원에 사용되는 바와 같이, "프라이머"는 자연 발생이거나 합성, 재조합 또는 증폭에 의해 생산된 올리고뉴클레오티드(즉, 뉴클레오티드 서열)로서, 핵산 가닥에 상보적인 프라이머 신장 생성물의 합성이 유도되는 조건하에(즉, 뉴클레오티드 및 DNA 중합효소와 같은 유도제의 존재하에 적절한 온도 및 pH에) 배치되는 경우 핵산 합성의 개시 지점으로 작용할 수 있는 것을 지칭한다. 대부분의 실시 양태에서, 프라이머는 단일 가닥이지만 일부 실시 양태에서, 이중 가닥이다. 일부 실시 양태에서, 프라이머는 DNA 중합효소의 존재하에 신장 생성물의 합성을 프라이밍하기에 충분한 길이이다. 정확한 프라이머 길이는 당업자에게 알려진 바와 같이 많은 요인에 따라 달라진다.
본원에 사용되는 바와 같이, "프로브"는 자연 발생이거나 합성, 재조합 또는 증폭에 의해 생산된 올리고뉴클레오티드(즉, 뉴클레오티드 서열)로서, 관심의 다른 올리고뉴클레오티드에 혼성화할 수 있는 것을 지칭한다. 프로브는 관심의 특정 유전자 서열의 검출, 식별, 및/또는 단리에 사용된다. 일부 실시 양태에서, 프로브는 적합한 검출 시스템(예를 들어, 형광, 방사성, 발광, 효소, 및 기타 시스템)에서 프로브의 검출을 돕는 "리포터 분자"("표지"라고도 함)로 표지된다. 본 발명이 어떠한 특정 검출 시스템 또는 표지로 제한되는 것으로 의도되지 않는다. 프라이머, 데옥시리보뉴클레오티드, 및 데옥시리보뉴클레오시드는 표지를 포함할 수 있다. 실제로, 본 발명의 표지된 조성물은 어떠한 특정 성분으로 제한되는 것으로 의도되지 않는다. 예시적인 표지는 32P, 35S, 및 형광 분자(예를 들어, 녹색 형광 단백질을 포함하자만 이에 제한되지 않는 형광 염료)를 포함하지만 이에 제한되지는 않는다.
본원에서 사용되는 바와 같이, 중합효소와 관련하여 사용될 때 "충실도"는 주형 가닥에 대한 합성된 DNA 가닥에서 상보성 염기의 주형 지시된 혼입의 정확성을 지칭하는 것으로 의도된다. 전형적으로, 충실도는 새로 합성된 핵산 가닥에 잘못된 염기가 혼입된 빈도를 기준으로 측정된다. 잘못된 염기가 혼입되면 점 돌연변이, 삽입, 또는 결실이 발생할 수 있다. 충실도는 당 업계에 알려진 임의의 방법에 따라 계산될 수 있다(예를 들어, Tindall and Kunkel, Biochem., 27:6008-6013 [1988]; 및 Barnes, Gene 112:29-35 [1992] 참조). 중합효소 또는 중합효소 변이체는 고 충실도 또는 저 충실도를 나타낼 수 있다. 본원에 사용되는 바와 같이, "고 충실도"는 미리 결정된 값을 초과하는 정확한 염기 혼입 빈도를 갖는 중합효소를 지칭한다. 본원에서 사용되는 바와 같이, 용어 "저 충실도"는 미리 결정된 값보다 낮은 정확한 염기 혼입 빈도를 갖는 중합효소를 지칭한다. 일부 실시 양태에서, 미리 결정된 값은 정확한 염기 혼입의 원하는 빈도 또는 공지된 중합효소(즉, 참조 중합효소)의 충실도이다.
본원에 사용되는 바와 같이, "변경된 충실도"는 중합효소 변이체가 유래된 모 중합효소의 충실도와 상이한 중합효소 변이체의 충실도를 지칭한다. 일부 실시 양태에서, 변경된 충실도는 모 중합효소의 충실도보다 높지만, 일부 다른 실시 양태에서, 변경된 충실도는 모 중합효소의 충실도보다 낮다. 변경된 충실도는 모 및 변이 중합효소를 분석하고 당 업계에 공지된 임의의 적합한 분석을 사용하여 이들의 활성을 비교함으로써 결정될 수 있다.
본원에 사용되는 바와 같이, 용어 "리가아제"는 폴리뉴클레오티드를 함께 연결하거나 단일 폴리뉴클레오티드의 말단을 연결하기 위해 일반적으로 사용되는 효소 부류를 지칭한다. 리가아제는 ATP 의존성 이중 가닥 폴리뉴클레오티드 리가아제, NAD+ 의존성 이중 가닥 DNA 또는 RNA 리가아제 및 단일 가닥 폴리뉴클레오티드 리가아제를 포함한다. 일부 실시 양태에서, 본 발명은 박테리오파지 리가아제(예를 들어, T3 DNA 리가아제, T4 DNA 리가아제, 및 T7 DNA 리가아제) 및 이의 변이체를 제공한다. 일부 추가 실시 양태에서, 본 발명은 융합 또는 키메라 리가아제를 제공한다. DNA 리가아제는 종종 DNA 단편(예를 들어, 유전자)을 플라스미드에 삽입하기 위해 제한 효소와 함께 사용된다. 돌출 말단 단편의 결찰의 경우, 효율적인 재조합을 수행하는 데 최적의 온도를 제어하는 것이 중요하다. T4 DNA 리가아제는 37℃에서 가장 활성적이지만 돌출 말단 단편과 최적의 결찰 효율을 위해 효소의 최적 온도는 결찰되는 말단의 용융 온도와 균형을 이루어야 한다. 오버행이 짧을수록 단편의 용융 온도가 낮아진다. 결찰 반응은 돌출 말단이 이미 안정적으로 어닐링되었을 때 가장 효율적인 경향이 있다. 평활 말단 DNA 단편의 결찰의 경우, 결찰에 사용되는 정상 온도 범위 내에서 반응이 발생할 때 용융 온도는 고려할 요소가 아니다. 이러한 반응에서, 제한 요소는 리가아제 활성이라기보다는 발생할 수 있는 DNA 단편 말단 사이의 정렬 수이다. 따라서, 평활 말단 DNA 단편의 결찰을 위한 가장 효율적인 온도는 반응에서 가장 많은 수의 정렬이 발생할 수 있는 온도이다.
본원에 사용되는 바와 같이, 용어 "어댑터"는 결찰을 위해 적합성 DNA 말단을 갖는 단일 또는 이중 가닥 올리고뉴클레오티드를 의미한다. 어댑터의 말단은 단일 또는 이중 가닥일 수 있으며, 처리된 라이브러리 삽입 DNA의 상보적 오버행과 적합성 오버행을 포함할 수 있다. 어댑터에는 단일 가닥 및 이중 가닥 영역이 모두 있을 수 있다. 일부 실시 양태에서, 용어 "어댑터"는 프라이머 결합 부위, 바코드 및 기타 특징을 포함할 수 있는 NGS(next-generation sequencing)(즉, 차세대 시퀀싱) 반응에 사용되는 전장의 어댑터를 지칭할 뿐만 아니라, 전장의 어댑터와 동일한 결찰 적합성 말단을 갖지만 추가의 특징이 결여된, HTP 스크리닝 및 결찰 분석에 사용되는 단순화된 모델 어댑터를 지칭하는데 사용된다. Illumina® 시퀀싱 플랫폼에서 사용하도록 설계된 NGS 어댑터에는 A-꼬리 삽입 단편에 존재하는 데옥시아데닌 3 '오버행과의 결찰에 적합한 데옥시티민 3' 오버행이 있다. T-꼬리 어댑터는 비상보성 DNA 말단에 대한 야생형 T4 DNA 리가아제의 선택성으로 인해 서로 효율적으로 결찰되지 않는다. 긴 인큐베이션 기간, 높은 어댑터 농도, 또는 고농도의 크라우딩제(crowding agent)를 포함한 극단적인 결찰 조건의 결과로 어댑터 이량체화가 발생한다. 중요하게는, 결찰 반응의 뉴클레아제 오염 물질이 어댑터 말단의 오버행을 제거하여 자기 결찰에 적합성인 평활 말단 기질을 생성할 수 있다.
본원에 사용되는 바와 같이, 용어 "적합성 말단"은 오버행상의 모든 염기가 상보적이도록 5'에서 3'으로의 역평행 방향으로 혼성화되는 5' 또는 3' 오버행을 갖는 2개의 DNA 이중체 단편의 말단을 지칭한다. 결찰의 맥락에서, 적어도 하나의 DNA 단편은 3' 또는 5' 오버행의 혼성화 시 다른 분자의 뉴클레오티드의 3' 히드록실에 인접하게 배치된 뉴클레오티드에 5' 포스페이트를 가져야 한다. 결찰은 적합성 말단에서 두 기질 분자의 공유 결합을 초래한다. DNA 시퀀싱을 위한 라이브러리 제조를 포함하는 일부 실시 양태에서, 어댑터 및 삽입 단편과 같은 2개의 DNA 분자는 적합성 말단을 가져야 하며, PCR을 통한 생산적인 라이브러리 증폭 또는 어댑터에 혼성화되는 프라이머의 중합효소 신장에 의한 시퀀싱을 가능하게 하기 위해 어댑터/삽입체 하이브리드의 두 가닥이 모두 결찰되어야 한다.
본원에 사용되는 바와 같이, 용어 "오버행"은 이중 가닥 DNA 단편의 말단에서 발생하는 쌍을 이루지 않은 하나 이상의 폴리뉴클레오티드의 영역을 지칭한다. 5 '또는 3' DNA 말단은 쌍을 이루지 않은 영역에 존재할 수 있다. 이중 가닥 DNA 단편은 2개의 상보적인 단일 가닥 폴리뉴클레오티드의 이중체일 수 있거나, 이중 가닥 DNA 영역을 형성하는 자기 상보성을 갖는 단일 폴리뉴클레오티드일 수 있다.
용어 "대상체"는 인간, 비인간 영장류, 가축, 반려 동물, 및 실험실 동물(예를 들어, 설치류 및 라가모프(lagamorph))과 같은 포유동물을 포함한다. 이 용어는 남성뿐만 아니라 여성도 포함하도록 의도된다.
본원에 사용되는 바와 같이, 용어 "환자"는 질환에 대해 평가되고 있거나, 치료되거나, 경험하고 있는 임의의 대상체를 의미한다.
조작된 DNA 중합효소 폴리펩티드
특정 DNA 중합효소 변이체(즉, 조작된 DNA 중합효소 폴리펩티드)가 야생형 DNA 중합효소 또는 참조 DNA 중합효소의 서열에서 특정 아미노산 잔기의 변형과 관련하여 언급되는 경우, 등가 위치(들)(각 아미노산 서열 사이의 선택적 아미노산 서열 정렬로부터 결정됨)에서 변형된 다른 DNA 중합효소의 변이체가 본원에 포함됨을 이해해 한다.
중합효소 연쇄 반응(PCR) 및 DNA를 생산하기 위해 중합효소를 이용하는 다른 반응에 유용한 것들을 포함하여 본 발명의 조작된 DNA 중합효소 폴리펩티드 변이체가 중합효소 반응을 수행한다.
본 발명의 조작된 DNA 중합효소 변이체는 NGS 및 다른 진단 방법에 적합한 DNA 라이브러리의 효율적인 생성에 사용된다. 이러한 DNA 중합효소 변이체는 용액에서뿐만 아니라 고정된 실시 양태에서도 사용된다.
일부 추가 실시 양태에서, 본 발명의 조작된 DNA 중합효소 폴리펩티드는 서열번호 2, 6, 22, 24, 26, 28 및/또는 824와 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 91%, 적어도 92%, 적어도 93%, 적어도 94%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 또는 적어도 99% 서열 동일성을 포함하는 폴리펩티드를 포함한다.
일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드는 조작된 DNA 중합효소 폴리펩티드를 생산하는 데 도움이 되는 조건하에서 적어도 하나의 조작된 DNA 중합효소 폴리펩티드를 코딩하는 적어도 하나의 폴리뉴클레오티드 서열을 포함하는 미생물을 배양함으로써 생산된다. 일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드는 후속적으로, 생성된 배양 배지 및/또는 세포로부터 회수된다.
본 발명은 DNA 중합효소 활성을 갖는 예시적인 조작된 DNA 중합효소 폴리펩티드를 제공한다. 실시예는 특정 아미노산 서열 특징을 조작된 DNA 중합효소 폴리펩티드의 기능적 활성과 관련시키는 서열 구조 정보를 보여주는 표를 제공한다. 이 구조-기능 상관관계 정보는 서열번호 2, 6, 22, 24, 26, 28 및/또는 824의 참조의 조작된 폴리펩티드에 대해 특정 아미노산 잔기 차이의 형태뿐만 아니라 예시적인 조작된 DNA 중합효소 폴리펩티드에 대한 연관된 실험적으로 결정된 활성 데이터로 제공된다.
일부 실시 양태에서, DNA 중합효소 활성을 갖는 본 발명의 조작된 DNA 중합효소 폴리펩티드는 참조 서열인 서열번호 2, 6, 22, 24, 26, 28 및/또는 824와 적어도 85% 서열 동일성을 갖고 참조 서열(예를 들어, 야생형 DNA 중합효소)과 비교하여 적어도 하나의 개선된 특성을 나타내는 아미노산 서열을 포함한다. 일부 실시 양태에서, 개선된 특성은 PCR 동안 생산된 증가된 생성물인 반면, 일부 추가 실시 양태에서 개선된 특성은 증가된 충실도이고, 또 다른 일부 추가 실시 양태에서, 개선된 특성은 증가된 열안정성이다.
일부 실시 양태에서, 적어도 하나의 개선된 특성을 나타내는 조작된 DNA 중합효소 폴리펩티드는 서열번호 2, 6, 22, 24, 26, 28 및/또는 824와 적어도 85%, 적어도 88%, 적어도 90%, 적어도 91%, 적어도 92%, 적어도 93%, 적어도 94%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 적어도 99% 이상의 아미노산 서열 동일성, 및 서열번호 2, 6, 22, 24, 26, 28 및/또는 824와 비교하여 하나 이상의 아미노산 위치(예컨대 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 20개 이상의 아미노산 위치)에서 아미노산 잔기 차이를 갖는다. 일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드는 실시예에 제공된 표(예를 들어, 표 3.1, 3.2, 3.3. 3.4, 3.5, 3.6, 3.7, 3.8, 4.1, 4.2, 4.3, 4.4, 4.5, 6.2 및/또는 6.3)에 나열된 폴리펩티드이다.
일부 실시 양태에서, 본 발명은 조작된 DNA 중합효소 폴리펩티드의 기능적 단편을 제공한다. 일부 실시 양태에서, 기능적 단편은 그가 유래된 조작된 DNA 중합효소 폴리펩티드(즉, 모 조작된 DNA 중합효소)의 활성의 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%를 포함한다. 일부 실시 양태에서, 기능적 단편은 조작된 DNA 중합효소의 모 서열의 적어도 약 90%, 적어도 약 91%, 적어도 약 92%, 적어도 약 93%, 적어도 약 94%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%를 포함한다. 일부 실시 양태에서 기능적 단편은 5개 미만, 10개 미만, 15개 미만, 10개 미만, 25개 미만, 30개 미만, 35개 미만, 40개 미만, 45개 미만, 및 50개 미만의 아미노산만큼 절두될 것이다.
일부 실시 양태에서, 본 발명은 조작된 DNA 중합효소 폴리펩티드의 기능적 단편을 제공한다. 일부 실시 양태에서, 기능적 단편은 그가 유래된 조작된 DNA 중합효소 폴리펩티드(즉, 모 조작된 DNA 중합효소)의 활성의 적어도 약 95%, 96%, 97%, 98%, 또는 99%를 포함한다. 일부 실시 양태에서, 기능적 단편은 조작된 DNA 중합효소의 모 서열의 적어도 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 또는 99%를 포함한다. 일부 실시 양태에서 기능적 단편은 5개 미만, 10개 미만, 15개 미만, 10개 미만, 25개 미만, 30개 미만, 35개 미만, 40개 미만, 45개 미만, 50개 미만, 55개 미만, 60개 미만, 65개 미만, 또는 70개 미만의 아미노산만큼 절두될 것이다.
일부 실시 양태에서, 적어도 하나의 개선된 특성을 나타내는 조작된 DNA 중합효소 폴리펩티드는 서열번호 2, 6, 22, 24, 26, 28 및/또는 824와 적어도 85%, 적어도 88%, 적어도 90%, 적어도 91%, 적어도 92%, 적어도 93%, 적어도 94%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 적어도 99% 이상의 아미노산 서열 동일성, 및 서열번호 2, 6, 22, 24, 26, 28 및/또는 824와 비교하여 하나 이상의 아미노산 위치(예컨대 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15개 이상의 위치)에서 아미노산 잔기 차이를 갖는다. 일부 실시 양태에서, 조작된 DNA 중합효소는 서열번호 2, 6, 22, 24, 26, 28 및/또는 824와 적어도 90%의 서열 동일성을 포함하고, 적어도 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개 이상의 아미노산 위치의 아미노산 차이를 포함한다. 일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드는 서열번호 6, 22, 24, 26, 28 및/또는 824의 서열로 이루어진다.
조작된 폴리펩티드를 코딩하는 폴리뉴클레오티드, 발현 벡터 및 숙주 세포 :
본 발명은 본원에 기재된 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 제공한다. 일부 실시 양태에서, 폴리뉴클레오티드는 폴리펩티드를 발현할 수 있는 재조합 폴리뉴클레오티드를 생성하기 위해 유전자 발현을 제어하는 하나 이상의 이종의 조절 서열에 작동 가능하게 연결된다. 일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드(들)를 코딩하는 적어도 하나의 이종의 폴리뉴클레오티드를 함유하는 발현 구축물은 상응하는 DNA 중합효소 폴리펩티드(들)를 발현하기 위해 적절한 숙주 세포 내로 도입된다.
당업자에게 명백한 바와 같이, 단백질 서열의 가용성 및 다양한 아미노산에 상응하는 코돈에 대한 지식은 대상 폴리펩티드를 코딩할 수 있는 모든 폴리뉴클레오티드에 대한 설명을 제공한다. 동일한 아미노산이 대체 또는 동의 코돈에 의해 코딩되는 유전자 코드의 축퇴로 매우 많은 수의 핵산이 만들어질 수 있으며, 이들 모두는 조작된 DNA 중합효소 폴리펩티드를 코딩한다. 따라서, 본 발명은 가능한 코돈 선택에 기초한 조합을 선택함으로써 본원에 기재된 DNA 중합효소 폴리펩티드를 코딩하는 만들어질 수 있는 DNA 중합효소 폴리뉴클레오티드의 각각의 모든 가능한 변이의 생산을 위한 방법 및 조성물을 제공하며, 이러한 모든 변이는 실시예(예를 들어, 표 3.1, 3.2, 3.3. 3.4, 3.5, 3.6, 3.7, 3.8, 4.1, 4.2, 4.3, 4.4, 및/또는 4.5)에 제시된 아미노산 서열을 포함하여 본원에 기재된 임의의 폴리펩티드에 대해 구체적으로 개시된 것으로 간주되어야 한다.
일부 실시 양태에서, 코돈은 바람직하게는, 단백질 생산을 위해 선택된 숙주 세포에 의한 이용을 위해 최적화된다. 예를 들어, 박테리아에서 사용되는 바람직한 코돈은 전형적으로 박테리아에서의 발현에 사용된다. 결과적으로, 조작된 DNA 중합효소 폴리펩티드를 코딩하는 코돈 최적화된 폴리뉴클레오티드는 전장의 코딩 영역에서 코돈 위치의 약 40%, 50%, 60%, 70%, 80%, 90% 또는 90% 이상에서 바람직한 코돈을 포함한다.
일부 실시 양태에서, DNA 중합효소 폴리뉴클레오티드는 본원에 개시된 특성을 갖는 DNA 중합효소 활성을 갖는 조작된 폴리펩티드를 코딩하며, 여기서 폴리펩티드는 서열번호 2, 6, 22, 24, 26, 28 및/또는 824로부터 선택된 참조 서열과 적어도 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 동일성을 갖는 아미노산 서열, 또는 임의의 변이체(예를 들어, 실시예에 제공된 것)의 아미노산 서열, 및 서열번호 2, 6, 22, 24, 26, 28 및/또는 824의 참조 폴리뉴클레오티드, 또는 실시예에 개시된 바와 같은 임의의 변이체의 아미노산 서열과 비교하여 하나 이상의 잔기 차이(예를 들어, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개 이상의 아미노산 잔기 위치)를 포함한다. 일부 실시 양태에서, 참조 서열은 서열번호 2, 6, 22, 24, 26, 28 및/또는 824로부터 선택된다. 일부 실시 양태에서, 조작된 DNA 중합효소 변이체는 서열번호 6, 22, 24, 26, 28 및/또는 824에 제시된 폴리펩티드 서열을 포함한다. 일부 실시 양태에서, 조작된 DNA 중합효소 변이체는 실시예에 제공된 변이 DNA 중합효소의 치환(들) 또는 치환 세트(들)를 포함한다.
본 발명은 본원에 제공된 조작된 DNA 중합효소 변이체를 코딩하는 폴리뉴클레오티드를 제공한다. 일부 실시 양태에서, 폴리뉴클레오티드는 서열번호 1, 5, 21, 23, 25, 27 및/또는 823으로부터 선택된 참조 서열과 적어도 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 동일성을 갖는 뉴클레오티드 서열, 또는 임의의 변이체(예를 들어, 실시예에 제공된 것)의 핵산 서열, 및 서열번호 1, 5, 21, 23, 25, 27 및/또는 823의 참조 폴리뉴클레오티드, 또는 실시예에 개시된 바와 같은 임의의 변이체의 핵산 서열과 비교하여 하나 이상의 잔기 차이(예를 들어, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개 이상의 위치)를 포함한다. 일부 실시 양태에서, 참조 서열은 서열번호 1, 5, 21, 23, 25, 27 및/또는 823으로부터 선택된다. 일부 실시 양태에서, 폴리뉴클레오티드는 매우 엄격한 조건하에서 서열번호 1, 5, 21, 23, 25, 27 및/또는 823으로부터 선택된 참조 폴리뉴클레오티드 서열, 또는 이의 상보체, 또는 본원에 제공된 임의의 변이 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드 서열에 혼성화할 수 있다. 일부 실시 양태에서, 매우 엄격한 조건 하에서 혼성화할 수 있는 폴리뉴클레오티드는 서열번호 2, 22, 24, 26, 28 및/또는 824와 비교하여 하나 이상의 잔기 차이를 갖는 아미노산 서열을 포함하는 DNA 중합효소 폴리펩티드를 코딩한다. 일부 실시 양태에서, 조작된 DNA 중합효소 변이체는 서열번호 1, 5, 21, 23, 25, 27 및/또는 823에 제시된 폴리뉴클레오티드 서열에 의해 코딩된다.
