KR20170122612A - Composition and its manufacturing method for sports nutrition comprising of Trigonella foenum-graecum extract and ferulic acid - Google Patents
Composition and its manufacturing method for sports nutrition comprising of Trigonella foenum-graecum extract and ferulic acid Download PDFInfo
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- KR20170122612A KR20170122612A KR1020160051821A KR20160051821A KR20170122612A KR 20170122612 A KR20170122612 A KR 20170122612A KR 1020160051821 A KR1020160051821 A KR 1020160051821A KR 20160051821 A KR20160051821 A KR 20160051821A KR 20170122612 A KR20170122612 A KR 20170122612A
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- ferulic acid
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/31—Foods, ingredients or supplements having a functional effect on health having an effect on comfort perception and well-being
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/33—High-energy foods and drinks, sports drinks
Abstract
Description
본 발명은 스포츠용 조성물 및 이의 제조방법에 관한 것으로, 본 발명에 따른 복합 조성물은 각각의 성분이 발휘하는 효과에 비하여 월등히 높은 운동수행능력의 향상과 더불어 빠른 피로회복을 도와주는 기능성 스포츠용 조성물 및 이의 제조방법에 관한 것이다.The present invention relates to a composition for sports and a method for producing the composition, and a composite composition for a functional sport for improving the exercise performance and a quick fatigue recovery, And a method for producing the same.
축구나 농구, 배구와 같은 구기 종목에서부터 육상, 체조 등을 비롯한 여러 경쟁적인 스포츠에서 경기력의 향상을 위해 수행되는 운동기능, 기술 그리고 트레이닝의 과학화는 결과적으로 운동수행력을 향상시키기 위해서 지속적이고 강도 높은 트레이닝과 적당량의 휴식이 요구되지만, 트레이닝적인 부분뿐만 아니라 다른 측면으로 트레이닝 전, 후의 충분한 영양 공급 역시 매우 중요한 부분으로 자리잡고 있다. 그러나 음식물을 통한 영양 공급에서의 한계와 보다 향상된 운동수행력 발휘를 위해서 또는, 운동 후의 빠른 피로회복이나 또는, 건강 증진에 도움을 얻고자 식이섭취 이외의 다양한 기능성 영양보충제들이 등장하게 되었으나, 이에 대한 명확한 검증이 불분명한 실정이다.Technological and technological developments in motor skills, techniques, and training that are performed to improve performance in various competitive sports such as soccer, basketball, and volleyball, as well as in athletics, gymnastics, and other competitive sports have resulted in continuous and intensive training And adequate amount of rest is required, but sufficient nutrition before and after training is also important as well as training part. However, a variety of functional nutritional supplements other than dietary supplements have emerged in order to limit the nutritional supply through food, to exercise more effectively, or to recover fast fatigue after exercise or to promote health. However, Verification is unclear.
운동수행능력의 향상은 훈련 강도와 양을 합리적으로 증가시키면서 운동부하에 대한 인체의 적응력을 길러나가는 과정의 반복이며 (이종각 외, 1994), 피로가 완전히 회복되지 않으면 운동능력이 저하될 뿐만 아니라, 근육통, 관절통, 건 염증과 더불어 불면증, 무력감 등의 부작용을 초래한다 (최석원, 1992). 따라서 운동 중이나 후에 누적된 피로를 얼마나 빨리 회복하는가 하는 것은 체력 향상의 핵심 요소가 된다. In addition, the exercise capacity is improved if the fatigue is not fully recovered (Lee, 1994). In addition, the exercise capacity is improved by increasing the strength and quantity of training rationally and increasing the adaptability of the human body to the exercise load. Muscle soreness, joint pain, dryness, insomnia, and helplessness (Choi, Suk Won, 1992). Therefore, how fast you recover accumulated fatigue during and after exercise becomes a key factor in improving your fitness.
