KR101591614B1 - Protectant against urinary calculi - Google Patents

Abstract

The present invention relates to a solid acid as a main component; Porous adsorbent; An oil phase volatile material adsorbed on the porous adsorbent; And a powdering agent, and an anticorrosion preventing agent for a toilet drain pipe comprising the pressed molded article.

Description

{PROTECTANT AGAINST URINARY CALCULI}

The present invention relates to a pressed molded article containing an oil-based volatile substance as a main component by means of tableting and an anti-stone agent comprising the tablet-shaped molded article. The antidrombustion agent of the present invention can be applied to various kinds of flush toilet or toilet for men who do not have washing facilities.

A scale called urine stone adhered to a mixture of a calcium compound or an organic substance produced by the decomposition of urine is generated in the drain pipe of a toilet drain pipe, particularly a toilet for men, and the flow of urine and washing water is deteriorated, In severe cases, the drain canal is closed and the toilet becomes unusable. In addition, the organic matter in the urine is decayed by the bacteria, and the odor is generated. The odor of a toilet for men is a mixture of odor caused by decay of organic matter and ammonia generated by decomposition of urine.

Conventionally, as a method for preventing the scale of a toilet drain pipe, a method of injecting a medicine in the middle of a washing water pipe and a method of injecting a spherical shaped medicine into a toilet of a man's toilet have been put to practical use. As the medicines to be used in these methods, various ones containing a surfactant, a bactericide and a flavor have been proposed.

For example, Patent Document 1 discloses a deodorant detergent for a flush toilet in which a surfactant, an ion blocker, a perfume or the like is melt-mixed together with polyethylene glycol or polypropylene glycol and an aromatic material, Document 2 discloses a cleaning and stainproofing fragrance which is formed by cooling and solidifying a mixed melt composed of solid polyethylene glycol, a poorly water-soluble aromatic material, a nonionic surfactant, and a flavor and the like at room temperature. Further, as a method of controlling the scale once adhered to the toilet drain pipe, a method of dissolving the scale by using an inorganic strong acid such as hydrochloric acid, and a method of mechanically removing the scale by disassembling the toilet are adopted.

However, all of the above methods have problems such that the effect of preventing the scale from sticking to the toilet drain pipe is not sufficient, or that even if the sticking prevention effect is obtained, it is expensive, the operation is large, or the purification tank is adversely affected.

Thus, the present applicant has developed an anti-stones agent comprising a molded article comprising a solid acid as an effective ingredient (Patent Document 3).

After that, the present applicant proposes an antiseptic agent containing a solid acid as a main component and containing a flavor and the like (Patent Document 4). However, when a volatile substance such as a fragrance or an insecticide is contained, It has been difficult to produce a molded article of an antimony-repellent agent.

Patent Document 1: JP-A-45-30706 Patent Document 2: JP-A-57-168668 Patent Document 3: JP-A-62-38299 Patent Document 4: JP-A-2-147699

Summary of the Invention

Challenges to be solved by the invention

The present invention has been made in view of such circumstances, and an object of the present invention is to provide an antidandruff agent which has a sustained release of a volatile substance such as a fragrance for a long period of time and is hardly collapsed.

Means for solving the problem

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that, by kneading an oil phase volatile flavor together with a porous adsorbent, and kneading the kneaded raw material with a powder base, The present inventors have found that a long-term sustained release of fragrance and a stable directional antiseptic agent can be formed. In addition, it has been found that insecticides and the like have the same effect on oil-phase volatility, It came.

That is, the present invention relates to the following (1) to (6).

(1) a solid acid as a main component;

Porous adsorbent;

An oil phase volatile material adsorbed on the porous adsorbent; And

Powdering agent

.

(2) The pressed molded article according to (1), wherein the oil-based volatile substance is a perfume, a repellent, an insect repellent, a deodorant or a deodorant.

(3) The shaped molded article according to (1) or (2), wherein the pulverizing agent is a polysaccharide.

(4) The pressed molded article according to any one of (1) to (3), wherein the pulverizing agent is gum.

