KR101685209B1 - 유도된 다능성 줄기 세포의 효율적인 확립 방법 - Google Patents

유도된 다능성 줄기 세포의 효율적인 확립 방법 Download PDF

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KR101685209B1
KR101685209B1 KR1020107002641A KR20107002641A KR101685209B1 KR 101685209 B1 KR101685209 B1 KR 101685209B1 KR 1020107002641 A KR1020107002641 A KR 1020107002641A KR 20107002641 A KR20107002641 A KR 20107002641A KR 101685209 B1 KR101685209 B1 KR 101685209B1
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KR20110036523A (ko
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신야 야마나카
요시노리 요시다
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고쿠리츠 다이가쿠 호진 교토 다이가쿠
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

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KR1020107002641A 2008-07-30 2009-07-30 유도된 다능성 줄기 세포의 효율적인 확립 방법 Active KR101685209B1 (ko)

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Application Number Priority Date Filing Date Title
US8484208P 2008-07-30 2008-07-30
US61/084,842 2008-07-30
US14117708P 2008-12-29 2008-12-29
US61/141,177 2008-12-29
US20393108P 2008-12-30 2008-12-30
US61/203,931 2008-12-30
PCT/JP2009/063906 WO2010013845A1 (en) 2008-07-30 2009-07-30 Method of efficiently establishing induced pluripotent stem cells

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KR20110036523A KR20110036523A (ko) 2011-04-07
KR101685209B1 true KR101685209B1 (ko) 2016-12-09