피로는 높은 강도의 운동을 지속할 경우 신체에 지속적인 자극을 주어 수소이온(H+), 젖산탈수소효소(lactate dehydrogenase; LDH), 암모니아(ammonia), 젖산(lactic aicd), 무기인산(Pi) 등 에너지 대사 과정을 바탕으로 생리적인 여러 가지 대사 물질을 축적시켜서 야기된다. 이러한 피로는 정신적 혹은 신체적 작업이 연속적, 반복적으로 행해질 때 그것에 수반되어 발생하는 심신의 기능저하 상태(안영필 외, 1989), 신체적 활동을 수행하는데 있어 일시적으로 요구되는 힘을 발휘하는 능력을 손실하였을 때(Simon & Weiser, 1976; Asmussen, 1979), 주어진 운동강도나 요구되는 힘을 유지하지 못했을 때로 정의할 수 있다(Edward, 1983). 이러한 피로의 원인들을 제거해 주는 것을 피로회복이라고 말한다. 즉, 운동에 따른 대사 작용에 의해 축적된 부산물의 제거와 소모된 에너지원의 보충, 항상성의 회복, 중추신경피로의 회복 등을 피로회복이라고 하는 것이다(이종각 외, 1994) Fatigue is a process of sustaining high-intensity exercise that provides sustained stimulation to the body to produce energy such as hydrogen ion (H +), lactate dehydrogenase (LDH), ammonia, lactic aicd, It is caused by accumulating various physiological metabolites based on metabolism process. This fatigue is characterized by a state of mental and physical dysfunction accompanied by continuous and repetitive mental or physical work (Ahn, Pil, et al., 1989) and the loss of the ability to exert the temporary power required to perform physical activity (Simon & Weiser, 1976; Asmussen, 1979), and can be defined as failure to maintain a given strength or required force (Edward, 1983). Eliminating these causes of fatigue is called fatigue recovery. In other words, elimination of by-products accumulated by metabolism during exercise, supplementation of consumed energy sources, restoration of homeostasis, and restoration of central nervous fatigue are referred to as fatigue recovery (Lee, 1994)
특히, 운동 후에 회복기 과정에서 젖산을 비롯한 피로물질의 신속한 회복은 운동에 의한 체내 피로물질 축적으로 초래되는 운동수행능력 저하 방지는 물론 새로운 운동을 지속할 수 있다는 점에서 매우 중요하다. 과도한 운동으로 인한 대표적인 피로물질인 젖산의 빠른 제거가 곧 피로의 신속한 회복 및 운동수행능력을 증가시킬 수 있다(Bourdin et al., 2004; Hansen et al., 2005; Fate et al., 2002).In particular, rapid recovery of lactic acid and other fatigue substances during the recovery period after exercise is very important in that it can prevent the decrease in exercise performance caused by accumulation of fatigue substances in the body due to exercise and can continue the new exercise. The rapid removal of lactic acid, a representative fatigue substance due to excessive exercise, can increase the ability to rapidly recover from fatigue and exercise performance (Bourdin et al., 2004; Hansen et al., 2005; Fate et al., 2002).
이러한 운동수행능력을 증가시키는 방법에는 여러 가지가 있다. 그 중에서도 전문 운동선수나 프로스포츠 선수들을 포함하여 건강증진을 위해 운동을 하는 일반인들 중 운동에 특별한 관심을 가진 많은 이들은 운동수행능력을 증진시키거나 운동에서의 최대 효과를 얻기 위해 운동의 외적인 부분, 그 중에서도 특히 영양측면에서 많은 영양학적 보충제들을 사용하고 있다. 대표적인 예가 ergogenic aid, 즉 운동수행능력 향상용 보조제에 대한 많은 연구들이 수행되어 오고 있다. 그 중에서도 인삼이나 홍삼은 인체에 무해할 뿐만 아니라 그 효능이 월등하고 다원적인 측면으로 인하여 많은 주목을 받아 왔으며, 특히 신체 수행력 및 항 스트레스와 관련하여 스포츠 생리학, 영양학 그리고 의약학 분야에서 그 가능성이 지속적으로 타진되어 왔다(황인경, 1988).There are many ways to increase this exercise performance. In particular, many of the general public who exercise for health promotion, including professional athletes and professional athletes, have a special interest in exercising, in order to improve exercise performance or to obtain maximum effect from exercise, In particular, many nutritional supplements are used in terms of nutrition. A number of studies have been conducted on ergogenic aids, ie, supplements for improving exercise performance. Among them, ginseng and red ginseng are not only harmless to the human body, but also have been attracting much attention due to their superior efficacy and pluralism. Especially, in the field of sports physiology, nutrition and medicine, (Hwang In-kyung, 1988).
