KR101402398B1 - 퀴놀리논 유도체 및 이의 제약 조성물 - Google Patents

퀴놀리논 유도체 및 이의 제약 조성물 Download PDF

Info

Publication number
KR101402398B1
KR101402398B1 KR1020087031819A KR20087031819A KR101402398B1 KR 101402398 B1 KR101402398 B1 KR 101402398B1 KR 1020087031819 A KR1020087031819 A KR 1020087031819A KR 20087031819 A KR20087031819 A KR 20087031819A KR 101402398 B1 KR101402398 B1 KR 101402398B1
Authority
KR
South Korea
Prior art keywords
hydroxy
ylamino
quinolin
indan
diethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020087031819A
Other languages
English (en)
Korean (ko)
Other versions
KR20090023651A (ko
Inventor
올리비에르 로세
스테파니 모니에르
장-루이 레베르
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0613156A external-priority patent/GB0613156D0/en
Priority claimed from GB0613159A external-priority patent/GB0613159D0/en
Priority claimed from GB0613158A external-priority patent/GB0613158D0/en
Priority claimed from GB0613160A external-priority patent/GB0613160D0/en
Priority claimed from EP06117129A external-priority patent/EP1878722A1/en
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20090023651A publication Critical patent/KR20090023651A/ko
Application granted granted Critical
Publication of KR101402398B1 publication Critical patent/KR101402398B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020087031819A 2006-06-30 2007-07-02 퀴놀리논 유도체 및 이의 제약 조성물 Active KR101402398B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
GB0613158.5 2006-06-30
GB0613156A GB0613156D0 (en) 2006-06-30 2006-06-30 Organic Compounds
GB0613159A GB0613159D0 (en) 2006-06-30 2006-06-30 Organic Compounds
GB0613159.3 2006-06-30
GB0613156.9 2006-06-30
GB0613158A GB0613158D0 (en) 2006-06-30 2006-06-30 Organic compounds
GB0613160.1 2006-06-30
GB0613160A GB0613160D0 (en) 2006-06-30 2006-06-30 Organic Compounds
EP06117129A EP1878722A1 (en) 2006-07-13 2006-07-13 Quinolinone derivatives and their pharmaceutical compositions
EP06117129.4 2006-07-13
PCT/EP2007/056632 WO2008000839A1 (en) 2006-06-30 2007-07-02 Quinolinone derivatives and their pharmaceutical compositions

Publications (2)

Publication Number Publication Date
KR20090023651A KR20090023651A (ko) 2009-03-05
KR101402398B1 true KR101402398B1 (ko) 2014-06-03

Family

ID=38610531

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087031819A Active KR101402398B1 (ko) 2006-06-30 2007-07-02 퀴놀리논 유도체 및 이의 제약 조성물

Country Status (28)

Country Link
US (2) US8198450B2 (enExample)
EP (1) EP2044025B1 (enExample)
JP (1) JP5253392B2 (enExample)
KR (1) KR101402398B1 (enExample)
CN (1) CN101479245B (enExample)
AU (1) AU2007264946B2 (enExample)
BR (1) BRPI0713951B8 (enExample)
CA (1) CA2654801C (enExample)
CY (3) CY1113733T1 (enExample)
DK (1) DK2044025T3 (enExample)
ES (1) ES2396987T3 (enExample)
FI (2) FIC20200047I1 (enExample)
FR (2) FR20C1054I1 (enExample)
HR (1) HRP20121074T1 (enExample)
HU (2) HUS2000043I1 (enExample)
IL (1) IL195796A (enExample)
LT (2) LTC2044025I2 (enExample)
LU (2) LUC00185I2 (enExample)
MA (1) MA30540B1 (enExample)
MX (1) MX2008016542A (enExample)
MY (1) MY150468A (enExample)
NO (3) NO341709B1 (enExample)
NZ (1) NZ573292A (enExample)
PL (1) PL2044025T3 (enExample)
PT (1) PT2044025E (enExample)
SI (1) SI2044025T1 (enExample)
WO (1) WO2008000839A1 (enExample)
ZA (1) ZA200809948B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1860192A1 (en) 1996-09-17 2007-11-28 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for treating intracellular diseases
KR20120120453A (ko) 2007-09-05 2012-11-01 화이자 리미티드 Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
AU2014229361B2 (en) 2013-03-14 2016-08-04 Novartis Ag Deamorphization of spray-dried formulations via spray-blending
EP3347345B1 (en) 2015-09-29 2019-07-31 Inke, S.A. Mixed solvate of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one l-tartrate
CN110724095B (zh) * 2019-09-12 2023-06-09 上海方予健康医药科技有限公司 一种茚达特罗乙酸盐的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002045703A2 (en) * 2000-12-04 2002-06-13 Novartis Ag Mixtures or organic compounds for the treatmentof airway diseases