(5) The formed shaped article according to any one of (1) to (4), wherein the porous adsorbent on which the oil phase volatile substance is adsorbed is dispersed in the powdery base.

(6) An antidandruff agent for a toilet drain pipe comprising the molded article according to any one of (1) to (5).

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to obtain a tablet having stability that can be contained without volatile perfume of oil-like origin exuding on the surface of the tablets and without being disintegrated for a long period of time. Further, the present invention can be applied to a fungicide or a pest repellent other than a perfume as long as it is an oil-phase volatile substance.

Carrying out the invention  Form for

(Antiseptics)

The antidrombustion agent of the present invention comprises a pressed body containing a solid acid as an effective component and containing a porous adsorbent, a powdering base agent and an oil phase volatile substance.

Hereinafter, each component will be described.

(Solid acid)

In the present invention, a solid acid is an acidic substance which is solid at room temperature and does not generate a salt having a solubility of 0.001 g / 100 g (water) or less in water having a pH in the range of 5 to 8.5 by reacting with calcium ions. , There is no limitation. For example, water-soluble acid salts such as sodium hydrogen sulfate, potassium hydrogen sulfate and ammonium hydrogen sulfate, water-soluble salts with strong acids and weak bases such as ammonium chloride and ammonium sulfate, and boric acid and sulfamic acid. In addition, organic acids such as succinic acid, citric acid, maleic acid, isophthalic acid, tartaric acid, hydroxyacetic acid, p-toluenesulfonic acid, fumaric acid, adipic acid, salicylic acid, pseudocylic acid, hydroxycarboxylic acid, maleic anhydride and benzoic acid These acidic substances can be used singly or as a mixture of two or more kinds.

The content of the solid acid in the pressed compact is generally 50 to 95% by mass, preferably 75 to 95% by mass.

(Oil-based volatile substances)

In the present invention, the oil-phase volatile substance means a substance containing a volatile component that is not water-soluble. In addition to the fragrance, a repellent or an insect repellent, a deodorant or a deodorant, a pesticide, or an agricultural chemical may be used.

As the fragrance, natural fragrance, synthetic fragrance, combination fragrance and the like can be used without particular limitation as long as it masks the odor of the toilet and the smell of the antiseptic agent and gives a favorable feeling to the user. Examples of the natural flavor include natural flavorings such as mastic oil, parsley oil, anise oil, eucalyptus oil, wintergreen oil, cacao oil, menthol oil, spearmint oil, peppermint oil, lemon oil, , Lime oil, lavender oil, laurel oil, camomile oil, cardamom oil, caraway oil, beei, lemongrass oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, Absolute peppermint, Rose, orange flower, citrus oil, mix fruit oil, strawberry oil, cinnamon oil, clove oil, grape oil and the like.

Examples of the synthetic fragrance include carborane, anethole, methyl salicylate, cinnamic aldehyde, linaroyl, linaryl acetate, limonene, menton, menthyl acetate, pinene, octylaldehyde, citral, figon, carvir acetate, anisaldehyde, Butanol, isoamyl alcohol, hexanol, isoamyl alcohol, butanol, isopropyl alcohol, propyl alcohol, isopropyl alcohol, butyl alcohol, Dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate and the like.

Combination flavors, including synthetic flavors and / or natural flavors, include strawberry flour, apple flour, banana flour, pineapple flour, grape flour, mango flour, tropical fruit flour, butter flour, Burberry, yogurt fl avor, fruit mix flavor, and herb mint flavor.

Examples of the repellent or insect repellent, deodorant or deodorant, pesticide, pesticide and the like include the following.

Examples of repellents or insect repellants include capsaicin, peppermint oil, eucalyptus, cypress, Numminoki, menthol oil, allyl isothiocyanate, methyl salicylate, ethyl salicylate, nonylsubanilylamide and the like.

Examples of the deodorant or deodorant include phthalic acid ester, phosphoric acid ester, vegetable milk extract, terpene deodorant and the like.

