KR101402398B1 - 퀴놀리논 유도체 및 이의 제약 조성물 - Google Patents

퀴놀리논 유도체 및 이의 제약 조성물 Download PDF

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Publication number
KR101402398B1
KR101402398B1 KR1020087031819A KR20087031819A KR101402398B1 KR 101402398 B1 KR101402398 B1 KR 101402398B1 KR 1020087031819 A KR1020087031819 A KR 1020087031819A KR 20087031819 A KR20087031819 A KR 20087031819A KR 101402398 B1 KR101402398 B1 KR 101402398B1
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KR
South Korea
Prior art keywords
hydroxy
ylamino
quinolin
indan
diethyl
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KR1020087031819A
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English (en)
Korean (ko)
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KR20090023651A (ko
Inventor
올리비에르 로세
스테파니 모니에르
장-루이 레베르
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노파르티스 아게
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Filing date
Publication date
Priority claimed from GB0613158A external-priority patent/GB0613158D0/en
Priority claimed from GB0613159A external-priority patent/GB0613159D0/en
Priority claimed from GB0613156A external-priority patent/GB0613156D0/en
Priority claimed from GB0613160A external-priority patent/GB0613160D0/en
Priority claimed from EP06117129A external-priority patent/EP1878722A1/en
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20090023651A publication Critical patent/KR20090023651A/ko
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Publication of KR101402398B1 publication Critical patent/KR101402398B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020087031819A 2006-06-30 2007-07-02 퀴놀리논 유도체 및 이의 제약 조성물 Active KR101402398B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
GB0613158A GB0613158D0 (en) 2006-06-30 2006-06-30 Organic compounds
GB0613159A GB0613159D0 (en) 2006-06-30 2006-06-30 Organic Compounds
GB0613156.9 2006-06-30
GB0613159.3 2006-06-30
GB0613160.1 2006-06-30
GB0613158.5 2006-06-30
GB0613156A GB0613156D0 (en) 2006-06-30 2006-06-30 Organic Compounds
GB0613160A GB0613160D0 (en) 2006-06-30 2006-06-30 Organic Compounds
EP06117129.4 2006-07-13
EP06117129A EP1878722A1 (en) 2006-07-13 2006-07-13 Quinolinone derivatives and their pharmaceutical compositions
PCT/EP2007/056632 WO2008000839A1 (en) 2006-06-30 2007-07-02 Quinolinone derivatives and their pharmaceutical compositions

Publications (2)

Publication Number Publication Date
KR20090023651A KR20090023651A (ko) 2009-03-05
KR101402398B1 true KR101402398B1 (ko) 2014-06-03

Family

ID=38610531

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Application Number Title Priority Date Filing Date
KR1020087031819A Active KR101402398B1 (ko) 2006-06-30 2007-07-02 퀴놀리논 유도체 및 이의 제약 조성물

Country Status (29)

Country Link
US (2) US8198450B2 (enExample)
EP (1) EP2044025B1 (enExample)
JP (1) JP5253392B2 (enExample)
KR (1) KR101402398B1 (enExample)
CN (1) CN101479245B (enExample)
AU (1) AU2007264946B2 (enExample)
BE (2) BE2020C550I2 (enExample)
BR (1) BRPI0713951B8 (enExample)
CA (1) CA2654801C (enExample)
CY (3) CY1113733T1 (enExample)
DK (1) DK2044025T3 (enExample)
ES (1) ES2396987T3 (enExample)
FI (2) FIC20200047I1 (enExample)
FR (2) FR20C1054I1 (enExample)
HR (1) HRP20121074T1 (enExample)
HU (2) HUS2000043I1 (enExample)
IL (1) IL195796A (enExample)
LT (2) LTC2044025I2 (enExample)
LU (2) LUC00185I2 (enExample)
MA (1) MA30540B1 (enExample)
MX (1) MX2008016542A (enExample)
MY (1) MY150468A (enExample)
NO (3) NO341709B1 (enExample)
NZ (1) NZ573292A (enExample)
PL (1) PL2044025T3 (enExample)
PT (1) PT2044025E (enExample)
SI (1) SI2044025T1 (enExample)
WO (1) WO2008000839A1 (enExample)
ZA (1) ZA200809948B (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
EP2298900A1 (en) 1996-09-17 2011-03-23 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for treating intracellular diseases
ES2452965T3 (es) 2007-09-05 2014-04-03 Rigel Pharmaceuticals, Inc. Sal de xinafoato de N4-[(2,2-difluoro-4H-benzo[1,4]oxazin-3-ona)-6-il]-5-fluoro-N2-[3-(metilaminocarbonilmetilenoxi)fenil]-2,4-pirimidindiamina
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
WO2014141069A1 (en) 2013-03-14 2014-09-18 Novartis Ag Deamorphization of spray-dried formulations via spray-blending
ES2747905T3 (es) 2015-09-29 2020-03-12 Inke Sa Solvato mixto de L-tartrato de (R)-5-[2-(5,6-dietilindan-2-ilamino)-1-hidroxietil]-8-hidroxi-1H-quinolin-2-ona
CN110724095B (zh) * 2019-09-12 2023-06-09 上海方予健康医药科技有限公司 一种茚达特罗乙酸盐的制备方法
WO2026027448A1 (en) 2024-07-29 2026-02-05 Inke, S.A. Micronization process of indacaterol acetate

