KR101486879B1 - 체외 치료요법을 통한 독성 인자의 제거 - Google Patents

체외 치료요법을 통한 독성 인자의 제거 Download PDF

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KR101486879B1
KR101486879B1 KR1020127022418A KR20127022418A KR101486879B1 KR 101486879 B1 KR101486879 B1 KR 101486879B1 KR 1020127022418 A KR1020127022418 A KR 1020127022418A KR 20127022418 A KR20127022418 A KR 20127022418A KR 101486879 B1 KR101486879 B1 KR 101486879B1
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toxin
blood
heparin
anthrax
solid substrate
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Korean (ko)
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KR20120123692A (ko
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키이스 맥크리어
로버트 에스. 워드
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엑스테라 메디컬 코퍼레이션
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020127022418A 2010-02-09 2011-02-09 체외 치료요법을 통한 독성 인자의 제거 Active KR101486879B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30282610P 2010-02-09 2010-02-09
US61/302,826 2010-02-09
PCT/US2011/024229 WO2011100354A1 (en) 2010-02-09 2011-02-09 Removal of virulence factors through extracorporeal therapy

Publications (2)

Publication Number Publication Date
KR20120123692A KR20120123692A (ko) 2012-11-09
KR101486879B1 true KR101486879B1 (ko) 2015-01-28

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KR1020127022418A Active KR101486879B1 (ko) 2010-02-09 2011-02-09 체외 치료요법을 통한 독성 인자의 제거

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Country Link
US (1) US20120305482A1 (enExample)
EP (1) EP2533828B1 (enExample)
JP (2) JP5774607B2 (enExample)
KR (1) KR101486879B1 (enExample)
CN (1) CN102791307B (enExample)
AU (1) AU2011215942B8 (enExample)
CA (1) CA2786550C (enExample)
ES (1) ES2728122T3 (enExample)
WO (1) WO2011100354A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029958T2 (en) 2005-12-13 2017-04-28 Exthera Medical Corp A method for removing extracellular microbes, inflammatory cells or inflammatory proteins from the body
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
JP5925693B2 (ja) 2009-12-01 2016-05-25 エクステラ・メディカル・コーポレーション 表面固定した多糖類を用いた、血液からのサイトカイン除去法
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
ES2996347T3 (en) * 2012-06-29 2025-02-12 Cytosorbents Corp Biocompatible sorbent
EP3013445B1 (en) * 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
JP6806563B2 (ja) 2013-11-08 2021-01-06 エクステラ・メディカル・コーポレーション 吸着媒体を使用する感染症の診断法
KR20170020749A (ko) 2014-04-24 2017-02-24 엑스테라 메디컬 코퍼레이션 고유속을 이용한 혈액으로부터 세균의 제거방법
JP7100454B2 (ja) 2014-09-22 2022-07-13 エクスセラ メディカル コーポレイション 装着型血液潅流デバイス
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
US10822461B2 (en) 2017-10-05 2020-11-03 Fresenius Medical Care Holdings, Inc. Polysulfone-urethane copolymer, membranes and products incorporating same, and methods for making and using same
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
KR20220009400A (ko) 2019-05-16 2022-01-24 엑스테라 메디컬 코퍼레이션 내피 글리코칼릭스 구조의 조절 방법
EP4251230A1 (en) * 2020-11-30 2023-10-04 Alteco Medical AB Device for binding and separation of at least one component from a body fluid
HUP2200216A1 (hu) 2022-06-15 2023-12-28 Captec Medical Kft Nagy teljesítményû, immun-affinitáson alapuló, extrakorporális patogén csapda

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000334037A (ja) 1999-04-12 2000-12-05 B Braun Melsungen Ag 血液、血漿または血清からのエンベロープ保有ウイルスの除去
WO2008157570A2 (en) 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood
US20090136586A1 (en) 2005-12-13 2009-05-28 Exthera Ab Method for Extracorporeal Removal of a Pathogenic Microbe, an Inflammatory Cell or an Inflammatory Protein From Blood

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803183B2 (en) * 2002-07-18 2004-10-12 Clarigen, Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
RU2353399C2 (ru) * 2003-01-17 2009-04-27 Этлон Медикал, Инк. Способ удаления вирусов из крови посредством лектин-аффинного гемодиализа
CA2581883A1 (en) * 2004-09-27 2006-04-06 Technion Research & Development Foundation Ltd. Novel antimicrobial agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000334037A (ja) 1999-04-12 2000-12-05 B Braun Melsungen Ag 血液、血漿または血清からのエンベロープ保有ウイルスの除去
US20090136586A1 (en) 2005-12-13 2009-05-28 Exthera Ab Method for Extracorporeal Removal of a Pathogenic Microbe, an Inflammatory Cell or an Inflammatory Protein From Blood
WO2008157570A2 (en) 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood

Also Published As

Publication number Publication date
CN102791307A (zh) 2012-11-21
JP5774607B2 (ja) 2015-09-09
CA2786550A1 (en) 2011-08-18
AU2011215942B8 (en) 2014-02-13
CA2786550C (en) 2018-03-13
KR20120123692A (ko) 2012-11-09
JP2015131831A (ja) 2015-07-23
EP2533828A1 (en) 2012-12-19
CN102791307B (zh) 2016-05-18
AU2011215942A1 (en) 2012-07-26
EP2533828B1 (en) 2019-02-27
JP2013518687A (ja) 2013-05-23
WO2011100354A1 (en) 2011-08-18
AU2011215942B2 (en) 2014-01-30
ES2728122T3 (es) 2019-10-22
US20120305482A1 (en) 2012-12-06

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