일부 실시 양태에서, 본원의 임의의 조작된 DNA 중합효소 폴리펩티드를 코딩하는 단리된 폴리뉴클레오티드는 DNA 중합효소 폴리펩티드의 발현을 촉진하기 위해 다양한 방식으로 조작된다. 일부 실시 양태에서, DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드는 DNA 중합효소 폴리뉴클레오티드 및/또는 폴리펩티드의 발현을 조절하기 위해 하나 이상의 제어 서열이 존재하는 발현 벡터를 포함한다. 사용되는 발현 벡터에 따라 벡터에 삽입하기 전에 단리된 폴리뉴클레오티드의 조작이 바람직하거나 필요할 수 있다. 재조합 DNA 방법을 이용하여 폴리뉴클레오티드 및 핵산 서열을 변형하는 기술은 당 업계에 잘 알려져 있다. 일부 실시 양태에서, 제어 서열은 특히 프로모터, 리더 서열, 폴리아데닐화 서열, 프로펩티드 서열, 신호 펩티드 서열, 및 전사 종결자를 포함한다. 일부 실시 양태에서, 적합한 프로모터는 숙주 세포 선택에 기초하여 선택된다. 박테리아 숙주 세포의 경우, 본 개시 내용의 핵산 구축물의 전사를 지시하기 위해 적합한 프로모터는 이. 콜라이 lac 오페론, 스트렙토마이세스 씰리칼라(Streptomyces coelicolor) 아가라아제 유전자(dagA), 바실러스 서브틸리스(Bacillus subtilis) 레반수크라아제 유전자(sacB), 바실러스 리체니포르미스(Bacillus licheniformis) 알파-아밀라아제 유전자(amyL), 바실러스 스테아로테르모필루스(Bacillus stearothermophilus) 말토제닉(maltogenic) 아밀라아제 유전자(amyM), 바실러스 아밀로리퀘파시엔스(Bacillus amyloliquefaciens) 알파-아밀라아제 유전자(amyQ), 바실러스 리체니포르미스 페니실리나제 유전자(penP), 바실러스 서브틸리스 xylA 및 xylB 유전자, 및 원핵생물 베타-락타마제 유전자(예를 들어, Villa-Kamaroff et al., Proc. Natl. Acad. Sci. USA 75: 3727-3731 [1978] 참조)로부터 수득된 프로모터, 뿐만 아니라 tac 프로모터(예를 들어, DeBoer et al., Proc. Natl. Acad. Sci. USA 80: 21-25 [1983] 참조)를 포함하지만 이에 제한되지는 않는다. 사상 진균 숙주 세포를 위한 예시적인 프로모터는 아스페르길루스 오리제(Aspergillus oryzae) TAKA 아밀라아제, 리조무코르 미에헤이(Rhizomucor miehei) 아스파르트산 프로테이나아제, 아스페르길루스 니제르(Aspergillus niger) 중성 알파-아밀라아제, 아스페르길루스 니제르 산 안정성 알파-아밀라아제, 아스페르길루스 니제르 또는 아스페르길루스 아와모리(Aspergillus awamori) 글루코아밀라아제(glaA), 리조무코르 미에헤이 리파아제, 아스페르길루스 오리제 알칼리성 프로테아제, 아스페르길루스 오리제 트리오스 포스페이트 이소머라아제, 아스페르길루스 니둘란스(Aspergillus nidulans) 아세트아미다제, 및 푸사리움 옥시스포룸(Fusarium oxysporum) 트립신 유사 프로테아제(예를 들어, WO 96/00787 참조)에 대한 유전자로부터 수득된 프로모터, 뿐만 아니라 NA2-tpi 프로모터(아스페르길루스 니제르 중성 알파-아밀라아제와 아스페르길루스 오리제 트리오스 포스페이트 이소머라아제의 유전자로부터의 프로모터 혼성체), 및 이들의 돌연변이, 절두, 및 혼성 프로모터를 포함하지만 이에 제한되지는 않는다. 예시적인 효모 세포 프로모터는 사카로마이세스 세레비지에(Saccharomyces cerevisiae) 에놀라아제(ENO-1), 사카로마이세스 세레비지에 갈락토키나아제(GAL1), 사카로마이세스 세레비지에 알코올 데히드로게나아제/글리세르알데히드-3-포스페이트 데히드로게나아제(ADH2/GAP), 및 사카로마이세스. 세레비지에 3-포스포글리세레이트 키나아제에 대한 유전자로부터 유래할 수 있다. 효모 숙주 세포에 대한 다른 유용한 프로모터는 당 업계에 공지되어 있다(예를 들어, Romanos et al., Yeast 8: 423-488 [1992] 참조).
일부 실시 양태에서, 제어 서열은 또한 적합한 전사 종결자 서열(즉, 전사를 종결하기 위해 숙주 세포에 의해 인식되는 서열)이다. 일부 실시 양태에서, 종결자 서열은 DNA 중합효소 폴리펩티드를 코딩하는 핵산 서열의 3 '말단에 작동 가능하게 연결된다. 선택된 숙주 세포에서 기능을 하는 임의의 적합한 종결자가 본 발명에서 사용된다. 사상 진균 숙주 세포에 대한 예시적인 전사 종결자는 아스페르길루스 오리제 TAKA 아밀라아제, 아스페르길루스 니제르 글루코아밀라아제, 아스페르길루스 니둘란스 안트라닐레이트 신타아제, 아스페르길루스 니제르 알파-글루코시다아제, 및 푸사리움 옥시스포룸 트립신 유사 프로테아제에 대한 유전자로부터 수득될 수 있다. 효모 숙주 세포에 대한 예시적인 종결자는 사카로마이세스 세레비지에 에놀라아제, 사카로마이세스 세레비지에 시토크롬 C(CYCl), 및 사카로마이세스 세레비지에 글리세르알데히드-3-포스페이트 데히드로게나아제에 대한 유전자로부터 수득될 수 있다. 효모 숙주 세포에 대한 다른 유용한 종결자는 당업자에게 공지되어 있다(예를 들어, Romanos et al., 상기 참조).
일부 실시 양태에서, 제어 서열은 또한 적합한 리더 서열(즉, 숙주 세포에 의한 번역에 중요한 mRNA의 비번역 영역)이다. 일부 실시 양태에서, 리더 서열은 DNA 중합효소 폴리펩티드를 코딩하는 핵산 서열의 5' 말단에 작동 가능하게 연결된다. 선택된 숙주 세포에서 기능을 하는 임의의 적합한 리더 서열이 본 발명에 사용된다. 사상 진균 숙주 세포를 위한 예시적인 리더는 아스페르길루스 오리제 TAKA 아밀라아제, 및 아스페르길루스 니둘란스 트리오스 포스페이트 이소머라아제에 대한 유전자로부터 수득된다. 효모 숙주 세포에 적합한 리더는 사카로마이세스 세레비지에 에놀라아제(ENO-1), 사카로마이세스 세레비지에 3-포스포글리세레이트 키나아제, 사카로마이세스 세레비지에 알파-인자, 및 사카로마이세스 세레비지에 알코올 데히드로게나아제/글리세르알데히드-3-포스페이트 데히드로게나아제(ADH2/GAP)에 대한 유전자로부터 수득된다.
일부 실시 양태에서, 제어 서열은 또한 폴리아데닐화 서열(즉, 핵산 서열의 3' 말단에 작동 가능하게 연결된 서열로, 전사될 때 전사된 mRNA에 폴리아데노신 잔기를 첨가하는 신호로서 숙주 세포에 의해 인식됨)이다. 선택된 숙주 세포에서 기능을 하는 임의의 적합한 폴리아데닐화 서열이 본 발명에 사용된다. 사상 진균 숙주 세포에 대한 예시적인 폴리아데닐화 서열은 아스페르길루스 오리제 TAKA 아밀라아제, 아스페르길루스 니제르 글루코아밀라아제, 아스페르길루스 니둘란스 안트라닐레이트 신타아제, 푸사리움 옥시스포룸 트립신 유사 프로테아제, 및 아스페르길루스 니제르 알파-글루코시다아제에 대한 유전자를 포함하지만 이에 제한되지는 않는다. 효모 숙주 세포에 유용한 폴리아데닐화 서열은 공지되어 있다(예를 들어, Guo and Sherman, Mol. Cell. Biol., l5: 5983-5990 [1995] 참조).
일부 실시 양태에서, 제어 서열은 또한 신호 펩티드(즉, 폴리펩티드의 아미노 말단에 연결된 아미노산 서열을 코딩하고 코딩된 폴리펩티드를 세포의 분비 경로로 유도하는 코딩 영역)이다. 일부 실시 양태에서, 핵산 서열의 코딩 서열의 5' 말단은 분비되는 폴리펩티드를 코딩하는 코딩 영역의 세그먼트와 번역 판독 프레임으로 본래 연결된 신호 펩티드 코딩 영역을 내재적으로 포함한다. 대안적으로, 일부 실시 양태에서, 코딩 서열의 5' 말단은 코딩 서열에 외래인 신호 펩티드 코딩 영역을 포함한다. 발현된 폴리펩티드를 선택된 숙주 세포의 분비 경로로 유도하는 임의의 적합한 신호 펩티드 코딩 영역이 조작된 폴리펩티드(들)의 발현에 사용된다. 박테리아 숙주 세포에 대해 효과적인 신호 펩티드 코딩 영역은 바실러스 NClB 11837 말토제닉 아밀라아제, 바실러스 스테아로테르모필루스 알파-아밀라아제, 바실러스 리체니포르미스 서브틸리신, 바실루스 리체니포르미스 베타-락타마제, 바실러스 스테아로테르모필루스 중성 프로테아제(nprT, nprS, nprM), 및 바실러스 서브틸리스 prsA에 대한 유전자로부터 수득된 것들을 포함하지만 이에 제한되지는 않는다. 추가 신호 펩티드는 당 업계에 공지되어 있다(예를 들어, Simonen and Palva, Microbiol. Rev., 57: 109-137 [1993] 참조). 일부 실시 양태에서, 사상 진균 숙주 세포에 효과적인 신호 펩티드 코딩 영역은 아스페르길루스 오리제 TAKA 아밀라아제, 아스페르길루스 니제르 중성 아밀라아제, 아스페르길루스 니제르 글루코아밀라아제, 리조무코르 미에헤이 아스파르트산 프로테이나아제, 휴미콜라 인솔렌스(Humicola insolens) 셀룰라아제, 및 휴미콜라 라누지노사(Humicola lanuginosa) 리파아제에 대한 유전자로부터 수득된 신호 펩티드 코딩 영역을 포함하지만 이에 제한되지는 않는다. 효모 숙주 세포에 유용한 신호 펩티드는 사카로마이세스 세레비지에 알파-인자 및 사카로마이세스 세레비지에 인버타제에 대한 유전자로부터 유래된 것들을 포함하지만 이에 제한되지는 않는다.
일부 실시 양태에서, 제어 서열은 또한 폴리펩티드의 아미노 말단에 위치하는 아미노산 서열을 코딩하는 프로펩티드 코딩 영역이다. 그 결과 생성된 폴리펩티드는 "전효소(proenzyme)" 또는 "프로폴리펩티드" 또는 "자이모젠"으로 지칭된다. 프로폴리펩티드는 프로폴리펩티드로부터 프로펩티드의 촉매적 또는 자가 촉매적 절단에 의해 성숙한 활성의 폴리펩티드로 전환될 수 있다. 프로펩티드 코딩 영역은 바실러스 서브틸리스 알칼리성 프로테아제(aprE), 바실러스 서브틸리스 중성 프로테아제(nprT), 사카로마이세스 세레비지에 알파-인자, 리조무코르 미에헤이 아스파르트산 프로테이나아제, 및 마이셀리오프토라 테르모필라(Myceliophthora thermophila) 락타아제에 대한 유전자를 포함하지만 이에 제한되지 않는 임의의 적합한 공급원으로부터 수득할 수 있다(예를 들어, WO 95/33836 참조). 신호 펩티드 및 프로펩티드 영역이 모두 폴리펩티드의 아미노 말단에 존재하는 경우, 프로펩티드 영역은 폴리펩티드의 아미노 말단 옆에 위치하고 신호 펩티드 영역은 프로펩티드 영역의 아미노 말단 옆에 위치한다.
일부 실시 양태에서, 조절 서열이 또한 사용된다. 이들 서열은 숙주 세포의 성장에 비해 폴리펩티드의 발현의 조절을 용이하게 한다. 조절 시스템의 예는 조절 화합물의 존재를 포함하여 화학적 또는 물리적 자극에 반응하여 유전자의 발현을 켜거나 끄는 것들이다. 원핵 숙주 세포에서, 적합한 조절 서열은 lac, tac, 및 trp 오퍼레이터 시스템을 포함하지만 이에 제한되지는 않는다. 효모 숙주 세포에서, 적합한 조절 시스템은 ADH2 시스템 또는 GAL1 시스템을 포함하지만 이에 제한되지는 않는다. 사상 진균에서, 적합한 조절 서열은 TAKA 알파-아밀라아제 프로모터, 아스페르길루스 니제르 글루코아밀라아제 프로모터, 및 아스페르길루스 오리제 글루코아밀라아제 프로모터를 포함하지만 이에 제한되지는 않는다.
또 다른 측면에서, 본 발명은 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드, 및 이들이 도입될 숙주의 유형에 따라 프로모터 및 종결자, 복제 기점 등과 같은 하나 이상의 발현 조절 영역을 포함하는 재조합 발현 벡터에 관한 것이다. 일부 실시 양태에서, 본원에 기재된 다양한 핵산 및 제어 서열은 함께 연결되어 하나 이상의 편리한 제한 부위를 포함하여 이러한 부위에서 DNA 중합효소 폴리펩티드를 코딩하는 핵산 서열의 삽입 또는 치환을 허용하는 재조합 발현 벡터를 생성한다. 대안적으로, 일부 실시 양태에서, 본 발명의 핵산 서열은 핵산 서열 또는 서열을 포함하는 핵산 구축물을 발현을 위한 적절한 벡터에 삽입함으로써 발현된다. 발현 벡터의 생성을 포함하는 일부 실시 양태에서, 코딩 서열은 발현을 위한 적절한 제어 서열과 작동 가능하게 연결되도록 벡터에 위치된다.
재조합 발현 벡터는 재조합 DNA 절차에 편리하게 적용되고 DNA 중합효소 폴리뉴클레오티드 서열의 발현을 유발할 수 있는 임의의 적합한 벡터(예를 들어, 플라스미드 또는 바이러스)일 수 있다. 벡터의 선택은 전형적으로 벡터가 도입될 숙주 세포와 벡터의 적합성에 따라 달라진다. 벡터는 선형 또는 폐쇄된 원형 플라스미드일 수 있다.
일부 실시 양태에서, 발현 벡터는 자율 복제 벡터(즉, 그 복제가 염색체 복제와 독립적인 염색체 외 독립체로서 존재하는 벡터, 예컨대 플라스미드, 염색체 외 요소, 미니 염색체, 또는 인공 염색체)이다. 벡터는 자가 복제를 보장하기 위한 임의의 수단을 포함한다. 일부 대안적인 실시 양태에서, 벡터는 숙주 세포에 도입될 때, 벡터는 게놈에 통합되고 그가 통합된 염색체(들)와 함께 복제되는 것이다. 또한, 일부 실시 양태에서, 숙주 세포의 게놈으로 도입될 전체 DNA, 및/또는 트랜스포존을 함께 포함하는 단일 벡터 또는 플라스미드, 또는 둘 이상의 벡터 또는 플라스미드가 사용된다.
일부 실시 양태에서, 발현 벡터는 형질전환된 세포의 용이한 선별을 허용하는 하나 이상의 선별 가능 마커를 함유한다. "선별 가능 마커"는 그 생성물이 살생물제 또는 바이러스 내성, 중금속에 대한 내성, 영양 요구성에 대한 원형 영양성 등을 제공하는 유전자이다. 박테리아 선별 가능 마커의 예는 바실러스 서브틸리스 또는 바실러스 리체니포르미스로부터의 dal 유전자, 또는 암피실린, 카나마이신, 클로람페니콜, 또는 테트라사이클린 내성과 같은 항생제 내성을 부여하는 마커를 포함하지만 이에 제한되지는 않는다. 효모 숙주 세포에 적합한 마커는 ADE2, HIS3, LEU2, LYS2, MET3, TRP1, 및 URA3을 포함하지만 이에 제한되지는 않는다. 사상 진균 숙주 세포에서 사용하기에 적합한 임의의 선별 가능 마커는 amdS(아세트아미다제: 예를 들어 에이. 니둘란스 도는 에이. 오리제 유래), argB(오르니틴 카르바모일트랜스퍼라아제), bar(포스피노트리신 아세틸트랜스퍼라아제; 예를 들어, 에스. 히그로스코피쿠스 유래), hph(히그로마이신 포스포트랜스퍼라아제), niaD(질산 환원효소), pyrG(오로티딘-5'-포스페이트 디카르복실라아제, 예를 들어, 에이 니둘란스 또는 에이. 오리제 유래), sC(설페이트 아데닐트랜스퍼라아제), 및 trpC(안트라닐레이트 신타아제), 및 이들의 등가물을 포함하지만 이에 제한되지는 않는다. 또 다른 측면에서, 본 발명은 본 발명의 적어도 하나의 조작된 DNA 중합효소 폴리펩티드를 코딩하는 적어도 하나의 폴리뉴클레오티드를 포함하는 숙주 세포로서, 폴리뉴클레오티드(들)는 숙주 세포에서 조작된 DNA 중합효소의 발현을 위해 하나 이상의 제어 서열에 작동 가능하게 연결된 것인 숙주 세포를 제공한다. 본 발명의 발현 벡터에 의해 코딩되는 폴리펩티드를 발현하는 데 사용하기에 적합한 숙주 세포는 당 업계에 잘 알려져 있으며, 이. 콜라이, 비브리오 플루비알리스(Vibrio fluvialis), 스트렙토마이세스 및 살모넬라 티피무륨(Salmonella typhimurium)과 같은 박테리아 세포; 효모 세포(예를 들어, 사카로마이세스 세레비지에 또는 피키아 파스토리스(ATCC 수탁 번호 201178)와 같은 진균 세포; 드로소필라(Drosophila) S2 및 스포돕테라(Spodoptera) Sf9 세포와 같은 곤충 세포; CHO, COS, BHK, 293, 및 Bowes 흑색종 세포와 같은 동물 세포; 및 식물 세포를 포함하지만 이에 제한되지는 않는다. 예시적인 숙주 세포는 또한 다양한 에쉐리키아 콜라이(Escherichia coli) 균주(예를 들어, W3110(△fhuA) 및 BL21)를 포함한다.
따라서, 또 다른 측면에서, 본 발명은 조작된 DNA 중합효소 폴리펩티드를 생산하는 방법으로서, 방법은 폴리펩티드의 발현에 적합한 조건하에서 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 발현할 수 있는 숙주 세포를 배양하는 단계를 포함하는 방법을 포함한다. 일부 실시 양태에서, 방법은 본원에 기재된 바와 같이 DNA 중합효소 폴리펩티드를 단리 및/또는 정제하는 단계를 추가로 포함한다.
숙주 세포에 대한 적절한 배양 배지 및 성장 조건은 당 업계에 잘 알려져 있다. DNA 중합효소 폴리펩티드의 발현을 위한 폴리뉴클레오티드를 세포 내로 도입하는 임의의 적합한 방법이 본 발명에서 사용될 것으로 생각된다. 적합한 기술은 전기 천공, 바이올리스틱(biolistic) 입자 충격, 리포솜 매개 형질 감염, 염화칼슘 형질 감염, 및 원형질체 융합을 포함하지만 이에 제한되지 않는다.
본원에 개시된 특성을 갖는 조작된 DNA 중합효소 폴리펩티드는 자연 발생 또는 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 당 업계에 공지된 및/또는 본원에 기재된 임의의 적합한 돌연변이 유발 및/또는 유도 진화 방법에 적용함으로써 수득될 수 있다. 예시적인 유도 진화 기술은 돌연변이 유발 및/또는 DNA 셔플링(예를 들어, Stemmer, Proc. Natl. Acad. Sci. USA 91:10747-10751 [1994]; WO 95/22625; WO 97/0078; WO 97/35966; WO 98/27230; WO 00/42651; WO 01/75767 및 미국 특허 제6,537,746호 참조)이다. 사용될 수 있는 다른 유도 진화 절차는 특히 StEP(staggered extension process), 시험관 내 재조합(예를 들어, Zhao et al., Nat. Biotechnol., 16:258-261 [1998] 참조), 돌연변이 유발 PCR(예를 들어, Caldwell et al., PCR Methods Appl., 3:S136-S140 [1994] 참조), 및 카세트 돌연변이 유발(예를 들어, Black et al., Proc. Natl. Acad. Sci. USA 93:3525-3529 [1996] 참조)을 포함한다.
돌연변이 유발 및 유도 진화 방법은 발현, 스크리닝 및 분석될 수 있는 변이체 라이브러리를 생성하기 위해 DNA 중합효소 코딩 폴리뉴클레오티드에 쉽게 적용될 수 있다. 임의의 적합한 돌연변이 유발 및 유도 진화 방법이 본 발명에서 사용되며 당 업계에 잘 알려져 있다(예를 들어, 미국 특허 제5,605,793호, 제5,811,238호, 제5,830,721호, 제5,834,252호, 제5,837,458호, 제5,928,905호, 제6,096,548호, 제6,117,679호, 제6,132,970호, 제6,165,793호, 제6,180,406호, 제6,251,674호, 제6,265,201호, 제6,277,638호, 제6,287,861호, 제6,287,862호, 제6,291,242호, 제6,297,053호, 제6,303,344호, 제6,309,883호, 제6,319,713호, 제6,319,714호, 제6,323,030호, 제6,326,204호, 제6,335,160호, 제6,335,198호, 제6,344,356호, 제6,352,859호, 제6,355,484호, 제6,358,740호, 제6,358,742호, 제6,365,377호, 제6,365,408호, 제6,368,861호, 제6,372,497호, 제6,337,186호, 제6,376,246호, 제6,379,964호, 제6,387,702호, 제6,391,552호, 제6,391,640호, 제6,395,547호, 제6,406,855호, 제6,406,910호, 제6,413,745호, 제6,413,774호, 제6,420,175호, 제6,423,542호, 제6,426,224호, 제6,436,675호, 제6,444,468호, 제6,455,253호, 제6,479,652호, 제6,482,647호, 제6,483,011호, 제6,484,105호, 제6,489,146호, 제6,500,617호, 제6,500,639호, 제6,506,602호, 제6,506,603호, 제6,518,065호, 제6,519,065호, 제6,521,453호, 제6,528,311호, 제6,537,746호, 제6,573,098호, 제6,576,467호, 제6,579,678호, 제6,586,182호, 제6,602,986호, 제6,605,430호, 제6,613,514호, 제6,653,072호, 제6,686,515호, 제6,703,240호, 제6,716,631호, 제6,825,001호, 제6,902,922호, 제6,917,882호, 제6,946,296호, 제6,961,664호, 제6,995,017호, 제7,024,312호, 제7,058,515호, 제7,105,297호, 제7,148,054호, 제7,220,566호, 제7,288,375호, 제7,384,387호, 제7,421,347호, 제7,430,477호, 제7,462,469호, 제7,534,564호, 제7,620,500호, 제7,620,502호, 제7,629,170호, 제7,702,464호, 제7,747,391호, 제7,747,393호, 제7,751,986호, 제7,776,598호, 제7,783,428호, 제7,795,030호, 제7,853,410호, 제7,868,138호, 제7,783,428호, 제7,873,477호, 제7,873,499호, 제7,904,249호, 제7,957,912호, 제7,981,614호, 제8,014,961호, 제8,029,988호, 제8,048,674호, 제8,058,001호, 제8,076,138호, 제8,108,150호, 제8,170,806호, 제8,224,580호, 제8,377,681호, 제8,383,346호, 제8,457,903호, 제8,504,498호, 제8,589,085호, 제8,762,066호, 제8, 768,871호, 제9,593,326호, 제9,665,694호, 제9,684,771호, 및 관련된 모든 PCT 및 US 이외의 대응 특허; Ling et al., Anal. Biochem., 254(2):157-78 [1997]; Dale et al., Meth. Mol. Biol., 57:369-74 [1996]; Smith, Ann. Rev. Genet., 19:423-462 [1985]; Botstein et al., Science, 229:1193-1201 [1985]; Carter, Biochem. J., 237:1-7 [1986]; Kramer et al., Cell, 38:879-887 [1984]; Wells et al., Gene, 34:315-323 [1985]; Minshull et al., Curr. Op. Chem. Biol., 3:284-290 [1999]; Christians et al., Nat. Biotechnol., 17:259-264 [1999]; Crameri et al., Nature, 391:288-291 [1998]; Crameri, et al., Nat. Biotechnol., 15:436-438 [1997]; Zhang et al., Proc. Nat. Acad. Sci. U.S.A., 94:4504-4509 [1997]; Crameri et al., Nat. Biotechnol., 14:315-319 [1996]; Stemmer, Nature, 370:389-391 [1994]; Stemmer, Proc. Nat. Acad. Sci. USA, 91:10747-10751 [1994]; EP 3 049 973; WO 95/22625; WO 97/0078; WO 97/35966; WO 98/27230; WO 00/42651; WO 01/75767; WO 2009/152336; 및 WO 2015/048573을 참조하며, 이들 모두는 본원에 참고로 포함됨).
