KR101315319B1 - Food composition for fatigue recovery containing extract of ginseng steamed red and Curcuma longa L. - Google Patents

Abstract

The present invention relates to a food composition containing red ginseng extract and turmeric extract at the same time and having an excellent effect on fatigue recovery by synergistic effects of red ginseng and turmeric. That is, the present invention relates to a food composition having an excellent effect of recovering mental fatigue (stress) and physical fatigue (exercise load) by a combination of red ginseng extract and turmeric extract.

Red ginseng, turmeric, curcumin, fatigue, stress

Description

Food composition for fatigue recovery containing extract of ginseng steamed red and Curcuma longa L.}

The present invention relates to a food composition having both red ginseng extract and turmeric extract at the same time and having an excellent effect on recovery of mental fatigue (stress) and physical fatigue (exercise load) by synergistic effects of red ginseng and turmeric.

In general, 'fatigue' refers to 'a condition in which work efficiency decreases when working', 'a state of confusion of constantness', or 'a state in which cerebral cortex restraint occurs'. Decrease ”.

When the signal of fatigue comes, the body needs time to take a break and recover. However, in a busy modern society, it is difficult to keep such a cycle of fatigue and recovery. Accumulation of fatigue due to overwork can lead to chronic fatigue and can lead to many diseases such as peptic ulcer, hypertension, and diabetes. Cancer, stroke, and heart disease are the three major causes of death in modern people, and overwork is the main cause of their deaths. Recently, the importance of exercise has been highlighted to enjoy the leisure of life due to the well-being craze, and to prevent and treat various adult diseases. This social interest is increasing the need for scientific food intake not only for athletes but also for the general public to improve athletic performance and to effectively recover from fatigue.

The expression of fatigue or stress builds up when the mind and body are not functioning well. In the case of 'fatigue', the state is not fully able to exert the force required for muscle contraction activity, i.e., the reduced performance of exercise (Gibson H, et al, Sports Med. 1985. 2 (2): 120-). 32) In contrast to physical fatigue, stress can be understood as an imbalance of physical rhythm that comes from mental overload. Therefore, fatigue in the broad sense is a concept that includes both fatigue and stress, and can be said to be a decrease in the ability to perform physical or mental activities. Specifically, fatigue is a state in which work efficiency is degraded mainly due to physical fatigue, and stress is mental. It refers to a state where confusion of homeostasis occurs due to fatigue (establishment of functional evaluation system related to fatigue recovery of KFDA's health functional food, research report).

Regarding fatigue recovery at home and abroad, most of the herbal medicines such as vitamin B group, red ginseng or ginseng, evening primrose oil, thorny oogapi, etc. are mixed. To try to include a comprehensive and somewhat abstract effect.

Ginseng (Panax ginseng CA Meyer) is a plant belonging to the genus Ogapi and ginseng. It has been used for more than 2,000 years in Korea, China, and Japan, and has been used for the purpose of preventing disease and extending the lifespan. Known efficacy and effects on the central nervous system, anticarcinogenic and anticancer activity, immune function control, antidiabetic, hepatic antifungal effect, cardiovascular disorders and anti-arteriosclerosis, blood pressure control, menopausal disorders improvement and osteoporosis Its effects on antistress and anti-fatigue, antioxidant activity and anti-aging effects are known (Latest Ginseng 'Components and Efficacy', Korea Ginseng and Tobacco Research Institute, 56-112, 1996). On the other hand, red ginseng is steamed and steamed raw ginseng (water ginseng) by steam or other methods, and after drying steamed ginseng, a browning reaction, that is, browning reaction, takes on pale yellow brown to red brown. Among various kinds of ginseng, red ginseng is known to show better efficacy than white ginseng. Lipid Peroxidation Inhibition and Antioxidant Activity Associated with Aging Inhibition (Matsunage, H. et al, Cancer Chemother Pharmacol. 33, 291-297. 1994., Kim, S. et al, J. Korean Agricultural Chemical Society.24. 161-166 1981.), and the effects on alcohol detoxification-related enzyme activity (Shin, M. Korean J. Ginseng Sci. 1. 59-78. 1976.), etc., have been reported to be more effective than white ginseng.

Curcuma longa L. is a perennial herb belonging to the family Ginger, which has been used for a long time in tropical South and Southeast Asia. Curcuma roots and stems play antioxidant and cytoprotective roles, the main constituents being known as curcumin and curcumin derivatives (Chatterjee, S. et al, Food Research International. 32.487-490. 1999. ). Curcumin has been shown to be effective in curcumin, which has antioxidant, anti-cancer, anti-inflammatory, antiviral, hypolipidemic and anti-inflammatory effects, and cholesterol reduction in the liver (An. B. et al, Korean J). Medicinal Crop Sci. 14 (3) 168-172. 2006).

