CN102791307B - 通过体外疗法除去毒力因子 - Google Patents

通过体外疗法除去毒力因子 Download PDF

Info

Publication number
CN102791307B
CN102791307B CN201180008828.6A CN201180008828A CN102791307B CN 102791307 B CN102791307 B CN 102791307B CN 201180008828 A CN201180008828 A CN 201180008828A CN 102791307 B CN102791307 B CN 102791307B
Authority
CN
China
Prior art keywords
toxin
blood
heparin
purposes
anthrax
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180008828.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN102791307A (zh
Inventor
K·麦克雷
R·S·沃德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exthera Medical Corp
Original Assignee
Exthera Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exthera Medical Corp filed Critical Exthera Medical Corp
Publication of CN102791307A publication Critical patent/CN102791307A/zh
Application granted granted Critical
Publication of CN102791307B publication Critical patent/CN102791307B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201180008828.6A 2010-02-09 2011-02-09 通过体外疗法除去毒力因子 Active CN102791307B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30282610P 2010-02-09 2010-02-09
US61/302,826 2010-02-09
PCT/US2011/024229 WO2011100354A1 (en) 2010-02-09 2011-02-09 Removal of virulence factors through extracorporeal therapy

Publications (2)

Publication Number Publication Date
CN102791307A CN102791307A (zh) 2012-11-21
CN102791307B true CN102791307B (zh) 2016-05-18

Family

ID=43975201

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180008828.6A Active CN102791307B (zh) 2010-02-09 2011-02-09 通过体外疗法除去毒力因子

Country Status (9)

Country Link
US (1) US20120305482A1 (enExample)
EP (1) EP2533828B1 (enExample)
JP (2) JP5774607B2 (enExample)
KR (1) KR101486879B1 (enExample)
CN (1) CN102791307B (enExample)
AU (1) AU2011215942B8 (enExample)
CA (1) CA2786550C (enExample)
ES (1) ES2728122T3 (enExample)
WO (1) WO2011100354A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844895B2 (en) 2014-04-24 2023-12-19 Exthera Medical Corporation Method for removing bacteria from blood using high flow rate

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029958T2 (en) 2005-12-13 2017-04-28 Exthera Medical Corp A method for removing extracellular microbes, inflammatory cells or inflammatory proteins from the body
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
JP5925693B2 (ja) 2009-12-01 2016-05-25 エクステラ・メディカル・コーポレーション 表面固定した多糖類を用いた、血液からのサイトカイン除去法
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
ES2996347T3 (en) * 2012-06-29 2025-02-12 Cytosorbents Corp Biocompatible sorbent
EP3013445B1 (en) * 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
JP6806563B2 (ja) 2013-11-08 2021-01-06 エクステラ・メディカル・コーポレーション 吸着媒体を使用する感染症の診断法
JP7100454B2 (ja) 2014-09-22 2022-07-13 エクスセラ メディカル コーポレイション 装着型血液潅流デバイス
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
US10822461B2 (en) 2017-10-05 2020-11-03 Fresenius Medical Care Holdings, Inc. Polysulfone-urethane copolymer, membranes and products incorporating same, and methods for making and using same
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
KR20220009400A (ko) 2019-05-16 2022-01-24 엑스테라 메디컬 코퍼레이션 내피 글리코칼릭스 구조의 조절 방법
EP4251230A1 (en) * 2020-11-30 2023-10-04 Alteco Medical AB Device for binding and separation of at least one component from a body fluid
HUP2200216A1 (hu) 2022-06-15 2023-12-28 Captec Medical Kft Nagy teljesítményû, immun-affinitáson alapuló, extrakorporális patogén csapda

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014022A1 (en) * 2002-07-18 2004-01-22 Clarigen Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
CN101065131A (zh) * 2004-09-27 2007-10-31 技术研究及发展基金有限公司 新的抗微生物剂
CN101124315A (zh) * 2003-01-17 2008-02-13 伊势龙医学股份有限公司 利用凝集素亲和性血液透析去除血液中病毒的方法
WO2008157570A2 (en) * 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19916352A1 (de) * 1999-04-12 2000-10-19 Braun Melsungen Ag Entfernung von hüllehaltigen Viren aus Blut, Plasma oder Serum
HUE029958T2 (en) * 2005-12-13 2017-04-28 Exthera Medical Corp A method for removing extracellular microbes, inflammatory cells or inflammatory proteins from the body

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014022A1 (en) * 2002-07-18 2004-01-22 Clarigen Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
CN101124315A (zh) * 2003-01-17 2008-02-13 伊势龙医学股份有限公司 利用凝集素亲和性血液透析去除血液中病毒的方法
CN101065131A (zh) * 2004-09-27 2007-10-31 技术研究及发展基金有限公司 新的抗微生物剂
WO2008157570A2 (en) * 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogens;Richard Thomas and Tim Brooks;《Journal of Medical Microbiology》;20041231;833-840 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844895B2 (en) 2014-04-24 2023-12-19 Exthera Medical Corporation Method for removing bacteria from blood using high flow rate

Also Published As

Publication number Publication date
CN102791307A (zh) 2012-11-21
JP5774607B2 (ja) 2015-09-09
CA2786550A1 (en) 2011-08-18
AU2011215942B8 (en) 2014-02-13
CA2786550C (en) 2018-03-13
KR101486879B1 (ko) 2015-01-28
KR20120123692A (ko) 2012-11-09
JP2015131831A (ja) 2015-07-23
EP2533828A1 (en) 2012-12-19
AU2011215942A1 (en) 2012-07-26
EP2533828B1 (en) 2019-02-27
JP2013518687A (ja) 2013-05-23
WO2011100354A1 (en) 2011-08-18
AU2011215942B2 (en) 2014-01-30
ES2728122T3 (es) 2019-10-22
US20120305482A1 (en) 2012-12-06

Similar Documents

Publication Publication Date Title
CN102791307B (zh) 通过体外疗法除去毒力因子
US11123466B2 (en) Methods for removing cytokines from blood with surface immobilized polysaccharides
US10537280B2 (en) Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
AU2014277852B2 (en) Method for removing cytokines from blood with surface immobilized polysaccharides
HK1176572B (en) Removal of virulence factors through extracorporeal therapy
HK1176572A (en) Removal of virulence factors through extracorporeal therapy
HK1230116A1 (en) Method for removing cytokines from blood with surface immobilized polysaccharides
HK1230116B (zh) 使用固定於表面的多糖从血液中去除细胞因子的方法
HK1177151B (en) Method for removing cytokines from blood with surface immobilized polysaccharides

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: American California

Applicant after: EXTHERA MEDICAL CORP

Address before: American California

Applicant before: Exthera Medical, LLC

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: EXTHERA MEDICAL LLC TO: EXTHERA MEDICAL CORP.

C14 Grant of patent or utility model
GR01 Patent grant