상기와 같이 인삼이나 홍삼 등의 식물 추출물을 함유하는 조성물에 대한 보고와 별도로 본 발명에서의 호로파 추출물과 페룰산을 동시에 함유하는 복합조성물은 상승 효과를 발휘하여 운동수행능력의 향상과 더불어 신속한 피로물질 제거효과를 발휘함을 확인함으로써 본 발명을 완성하였다.As described above, in addition to reports on compositions containing plant extracts such as ginseng and red ginseng, the composite composition containing both the fenugreek extract and ferulic acid in the present invention exhibits a synergistic effect, thereby improving the exercise performance, The present invention has been accomplished.
[선행기술문헌][Prior Art Literature]
-비특허문헌-- Non-Patent Document -
이종각 외, 운동피로원인과 회복 방법에 관한 문헌고찰, 체육과학논총, 6(4), 39-69 (1994)Lee, Jonggak et al., Literature Review on Causes and Recovery Methods of Exercise Fatigue, Journal of Physical Education Science, 6 (4), 39-69 (1994)
최석원, 스포츠 맛사지가 운동 후 회복기에 미치는 영향, 국민대학교 대학원 석사학위논문 (1992)Choi, Suk Won, Effects of Sports Massage on Recovery after Exercise, Master's Thesis, Graduate School, Kookmin University (1992)
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- 특허문헌-- Patent Literature -
특허공개 제10-2012-0107291호(호로파 추출물을 포함하는 뇌암 치료용 조성물 및 미백 기능성 화장품)Patent Publication No. 10-2012-0107291 (composition for treatment of brain cancer and extracts containing whitening functional cosmetic)
본 발명의 목적은 호로파 추출물 및 페룰산을 유효성분으로 함유하는 스포츠용 조성물을 제공하는 것으로서 본 발명의 조성물은 운동수행능력의 향상과 피로물질의 신속한 제거를 목적으로 한다.
An object of the present invention is to provide a sports composition containing a fenugreek extract and ferulic acid as an active ingredient. The composition of the present invention aims at improving exercise performance and rapidly removing fatigue substances.
본 발명은 호로파 추출물 및 페룰산을 유효성분으로 함유하는 스포츠용 조성물을 제공한다.The present invention provides a sports composition comprising a fenugreek extract and ferulic acid as an active ingredient.
