CN102791307B - 通过体外疗法除去毒力因子 - Google Patents

通过体外疗法除去毒力因子 Download PDF

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Publication number
CN102791307B
CN102791307B CN201180008828.6A CN201180008828A CN102791307B CN 102791307 B CN102791307 B CN 102791307B CN 201180008828 A CN201180008828 A CN 201180008828A CN 102791307 B CN102791307 B CN 102791307B
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CN
China
Prior art keywords
toxin
blood
heparin
purposes
anthrax
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CN201180008828.6A
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English (en)
Chinese (zh)
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CN102791307A (zh
Inventor
K·麦克雷
R·S·沃德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EXTHERA MEDICAL LLC
Exthera Medical Corp
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EXTHERA MEDICAL LLC
Exthera Medical Corp
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Publication of CN102791307A publication Critical patent/CN102791307A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201180008828.6A 2010-02-09 2011-02-09 通过体外疗法除去毒力因子 Active CN102791307B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30282610P 2010-02-09 2010-02-09
US61/302,826 2010-02-09
PCT/US2011/024229 WO2011100354A1 (en) 2010-02-09 2011-02-09 Removal of virulence factors through extracorporeal therapy

Publications (2)

Publication Number Publication Date
CN102791307A CN102791307A (zh) 2012-11-21
CN102791307B true CN102791307B (zh) 2016-05-18

Family

ID=43975201

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180008828.6A Active CN102791307B (zh) 2010-02-09 2011-02-09 通过体外疗法除去毒力因子

Country Status (9)

Country Link
US (1) US20120305482A1 (enExample)
EP (1) EP2533828B1 (enExample)
JP (2) JP5774607B2 (enExample)
KR (1) KR101486879B1 (enExample)
CN (1) CN102791307B (enExample)
AU (1) AU2011215942B8 (enExample)
CA (1) CA2786550C (enExample)
ES (1) ES2728122T3 (enExample)
WO (1) WO2011100354A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844895B2 (en) 2014-04-24 2023-12-19 Exthera Medical Corporation Method for removing bacteria from blood using high flow rate

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007069983A1 (en) 2005-12-13 2007-06-21 Exthera Ab Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
JP5925693B2 (ja) 2009-12-01 2016-05-25 エクステラ・メディカル・コーポレーション 表面固定した多糖類を用いた、血液からのサイトカイン除去法
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
ES2647577T3 (es) 2012-06-13 2017-12-22 Exthera Medical Corporation Uso de heparina y carbohidratos para tratar el cáncer
US20150335576A1 (en) 2012-06-29 2015-11-26 Cytosorbents Corporation Methods of using polymers
CN105339067A (zh) * 2013-06-24 2016-02-17 艾克塞拉医疗公司 含有涂覆甘露糖的基质的血液过滤系统
EP3065796B1 (en) * 2013-11-08 2020-04-15 ExThera Medical Corporation Methods for diagnosing infectious diseases using adsorption media
CA2959975A1 (en) 2014-09-22 2016-03-31 Exthera Medical Corporation Wearable hemoperfusion device
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
US10822461B2 (en) 2017-10-05 2020-11-03 Fresenius Medical Care Holdings, Inc. Polysulfone-urethane copolymer, membranes and products incorporating same, and methods for making and using same
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
CN113825517A (zh) * 2019-05-16 2021-12-21 艾克塞拉医疗公司 调节内皮糖萼结构的方法
JP2023550942A (ja) * 2020-11-30 2023-12-06 アルテコ メディカル アクティエボラーグ 体液から少なくとも１つの成分を結合及び分離するための装置
HUP2200216A1 (hu) 2022-06-15 2023-12-28 Captec Medical Kft Nagy teljesítményû, immun-affinitáson alapuló, extrakorporális patogén csapda

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014022A1 (en) * 2002-07-18 2004-01-22 Clarigen Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
CN101065131A (zh) * 2004-09-27 2007-10-31 技术研究及发展基金有限公司 新的抗微生物剂
CN101124315A (zh) * 2003-01-17 2008-02-13 伊势龙医学股份有限公司 利用凝集素亲和性血液透析去除血液中病毒的方法
WO2008157570A2 (en) * 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19916352A1 (de) * 1999-04-12 2000-10-19 Braun Melsungen Ag Entfernung von hüllehaltigen Viren aus Blut, Plasma oder Serum
WO2007069983A1 (en) * 2005-12-13 2007-06-21 Exthera Ab Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014022A1 (en) * 2002-07-18 2004-01-22 Clarigen Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
CN101124315A (zh) * 2003-01-17 2008-02-13 伊势龙医学股份有限公司 利用凝集素亲和性血液透析去除血液中病毒的方法
CN101065131A (zh) * 2004-09-27 2007-10-31 技术研究及发展基金有限公司 新的抗微生物剂
WO2008157570A2 (en) * 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogens;Richard Thomas and Tim Brooks;《Journal of Medical Microbiology》;20041231;833-840 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844895B2 (en) 2014-04-24 2023-12-19 Exthera Medical Corporation Method for removing bacteria from blood using high flow rate

Also Published As

Publication number Publication date
ES2728122T3 (es) 2019-10-22
US20120305482A1 (en) 2012-12-06
EP2533828A1 (en) 2012-12-19
AU2011215942A1 (en) 2012-07-26
CN102791307A (zh) 2012-11-21
KR20120123692A (ko) 2012-11-09
WO2011100354A1 (en) 2011-08-18
AU2011215942B2 (en) 2014-01-30
CA2786550C (en) 2018-03-13
JP2013518687A (ja) 2013-05-23
JP5774607B2 (ja) 2015-09-09
AU2011215942B8 (en) 2014-02-13
EP2533828B1 (en) 2019-02-27
KR101486879B1 (ko) 2015-01-28
JP2015131831A (ja) 2015-07-23
CA2786550A1 (en) 2011-08-18

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Address after: American California

Applicant after: EXTHERA MEDICAL CORP

Address before: American California

Applicant before: Exthera Medical, LLC

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C14 Grant of patent or utility model
GR01 Patent grant