JP3252000B2 - Urinary stone inhibitor and method for urinary stone prevention - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scale inhibitor for toilets and drainage pipes of toilets, and a method for preventing scale.

[0002]

2. Description of the Related Art With the spread of flush toilets, the environment of toilets has been improved. In particular, in the case of men's toilets, the pH of urine and washing water mixed in a toilet and a drainpipe rises, resulting in an increase in urine. The solubility of calcium phosphate formed by the reaction of calcium ions and phosphate ions in the inside decreases, and calcium phosphate precipitates together with organic substances in toilets and drain pipes to form urine stone. Since the urine stones that have adhered to them cannot be easily removed, their amount gradually increases, causing odors and clogging of drain pipes. For this reason, conventionally, a molded body composed of a solid acid, a sublimable substance, a surfactant, and a chelating agent has been installed in a toilet bowl, and a method of suppressing the pH of washing water to 5.0 to 8.5 or a metal chelating agent by the method described above. Aminopolycarboxylic acids such as NTA (Nitrilotriacetic acid) and EDTA (Ethylenediaminetetraacetic acid), or their sodium and ammonium salts, etc. are used in combination to convert calcium ions in urine into water-soluble metal compounds and dissolve uroliths There have been proposed methods and the like for improving the performance.

[0003]

However, in the case of a method of suppressing PH by placing a tablet of a solid acid that suppresses PH in a toilet bowl and dissolving the active ingredient with washing water, for example, a water-soluble acidic substance ( Sulfamic acid), a sublimable substance (paradichlorobenzene), and a non-ionic surfactant, the effective concentration of the urinary stone inhibitor in a urinal for men is 400 to 50.
When the content is 0 ppm or less, the effect is significantly reduced. Therefore, one (80-100 g) or two (about 50 g)
g / 1 tablet), and the urine stone prevention function by controlling the pH of the liquid by flowing a total of 4 to 5 liters of washing water at one time is not sufficient. Further, a combination use of a metal chelating agent, for example, a polyaminocarboxylic acid such as EDTA is also effective. However, since the dissolution amount at one time must be 400 to 500 ppm, the effective period is required unless the content in the tablet is extremely increased. Be shorter. In addition, the elution amount is 400 to 500
If the amount is not less than ppm, there is a problem that the activated sludge in the septic tank is adversely affected.

[0004]

Means for Solving the Problems The present inventor has made intensive studies to solve the above problems, and as a result, the mechanism of action is completely different from the conventional method of suppressing PH with an acid and improving the solubility with a metal chelate. Found a method of preventing the adhesion of urinary stones by different threshold effects. That is, phosphonic acid, an alkyl metal salt of phosphonic acid, or an ammonium salt of phosphonic acid have good stability against hydrolysis, and have a threshold effect in which precipitation from a supersaturated solution such as calcium is prevented by a chemical equivalent or less of an inhibitor. I found it great. In other words, it is intended to prevent the adhesion of uric stone mainly composed of calcium phosphate at a concentration much smaller than the calcium ion concentration in a stoichiometrically equivalent manner. When used at a low concentration, the rate of formation of the precipitate formed by the threshold effect is remarkably suppressed, and the crystal structure of the precipitate is distorted to prevent the adhesion of urolith. The present invention relates to a uremic inhibitor containing a phosphonic acid and / or an alkyl metal salt of a phosphonic acid and / or an ammonium salt of a phosphonic acid as an active ingredient, and a urolith preventer in which the urolith inhibitor is added or installed in a toilet bowl. Is the way. Examples of the phosphonic acid, an alkyl metal salt of the phosphonic acid, or an ammonium salt of the phosphonic acid which are the active ingredients of the present invention include aminotri (methylenephosphonic acid), 1-hydroxyethylidene-1,1-diphosphonic acid, ethylenediaminetetra (methylenephosphonic acid). Acid), diylenetriaminepenta (methylenephosphonic acid), and the like, but are not limited thereto.

[0005] As a method of flowing the active ingredient into the toilet so as to have a constant concentration, there are a method of disposing the active ingredient solidified by a usual method in a toilet bowl and dissolving the same with washing water. There is a method in which a component is used as an aqueous solution of a urinary stone inhibitor, and this is added by an automatic addition device so that the concentration in the washing water becomes constant. Solid urinary stone inhibitors contain 10-9 active ingredients
5% by weight, preferably 70 to 30% by weight, 10 to 90% by weight, preferably 70 to 30% by weight of a sublimable substance such as paradichlorobenzene, trialkyltrioxoic acid (an alkyl group having 3 to 6 carbon atoms). , Nonionic surfactants (HL
B12-20) 5-50% by weight, preferably 50-30% by weight
It is desirable to contain by weight. Other perfume as needed,
A coloring agent, a forming agent and the like can be added. Also, a small amount of an alkaline substance can be added for the purpose of improving the water solubility of the phosphonic acid. Further, polyethylene glycol may be used instead of the nonionic surfactant. In the present invention, the concentration of the active ingredient in one wash water is 1 to
Since the amounts of the sublimable substance, the water-soluble substance, and other additives may be adjusted to 100 ppm, the ratio for solidification is not limited to the description. The urinary stone inhibitor of the aqueous solution can be used only by making it a constant high-concentration aqueous solution of phosphonic acid, and its alkyl metal salt or ammonium salt. The concentration of the active ingredient in the washing water can be changed so as to be 1 to 100 ppm based on the washing water amount and the like. In addition, it is desirable to add a fragrance and a coloring agent as needed for the purpose of giving a refreshing feeling and a clean feeling.