일부 실시 양태에서, 돌연변이 유발 처리 후에 수득된 효소 클론은 효소 제제를 규정된 온도(또는 다른 분석 조건)에 적용하고 열처리 또는 다른 적합한 분석 조건 후에 남아있는 효소 활성의 양을 측정함으로써 스크리닝된다. 그런 후 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 포함하는 클론은 유전자로부터 단리되고, 뉴클레오티드 서열 변화(있는 경우)를 확인하기 위해 시퀀싱되고, 숙주 세포에서 효소를 발현하는 데 사용된다. 발현 라이브러리로부터 효소 활성을 측정하는 단계는 당 업계에 공지된 임의의 적합한 방법(예를 들어, HPLC 분석과 같은 표준 생화학 기술)을 사용하여 수행될 수 있다.
공지된 서열의 조작된 폴리펩티드의 경우, 효소를 코딩하는 폴리뉴클레오티드는 공지된 합성 방법에 따라 표준 고상 방법에 의해 제조될 수 있다. 일부 실시 양태에서, 약 100개 이하의 염기의 단편을 개별적으로 합성한 후, (예를 들어, 효소적 또는 화학적 결찰 방법, 또는 중합효소 매개 방법에 의해) 연결하여 임의의 원하는 연속 서열을 형성할 수 있다. 예를 들어, 본원에 개시된 폴리뉴클레오티드 및 올리고뉴클레오티드는 자동화 합성 방법에서 전형적으로 실시되는 바와 같이 고전적인 포스포라미다이트 방법(예를 들어, Beaucage et al., Tet. Lett., 22:1859-69 [1981]; 및 Matthes et al., EMBO J., 3:801-05 [1984] 참조)을 이용한 화학 합성에 의해 제조될 수 있다. 포스포라미다이트 방법에 따라 올리고뉴클레오티드가 합성된다(예를 들어, 자동 DNA 합성기에서 정제, 어닐링, 결찰되고 적절한 벡터로 클로닝됨).
따라서, 일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드를 제조하는 방법은 (a) 본원에 기재된 임의의 변이체의 아미노산 서열로부터 선택된 아미노산 서열을 포함하는 폴리펩티드를 코딩하는 폴리뉴클레오티드를 합성하는 단계, 및 (b) 폴리뉴클레오티드에 의해 코딩된 DNA 중합효소 폴리펩티드를 발현하는 단계를 포함할 수 있다. 방법의 일부 실시 양태에서, 폴리뉴클레오티드에 의해 코딩된 아미노산 서열은 경우에 따라 하나 또는 여러 개(예를 들어, 최대 3, 4, 5개, 또는 최대 10개)의 아미노산 잔기 결실, 삽입 및/또는 치환을 가질 수 있다. 일부 실시 양태에서, 아미노산 서열은 경우에 따라 1-2, 1-3, 1-4, 1-5, 1-6, 1-7, 1-8, 1-9, 1-10, 1-15, 1-20, 1-21, 1-22, 1-23, 1-24, 1-25, 1-30, 1-35, 1-40, 1-45, 또는 1-50개의 아미노산 잔기 결실, 삽입 및/또는 치환을 갖는다. 일부 실시 양태에서, 아미노산 서열은 경우에 따라 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, 또는 50개의 아미노산 잔기 결실, 삽입 및/또는 치환을 갖는다. 일부 실시 양태에서, 아미노산 서열은 경우에 따라 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 20, 21, 22, 23, 24, 또는 25개의 아미노산 잔기 결실, 삽입 및/또는 치환을 갖는다. 일부 실시 양태에서, 치환은 보존적 또는 비-보존적 치환이다.
발현된 조작된 DNA 중합효소 폴리펩티드는 본원에 기재된 분석 및 조건을 포함하지만 이에 제한되지 않는 당 업계에 공지된 임의의 적합한 분석을 사용하여 임의의 원하는 개선된 특성 또는 특성의 조합(예를 들어, 활성, 선택성, 충실도, 안정성, 열안정성, 다양한 pH 수준에 대한 내성, 프로테아제 민감성 등)에 대해 평가될 수 있다.
일부 실시 양태에서, 숙주 세포에서 발현된 임의의 조작된 DNA 중합효소 폴리펩티드는 특히, 리소자임 처리, 초음파 처리, 여과, 염석, 초 원심분리, 및 크로마토그래피를 포함하는 단백질 정제를 위한 임의의 하나 이상의 잘 알려진 기술을 사용하여 세포 및/또는 배양 배지로부터 회수된다.
DNA 중합효소 폴리펩티드의 단리를 위한 크로마토그래피 기술은 특히 역상 크로마토그래피, 고성능 액체 크로마토그래피, 이온 교환 크로마토그래피, 소수성 상호 작용 크로마토그래피, 크기 배제 크로마토그래피, 겔 전기영동, 및 친화성 크로마토그래피를 포함한다. 특정 효소를 정제하기 위한 조건은 부분적으로 순 전하, 소수성, 친수성, 분자량, 분자 모양 등과 같은 인자에 따라 다르며, 당업자에게는 명백할 것이다. 일부 실시 양태에서, 친화성 기술을 사용하여 개선된 DNA 중합효소 를 단리할 수 있다. 친화성 크로마토그래피 정제를 위해, 관심의 DNA 중합효소 폴리펩티드에 특이적으로 결합하는 임의의 항체가 사용될 수 있다. 항체 생산을 위해, 토끼, 마우스, 래트 등을 포함하지만 이에 제한되지 않는 다양한 숙주 동물은 DNA 중합효소 폴리펩티드, 또는 이의 단편을 주사하여 면역화된다. 일부 실시 양태에서, DNA 중합효소 폴리펩티드 또는 단편은 측쇄 작용기 또는 측쇄 작용기에 부착된 링커에 의해 BSA와 같은 적합한 담체에 부착된다.
일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드는 조작된 DNA 중합효소 폴리펩티드의 생산에 도움이 되는 조건하에 본원에 기재된 바와 같은 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드 서열을 포함하는 숙주 세포(예를 들어, 이. 콜라이 균주)를 배양하는 단계 및 세포 및/또는 배양 배지로부터 조작된 DNA 중합효소 폴리펩티드를 회수하는 단계를 포함하는 방법에 의해 숙주 세포에서 생산된다. 일부 실시 양태에서, 숙주 세포는 하나 초과의 조작된 DNA 중합효소 폴리펩티드를 생산한다.
일부 실시 양태에서, 본 발명은 조작된 DNA 중합효소 폴리펩티드를 생산하는 방법으로서, 조작된 DNA 중합효소 폴리펩티드의 생산을 허용하는 적합한 배양 조건하에서 참조 서열 서열번호 2, 6, 24, 26, 28 및/또는 824와 적어도 85%, 90%, 95%, 96%, 97%, 98%, 또는 99% 서열 동일성, 및 하나 이상의 아미노산 잔기를 갖는 조작된 DNA 중합효소 폴리펩티드를 코딩하는 폴리뉴클레오티드를 포함하는 재조합 박테리아 세포를 배양하는 단계, 및 경우에 따라 배양물 및/또는 배양된 박테리아 세포로부터 조작된 DNA 중합효소 폴리펩티드를 회수하는 단계를 포함하는 방법을 제공한다. 일부 실시 양태에서, 숙주 세포는 하나 초과의 조작된 DNA 중합효소 폴리펩티드를 생산한다.
일부 실시 양태에서, 조작된 DNA 중합효소 폴리펩티드가 재조합 숙주 세포 및/또는 배양 배지로부터 회수되면, 이들은 당 업계에 공지된 임의의 적합한 방법(들)에 의해 추가로 정제된다. 일부 추가 실시 양태에서, 정제된 조작된 DNA 중합효소 폴리펩티드는 다른 성분 및 화합물과 조합되어 상이한 적용 분야 및 용도(예를 들어, 진단 방법 및 조성물)에 적합한 조작된 DNA 중합효소 폴리펩티드를 포함하는 조성물 및 제제를 제공한다.
실험
수행한 실험 및 결과를 포함하는 다음 실시예는 예시 목적으로만 제공되며 본 발명을 제한하는 것으로 해석되어서는 안 된다.
아래의 실험 개시 내용에서, 다음 약어가 적용된다: ppm(백만 분율); M(몰); mM(밀리몰), uM 및 μM(마이크로몰); nM(나노몰); mol(몰); gm 및 g(그램); mg(밀리그램); ug 및 μg(마이크로그램); L 및 l(리터); ml 및 mL(밀리리터); cm(센티미터); mm(밀리미터); um 및 μm(마이크로미터); sec.(초); min(분); h 및 hr(시간); Ω(옴); μf(마이크로패럿); U(단위); MW(분자량); rpm(분당 회전); rcf(상대 원심력); psi 및 PSI(제곱 인치당 파운드); ℃(섭씨 온도); RT 및 rt(실온); NGS(차세대 시퀀싱); ds(이중 가닥); ss(단일 가닥); CDS(코딩 서열); DNA(데옥시리보핵산); RNA(리보핵산); 이. 콜라이 W3110(일반적으로 사용되는 실험실 이. 콜라이 균주, 미국 커네티컷주 뉴 헤이븐 소재의 Coli Genetic Stock Center[CGSC]로부터 구입 가능); HTP(high throughput: 고-처리량); HPLC(high pressure liquid chromatography: 고압 액체 크로마토그래피); MCYP(microcyp); ddH2O(2차 증류수); PBS(인산 완충 식염수); BSA(소 혈청 알부민); DTT(디티오트레이톨); CAM(클로람페니콜); CAT(클로람페니콜 아세틸트랜스퍼라아제); IPTG(이소프로필 β-D-1-티오갈락토피라노시드); GFP(녹색 형광 단백질); eGFP(향상된 GFP); DsRed(디스코소마(Disosoma) 종으로부터 단리된 적색 형광 단백질); FIOPC(fold improvement over positive control: 양성 대조군에 대한 개선 배수); LB(Luria-Bertani); SPRI(solid phase reversible immobilization: 고상 역상 고정); Sigma-Aldrich(Sigma-Aldrich, 미국 미주리주 세인트 루이스 소재); Perkin Elmer(Perkin Elmer, Inc, 미국 매사추세츠 월섬 소재); Harvard Apparatus(Harvard Apparatus, 미국 매사추세츠주 홀리스톤 소재); Millipore(Millipore, Corp., 미국 매사추세츠주 빌레리카 소재); Covaris(Covaris, Inc., 미국 매사추세츠주 워번 소재); MagBio(MagBio Genomics, Inc., 미국 메릴랜드주 게이더스버그 소재); Qiagen(Qiagen Inc., 미국 메릴랜드주 제르맨타운 소재); Illumina(Illumina, Inc., 미국 캘리포니아주 샌디에고 소재); BD Biosciences(BD Biosciences, 미국 캘리포니아주 산호세 소재); Difco(Difco Laboratories, BD Diagnostic Systems, 미국 미시간주 디트로이트 소재); Kuhner(Adolf Kuhner, AG, 스위스 바젤 소재); Zymo(Zymo Research, 미국 캘리포니아주 어바인 소재); Agilent(Agilent Technologies, Inc., 미국 캘리포니아주 산타 클라라 소재); Thermo Scientific(Thermo Fisher Scientific의 일부, 미국 매사추세츠 월섬 소재); GE Healthcare(GE Healthcare Bio-Sciences, 미국 뉴저지주 피스캐터웨이 소재); 및 Bio-Rad(Bio-Rad Laboratories, 미국 캘리포니아주 에르쿨레스 소재).
실시예 1
DNA 중합효소 유전자 획득 및 발현 벡터 구축
테르모코쿠스 종 균주 2319x1(Unprot ID A0A0U3SCT0; 서열번호 1 및 2, 각각 폴리뉴클레오티드 및 폴리펩티드 서열)의 게놈에 의해 코딩된 그룹 B 중합효소는 피로코쿠스 퓨리오수스 DNA 중합효소(서열번호 4)와 73% 단백질 서열 동일성을 공유한다. 이 중합효소(서열번호 2)는 본원에서 "Pol3"으로 지칭된다. 명확하게는, 이 효소는 원핵생물 DNA 복제에 관여하는 DNA 중합효소 III 완전효소(holoenzyme)와 동일하지 않다. 야생형(WT) Pol3 중합효소(서열번호 6)의 6-히스티딘 태그된 형태를 코딩하는 합성 유전자(서열번호 5)를 구축하고 에쉐리키아 콜라이 발현 벡터 pCK100900i(예를 들어, 미국 특허 제7,629,157호 및 미국 특허 출원 공개 제2016/0244787호를 참조하며, 이들 둘 모두는 본원에 참고로 포함됨)에 서브클로닝하였다. 이 플라스미드 구축물을 W3110에서 유래된 이. 콜라이 균주로 형질전환시켰다. 당업자에게 일반적으로 알려진 유도 진화 기술을 사용하여 이 플라스미드로부터 유전자 변이체의 라이브러리를 생성하였다(예를 들어, 미국 특허 제8,383,346호 및 WO 2010/144103을 참조하며, 이들 둘 모두는 본원에 참고로 포함됨). 본원에 기재된 효소 변이체의 치환은 표시된 바와 같이 6-히스티딘 태그된 효소(즉, 서열번호 6) 또는 이의 변이체를 참조하여 표시된다.
실시예 2
고-처리량( HTP ) Pol3 DNA 중합효소 발현 및 용해액 제조
이 실시예에서, 중합효소 변이체의 HTP 배양 및 용해액 제조에 사용된 방법을 기재한다.
Pol3 중합효소 및 변이체의 고-처리량 배양
형질전환된 이. 콜라이 세포는 1% 글루코스 및 30 ㎍/ml 클로람페니콜을 함유하는 LB 한천 플레이트에 플레이팅하여 선별하였다. 37℃에서 하룻밤 인큐베이션 후, 콜로니를 1% 글루코오스 및 30 ㎍/ml 클로람페니콜이 보충된 180 ㎕/웰 LB 배지로 채워진 96 웰 얕은 평평 바닥 NUNC™ 마이크로플레이트의 웰에 넣었다. 배양물이 진탕기(200 rpm, 30℃, 및 85% 상대 습도; Kuhner)에서 18 내지 20시간 동안 하룻밤 성장하도록 두었다. 하룻밤 배양 샘플(20 ㎕)을 30 μg/ml 클로람페니콜이 보충된 380㎕의 Terrific Broth로 채워진 Costar 96 웰 깊은 플레이트로 옮겼다. OD600이 0.4 내지 0.8에 도달할 때까지 플레이트를 진탕기(200 rpm, 30℃, 및 85% 상대 습도; Kuhner)에서 120분 동안 인큐베이션하였다. 그런 후 세포를 멸균 수 중 10 mM IPTG 40 ㎕로 유도하고 진탕기(250 rpm, 30℃, 및 85% 상대 습도; Kuhner)에서 18 내지 20시간 동안 하룻밤 인큐베이션하였다. 세포를 펠릿화(4000 rpm x 20분)하고, 상등액을 버리고, 분석 전에 세포를 -80℃에서 냉동시켰다.
HTP 펠릿의 용해
세포 펠릿을 해동시키고 300 ㎕/웰의 용해 완충액(20 mM NaCl, 50 mM Tris-HCl, pH 7.5)에서 실온에서 10분 동안 흔들어 재현탁시켰다. 그런 후, 150 ㎕의 재현탁된 펠릿을 HARDSHELL® PCR 플레이트(Bio-Rad)로 옮겼다. 93℃에서 60분 동안 단일 열 순환기 인큐베이션 단계에서 세포 용해 및 열처리를 수행하였다. 세포 파편 및 열 불용성 물질을 펠릿화(4000 rpm x 10분)하고, 정화된 용해액 상등액을 다음 실시예에 기재된 바와 같이 PCR 분석에 사용하였다.
실시예 3
PCR 생산량 분석
사용된 주형의 길이에 비해 짧은 신장 시간으로 종점 PCR 분석에서 PCR 생산량을 측정하여 함으로써 Pol3 변이체의 선별을 수행하였다. 각 변이체는 80 pg/㎕ MCYP 주형 DNA(서열번호 7), 0.2 mM dNTP, 400 nM 각각의 MCYP 정방향(서열번호 10) 및 역방향(서열번호 11) 프라이머, 20 mM Tris 완충액, pH 8.8, 10 mM KCl, 2 mM MgSO4, 10 mM (NH4)2SO4, 0.1% v/v Triton x-100, 및 0.1 g/L BSA로 구성된 30㎕ 반응에서 스크리닝하였다. 용해액을 20 mM Tris, pH 8.8로 희석하고 5 ㎕의 희석된 용해액을 다음 실시예의 각 표 아래 조건에 나타낸 바와 같이 PCR 마스터 믹스에 최종 농도 0.12 내지 0.58 %(v/v) 용해액으로 첨가하였다. PCR 사이클링은 95℃에서 2분 동안 초기 변성, 이어서 다음의 25 사이클: 95℃ 25초, 51℃ 내지 53℃에서 30초 동안 어닐링, 및 72℃에서 10초 내지 2.25분 동안 신장을 포함하였다. 용해액 농도, 어닐링 온도 및 신장 시간은 실시예의 각 표에 포함되어 있다. 반응 완료 시, 70 ㎕의 ddH2O를 각 반응에 첨가하였다. 3kb MCYP PCR 생성물은 LABCHIP® GX 모세관 전기영동 기기(Perkin-Elmer)에서 DNA 5k 분석을 사용하여 정량화하였다. 표 3.2의 경우, E-gel 96 1% 아가로스 겔(ThermoFisher)에서 전기 영동한 후 생산량을 정성적으로 순위를 매겼다.
[표 3.1]
Figure pct00034
Figure pct00035
[표 3.2]
Figure pct00036
Figure pct00037
Figure pct00038
[표 3.3]
Figure pct00039
[표 3.4]
Figure pct00040
Figure pct00041
[표 3.5]
Figure pct00042
Figure pct00043
Figure pct00044
[표 3.6]
Figure pct00045
Figure pct00046
Figure pct00047
Figure pct00048
[표 3.7]
Figure pct00049
[표 3.8]
Figure pct00050
Figure pct00051
실시예 4: 고-처리량 중합효소 충실도 테스트
콜로니 기반 리포터 분석은 중합효소 충실도를 결정하는 방법으로 잘 확립되어 있다. 이들 분석에서, lacZ(Barnes, Gene 112:29-35 [1992]), lacI(Jozwiakowksi and Connolly, Nucl. Acids Res., 37: e102 [2009]), 및 rpsL(Kitabayashi et al., Biosci. Biotechnol. Biochem., 66: 2194-2200 [2002] 참조)과 같은 리포터 유전자가 복제되며, 클론에서 관찰된 유전자 불활성화 돌연변이의 빈도는 리포터 유전자 복제에 사용되는 DNA 중합효소의 오류율에 비례한다. 오류율은 lacI 또는 lacZ에 대한 X-gal(5-브로모-4-클로로-3-인돌릴 B-D-갈락토피라노시드) 플레이트에서 파란색 또는 흰색 표현형을 가진 콜로니의 비율로서, 또는 rpsL에 대한 선별적 암피실린 또는 스트렙토마이신 한천 플레이트에서 성장하는 콜로니의 비율로 보고한다. 교정(proofreading) DNA 중합효소 오류율이 매우 낮기 때문에(예를 들어, ~ 3 x 10-3), 이들 기술은 관찰된 오류율에 대한 샘플링 오류의 영향을 줄이기 위해 많은 수의 콜로니를 분석해야 한다. 개별 클로닝된 앰플리콘의 직접적인 Sanger 시퀀싱에 비해 간단하고 저렴하지만 이들 분석은 처리량이 제한적이다.
본 발명에서 사용하기 위해 세포 기반 유세포 분석을 사용하여 DNA 중합효소 충실도에 대한 고-처리량 분석을 개발하였다. 유도성 LacI 프로모터의 제어하에 2개의 형광 단백질, eGFP(서열번호 14) 및 야생형 dsRed(서열번호 16)에 대한 유전자를 코딩하는 리포터 플라스미드(서열번호 18)를 구축하였다. 플라스미드는 또한 선별을 위해 클로람페니콜 아세틸트랜스퍼라아제에 대한 유전자를 코딩한다. 이 리포터 플라스미드를 이. 콜라이로 형질전환시키고 IPTG로 유도할 때, 두 형광 단백질은 모두 집단의 대부분의 세포에서 발현된다. 단일 형광 단백질(예를 들어, dsRed)을 발현하는 이. 콜라이 집단은 유전자 발현에서 유도 및 노이즈의 변화로 인해 형광 강도의 넓은 로그 정규 분포를 나타낸다. 따라서 dsRed를 불활성화하는 돌연변이는 유전자 발현에서 노이즈와 구별할 수 없다. 이중 표지된 (eGFP/dsRed) 집단의 세포 중에서 광범위한 유전자 발현이 존재하지만 두 단백질은 그 발현에서 있어 공변한다. 그 결과, dsRed를 발현하지 않고 eGFP를 강하게 발현하는 세포는 극히 드물고, dsRed에서 불활성화 돌연변이를 갖는 (그러나 eGFP 발현을 유지하는) 리포터 플라스미드를 발현하는 세포는 배경과 쉽게 구별된다.