Although there have been studies on the effect of cancer cell death (Volate, S. et al, Carcinogenesis. 26 (8): 1450-6. 2005) as an anticancer effect on the effects of red ginseng or ginseng and turmeric together, As a result, there is no practical use for the recovery of stress and exercise load.

Thus, the inventors of the present invention while researching to provide a composition having a complex effect to recover mental fatigue and physical fatigue, found that there is an excellent fatigue recovery effect when a combination of red ginseng extract and turmeric extract, To complete.

Therefore, it is an object of the present invention to provide a food composition that can effectively exhibit the fatigue recovery effect of mind and body by the complementary synergistic effect of red ginseng extract and turmeric extract.

In order to achieve the above object, the present invention provides a physical fatigue recovery food composition containing both red ginseng extract and turmeric extract as an active ingredient.

In addition, it provides a food composition for mental stress recovery containing red ginseng extract and turmeric extract at the same time as an active ingredient.

In the present invention, the red ginseng extract and turmeric extract is characterized in that it is mixed in a ratio of 5:37 ~ 100: 31.

Hereinafter, the present invention will be described in more detail.

The present invention provides a food composition for physical fatigue recovery containing both red ginseng extract and turmeric extract as an active ingredient, and a food composition for mental stress recovery containing both red ginseng extract and turmeric extract as an active ingredient.

In the present invention, the red ginseng extract and turmeric extract are preferably mixed at a ratio of 5:37 to 100: 31, and particularly preferably at a ratio of 75: 172. The food composition of the present invention is well formulated as a food in the above range, the composition prepared within the above range is suitable for ingestion as a food, and within the above range, the effects of each of red ginseng and turmeric are complementarily combined It is because it shows an excellent effect in the recovery of physical fatigue and mental stress.

In addition, in the present invention, the red ginseng extract and turmeric extract may be obtained by heating and extracting each of water or alcohol, followed by filtration and concentration under reduced pressure.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. However, these Examples and Experimental Examples are provided only for the purpose of illustration to help the understanding of the present invention, the scope and scope of the present invention is not limited by the following Examples and Experimental Examples.

Reference Example 1 Preparation of Red Ginseng Extract

Red ginseng 1kg about 10 times of water or alcohol was added and repeated extraction 2 ~ 3 times at 90 ~ 100 ℃ for 12 to 24 hours, filtered and concentrated under reduced pressure to obtain a red ginseng extract (ginseng saponin content 70 mg / g or more).

Reference Example 2 Preparation of Turmeric Extract

Water or spirit of about 10 times in 1kg of turmeric was added repeatedly for 2 to 3 times at 90-100 ° C. for 12 to 24 hours, filtered and concentrated under reduced pressure to obtain turmeric extract (curcumin content of 20 mg / g or more).

Reference Example 3 Preparation of Health Functional Food Composition

Red ginseng extract (liquid) and turmeric extract may be mixed in a ratio of 5:37 to 100: 31, preferably in a ratio of 75: 172 to prepare a health functional food composition for mental and physical fatigue recovery.

In addition, the health functional food composition is adjusted so that the combined amount of red ginseng extract and turmeric extract is contained in a dry weight of 10 ^-5 to 100% by weight relative to the total health functional food composition.

The composition of the present invention may suitably contain excipients, sugars, flavorings, pigments, fats and oils, proteins and the like as necessary in addition to the basic components.

The product form of the food composition for mental and physical fatigue recovery of the present invention is not particularly limited and is selected according to the use form, and examples thereof include powders, granules, capsules, pastes, and the like.

Example 1 Preparation of Health Functional Food Composition for Mental and Physical Fatigue Recovery

The red ginseng extract prepared in Reference Example 1 and the turmeric extract prepared in Reference Example 2 were uniformly mixed in a ratio of 75: 172 and used in the following fatigue recovery efficacy test.

Experimental Example 1 Efficacy Test on Mental Fatigue Recovery

1. Samples and Laboratory Animals

The composition prepared in Example 1, the red ginseng extract of Reference Example 1, the turmeric extract of Reference Example 2 were used, and the experimental animals were 5 week old Rat (Wistar) males and 6 week old mouse (Hairless) males.

In animal experiments, the control group was bred with AIN-93G as a basic diet, and the experimental group was bred with mixed AIN-93G with experimental samples (red ginseng, turmeric).

2. Experimental method

It consisted of a non-stress control group, a stress control group and a stress (experimental group 1, experimental group 2 and experimental group 3), each group was used 10 mice.