본 명세서에서 사용된 용어, "호로파"는 콩과(Leguminosae)에 속하는 큰노랑꽃자리풀 Trigonella foenum-graecum L로서 씨, 열매, 잎을 식용으로 섭취하고 있으며, 온신양(溫腎陽) 거한습(祛寒濕)하는 효능을 지니고 있으므로 양위, 활설(滑泄), 산기(疝氣) 등에 활용되고 있다 (서부일, 호로파가 골다공증 흰쥐의 골밀도와 체중에 미치는 영향, 대한본초학회지 21(3), 97-102 (2006); 이철호 & 정지천, 호로파추출물의 Peroxynitrite 제거 및 염증인자 단백질 억제 효과, 대한한방내과학회지, 27(3), 688-697 (2006)).As used herein, the term " horopa "refers to Trigonella foenum-graecum L, a large yellow flora belonging to Leguminosae, which consumes seeds, fruits and leaves for edible purposes, (Oryza sativa L.), which has been shown to be effective in reducing osteoporosis and osteoporosis in osteoporotic rats, has been applied to menstruation, Lee, JH (Korea Food Research Institute, RDA, Suwon, Republic of Korea);
본 명세서에서 사용된 용어, “페룰산(Ferulic acid)"는 C10H10O4의 분자식을 가지는 신남산 유도체의 하나로 처음에는 Ferula foetida 식물로부터 분리하였으며 최근에는 주로 쌀의 미강으로부터 분리되는 것으로 알려져 있다. 페룰산은 항산화효과가 밝혀져 있으며 (Gupta S et al., Milchwissenschaf, 34, 205 (1979)), 피부미백효과 (Fragrance Journal, 45, 92 (1980)), 혈당 강하효과 (Nomura H et al., Research report of Wakayama industrial thechnology center, 17-9 (2001) 등이 알려져 있으며, 여러 나라에서 식품첨가물로 사용되고 있다.As used herein, the term " ferulic acid "is one of the derivatives of cinnamic acid having the molecular formula of C 10 H 10 O 4 , initially isolated from the ferula foetida plant, recently isolated from rice bran Ferulic acid has antioxidant effects (Gupta S et al., Milchwissenschaf, 34, 205 (1979)), skin whitening effect (Fragrance Journal, 45, 92 (1980)), hypoglycemic effect (Nomura H et al. , Research report of Wakayama industrial thechnology center, 17-9 (2001), and is used as a food additive in various countries.
본 발명의 목적을 달성하기 위하여, 상기 호로파 추출물은 호로파의 씨앗을 분쇄한 후 물이나 C1~C4 알코올, 또는 이들의 혼합용매로 추출하여 제조된 추출물인 것이 바람직하며,C1~C4 알코올로 추출한 추출물인 것이 더욱 바람직하나, 이에 한정하지 않는다.According to an aspect of the invention, the fenugreek extract is preferably prepared after grinding the seeds of fenugreek extracts with water or a C 1 ~ C 4 alcohols, or a mixed solvent extract and, C 1 ~ It is more preferable that the extract is extracted with C 4 alcohol, but it is not limited thereto.
상기 알코올은 메탄올 또는 에탄올인 것이 바람직하나, 이에 한정하지 않는다.The alcohol is preferably methanol or ethanol, but is not limited thereto.
본 발명의 일 실시예에서, 호로파 추출물은 호로파의 씨앗으로부터 30% 에탄올을 가하여 제조한 호로파 30% 에탄올 추출물을 이용하였다(실시예 1 참조). In one embodiment of the present invention, the fenugreek extract was a 30% ethanol extract of fenugreek prepared by adding 30% ethanol from fenugreek seeds (see Example 1).
따라서, 본 발명에 따른 호로파 추출물은 호로파 씨앗의 30% 에탄올 추출물인 것이 바람직하나, 이에 한정하지 않는다.Accordingly, the fenugreek extract according to the present invention is preferably a 30% ethanol extract of fenugreek seeds, but is not limited thereto.
또한 상기의 에탄올 추출물은 헥산 분획물, 에틸아세테이트 분획물, 부탄올 분획물, 물 분획물 또는 이들의 조합에 의한 분획물로도 제조할 수 있으며, 부탄올 분획물인 것이 더욱 바람직하고, 호로파 에탄올 추출물의 부탄올 분획물인 것이 가장 바람직하나, 이에 한정하지 않는다.The ethanol extract may be prepared by fractionation with hexane fraction, ethyl acetate fraction, butanol fraction, water fraction or a combination thereof, more preferably a butanol fraction, and the butanol fraction of the holofaethanol extract is most preferably But is not limited thereto.
