KR101329901B1 - 유사분열 키네신 억제제 및 이의 사용 방법 - Google Patents
유사분열 키네신 억제제 및 이의 사용 방법 Download PDFInfo
- Publication number
- KR101329901B1 KR101329901B1 KR1020077027972A KR20077027972A KR101329901B1 KR 101329901 B1 KR101329901 B1 KR 101329901B1 KR 1020077027972 A KR1020077027972 A KR 1020077027972A KR 20077027972 A KR20077027972 A KR 20077027972A KR 101329901 B1 KR101329901 B1 KR 101329901B1
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- difluorophenyl
- delete delete
- thiadiazol
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C1=N*=*=*1 Chemical compound C1=N*=*=*1 0.000 description 20
- VIEPLQJTFGGUOH-UHFFFAOYSA-N CC(C)c([s]c1c2)nc1ccc2-[n]1nc(C)nc1 Chemical compound CC(C)c([s]c1c2)nc1ccc2-[n]1nc(C)nc1 VIEPLQJTFGGUOH-UHFFFAOYSA-N 0.000 description 1
- FNADJUVIYGDFAJ-UHFFFAOYSA-N CC(C)c([s]c1c2)nc1ccc2C(N(C)C)=O Chemical compound CC(C)c([s]c1c2)nc1ccc2C(N(C)C)=O FNADJUVIYGDFAJ-UHFFFAOYSA-N 0.000 description 1
- WZWJYFALKYLZJV-UHFFFAOYSA-N CC(C)c([s]c1c2)nc1ccc2NC(N(C)C)=O Chemical compound CC(C)c([s]c1c2)nc1ccc2NC(N(C)C)=O WZWJYFALKYLZJV-UHFFFAOYSA-N 0.000 description 1
- IUQGYADCKOVDJZ-UHFFFAOYSA-N CC(C)c1nc2c(C)cccc2[s]1 Chemical compound CC(C)c1nc2c(C)cccc2[s]1 IUQGYADCKOVDJZ-UHFFFAOYSA-N 0.000 description 1
- LBGJEWZNHWTQQU-UHFFFAOYSA-N CC(C)c1nc2ccc(CNC(N(C)OC)=O)cc2[s]1 Chemical compound CC(C)c1nc2ccc(CNC(N(C)OC)=O)cc2[s]1 LBGJEWZNHWTQQU-UHFFFAOYSA-N 0.000 description 1
- VJUQCGLXCNHGEY-UHFFFAOYSA-N CCc1cccc2c1[s]c(C)n2 Chemical compound CCc1cccc2c1[s]c(C)n2 VJUQCGLXCNHGEY-UHFFFAOYSA-N 0.000 description 1
- KWUFEHJPAUGHGL-UHFFFAOYSA-N CNc1nc2ccc(CN(C)C)cc2[s]1 Chemical compound CNc1nc2ccc(CN(C)C)cc2[s]1 KWUFEHJPAUGHGL-UHFFFAOYSA-N 0.000 description 1
- BAMPVSWRQZNDQC-UHFFFAOYSA-N Cc1c(C)[s]c(C)n1 Chemical compound Cc1c(C)[s]c(C)n1 BAMPVSWRQZNDQC-UHFFFAOYSA-N 0.000 description 1
- SFZJHKKLNYFMJA-UHFFFAOYSA-N Cc1nc(C(N(C)C)=O)c[s]1 Chemical compound Cc1nc(C(N(C)C)=O)c[s]1 SFZJHKKLNYFMJA-UHFFFAOYSA-N 0.000 description 1
- KGBINGMJYXILDP-UHFFFAOYSA-N Cc1nc(CCNC2)c2[s]1 Chemical compound Cc1nc(CCNC2)c2[s]1 KGBINGMJYXILDP-UHFFFAOYSA-N 0.000 description 1
- XHANCLXYCNTZMM-UHFFFAOYSA-N Cc1nc(cc(C)cc2)c2[s]1 Chemical compound Cc1nc(cc(C)cc2)c2[s]1 XHANCLXYCNTZMM-UHFFFAOYSA-N 0.000 description 1
- JEKCSLMWKCKDCC-UHFFFAOYSA-N Cc1nc2ccc(C)cc2[s]1 Chemical compound Cc1nc2ccc(C)cc2[s]1 JEKCSLMWKCKDCC-UHFFFAOYSA-N 0.000 description 1
- JXQGICFGPUAVLJ-UHFFFAOYSA-N Cc1nnc(C)[s]1 Chemical compound Cc1nnc(C)[s]1 JXQGICFGPUAVLJ-UHFFFAOYSA-N 0.000 description 1
- GPNAVOJCQIEKQF-UHFFFAOYSA-N Nc([s]c1c2)nc1ccc2[N+]([O-])=O Chemical compound Nc([s]c1c2)nc1ccc2[N+]([O-])=O GPNAVOJCQIEKQF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/65392—Five-membered rings containing two nitrogen atoms
- C07F9/65395—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67689005P | 2005-05-02 | 2005-05-02 | |
| US60/676,890 | 2005-05-02 | ||
| PCT/US2006/016526 WO2006119146A1 (en) | 2005-05-02 | 2006-05-01 | Mitotic kinesin inhibitors and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20080003934A KR20080003934A (ko) | 2008-01-08 |
| KR101329901B1 true KR101329901B1 (ko) | 2013-11-14 |
Family
ID=37308299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077027972A Expired - Fee Related KR101329901B1 (ko) | 2005-05-02 | 2006-05-01 | 유사분열 키네신 억제제 및 이의 사용 방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7795282B2 (https=) |
