KR101497357B1 - 신규한 바닐로이드 수용체 리간드 및 약제의 제조를 위한 이의 용도 - Google Patents
신규한 바닐로이드 수용체 리간드 및 약제의 제조를 위한 이의 용도 Download PDFInfo
- Publication number
- KR101497357B1 KR101497357B1 KR1020097023888A KR20097023888A KR101497357B1 KR 101497357 B1 KR101497357 B1 KR 101497357B1 KR 1020097023888 A KR1020097023888 A KR 1020097023888A KR 20097023888 A KR20097023888 A KR 20097023888A KR 101497357 B1 KR101497357 B1 KR 101497357B1
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- South Korea
- Prior art keywords
- butyl
- methyl
- formula
- compound
- trifluoromethyl
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- 0 *C*C(C(*)(*)c(c(**)c(*)c(*)c1*)c1S)=O Chemical compound *C*C(C(*)(*)c(c(**)c(*)c(*)c1*)c1S)=O 0.000 description 1
- VLYSMVBTVAWJAR-UHFFFAOYSA-N CC(C(NCc1ccc(C(F)(F)F)nc1N1CCC(C)CC1)=O)c(cc1Br)cc(Br)c1O Chemical compound CC(C(NCc1ccc(C(F)(F)F)nc1N1CCC(C)CC1)=O)c(cc1Br)cc(Br)c1O VLYSMVBTVAWJAR-UHFFFAOYSA-N 0.000 description 1
- LAINCCALWZHWME-UHFFFAOYSA-N CC(CC1)CCN1c1nc(C(F)(F)F)ccc1CNC(Cc(c(F)ccc1)c1F)=O Chemical compound CC(CC1)CCN1c1nc(C(F)(F)F)ccc1CNC(Cc(c(F)ccc1)c1F)=O LAINCCALWZHWME-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007018151A DE102007018151A1 (de) | 2007-04-16 | 2007-04-16 | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| DE102007018151.7 | 2007-04-16 | ||
| PCT/EP2008/002994 WO2008125337A2 (de) | 2007-04-16 | 2008-04-15 | Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100016594A KR20100016594A (ko) | 2010-02-12 |
| KR101497357B1 true KR101497357B1 (ko) | 2015-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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| EP (1) | EP2146962A2 (https=) |
| JP (1) | JP5557734B2 (https=) |
| KR (1) | KR101497357B1 (https=) |
| CN (1) | CN101687799B (https=) |
| BR (1) | BRPI0810031A2 (https=) |
| CA (1) | CA2683910A1 (https=) |
| CO (1) | CO6220938A2 (https=) |
| DE (1) | DE102007018151A1 (https=) |
| EC (1) | ECSP099693A (https=) |
| IL (1) | IL201506A0 (https=) |
| MX (1) | MX2009011139A (https=) |
| NZ (2) | NZ580381A (https=) |
| RU (1) | RU2487120C2 (https=) |
| WO (1) | WO2008125337A2 (https=) |
| ZA (1) | ZA200907096B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007313295A1 (en) * | 2006-10-18 | 2008-04-24 | Merck Sharp & Dohme Corp. | 2-hydroxy-2-phenyl/thiophenyl propionamides as androgen receptor modulators |
| WO2008110351A2 (en) * | 2007-03-15 | 2008-09-18 | Dompe' Pha.R.Ma S.P.A. | Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents |
| DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| WO2012158844A1 (en) * | 2011-05-17 | 2012-11-22 | Shionogi & Co., Ltd. | Heterocyclic compounds |
| JP2013014534A (ja) * | 2011-07-04 | 2013-01-24 | Daicel Corp | ベンゾイルギ酸化合物、及びその製造方法 |
| BR112014001714A2 (pt) | 2011-07-26 | 2017-02-14 | Gruenenthal Gmbh | derivados de carboxamida e ureia aromáticos bicíclicos substituídos como ligantes de receptor vaniloide |
| CA2842983A1 (en) * | 2011-07-26 | 2013-01-31 | Grunenthal Gmbh | Substituted heterocyclic aza derivatives |
| AR088702A1 (es) * | 2011-11-09 | 2014-06-25 | Gruenenthal Gmbh | Derivados de carboxamida y urea, basados en pirazolilo sustituido, que presentan una porcion fenilo sustituida con un grupo que contiene o como ligando de receptor vainilloide |
| AU2012334066A1 (en) * | 2011-11-09 | 2014-05-22 | Grunenthal Gmbh | Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an N-containing group as vanilloid receptor ligands |
| CA3106470A1 (en) | 2018-07-17 | 2020-01-23 | Nippon Chemiphar Co., Ltd. | T-type calcium channel blocker |
| JPWO2020203609A1 (https=) | 2019-03-29 | 2020-10-08 | ||
| RU2755206C1 (ru) | 2020-05-20 | 2021-09-14 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Средство пролонгированного анальгетического действия и лекарственный препарат на его основе |
| CN115417809A (zh) * | 2022-09-05 | 2022-12-02 | 天津药明康德新药开发有限公司 | 一种4,4-二吡咯-2,2-联吡啶的制备方法 |
| CN120860208A (zh) * | 2024-04-30 | 2025-10-31 | 中国人民解放军军事科学院军事医学研究院 | 刺激trpv1+感觉神经预防和治疗疾病 |
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| WO2001011966A1 (en) * | 1999-08-18 | 2001-02-22 | Aventis Cropscience Gmbh | Fungicides |