본 발명의 목적을 달성하기 위하여, 상기의 페룰산은 일본의 Tsuno사에서 구입한 식품첨가물용 시료를 사용하였으나, 페룰산은 쌀의 미강으로부터 추출하기도 하고 또 화학합성법으로 제조한 것을 사용하기도 하므로 식품첨가물의 규격에 맞는 어느 원료를 사용하여도 무방할 것이다.In order to achieve the object of the present invention, the above-mentioned ferulic acid was used as a food additive sample purchased from Tsuno, Japan. However, since ferulic acid is extracted from rice bran and used by chemical synthesis, Any material that complies with the specification may be used.
본 발명에 따른 스포츠용 조성물은 호로파 추출물 및 페룰산 또는 하나 이상의 약학적으로 허용되는 담체, 부형제 또는 희석제를 추가로 포함할 수 있다.The sports composition according to the present invention may further comprise a fenugreek extract and ferulic acid or one or more pharmaceutically acceptable carriers, excipients or diluents.
본 발명의 약학적 조성물은 통상적인 방법에 따라 약학적 조성물 제형으로 제조될 수 있으며, 제형의 제조에 있어서, 활성 성분을 담체와 함께 혼합 또는 희석하거나, 용기 형태의 담체 내에 봉입시키는 것이 바람직하다. 담체가 희석제로 사용되는 경우에는 활성 성분에 대한 담체, 부형제 또는 매질로 작용하는 고형, 반고형 또는 액상의 물질일 수 있다. 따라서, 제형은 정제, 환제, 캡슐제, 과립제, 산제, 연고제, 액제, 드링크제 또는 주사제를 포함하여 샤세, 엘릭서, 현탁제, 유화제, 시럽제, 에어로졸제, 연질 또는 경질 캡슐제, 멸균주사제, 멸균분제 등 당 업계에서 공지되어 있는 다양한 형태의 조성물로 제형화할 수 있다. 또한, 본 발명의 조성물은 비경구 투여 형태인 크림제, 로션제, 연고제, 경고제, 액제, 에어로솔제, 유동엑스제, 엘릭서제, 침제 또는 패취제 등의 형태일 수 있다.The pharmaceutical composition of the present invention can be prepared into pharmaceutical composition formulations according to a conventional method. In the production of formulations, it is preferable that the active ingredient is mixed with or diluted with the carrier, or enclosed in a carrier in the form of a container. When the carrier is used as a diluent, it may be a solid, semi-solid or liquid substance acting as a carrier, excipient or medium for the active ingredient. Thus, the formulations may be in the form of tablets, capsules, granules, powders, ointments, liquids, solutions or injections, as well as powders, elixirs, suspensions, emulsions, syrups, aerosols, soft or hard capsules, sterile injections, May be formulated into various types of compositions known in the art. In addition, the composition of the present invention may be in the form of a parenteral dosage form such as a cream, a lotion, an ointment, an alarm, a liquid, an aerosol, a fluid extract, an elixir, an infiltrant or a patch.