Examples of the pesticide include phenitrothion, methyl parathion, parathion, diadinone, warfarin, alachlor, pyretrin, cycloheximide, cetoxydim, trifumisole and the like.

Examples of insecticides include permethrin, pyrethroid compounds, fipronil and the like.

The content of the volatile substance in the pressed compact is usually from 0.1 to 5.0% by mass, and preferably from 1.0 to 2.0% by mass.

(Porous adsorbent)

In the present invention, the porous adsorbent is used for the purpose of adsorbing and retaining the above-mentioned oil phase volatile substances and further having sustained release properties. The porous adsorbent is not particularly limited as long as fine pores or fine pores having minute pores are present, but it is preferable that the average primary particle diameter is 1.0 to 120 탆 and the porosity is 1.0 to 2.0 mL / g.

Examples of the fine particles include organic and inorganic fine particles, and examples of the organic fine particles include porous cellulose and porous cellulose derivatives.

As the inorganic fine particles, for example, calcium silicate, silicon dioxide, hydrated silicon dioxide; Silicic anhydride such as light anhydrous silicic acid, magnesium silicate, and magnesium metasilicate aluminate; Zeolite and the like. Examples of the calcium silicate include Fluorite R (Tokuyama), Silica (Fuji Silica), Caprex (Shionogi Seiyaku) as the hydrated silicon dioxide, AEROSIL (Japanese Aerosil) as the hard anhydrous silicic acid, As magnesium hydroxide, neichirin (Fujikagakuko Bridge) and the like are commercially available and can be easily obtained.

The content of the porous adsorbent in the pressed compact is usually 0.1 to 5% by mass, preferably 0.1 to 1% by mass, more preferably 0.2 to 0.7% by mass.

(Powdered base)

In the present invention, the pulverizing base usually used as an excipient for an oily substance can be used, and is used as an adsorbing aid for the porous adsorbent. As the powdering agent, polysaccharides are preferable, and examples thereof include gums such as gum arabic, xanthan gum, tragacanth gum, gellan gum, locust gum gum and tamarind seed gum, carrageenan, agar, LM pectin and HM pectin.

The polysaccharide to be used in the pulverizing agent is preferably a polysaccharide mainly containing a polysaccharide having a molecular weight of 1000 or more, more preferably 30,000 to 300,000.

The content of the pulverizing agent in the pressed molded article is usually 0.1 to 45% by mass, preferably 1 to 15% by mass.

The ratio of the porous adsorbent to the powdery base is 1 to 450 parts by mass, preferably 5 to 450 parts by mass, more preferably 10 to 100 parts by mass, relative to 1 part by mass of the porous adsorbent.

(Other additives)

In addition to the above additives, a coloring agent such as a dissolution rate adjusting agent, a surfactant, and a pigment, a corrosion inhibitor, a bactericide, an ion blocker, a binder, a lubricant and the like may be added to the antirheum agent of the toilet drain pipe of the present invention.

(quite)

The process for the preparation of the antidepressant of the present invention is not particularly limited as long as it can contain the oil-phase volatile substances without oozing out and can have stability that can withstand use for a long period of time without collapsing. A step of kneading the oil phase volatile material together with the porous adsorbent to prepare a kneaded raw material, (B) a step of kneading the kneaded raw material together with the powdered base, (C) other components such as a solid acid, , It is preferable to perform tablet molding.

The step (A) is a step of adsorbing an oil phase volatile substance to a porous adsorbent, and can be kneaded by a known method. The kneading time is not particularly limited, but is usually from 1 minute to 20 minutes. The kneading temperature is not particularly limited, but is usually 10 to 30 占 폚.

The step (B) is a step of kneading the kneaded product obtained in the step (A) with a powdering base agent, and kneading can be carried out by a known method. The kneading time is not particularly limited, but is usually from 1 minute to 20 minutes. The kneading temperature is not particularly limited, but is usually 10 to 30 占 폚.

The step (C) is a step of mixing the kneaded product obtained in the step (B) with the other components and then finishing the mixture by a known method.

