JP4541076B2 - Urine stone adhesion inhibitor - Google Patents

Description

The present invention relates to a urinary adhesion inhibitor to prevent the urine stone from adhering to the drainage portion of the urinal for man child.

  In general, a device called a “eye plate” is installed in the lower drainage portion of the men's urinal, and urine is discharged from the drainage portion where the eye plate is installed. In such a urinal, salts such as calcium and phosphorus, which are components in the urine, are deposited and solidified from the attached urine to adhere and solidify as urine stones. It is not easy to remove the collected urine stone by cleaning or the like. If the urine stone adhering to the drainage part of the urinal which is difficult to remove by such cleaning or the like is left as it is, there is a possibility that the toilet bowl may be damaged by a crack, and therefore it is necessary to remove it quickly.

  In general, acids such as hydrochloric acid and sulfamic acid are used as such urine stone removal means because they cannot be easily removed by a detergent or the like used for cleaning. Although these acids have a certain removal effect, these hydrochloric acids, sulfamic acids, and the like are strong acids, and thus there are problems in terms of handling during use and safety of the working environment as well as their production.

  Moreover, these acids will corrode the piping, when metal piping exists in the lower part of the toilet drainage part. Furthermore, it not only has the possibility of adversely affecting the human body, such as generation of toxic gases, but is also not preferable from the viewpoint of destroying the global environment.

  In view of these problems, patent applications such as the following Patent Document 1 have also been filed. The invention according to Patent Document 1 consists of a neutral aqueous solution containing some selected from potassium hydroxide, phosphoric acid, sodium carbonate, hydrogen peroxide, and the like as a main component.

JP 2000-296171 A

  However, although the invention according to Patent Document 1 does not use generally used hydrochloric acid or sulfamic acid, it uses acid or alkali selectively, so that it is safe to handle and work environment. This problem cannot be fundamentally solved, and at least it is not easy for general workers to handle. Moreover, since acids and alkalis are selectively used, the possibility of corroding the piping is not eliminated. Moreover, safety is not guaranteed. In addition, since there are useful microorganisms that decompose organic waste in the flow path to the lower part of the toilet drainage part and the piping part, the above-mentioned acids and alkalis are It is not originally preferable for these useful microorganisms to flow into the plant.

  Such men's urinals are almost never installed in ordinary households in recent years, but in public places such as parks, railway stations and interiors of vehicles, movie theaters, highway rest areas, etc. Since it is still installed and it has become difficult to secure cleaning workers year by year, it is a drug that can prevent urinary stones from adhering to men's urinals in such public toilets, It is required to use an alternative to such acids.

  The present invention has been made to solve such problems, and can prevent urinary stones from adhering to the urine, and it is easy to handle even a general user and has extremely high safety. It is an object of the present invention to provide a slowly soluble drug such as a stone adhesion preventive agent.

The present invention has been made in order to solve such problems. In the present invention , a urinary stone adhesion inhibitor, a culture of Bacillus Natto or Bacillus natto , and 50% by weight or more of iota-type carrageenan in the mixture. It contains a gelling agent comprising a carrageenan mixture containing, a dissolution retarder comprising furceleran that delays dissolution of the gelling agent, and a deodorant comprising a plant extract.

  Since the slow-dissolving agent such as the urinary stone adhesion inhibitor of the present invention contains a culture of Bacillus Natto or Bacillus natto, a slow-dissolving agent such as such a urinary stone anti-adhesive agent is used. By preliminarily installing it on a part of the urinal of a boy's urinal, adhesion of urinary stones is prevented by the action of Bacillus Natto. Moreover, natto (Bacillus Natto) has a deodorizing action, and the bad odor due to long-term use of the urinal is also alleviated. Moreover, since Bacillus Natto itself is used for food, it is highly safe for the human body.

  In addition, since the slow-dissolving drug such as the urinary stone adhesion preventive agent of the present invention contains a gelling agent composed of a natural polymer, the drug itself has excellent shape retention, and is a urinal dish. It can be easily installed on the parts. Further, since the gelling agent is made of a natural polymer, the safety is high.

  Furthermore, since the slow-dissolving agent such as the urinary stone adhesion preventive agent of the present invention contains a dissolution retardant composed of a natural polymer, it is preferable that the gelling agent dissolves quickly due to urine liquid or the like. Will be prevented. Moreover, since the dissolution retardant is made of a natural polymer, safety is high.

  Furthermore, since the slow-dissolving agent such as the urine stone adhesion preventing agent of the present invention contains a deodorant comprising a plant extract, the deodorizing effect is extremely excellent due to the synergistic action with the natto bacteria. It will be. In addition, since the deodorant is made of a plant extract, safety is high.