적절한 담체, 부형제 및 희석제의 예로는, 락토오스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로오스, 메틸 셀룰로오스, 에틸 셀룰로오스, 하이드록시프로필 셀룰로오스, 미정질 셀룰로오스, 폴리비닐피롤리돈, 물, 메틸 하이드록시 벤조에이트, 프로필 하이드록시 벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유, 덱스트린, 칼슘 카보네이트, 프로필렌글리콜, 리퀴드 파라핀 및 생리식염수로 이루어진 군에서 선택된 1종 이상을 들 수 있으나, 이에 한정된 것은 아니며 통상의 담체, 부형제 또는 희석제 모두 사용이 가능하다. 또한, 본 발명의 조성물은 통상의 충진제, 증량제, 결합제, 붕해제, 항응집제, 윤활제, 습윤제, pH조절제, 영양제, 비타민, 전해질, 알긴산 및 그의 염, 펙트산 및 그의 염, 보호성 콜로라이드, 글리세린, 향료, 유화제 또는 방부제 등을 추가로 포함할 수 있다. 또한, 본 발명의 약학적 조성물은 상기 유효성분 이외에 운동수행능력의 향상 및 피로물질 제거용으로 사용되는 다른 물질을 하나 이상 포함할 수 있다.Examples of suitable carriers, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, ethylcellulose , Hydroxypropylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol, Saline, and the like. However, it is not limited to these, and any conventional carrier, excipient or diluent can be used. In addition, the composition of the present invention can be used as a filler, an extender, a binder, a disintegrant, an anticoagulant, a lubricant, a wetting agent, a pH adjuster, a nutrient, a vitamin, an electrolyte, an alginic acid and its salt, a pectic acid and its salt, Glycerin, fragrance, emulsifier or preservative, and the like. In addition, the pharmaceutical composition of the present invention may contain at least one substance other than the above-mentioned active ingredient, which is used for improving exercise performance and for removing fatigue substances.
본 발명의 약학적 조성물은 경구 또는 비경구 투여가 모두 가능하며, 일 예로는 경구, 경피, 피하, 정맥, 복강, 근육, 국소도포, 첩포 및 이온토포레시스 (iontoporesis)를 포함한 여러 경로를 통해 투여될 수 있고, 이 중에서 국소 적용 및 경구투여가 바람직하다. 또한, 본 발명의 조성물은 포유동물에 투여된 후 활성 성분의 신속, 지속 또는 지연된 방출을 제공할 수 있도록 당업계에 잘 알려진 방법을 사용하여 제형화할 수 있다.The pharmaceutical composition of the present invention can be administered orally or parenterally, and examples thereof include various routes including oral, transdermal, subcutaneous, intravenous, intraperitoneal, muscle, topical application, patch and iontoporesis The topical application and oral administration are preferred. In addition, the compositions of the present invention may be formulated using methods well known in the art to provide rapid, sustained or delayed release of the active ingredient after administration to the mammal.
본 발명에 따른 유효성분의 투여량은 체내에서 활성성분의 흡수도, 불활성화율 및 배설속도, 환자의 연령, 성별 및 상태, 치료할 질병의 중증 정도에 따라 적절히 선택되나, 경구 투여제의 경우 일반적으로 성인에게 1일에 본 발명의 호로파 추출물을 0.01g ~ 100g의 양으로 1회 내지 수회 나누어 투여할 수 있으며, 0.1g ~ 30g의 양으로 투여하는 것이 바람직하며, 또한 페룰산은 0.1mg ~ 1000mg의 양으로 1회 내지 수회 나누어 투여할 수 있으며, 5mg ~ 500mg의 양으로 투여하는 것이 바람직하다.The dosage of the active ingredient according to the present invention is appropriately selected depending on the degree of absorption, inactivation rate and excretion rate of the active ingredient in the body, the age, sex and condition of the patient, and severity of the disease to be treated. It is preferable to administer the herbal extract of the present invention to the adult in an amount of 0.01 g to 100 g per day or in several times, preferably in an amount of 0.1 g to 30 g per day, and the ferulic acid may be administered in an amount of 0.1 mg to 1000 mg It may be administered once to several times in an amount of from 5 mg to 500 mg.
본 발명의 일 실시예에서, 호로파 추출물은 호로파의 씨앗으로부터 70% 에탄올을 가하여 제조한 호로파 30% 에탄올 추출물을 이용하였다(실시예 1 참조). In one embodiment of the present invention, the fenugreek extract was a 30% ethanol extract of fenugreek prepared by adding 70% ethanol from fenugreek seeds (see Example 1).