The antidrombustion agent of the present invention can be compressed into any shape, for example, a spherical shape, a columnar shape, a hollow cylindrical shape, a disc shape, a cube shape, a circular shape, a prism shape, an animal or animal shape, and the like.

In the above process of the present invention, when the powdery base material is used in place of the porous material in the step (A), or when the step (A) and the step (B) are carried out simultaneously, the molded article exhibiting the effect of the present invention It is difficult to obtain.

Example

Hereinafter, the present invention will be described in more detail with reference to Examples. However, the scope of the present invention is not limited by the following examples.

The meaning of the abbreviation is as follows.

HPC: hydroxypropylcellulose

St-Ca: calcium stearate

In the examples, the makers of raw materials used are as follows.

HPC-SL: manufactured by Nippon Soda K.K.

DK ester F20W: made by Daiichi Kyoei Co., Ltd.

Chromophthal blue: manufactured by Chiba Specialty Chemicals Co., Ltd.

Gum arabic: manufactured by Wako Junyaku Kogyo Co., Ltd. (reagent)

Syriac (registered trademark): manufactured by Fuji Silysia Chemical Industries, Ltd.

NOISILIN (registered trademark): manufactured by Fujikawa Kakuko Kogyo Co., Ltd.

Zeolite: manufactured by Nittohon Kako Corporation

alpha gel (registered trademark): manufactured by Alpha Japan Co., Ltd.

GREEN APPLE AF-17735, -18046: manufactured by Soda Kogyo Co., Ltd.

ORANGE AF-18047: manufactured by Soda Kogyo Co., Ltd.

CLEAN DEW AF-18048: manufactured by Soda Kogyo Co., Ltd.

PERFUME 17823: manufactured by Soda Kogyo Co., Ltd.

PERFUME 17824: manufactured by Soda Kogyo Co., Ltd.

FRUITY FLORA AF-17737: manufactured by Soda Kogyo Co., Ltd.

[Example]

(Preparation of antiseptics)

In a ratio shown in Table 1, a liquid flavoring agent and Sialia (registered trademark) (amorphous silicon dioxide manufactured by Fuji Silysia) were mixed and kneaded for 5 minutes in a mortar. In addition, a predetermined amount of gum arabic was added and kneaded for 10 minutes in a mortar. The other additives were added to this kneaded product to prepare a uniform mixture, and the cylindrical anti-statging agents 1 to 12 of the present invention having a diameter of 40 mm and a thickness of 25 mm were produced by a tableting machine (UD100 · 90, manufactured by MASHINA KABUSHIKI KAISHA) Respectively.

(Evaluation test)

The anti-stone agents 1 to 12 in the present invention were each subjected to an evaluation test on the following items. The results are shown in Table 2.

(Ⅰ) Mixing test of raw powder

After the blending of the raw materials, the presence or absence of sticking of moisture and stickiness was confirmed. &Quot;, " & cir & ", and " x "

(Ⅱ) Tabletting test

(II-1) Satisfactory

The presence or absence of capsular damage such as capping and trunk fracture when the tablet was tableted was confirmed. The samples excellent in stability were evaluated as & cir &

(II-2) Flowability of the raw material

The state of the drop of the raw material from the raw hopper to the mortar was confirmed. The samples with excellent fluidity were evaluated as & cir &

(Ⅱ-3) Attaching the mold of the raw material

The presence or absence of metal mold adhesion was confirmed. &Quot; & cir & ≤, "

(Ⅲ) Abuse test

The medicines were placed in an aluminum lamina dip and stored in a thermostatic chamber at 60 DEG C for 7 days to confirm alteration and discoloration. No change, and the like were evaluated as & cir &

(IV) Collapse test

One liter of tap water was added to a 1 L poly cup, and one tablet of anti-stone inhibitor was submerged therein, and the mixture was allowed to stand for three days to confirm cracking and collapse of the drug. And those with no cracks were rated " ", and those with " cracks "

(V) direction effect

The anti-inflammatory agent of the present invention was placed in a cassette (plastic container) in a drain pipe of a male urinal for one month, and the presence or absence of the direction was confirmed by sensory evaluation. A feeling that a strong direction (fragrance) was felt was rated as?, A feeling that a direction was felt was rated as?, And a feeling that a direction was not felt was rated as?.