리포터 플라스미드의 전체 서열을 복제하기 위해 변이 중합효소 및 인접한 5' 인산화 프라이머를 사용하여 PCR 반응을 수행한다. PCR 증폭 동안, 중합효소 유도 오류는 리포터 플라스미드에 의해 코딩된 형광 리포터 단백질 중 하나 또는 둘 모두에 도입된다. 복제 생성물을 결찰에 의해 원형화하고 이. 콜라이로 형질전환시켜 야생형과 오류 함유 형질전환체의 혼합 집단이 이중 리포터를 발현하도록 유도한다. 그런 후 유도된 세포 집단을 유세포 분석을 사용하여 분석하여 PCR 오류로 인해 dsRed 발현을 잃었지만 여전히 GFP를 발현하는 세포의 비율을 결정한다. 중요하게는, WT 리포터 플라스미드의 단리된 클론을 48 내지 72시간 동안 유도하고 유세포 분석에 의해 분석할 때 eGFP 만 발현하는 세포의 배경은 극도로 낮다.
실시예 2에서 PCR 반응에 대해 기재된 바와 같이 5' 인산화된 정방향(서열번호 19) 및 역방향(서열번호 20) 프라이머를 사용하여 리포터 구축물을 증폭하였다. 전형적으로, 최종 농도 0.25% 부피/부피 HTP 용해액을 각 DNA 중합효소에 사용하였다. 120 pg/㎕의 최종 농도에서 충실도 리포터 구축물(서열번호 18)로 50 ㎕의 반응을 조립하였다. 사이클링 동안 5분의 신장 시간을 사용하였다. PCR에 의해 DNA 중합효소 변이체에 의해 증폭되지 않는 배경 DNA를 제거하기 위해, 나머지 메틸화된 전장의 리포터 플라스미드 PCR 주형(서열번호 18)을 DpnI 제한 효소를 첨가한 후 37℃에서 15분 동안 인큐베이션하여 단편화하였다.
선형 ssDNA PCR 앰플리콘은 ZR-96 DNA Clean and Concentrator(Zymo)를 사용한 칼럼 정제에 의해 정제하였다. 간략히, 200 ㎕의 제공된 결합 완충액을 50 ㎕ PCR 반응에 첨가하고, 제조업체의 프로토콜에 따라 샘플을 처리하였다. 샘플은 10 내지 50 ㎕의 뉴클레아제 무함유 물에서 용출시켰다.
그런 후 정제된 선형 앰플리콘을 최종 성분 농도가 66 mM Tris-HCl, pH 8.0, 1 mM ATP, 10 mM MgCl2, 1 mM DTT, 50 ng/㎕ DNA 리가아제(미국 특허 출원 제15/972, 919호의 서열번호 38)인 200 ㎕ 결찰 반응에서 20℃에서 1시간 동안 원형화하였다.
그런 후 원형화된 앰플리콘을 ZR-96 DNA Clean and Concentrator(Zymo)를 사용하여 정제하고 농축시켰다. 간략히, 제공된 결합 완충액 600 ㎕를 200 ㎕ 결찰 반응에 첨가하고, 제조업체의 프로토콜을 사용하여 샘플을 처리하였다. 샘플은 12 ㎕의 뉴클레아제 무함유 물에서 용리시켰다.
원형화된 앰플리콘은 BTX ECM®630/HT-100 96 웰 전기 천공 장치(BTX, Harvard Apparatus)를 사용하여 이. 콜라이로 형질전환시켰다. 전기 천공 적격 W3110 이. 콜라이 세포(Agilent)를 동일한 부피의 빙냉 멸균 수로 희석하였다. 그런 후, 50 ㎕의 희석된 세포 현탁액을 3 ㎕의 원형화된 앰플리콘 용리액과 함께 한 웰에 첨가하고 혼합하였다. 혼합물을 2mm 갭이 있는 코팅되지 않은 96 웰 일회용 전기 천공 플레이트(BTX)로 옮겼다. 플레이트를 얼음 위에서 식힌 후, 이. 콜라이 형질 변환을 위한 표준 설정(2500 볼트, 200Ω, 25μf)을 사용하여 펄스를 주었다. 세포를 웰에서 수거하여 500 ㎕의 S.O.C 회복 배지(Invitrogen; Hanahan, J. Mol. Biol., 166: 557-580 [1983] 참조)에 첨가한 후, 37℃에서 진탕하면서 1시간 인큐베이션하여 세포 회복 및 리포터 플라스미드에 존재하는 항생제 내성 마커(클로람페니콜 아세틸트랜스퍼라아제)의 발현을 허용하였다. 1시간 인큐베이션 후, 클로람페니콜(60 ㎍/ml)을 함유하는 500 ㎕의 LB 브로쓰를 웰에 첨가하여 30℃ 또는 37℃에서 하룻밤 성장 중에 리포터 플라스미드에 대해 선별하였다. 또한, 1시간에 성장 세포의 일부를 LB에 1:100으로 희석하고 5 ㎕의 희석된 배양물을 피펫팅을 통해 LB+ CAM+ 1%(v/v) 글루코오스 플레이트로 스팟팅하여 형질전환 효율을 확인하였다. 5개 이상의 콜로니가 있는 스팟에는 최소 105개의 형질전환체가 포함되었다. 일부 웰에서 최대 106개의 형질전환체가 관찰되었다. 블랭크 대조군 웰에 eGFP/dsRed 리포터 구축물(서열번호 18)을 발현하는 이. 콜라이 및 eGFP 만을 발현하는 양성 대조군을 접종하였다.
다음날, 20 ㎕의 하룻밤 배양물을 380 ㎕의 LB 배지에 첨가하여 플레이트를 계대 배양하고 30℃에서 진탕 배양하였다. 2시간 인큐베이션 후, 각 플레이트에 IPTG를 최종 농도 1 mM이 되도록 첨가하였다. 플레이트를 30℃에서 40 내지 72시간 동안 진탕하면서 인큐베이션하여 야생형 dsRed 단백질의 유도 및 완전 성숙을 허용하였다. 유도된 배양물을 원심 분리에 의해 펠릿화하고, 상등액을 따라 내고, 세포를 400 ㎕의 1x PBS에 볼텍싱하여 재현탁하였다. 세포는 유세포 분석을 위해 PBS에 100배 더 희석하였다.
아래 표에 달리 명시되지 않는 한, 자동 시료 주입기가 있는 ACCURI™ C6 유세포 분석기(BD Biosciences)를 사용하여 세포를 분석하였다. eGFP와 dsRed는 모두 488 nm 레이저를 통해 여기시켰고, 형광 보상을 사용하여 eGFP와 dsRed 방출 통로에서 스펙트럼 중첩을 제거하였다. 단일 eGFP 발현(녹색 단독) 및 이중 eGFP/dsRed 발현 세포에 대한 게이트를 각 플레이트에서 해당 대조군 배양을 사용하여 정의하였다. 전형적으로, 녹색 단독 이벤트의 배경 빈도는 eGFP/dsRed 발현 대조군 집단에서는 1x10-5였지만, 고 충실도 중합효소를 사용하는 PCR 증폭 집단에서는 1x10-3 내지 3x10-3 녹색 단독 이벤트의 빈도가 관찰되어서, 배경 차감을 적용하지 않았다. 샘플링 오류를 최소화하기 위해, 총 500개의 녹색 단독 이벤트 또는 샘플당 최대 106개의 총 이벤트에 대해 웰을 분석하였다. 여기에 14 ㎕/분의 유속에서 중합효소 충실도에 따라 샘플당 15 내지 4분이 필요하였다. 각 변이체에 대한 녹색 단독 빈도는 게이트된 녹색 단독 이벤트의 비율을 게이트된 형광 세포 이벤트의 총수로 나누어 계산하였다. 각 변이체의 상대 오류율은 변이체의 녹색 단독 빈도를 모 대조군의 빈도로 나누어 계산하였다. 마지막으로, 아래 표에 보고된 중합효소 충실도의 개선 배수는 상대 오류율의 역수이다.
[표 4.1]
Figure pct00052
[표 4.2]
Figure pct00053
[표 4.3]
Figure pct00054
Figure pct00055
[표 4.4]
Figure pct00056
[표 4.5]
Figure pct00057
실시예 5
중합효소 충실도의 상대적인 비교
변이 DNA 중합효소의 오류율과 PCR에 사용되는 시판되는 DNA 중합효소의 오류율을 고-처리량 유세포 분석을 사용하여 비교하였다. 이 연구의 변이 중합효소를 사용하여 충실도 리포터 플라스미드를 증폭하고, 실시예 4에 기재된 바와 같이 분석하였다. 시판되는 중합효소를 사용하여 중합효소와 함께 제공된 완충액(마그네슘이 첨가되지 않음)을 사용하여 리포터 구축물을 증폭하며, 4.5kb 플라스미드 주형에 대한 제조업체의 권장 사항에 따라 온도 및 열 순환 시간을 사용하였다. 각 중합효소에 사용된 사용 완충액, dNTP의 농도, 어닐링 온도 및 신장 시간은 표 5.1에 나열한다. 각 샘플에 대해 PLATINUM SUPERFI™ DNA 중합효소에 대한 오류율을 계산한 후, KCl 완충액에서 Taq DNA 중합효소와 비교하여 상대 오류율을 계산하였다. [도 1]은 이러한 중합효소의 상대 오류율을 보여준다.
[표 5.1]
Figure pct00058
실시예 6
다중 중합효소 특성에 대한 동시 스크리닝
플라스미드 및 게놈 DNA 주형으로부터 다양한 크기 및 GC 함량의 앰플리콘의 증폭을 기반으로 다양한 적용 분야에 걸쳐 강력한 중합효소 성능을 선택하였다. 후속 라운드에 대한 스크리닝은 완충액 M6a: 30 mM Tris pH 8.8, 10 mM (NH4)2SO4, 13.2 mM KCl, 0.4%(v/v) Triton x-100, 0.5 mg/ml BSA, 1.5 mM MgSO4, 4.5% v/v DMSO에서 수행하였다. 시험 조건에 대한 PCR 조건은 표 6.1에 나와있다. 생산량은 모세관 전기영동을 통해 실시예 3에 기재된 바와 같이 결정하였고, 충실도는 실시예 4에 기재된 바와 같이 측정하였다. 이들 성능시험 실험에서, 상이한 주형을 사용하였다. 표 6.1은 각 시험에 대한 반응 조건, 프라이머, 및 주형을 제공한다. "ARX"는 인간 arx 유전자를 지칭하고; "MCYP"는 microcyp를 지칭한다. "KCL"은 추가의 KCl(4.5mM)과 함께 microcyp 주형을 사용한 시험을 지칭한다. "BRCA"는 인간 BRCA2 유전자를 지칭한다.
[표 6.1]
Figure pct00059
[표 6.2]
Figure pct00060
Figure pct00061
Figure pct00062
Figure pct00063
[표 6.3]
Figure pct00064
실시예 7
차세대 시퀀싱에서 커버리지의 균일성
미생물 게놈의 전체 게놈 시퀀싱을 사용하여 차세대 시퀀싱 적용에서 증폭된 라이브러리의 커버리지의 균일성을 테스트하였다. 본 실험에서 스태필로코쿠스 에피더미스(ATCC 12228: 2.5MB, 32.1% GC) 및 로도박터 스페로이데스(ATCC 17025: 3.22MB, 68.5% GC)의 게놈 DNA를 사용하였다. 각 유기체의 DNA는 초음파 처리(Covaris)를 사용하여 400bp 평균 단편 길이로 전단하였다. 그런 후, 제조업체의 지침(Roche, 제품 KR0961)에 따라 KAPA 이중 색인 어댑터를 사용하여 100 ng의 게놈 DNA를 KAPA Hyper 라이브러리 제조 워크플로우에 입력으로 사용하였다. 결찰된 라이브러리 단편은 MagBio HighPrep™ SPRI 비드를 사용하여 정제하고, 10ng의 입력 DNA를 서열번호 1082의 정제된 중합효소를 사용한 PCR 증폭을 위한 주형으로서 사용하였다. M34b 완충액(30mM Tris pH 8.8, 7mM (NH4)2SO4, 17mM KCl, 0.05%(v/v) TWEEN®-20 계면활성제, 0.5 mg/ml BSA, 2 mM MgSO4, 8% v/v DMSO, 15μM ZnSO4)에서 8 사이클의 PCR 증폭을 수행하였다. 증폭된 물질은 HighPrep SPRI 비드를 사용하여 세척하고 정규화하고 다중 시퀀싱을 위해 풀링하였다. Miseq 시약 키트 v2(2x250bp)를 사용하여 MiSeq 기기(Illumina)에서 라이브러리 풀을 시퀀싱하였다. CLC Genomics(Qiagen) 소프트웨어를 사용하여 리드(read)를 역다중화(demultiplexing)하고, 어댑터 서열을 트리밍한 후, 그들의 각각의 게놈에 정렬하였다. CLC Genomics 리드 맵핑 QC 메트릭을 사용하여 커버리지의 균일성을 결정하였다. [도 2 및 3]은 이 실험의 결과를 제공한다.
본 발명이 특정 실시 양태를 참조하여 기재되었지만, 다양한 변경이 이루어질 수 있고 등가물이 특정 상황, 재료, 물질의 조성, 공정, 공정 단계 또는 단계들에 적합하도록 대체될 수 있으며, 이에 따라 청구된 범위를 벗어나지 않고 본 발명의 이익을 달성할 수 있다.
미국에서의 모든 목적을 위해, 본 개시 내용에 인용된 각각의 모든 간행물 및 특허 문서는 마치 각각의 이러한 간행물 또는 문서가 구체적으로 그리고 개별적으로 본원에 참고로 포함되는 것으로 나타낸 것처럼 본원에 참고로 포함된다. 간행물 및 특허 문서의 인용은 그러한 어떠한 문서도 선행 기술과 관련이 있거나 그 내용이나 날짜에 대해 인정하는 것으로서 의도되지 않는다.
SEQUENCE LISTING <110> CODEXIS, INC. <120> ENGINEERED DNA POLYMERASE VARIANTS <130> CX9-181WO2 <140> PCT/US2019/058310 <141> 2019-10-28 <150> US 62/752,215 <151> 2018-10-29 <160> 1085 <210> 1 <211> 2325 <212> DNA <213> Artificial Sequence <220> <223> DNA polymerase <400> 1 atgattctgg acaccgatta catcaccaaa gatggcaagc cgatcattcg tattttcaag 60 aaagaaaacg gcgagtttaa gatcgagctg gacccgcact ttcagccgta catttatgcg 120 ctgctgaaag acgatagcgc gatcgaggaa attaaagcga tcaagggtga acgtcacggc 180 aaaaccgtgc gtgttctgga cgcggtgaag gttcgtaaga aattcctggg tcgtgaggtg 240 gaagtttgga agctgatctt tgagcacccg caagacgtgc cggcgatgcg tgataagatt 300 aaagaacacc cggcggttat cgacatttac gagtatgata tcccgtttgc gaaacgttac 360 ctgattgaca agggtctgat cccgatggaa ggcgatgagg aactgaagct gctggcgttc 420 gacattgaga ccttttacca cgaaggtgat gagttcggta aaggcgaaat cattatgatc 480 agctatgcgg acgaggaaga ggcgcgtgtg attacctgga agaacatcga cctgccgtac 540 gttgatgtgg ttagcaacga gcgtgaaatg atcaaacgtt ttgtgcaggt ggttaaggag 600 aaagacccgg atgttatcat tacctacaac ggcgacaact tcgatctgcc gtatctgatc 660 aaacgtgcgg aaaagctggg tgtgcgtctg gttctgggcc gtgacaaaga aaacccggag 720 ccgaagatcc aacgtatggg tgatagcttc gcggtggaga ttaaaggccg tatccacttc 780 gacctgtttc cggtggttcg tcgtaccatc aacctgccga cctacaccct ggaagcggtg 840 tatgaggcgg ttctgggcaa gaccaaaagc aagctgggcg cggaagagat tgcggcgatc 900 tgggagaccg aagagagcat gaagaaactg gcgcagtaca gcatggaaga tgcgcgtgcg 960 acctatgaac tgggcaagga gttctttccg atggaggcgg aactggcgaa actgatcggt 1020 caaagcgtgt gggacgttag ccgtagcagc accggcaacc tggtggaatg gtacctgctg 1080 cgtgttgcgt atgcgcgtaa cgagctggcg ccgaacaaac cggatgaaga ggaatacaag 1140 cgtcgtctgc gtaccaccta cctgggtggc tatgtgaaag agccggaaaa gggtctgtgg 1200 gagaacatca tttacctgga ctttcgtagc ctgtatccga gcatcattgt gacccacaac 1260 gttagcccgg acaccctgga gaaggaaggc tgcgaaaact acgatattgc gccgatcgtt 1320 agctatcgtt tctgcaaaga cttcccgggt tttattccga gcatcctggg cgatctgatt 1380 gcgatgcgtc aggagatcaa gaaaaagatg aaggcgacca ttgacccgat cgagaagaag 1440 atgctggatt accgtcaacg tgcggttaaa ctgctggcga acagctacta tggttacatg 1500 ggctatccga aagcgcgttg gtacagcaag gaatgcgcgg agagcgtgac cgcgtggggt 1560 cgtcactata tcgaaatgac cattaaggag atcgaggaaa aattcggctt taaggttctg 1620 tacgcggaca ccgatggttt ctatgcgacc attccgggcg aaaagccgga gatcattaaa 1680 aagaaagcgc gtgagtttct gaactacatc aacagcaaac tgccgggtct gctggagctg 1740 gaatacgagg gtttctatct gcgtggcttc tttgtgacca agaaacgtta tgcggttatt 1800 gatgaggaag gtcgtatcac cacccgtggt ctggaagtgg ttcgtcgtga ctggagcgaa 1860 atcgcgaaag agacccaggc gaaggtgctg gaagcgattc tgaaagacgg tagcgttgaa 1920 aaggcggtgg agattgttcg tgatgtggtt gaaaaaatcg cgaagtaccg tgtgccgctg 1980 gaaaagctgg ttattcacga gcaaatcacc cgtgacctga aagattataa ggcgattggc 2040 ccgcacgtga gcatcgcgaa acgtctggcg acccgtggta tcaaagtgaa gccgggcacc 2100 atcattagct acctggttct gaaaggtagc ggcaagatta gcgaccgtgt tatcctgctg 2160 accgaatacg atccggagaa acacaagtat gacccggatt actatatcga gaaccaggtg 2220 ctgccggcgg ttctgcgtat tctggaagcg ttcggttacc gtaaagagga cctgcgttat 2280 cagagcagca agcaaaccgg cctggatacc tggctgaaac gttaa 2325 <210> 2 <211> 774 <212> PRT <213> Artificial Sequence <220> <223> DNA polymerase <400> 2 Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 1 5 10 15 Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 20 25 30 His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35 40 45 Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 50 55 60 Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 65 70 75 80 Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 85 90 95 Arg Asp Lys Ile Lys Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 130 135 140 Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 145 150 155 160 Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 165 170 175 Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 180 185 190 Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 210 215 220 Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu 225 230 235 240 Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 245 250 255 Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 260 265 270 Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 275 280 285 Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 290 295 300 Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 305 310 315 320 Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 325 330 335 Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 340 345 350 Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 355 360 365 Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 370 375 380 Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 385 390 395 400 Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 405 410 415 Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu 420 425 430 Asn Tyr Asp Ile Ala Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe 435 440 445 Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 450 455 460 Glu Ile Lys Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys 465 470 475 480 Met Leu Asp Tyr Arg Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr 485 490 495 Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 500 505 510 Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 515 520 525 Lys Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 530 535 540 Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys 545 550 555 560 Lys Lys Ala Arg Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 565 570 575 Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 580 585 590 Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 595 600 605 Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 610 615 620 Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu 625 630 635 640 Lys Ala Val Glu Ile Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 645 650 655 Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 660 665 670 Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg 675 680 685 Leu Ala Thr Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 690 695 700 Leu Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 705 710 715 720 Thr Glu Tyr Asp Pro Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 725 730 735 Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 740 745 750 Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 755 760 765 Asp Thr Trp Leu Lys Arg 770 <210> 3 <211> 2325 <212> DNA <213> Artificial Sequence <220> <223> Pfu DNA polymerase <400> 3 atgattctgg atgttgacta catcaccgaa gaaggcaaac cagttatccg cctgttcaaa 60 aaagagaatg gcaagttcaa aatcgagcat gaccgcacat tccgcccgta catttacgca 120 ctgctgcgcg acgattcgaa gatcgaagaa gtgaagaaga ttaccggtga acgtcacggc 180 aagattgtgc gtattgtgga tgttgagaag gtggagaaga agttcctggg caaaccgatt 240 accgtgtgga aactgtatct ggagcatccg caggatgtcc ctaccattcg cgagaaagtc 300 cgtgaacatc cggcagtcgt ggatattttt gagtacgaca tcccatttgc gaaacgctat 360 ctgattgaca aaggtctgat tccgatggaa ggggaagaag aattgaagat tcttgcattt 420 gacattgaaa ccctgtacca cgaaggtgaa gagtttggca aaggtccgat catcatgatt 480 agctacgcgg atgagaacga ggcgaaagtc attacgtgga agaacattga cctgccatac 540 gtagaggtcg taagcagcga gcgcgagatg atcaaacgct ttctgcgcat cattcgtgag 600 aaagatccgg acatcattgt tacctacaac ggcgatagct tcgatttccc ctatctggcc 660 aaacgtgcag agaaactggg tatcaaactg accatcggtc gcgatggtag cgaaccgaag 720 atgcaacgca ttggcgacat gaccgcggtg gaagtaaagg gtcgcattca tttcgatctg 780 tatcatgtga ttacccgcac catcaatctg ccgacctata ctctggaagc cgtgtatgaa 840 gctatcttcg gcaaaccgaa agagaaagtg tatgcagatg agatcgcgaa agcgtgggaa 900 agcggtgaga acctggaacg tgtggcgaag tactcgatgg aagatgctaa agccacctac 960 gagctgggca aagagtttct gccgatggag atccagctga gccgtcttgt tggtcagcca 1020 ctgtgggacg tgagccgcag cagtactggt aatcttgttg agtggttcct gctgcgtaaa 1080 gcctatgaac gtaacgaagt ggcgccgaac aaaccgagcg aagaagaata ccagcgccgc 1140 ctgcgcgaaa gctataccgg tggctttgtg aaagaaccag agaaaggtct gtgggagaac 1200 attgtgtatc tggacttccg tgcactgtac ccaagcatca tcattaccca taacgtgagc 1260 ccggacactc tgaacctgga aggttgtaag aactatgaca tcgcaccgca ggtgggtcat 1320 aagttctgta aagacattcc gggcttcatt ccgagcctgc tggggcacct gctggaagaa 1380 cgccagaaga tcaagacgaa gatgaaagaa actcaggacc cgattgagaa gatcctgctg 1440 gactatcgtc agaaagctat caaactgctg gctaacagct tctacggtta ctatggctat 1500 gcgaaagcgc gttggtattg caaagaatgt gcggaaagcg ttactgcatg gggtcgcaag 1560 tacatcgaac tggtttggaa agaactggag gagaagttcg gcttcaaagt tctgtacatt 1620 gataccgatg gtctgtacgc cacaattccg ggtggtgaat ctgaagaaat caagaagaag 1680 gcactggagt tcgttaagta catcaatagt aagctgccgg gcctgctgga actggaatac 1740 gaaggtttct acaagcgcgg cttctttgtg actaagaagc gctatgccgt gattgatgaa 1800 gaaggcaaag tgattacccg cggtctggag attgtgcgtc gtgattggag cgagattgcg 1860 aaagaaaccc aggctcgtgt tctggaaacc atccttaagc atggcgatgt tgaagaagcc 1920 gtgcgcatcg tcaaagaagt aatccagaag ttagccaact atgagattcc accagagaaa 1980 ctggccatct acgaacagat tacccgccct ttgcatgagt acaaagctat tggtccgcat 2040 gtggcggttg cgaagaaact ggccgcgaaa ggagtaaaga tcaaaccggg catggtgatt 2100 ggctacatcg tgctgcgcgg cgatggcccg attagcaatc gcgcaattct ggccgaagaa 2160 tacgatccta agaagcacaa gtatgatgct gagtactaca tcgagaatca ggtgctgcca 2220 gcagtactgc gcattctgga aggtttcggt taccgcaaag aagatctgcg ctaccagaag 2280 acccgccagg ttggtctgac cagctggctt aacatcaaga aatcc 2325 <210> 4 <211> 775 <212> PRT <213> Artificial Sequence <220> <223> Pfu DNA polymerase <400> 4 Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 1 5 10 15 Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 20 25 30 Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 35 40 45 Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 50 55 60 Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 65 70 75 80 Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 85 90 95 Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 145 150 155 160 Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 165 170 175 Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 180 185 190 Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 195 200 205 Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 210 215 220 Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 225 230 235 240 Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 245 250 255 His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 275 280 285 Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 290 295 300 Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 305 310 315 320 Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 325 330 335 Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 355 360 365 Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 370 375 380 Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 385 390 395 400 Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 405 410 415 His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 420 425 430 Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 435 440 445 Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 450 455 460 Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 465 470 475 480 Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 485 490 495 Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 500 505 510 Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 515 520 525 Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 530 535 540 Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 545 550 555 560 Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 565 570 575 Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 580 585 590 Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 595 600 605 Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 610 615 620 Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 625 630 635 640 Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 645 650 655 Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 660 665 670 Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 675 680 685 Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 690 695 700 Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 705 710 715 720 Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 725 730 735 Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 740 745 750 Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 755 760 765 Trp Leu Asn Ile Lys Lys Ser 770 775 <210> 5 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223>Tagged DNA polymerase <400> 5 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 6 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Tagged DNA polymerase <400> 6 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 7 <211> 3150 <212> DNA <213> Artificial Sequence <220> <223> MCYP plasmid DNA template <400> 7 atgacaataa aggaaatgcc gcagccgaaa acgtttggag aacttaaaaa tttaccgtta 60 ttaaacacag ataaaccggt tcaagctttg atgaaaattg cggatgaatt aggagaaatc 120 tttaaattcg aggcgcctgg ttgtgtaacg cgctacttat caagtcagcg tctaattaaa 180 gaagcatgcg atgaatcacg ctttgataaa aacttaagtc aagcgcttaa atttgcacgt 240 gattttctgg gagacgggtt agcaacaagc tggacgcatg aaataaattg gaaaaaagcg 300 cataatatct tacttccaag ctttagtcag caggcaatga aaggctatca tgcgatgatg 360 gtcgatatcg ccgtgcagct tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt 420 gaagtatcgg aagacatgac acgtttaacg cttgatacaa ttggtctttg cggctttaac 480 tatcgcttta acagctttta ccgagatcag cctcatccat ttattataag tatggtccgt 540 gcactggatg aagtaatgaa caagctgcag cgagcaaatc cagacgaccc agcttatgat 600 gaaaacaagc gccagtgtca agaagatatc aaggtgatga acgacctagt agataaaatt 660 attgcagatc gcaaagcaag gggtgaacaa agcgatgatt tattaacgca gatgctaaac 720 ggaaaagatc cagaaacggg tgagccgctt gatgacggga acattagcta tcaaattatt 780 acattcttaa ttgcgggaca cgaaacaaca agtggtcttt tatcatttgc gctgtatttc 840 ttagtgaaaa atccacatgt attacaaaaa gtagcagaag aagcagcacg agttctagta 900 gatcctgttc caagctacaa acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac 960 gaagcgctgc gcttatggcc aactgctcct gcgttttccc tatatgcaaa agaagatacg 1020 gtgcttggag gagaatatcc tttagaaaaa ggcgacgaag taatggttct gattcctcag 1080 cttcaccgtg ataaaacaat ttggggagac gatgtggagg agttccgtcc agagcgtttt 1140 gaaaatccaa gtgcgattcc gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg 1200 tgtatcggtc agcagttcgc tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa 1260 cactttgact ttgaagatca tacaaactac gagctcgata ttaaagaaac tttaacgtta 1320 aaacctgaag gctttgtggt aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct 1380 tcacctagca ctgaacagtc tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat 1440 acgccgctgc ttgtgctata cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat 1500 ttagcagata ttgcaatgag caaaggattt gcaccgcagg tcgcaacgct tgattcacac 1560 gccggaaatc ttccgcgcga aggagctgta ttaattgtaa cggcgtctta taacggtcat 1620 ccgcctgata acgcaaagca atttgtcgac tggttagacc aagcgtctgc tgatgaagta 1680 aaaggcgttc gctactccgt atttggatgc ggcgataaaa actgggctac tacgtatcaa 1740 aaagtgcctg cttttatcga tgaaacgctt gccgctaaag gggcagaaaa catcgctgac 1800 cgcggtgaag cagatgcaag cgacgacttt gaaggcacat atgaagaatg gcgtgaacat 1860 atgtggagtg acgtagcagc ctactttaac ctcgacattg aaaacagtga agataataaa 1920 tctactcttt cacttcaatt tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac 1980 ggtgcgtttt caacgaacgt cgtagcaagc aaagaacttc aacagccagg cagtgcacga 2040 agcacgcgac atcttgaaat tgaacttcca aaagaagctt cttatcaaga aggagatcat 2100 ttaggtgtta ttcctcgcaa ctatgaagga atagtaaacc gtgtaacagc aaggttcggc 2160 ctagatgcat cacagcaaat ccgtctggaa gcagaagaag aaaaattagc tcatttgcca 2220 ctcgctaaaa cagtatccgt agaagagctt ctgcaatacg tggagcttca agatcctgtt 2280 acgcgcacgc agcttcgcgc aatggctgct aaaacggtct gcccgccgca taaagtagag 2340 cttgaagcct tgcttgaaaa gcaagcctac aaagaacaag tgctggcaaa acgtttaaca 2400 atgcttgaac tgcttgaaaa atacccggcg tgtgaaatga aattcagcga atttatcgcc 2460 cttctgccaa gcatacgccc gcgctattac tcgatttctt catcacctcg tgtcgatgaa 2520 aaacaagcaa gcatcacggt cagcgttgtc tcaggagaag cgtggagcgg atatggagaa 2580 tataaaggaa ttgcgtcgaa ctatcttgcc gagctgcaag aaggagatac gattacgtgc 2640 tttatttcca caccgcagtc agaatttacg ctgccaaaag accctgaaac gccgcttatc 2700 atggtcggac cgggaacagg cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag 2760 ctaaaagaac aaggacagtc acttggagaa gcacatttat acttcggctg ccgttcacct 2820 catgaagact atctgtatca agaagagctt gaaaacgccc aaagcgaagg catcattacg 2880 cttcataccg ctttttctcg catgccaaat cagccgaaaa catacgttca gcacgtaatg 2940 gaacaagacg gcaagaaatt gattgaactt cttgatcaag gagcgcactt ctatatttgc 3000 ggagacggaa gccaaatggc acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac 3060 gttcaccaag tgagtgaagc agacgctcgc ttatggctgc agcagctaga agaaaaaggc 3120 cgatacgcaa aagacgtgtg ggctgggtaa 3150 <210> 8 <211> 658 <212> DNA <213> Artificial Sequence <220> <223>Human ARX template <400> 8 ccaaggcgtc gaagtctggt ggtgcgcggt ccccgcacgc ctgggcctag gcactggggg 60 agcaactgcg ggcgggcccc ggcagcagcc ctggctggga ctccccggcc ggccggctgg 120 ctgatagctc tcccttgccc gcaggctccc ctaagagcag cagcgccccg ttcgaggccg 180 agctgcacct gccgcccaag ctgcggcgcc tgtacggccc gggcgggggc cgcctccttc 240 agggtgcggc agcggcggcg gcggcggcgg cggcggcggc ggcagcggcc gccacggcca 300 cggcgggtcc acgcggggag gcccctccgc cgccaccgcc aaccgcgcgg cccggggaac 360 ggccggacgg cgcaggggcc gccgcggcag ccgcggccgc ggccgccgcg gcctgggaca 420 cgctcaagat cagccaggcg ccgcaggtga gcatcagccg cagcaagtcg taccgcgaga 480 acggggcgcc cttcgtgccg ccgccgcccg cgctggacga gctgggcggc ccggggggcg 540 tcacgcaccc ggaggagcgc ctcggcgtgg ccggcggccc gggcagcgcc ccggctgcgg 600 gtggtggcac cggcaccgag gacgacgagg aggagctgct ggaggacgaa gaagatga 658 <210> 9 <211> 536 <212> DNA <213> Artificial Sequence <220> <223> Human beta globin template <400> 9 ggttggccaa tctactccca ggagcaggga gggcaggagc cagggctggg cataaaagtc 60 agggcagagc catctattgc ttacatttgc ttctgacaca actgtgttca ctagcaacct 120 caaacagaca ccatggtgca cctgactcct gaggagaagt ctgccgttac tgccctgtgg 180 ggcaaggtga acgtggatga agttggtggt gaggccctgg gcaggttggt atcaaggtta 240 caagacaggt ttaaggagac caatagaaac tgggcatgtg gagacagaga agactcttgg 300 gtttctgata ggcactgact ctctctgcct attggtctat tttcccaccc ttaggctgct 360 ggtggtctac ccttggaccc agaggttctt tgagtccttt ggggatctgt ccactcctga 420 tgctgttatg ggcaacccta aggtgaaggc tcatggcaag aaagtgctcg gtgcctttag 480 tgatggcctg gctcacctgg acaacctcaa gggcaccttt gccacactga gtgagc 536 <210> 10 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> MCYP forward PCR primer <400> 10 aattaggaga aatctttaaa ttcgaggcgc 30 <210>11 <211> 24 <212> DNA <213> Artificial Sequence <220> <223>MCYP Rv primer <400> 11 ttcttctagc tgctgcagcc ataa 24 <210> 12 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> ARX forward primer <400> 12 ccaaggcgtc gaagtctg 18 <210> 13 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> ARX Rv primer <400> 13 tcatcttctt cgtcctccag 20 <210> 14 <211> 726 <212> DNA <213> Artificial Sequence <220> <223> eGFP <400> 14 atggtaagca aaggcgaaga attgtttacg ggtgttgttc caatcctggt tgaactggat 60 ggtgatgtta acggtcacaa atttagcgtg agcggcgaag gtgaaggcga tgcaacttat 120 ggcaaactga ccctgaaatt tatttgcact acagggaaac tgccggtgcc gtggccaacc 180 ctggttacca ccctgaccta tggcgttcag tgttttagcc gctacccgga ccacatgaag 240 cagcacgatt ttttcaaaag cgcaatgcca gaaggctatg tacaggaacg caccatcttc 300 tttaaagatg atggcaacta taaaacccgt gcggaagtca aatttgaagg tgacaccctg 360 gttaatcgta ttgaattgaa aggtattgat tttaaagaag acggtaatat cctgggacat 420 aaactggagt ataactataa ctcccacaat gtgtatatca tggcagataa gcagaaaaac 480 ggcattaagg tgaatttcaa aattcgtcat aatatcgaag atggtagtgt acagctggcc 540 gatcattacc agcagaatac cccgatcggc gatggaccag tactgctgcc ggataatcat 600 tatctgagca cccagtcggc tctgagcaaa gatccgaacg aaaaacgcga ccacatggta 660 ctgctggagt ttgttaccgc cgctggtatc acactgggca tggatgagct gtataaatat 720 taatga 726 <210> 15 <211> 240 <212> PRT <213> Artificial Sequence <220> <223> eGFP <400> 15 Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 1 5 10 15 Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 20 25 30 Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 35 40 45 Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 50 55 60 Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 65 70 75 80 Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 85 90 95 Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 100 105 110 Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 115 120 125 Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 130 135 140 Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 145 150 155 160 Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 165 170 175 Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 180 185 190 Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 195 200 205 Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 210 215 220 Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Tyr 225 230 235 240 <210> 16 <211> 675 <212> DNA <213> Artificial Sequence <220> <223> dsRed <400> 16 atgcgtagca gcaaaaacgt tattaaagaa tttatgcgct ttaaagtccg tatggaaggc 60 acagtgaatg gtcatgagtt tgagatcgaa ggtgaaggag aaggacgccc gtatgaaggt 120 cacaataccg tgaagctgaa ggtgactaaa ggtggcccgt taccatttgc atgggacatt 180 ctgagcccac agttccagta cggcagcaag gtctatgtga aacacccggc ggatattccg 240 gactacaaga agctgagctt tccggaaggt ttcaaatggg aacgtgttat gaacttcgaa 300 gatggtggtg tagtgactgt tacccaggat agcagtttac aagacggctg cttcatctac 360 aaggtgaagt tcatcggtgt gaattttccg agcgatggcc cggtcatgca aaaaaagacg 420 atggggtggg aagcaagtac tgagcgctta tatccacgcg atggtgtttt aaaaggggaa 480 atccataagg cactgaagct gaaagacggc ggtcattatc tggtcgagtt caagagcatc 540 tacatggcga aaaagccggt gcaactgccg ggttattatt atgttgactc taagctggac 600 attacctctc ataacgaaga ctataccatc gtggaacagt acgaacgcac cgaaggtcgc 660 catcacctgt tcctg 675 <210> 17 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> dsRed <400> 17 Met Arg Ser Ser Lys Asn Val Ile Lys Glu Phe Met Arg Phe Lys Val 1 5 10 15 Arg Met Glu Gly Thr Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 20 25 30 Gly Glu Gly Arg Pro Tyr Glu Gly His Asn Thr Val Lys Leu Lys Val 35 40 45 Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 50 55 60 Phe Gln Tyr Gly Ser Lys Val Tyr Val Lys His Pro Ala Asp Ile Pro 65 70 75 80 Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val 85 90 95 Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser 100 105 110 Leu Gln Asp Gly Cys Phe Ile Tyr Lys Val Lys Phe Ile Gly Val Asn 115 120 125 Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu 130 135 140 Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu 145 150 155 160 Ile His Lys Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val Glu 165 170 175 Phe Lys Ser Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr 180 185 190 Tyr Tyr Val Asp Ser Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 195 200 205 Thr Ile Val Glu Gln Tyr Glu Arg Thr Glu Gly Arg His His Leu Phe 210 215 220 Leu 225 <210> 18 <211> 4601 <212> DNA <213> Artificial Sequence <220> <223> Fidelity reporter plasmid <400> 18 tcgagttaat taaggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc 60 accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata 120 acaatttcac acaggaaacg gctatgacca tgattacgga ttcactggcc gtcgttttac 180 aatctagagg ccagcctggc cataaggaga tatacatatg gtaagcaaag gcgaagaatt 240 gtttacgggt gttgttccaa tcctggttga actggatggt gatgttaacg gtcacaaatt 300 tagcgtgagc ggcgaaggtg aaggcgatgc aacttatggc aaactgaccc tgaaatttat 360 ttgcactaca gggaaactgc cggtgccgtg gccaaccctg gttaccaccc tgacctatgg 420 cgttcagtgt tttagccgct acccggacca catgaagcag cacgattttt tcaaaagcgc 480 aatgccagaa ggctatgtac aggaacgcac catcttcttt aaagatgatg gcaactataa 540 aacccgtgcg gaagtcaaat ttgaaggtga caccctggtt aatcgtattg aattgaaagg 600 tattgatttt aaagaagacg gtaatatcct gggacataaa ctggagtata actataactc 660 ccacaatgtg tatatcatgg cagataagca gaaaaacggc attaaggtga atttcaaaat 720 tcgtcataat atcgaagatg gtagtgtaca gctggccgat cattaccagc agaatacccc 780 gatcggcgat ggaccagtac tgctgccgga taatcattat ctgagcaccc agtcggctct 840 gagcaaagat ccgaacgaaa aacgcgacca catggtactg ctggagtttg ttaccgccgc 900 tggtatcaca ctgggcatgg atgagctgta taaatattaa tgaggccaaa ctggccacca 960 tcaccatcac cattagggaa gagcagatgg gcaagcttaa ggagataata ctatgcgtag 1020 cagcaaaaac gttattaaag aatttatgcg ctttaaagtc cgtatggaag gcacagtgaa 1080 tggtcatgag tttgagatcg aaggtgaagg agaaggacgc ccgtatgaag gtcacaatac 1140 cgtgaagctg aaggtgacta aaggtggccc gttaccattt gcatgggaca ttctgagccc 1200 acagttccag tacggcagca aggtctatgt gaaacacccg gcggatattc cggactacaa 1260 gaagctgagc tttccggaag gtttcaaatg ggaacgtgtt atgaacttcg aagatggtgg 1320 tgtagtgact gttacccagg atagcagttt acaagacggc tgcttcatct acaaggtgaa 1380 gttcatcggt gtgaattttc cgagcgatgg cccggtcatg caaaaaaaga cgatggggtg 1440 ggaagcaagt actgagcgct tatatccacg cgatggtgtt ttaaaagggg aaatccataa 1500 ggcactgaag ctgaaagacg gcggtcatta tctggtcgag ttcaagagca tctacatggc 1560 gaaaaagccg gtgcaactgc cgggttatta ttatgttgac tctaagctgg acattacctc 1620 tcataacgaa gactatacca tcgtggaaca gtacgaacgc accgaaggtc gccatcacct 1680 gttcctgtaa tgaaagcttg acctgtgaag tgaaaaatgg cgcacattgt gcgacatttt 1740 tttttgaatt ctacgtaaaa agccgccgat acatcggctg cttttttttt gatagaggtt 1800 caaacttgtg gtataatgaa ataagatcac tccggggcgt attttttgag ttatcgagat 1860 tttcaggagc taaggaagct aaaatggaga aaaaaatcac tggatatacc accgttgata 1920 tatcccaatg gcatcgtaaa gaacattttg aggcatttca gtcagttgct caatgtacct 1980 ataaccagac cgttcagctg gatattacgg cctttttaaa gaccgtaaag aaaaataagc 2040 acaagtttta tccggccttt attcacattc ttgcccgcct gatgaatgct catccggagt 2100 tccgtatggc aatgaaagac ggtgagctgg tgatatggga tagtgttcac ccttgttaca 2160 ccgttttcca tgagcaaact gaaacgtttt catcgctgtg gagcgagtat catgatgact 2220 ttcgccaatt cctgcatata tattcgcaag atgtggcgtg ttacggtgaa aacctggcct 2280 atttccctaa agggtttatt gagaatatgt ttttcgtctc agccaatccc tgggtgagtt 2340 tcaccagttt tgatttaaac gtggccaata tggacaactt cttcgccccc gttttcacca 2400 tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc gctggcgatt caggttcatc 2460 atgccgtctg tgatggcttc catgtcggca gaatgcttaa tgaattacaa cagtactgcg 2520 atgagtggca gggcggggcg taactgcagg agctcaaaca gcagcctgta ttcaggctgc 2580 ttttttcgtt ttggtctgcg cgtaatctct tgctctgaaa acgaaaaaac cgccttgcag 2640 ggcggttttt cgaaggttct ctgagctacc aactctttga accgaggtaa ctggcttgga 2700 ggagcgcagt caccaaaact tgtcctttca gtttagcctt aaccggcgca tgacttcaag 2760 actaactcct ctaaatcaat taccagtggc tgctgccagt ggtgcttttg catgtctttc 2820 cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcggact gaacgggggg 2880 ttcgtgcata cagtccagct tggagcgaac tgcctacccg gaactgagtg tcaggcgtgg 2940 aatgagacaa acgcggccat aacagcggaa tgacaccggt aaaccgaaag gcaggaacag 3000 gagagcgcac gagggagccg ccagggggaa acgcctggta tctttatagt cctgtcgggt 3060 ttcgccacca ctgatttgag cgtcagattt cgtgatgctt gtcagggggg cggagcctat 3120 ggaaaaacgg ctttgccgcg gccctctcac ttccctgtta agtatcttcc tggcatcttc 3180 caggaaatct ccgccccgtt cgtaagccat ttccgctcgc cgcagtcgaa cgaccgagcg 3240 tagcgagtca gtgagcgagg aagcggaata tatcctgtat cacatattct gctgacgcac 3300 cggtgcagcc ttttttctcc tgccacatga agcacttcac tgacaccctc atcagtgaac 3360 caccgctggt agcggtggtt tttttaggcc tatggccttt tttttttgtg ggaaaccttt 3420 cgcggtatgg tattaaagcg cccggaagag agtcaattca gggtggtgaa tgtgaaacca 3480 gtaacgttat acgatgtcgc agagtatgcc ggtgtctctt atcagaccgt ttcccgcgtg 3540 gtgaaccagg ccagccacgt ttctgcgaaa acgcgggaaa aagtggaagc ggcgatggcg 3600 gagctgaatt acattcccaa ccgcgtggca caacaactgg cgggcaaaca gtcgttgctg 3660 attggcgttg ccacctccag tctggccctg cacgcgccgt cgcaaattgt cgcggcgatt 3720 aaatctcgcg ccgatcaact gggtgccagc gtggtggtgt cgatggtaga acgaagcggc 3780 gtcgaagcct gtaaagcggc ggtgcacaat cttctcgcgc aacgcgtcag tgggctgatc 3840 attaactatc cgctggatga ccaggatgcc attgctgtgg aagctgcctg cactaatgtt 3900 ccggcgttat ttcttgatgt ctctgaccag acacccatca acagtattat tttctcccat 3960 gaagacggta cgcgactggg cgtggagcat ctggtcgcat tgggtcacca gcaaatcgcg 4020 ctgttagcgg gcccattaag ttctgtctcg gcgcgtctgc gtctggctgg ctggcataaa 4080 tatctcactc gcaatcaaat tcagccgata gcggaacggg aaggcgactg gagtgccatg 4140 tccggttttc aacaaaccat gcaaatgctg aatgagggca tcgtttccac tgcgatgctg 4200 gttgccaacg atcagatggc gctgggcgca atgcgcgcca ttaccgagtc cgggctgcgc 4260 gttggtgcgg acatctcggt agtgggatac gacgataccg aagacagctc atgttatatc 4320 ccgccgttaa ccaccatcaa acaggatttt cgcctgctgg ggcaaaccag cgtggaccgc 4380 ttgctgcaac tctctcaggg ccaggcggtt aagggcaatc agctgttgcc cgtctcactg 4440 gtgaaaagaa aaaccaccct ggcgcccaat acgcaaaccg cctctccccg cgcgttggcc 4500 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcggta 4560 cccgataaaa gcggcttcct gacaggaggc cgttttgttt c 4601 <210> 19 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reporter forward primer <400> 19 gactttcgcc aattcctgca t 21 <210> 20 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Reporter reverse primer <400> 20 atcatgatac tcgctccaca g 21 <210> 21 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 21 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 22 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 22 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 23 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 23 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 24 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 24 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 25 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 25 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 26 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 26 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 27 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 27 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 28 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 28 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 29 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 29 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 30 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 30 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 31 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 31 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacatgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcccgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 32 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 32 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Met Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 33 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 33 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 actgaaaaac tggcgaagta cgaggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 34 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 34 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Thr Glu Lys Leu Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 35 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 35 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaggtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgctatcctg ctgactgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 36 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 36 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Ala Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 37 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 37 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgctatcctg ctgactgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 38 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 38 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Ala Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 39 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 39 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 40 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 40 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 41 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 41 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 42 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 42 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 43 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 43 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta cgaggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 44 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 44 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 45 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 45 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 46 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 46 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 47 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 47 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctggaggaat acgatccgcg taaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 48 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 48 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Glu Glu Tyr Asp Pro 725 730 735 Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 49 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 49 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 actgaaaaaa tcgcgaagta cgaggtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accgttatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 50 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 50 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Thr Glu Lys Ile Ala Lys Tyr Glu Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 51 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 51 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gtcgaaaaaa tcgcgaagta cgaggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 52 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 52 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 53 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 53 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accgttatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctggaggaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 54 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 54 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Glu Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 55 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 55 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaac tggcgaagta cgaggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accgttatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgactgaat acgatccgcg taaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 56 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 56 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Leu Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 57 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 57 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 58 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 58 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 59 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 59 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 actgaaaaaa tcgcgaagta cgaggtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgactgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 60 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 60 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Thr Glu Lys Ile Ala Lys Tyr Glu Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 61 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 61 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta cgaggtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accgttatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 62 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 62 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 63 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 63 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaac tggcgaagta cgaggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgctatcctg ctggaggaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 64 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 64 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Leu Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Ala Ile Leu Leu Glu Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 65 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 65 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 66 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 66 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 67 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 67 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 actgaaaaac tggcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 68 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 68 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Thr Glu Lys Leu Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 69 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 69 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaagctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgctggagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 70 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 70 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Lys Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Leu Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 71 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 71 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaac tggcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 72 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 72 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Leu Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 73 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 73 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 actgaaaaac tggcgaagta cgaggtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgcg taaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 74 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 74 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Thr Glu Lys Leu Ala Lys Tyr Glu Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 75 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 75 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 gaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcacggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacgg ggaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atccgtctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaaaaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgcgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgatcg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 76 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 76 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Thr Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Gly Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Arg Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 77 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 77 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgagtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 78 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 78 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Ser Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 79 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 79 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 80 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 80 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 81 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 81 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttattt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 actgaaaaac tggcgaagta cgaggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accgttatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 82 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 82 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Leu Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Thr Glu Lys Leu Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 83 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 83 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacgg ggaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaagctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaaaaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgctggagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 84 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 84 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Gly Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Lys Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Leu Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 85 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 85 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 gaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 86 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 86 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 87 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 87 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 actgaaaaac tggcgaagta cgaggtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 88 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MYCP combis <400> 88 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Thr Glu Lys Leu Ala Lys Tyr Glu Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 89 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 89 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 90 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 90 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 91 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 91 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaggctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 92 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 92 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Arg Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 93 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 93 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttgcg 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 94 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 94 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Ala Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 95 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 95 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 96 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 96 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 97 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 97 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc gtaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 98 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 98 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Arg Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 99 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 99 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat cacctgtcgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 100 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 100 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Cys Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 101 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 101 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttcgga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 102 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 102 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Arg Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 103 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 103 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gcgcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 104 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 104 