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EP (1) EP2307539B1 (cg-RX-API-DMAC10.html)
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Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042490A1 (en) * 2008-10-06 2010-04-15 Boston Medical Center Corporation A single lentiviral vector system for induced pluripotent (ips) stem cells derivation
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
JP5637354B2 (ja) * 2009-03-30 2014-12-10 独立行政法人産業技術総合研究所 精製転写因子の調製法と細胞導入技術
US8900871B2 (en) 2009-08-07 2014-12-02 Kyoto University Method of producing induced pluripotent stem cells using inhibitors of P53
EP2470664A4 (en) 2009-08-27 2013-01-16 Synaptic Res Llc NEW PROTEIN RELEASE SYSTEM FOR GENERATING INDUCED PLURIPOTENTAL STEM CELLS OR TISSUE-SPECIFIC CELLS
WO2011032166A2 (en) * 2009-09-14 2011-03-17 The Johns Hopkins University Reprogramming blood cells to pluripotent and multipotent stem cells
WO2011062963A2 (en) * 2009-11-17 2011-05-26 Vitro Diagnositics, Inc. Induced puripotent stem cells and related methods
CA2802249A1 (en) 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
AU2011268056B2 (en) * 2010-06-18 2014-04-24 Cellular Dynamics International, Inc. Cardiomyocyte medium with dialyzed serum
JP6029137B2 (ja) 2010-12-03 2016-11-24 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
US9732319B2 (en) 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
JP6143265B2 (ja) 2011-07-25 2017-06-07 国立大学法人京都大学 人工多能性幹細胞の選別方法
RU2014117642A (ru) * 2011-10-03 2015-11-10 Ниссан Кемикал Индастриз, Лтд. Способ получения мегакариоцитов и/или тромбоцитов из плюрипотентных стволовых клеток
US20140248698A1 (en) 2011-10-21 2014-09-04 Arkray, Inc. Method for culturing pluripotency-maintained singly dispersed cells by means of laminar flow
WO2013077423A1 (ja) 2011-11-25 2013-05-30 国立大学法人京都大学 多能性幹細胞の培養方法
EP2832851B1 (en) 2012-03-28 2019-04-17 Quarrymen & Co. Inc. Immortalized stem cells and medicinal composition and medicinal preparation comprising product thereof as active ingredient
CA2874259C (en) 2012-05-23 2021-02-09 Kyoto University Highly efficient method for establishing induced pluripotent stem cell
US20150133467A1 (en) * 2012-06-06 2015-05-14 Kyoto University Screening method, protein instability and/or stability inducers, and protein activity assessment
CA3106271A1 (en) 2013-01-25 2014-07-31 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
EP2955223B1 (en) 2013-02-08 2019-12-18 Kyoto University Production methods for megakaryocytes and platelets
US9738861B2 (en) 2013-03-06 2017-08-22 Kyoto University Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells
US9790468B2 (en) 2013-03-15 2017-10-17 Avita Iinternational Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications
SG11201507829SA (en) 2013-03-21 2015-12-30 Univ Kyoto Pluripotent stem cell for neuronal differentiation induction
JP6473686B2 (ja) 2013-03-25 2019-02-20 公益財団法人神戸医療産業都市推進機構 細胞の選別方法
JP6461787B2 (ja) 2013-04-12 2019-01-30 国立大学法人京都大学 肺胞上皮前駆細胞の誘導方法
WO2014185358A1 (ja) 2013-05-14 2014-11-20 国立大学法人京都大学 効率的な心筋細胞の誘導方法
JP6378183B2 (ja) 2013-08-07 2018-08-22 国立大学法人京都大学 膵ホルモン産生細胞の製造法
CN121136933A (zh) 2013-09-05 2025-12-16 国立大学法人京都大学 由多能干细胞制造产多巴胺神经前体细胞的方法、产多巴胺神经前体细胞、帕金森病治疗剂和试剂盒
EP3064577B1 (en) 2013-11-01 2020-09-09 Kyoto University Novel chondrocyte induction method
FR3016372B1 (fr) * 2014-01-13 2018-01-19 Centre Leon Berard Procede de preparation de cellules pluripotentes induites
KR102297734B1 (ko) * 2014-01-24 2021-09-03 가부시키가이샤 쿠오리맨 앤 코. 암 치료용 의약 조성물 및 그 조성물을 유효 성분으로 하는 암 치료용 의약 제제
CN104894060B (zh) * 2014-03-03 2018-11-06 中国科学院上海生命科学研究院 诱导体细胞转分化为神经干细胞的方法及其应用
CN120536341A (zh) 2014-03-04 2025-08-26 菲特治疗公司 改良的重编程方法和细胞培养平台
AU2015290554A1 (en) 2014-07-18 2017-03-09 Kyoto University Method for inducing T cells for cell-based immunotherapy from pluripotent stem cells
US20180066223A1 (en) 2015-04-17 2018-03-08 Xcell Biosciences, Inc. Cancer cell enrichment system
EP3328995B1 (en) 2015-07-29 2021-03-31 Hadasit Medical Research Services And Development Large scale production of retinal pigment epithelial cells
CN117737124A (zh) 2015-10-16 2024-03-22 菲特治疗公司 用于诱导和维护基态多能性的平台
EP3447130A4 (en) 2016-04-22 2019-11-13 Kyoto University METHOD FOR PRODUCING DOPAMINE-PROPERING NEURAL PRESERVATOR CELLS
WO2017223199A1 (en) * 2016-06-22 2017-12-28 Xcell Biosciences, Inc. Methods for increasing cell culture transfection efficiency and cellular reprogramming
EP4595951A3 (en) 2016-11-10 2025-08-27 ViaCyte, Inc. Pdx1 pancreatic endoderm cells in cell delivery devices
US20210254013A1 (en) * 2018-06-14 2021-08-19 Figene, Llc Use of fibroblasts and/or modified fibroblasts for three dimensional tissue printing
US20210299331A1 (en) 2018-07-19 2021-09-30 Kyoto University Pluripotent stem cell-derived plate-shaped cartilage and method for producing the same
WO2020022261A1 (ja) 2018-07-23 2020-01-30 国立大学法人京都大学 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法
WO2020130147A1 (ja) 2018-12-21 2020-06-25 国立大学法人京都大学 ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物
US20220313734A1 (en) * 2019-05-09 2022-10-06 Figene, Llc Fibroblast generated patient-specific vaccines
EP3969571A4 (en) 2019-05-14 2023-05-24 Aleph Farms Ltd. PLURIPOTENTE CELL AGGREGATES AND THEIR USE
JP7058431B2 (ja) 2019-12-12 2022-04-22 国立大学法人千葉大学 巨核球および血小板を含む凍結乾燥製剤
US20230256024A1 (en) 2020-07-13 2023-08-17 Kyoto University Skeletal muscle precursor cells and method for purifying same, composition for treating myogenic diseases, and method for producing cell group containing skeletal muscle precursor cells
WO2022019152A1 (ja) 2020-07-20 2022-01-27 学校法人 愛知医科大学 多能性細胞の未分化維持培養用組成物、多能性細胞の未分化維持培養用培地、多能性細胞の未分化状態での維持培養方法、および多能性細胞の製造方法
JPWO2023153464A1 (cg-RX-API-DMAC10.html) 2022-02-09 2023-08-17
EP4306635A1 (en) * 2022-07-13 2024-01-17 La Fondation Cardiométabolisme et Nutrition Method for obtaining induced pluripotent stem cells (ipsc)
WO2024248017A1 (ja) 2023-05-29 2024-12-05 国立研究開発法人理化学研究所 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006073911A1 (en) * 2004-12-30 2006-07-13 Stemlifeline, Inc. Methods and compositions relating to embryonic stem cell lines

