KR101358574B1 - Xa 인자 억제제, n(5클로로2피리디닐)2[[4[(디메틸아미노)이미노메틸]벤조일]아미노]5메톡시벤자마이드의 약제학적 염 및 다형체 - Google Patents
Xa 인자 억제제, n(5클로로2피리디닐)2[[4[(디메틸아미노)이미노메틸]벤조일]아미노]5메톡시벤자마이드의 약제학적 염 및 다형체 Download PDFInfo
- Publication number
- KR101358574B1 KR101358574B1 KR1020087011799A KR20087011799A KR101358574B1 KR 101358574 B1 KR101358574 B1 KR 101358574B1 KR 1020087011799 A KR1020087011799 A KR 1020087011799A KR 20087011799 A KR20087011799 A KR 20087011799A KR 101358574 B1 KR101358574 B1 KR 101358574B1
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- salt
- compound
- salts
- acid
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73522405P | 2005-11-08 | 2005-11-08 | |
US60/735,224 | 2005-11-08 | ||
PCT/US2006/043635 WO2007056517A2 (en) | 2005-11-08 | 2006-11-07 | Pharmaceutical salts and polymorphs of n- (5-chl0r0-2-pyridinyl) -2- [ [4- [ (dimethylamino) iminomethyl] benzoyl] amino] -5-meth oxy-benzamide, a factor xa inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20080065662A KR20080065662A (ko) | 2008-07-14 |
KR101358574B1 true KR101358574B1 (ko) | 2014-02-04 |
Family
ID=38023988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020087011799A KR101358574B1 (ko) | 2005-11-08 | 2006-11-07 | Xa 인자 억제제, n(5클로로2피리디닐)2[[4[(디메틸아미노)이미노메틸]벤조일]아미노]5메톡시벤자마이드의 약제학적 염 및 다형체 |
Country Status (21)
Country | Link |
---|---|
US (7) | US7598276B2 (zh) |
EP (2) | EP2431358A1 (zh) |
JP (2) | JP5227178B2 (zh) |
KR (1) | KR101358574B1 (zh) |
CN (2) | CN102336702B (zh) |
AR (2) | AR056787A1 (zh) |
AT (1) | ATE549317T1 (zh) |
AU (1) | AU2006311544B2 (zh) |
BR (1) | BRPI0618362A2 (zh) |
CA (1) | CA2627086C (zh) |
DK (1) | DK1948608T3 (zh) |
ES (1) | ES2384116T3 (zh) |
HK (1) | HK1115131A1 (zh) |
IL (2) | IL190524A (zh) |
NZ (2) | NZ592533A (zh) |
PE (2) | PE20110070A1 (zh) |
PT (1) | PT1948608E (zh) |
RU (1) | RU2440986C2 (zh) |
TW (1) | TWI443088B (zh) |
WO (1) | WO2007056517A2 (zh) |
ZA (1) | ZA200803820B (zh) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
KR101195801B1 (ko) | 2004-06-18 | 2012-11-05 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Xa 인자 억제제 |
AU2006311544B2 (en) | 2005-11-08 | 2012-03-08 | Millennium Pharmaceuticals, Inc. | Pharmaceutical salts and polymorphs of N- (5-CHLORO-2-PYRIDINYL) -2- [ [4- [ (DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO] -5-METH OXY-BENZAMIDE, a factor XA inhibitor |
US20090186810A1 (en) * | 2006-03-27 | 2009-07-23 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
AR060768A1 (es) | 2006-05-05 | 2008-07-10 | Millennium Pharm Inc | Compuestos de imidazol sustituidos inhibidores del factor x, composiciones farmaceuticas que los contienen y usos como agentes antitromboticos. |
US8524907B2 (en) | 2006-11-02 | 2013-09-03 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor Xa inhibitor |
CA2913963A1 (en) * | 2006-12-08 | 2008-06-19 | Millenium Pharmaceuticals, Inc. | Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor |
WO2008086226A2 (en) * | 2007-01-05 | 2008-07-17 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
