KR101677519B1 - 유기 화합물 - Google Patents
유기 화합물 Download PDFInfo
- Publication number
- KR101677519B1 KR101677519B1 KR1020117004733A KR20117004733A KR101677519B1 KR 101677519 B1 KR101677519 B1 KR 101677519B1 KR 1020117004733 A KR1020117004733 A KR 1020117004733A KR 20117004733 A KR20117004733 A KR 20117004733A KR 101677519 B1 KR101677519 B1 KR 101677519B1
- Authority
- KR
- South Korea
- Prior art keywords
- acetyl
- cyclohexylsulfanyl
- hydroxy
- mutilin
- amino
- Prior art date
Links
- FGICUYIIVQPFGM-UHFFFAOYSA-N CC(CCC1)CC1NC=O Chemical compound CC(CCC1)CC1NC=O FGICUYIIVQPFGM-UHFFFAOYSA-N 0.000 description 1
- QVJHLJGPSVCTGC-BYRXKDITSA-N CC(CC[C@@H](C1)N)[C@H]1O Chemical compound CC(CC[C@@H](C1)N)[C@H]1O QVJHLJGPSVCTGC-BYRXKDITSA-N 0.000 description 1
- FQRBUAGWWIZWRO-INPHLXTBSA-N CC(CC[C@@](CC1)([C@H]2C1=O)[C@@H](C)[C@@H]([C@@](C)(C1)C=C)O)[C@@]2(C)[C@@H]1OC(COS(c1ccc(C)cc1)(=O)=O)=O Chemical compound CC(CC[C@@](CC1)([C@H]2C1=O)[C@@H](C)[C@@H]([C@@](C)(C1)C=C)O)[C@@]2(C)[C@@H]1OC(COS(c1ccc(C)cc1)(=O)=O)=O FQRBUAGWWIZWRO-INPHLXTBSA-N 0.000 description 1
- 0 CC(CC[C@@](CC1)([C@]2C1=O)[C@](C)[C@@]([C@](C)(*)C1)O)[C@@]2(C)[C@@]1OC(CSC(CC1)C(*)CC1N*)=O Chemical compound CC(CC[C@@](CC1)([C@]2C1=O)[C@](C)[C@@]([C@](C)(*)C1)O)[C@@]2(C)[C@@]1OC(CSC(CC1)C(*)CC1N*)=O 0.000 description 1
- CHDRYUOQYFUCSQ-KZVJFYERSA-N C[C@H](C(N[C@@H](CC1)C[C@H](C)[C@H]1O)=O)N Chemical compound C[C@H](C(N[C@@H](CC1)C[C@H](C)[C@H]1O)=O)N CHDRYUOQYFUCSQ-KZVJFYERSA-N 0.000 description 1
- NOTBZDIDZXYYPU-FTLITQJKSA-N C[C@H](CC[C@H](C1)NC(C)=O)[C@@H]1O Chemical compound C[C@H](CC[C@H](C1)NC(C)=O)[C@@H]1O NOTBZDIDZXYYPU-FTLITQJKSA-N 0.000 description 1
- ZGRHSLPYQQCUGW-GHBZHPFISA-N C[C@H](C[C@@H](CC1)NC(C(C=[IH])C=[IH]=N)=O)[C@@H]1O Chemical compound C[C@H](C[C@@H](CC1)NC(C(C=[IH])C=[IH]=N)=O)[C@@H]1O ZGRHSLPYQQCUGW-GHBZHPFISA-N 0.000 description 1
- MGHXDNYCQMHROC-AYLPWXGPSA-N C[C@H](C[C@H](CC1)NC(C2NCCCC2)=O)[C@@H]1O Chemical compound C[C@H](C[C@H](CC1)NC(C2NCCCC2)=O)[C@@H]1O MGHXDNYCQMHROC-AYLPWXGPSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08450126A EP2159220A1 (de) | 2008-09-02 | 2008-09-02 | Organische Verbindungen |
| EP08450126.1 | 2008-09-02 | ||
| PCT/AT2009/000313 WO2010025482A1 (en) | 2008-09-02 | 2009-08-17 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110049837A KR20110049837A (ko) | 2011-05-12 |
| KR101677519B1 true KR101677519B1 (ko) | 2016-11-18 |
Family
ID=40377215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117004733A KR101677519B1 (ko) | 2008-09-02 | 2009-08-17 | 유기 화합물 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8222447B2 (de) |
| EP (2) | EP2159220A1 (de) |
| JP (1) | JP5628173B2 (de) |
| KR (1) | KR101677519B1 (de) |
| CN (2) | CN105503675A (de) |
| CA (1) | CA2734392C (de) |
| DK (1) | DK2321272T3 (de) |
| ES (1) | ES2582375T3 (de) |
| HK (1) | HK1153726A1 (de) |
| TW (1) | TWI473611B (de) |
| WO (1) | WO2010025482A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2399904A1 (de) * | 2010-05-26 | 2011-12-28 | Nabriva Therapeutics AG | Verfahren zur Herstellung von Pleuromutilinen |
| EP2433926A1 (de) | 2010-09-09 | 2012-03-28 | Nabriva Therapeutics AG | Pleuromutilin-Derivate zur Behandlung von Krankheiten vermittelt durch Mikroben |
| MX368101B (es) * | 2014-01-22 | 2019-09-19 | Nabriva Therapeutics Ag | 12-epi-pleuromutilinas. |
| EP3795553B1 (de) * | 2015-07-24 | 2024-05-15 | Celgene Corporation | Verfahren zur synthese von (1r,2r,5r)-5-amino-2-methylcyclohexanolhydrochlorid und nützliche zwischenprodukte darin |
| TWI762573B (zh) | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
