KR101490329B1 - 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물 - Google Patents

피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물 Download PDF

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KR101490329B1
KR101490329B1 KR20120113848A KR20120113848A KR101490329B1 KR 101490329 B1 KR101490329 B1 KR 101490329B1 KR 20120113848 A KR20120113848 A KR 20120113848A KR 20120113848 A KR20120113848 A KR 20120113848A KR 101490329 B1 KR101490329 B1 KR 101490329B1
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South Korea
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potassium salt
present
salt monohydrate
crystals
drying
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Korean (ko)
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KR20140047483A (ko
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김제학
김지한
이준광
유병욱
한남석
남경완
김창모
이주한
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보령제약 주식회사
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Priority to KR20120113848A priority Critical patent/KR101490329B1/ko
Application filed by 보령제약 주식회사 filed Critical 보령제약 주식회사
Priority to EP13845572.0A priority patent/EP2927226A4/en
Priority to IN3975DEN2015 priority patent/IN2015DN03975A/en
Priority to MYPI2015000875A priority patent/MY169064A/en
Priority to BR112015008170A priority patent/BR112015008170A2/pt
Priority to AU2013330603A priority patent/AU2013330603B2/en
Priority to CA2887056A priority patent/CA2887056C/en
Priority to PCT/KR2013/009097 priority patent/WO2014058268A1/ko
Priority to CN201380063465.5A priority patent/CN104854099B/zh
Priority to MX2015004573A priority patent/MX353635B/es
Priority to RU2015117524A priority patent/RU2613555C2/ru
Publication of KR20140047483A publication Critical patent/KR20140047483A/ko
Application granted granted Critical
Publication of KR101490329B1 publication Critical patent/KR101490329B1/ko
Priority to PH12015500794A priority patent/PH12015500794A1/en
Priority to SA515360275A priority patent/SA515360275B1/ar
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR20120113848A 2012-10-12 2012-10-12 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물 Expired - Fee Related KR101490329B1 (ko)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR20120113848A KR101490329B1 (ko) 2012-10-12 2012-10-12 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물
RU2015117524A RU2613555C2 (ru) 2012-10-12 2013-10-11 Моногидратный кристалл калиевой соли фимасартана, способ его получения и содержащая его фармакологическая композиция
MYPI2015000875A MY169064A (en) 2012-10-12 2013-10-11 Monohydrate crystal of fimasartan potassium salt, method for preparing same, and pharmacological composition comprising same
BR112015008170A BR112015008170A2 (pt) 2012-10-12 2013-10-11 cristal mono-hidratado de sal de potássio fimasartana, método para a preparação do mesmo e composição farmacológica compreendendo o mesmo
AU2013330603A AU2013330603B2 (en) 2012-10-12 2013-10-11 Monohydrate crystal of fimasartan potassium salt, method for preparing same, and pharmacological composition comprising same
CA2887056A CA2887056C (en) 2012-10-12 2013-10-11 Monohydrate crystal of fimasartan potassium salt, method for preparing same, and pharmacological composition comprising same
EP13845572.0A EP2927226A4 (en) 2012-10-12 2013-10-11 MONOHYDRATE CRYSTAL FROM FIMASARTANKALIUM SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACOLOGICAL COMPOSITION THEREWITH
CN201380063465.5A CN104854099B (zh) 2012-10-12 2013-10-11 非马沙坦钾盐的一水合物晶体、其制备方法及包含其的药物组合物
MX2015004573A MX353635B (es) 2012-10-12 2013-10-11 Cristal monohidratado de sal de potasio con fimasartan, método para preparar el mismo, y composición farmacéuticas que comprende el mismo.
IN3975DEN2015 IN2015DN03975A (cg-RX-API-DMAC7.html) 2012-10-12 2013-10-11
PCT/KR2013/009097 WO2014058268A1 (ko) 2012-10-12 2013-10-11 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물
PH12015500794A PH12015500794A1 (en) 2012-10-12 2015-04-10 Monohydrate crystal of fimasartan potassium salt, method for preparing same, and pharmacological composition comprising same
SA515360275A SA515360275B1 (ar) 2012-10-12 2015-04-12 بلورة مونوهيدرات لملح بوتاسيوم لفيماسارتان، طريقة لتحضيره، وتركيبة دوائية تشتمل عليه

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20120113848A KR101490329B1 (ko) 2012-10-12 2012-10-12 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물

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KR20140047483A KR20140047483A (ko) 2014-04-22
KR101490329B1 true KR101490329B1 (ko) 2015-02-04

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KR20120113848A Expired - Fee Related KR101490329B1 (ko) 2012-10-12 2012-10-12 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물