Furthermore, since the thing which consists of a carrageenan mixture is used as a gelatinizer which consists of natural polymers , and carrageenan itself is a sticky substance extracted from a seaweed, it becomes a safer thing. In particular, iota-type carrageenan is most suitable as a gelling agent for urine stone anti-adhesive agent placed in the urinal eyeplate, such as hardness and solubility, and such iota-type carrageenan is contained in the carrageenan mixture. By containing 50% by weight or more in the composition, it can be used more suitably as a urolith adhesion inhibitor.

In addition, since ferceleran is used as a dissolution retarder composed of a natural polymer, the effect of delaying the dissolution of a gelling agent composed of a carrageenan mixture in water is extremely excellent. Since furcellaran itself is used for an edible, Ru der those also highly safe to the human body.

  In the urine stone adhesion preventing agent of this embodiment, an adhesion preventing agent stock solution, an antioxidant, a gelling agent, a dissolution retardant, and the like are blended. The stock solution for anti-adhesion contains a natto bacteria culture, a chelating agent, a surfactant, a deodorant comprising a plant extract, alcohol, opacifier, and pigment.

  The blending amount of each component of the anti-adhesion agent stock solution is not particularly limited, but the deodorant comprising a plant extract is 1.0 to 2.5% by weight, the chelating agent is 0.3 to 0.5% by weight, and the interface It is preferred that the activator is 1.2 to 1.5% by weight and the alcohol is 1.2 to 1.5% by weight. The Bacillus natto culture is the remaining amount except for this, but most of it is water except for the medium components for culturing Bacillus natto. The pH is adjusted to about 7.0 to 9.0.

  As the chelating agent, for example, ethylenediaminetetraacetic acid soda, hydroxyethylethylenediaminetriacetic acid, nitrilotriacetic acid, diethylenetriaminepentaacetic acid and the like are used. As the surfactant, for example, a natural alcohol surfactant such as alkoxylate linear alcohol, lauryl alcohol or oleyl alcohol, an alkylphenol surfactant such as nonylphenol ethoxylate, or the like is used. Further, as the Bacillus natto culture, a culture such as a culture obtained by culturing commercially available Bacillus natto in a medium containing saccharides such as sucrose and glucose, soybean protein and the like is used. As the pigment, for example, a natural pigment such as edible blue No. 1 (manufactured by Sakai Kasei Corporation) is used. Furthermore, as a deodorant comprising a vegetable extract, for example, an extract of pine, cypress, hiba, bamboo, tea leaves, or lemon oil, orange oil, lime oil, bergamot oil, cedar oil, cinnamon oil, camphor oil, Ginger oil, lavender oil, rosemary oil, thyme oil, sage oil, copaiba oil and the like can be used, and two or more of these can be used in combination. It is also possible to use other plant extracts.

  Further, as the gelling agent, a carrageenan mixture is mainly used in the present invention. This carrageenan mixture is a mixture of isomers having different molecular structures, and in the present invention, among the kappa-type carrageenan, iota-type carrageenan, and lambda-type carrageenan, which are generally known as three isomers, mainly iota A type carrageenan containing 60 to 90% by weight and a copper type carrageenan containing 10 to 30% by weight is used.

As the solution retarders, off Aserera down the Ru used. Et al is, as the antioxidant, for example, dibutylhydroxytoluene, erythorbic acid, sodium erythorbic acid, isopropyl citrate, dl-alpha-tocopherol, nordihydrocapsaicin grayed Aya REC acids, like gallic acid.

  Examples of the present invention will be described below.

Example 1
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 1.0%
Far Celeran 1.8%
Locust bean gum 0.2%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

  As the carrageenan mixture, a mixture containing 80% by weight of iota-type carrageenan and 20% by weight of copper-type carrageenan (trade name NEWGELIN X-04122S: Chuo Foods Corporation) was used.

The composition of the anti-adhesion agent stock solution is as follows.
Ingredient Amount (wt%)
Bacillus natto culture 94.2%
Plant extract deodorant 1.5%
Ethylenediaminetetraacetate 0.4%
Alkoxylate linear alcohol 1.3%
Ethoxylate alcohol 1.3%
Opacifier 0.3%
Natural pigment 1.0%
In addition, the Bacillus natto culture was prepared as follows. That is, a liquid medium composed of 30.0 g of sucrose, 40.0 g of soybean peptone, 2.5 g of potassium phosphate, 5.0 g of sodium chloride and 900 mL of water was prepared, and this liquid medium was put into a 2000 mL flask. After sterilization, commercially available natto bacteria were inoculated, and static culture was performed for 20 days in a 35 ° C. incubator, and this was used as the natto bacteria culture.

  The gel point of the urine stone adhesion inhibitor of this example was 44 ° C.