| EP (1) | EP1879886B1 (https=) |
| JP (1) | JP2008540418A (https=) |
| KR (1) | KR101329901B1 (https=) |
| CN (1) | CN101248068A (https=) |
| AU (1) | AU2006242380A1 (https=) |
| BR (1) | BRPI0610193A2 (https=) |
| CA (1) | CA2606708C (https=) |
| IL (1) | IL186707A (https=) |
| MX (1) | MX2007013539A (https=) |
| NO (1) | NO20076186L (https=) |
| RU (1) | RU2007144612A (https=) |
| TW (1) | TW200716153A (https=) |
| UA (1) | UA95907C2 (https=) |
| WO (1) | WO2006119146A1 (https=) |
| ZA (1) | ZA200710218B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| UA95907C2 (en) | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| AR068888A1 (es) * | 2007-10-19 | 2009-12-16 | Schering Corp | Derivados de 1, 3, 4 - tiadiazol, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de la quinesina ksp. |
| US9561214B2 (en) * | 2008-10-16 | 2017-02-07 | Array Biopharma Inc. | Method of treatment using inhibitors of mitosis |
| DE102009058280A1 (de) | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | Thiazolderivate |
| EP2455456A1 (en) | 2010-11-22 | 2012-05-23 | Institut Curie | Use of kinesin inhibitors in HIV infection treatment and a method for screening them |
| WO2016094307A1 (en) | 2014-12-08 | 2016-06-16 | The Research Foundation For The State University Of New York | Anti-fungals targeting the synthesis of fungal shingolipids |
| WO2018232298A1 (en) | 2017-06-16 | 2018-12-20 | The Research Foundation For The State University Of New York | Anti-fungals compounds targeting the synthesis of fungal sphingolipids |
| MX2023001086A (es) * | 2020-08-07 | 2023-03-23 | Italfarmaco Spa | Nuevos inhibidores selectivos de histona desacetilasa 6 (hdac6) basados en oxadiazol. |
| CN114014824B (zh) * | 2020-12-09 | 2023-06-13 | 上海科技大学 | 一种杂环化合物的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003079973A2 (en) | 2002-03-08 | 2003-10-02 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| WO2005035512A1 (ja) | 2003-10-10 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | チアジアゾリン誘導体 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2702803A (en) * | 1954-04-12 | 1955-02-22 | Lilly Co Eli | Substituted heterodiazoles |
| ATE72431T1 (de) * | 1985-08-31 | 1992-02-15 | Fisons Plc | 5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren. |
| GB8625774D0 (en) * | 1986-10-28 | 1986-12-03 | Reckitt & Colmann Prod Ltd | Thiadiazole derivative |
| JPH0572686A (ja) | 1991-09-11 | 1993-03-26 | Konica Corp | ハロゲン化銀写真感光材料 |
| AU4288293A (en) * | 1992-04-27 | 1993-11-29 | E.I. Du Pont De Nemours And Company | Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines |
| US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
| US5972937A (en) * | 1995-02-02 | 1999-10-26 | Smithkline Beecham P.L.C. | Heterocyclic compounds possessing 5HT2C receptor antagonist activity |
| US5958957A (en) * | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| US5668159A (en) * | 1996-05-08 | 1997-09-16 | The Dupont Merck Pharmaceutical Company | 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists |
| AR011164A1 (es) | 1997-02-28 | 2000-08-02 | Lilly Co Eli | Compuestos heterociclicos, composiciones farmaceuticas que los comprenden, y metodos para inhibir la liberacion del peptido beta-amiloide y/o su sintesismediante el uso de dichos compuestos |