따라서, 본 발명에 따른 호로파 추출물은 물 또는 에탄올 또는 물과 에탄올의 혼합 용매를 사용하여 추출한 것이 바람직하나, 이에 한정하지 않는다.Therefore, the fenugreek extract according to the present invention is preferably extracted using water or ethanol or a mixed solvent of water and ethanol, but is not limited thereto.
상기 호로파 추출물은 기능 성분의 농축을 통한 효과의 향상을 목적으로 2차적인 분획물을 제조하여 사용할 수 있으며, 이 경우 분획물은 헥산 분획물, 에틸아세테이트 분획물, 부탄올 분획물, 물 분획물 또는 이들의 조합에 의한 분획물인 것이 바람직하며, 호로파 추출물의 에틸아세테이트 분획물 또는 부탄올 분획물인 것이 더욱 바람직하나, 이에 한정하지 않는다.The fenugreek extract may be prepared by using a second fraction for the purpose of improving the effect of concentration of the functional ingredient. In this case, the fraction may be selected from the group consisting of hexane fraction, ethyl acetate fraction, butanol fraction, water fraction, It is more preferable that the fraction is the ethyl acetate fraction or the butanol fraction of the fenugreek extract, but the present invention is not limited thereto.
상기 스포츠용 조성물의 형태는 분말, 과립, 정제, 캡슐, 시럽제 또는 음료인 것이 바람직하나, 이에 한정하지 않는다.The form of the sports composition is preferably a powder, a granule, a tablet, a capsule, a syrup or a beverage, but is not limited thereto.
본 발명의 스포츠용 조성물은 호로파 추출물 및 페룰산을 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용될 수도 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다.The sports composition of the present invention may be used as it is, or may be used in combination with other food or food ingredients, and may be suitably used according to a conventional method.
상기 조성물의 종류에는 특별한 제한은 없다. 상기 조성물의 예로는 육류, 소시지, 빵, 초콜릿, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알코올음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강식품을 모두 포함한다.The kind of the composition is not particularly limited. Examples of the composition include dairy products such as meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen noodle, other noodles, gums and ice cream, various soups, drinks, tea, drinks, And includes all health foods in a conventional sense.
본 발명의 실시예에 기재한 스포츠용 음료 조성물은 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상술한 천연 탄수화물은 포도당, 과당과 같은 모노사카라이드, 말토스, 슈크로스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나, 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100 ㎖당 일반적으로 약 0.01 ~0.04 g, 바람직하게는 약 0.02 ~ 0.03 g 이다.The beverage composition for sports described in the examples of the present invention may contain various flavors or natural carbohydrates as an additional ingredient like ordinary beverages. Such natural carbohydrates are monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, and polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. Examples of sweeteners include natural sweeteners such as tau martin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like. The ratio of the natural carbohydrate is generally about 0.01 to 0.04 g, preferably about 0.02 to 0.03 g per 100 ml of the composition of the present invention.
상기 외에 본 발명의 호로파 추출물 및 페룰산 복합 스포츠용 조성물은 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다.In addition to the above, the composition of fenugreek extract and ferulic acid complex for sports according to the present invention may further comprise various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloid thickeners, Stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like.
그 밖에 본 발명의 스포츠용 조성물은 비타민류나 아미노산류, 천연 과일주스, 과일 주스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 혼합하여 사용할 수 있다. 이러한 첨가제의 비율은 크게 중요하진 않지만 본 발명의 조성물 100 중량부 당 0.01~10.0 중량부의 범위에서 선택되는 것이 일반적이다.In addition, the sports composition of the present invention may contain flesh for the production of vitamins, amino acids, natural fruit juices, fruit juice drinks and vegetable drinks. These components may be used independently or in combination. The proportion of such additives is not critical, but is generally selected in the range of 0.01 to 10.0 parts by weight per 100 parts by weight of the composition of the present invention.
통상적으로 스포츠용 조성물 섭취를 통해 운동능력을 개선하기 위해서는 운동 지구력을 향상하거나 피로물질 감소를 촉진시켜야 한다. In general, in order to improve athletic ability through ingestion of sports composition, it is necessary to improve exercise endurance or to reduce fatigue substance.