Citations (1)

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WO2002045703A2 (en) * 2000-12-04 2002-06-13 Novartis Ag Mixtures or organic compounds for the treatmentof airway diseases

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JPH05202301A (ja) * 1991-08-29 1993-08-10 Yamamoto Chem Inc ２−アニリノ−３−メチル−６−（Ｎ−ｎ−ブチル−Ｎ−シクロヘキシルアミノ）フルオランの結晶変態、その製造方法及びこの結晶変態を含有する記録材料
EP0688871A3 (en) * 1994-06-24 1998-07-08 Quest International B.V. Preparation of phytosphingosine derivative
FR2777279B1 (fr) * 1998-04-08 2004-08-13 Hoechst Marion Roussel Inc Nouvelles formes cristallines du 1s-[1alpha(2s*,3r*), 9 alpha] 6,10-dioxo-n-(2-ethoxy-5-oxo-tetrahydro-3-furanyl) -9[[(1-isoquinolyl)carbonyl]amino]octohydro-6h-pyridazino [1,2-a][1,2]diazepine-1-carboxamide
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
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TWI324150B (en) 2003-02-28 2010-05-01 Novartis Ag Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
TWI324151B (en) 2003-04-02 2010-05-01 Novartis Ag Process for the preparation of 5-(haloacetyl)-8-substituted oxy-(1h)-quinolin-2-ones
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JP2005343889A (ja) 2004-05-06 2005-12-15 Taisho Pharmaceut Co Ltd イミダゾピリジン誘導体
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Also Published As

Publication number Publication date
CY2020038I1 (el) 2021-03-12
CY2020038I2 (el) 2021-03-12
CY2020041I2 (el) 2021-03-12
SI2044025T1 (sl) 2013-01-31
PT2044025E (pt) 2012-12-17
MX2008016542A (es) 2009-01-19
LTPA2020535I1 (lt) 2020-12-28
ES2396987T3 (es) 2013-03-01
FIC20200050I1 (fi) 2020-12-16
FR20C1063I1 (fr) 2021-01-22
IL195796A (en) 2016-03-31
FR20C1054I1 (fr) 2020-12-25
US20090325912A1 (en) 2009-12-31
JP2009541455A (ja) 2009-11-26
PL2044025T3 (pl) 2013-02-28
AU2007264946A1 (en) 2008-01-03
CN101479245A (zh) 2009-07-08
CA2654801A1 (en) 2008-01-03
EP2044025A1 (en) 2009-04-08
NO2020044I1 (no) 2020-12-07
CA2654801C (en) 2014-08-19
MA30540B1 (fr) 2009-06-01
US8198450B2 (en) 2012-06-12
LUC00188I2 (enExample) 2024-07-01
LUC00185I2 (enExample) 2024-07-01
NZ573292A (en) 2011-03-31
IL195796A0 (en) 2009-09-01
HUS2000043I1 (hu) 2020-12-28
DK2044025T3 (da) 2013-01-14
JP5253392B2 (ja) 2013-07-31
ZA200809948B (en) 2009-05-25
BE2020C552I2 (enExample) 2026-07-08
HUS2000053I1 (hu) 2020-12-28
KR20090023651A (ko) 2009-03-05
BE2020C550I2 (enExample) 2026-07-08
AU2007264946B2 (en) 2011-01-20
WO2008000839A1 (en) 2008-01-03
EP2044025B1 (en) 2012-10-03
MY150468A (en) 2014-01-30
NO20090312L (no) 2009-01-28
NO341709B1 (no) 2018-01-02
US20120316142A1 (en) 2012-12-13
BRPI0713951A2 (pt) 2012-12-04
NO2020041I1 (no) 2020-11-23
BRPI0713951B8 (pt) 2021-05-25
FIC20200047I1 (fi) 2020-11-27
LTC2044025I2 (lt) 2022-10-10
CN101479245B (zh) 2013-05-22
CY1113733T1 (el) 2016-06-22
LTPA2020538I1 (lt) 2021-01-11
BRPI0713951B1 (pt) 2019-08-13
CY2020041I1 (el) 2021-03-12
HK1127597A1 (en) 2009-10-02
HRP20121074T1 (hr) 2013-01-31

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