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Ala Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 105 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 105 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ctgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 106 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 106 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Cys Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 107 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 107 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtg gtcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 108 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 108 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Gly Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 109 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 109 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgctcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 110 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 110 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 111 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 111 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctgggg 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 112 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 112 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Gly Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 113 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 113 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 tggttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 114 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 114 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Trp Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 115 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 115 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga ggtgcacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 116 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 116 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Val His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 117 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 117 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgtgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat cacctttcgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 118 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 118 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Val Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Phe Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 119 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 119 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 tcgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgcggga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 120 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 120 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Ser Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 121 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 121 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gcacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctgcat 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 122 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 122 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro His 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu His Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 123 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 123 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttatt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 124 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 124 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Ile Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 125 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 125 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttggg 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 126 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 126 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gly Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 127 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 127 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt tcgccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 128 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 128 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 129 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 129 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgtttgcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 130 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 130 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Phe Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 131 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 131 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gtctgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 132 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 132 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 133 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 133 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccgtgcgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 134 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 134 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Val Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 135 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 135 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 cgtttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 136 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 136 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Arg Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 137 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 137 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gtgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagtctatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 138 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 138 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Cys Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Ser Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 139 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 139 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga tcacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggattg tgaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 140 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 140 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp His Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Cys Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 141 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 141 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtcgg 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 142 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 142 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Arg Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 143 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 143 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaaggt aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 144 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 144 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gly Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 145 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 145 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtcg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 146 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 146 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Arg Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 147 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 147 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 cagctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 148 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 148 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Gln Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 149 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 149 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttgtt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 150 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 150 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Val Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 151 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 151 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttaag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 152 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 152 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Lys Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 153 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 153 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 ggtaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 154 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 154 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 155 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 155 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 tggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 156 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 156 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Trp Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 157 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 157 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgcgggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 158 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 158 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Arg Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 159 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 159 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 actgaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 160 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 160 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Thr Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 161 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 161 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgggggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 162 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 162 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Gly Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 163 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 163 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt ggcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 164 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 164 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ala 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 165 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 165 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgactta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 166 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 166 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 167 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 167 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gtttgtaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 168 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 168 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Cys Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 169 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 169 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgt gtgttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 170 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 170 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Cys Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 171 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 171 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc ggtatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 172 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 172 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Gly Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 173 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 173 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 174 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 174 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 175 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 175 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 cgtggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 176 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 176 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Arg Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 177 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 177 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacctgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gagtgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 178 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 178 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Leu His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 179 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 179 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgta tgcgtaccac ctaccggggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 180 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 180 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Met Arg Thr Thr Tyr Arg Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 181 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 181 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca tgccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctggctggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 182 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 182 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Met Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Ala Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 183 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 183 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacaaca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcgct ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 184 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 184 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Asn Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Ala Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 185 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 185 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaaccggta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 186 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 186 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Arg Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 187 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 187 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagctgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 188 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 188 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Cys Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 189 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 189 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaagcgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 190 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 190 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Ala Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 191 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 191 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 atgctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 192 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 192 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Met Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 193 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 193 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacag aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 194 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 194 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 195 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 195 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaagct aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 196 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 196 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Ala Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 197 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 197 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtgtt 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 198 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 198 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Val Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 199 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 199 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtacg 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 200 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 200 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Thr Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 201 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 201 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 atgaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 202 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 202 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Met Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 203 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 203 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agccggggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 204 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 204 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Arg Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 205 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 205 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 cctgaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 206 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 206 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Pro Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 207 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 207 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgta cgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 208 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 208 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Thr Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 209 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 209 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcaaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 210 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 210 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asn Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 211 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 211 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgta atcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 212 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 212 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Asn Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 213 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 213 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta cttggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 214 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 214 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Leu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 215 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 215 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tgtggattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 216 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 216 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Trp Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 217 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 217 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaggga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 218 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 218 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 219 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 219 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggagagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 220 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 220 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 221 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 221 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 acgggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 222 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 222 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Thr Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 223 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 223 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaaa 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctgttt 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 224 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 MCYP SNOCAPS <400> 224 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Phe Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 225 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 225 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaaattctgg cgaacagctt ttatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ctatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tggcgatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 226 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 226 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 227 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 227 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 gggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgta cccgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttgct 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gtcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgcgcga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 acgggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 228 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 228 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Thr Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Ala Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Thr Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 229 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 229 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 tcgaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gtcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgcgcga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gtcgaaaaaa tcgcgaagta cctggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 tcgggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 230 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 230 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Leu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 231 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 231 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 gggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt ggcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgcgcga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 232 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 232 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ala 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 233 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 233 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtg gccgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttaag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagtta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 234 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 234 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Gly Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Lys Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 235 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 235 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 gggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgta cccgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttgct 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt ggcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 236 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 236 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Thr Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Ala Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ala 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 237 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 237 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 tcgaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gtcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cctggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 238 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 238 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Leu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 239 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 239 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 240 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 240 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 241 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 241 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 242 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 242 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 243 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 243 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 gggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gtcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgcgcga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 acgggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 244 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 244 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Thr Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 245 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 245 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gtcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 246 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 246 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 247 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 247 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 tggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgta cccgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttgct 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgcgcga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 acgggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 248 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 248 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Trp Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Thr Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Ala Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Thr Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 249 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 249 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 gggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt ggcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 250 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 250 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ala 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 251 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 251 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgata acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagt 1080 atgaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gctcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcag attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 252 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 252 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Met Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Ala Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 253 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 253 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaatctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat cacctgccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 254 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 254 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Cys Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 255 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 255 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 gggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgcgcga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 tcgggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 256 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 256 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Arg Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 257 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 257 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg tggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 gggaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgta cccgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta cctggtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 acgggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 258 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 258 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Val Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Gly Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Thr Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Leu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Thr Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 259 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 259 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgata acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtact 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agtctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gagatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaagtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agtggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 260 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 260 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Thr Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 261 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 261 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gtcggcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgacgta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 262 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP combis <400> 262 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Ser 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Thr Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 263 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 263 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attacgctca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 264 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 264 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Ala 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 265 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 265 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 266 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 266 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 267 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 267 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gaatgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc aatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 268 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 268 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Asn Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 269 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 269 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggc gcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 270 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 270 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Ala Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 271 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 271 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atggtggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 272 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 272 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Val Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 273 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 273 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagctt aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 274 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 274 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Leu Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 275 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 275 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaatg 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 276 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 276 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Met 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 277 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 277 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagtac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 278 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 278 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu Tyr Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 279 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 279 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag cttatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 280 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 280 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Leu Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 281 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 281 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 282 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 282 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 283 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 283 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagcagaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 284 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 284 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Gln Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 285 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 285 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 286 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 286 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 287 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 287 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgtgaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 288 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 288 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Val Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 289 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 289 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 290 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 290 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 291 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 291 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgtaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 292 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 292 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 293 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 293 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgttat 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 294 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 294 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Tyr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 295 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 295 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aacttggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca atgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 296 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 296 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Cys Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 297 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 297 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacgtgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 298 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 298 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Val Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 299 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 299 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaagat 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 300 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 2 MCYP SNOCAPS <400> 300 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Asp 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 301 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 301 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagatgttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 302 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 302 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Met Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 303 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 303 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 304 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 304 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 305 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 305 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaaa aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 306 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 306 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 307 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 307 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 308 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 308 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 309 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 309 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 310 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 310 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 311 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 311 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 312 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 312 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 313 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 313 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 314 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 314 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 315 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 315 atgcatcacc atcaccatca cggtggcagc ggtatgattc tgaacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgatta acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagctg aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 316 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 316 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asn Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asn Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Leu Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 317 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 317 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 318 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 318 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 319 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 319 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 320 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 320 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 321 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 321 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 322 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 322 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 323 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 323 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 tttgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 324 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 324 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 325 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 325 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 326 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 326 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 327 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 327 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 328 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 328 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 329 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 329 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 330 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 330 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 331 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 331 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 332 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 332 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 333 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 333 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 actgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 334 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 334 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Thr Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 335 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 335 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 336 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 336 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 337 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 337 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 338 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 338 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 339 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 339 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 340 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 340 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 341 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 341 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 342 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 342 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 343 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 343 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 344 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 344 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 345 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 345 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 gccattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 346 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 346 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Ala Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 347 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 347 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgcgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 348 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 348 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 349 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 349 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 350 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 350 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 351 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 351 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacaa aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 352 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 352 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 353 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 353 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 actgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 354 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 354 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Thr Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 355 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 355 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 356 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 356 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 357 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 357 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagctg aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 actgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 358 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 358 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Leu Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Thr Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 359 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 359 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 360 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 360 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 361 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 361 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 362 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 362 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 363 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 363 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagctg aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 actgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 364 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 364 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Leu Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Thr Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 365 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 365 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 366 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 366 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 367 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 367 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttggc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 368 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 368 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gly Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 369 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 369 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 370 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 370 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 371 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 371 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg tggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 372 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 372 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Val Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 373 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 373 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 374 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 374 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 375 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 375 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 376 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 376 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 377 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 377 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacaa aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 378 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 378 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 379 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 379 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 380 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 380 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu His Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 381 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 381 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 382 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 382 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 383 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 383 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgggcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 384 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 384 