The experimental instrument was used as cage restraint cage (cage), and the experimental diet was a modified diet based on the composition of AIN-93G, and was fed for 4 weeks by the free feeding method.

The restraint stress was confined using a restraint cage for 3 hours before sacrifice, after breeding as an experimental diet, and a sample (serum or plasma, etc.) was collected after anesthesia.

As a biomarker for evaluating the fatigue recovery effect, cortisol, glucose, lactic acid, creatine phosphokinase, and the like were measured in the blood.

3. Results

<Comparison of Cortisol in Blood>

The amount of cortisol in the blood of the non-stress control group, the stress control group and the stress group (Experimental Group 1, Experimental Group 2 and Experimental Group 3) is shown in [Table 1].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Cortisol (㎍ / ㎗) 5.03 ± 1.32 38.33 ± 8.10 30.25 ± 6.82 32.41 ± 8.06 11.93 ± 2.04

Experimental group 1: red ginseng extract alone intake

Experimental group 2: ingestion of turmeric extract alone

Experimental group 3: red ginseng extract + turmeric extract complex intake

As shown in Table 1, the experimental groups 1, 2, and 3 decreased cortisol increase due to mental stress, and in particular, the experimental group 3, which was administered a combination of red ginseng extract and turmeric extract, was the most effective (p <0.05).

<Comparison of Creatine phosphokinase in the blood>

The amount of creatine phosphokinase in the blood of the non-stress control group, the stress control group and the stress group (Experimental Group 1, Experimental Group 2 and Experimental Group 3) is shown in [Table 2].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Creatine
Phosphokinase
(mU / ml) 41 ± 3.89 92.14 ± 8.80 80.04 ± 7.71 78.26 ± 9.42 62.05 ± 7.08

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in [Table 2], the experimental groups 1, 2, and 3 decreased the increase in creatine phosphokinase due to mental stress, especially the experimental group 3, which was administered a combination of red ginseng extract and turmeric extract, was the most effective (p <0.05). ).

<Comparison of the amount of glucose in the blood>

The amount of glucose in the blood of the non-stressed control group, the stress control group and the stress (experimental group 1, experimental group 2 and experimental group 3) is shown in [Table 3].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Glucose
(mg / dl) 98.52 ± 20.01 142.19 ± 21.17 132.12 ± 20.08 138.98 ± 28.85 117.48 ± 19.26

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in [Table 3], experimental groups 1, 2, and 3 were all restored to increase blood glucose due to mental stress, and the most effective group was experimental group 3, which was administered with red ginseng extract and turmeric extract (p <0.05).

<Comparison of Lactic Acid in Blood>

The amount of lactic acid in the blood of the non-stressed control group, the stress control group and the stress (experimental group 1, experimental group 2 and experimental group 3) are shown in [Table 4].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Lactic acid (mg / ㎗) 4.00 ± 1.10 39.92 ± 6.52 33.38 ± 10.11 34.45 ± 12.09 19.90 ± 6.68

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in [Table 4], the increase in lactic acid in the blood occurred due to mental stress, and it was confirmed that the recovery was most effective in the experimental group 3 (p <0.05).

Experimental Example 2 Efficacy Test on Physical Fatigue Recovery

1. Samples and Laboratory Animals

The composition prepared in Example 1, the red ginseng extract of Reference Example 1, the turmeric extract of Reference Example 2 were used, and the experimental animals were 5 week old Rat (Wistar) males and 6 week old mouse (Hairless) males.

In animal experiments, the control group was bred with AIN-93G as a basic diet, and the experimental group was bred with mixed AIN-93G with experimental samples (red ginseng, turmeric).

2. Experimental method

10 groups of mice were used. Each group was composed of a non-stress control group, a stress control group, and a stress group (experimental group 1, experimental group 2, and experimental group 3).

Experimental equipment was used for swimming (swimming) exercise load, and the experimental diet was modified diet based on the AIN-93G composition was bred for 4 weeks by free feeding method.

In the exercise load experiment, a weight of 5% of the weight was attached to the tail, and then obtained in a constant temperature bath, and the total swimming time was recorded immediately after the exhaustion determination (death). Immediately after exhaustion, a sample (serum or plasma, etc.) was taken at the cost of sacrifice.

To evaluate the fatigue recovery effect, exercise duration and biomarkers such as glucose, lactic acid, creatine phosphokinase, lactate dehydrogenase (LDH), etc. Measured.