EP2155195B1 (en) | 2007-04-13 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor |
EP2146705B1 (en) * | 2007-05-02 | 2014-03-05 | Portola Pharmaceuticals, Inc. | Combination therapy with a compound acting as a platelet adp receptor inhibitor |
DK2915564T3 (da) | 2007-09-28 | 2021-02-08 | Alexion Pharma Inc | Antidoter mod faktor XA-inhibitorer og fremgangsmåder til anvendelse deraf |
PE20091156A1 (es) * | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
KR101649770B1 (ko) | 2008-11-14 | 2016-08-19 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 xa 저해제에 대한 해독제 및 혈액 응고제와 조합된 그의 사용 방법 |
EP3604510A1 (en) | 2009-03-30 | 2020-02-05 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
EP2453910B1 (en) | 2009-07-15 | 2016-08-31 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding |
JP5796872B2 (ja) * | 2009-12-17 | 2015-10-21 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 第Xa因子阻害剤の結晶性塩 |
PT2513058T (pt) * | 2009-12-17 | 2017-01-26 | Millennium Pharm Inc | Métodos de síntese de inibidores do fator xa |
US8742120B2 (en) * | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
EA015918B1 (ru) * | 2010-03-03 | 2011-12-30 | Дмитрий Геннадьевич ТОВБИН | УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa |
TW201221128A (en) | 2010-09-01 | 2012-06-01 | Portola Pharm Inc | Crystalline forms of a factor Xa inhibitor |
TW201240664A (en) | 2010-09-01 | 2012-10-16 | Portola Pharm Inc | Methods and formulations of treating thrombosis with betrixaban and a P-glycoprotein inhibitor |
CN102952138B (zh) * | 2011-08-17 | 2016-07-06 | 上海特化医药科技有限公司 | 一种吡唑并嘧啶酮化合物的盐、多晶型物及其药物组合物、制备方法和应用 |
WO2013033370A1 (en) * | 2011-08-31 | 2013-03-07 | Portola Pharmaceuticals, Inc. | Prevention and treatment of thrombosis in medically ill patients |
US9200268B2 (en) | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
CN104341343B (zh) * | 2013-07-24 | 2018-09-28 | 四川海思科制药有限公司 | 贝曲西班的晶型及其制备方法和用途 |
CN105085387A (zh) * | 2014-05-20 | 2015-11-25 | 四川海思科制药有限公司 | 贝曲西班盐及其制备方法和用途 |
KR102482517B1 (ko) | 2014-08-20 | 2022-12-28 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 xa 해독제용 동결건조된 제형 |
WO2017091757A1 (en) * | 2015-11-24 | 2017-06-01 | Portola Pharmaceuticals, Inc. | Isotopically enriched betrixaban |
CN106995405A (zh) * | 2016-01-25 | 2017-08-01 | 重庆医药工业研究院有限责任公司 | 一种贝曲西班马来酸盐无定型物及其制备方法 |
EP3419650B1 (en) | 2016-02-24 | 2021-06-02 | Alexion Pharmaceuticals, Inc. | Lyophilized formulations for factor xa antidote |
US20190300483A1 (en) * | 2016-06-02 | 2019-10-03 | Dr. Reddy's Laboratories Limited | POLYMORPHS OF BETRlXABAN & ITS MALEATE SALT |
EP3254674A1 (en) | 2016-06-08 | 2017-12-13 | Sandoz Ag | Pharmaceutical compositions of betrixaban maleate |
WO2017219034A2 (en) | 2016-06-17 | 2017-12-21 | Portola Pharmaceuticals, Inc. | Preparation of factor xa derivatives |
WO2018042320A1 (en) * | 2016-08-30 | 2018-03-08 | Dr. Reddy’S Laboratories Limited | Salts of betrixaban and processes for preparation thereof |