[0006]

【Example】

(Examples 1 to 6 and Comparative Examples 1 to 8)
0 ml (per person), about 2 tap water
What was diluted at the rate of liter (one washing water amount)
An operation of adding 100 ml into a 140 ml glass bottle, adding each active ingredient to each concentration as shown in Table 1, and replacing the solution every 24 hours was repeated for one month, and the weight change of the bottle before and after the test was examined. As a result, as shown in Table 1, phosphonic acids and their sodium salts and ammonium salts showed excellent effects even at low concentrations.

[0007]

[Table 1]

(Note 1) At any concentration of 200 ppm or less, there was no change in pH before and after the addition of each component. The pH change before and after storage had the same tendency in each sample. (Note 2) Infrared spectroscopic analysis and fluorescent X-ray analysis were performed on the components adhering to the bottle and the actual urine stone, and the results were almost the same. (Note 3) Evaluation criteria (weight of urinary calculus / mmg) ：: 5 or less ○: 6 to 10 △: 11 to 20
×: 21 or more

Example 7 50 parts by weight of ethylenediaminetetra (methylenephosphonic acid), 10 of polyethylene glycol (molecular weight: 6000)
80 g of a mixture obtained by pulverizing and mixing 40 parts by weight of p-dichlorobenzene and 40 parts by weight of p-dichlorobenzene was subjected to pressure molding to prepare a semi-cylindrical molded body having a diameter of 50 mm. Example 8 50 g of ethylenediaminetetra (methylenephosphonic acid), 10 parts by weight of a nonionic surfactant (HLB 18.5), and 40 parts by weight of paradichlorobenzene were pulverized and mixed. A semi-cylindrical shaped body was prepared. Example 9 80 g of a mixture obtained by pulverizing and mixing 50 parts by weight of ethylenediaminetetra (methylenephosphonic acid), 7 parts by weight of a nonionic surfactant, 3 parts by weight of stearyl alcohol, and 40 parts by weight of p-dichlorobenzene was subjected to pressure molding to form a powder having a diameter of 50 mm. A semi-cylindrical shaped body was prepared. Example 10 80 g of a mixture obtained by pulverizing and mixing 50 parts by weight of ethylenediaminetetra (methylenephosphonic acid), 38 parts by weight of trialkyltrioxoic acid (the number of carbon atoms in the alkyl group is 3) and 2 parts by weight of calcium stearate was subjected to pressure molding. A 50 mm semi-cylindrical shaped body was prepared. Comparative Example 9 A commercially available molded article containing sulfamic acid as an active ingredient.

Each sample of Examples 7 to 10 (80
g), 4 liters of tap water was allowed to flow for 20 seconds, the water was stirred uniformly, and the phosphate ion concentration was measured to examine the solubility. As a result, as shown in Table 2, the active ingredient target concentration was 10 pp.
m or more.

[0011]

[Table 2]

The urinary stone deposits of each Example and Comparative Example were tested for about 3 months in a men's toilet used by about 50 people per day for about 3 months. The results are as shown in Table 3, and those of the examples had an extremely small amount of adhesion. The solid molded product was replaced with a new one every two weeks. For the liquid, a 1% by weight aqueous solution of the active ingredient was prepared, and the concentration of the active ingredient in the washing water was set to 10 ppm by an automatic addition device. Urinary stone adhesion is 30
A mesh stainless steel wire mesh (7 × 10 cm) was placed in the basin of the toilet flushing water and taken out after about 3 months.
The amount of weight increase after washing and drying with running water was defined as the urinary stone adhesion amount.

[0013]

[Table 3]

[0014]

EFFECT OF THE INVENTION The urinary stone inhibitor of the present invention is about 10 times more effective than the conventional urinary stone inhibitor. Further, since phosphonic acid and its alkyl metal salt or ammonium salt have a rust preventive action, there is no need to worry about corrosion of the drainage pipe of the washing water. Therefore, the present invention has great economic and public health significance.

Claims (2)

(57) [Claims] 1. A urinary stone inhibitor comprising phosphonic acid and / or an alkyl metal salt of phosphonic acid and / or an ammonium salt of phosphonic acid as an active ingredient. 2. A method for preventing or preventing urine, which comprises adding or installing the urinary stone inhibitor according to claim 1 in a toilet bowl.