| SI1045839T1 (en) * | 1997-12-16 | 2004-06-30 | Warner-Lambert Company Llc | Novel amines as pharmaceutical agents |
| JP2000159756A (ja) | 1998-11-23 | 2000-06-13 | American Cyanamid Co | ２―アリ―ル―δ２―１，３，４―（オキサおよびチア）ジアゾリン殺虫および殺ダニ剤 |
| US6235762B1 (en) * | 1998-11-23 | 2001-05-22 | American Cyanamid Company | 2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents |
| US6380187B2 (en) * | 1999-03-25 | 2002-04-30 | Dingwei Tim Yu | Class of thiomorpholino substituted thiazoles |
| WO2001056994A1 (en) | 2000-02-04 | 2001-08-09 | Biogen, Inc. | Integrin antagonists |
| US6284480B1 (en) | 2000-04-03 | 2001-09-04 | Cytokinetics, Inc. | Antifungal assay |
| US20040248950A1 (en) * | 2001-08-24 | 2004-12-09 | Natsuki Ishizuka | Apo ai expression accelerating agent |
| DE10297353T5 (de) * | 2001-10-22 | 2005-01-27 | Outside In | Selbstausgebende Zigarettenpackung |
| ATE480527T1 (de) * | 2001-12-11 | 2010-09-15 | Kyowa Hakko Kirin Co Ltd | Thiadiazolinderivate zur krebsbehandlung |
| US20050004186A1 (en) * | 2002-12-20 | 2005-01-06 | Pfizer Inc | MEK inhibiting compounds |
| US20040167188A1 (en) * | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
| CA2517517C (en) | 2003-03-03 | 2012-12-18 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| CA2522594C (en) * | 2003-04-18 | 2012-01-24 | Kyowa Hakko Kogyo Co., Ltd. | Mitotic kinesin inhibitor |
| US7326790B2 (en) * | 2003-05-02 | 2008-02-05 | Rigel Pharmaceuticals, Inc. | Diphenylisoxazole compounds and hydro isomers thereof |
| WO2004099164A1 (en) * | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection |
| JP4847868B2 (ja) * | 2003-05-14 | 2011-12-28 | ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド | 化合物、及び、アミロイドベータの調節におけるその使用 |
| US20050075375A1 (en) * | 2003-05-14 | 2005-04-07 | Anadys Pharmaceuticals, Inc. | Heterocyclic compounds for treating hepatitis C virus |
| US20050009877A1 (en) * | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
| US7220745B2 (en) * | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
| JPWO2004111023A1 (ja) | 2003-06-10 | 2006-07-27 | 協和醗酵工業株式会社 | チアジアゾリン−１−オキシド誘導体 |
| US20070276017A1 (en) * | 2003-06-10 | 2007-11-29 | Chikara Murakata | Thiadiazoline Derivative |
| AU2004264533B2 (en) | 2003-08-15 | 2009-01-22 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| JP2005232016A (ja) | 2004-02-17 | 2005-09-02 | Kyowa Hakko Kogyo Co Ltd | オキサジアゾリン誘導体 |
| GB0406867D0 (en) | 2004-03-26 | 2004-04-28 | F2G Ltd | Antifungal agents |
| CA2576057A1 (en) * | 2004-08-18 | 2006-03-23 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| KR20070085949A (ko) * | 2004-11-10 | 2007-08-27 | 바스프 악티엔게젤샤프트 | 촉매의 재생 방법 |
| UA95907C2 (en) | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| EP2081918A2 (en) | 2006-10-03 | 2009-07-29 | Array Biopharma, Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| WO2008042982A2 (en) | 2006-10-03 | 2008-04-10 | Cola Jr Gary M | Microtreatment of iron-based alloy, apparatus and method therefor, and articles resulting therefrom |
-
2006
- 2006-01-05 UA UAA200713355A patent/UA95907C2/ru unknown
- 2006-05-01 BR BRPI0610193-3A patent/BRPI0610193A2/pt not_active IP Right Cessation