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EP (1) EP2927226A4 (cg-RX-API-DMAC7.html)
KR (1) KR101490329B1 (cg-RX-API-DMAC7.html)
CN (1) CN104854099B (cg-RX-API-DMAC7.html)
AU (1) AU2013330603B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015008170A2 (cg-RX-API-DMAC7.html)
CA (1) CA2887056C (cg-RX-API-DMAC7.html)
IN (1) IN2015DN03975A (cg-RX-API-DMAC7.html)
MX (1) MX353635B (cg-RX-API-DMAC7.html)
MY (1) MY169064A (cg-RX-API-DMAC7.html)
PH (1) PH12015500794A1 (cg-RX-API-DMAC7.html)
RU (1) RU2613555C2 (cg-RX-API-DMAC7.html)
SA (1) SA515360275B1 (cg-RX-API-DMAC7.html)
WO (1) WO2014058268A1 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102221856B1 (ko) 2020-10-12 2021-03-02 유니셀랩 주식회사 신규한 피마살탄 결정형의 다형체
KR20230062917A (ko) 2021-11-01 2023-05-09 그린케미칼 주식회사 피마살탄 일수화물 b형 결정다형 및 그 제조방법
KR20230062916A (ko) 2021-11-01 2023-05-09 그린케미칼 주식회사 피마살탄 무수물 a형 결정다형 및 그 제조방법

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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KR101545268B1 (ko) * 2015-02-05 2015-08-20 보령제약 주식회사 정제 및 이의 제조방법
CN105784867B (zh) * 2016-03-28 2019-01-01 北京睿创康泰医药研究院有限公司 用于分析非马沙坦有关物质的hplc方法及这些杂质作参比标准的用途
KR102247408B1 (ko) 2017-09-18 2021-05-03 보령제약 주식회사 피마살탄 프로드러그
KR102402501B1 (ko) * 2018-04-24 2022-05-26 (주)국전약품 피마살탄 트로메타민염 및 이를 포함하는 약제학적 조성물
KR20240146734A (ko) 2023-03-30 2024-10-08 (주) 에프엔지리서치 피마살탄의 신규 염 및 이의 제조방법

Citations (1)

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KR20040032639A (ko) * 2002-10-10 2004-04-17 보령제약 주식회사 피리미디논 화합물 및 이의 염의 삼수화물의 제조 방법

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KR100300566B1 (ko) * 1994-09-17 2001-11-22 조생현 피리미디논유도체와그의제조방법및용도
KR19990081093A (ko) * 1998-04-25 1999-11-15 조생현 피리미디논 화합물, 이를 함유하는 약제학적 조성물 및 이의제조방법
KR100617953B1 (ko) * 2000-03-23 2006-08-30 보령제약 주식회사 피리미디논 화합물 및 이의 염의 제조방법
WO2003024956A1 (en) * 2001-09-21 2003-03-27 Boryung Pharmaceutical Co., Ltd. Method for preparing pyrimidinone compound and pharmaceutically acceptable salts thereof
AU2011365756B2 (en) * 2011-04-12 2015-07-30 Boryung Pharmaceutical Co., Ltd. Antihypertensive pharmaceutical composition

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
KR20040032639A (ko) * 2002-10-10 2004-04-17 보령제약 주식회사 피리미디논 화합물 및 이의 염의 삼수화물의 제조 방법

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102221856B1 (ko) 2020-10-12 2021-03-02 유니셀랩 주식회사 신규한 피마살탄 결정형의 다형체
KR20230062917A (ko) 2021-11-01 2023-05-09 그린케미칼 주식회사 피마살탄 일수화물 b형 결정다형 및 그 제조방법
KR20230062916A (ko) 2021-11-01 2023-05-09 그린케미칼 주식회사 피마살탄 무수물 a형 결정다형 및 그 제조방법

Also Published As

Publication number Publication date
RU2613555C2 (ru) 2017-03-17
AU2013330603A1 (en) 2015-05-28
PH12015500794A1 (en) 2015-06-15
MX353635B (es) 2018-01-22
RU2015117524A (ru) 2016-12-10
KR20140047483A (ko) 2014-04-22
MX2015004573A (es) 2015-07-21
WO2014058268A1 (ko) 2014-04-17
CA2887056A1 (en) 2014-04-17
AU2013330603B2 (en) 2016-03-31
BR112015008170A2 (pt) 2017-07-04
MY169064A (en) 2019-02-12
EP2927226A4 (en) 2016-07-13
SA515360275B1 (ar) 2017-07-11
CA2887056C (en) 2017-09-05
EP2927226A1 (en) 2015-10-07
IN2015DN03975A (cg-RX-API-DMAC7.html) 2015-10-02
CN104854099A (zh) 2015-08-19
CN104854099B (zh) 2016-11-16

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Not in force date: 20250131