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Gly Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 385 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 385 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaaa aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 386 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 386 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 387 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 387 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 388 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 388 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 389 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 389 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacaa aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaaa gacatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 390 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 390 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Asp Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 391 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 391 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 392 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 392 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 393 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 393 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaaa aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 394 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 394 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 395 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 395 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 396 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 396 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 397 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 397 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacaa aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 398 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 398 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 399 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 399 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 400 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 400 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 401 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 401 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagctg aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 402 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 402 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Leu Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 403 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 403 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 404 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 404 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 405 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 405 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 406 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 406 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 407 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 407 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacaa aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 408 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 408 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 409 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 409 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 410 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 410 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 411 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 411 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagctg aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 412 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 412 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Leu Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 413 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 413 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaggtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 414 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 414 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 415 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 415 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accgttatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 416 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 416 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 417 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 417 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 418 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 418 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 419 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 419 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 420 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 420 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 421 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 421 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 422 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 422 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 423 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 423 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 424 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 424 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 425 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 425 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 426 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 426 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 427 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 427 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaaa aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 428 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 428 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 429 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 429 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttggc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 430 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 430 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gly Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 431 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 431 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacaa aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 432 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 432 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 433 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 433 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 434 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 434 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 435 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 435 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 436 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 436 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 437 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 437 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 438 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 438 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 439 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 439 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 440 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 440 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 441 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 441 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 442 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 442 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 443 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 443 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 444 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 444 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Glu Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 445 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 445 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 446 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 446 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 447 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 447 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 448 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 448 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 449 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 449 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 450 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 450 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 451 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 451 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 452 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 452 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 453 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 453 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 454 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 454 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 455 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 455 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 456 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 456 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 457 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 457 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 458 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 458 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 459 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 459 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaaa aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 460 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 460 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 461 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 461 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 462 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 462 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 463 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 463 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaaa aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 464 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 464 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 465 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 465 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 466 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 466 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 467 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 467 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacatcgt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 468 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 468 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 469 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 469 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 actgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 470 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 470 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Thr Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 471 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 471 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 472 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 472 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 473 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 473 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 474 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 474 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 475 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 475 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 476 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 476 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 477 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 477 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 478 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 478 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 479 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 479 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 480 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 480 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 481 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 481 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 482 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 482 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 483 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 483 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 484 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 484 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 485 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 485 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtga tcgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaca tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 486 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 486 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Asp Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys His Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 487 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 487 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc acgtgagaag aagatgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 488 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 488 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 489 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 489 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac ggtcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 490 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 490 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 491 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 491 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 492 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 492 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 493 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 493 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacaa aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga tggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 494 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 494 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 495 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 495 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 496 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 496 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 497 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 497 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 498 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 498 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 499 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 499 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagctg aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ccggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 500 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 500 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Leu Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Pro Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 501 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 501 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 502 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 502 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 503 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 503 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 504 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 504 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 505 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 505 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaggtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 506 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 506 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 507 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 507 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gattgagaag aaggtgctgg attatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaggatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accgttatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 508 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 508 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 509 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 509 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 510 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 510 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 511 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 511 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aaggtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta cgaagtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 512 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 512 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Glu Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 513 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 513 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggcgcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 514 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 514 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 515 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 515 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 516 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 516 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 517 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 517 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgttg gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatat aagcgtcgtc tgcgtaccac ctacctgggt 1200 agttatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 518 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 MCYP combi <400> 518 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Trp Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 519 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 519 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcgc gtgagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 520 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 520 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Arg Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 521 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 521 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aaggt 2355 <210> 522 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 522 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Gly 785 <210> 523 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 523 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttattgtgtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga ccagagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 524 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 524 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Cys Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gln Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 525 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 525 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac ccagctggat 2340 acctggctga aacgt 2355 <210> 526 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 526 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gln Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 527 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 527 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgagttac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 528 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 528 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ser Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 529 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 529 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtgcg 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 530 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 530 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Ala Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 531 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 531 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgatgtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 532 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 532 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Met Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 533 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 533 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga ccggagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 534 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 534 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Arg Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 535 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 535 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgcagtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctacg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 536 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 536 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Gln Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 537 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 537 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatccagat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 538 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 538 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Gln Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 539 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 539 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatggtagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 540 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 540 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gly Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 541 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 541 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcaatat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 542 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 542 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Asn Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 543 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 543 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaga tggcctggat 2340 acctggctga aacgt 2355 <210> 544 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 544 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Asp Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 545 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 545 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaaa gtgttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 546 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 546 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Ser 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 547 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 547 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgtttgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 548 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 548 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Phe Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 549 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 549 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattggg 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 550 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 550 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Gly Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 551 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 551 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcacgat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 552 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 552 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Thr Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 553 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 553 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgcgttac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 554 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 554 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Arg Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 555 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 555 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcgatgat 2340 acctggctga aacgt 2355 <210> 556 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 556 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Asp Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 557 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 557 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaagggcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 558 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 558 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Gly Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 559 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 559 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag tgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccgttaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 560 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 560 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Val Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 561 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 561 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaggct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cgacgctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 562 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 562 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Arg Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Thr Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 563 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 563 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaagtcg ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcaggagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 564 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 564 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Ser Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Gln Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 565 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 565 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgtat 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 566 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 566 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Tyr 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 567 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 567 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagtatgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 568 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 568 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Tyr 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 569 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 569 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtggct 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 570 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 570 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Ala 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 571 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 571 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcgtttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 572 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 572 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Val Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 573 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 573 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tgttctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 574 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 574 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Val Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 575 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 575 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat ggctgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 576 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 576 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Ala Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 577 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 577 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat ggtggataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 agggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 578 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 578 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Val Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Arg Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 579 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 579 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagaagatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggtgtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 580 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 580 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Glu Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Val Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 581 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 581 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgcagtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaca ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 582 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 582 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Gln Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Gln Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 583 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 583 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg gtaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 584 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 584 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Gly 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 585 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 585 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggcg 2340 acctggctga aacgt 2355 <210> 586 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 586 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Ala Thr Trp Leu Lys 770 775 780 Arg 785 <210> 587 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 587 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaagg ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 588 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 588 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Gly Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 589 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 589 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgct 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctgggaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 590 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 590 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Gly 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 591 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 591 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggggatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 592 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 592 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Gly Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 593 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 593 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtggaatgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 594 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 594 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asn Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 595 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 595 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacgat ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 596 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 596 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Asp Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 597 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 597 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caaggccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catggggaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 598 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 598 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Ala Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Gly Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 599 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 599 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt cgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc gttgatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 600 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 600 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Leu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 601 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 601 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 atttttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 602 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 602 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Ile Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 603 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 603 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatgc ggcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 604 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 604 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ala Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 605 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 605 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 atgtttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 606 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 606 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Met Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 607 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 607 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agagcagtac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 608 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 608 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Gln Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 609 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 609 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gggtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 610 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 610 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Gly Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 611 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 611 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtggcctgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 612 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 612 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Pro Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 613 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 613 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatct ggcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 614 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 614 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Leu Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 615 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 615 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtactgt 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 616 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 616 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 617 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 617 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaat gtgttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 618 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 618 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Cys 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 619 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 619 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gtttgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 620 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 620 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Phe Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 621 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 621 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gacctctaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 622 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 622 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ser Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 623 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 623 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ctgtttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca gcttaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 624 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 624 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Leu Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Leu Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 625 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 625 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctgtgg 2340 acctggctga aacgt 2355 <210> 626 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 626 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Trp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 627 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 627 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagcggaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 628 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 628 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Arg Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 629 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 629 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccgcctga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 630 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 630 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Pro Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 631 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 631 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catggagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 632 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 632 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Glu Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 633 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 633 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgtat gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagtgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 634 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 634 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Tyr Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 635 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 635 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaac tgacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 636 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 636 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Thr Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 637 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 637 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca ggccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 638 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 638 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Arg 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 639 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 639 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa acctaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 640 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 640 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Pro Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 641 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 641 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaagcat 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 642 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 642 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys His Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 643 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 643 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggtggt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 644 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 644 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Val Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 645 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 645 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacact ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 646 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 646 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Thr Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 647 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 647 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgct taagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 648 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 648 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Leu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 649 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 649 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgag gaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 650 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 650 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Arg Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 651 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 651 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caaggagaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 652 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 652 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Glu Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 653 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 653 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agctttctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 654 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 654 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Phe Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 655 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 655 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gtatgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 656 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 656 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Tyr Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 657 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 657 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacag tgaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 658 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 658 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Ser Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 659 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 659 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caaggctaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 660 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 660 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Ala Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 661 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 661 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tattcgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 662 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 662 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ile Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 663 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 663 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggctaggat 2340 acctggctga aacgt 2355 <210> 664 <211> 778 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 664 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly 770 775 <210> 665 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 665 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aaggcgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcgtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 666 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 666 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Gly Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 667 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 667 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgtggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaaggggctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 668 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 668 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Val Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 669 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 669 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aactggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 670 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 670 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Leu Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 671 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 671 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcgtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 672 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 672 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 673 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 673 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgacggagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 674 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 674 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Thr Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 675 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 675 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gtgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 676 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 676 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Cys Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 677 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 677 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gtctgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 678 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 678 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Ser Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 679 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 679 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgtctaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 680 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 680 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Ser Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 681 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 681 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaagcgat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 682 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 682 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Ala 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 683 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 683 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 accgtgctga aacgt 2355 <210> 684 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 684 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Val Leu Lys 770 775 780 Arg 785 <210> 685 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 685 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccggc taagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 686 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 686 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Ala Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 687 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 687 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgctt gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 688 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 