[Comparative Example]

[Comparative Example 1] In the case where the adsorbent (porous adsorbent and powdered base) was not included

(Preparation of antiseptics)

In the proportions shown in Table 3, powdery flavor or liquid flavor and other additives were put into a poly bag and mixed for 1 minute. From the uniform mixture, spherical anti-statging agents 13 to 28 having a diameter of 40 mm and a thickness of 25 mm were produced by a tableting machine. Further, an anti-stone agent containing no fragrance was prepared in the same manner to give a composition 29.

(Evaluation test)

Evaluation tests were carried out in the same manner as in the Examples. The results are shown in Table 4.

As is apparent from Table 4, although the fragrance of the powder was easy to grind, the fragrance did not obtain the directionality, and the liquid fragrance obtained the directionality, but it was difficult to make the tablet.

[Comparative Example 2] In the case where either the porous adsorbent as the adsorbent or the powdery base was not used

(Preparation of antiseptics)

In the proportions shown in Table 5, the liquid flavor and other additives were put in a poly bag and mixed for 1 minute. From the uniform mixture, cylindrical antireflective agents 30 to 41 having a diameter of 40 mm and a thickness of 25 mm were prepared by a tableting machine.

(Evaluation test)

Evaluation tests were carried out in the same manner as in the Examples. The results are shown in Table 6.

As is clear from Table 6, when either of the porous adsorbent as the adsorbent and the pulverizing agent was not used, the tablets having both directionality and stability were not obtained.

[Comparative Example 3] When the order of addition of the porous adsorbent and the pulverizing agent as the adsorbent was reversed to that of the examples

(Preparation of antiseptics)

In a ratio shown in Table 7, liquid fragrance and gum arabic were placed in a poly bag and mixed for 1 minute. Further, other additives were added to prepare a homogeneous mixture, and cylindrical antirust preventing agents 42 to 50 having a diameter of 40 mm and a thickness of 25 mm were prepared by a tableting machine.

(Evaluation test)

Evaluation tests were carried out in the same manner as in the Examples. The results are shown in Table 8.

As is clear from Table 8, only the order of addition of the porous adsorbent and the pulverizing agent were different, and the deterioration in the qualitative test was observed, and the direction was lower than in the Examples.

Industrial availability

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to obtain a tablet having stability that can be contained without volatile perfume of oil-like origin exuding on the surface of the tablets and without being disintegrated for a long period of time. Further, the present invention can be applied to a fungicide or a pest repellent other than a perfume as long as it is an oil-phase volatile substance.

Claims (6)

Solid acids;
Porous adsorbent;
An oil phase volatile material adsorbed on the porous adsorbent; And
Powdering agent
A shaped press molding comprising:
The content of the solid acid in the pressed compact is 50 to 95% by mass,
Wherein the content of the oil phase volatile substance in the pressed compact is 0.1 to 5.0 mass%
The content of the porous adsorbent in the pressed compact is 0.1 to 5% by mass,
Wherein the ratio of the porous adsorbent to the powdered base agent is 5 to 100 parts by mass based on 1 part by mass of the porous adsorbent and the oil phase volatile substance is kneaded together with the porous adsorbent to produce a kneaded raw material, Subsequently kneading the kneaded raw material with a powdered base material to prepare a kneaded product, mixing the kneaded product with other components, and subjecting the kneaded product to compression molding. The method according to claim 1,
Characterized in that the oil phase volatile substance is a perfume, a repellent, an insect repellent, a deodorant or a deodorant. 3. The method according to claim 1 or 2,
Wherein the pulverizing agent is a polysaccharide. The method of claim 3,
Wherein the pulverizing agent is gum. The method according to claim 1,
Wherein the porous adsorbent on which the oil phase volatile substance is adsorbed is dispersed in the powder base. An antidandruff agent for a toilet drain pipe comprising the pressed molded article according to claim 1.