3. Results

<Mouse Swimming Time Comparison>

The swimming time until the exhaustion of the mice of the non-stress control group, the stress control group and the stress (experimental group 1, experimental group 2 and experimental group 3) is shown in [Table 5].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Swimming time (minutes) - 29.20 ± 9.18 33 ± 11.11 31 ± 8.25 51 ± 14.29

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in [Table 5], the experimental groups 1, 2, and 3 increased the exercise time due to physical fatigue. 0.05).

<Comparison of the amount of glucose in the blood>

The amounts of glucose in the blood of the non-stressed control group, the stress control group and the stress (experimental group 1, experimental group 2 and experimental group 3) are shown in [Table 6].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Glucose
(mg / dl) 121 ± 10.52 79.99 ± 10.22 83.18 ± 8.99 83.45 ± 10.11 103.34 ± 11.08

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in [Table 6], all the experimental groups 1, 2, and 3 showed the result of the reduction of blood glucose caused by physical fatigue (exercise load), and the most effective in the experimental group 3, which was administered the red ginseng extract and the turmeric extract in combination. (P <0.05).

<Comparison of Lactic Acid in Blood>

The amount of lactic acid in the blood of the non-stressed control group, the stress control group and the stress (experimental group 1, experimental group 2 and experimental group 3) group is shown in [Table 7].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Lactic acid
(mmol / L) 1.08 ± 0.17 5.51 ± 1.15 4.89 ± 0.87 5.18 ± 1.20 2.93 ± 1.36

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in [Table 7], the increase in lactic acid caused by lack of oxygen supply in blood due to physical stress (exercise load) occurred, and it was confirmed that this was effectively recovered in Experiment 3 (p <0.05).

<Comparison of Creatine phosphokinase in the blood>

The amount of creatine phosphokinase in the blood of the non-stress control group, the stress control group and the stress group (Experimental Group 1, Experimental Group 2 and Experimental Group 3) is shown in [Table 8].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 Creatine
Phosphokinase
(mU / ml) 38 ± 2.99 108.14 ± 11.80 87.04 ± 6.71 88.26 ± 9.11 64.55 ± 7.24

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in [Table 8], the experimental groups 1, 2, and 3 decreased the increase in creatine phosphokinase due to physical stress (exercise load), and especially the experimental group 3, which was administered in combination with red ginseng extract and turmeric extract, was the most effective. (p <0.05).

<Comparison of Lactic Acid Dehydrogenase (LDH) in Blood>

The amount of lactic acid dehydrogenase (LDH) in the blood of the non-stress control group, the stress control group and the stress group (Experimental Group 1, Experimental Group 2 and Experimental Group 3) is shown in [Table 9].

Non-stress
Control group stress
Control group Experiment 1 Experiment 2 Experiment group 3 LDH (U / L) 127 ± 15.18 197.65 ± 16.28 172.25 ± 14.98 167.88 ± 15.11 142.86 ± 12.22

Experimental Group 1: Red Ginseng Extract Intake

Experimental group 2: ingestion of turmeric extract alone

Experimental Group 3: Red Ginseng Extract + Ulum Extract Complex Intake

As shown in Table 9, the activity of lactate dehydrogenase (LDH), which is an enzyme catalyzing the formation of lactic acid in the anaerobic state due to physical fatigue (exercise load), was recovered in experimental groups 1, 2, and 3. In particular, the recovery effect was the most excellent in the experimental group 3, which was administered a combination of red ginseng extract and turmeric extract (p <0.05).

As described above, the complex prescription composition of red ginseng and turmeric can reduce the increase of the stress hormone cortisol by mental stress, reduce the increase of serum creatine phosphokinase activity, and alleviate the increase of glucose in the blood, It can restore mental stress by restoring the increase in lactic acid. In addition, physical fatigue is improved by improving exercise persistence against physical fatigue (exercise load), relieving glucose reduction, restoring the increase of lactic acid, decreasing the increase of creatine phosphokinase activity, and restoring the increase of lactate dehydrogenase activity. It can have a restoring effect.

By the complex prescription of red ginseng and turmeric according to the present invention, it is possible to provide a food composition exhibiting an excellent effect on mental fatigue recovery and physical fatigue recovery.

Claims (6)

A physical fatigue recovery food composition containing red ginseng extract and turmeric extract as an active ingredient in a ratio of a weight ratio of 5:37 to 100: 31. delete The food composition according to claim 1, wherein the red ginseng extract and turmeric extract are obtained through a process of extracting from water or alcohol, and then filtering and concentrating under reduced pressure. A food composition for mental stress recovery comprising red ginseng extract and turmeric extract as an active ingredient in a ratio of 5:37 to 100: 31 by weight. delete The food composition according to claim 4, wherein the red ginseng extract and turmeric extract are obtained through a process of extracting from water or alcohol, and then filtration and concentration under reduced pressure.