EP3293174A1 (en) | 2016-09-09 | 2018-03-14 | Sandoz Ag | Crystalline salts of betrixaban |
WO2018069936A1 (en) | 2016-10-13 | 2018-04-19 | Mylan Laboratories Limited | Polymorphs and solid dispersion of betrixaban and methods for the preparation thereof |
CN108017576B (zh) * | 2016-11-01 | 2022-06-21 | 石药集团中奇制药技术(石家庄)有限公司 | 一种贝曲西班及其盐酸盐的制备方法,以及它们的晶型 |
CN108586325A (zh) * | 2017-03-16 | 2018-09-28 | 上海度德医药科技有限公司 | 一种Betrixaban中间体的制备方法 |
WO2018229796A2 (en) | 2017-06-14 | 2018-12-20 | Mylan Laboratories Limited | A process for betrixaban hydrochloride and betrixaban maleate salt |
CN107868039A (zh) * | 2017-11-27 | 2018-04-03 | 中国药科大学 | 一种贝曲沙班中间体n-(5-氯-2-吡啶基)-2-[(4-氰基苯甲酰基)氨基]-5-甲氧基苯甲酰胺的制备方法 |
WO2022211680A1 (ru) * | 2021-03-30 | 2022-10-06 | Общество С Ограниченной Ответственностью "Фармадиол" | Способ получения антикоагулянта n-(5-хлорпиридин-2-ил)-2-({4-[этан-имидоил(метил)амино]бензоил}амино)-5-метилбензамид гидрохлорида |
CN115057854A (zh) * | 2022-04-19 | 2022-09-16 | 河北常山生化药业股份有限公司 | 马来酸阿伐曲泊帕中间体的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376515B2 (en) * | 2000-02-29 | 2002-04-23 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor Xa |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0675899B1 (en) | 1992-12-15 | 1999-03-17 | Corvas International, Inc. | NOVEL INHIBITORS OF FACTOR Xa |
GB9226238D0 (en) | 1992-12-16 | 1993-02-10 | Scherer Ltd R P | Encapsulation apparatus and process |
JP3004362B2 (ja) | 1994-12-02 | 2000-01-31 | 山之内製薬株式会社 | 新規なアミジノナフチル誘導体又はその塩 |
US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
ATE443698T1 (de) | 1996-12-23 | 2009-10-15 | Bristol Myers Squibb Pharma Co | Stickstoffhaltige heterocyclen als faktor xa- hemmer |
AU8747598A (en) | 1997-08-27 | 1999-03-16 | Kissei Pharmaceutical Co. Ltd. | 3-amidinoaniline derivatives, activated blood coagulation factor x inhibitors, and intermediates for producing both |
US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
US6844367B1 (en) * | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
KR100760434B1 (ko) | 1999-09-17 | 2007-10-04 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 벤즈아미드 및 관련된 Xa 인자의 억제제 |
US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
AU2006311544B2 (en) | 2005-11-08 | 2012-03-08 | Millennium Pharmaceuticals, Inc. | Pharmaceutical salts and polymorphs of N- (5-CHLORO-2-PYRIDINYL) -2- [ [4- [ (DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO] -5-METH OXY-BENZAMIDE, a factor XA inhibitor |
US8524907B2 (en) | 2006-11-02 | 2013-09-03 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor Xa inhibitor |
-
2006
- 2006-11-07 AU AU2006311544A patent/AU2006311544B2/en not_active Ceased
- 2006-11-07 EP EP11187927A patent/EP2431358A1/en not_active Withdrawn
- 2006-11-07 WO PCT/US2006/043635 patent/WO2007056517A2/en active Application Filing
- 2006-11-07 PE PE2010000471A patent/PE20110070A1/es not_active Application Discontinuation
- 2006-11-07 EP EP06837238A patent/EP1948608B1/en active Active
- 2006-11-07 US US11/594,280 patent/US7598276B2/en active Active