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020740A2 (en) 1997-10-23 1999-04-29 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
US20020090722A1 (en) * 2000-06-15 2002-07-11 Tanja Dominko Pluripotent mammalian cells
PT1572984E (pt) 2002-12-16 2016-06-03 Technion Res & Dev Foundation Sistema de cultura para células estaminais embrionárias humanas sem células alimentadoras e sem xeno
WO2006019366A1 (en) 2003-03-28 2006-02-23 Wisconsin Alumni Research Foundation Physiochemical culture conditions for embryonic stem cells
BRPI0514641A (pt) 2004-09-08 2008-06-17 Wisconsin Alumni Res Found cultivação das células tronco embriÈnica humana
EP2206724A1 (en) 2005-12-13 2010-07-14 Kyoto University Nuclear reprogramming factor
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
CN101605885B (zh) 2007-01-04 2013-03-27 卡尔·特吕格瓦松 能够使多能干细胞增殖的组合物及方法
DK3399025T3 (da) * 2007-03-23 2025-06-16 Wisconsin Alumni Res Found Omprogrammering af somatiske celler
US20120282229A1 (en) 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
EP2227540A4 (en) 2007-11-29 2011-11-02 Children S Hospital Of Orange County DIFFERENTIATION OF HUMAN CELLS
WO2009111087A1 (en) 2008-03-07 2009-09-11 Worcester Polytechnic Institute Novel use of basic fibroblast growth factor in the de-differentiation of animal connective tissue cells
JP5346925B2 (ja) * 2008-05-02 2013-11-20 国立大学法人京都大学 核初期化方法
WO2009142717A2 (en) * 2008-05-19 2009-11-26 President And Fellows Of Harvard College Methods and products for dedifferentiation of cells
CA2695590C (en) * 2008-06-27 2018-01-09 Kyoto University Method of efficiently establishing induced pluripotent stem cells
WO2010027062A1 (ja) 2008-09-04 2010-03-11 独立行政法人理化学研究所 B細胞由来iPS細胞およびその用途
JP5652783B2 (ja) * 2008-09-08 2015-01-14 独立行政法人理化学研究所 ＮＫＴ細胞由来ｉＰＳ細胞およびそれ由来のＮＫＴ細胞
CN101492676B (zh) * 2008-09-16 2011-02-16 中国科学院广州生物医药与健康研究院 用脑膜细胞生成诱导的多能性干细胞的方法及其用途
US8900871B2 (en) * 2009-08-07 2014-12-02 Kyoto University Method of producing induced pluripotent stem cells using inhibitors of P53

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006073911A1 (en) * 2004-12-30 2006-07-13 Stemlifeline, Inc. Methods and compositions relating to embryonic stem cell lines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cell. 131(5):861-872(2007.11.30.)*
Mol. Pharmacol. 69(4):1304-1310(2006.04.)*

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JP2011529329A (ja) 2011-12-08
KR20110036523A (ko) 2011-04-07
EP2307539A4 (en) 2012-10-24
US9528092B2 (en) 2016-12-27
CN101848994A (zh) 2010-09-29
JP5562231B2 (ja) 2014-07-30
WO2010013845A1 (en) 2010-02-04
CA2697621A1 (en) 2010-02-04
EP2307539A1 (en) 2011-04-13
CN107012123A (zh) 2017-08-04
US20110039338A1 (en) 2011-02-17
CA2697621C (en) 2017-01-17
EP2307539B1 (en) 2014-11-19

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