688 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Leu Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 689 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 689 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccgggaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 690 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 690 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Gly Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 691 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 691 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gacccagaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 692 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 692 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Gln Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 693 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 693 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtactct ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 694 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 694 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Ser Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 695 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 695 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgc 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgtga actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 696 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 696 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Val Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 697 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 697 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactggtg ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 698 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 698 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Val Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 699 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 699 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggtgga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 700 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 700 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Val Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 701 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 701 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggaggctgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 702 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 702 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ala 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 703 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 703 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 gtttttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 704 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 704 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Val Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 705 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 705 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacat tgaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 706 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 706 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Ile Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 707 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 707 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagggag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 708 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 708 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Gly Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 709 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 709 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga ggtga 2355 <210> 710 <211> 784 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 710 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Arg 770 775 780 <210> 711 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 711 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gacccataag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 712 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 712 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr His Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 713 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 713 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agagcggtac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 714 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 714 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Arg Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 715 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 715 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gggagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 716 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 716 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Gly Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 717 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 717 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg cgagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt gagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 718 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 718 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Glu Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 719 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 719 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggactc gagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 720 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 720 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Ser Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 721 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 721 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagaggtgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 722 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 722 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Val Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 723 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 723 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagcagaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 724 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 724 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Gln Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 725 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 725 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga ccagagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 726 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 726 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gln Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 727 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 727 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttt aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggggga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 728 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 728 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Gly Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 729 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 729 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgtc taagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 730 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 730 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Ser Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 731 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 731 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgta taagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 732 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 732 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Tyr Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 733 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 733 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctctctga aacgt 2355 <210> 734 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 734 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Ser Leu Lys 770 775 780 Arg 785 <210> 735 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 735 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg catgagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 736 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 736 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu His Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 737 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 737 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgcataaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 738 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 738 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met His Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 739 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 739 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ctaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt acgataaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 740 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 740 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Asp Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 741 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 741 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacccttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc tgtagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 742 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 742 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Leu Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Cys Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 743 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 743 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaacagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 744 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 3 SNOCAPS <400> 744 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Gln Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 745 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 745 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgtaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagtttttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcattct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 acggaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 746 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 746 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Thr Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 747 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 747 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcattct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 748 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 748 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 749 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 749 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcttcctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagtttttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 750 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 750 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Phe Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 751 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 751 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggaggctttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcattct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag gacgtgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcgtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accgtcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 752 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 752 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Ala Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Asp Val Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 753 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 753 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacag aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcgcact gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccagtaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accgtcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 754 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 754 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ala Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ser Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Val Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 755 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 755 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcattct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aaatcgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 756 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 756 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Ser Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 757 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 757 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa accgaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagtttttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 758 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 758 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Pro Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 759 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 4 combis <400> 759 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 tgcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcttcctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 agctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcattct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 760 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 4 combis <400> 760 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Cys Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Phe Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Ser Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 761 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 761 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccac actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttggt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgtttgcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 762 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 762 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gly Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Phe Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 763 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 763 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 764 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 764 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 765 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 765 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 766 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 766 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 767 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 767 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggaggctttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacag aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttggt 1260 agcctgtatc cgcgcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcgcact gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagctg cctatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 768 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 768 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Ala Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gly Ser Leu Tyr Pro Arg Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ala Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Leu Pro Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 769 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 769 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 770 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 770 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 771 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 771 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa accgaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 772 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 772 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Pro Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 773 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 773 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcttcctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcctac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 774 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 774 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Phe Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 775 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 775 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 776 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 776 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 777 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 777 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtggcc 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcctac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 778 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 778 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Ala 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 779 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 779 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcctac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 780 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 780 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 781 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 781 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa accgaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccagtaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcctac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 782 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 782 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Pro Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ser Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 783 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 783 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtggcc 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcctac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 784 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 784 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Ala 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 785 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 785 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcctac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 786 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 786 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 787 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd 5 combis <400> 787 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcctac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 788 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd 5 combis <400> 788 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 789 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 789 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcag 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 790 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 790 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 791 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 791 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgcttgcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 792 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 792 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 793 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 793 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 tctgaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgatgtg 1980 gttgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgacccgtg gtatcaaagt gaagccgggc accatcatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 794 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd1 Fidelity SNOCAPS <400> 794 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Ser Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 795 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 795 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 796 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 796 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 797 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 797 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aaggttctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 798 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 798 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Val Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 799 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 799 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gcgggagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 800 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 800 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 801 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 801 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgata acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagt 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agtggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccag attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 802 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 802 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 803 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 803 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag gatatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 804 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 804 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Asp Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 805 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 805 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagtat aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 806 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 806 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Tyr Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 807 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 807 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 808 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 808 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 809 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 809 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aatcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag cagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacgcgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 810 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 810 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Asn Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Gln Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 811 <211> 2361 <212> DNA <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 811 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac gacaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgata acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagt 1080 atgaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agtctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gagatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaagtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tgaaagatta taaggcgatt ggcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 cgtggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga ggttcacaag 2220 tatgacgcag attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gcgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgttaatg a 2361 <210> 812 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd2 Fidelity SNOCAPS <400> 812 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Asp Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Met Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp Tyr Lys 675 680 685 Ala Ile Gly Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Arg Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Val His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 813 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 813 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caagaaaaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattcag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 814 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd3 Fidelity SNOCAPS <400> 814 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Lys Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Gln Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 815 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 815 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 816 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 816 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 817 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 817 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgtttgcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 818 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 818 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Phe Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 819 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 819 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aagcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgcaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 820 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 820 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Gln Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 821 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 821 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 atcaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaacag gggcgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat cctgcctaag 1440 atgaaggcga ccattgaccc gatcgagaag aagatgctgg attaccgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgaaagcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgaggtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agcccgcacg tgagcatcgc gaaacgtctg 2100 gcgactcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 822 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd5 Fidelity combi <400> 822 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Gln Gly Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Leu Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met Leu Asp Tyr Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Glu Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Thr Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 823 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 823 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 824 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 824 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 825 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 825 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctggcgtac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 826 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> DNA polymerase variant <400> 826 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Ala Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 827 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 827 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcgggt 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 828 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 828 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Gly 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 829 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 829 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggcaga aacgt 2355 <210> 830 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 830 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Gln Lys 770 775 780 Arg 785 <210> 831 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 831 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatgt ggcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 832 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 832 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Val Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 833 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 833 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaaggg tgagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 834 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 834 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Gly Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 835 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 835 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagactatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 836 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 836 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Thr Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 837 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 837 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aagcagcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 838 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 838 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Gln Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 839 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 839 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg acgaaaagcc ggagatcatt aaaggtaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 840 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 840 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Asp Glu Lys Pro Glu Ile Ile Lys Gly Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 841 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 841 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaacgct 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 842 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 842 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Ala Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 843 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 843 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagacgatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 844 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 844 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Thr Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 845 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 845 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggcgga aacgt 2355 <210> 846 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 846 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Arg Lys 770 775 780 Arg 785 <210> 847 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 847 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggattc tgaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 848 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 848 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Ser Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 849 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 849 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacagtacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 850 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 850 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ser Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 851 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 851 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gctattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 852 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 852 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Ala Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 853 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 853 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctgtt taagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 854 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 854 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Phe Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 855 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 855 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggaggggatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 856 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 856 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Gly Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 857 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 857 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttaggaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 858 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 858 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Arg Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 859 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 859 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tgtggacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 860 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 860 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 861 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 861 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagaa tcgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 862 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 862 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Asn Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 863 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 863 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagcttatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 864 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 864 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 865 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 865 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaaa gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 866 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 866 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Lys Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 867 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 867 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccggtg gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 868 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 868 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Val Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 869 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 869 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg aatgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 870 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 870 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Asn Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 871 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 871 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctggttta ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 872 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 872 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Phe Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 873 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 873 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtcgctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 874 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 874 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Ser Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 875 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 875 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacgggccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 876 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 876 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Gly Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 877 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 877 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagccgg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 878 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 878 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Pro Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 879 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 879 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccagcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgaggcgg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 880 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 880 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Ala Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 881 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 881 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattctgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 882 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 882 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Leu Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 883 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 883 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg gctgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 884 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 884 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Ala Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 885 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 885 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattctgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 886 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 886 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Leu Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 887 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 887 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagcaggc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 888 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 888 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Arg Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 889 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 889 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 cggattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 890 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 890 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Arg Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 891 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 891 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 ccgttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 892 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 892 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Pro Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 893 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 893 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacccggta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 894 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 894 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Arg Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 895 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 895 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 gtggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 896 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 896 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Val Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 897 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 897 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 atttttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 898 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 898 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Ile Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 899 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 899 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc tatagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 900 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 900 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Tyr Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 901 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 901 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccgtgcgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 902 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 902 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Val Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 903 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 903 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggagg tggaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 904 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 904 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Val Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 905 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 905 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga ctttagcgtt gaaaaggcgg tggagattgt tcgtgacgtt 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 906 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 906 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Phe Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 907 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 907 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggccatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 908 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 908 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly His Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 909 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 909 atgcatcacc atcaccatca cggtggcagc ggtatgattc tgtggaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 910 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 910 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Trp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 911 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 911 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcatgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 912 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 912 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala His Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 913 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 913 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg gggaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 914 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 914 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Gly Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 915 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 915 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagac gcgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 916 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 916 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Thr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 917 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 917 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 gggggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 918 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 918 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Gly Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 919 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 919 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gctggatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 920 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 920 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Leu Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 921 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 921 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgaggggg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 922 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 922 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Gly Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 923 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 923 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt accagatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 924 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 924 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Gln Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 925 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 925 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg acggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 926 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 926 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Thr Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 927 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 927 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgc ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 928 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 928 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Leu Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 929 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 929 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgg ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 930 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 930 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Val Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 931 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 931 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagcagg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 932 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 932 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Gln Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 933 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 933 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg cataaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 934 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 934 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu His Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 935 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 935 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccaccaag 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 936 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 936 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Lys Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 937 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 937 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctggcgggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 938 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 938 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Ala Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 939 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 939 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagtggg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 940 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 940 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Trp Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 941 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 941 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctga ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 942 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 942 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Ile Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 943 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 943 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 gggggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 944 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 944 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Gly Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 945 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 945 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgtg gaacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 946 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 946 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Trp Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 947 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 947 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagtggg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 948 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 948 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Trp Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 949 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 