| WO2007039114A1 (en) * | 2005-09-20 | 2007-04-12 | Revotar Biopharmaceuticals Ag | Novel nitrocatechol derivatives having selectin ligand activity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209016C (zh) * | 1999-08-18 | 2005-07-06 | 阿方蒂农科有限公司 | 杀真菌剂 |
| ATE328868T1 (de) * | 2000-08-21 | 2006-06-15 | Pacific Corp | Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten |
| TWI239942B (en) * | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
| US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
| FR2836917B1 (fr) | 2002-03-11 | 2006-02-24 | Lipha | Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif |
| WO2003076392A2 (de) | 2002-03-14 | 2003-09-18 | Basf Aktiengesellschaft | Z-substituierte acrylamide, verfahren zu deren herstellung, sowie sie enthaltende mittel |
| TW200418806A (en) * | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
| US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| JP2006526660A (ja) * | 2003-06-05 | 2006-11-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Vr1レセプターのモジュレーター |
| KR100707123B1 (ko) | 2003-07-02 | 2007-04-16 | 그뤼넨탈 게엠베하 | 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물 |
| PT1708992E (pt) | 2004-01-22 | 2007-11-16 | Pfizer | Derivados de sulfonamida para o tratamento de doenças |
| WO2005073193A1 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| PE20110285A1 (es) | 2005-10-19 | 2011-06-04 | Gruenenthal Chemie | Derivados de sulfonamidofenil propionamida como ligandos del receptor vaniloide del subtipo 1 |
| DE102007018151A1 (de) | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
-
2007
- 2007-04-16 DE DE102007018151A patent/DE102007018151A1/de not_active Withdrawn
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2008
- 2008-04-15 JP JP2010503393A patent/JP5557734B2/ja not_active Expired - Fee Related
- 2008-04-15 CA CA002683910A patent/CA2683910A1/en not_active Abandoned
- 2008-04-15 MX MX2009011139A patent/MX2009011139A/es active IP Right Grant
- 2008-04-15 RU RU2009142024/04A patent/RU2487120C2/ru not_active IP Right Cessation
- 2008-04-15 BR BRPI0810031-4A2A patent/BRPI0810031A2/pt not_active IP Right Cessation
- 2008-04-15 CN CN200880020516.5A patent/CN101687799B/zh not_active Expired - Fee Related
- 2008-04-15 EP EP08735252A patent/EP2146962A2/de not_active Withdrawn
- 2008-04-15 KR KR1020097023888A patent/KR101497357B1/ko not_active Expired - Fee Related
- 2008-04-15 NZ NZ580381A patent/NZ580381A/en not_active IP Right Cessation
- 2008-04-15 US US12/103,198 patent/US8642775B2/en not_active Expired - Fee Related
- 2008-04-15 WO PCT/EP2008/002994 patent/WO2008125337A2/de not_active Ceased
- 2008-04-15 NZ NZ599254A patent/NZ599254A/xx not_active IP Right Cessation
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2009
- 2009-10-12 ZA ZA2009/07096A patent/ZA200907096B/en unknown
- 2009-10-14 IL IL201506A patent/IL201506A0/en unknown
- 2009-10-16 EC EC2009009693A patent/ECSP099693A/es unknown
- 2009-10-16 CO CO09115659A patent/CO6220938A2/es active IP Right Grant
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2011
- 2011-03-31 US US13/077,452 patent/US8791268B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001011966A1 (en) * | 1999-08-18 | 2001-02-22 | Aventis Cropscience Gmbh | Fungicides |
| WO2007039114A1 (en) * | 2005-09-20 | 2007-04-12 | Revotar Biopharmaceuticals Ag | Novel nitrocatechol derivatives having selectin ligand activity |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008125337A2 (de) | 2008-10-23 |
| EP2146962A2 (de) | 2010-01-27 |
| DE102007018151A1 (de) | 2008-10-23 |
| ZA200907096B (en) | 2013-03-27 |
| NZ599254A (en) | 2013-07-26 |
| CO6220938A2 (es) | 2010-11-19 |
| CN101687799A (zh) | 2010-03-31 |
| BRPI0810031A2 (pt) | 2014-10-14 |
| WO2008125337A3 (de) | 2009-02-26 |
| IL201506A0 (en) | 2010-05-31 |
| ECSP099693A (es) | 2009-11-30 |
| MX2009011139A (es) | 2009-10-30 |
| US20110184020A1 (en) | 2011-07-28 |
| KR20100016594A (ko) | 2010-02-12 |
| US8642775B2 (en) | 2014-02-04 |
| JP2010523726A (ja) | 2010-07-15 |
| JP5557734B2 (ja) | 2014-07-23 |
| NZ580381A (en) | 2012-05-25 |
| RU2487120C2 (ru) | 2013-07-10 |
| CA2683910A1 (en) | 2008-04-16 |
| CN101687799B (zh) | 2014-07-23 |
| US20080262039A1 (en) | 2008-10-23 |
| US8791268B2 (en) | 2014-07-29 |
| AU2008238245A1 (en) | 2008-10-23 |
| RU2009142024A (ru) | 2011-05-27 |
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