(Example 2)
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 1.5%
Far Celeran 1.4%
Locust bean gum 0.1%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

  The same carrageenan mixture as in Example 1 was used. The composition of the anti-adhesion agent stock solution is the same as in Example 1 above. The gel point of the urolith adhesion inhibitor of this example was 42 ° C.

(Example 3)
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 1.0%
Far Celeran 1.8%
Locust bean gum 0.2%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

  As the carrageenan mixture, a mixture containing 70% by weight of iota type carrageenan and 30% by weight of copper type carrageenan (trade name NEWGELIN X-04123S: Chuo Foods Corporation) was used.

    The composition of the anti-adhesion agent stock solution is the same as in Example 1 above. The gel point of the urine stone adhesion inhibitor of this example was 45 ° C.

Example 4
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 1.5%
Far Celeran 1.4%
Locust bean gum 0.1%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

  The same carrageenan mixture as in Example 3 was used. The composition of the anti-adhesion agent stock solution is the same as in Example 1 above. The gel point of the urolith adhesion inhibitor of this example was 42 ° C.

(Example 5)
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 2.0%
Far Celeran 0.9%
Locust bean gum 0.1%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

  The same carrageenan mixture as in Example 1 was used. The composition of the anti-adhesion agent stock solution is the same as in Example 1 above. The gel point of the urolith adhesion inhibitor of this example was 42 ° C.

(Example 6)
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 2.5%
Far Celeran 0.5%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

  The same carrageenan mixture as in Example 1 was used. The composition of the anti-adhesion agent stock solution is the same as in Example 1 above. The gel point of the urine stone adhesion preventing agent of this example was 38 ° C.

(Example 7)
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 2.0%
Far Celeran 0.9%
Locust bean gum 0.1%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

    The same carrageenan mixture as in Example 3 was used. The composition of the anti-adhesion agent stock solution is the same as in Example 1 above. The gel point of the urine stone adhesion inhibitor of this example was 41 ° C.

(Example 8)
The composition of the urine stone adhesion preventive agent of the present example is as follows.
Ingredient Amount (wt%)
Stock solution 94.9%
Carrageenan mixture 2.5%
Far Celeran 0.5%
Ethylene diglycol 2.0%
Dibutylhydroxytoluene 0.1%

  The same carrageenan mixture as in Example 3 was used. The composition of the anti-adhesion agent stock solution is the same as in Example 1 above. The gel point of the urine stone adhesion preventing agent of this example was 38 ° C.

(Test example)
The above Examples 1 to 8 were tested for solubility in water. In the test method, four small urinals having a form similar to an actual urinal were prepared, and the urine stone adhesion preventive agents of Examples 1 to 8 were installed in the vicinity of the eye plates of each small urinal. It was set to be used 10 times, and about 2 L of washing water having a water temperature of 20 to 25 ° C. was poured at a rate of about once every 1 hour, and the change with time was observed.

  As a result of the test, the urinary stone adhesion preventive agent of Example 1 and Example 3 has a longer dissolution time in water of about 5 times compared with a commercially available urinary stone anti-adhesive agent containing a gelling agent, and dissolution delay The property was very excellent. Moreover, the dissolution time of Example 4 was also about 3 cultures of the commercially available urolith adhesion inhibitor, and the dissolution time of Example 2 was about 2 cultures of the commercially available urolith adhesion inhibitor. Furthermore, the dissolution time of Examples 5 to 8 was about 1.5 times that of a commercially available urine stone adhesion inhibitor.

  All examples were superior in dissolution delay compared to commercially available urine stone anti-adhesive agents, but the greater the amount of furceleran, the longer the dissolution time and the better dissolution delay. It was possible to confirm the excellent dissolution delay of furceleran.

(Other examples)
In the above examples, sucrose was used as the sugar component of the culture medium of Bacillus natto, but glucose could be used instead. It is also possible to use soy proteins other than soy peptone. In addition, the blending components and blending amounts in the urine stone adhesion preventing agent are not limited to the above examples, and various blending components can be used as already described.

  Furthermore, the present invention is mainly intended for a container for storing a urine stone adhesion preventive agent as described above, but the present invention is also applied to a container for slowly dissolving drugs other than the urine stone adhesion preventive agent. can do.

  The present invention relates to a container for storing a urine stone adhesion preventing agent for preventing urinary stones from adhering to a drainage part of a men's urinal and installing it in the drainage part, and a container for other slowly dissolving drugs. Can be widely applied to.

Claims (1)

Bacillus Natto or Bacillus natto culture, a gelling agent comprising a carrageenan mixture containing 50% by weight or more of iota-type carrageenan in the mixture , and a dissolution retardant comprising a far celerane that delays dissolution of the gelling agent. And a deodorizing agent comprising a vegetable extract .