| CN111170893B (zh) * | 2020-01-19 | 2022-04-26 | 郑州依米花手性药物研究有限公司 | Lefamulin的中间体化合物及其在Lefamulin制备中的应用 |
| CN111662220A (zh) * | 2020-04-20 | 2020-09-15 | 常州安蒂卫生物科技有限公司 | 用于治疗新型冠状病毒肺炎继发细菌感染性疾病的截短侧耳素类化合物 |
| CN115850137B (zh) * | 2022-11-12 | 2024-04-12 | 中国农业科学院兰州畜牧与兽药研究所 | 一种截短侧耳素衍生化合物及其制备方法与应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004502755A (ja) * | 2000-07-11 | 2004-01-29 | バイオケミ・ゲゼルシヤフト・エム・ベー・ハー | 抗細菌活性を有するプレウロムチリン誘導体 |
| JP2005529088A (ja) | 2002-03-28 | 2005-09-29 | サンド・アクチエンゲゼルシヤフト | プルロムチリン誘導体を使用する結核症治療 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT400674B (de) * | 1991-07-24 | 1996-02-26 | Biochemie Gmbh | Pharmazeutische pleuromutilin-zubereitung |
| GB0209262D0 (en) | 2002-04-23 | 2002-06-05 | Biochemie Gmbh | Organic compounds |
| PL373460A1 (en) * | 2002-07-24 | 2005-08-22 | Sandoz Ag | Pleuromutilin derivatives as antimicrobbials |
| DE602006021174D1 (de) * | 2005-06-13 | 2011-05-19 | Intier Automotive Inc | Plattenneigungsvorrichtung mit speicher |
| EP2298733B1 (de) | 2005-06-27 | 2016-05-25 | Nabriva Therapeutics AG | Pleuromutilinderivate mit einer Hydroxyamino- oder Acyloxyaminocycloalkylgruppe |
| GB0515995D0 (en) | 2005-08-03 | 2005-09-07 | Sandoz Ag | Organic compounds |
| EP1972618A1 (de) | 2007-03-20 | 2008-09-24 | Nabriva Therapeutics AG | Pleuromutilin-Derivate zur Behandlung von Krankheiten vermittelt durch Mikroben |
-
2008
- 2008-09-02 EP EP08450126A patent/EP2159220A1/de not_active Withdrawn
-
2009
- 2009-08-17 EP EP09810900.2A patent/EP2321272B1/de active Active
- 2009-08-17 KR KR1020117004733A patent/KR101677519B1/ko active IP Right Grant
- 2009-08-17 WO PCT/AT2009/000313 patent/WO2010025482A1/en active Application Filing
- 2009-08-17 CA CA2734392A patent/CA2734392C/en active Active
- 2009-08-17 DK DK09810900.2T patent/DK2321272T3/en active
- 2009-08-17 JP JP2011524129A patent/JP5628173B2/ja active Active
- 2009-08-17 ES ES09810900.2T patent/ES2582375T3/es active Active
- 2009-08-17 CN CN201510920380.5A patent/CN105503675A/zh active Pending
- 2009-08-17 US US13/061,692 patent/US8222447B2/en active Active
- 2009-08-17 CN CN2009801349869A patent/CN102143944A/zh active Pending
- 2009-08-24 TW TW98128395A patent/TWI473611B/zh active
-
2011
- 2011-07-27 HK HK11107820.8A patent/HK1153726A1/zh not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004502755A (ja) * | 2000-07-11 | 2004-01-29 | バイオケミ・ゲゼルシヤフト・エム・ベー・ハー | 抗細菌活性を有するプレウロムチリン誘導体 |
| JP2005529088A (ja) | 2002-03-28 | 2005-09-29 | サンド・アクチエンゲゼルシヤフト | プルロムチリン誘導体を使用する結核症治療 |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1153726A1 (zh) | 2012-04-05 |
| ES2582375T3 (es) | 2016-09-12 |
| US8222447B2 (en) | 2012-07-17 |
| EP2321272B1 (de) | 2016-04-20 |
| EP2321272A1 (de) | 2011-05-18 |
| CA2734392A1 (en) | 2010-03-11 |
| JP2012501300A (ja) | 2012-01-19 |
| CN105503675A (zh) | 2016-04-20 |
| CA2734392C (en) | 2017-08-29 |
| EP2159220A1 (de) | 2010-03-03 |
| KR20110049837A (ko) | 2011-05-12 |
| TW201019933A (en) | 2010-06-01 |
| TWI473611B (zh) | 2015-02-21 |
| DK2321272T3 (en) | 2016-08-01 |
| CN102143944A (zh) | 2011-08-03 |
| US20110184022A1 (en) | 2011-07-28 |
| JP5628173B2 (ja) | 2014-11-19 |
| WO2010025482A1 (en) | 2010-03-11 |
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|---|---|---|
| KR101677519B1 (ko) | 유기 화합물 | |
| KR101478593B1 (ko) | 미생물에 의해 매개되는 질병 치료용 플루로뮤틸린 유도체 | |
| US9278920B2 (en) | Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| AMND | Amendment | ||
| X701 | Decision to grant (after re-examination) | ||
| GRNT | Written decision to grant |