- 2006-05-01 KR KR1020077027972A patent/KR101329901B1/ko not_active Expired - Fee Related
- 2006-05-01 AU AU2006242380A patent/AU2006242380A1/en not_active Abandoned
- 2006-05-01 WO PCT/US2006/016526 patent/WO2006119146A1/en not_active Ceased
- 2006-05-01 EP EP06758821.0A patent/EP1879886B1/en not_active Expired - Lifetime
- 2006-05-01 RU RU2007144612/04A patent/RU2007144612A/ru not_active Application Discontinuation
- 2006-05-01 US US11/415,455 patent/US7795282B2/en not_active Expired - Fee Related
- 2006-05-01 MX MX2007013539A patent/MX2007013539A/es not_active Application Discontinuation
- 2006-05-01 CA CA2606708A patent/CA2606708C/en not_active Expired - Fee Related
- 2006-05-01 CN CNA2006800242288A patent/CN101248068A/zh active Pending
- 2006-05-01 JP JP2008510090A patent/JP2008540418A/ja active Pending
- 2006-05-02 TW TW095115570A patent/TW200716153A/zh unknown
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2007
- 2007-10-17 IL IL186707A patent/IL186707A/en active IP Right Grant
- 2007-11-27 ZA ZA200710218A patent/ZA200710218B/xx unknown
- 2007-11-30 NO NO20076186A patent/NO20076186L/no not_active Application Discontinuation
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2010
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2012
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2013
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2015
- 2015-03-19 US US14/663,286 patent/US9221841B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003079973A2 (en) | 2002-03-08 | 2003-10-02 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| WO2005035512A1 (ja) | 2003-10-10 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | チアジアゾリン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200716153A (en) | 2007-05-01 |
| US7795282B2 (en) | 2010-09-14 |
| AU2006242380A1 (en) | 2006-11-09 |
| WO2006119146A1 (en) | 2006-11-09 |
| US20130109656A1 (en) | 2013-05-02 |
| US20150191490A1 (en) | 2015-07-09 |
| EP1879886B1 (en) | 2014-07-09 |
| US20100331283A1 (en) | 2010-12-30 |
| CN101248068A (zh) | 2008-08-20 |
| US20140018399A1 (en) | 2014-01-16 |
| HK1115376A1 (en) | 2008-11-28 |
| BRPI0610193A2 (pt) | 2010-06-01 |
| US20060247178A1 (en) | 2006-11-02 |
| CA2606708A1 (en) | 2006-11-09 |
| EP1879886A4 (en) | 2010-09-08 |
| ZA200710218B (en) | 2009-07-29 |
| AU2006242380A2 (en) | 2008-07-03 |
| US8580828B2 (en) | 2013-11-12 |
| RU2007144612A (ru) | 2009-06-10 |
| NO20076186L (no) | 2008-02-01 |
| IL186707A0 (en) | 2008-02-09 |
| US8268871B2 (en) | 2012-09-18 |
| US9221841B2 (en) | 2015-12-29 |
| JP2008540418A (ja) | 2008-11-20 |
| MX2007013539A (es) | 2008-01-24 |
| UA95907C2 (en) | 2011-09-26 |
| IL186707A (en) | 2013-04-30 |
| CA2606708C (en) | 2015-01-06 |
| KR20080003934A (ko) | 2008-01-08 |
| EP1879886A1 (en) | 2008-01-23 |
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| Publication | Publication Date | Title |
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| US9221841B2 (en) | Mitotic kinesin inhibitors and methods of use thereof | |
| HK1115376B (en) | Inhibitors of mitotic kinesins and their therapeutical use | |
| AU2011213738B2 (en) | Mitotic kinesin inhibitors and methods of use thereof | |
| HK1106131B (en) | Mitotic kinesin inhibitors and methods of use thereof |
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