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05202301A (ja) * 1991-08-29 1993-08-10 Yamamoto Chem Inc ２−アニリノ−３−メチル−６−（Ｎ−ｎ−ブチル−Ｎ−シクロヘキシルアミノ）フルオランの結晶変態、その製造方法及びこの結晶変態を含有する記録材料
EP0688871A3 (en) * 1994-06-24 1998-07-08 Quest International B.V. Preparation of phytosphingosine derivative
FR2777279B1 (fr) * 1998-04-08 2004-08-13 Hoechst Marion Roussel Inc Nouvelles formes cristallines du 1s-[1alpha(2s*,3r*), 9 alpha] 6,10-dioxo-n-(2-ethoxy-5-oxo-tetrahydro-3-furanyl) -9[[(1-isoquinolyl)carbonyl]amino]octohydro-6h-pyridazino [1,2-a][1,2]diazepine-1-carboxamide
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
GB0127430D0 (en) 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
US7417051B2 (en) 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7250426B2 (en) 2002-11-29 2007-07-31 Boehringer Ingelheim Pharma Gmbh & Co Kg Tiotropium-containing pharmaceutical combination for inhalation
GB0303910D0 (en) 2003-02-20 2003-03-26 Merck Sharp & Dohme Therapeutic agents
TWI324150B (en) 2003-02-28 2010-05-01 Novartis Ag Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
PE20050211A1 (es) 2003-04-02 2005-04-27 Novartis Ag Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas
CA2521271C (en) 2003-04-04 2011-01-04 Novartis Ag Quinoline-2-one-derivatives for the treatment of airways diseases
JP2005343889A (ja) 2004-05-06 2005-12-15 Taisho Pharmaceut Co Ltd イミダゾピリジン誘導体
GB0411056D0 (en) * 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GB0413960D0 (en) 2004-06-22 2004-07-28 Novartis Ag Organic compounds
DK1869049T3 (da) 2005-03-21 2009-05-18 Lilly Co Eli Imidazopyridazinforbindelser
GB0511065D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
EP1910369A1 (en) 2005-07-29 2008-04-16 Astellas Pharma Inc. Fused heterocycles as lck inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002045703A2 (en) * 2000-12-04 2002-06-13 Novartis Ag Mixtures or organic compounds for the treatmentof airway diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
The Practice of Medicinal Chemistry. 2nd Edition. 2003. pp. 601-615 *
The Practice of Medicinal Chemistry. 2nd Edition. 2003. pp. 601-615*

Also Published As

Publication number Publication date
MA30540B1 (fr) 2009-06-01
AU2007264946A1 (en) 2008-01-03
ES2396987T3 (es) 2013-03-01
HUS2000043I1 (hu) 2020-12-28
LUC00188I2 (enExample) 2024-07-01
CA2654801A1 (en) 2008-01-03
PL2044025T3 (pl) 2013-02-28
ZA200809948B (en) 2009-05-25
NO2020041I1 (no) 2020-11-23
NO2020044I1 (no) 2020-12-07
HUS2000053I1 (hu) 2020-12-28
BRPI0713951A2 (pt) 2012-12-04
AU2007264946B2 (en) 2011-01-20
FR20C1063I1 (fr) 2021-01-22
BRPI0713951B8 (pt) 2021-05-25
CA2654801C (en) 2014-08-19
CN101479245B (zh) 2013-05-22
JP5253392B2 (ja) 2013-07-31
FIC20200047I1 (fi) 2020-11-27
FR20C1054I1 (fr) 2020-12-25
EP2044025A1 (en) 2009-04-08
NZ573292A (en) 2011-03-31
KR20090023651A (ko) 2009-03-05
CY1113733T1 (el) 2016-06-22
CY2020041I1 (el) 2021-03-12
US20090325912A1 (en) 2009-12-31
FIC20200050I1 (fi) 2020-12-16
LTPA2020535I1 (lt) 2020-12-28
CN101479245A (zh) 2009-07-08
HK1127597A1 (en) 2009-10-02
HRP20121074T1 (hr) 2013-01-31
JP2009541455A (ja) 2009-11-26
US8198450B2 (en) 2012-06-12
CY2020038I2 (el) 2021-03-12
SI2044025T1 (sl) 2013-01-31
IL195796A0 (en) 2009-09-01
BRPI0713951B1 (pt) 2019-08-13
LUC00185I2 (enExample) 2024-07-01
CY2020041I2 (el) 2021-03-12
DK2044025T3 (da) 2013-01-14
US20120316142A1 (en) 2012-12-13
WO2008000839A1 (en) 2008-01-03
CY2020038I1 (el) 2021-03-12
IL195796A (en) 2016-03-31
MY150468A (en) 2014-01-30
MX2008016542A (es) 2009-01-19
PT2044025E (pt) 2012-12-17
NO20090312L (no) 2009-01-28
LTPA2020538I1 (lt) 2021-01-11
NO341709B1 (no) 2018-01-02
LTC2044025I2 (lt) 2022-10-10
EP2044025B1 (en) 2012-10-03

Similar Documents

Publication Publication Date Title
AU2004226824B2 (en) Quinoline-2-one-derivatives for the treatment of airways diseases
KR101402398B1 (ko) 퀴놀리논 유도체 및 이의 제약 조성물
KR20090049615A (ko) 베타-아드레날린수용체 효능제로서의 인단-２-일아미노-히드록시에틸-퀴놀리논 말레에이트 유도체의 다형체 결정형
KR100688371B1 (ko) 공지된 티오펜카르복실산 도데카히드로시클로펜타 (ａ)페난트레닐 에스테르의 다형체
RU2449991C2 (ru) Производные хинолинона и содержащие их фармацевтические композиции
KR20090051110A (ko) (ｒ)-３-(２-히드록시-２,２-디페닐-아세톡시)-１-(이속사졸-３-일카르바모일-메틸)-１-아조니아-비시클로-[２.２.２]옥탄 브로마이드의 다형체
HK1127597B (en) Quinolinone derivatives and their pharmaceutical compositions
EP1878722A1 (en) Quinolinone derivatives and their pharmaceutical compositions

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20081229

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20120627

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20131028

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20140430

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20140526

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20140526

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20170504

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20170504

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20180427

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20180427

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20190429

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20190429

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20210428

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20220427

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20230427

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20240430

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20250428

Start annual number: 12

End annual number: 12