949 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 acggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 950 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 950 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Thr Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 951 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 951 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggaa agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagaagg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 952 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 952 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Lys Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 953 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 953 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaatggctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 954 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 954 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Trp Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 955 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 955 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaacatt 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 956 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 956 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Ile Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 957 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 957 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacct tgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 958 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 958 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Leu Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 959 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 959 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatcagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 960 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 960 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Gln Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 961 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 961 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca gtgtgttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 962 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 962 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Cys 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 963 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 963 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 aggattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 964 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 964 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Arg Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 965 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 965 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagac gatgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 966 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 966 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Thr Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 967 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 967 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtttgaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 968 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 968 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Leu Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 969 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 969 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccctgcgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 970 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 970 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Leu Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 971 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 971 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atggtggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 972 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 972 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Val Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 973 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 973 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgatgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 974 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 974 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Met Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 975 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 975 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttcgga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 976 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 976 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Arg Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 977 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 977 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagcg tatgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 978 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 978 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Arg Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 979 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 979 atgcatcacc atcaccatca cggtggcagc ggtatgactc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 980 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 980 Met His His His His His His Gly Gly Ser Gly Met Thr Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 981 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 981 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt accagatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 982 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 982 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Gln Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 983 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 983 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 tcgggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 984 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 984 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Ser Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 985 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 985 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatgc tgaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 986 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 986 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Ala Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 987 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 987 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagcc gatgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 988 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 988 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Pro Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 989 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 989 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatagtagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 990 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 990 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Ser Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 991 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 991 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagcc tatgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 992 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 992 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Pro Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 993 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 993 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tgtgctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 994 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 994 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Val Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 995 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 995 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcataccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 996 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 996 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu His Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 997 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 997 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag gtgaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 998 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 998 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Val Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 999 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 999 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtg gtcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1000 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1000 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Gly Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1001 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1001 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtactgc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1002 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1002 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1003 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1003 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcaagga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1004 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1004 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Lys Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1005 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1005 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggggaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1006 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1006 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Gly Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1007 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1007 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac caggctggat 2340 acctggctga aacgt 2355 <210> 1008 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1008 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Arg Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1009 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1009 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agagggtcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1010 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1010 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Gly Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1011 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1011 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac ccctctggat 2340 acctggctga aacgt 2355 <210> 1012 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1012 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Pro Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1013 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1013 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagcc ggaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1014 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1014 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Arg Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1015 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1015 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aaaaggatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1016 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1016 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Lys Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1017 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1017 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttgcgaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1018 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1018 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ala Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1019 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1019 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatagtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1020 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1020 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Ser 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1021 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1021 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgc aggaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1022 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1022 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gln Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1023 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1023 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gcctctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1024 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1024 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Pro Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1025 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1025 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctgcttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1026 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1026 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Leu Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1027 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1027 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctgg agcgt 2355 <210> 1028 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1028 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Glu 770 775 780 Arg 785 <210> 1029 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1029 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaagg gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1030 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1030 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Gly Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1031 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1031 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 cggggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1032 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1032 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Arg Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1033 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1033 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgtgggagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1034 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1034 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Trp Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1035 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1035 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaaattatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1036 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1036 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Ile Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1037 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1037 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgtcgat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1038 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1038 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ser Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1039 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1039 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgctg agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1040 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1040 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Leu Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1041 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1041 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gctttcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1042 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1042 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Phe Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1043 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1043 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aacctgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1044 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1044 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Pro Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1045 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1045 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcctgctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1046 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1046 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Leu Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1047 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1047 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgaccaggg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1048 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1048 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Arg Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1049 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1049 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggcgtctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1050 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1050 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Arg Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1051 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1051 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc ctgacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcgggcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1052 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1052 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Gly Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1053 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1053 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gtctgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1054 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1054 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Ser Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1055 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1055 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc ggcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1056 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1056 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Arg Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1057 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1057 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgtgggagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1058 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1058 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Trp Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1059 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1059 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaatgc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1060 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1060 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Met Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1061 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1061 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gcgggatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1062 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1062 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Arg Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1063 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1063 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcacgattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1064 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1064 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Thr Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1065 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1065 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag gcgaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1066 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6 Diversity <400> 1066 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ala Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1067 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1067 atgcatcacc atcaccatca cggtggcagc ggtatgattc tgtggaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagtttg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatgt tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaccgaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc tgagactatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcttccaaac cgggctggat 2340 acctggcagg agcgt 2355 <210> 1068 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1068 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Trp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Val Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Thr Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Phe Gln Thr Gly Leu Asp Thr Trp Gln Glu 770 775 780 Arg 785 <210> 1069 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1069 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gagggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagtttg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcccgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggagg tcgaagagtc gatgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatgt tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc tgagactatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cgggctggat 2340 acctggcagg agcgt 2355 <210> 1070 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1070 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Val Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Val Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Thr Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Gln Glu 770 775 780 Arg 785 <210> 1071 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1071 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggataccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagtttg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcccgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc tgagactatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1072 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1072 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Thr Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1073 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1073 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aagcaacgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagtttg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctgctgctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaccgaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc tgagctgatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1074 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1074 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Gln Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Leu Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1075 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1075 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggtgctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctggttca ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc ggagatcatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1076 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1076 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Phe Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1077 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1077 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagtttg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaaa gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaagcc tgagattatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagaa ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1078 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1078 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Lys Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Pro Glu Ile Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Asn Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1079 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1079 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aagcaacgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagtaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccggtt gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaaccgaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaaggg tgaggggatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagta ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1080 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1080 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Gln Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Val Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Gly Glu Gly Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1081 <211> 2355 <212> DNA <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1081 atgcatcacc atcaccatca cggtggcagc ggtatgattc tggacaccga ttacatcacc 60 aaagatggca agccgatcat tcgtattttc aagaaagaaa acggcgagtt taagatcgag 120 ctggacccgc actttcagcc gtacatttat gcgctgctga aagacgatag cgcgatcgag 180 gaaattaaag cgatcaaggg tgaacgtcac ggcaaaaccg tgcgtgttct ggacgcggtg 240 aaggttcgta agaaattcct gggtcgtgag gtggaagttt ggaagctgat ctttgagcac 300 ccgcaagacg tgccggcgat gcgtgataag attaaagaac acccggcggt tatcgacatt 360 tacgagtatg atatcccgtt tgcgaaacgt tacctgattg acaagggtct gatcccgatg 420 gaaggcgatg aggaactgaa gctgctggcg ttcgacattg agacctttta ccacgaaggt 480 gatgagttcg gtaaaggcga aatcattatg atcagctatg cggacgagga agaggcgcgt 540 gtgattacct ggaagaacat cgacctgccg tacgttgatg tggttagcaa cgagcgtgaa 600 atgatcaaac gttttgtgca ggtggttaag gagaaagacc cggatgttat cattacctac 660 aacggcgaca acttcgatct gccgtatctg atcaaacgtg cggaaaagct gggtgtgcgt 720 ctggttctgg gccgtgacaa agaaaacccg gagccgaaga tccaacgtat gggtgatagc 780 ttcgcggtgg agattaaagg ccgtatccac ttcgacctgt ttccggtggt tcgtcgtacc 840 attaacctgc cgacctacac cctggaagcg gtgtatgagg cggttctggg caagaccaaa 900 agcaagctgg gcgcggaaga gattgcggcg atctgggaga ccgaagagag catgaagaaa 960 ctggcgcagt acagcatgga agatgcgcgt gcgacctatg aactgggcaa ggagttcttt 1020 ccgatggagg cggaactggc gaaactgatc ggtcaaagcg tgtgggacgt tagccgtagc 1080 agcaccggca acctggtgga atggtacctg ctgcgtgttg cgtatgcgcg taacgagctg 1140 gcgccgaaca aaccggatga agaggaatac aaacgtcgtc tgcgtaccac ctacctgggt 1200 ggctatgtga aagagccgga aaagggtctg tgggagaaca tcatttacct ggactttcgt 1260 agcctgtatc cgagcatcat tgtgacccac aacgttagcc cggacaccct ggagaaggaa 1320 ggctgcgaaa actacgatat tgcgccgatc gttagctatc gtttctgcaa agacttcccg 1380 ggttttattc cgagcatcct gggcgatctg attgcgatgc gtcaggagat caaacctaag 1440 atgaaggcga ccattgaccc gcgtgagaag aagatgctgg ataatcgtca acgtgcggtt 1500 aaactgctgg cgaacagcta ctatggttac atgggctatc cgctggcgcg ttggtacagc 1560 aaggaatgcg cggagagcgt gaccgcgtgg ggtcgtcact atatcgaaat gaccattaag 1620 gagatcgagg aaaaattcgg ctttaaggtt ctgtacgcgg acaccgatgg tttctatgcg 1680 accattccgg gcgaaaaggg tgaggggatt aaaaagaaag cgcgtgagtt tctgaactac 1740 atcaacagca aactgccggg tctgctggag ctggaatacg agggtttcta tctgcgtggc 1800 ttctttgtga ccaagaaacg ttatgcggtt attgatgagg aaggtcgtat caccacccgt 1860 ggtctggaag tggttcgtcg tgactggagc gaaatcgcga aagagaccca ggcgaaggtg 1920 ctggaagcga ttctgaaaga cggtagcgtt gaaaaggcgg tggagattgt tcgtgacgtg 1980 gtcgaaaaaa tcgcgaagaa ccgtgtgccg ctggaaaagc tggttattca cgagcaaatc 2040 acccgtgacc tggatgatta taaggcgatt agtccgcacg tgagcatcgc gaaacgtctg 2100 gcggctcgtg gtatcaaagt gaagccgggc accattatta gctacctggt tctgaaaggt 2160 agcggcaaga ttagcgaccg tgttatcctg ctgaccgaat acgatccgga gaaacacaag 2220 tatgacccgg attactatat cgagaaccag gtgctgccgg cggttctgcg tattctggaa 2280 gctttcggtt accgtaaaga ggacctgcgt tatcagagca gcaagcaaac cggcctggat 2340 acctggctga aacgt 2355 <210> 1082 <211> 785 <212> PRT <213> Artificial Sequence <220> <223> Rd6B Diversity <400> 1082 Met His His His His His His Gly Gly Ser Gly Met Ile Leu Asp Thr 1 5 10 15 Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile Arg Ile Phe Lys Lys 20 25 30 Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro His Phe Gln Pro Tyr 35 40 45 Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile Glu Glu Ile Lys Ala 50 55 60 Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg Val Leu Asp Ala Val 65 70 75 80 Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val Glu Val Trp Lys Leu 85 90 95 Ile Phe Glu His Pro Gln Asp Val Pro Ala Met Arg Asp Lys Ile Lys 100 105 110 Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr Asp Ile Pro Phe Ala 115 120 125 Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro Met Glu Gly Asp Glu 130 135 140 Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr Phe Tyr His Glu Gly 145 150 155 160 Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile Ser Tyr Ala Asp Glu 165 170 175 Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile Asp Leu Pro Tyr Val 180 185 190 Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys Arg Phe Val Gln Val 195 200 205 Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr Tyr Asn Gly Asp Asn 210 215 220 Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu Lys Leu Gly Val Arg 225 230 235 240 Leu Val Leu Gly Arg Asp Lys Glu Asn Pro Glu Pro Lys Ile Gln Arg 245 250 255 Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly Arg Ile His Phe Asp 260 265 270 Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu Pro Thr Tyr Thr Leu 275 280 285 Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr Lys Ser Lys Leu Gly 290 295 300 Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu Glu Ser Met Lys Lys 305 310 315 320 Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala Thr Tyr Glu Leu Gly 325 330 335 Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala Lys Leu Ile Gly Gln 340 345 350 Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu Val Glu Trp 355 360 365 Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala Pro Asn Lys 370 375 380 Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr Tyr Leu Gly 385 390 395 400 Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile Ile Tyr 405 410 415 Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His Asn Val 420 425 430 Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Glu Asn Tyr Asp Ile Ala 435 440 445 Pro Ile Val Ser Tyr Arg Phe Cys Lys Asp Phe Pro Gly Phe Ile Pro 450 455 460 Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Glu Ile Lys Pro Lys 465 470 475 480 Met Lys Ala Thr Ile Asp Pro Arg Glu Lys Lys Met Leu Asp Asn Arg 485 490 495 Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly 500 505 510 Tyr Pro Leu Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu Ser Val Thr 515 520 525 Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys Glu Ile Glu Glu 530 535 540 Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe Tyr Ala 545 550 555 560 Thr Ile Pro Gly Glu Lys Gly Glu Gly Ile Lys Lys Lys Ala Arg Glu 565 570 575 Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu Glu Leu Glu 580 585 590 Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr Lys Lys Arg Tyr 595 600 605 Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg Gly Leu Glu Val 610 615 620 Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Lys Val 625 630 635 640 Leu Glu Ala Ile Leu Lys Asp Gly Ser Val Glu Lys Ala Val Glu Ile 645 650 655 Val Arg Asp Val Val Glu Lys Ile Ala Lys Asn Arg Val Pro Leu Glu 660 665 670 Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Asp Asp Tyr Lys 675 680 685 Ala Ile Ser Pro His Val Ser Ile Ala Lys Arg Leu Ala Ala Arg Gly 690 695 700 Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Leu Val Leu Lys Gly 705 710 715 720 Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr Glu Tyr Asp Pro 725 730 735 Glu Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu Asn Gln Val Leu 740 745 750 Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg Lys Glu Asp 755 760 765 Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp Thr Trp Leu Lys 770 775 780 Arg 785 <210> 1083 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Synthetic DNA <400> 1083 aggaggactc cttatgtcca aa 22 <210> 1084 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Synthetic DNA <400> 1084 tcgtttacac aagtcaagtc tg 22 <210> 1085 <211> 7976 <212> DNA <213> Artificial Sequence <220> <223> Synthetic DNA <400> 1085 aggaggactc cttatgtcca aatttaattg ataatggaag ctggccagcc accaccacac 60 agaattctgt agctttgaag aatgcaggtt taatatccac tttgaaaaag aaaacaaata 120 agtttattta tgctatacat gatgaaacat cttataaagg aaaaaaaata ccgaaagacc 180 aaaaatcaga actaattaac tgttcagccc agtttgaagc aaatgctttt gaagcaccac 240 ttacatttgc aaatgctgat tcaggtacct ctgtcttttt ttttttgtaa atagtacata 300 tagttttata gatgacgatt ccttctgtgt ttttttctgc tttttaaaat cttcatatct 360 tatatttaat cttaggcatc atctgtatac atgattgttt aggtctttaa ttaccagtgt 420 ttagaatcag gtcactcaaa catggtagat aagtttgcat agtttgtgta tatccatcac 480 tcttgagaca gttttatttt aagttccggg gtacatgtgc aggatgtgca ggtttgttac 540 ataagtaaac gtatgccatg ttggtttgct gcacctgtca acccttcacc tgagtattaa 600 gcccagcatg cattagctat ttttcctggt gctctccttc cccccacaca cccccacctc 660 ctgacagacc ctagtgtgtg ttgttcccct ccctgtgtcc gtgtgttctc attgttcagc 720 tcccacttat gagtgagaac atgtgatgtt tagttttctg ttcctgcatt agtttgctta 780 ggataatggc ttccagctcc atctgtgtcc ctgcaaagga cgtgatcttg ttccttttta 840 tggctacatg gtattccatg gtgtatagtt ccacatttta tttatccagt ctatcattga 900 tgggcatttg ggttgattcc atgtctgtgc tattgtgaat agtgctgcag tgaatgtaca 960 ggtggatgta tctttataat acaatgattt atcttccttt gggtatatac cccgtaatgg 1020 gattgctgag tcagatggta tttttggttc taggtctttg aggaattgcc acactgtctt 1080 ccacaacggt tgaactaatt tacattccag ccaacaactt gagacagttt ttgactcata 1140 aacattcaga gcttggctag ctaattcctg ctttaattta aaaagtgttt attatatgca 1200 aattggacaa ctcatataaa tatgtggtgc tacttactat gtattttctc taaagcatgt 1260 taaaaaaata ggctagatat agtggctcat gcctgtaatc ttagcacttt gggaggctaa 1320 ggcaggagga tcacttatgg tcaggagttt aagaacaccc tgggcaacat agcgagaccc 1380 catctctaca aaaaatttaa aatacccagg catggtggca tgcttctgat gttgtagcta 1440 ctcaggatgc tcagacagga ggatcacttg agcccaagtg actgaggctg cagtgaacca 1500 aaattgtacc agtgcactcc agcctgggcc acaaaatgag accttgtccc tgaaaaaaaa 1560 aaaagaaaaa aaaaatttaa atagaggaaa tactagctaa gtttaatgta ggccagttct 1620 aaaataatga tttattgctg ctgttgttac ataattttct taaatatttt aaagattgca 1680 tactgttact gctctatttc tgcatctccg tggtgtaact ctgtcctctt tgttgttgca 1740 acagttcact tagcaactaa actgtatgtt tacaaagtga ttttatctcc ctatgagaag 1800 actttagtga atagctcagt gaatagtaga gttggtgaga ccacagtaca gaactgtttg 1860 aagtttgggt taaattttta gaggaaaatg tttgatacta tgcatatcat agttaaagcc 1920 aatgaaaaag ctaatatagg ccaggcgcag tggctcacgc ctataatccc agcactttgg 1980 gaggccaagg caggcagatc acttaaggtc aagagttcaa gaccagcctg gccaacatgg 2040 taaaacccca tctctatgaa aaaaaacaaa aattatccag atgtggtggc atgtgcctgt 2100 aatcccagct actcgggacg ctaaggcagg agaatcactt gaacctggga gatggaggtt 2160 gcaatgagct gagatcacgc cactgcactc cagcctgggt gacagaacga gactccatct 2220 caaaaaaaaa aaaaaaaaaa gctaatacat gtgatcactg atgaaatgca attaagaact 2280 ggttagtaga aaattcagag ggtcaagaaa tttaacagag cagttgaact catttgcctt 2340 tatcgttgag attagatcat ctttcaggct gttagtatat ggaccctgtt tttaaaaatt 2400 gtggttttgt ttttttcaat gtgaaagaat taagaaaatt gttacttttc taattccttt 2460 tctgtgcctt gcttttctgt tcacaccagt attaacagca atgaaatttt ttcaatttta 2520 ttttccaata aaaattactt tgagtttttt ttatggtagc tagctacttc cttgacctag 2580 atactaattt tgattgagtt ggtaactatt attaaaaaaa caacttaggt ctaatttatc 2640 ttgagctaaa aaatgtaata actgaaaaat agagcatatt taggattctt tctgctttaa 2700 atttgacatt cagttatttt catgtaattt gtgttttgag cactaccttt taattaattt 2760 atttattttt attttttaga gactgtctca ttctgttacc tagtctggag tgcactagtg 2820 tgatctcagc tcaccgtagc ctcaccctcc tgggctcaag cagtccttgc acctcaccct 2880 cctgagtaac tggcaccaca ggcatacacc accacaccca gctaattttt atttttcata 2940 gagtcatggt ctcactatgt tgcccaggct agtctcgaac tcctgggctc aagcagtctt 3000 cctgcctcag cctcccaaaa gtgctgagat tacaggcatg agccactgtg cccaaacact 3060 acctttttaa cttagtgaaa aatatttagt gaatgtgatt gatggtactt taattttgtc 3120 actttgtgtt tttatgttta ggtttattgc attcttctgt gaaaagaagc tgttcacaga 3180 atgattctga agaaccaact ttgtccttaa ctagctcttt tgggacaatt ctgaggaaat 3240 gttctagaaa tgaaacatgt tctaataata cagtaatctc tcaggatctt gattataaag 3300 aagcaaaatg taataaggaa aaactacagt tatttattac cccagaagct gattctctgt 3360 catgcctgca ggaaggacag tgtgaaaatg atccaaaaag caaaaaagtt tcagatataa 3420 aagaagaggt cttggctgca gcatgtcacc cagtacaaca ttcaaaagtg gaatacagtg 3480 atactgactt tcaatcccag aaaagtcttt tatatgatca tgaaaatgcc agcactctta 3540 ttttaactcc tacttccaag gatgttctgt caaacctagt catgatttct agaggcaaag 3600 aatcatacaa aatgtcagac aagctcaaag gtaacaatta tgaatctgat gttgaattaa 3660 ccaaaaatat tcccatggaa aagaatcaag atgtatgtgc tttaaatgaa aattataaaa 3720 acgttgagct gttgccacct gaaaaataca tgagagtagc atcaccttca agaaaggtac 3780 aattcaacca aaacacaaat ctaagagtaa tccaaaaaaa tcaagaagaa actacttcaa 3840 tttcaaaaat aactgtcaat ccagactctg aagaactttt ctcagacaat gagaataatt 3900 ttgtcttcca agtagctaat gaaaggaata atcttgcttt aggaaatact aaggaacttc 3960 atgaaacaga cttgacttgt gtaaacgatc ctcctgagga atacaggttt aaattaacta 4020 ttaccttcga ccggtcggtg gtggtgtgtc ttaagacatc gaaacttctt acgtccaaat 4080 tataggtgaa actttttctt ttgtttattc aaataaatac gatatgtact actttgtaga 4140 atatttcctt ttttttatgg ctttctggtt tttagtcttg attaattgac aagtcgggtc 4200 aaacttcgtt tacgaaaact tcgtggtgaa tgtaaacgtt tacgactaag tccatggaga 4260 cagaaaaaaa aaaacattta tcatgtatat caaaatatct actgctaagg aagacacaaa 4320 aaaagacgaa aaattttaga agtatagaat ataaattaga atccgtagta gacatatgta 4380 ctaacaaatc cagaaattaa tggtcacaaa tcttagtcca gtgagtttgt accatctatt 4440 caaacgtatc aaacacatat aggtagtgag aactctgtca aaataaaatt caaggcccca 4500 tgtacacgtc ctacacgtcc aaacaatgta ttcatttgca tacggtacaa ccaaacgacg 4560 tggacagttg ggaagtggac tcataattcg ggtcgtacgt aatcgataaa aaggaccacg 4620 agaggaaggg gggtgtgtgg gggtggagga ctgtctggga tcacacacaa caaggggagg 4680 gacacaggca cacaagagta acaagtcgag ggtgaatact cactcttgta cactacaaat 4740 caaaagacaa ggacgtaatc aaacgaatcc tattaccgaa ggtcgaggta gacacaggga 4800 cgtttcctgc actagaacaa ggaaaaatac cgatgtacca taaggtacca catatcaagg 4860 tgtaaaataa ataggtcaga tagtaactac ccgtaaaccc aactaaggta cagacacgat 4920 aacacttatc acgacgtcac ttacatgtcc acctacatag aaatattatg ttactaaata 4980 gaaggaaacc catatatggg gcattaccct aacgactcag tctaccataa aaaccaagat 5040 ccagaaactc cttaacggtg tgacagaagg tgttgccaac ttgattaaat gtaaggtcgg 5100 ttgttgaact ctgtcaaaaa ctgagtattt gtaagtctcg aaccgatcga ttaaggacga 5160 aattaaattt ttcacaaata atatacgttt aacctgttga gtatatttat acaccacgat 5220 gaatgataca taaaagagat ttcgtacaat ttttttatcc gatctatatc accgagtacg 5280 gacattagaa tcgtgaaacc ctccgattcc gtcctcctag tgaataccag tcctcaaatt 5340 cttgtgggac ccgttgtatc gctctggggt agagatgttt tttaaatttt atgggtccgt 5400 accaccgtac gaagactaca acatcgatga gtcctacgag tctgtcctcc tagtgaactc 5460 gggttcactg actccgacgt cacttggttt taacatggtc acgtgaggtc ggacccggtg 5520 ttttactctg gaacagggac tttttttttt ttcttttttt tttaaattta tctcctttat 5580 gatcgattca aattacatcc ggtcaagatt ttattactaa ataacgacga caacaatgta 5640 ttaaaagaat ttataaaatt tctaacgtat gacaatgacg agataaagac gtagaggcac 5700 cacattgaga caggagaaac aacaacgttg tcaagtgaat cgttgatttg acatacaaat 5760 gtttcactaa aatagaggga tactcttctg aaatcactta tcgagtcact tatcatctca 5820 accactctgg tgtcatgtct tgacaaactt caaacccaat ttaaaaatct ccttttacaa 5880 actatgatac gtatagtatc aatttcggtt actttttcga ttatatccgg tccgcgtcac 5940 cgagtgcgga tattagggtc gtgaaaccct ccggttccgt ccgtctagtg aattccagtt 6000 ctcaagttct ggtcggaccg gttgtaccat tttggggtag agatactttt ttttgttttt 6060 aataggtcta caccaccgta cacggacatt agggtcgatg agccctgcga ttccgtcctc 6120 ttagtgaact tggaccctct acctccaacg ttactcgact ctagtgcggt gacgtgaggt 6180 cggacccact gtcttgctct gaggtagagt tttttttttt ttttttttcg attatgtaca 6240 ctagtgacta ctttacgtta attcttgacc aatcatcttt taagtctccc agttctttaa 6300 attgtctcgt caacttgagt aaacggaaat agcaactcta atctagtaga aagtccgaca 6360 atcatatacc tgggacaaaa atttttaaca ccaaaacaaa aaaagttaca ctttcttaat 6420 tcttttaaca atgaaaagat taaggaaaag acacggaacg aaaagacaag tgtggtcata 6480 attgtcgtta ctttaaaaaa gttaaaataa aaggttattt ttaatgaaac tcaaaaaaaa 6540 taccatcgat cgatgaagga actggatcta tgattaaaac taactcaacc attgataata 6600 atttttttgt tgaatccaga ttaaatagaa ctcgattttt tacattattg actttttatc 6660 tcgtataaat cctaagaaag acgaaattta aactgtaagt caataaaagt acattaaaca 6720 caaaactcgt gatggaaaat taattaaata aataaaaata aaaaatctct gacagagtaa 6780 gacaatggat cagacctcac gtgatcacac tagagtcgag tggcatcgga gtgggaggac 6840 ccgagttcgt caggaacgtg gagtgggagg actcattgac cgtggtgtcc gtatgtggtg 6900 gtgtgggtcg attaaaaata aaaagtatct cagtaccaga gtgatacaac gggtccgatc 6960 agagcttgag gacccgagtt cgtcagaagg acggagtcgg agggttttca cgactctaat 7020 gtccgtactc ggtgacacgg gtttgtgatg gaaaaattga atcacttttt ataaatcact 7080 tacactaact accatgaaat taaaacagtg aaacacaaaa atacaaatcc aaataacgta 7140 agaagacact tttcttcgac aagtgtctta ctaagacttc ttggttgaaa caggaattga 7200 tcgagaaaac cctgttaaga ctcctttaca agatctttac tttgtacaag attattatgt 7260 cattagagag tcctagaact aatatttctt cgttttacat tattcctttt tgatgtcaat 7320 aaataatggg gtcttcgact aagagacagt acggacgtcc ttcctgtcac acttttacta 7380 ggtttttcgt tttttcaaag tctatatttt cttctccaga accgacgtcg tacagtgggt 7440 catgttgtaa gttttcacct tatgtcacta tgactgaaag ttagggtctt ttcagaaaat 7500 atactagtac ttttacggtc gtgagaataa aattgaggat gaaggttcct acaagacagt 7560 ttggatcagt actaaagatc tccgtttctt agtatgtttt acagtctgtt cgagtttcca 7620 ttgttaatac ttagactaca acttaattgg tttttataag ggtacctttt cttagttcta 7680 catacacgaa atttactttt aatatttttg caactcgaca acggtggact ttttatgtac 7740 tctcatcgta gtggaagttc tttccatgtt aagttggttt tgtgtttaga ttctcattag 7800 gtttttttag ttcttctttg atgaagttaa agtttttatt gacagttagg tctgagactt 7860 cttgaaaaga gtctgttact cttattaaaa cagaaggttc atcgattact ttccttatta 7920 gaacgaaatc ctttatgatt ccttgaagta ctttgtctga actgaacaca tttgct 7976

Claims (47)

  1. 서열번호 2, 6, 22, 24, 26, 28 및/또는 824의 참조 서열과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 서열 동일성을 갖는 폴리펩티드 서열 또는 이의 기능적 단편을 포함하는 조작된 DNA 중합효소로서, 조작된 DNA 중합효소는 그의 폴리펩티드 서열에 적어도 하나의 돌연변이를 포함하며, 폴리펩티드 서열의 아미노산 위치가 서열번호 2, 6, 22, 24, 26, 28 또는 824를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  2. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00065

    및/또는 이들의 임의의 조합으로부터 선택되며, 아미노산 위치는 서열번호 6을 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  3. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00066

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 6을 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  4. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00067

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 22를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  5. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가 100, 277, 280, 281, 283, 339, 401, 468, 479, 480, 482, 489, 490, 491, 496, 497 및 498, 및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 22를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  6. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00068

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 24를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  7. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00069

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 24를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  8. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가 248, 281, 281/302, 281/492, 302/401, 339/491/492/579/712, 390/466/539/712 및 661, 및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 26을 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  9. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00070

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 28을 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  10. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가 257, 420, 515 및 521, 및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 6을 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  11. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00071

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 22를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  12. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가 240, 370, 385, 539, 540, 550/575, 634 및 777, 및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 24를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  13. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가 390/391, 482 및 515, 및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 28을 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  14. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가 281, 281/579, 및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 28을 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  15. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00072

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 824를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  16. 제1항에 있어서, 적어도 하나의 치환 또는 치환 세트가
    Figure pct00073

    및/또는 이들의 임의의 조합으로부터 선택된 아미노산 위치에서의 치환을 포함하며, 아미노산 위치는 서열번호 824를 참조하여 넘버링되는 것인 조작된 DNA 중합효소.
  17. 제1항에 있어서, 표 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.1, 4.2, 4.3, 4.4, 4.5, 6.2 및/또는 6.3에 제시된 적어도 하나의 조작된 DNA 중합효소 변이체의 서열과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상 동일한 폴리펩티드 서열을 포함하는 조작된 DNA 중합효소.
  18. 제1항 내지 제17항 중 어느 한 항에 있어서, DNA 중합효소 활성을 갖는 조작된 DNA 중합효소.
  19. 제1항 내지 제18항 중 어느 한 항에 있어서, 피로코쿠스 퓨리오수스(Pyrococcus furiosus)의 Pfu DNA 중합효소, 테르모코쿠스 종(Thermococcus sp.) 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스(Thermus aquaticus)의 Taq DNA 중합효소로부터 선택된 야생형 DNA 중합효소와 비교하여 적어도 하나의 개선된 특성을 갖는 조작된 DNA 중합효소.
  20. 제19항에 있어서, 야생형 DNA 중합효소와 비교하여 적어도 하나의 개선된 특성을 가지며, 상기 개선된 특성은 중합효소 연쇄 반응에서 증가된 생성물의 생산, 더 큰 충실도, 및 더 큰 열안정성으로부터 선택되는 것인 조작된 DNA 중합효소.
  21. 제1항 내지 제20항 중 어느 한 항에 있어서, 상기 조작된 DNA 중합효소는 중합효소 연쇄 반응에서 야생형 DNA 중합효소보다 큰 생산량을 생산하며, 상기 야생형 DNA 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택되는 것인 조작된 DNA 중합효소.
  22. 제1항 내지 제21항 중 어느 한 항에 있어서, 상기 조작된 DNA 중합효소는 야생형 DNA 중합효소보다 큰 충실도를 나타내며, 상기 야생형 DNA 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택되는 것인 조작된 DNA 중합효소.
  23. 제1항 내지 제22항 중 어느 한 항에 있어서, 상기 조작된 DNA 중합효소는 야생형 DNA 중합효소보다 큰 열안정성을 나타내며, 상기 야생형 DNA 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택되는 것인 조작된 DNA 중합효소.
  24. 제1항 내지 제23항 중 어느 한 항에 있어서, 상기 중합효소는 정제된 것인 조작된 DNA 중합효소.
  25. 제1항 내지 제24항 중 어느 한 항의 적어도 하나의 조작된 DNA 중합효소를 코딩하는 폴리뉴클레오티드 서열.
  26. 서열번호 1, 5, 21, 23, 25, 27 및/또는 823의 참조 서열 또는 이의 기능적 단편과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 서열 동일성을 포함하는 폴리뉴클레오티드 서열로서, 상기 조작된 폴리펩티드는 하나 이상의 아미노산 위치에서 적어도 하나의 치환을 포함하는 것인 폴리뉴클레오티드 서열.
  27. 제25항 또는 제26항에 있어서, 서열번호 2, 6, 22, 24, 26, 28 및/또는 824의 참조 서열과 적어도 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 서열 동일성을 갖는 서열을 포함하는 적어도 하나의 조작된 DNA 중합효소를 코딩하는 폴리뉴클레오티드 서열.
  28. 제27항에 있어서, 상기 서열은 서열번호 1, 5, 21, 23, 25, 27 및/또는 823을 포함하는 것인 폴리뉴클레오티드 서열.
  29. 제25항 내지 제28항 중 어느 한 항에 있어서, 제어 서열에 작동 가능하게 연결된 폴리뉴클레오티드 서열.
  30. 제25항 내지 제29항 중 어느 한 항에 있어서, 코돈-최적화된 폴리뉴클레오티드 서열.
  31. 제25항 내지 제30항 중 어느 한 항의 적어도 하나의 폴리뉴클레오티드 서열을 포함하는 발현 벡터.
  32. 제31항의 적어도 하나의 발현 벡터로 형질전환된 숙주 세포.
  33. 적어도 하나의 조작된 DNA 중합효소가 생산되도록 적절한 배양 조건하에서 제32항의 숙주 세포를 배양하는 단계를 포함하는, 숙주 세포에서 조작된 DNA 중합효소 폴리펩티드를 생산하는 방법.
  34. 제33항에 있어서, 배양물 및/또는 숙주 세포로부터 적어도 하나의 조작된 DNA 중합효소를 회수하는 단계를 추가로 포함하는 방법.
  35. 제34항에 있어서, 상기 적어도 하나의 조작된 DNA 중합효소를 정제하는 단계를 추가로 포함하는 방법.
  36. 제1항 내지 제24항 중 어느 한 항의 적어도 하나의 조작된 DNA 중합효소를 포함하는 조성물.
  37. DNA 중합효소 충실도를 결정하기 위한 고-처리량 분석 시스템.
  38. DNA 중합효소의 고-처리량 충실도 결정 방법으로서,
    i) 제1항 내지 제24항 중 어느 한 항에 제시된 적어도 하나의 DNA 중합효소; 제1 리포터 단백질 및 제2 리포터 단백질 및 선별 마커를 코딩하는 유전자를 포함하는 리포터 플라스미드; 중합효소 연쇄 반응을 수행하기 위한 열 순환기 및 시약을 포함하는 증폭 시스템; 및 정제 시스템; 적격 숙주 세포를 포함하는 형질전환 시스템; 및 유세포 분석기를 제공하는 단계; ii) 리포터 구축물이 상기 DNA 중합효소에 의해 증폭되어 PCR 생성물을 생산하도록 하는 조건하에서, 상기 DNA 중합효소 및 상기 리포터 플라스미드를 상기 증폭 시스템에 노출시키는 단계; iii) 상기 PCR 생성물을 원형화하여 원형화된 PCR 앰플리콘을 제공하는 단계; vi) 상기 형질전환 시스템을 이용하여 상기 PCR 앰플리콘을 형질전환시켜 형질전환된 세포를 생산하는 단계; 및 vii) 상기 유세포 분석기를 사용하여 상기 형질전환된 세포를 분석하는 단계; 및 viii) 상기 DNA 중합효소의 충실도를 결정하는 단계를 포함하는 방법.
  39. 제38항에 있어서, 상기 형질전환된 세포를 유도하는 단계를 추가로 포함하는 방법.
  40. 제38항 또는 제39항에 있어서, 상기 제1 리포터 단백질은 녹색 형광 단백질을 포함하는 것인 방법.
  41. 제38항 내지 제40항 중 어느 한 항에 있어서, 상기 제2 리포터 단백질은 dsRed를 포함하는 것인 방법.
  42. 제38항 내지 제41항 중 어느 한 항에 있어서, 상기 선별 마커는 클로람페니콜 아세틸트랜스퍼라아제를 포함하는 것인 방법.
  43. 제38항 내지 제42항 중 어느 한 항에 있어서, 상기 PCR 앰플리콘의 상기 원형화는 적어도 하나의 리가아제를 사용하여 수행되는 것인 방법.
  44. 제38항 내지 제43항 중 어느 한 항에 있어서, 상기 PCR 앰플리콘은 정제되는 것인 방법.
  45. 제38항 내지 제44항 중 어느 한 항에 있어서, 참조 DNA 중합효소와 비교하여 중합효소 충실도의 개선 배수를 결정하는 단계를 추가로 포함하는 방법.
  46. 제45항에 있어서, 참조 DNA 중합효소는 야생형 중합효소인 방법.
  47. 제46항에 있어서, 상기 야생형 중합효소는 피로코쿠스 퓨리오수스의 Pfu DNA 중합효소, 테르모코쿠스 종 균주 2319x1의 그룹 B DNA 중합효소, 및 테르무스 아쿠아티쿠스의 Taq DNA 중합효소로부터 선택되는 것인 방법.
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