- 2006-11-07 BR BRPI0618362-0A patent/BRPI0618362A2/pt not_active Application Discontinuation
- 2006-11-07 RU RU2008123055/04A patent/RU2440986C2/ru not_active Application Discontinuation
- 2006-11-07 PE PE2006001368A patent/PE20070717A1/es active IP Right Grant
- 2006-11-07 AT AT06837238T patent/ATE549317T1/de active
- 2006-11-07 PT PT06837238T patent/PT1948608E/pt unknown
- 2006-11-07 CA CA2627086A patent/CA2627086C/en not_active Expired - Fee Related
- 2006-11-07 DK DK06837238.2T patent/DK1948608T3/da active
- 2006-11-07 ES ES06837238T patent/ES2384116T3/es active Active
- 2006-11-07 NZ NZ592533A patent/NZ592533A/xx not_active IP Right Cessation
- 2006-11-07 CN CN201110197429.0A patent/CN102336702B/zh active Active
- 2006-11-07 CN CN2006800415554A patent/CN101304971B/zh active Active
- 2006-11-07 JP JP2008540190A patent/JP5227178B2/ja not_active Expired - Fee Related
- 2006-11-07 KR KR1020087011799A patent/KR101358574B1/ko active IP Right Grant
- 2006-11-07 NZ NZ567992A patent/NZ567992A/en not_active IP Right Cessation
- 2006-11-08 AR ARP060104900A patent/AR056787A1/es not_active Application Discontinuation
- 2006-11-08 TW TW095141382A patent/TWI443088B/zh active
-
2008
- 2008-03-31 IL IL190524A patent/IL190524A/en active IP Right Grant
- 2008-05-05 ZA ZA200803820A patent/ZA200803820B/xx unknown
- 2008-09-23 HK HK08110550.3A patent/HK1115131A1/xx not_active IP Right Cessation
-
2009
- 2009-08-28 US US12/550,291 patent/US8557852B2/en not_active Expired - Fee Related
-
2011
- 2011-06-12 IL IL213487A patent/IL213487A0/en unknown
-
2012
- 2012-09-12 US US13/612,476 patent/US20130064806A1/en not_active Abandoned
- 2012-09-18 JP JP2012204757A patent/JP5662980B2/ja active Active
-
2014
- 2014-02-17 US US14/182,209 patent/US9061019B2/en not_active Expired - Fee Related
-
2015
- 2015-05-18 US US14/715,507 patent/US9555023B2/en active Active
-
2016
- 2016-12-12 AR ARP160103799A patent/AR106960A2/es unknown
- 2016-12-20 US US15/385,651 patent/US20170326119A1/en not_active Abandoned
-
2018
- 2018-03-08 US US15/915,940 patent/US20190046510A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376515B2 (en) * | 2000-02-29 | 2002-04-23 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor Xa |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101358574B1 (ko) | Xa 인자 억제제, n(5클로로2피리디닐)2[[4[(디메틸아미노)이미노메틸]벤조일]아미노]5메톡시벤자마이드의 약제학적 염 및 다형체 | |
US9221758B2 (en) | Methods of synthesizing pharmaceutical salts of a factor Xa inhibitor | |
JP2019135258A (ja) | 第Xa因子阻害剤の結晶形態 | |
KR20090107499A (ko) | 경구용 Xa 인자 억제제를 포함하는 단위 용량 제형 및 경구용 Xa 인자 억제제를 사용하는 혈전증의 치료 방법 | |
MX2008005143A (en) | Pharmaceutical salts and polymorphs of n- (5-chl0r0-2-pyridinyl) -2- [ [4- [ (dimethylamino) iminomethyl]benzoyl]amino]-5-meth oxy-benzamide, a factor xa inhibitor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20170120 Year of fee payment: 4 |
|
FPAY | Annual fee payment |
Payment date: 20180118 Year of fee payment: 5 |
|
FPAY | Annual fee payment |
Payment date: 20200116 Year of fee payment: 7 |