본 발명에 따른 호로파 추출물 및 페룰산 복합 조성물은 운동지구력의 현저한 향상과 더불어 혈중 젖산 농도를 신속하게 감소시킴이 확인되었다.It was confirmed that the fenugreek extract and ferulic acid complex composition according to the present invention rapidly improve the endurance of exercise and the blood lactate concentration rapidly.
본 발명의 일 실시예에서, 호로파 추출물 및 페룰산 복합 조성물에 대하여 실험동물에 투여하여 운동지구력과 피로물질 감소 효과를 확인하는 실험을 한 결과, 호로파 추출물 단독 투여군, 페룰산 단독 투여군 및 대조군에 비하여 수영 지구력과 Tread mill 지구력을 현저하게 향상시키는 효과를 나타냈으며, 또한 피로물질인 젖산의 혈중 농도를 신속하게 감소시키는 것을 확인하여 본 발명을 완성하였다.In one embodiment of the present invention, an experiment was conducted to examine the effect of the fenugreek extract and ferulic acid complex composition on the endurance and fatigue reduction effects of experimental animals. As a result, the fenugreek extract alone, ferulic acid alone, , The swelling endurance and the Tread mill endurance were remarkably improved and the blood concentration of lactic acid, which is a fatigue substance, was rapidly reduced, thereby completing the present invention.
따라서, 본 발명의 호로파 추출물 및 페룰산 복합 조성물은 전혀 독성이 없어 안전성이 우수할 뿐만 아니라 부작용의 염려가 없으며, 또한 효과적으로 운동 수행 능력을 향상시키고 피로물질을 신속하게 감소시키는 효과를 발휘하므로 스포츠용 조성물로 유용하게 사용이 가능하다.
Accordingly, the fenugreek extract and ferulic acid composite composition of the present invention are not toxic at all and thus have excellent safety, have no adverse effects, exhibit an effect of effectively improving exercise performance and rapidly reducing fatigue substances, And can be usefully used as a composition.
본 발명의 호로파 추출물 및 페룰산 복합 조성물은 운동 지구력의 현저한 향상과 더불어 혈액 중에서 피로물질을 신속히 감소시킴으로써 운동수행능력을 효과적으로 개선하므로 스포츠용 조성물로서 유용하게 사용될 수 있다.The fenugreek extract and ferulic acid complex composition of the present invention can remarkably improve the endurance of exercise and rapidly reduce the fatigue substance in the blood, effectively improving the exercise performance, and thus can be usefully used as a composition for sports.
또한, 본 발명의 호로파 추출물은 전통적으로 식용으로 사용되는 안전한 원료이며, 페룰산도 이미 여러 나라들에서 식품첨가물 원료로 오래 동안 사용되고 있으므로 독성의 염려가 없는 안전한 스포츠용 조성물로서 유용하게 사용될 수 있다.
In addition, the fenugreek extract of the present invention is a safe raw material traditionally used for food, and since ferulic acid has already been used as a food additive ingredient in various countries for a long time, it can be effectively used as a safe sports composition without toxicity.
이하 본 발명을 하기 실시예에서 보다 상세하게 기술한다. 다만, 하기 실시예는 본 발명의 내용을 예시하는 것일 뿐 본 발명의 권리범위를 제한하거나 한정하는 것이 아니다. 본 발명의 상세한 설명 및 실시예로부터 본 발명이 속하는 기술분야의 통상의 기술자가 용이하게 유추할 수 있는 것은 본 발명의 권리범위에 속하는 것으로 해석된다.
Hereinafter, the present invention will be described in more detail in the following Examples. It should be noted, however, that the following examples are illustrative only and do not limit or limit the scope of the present invention. It will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
본 실시예의 운동수행능력과 피로회복을 향상시키는 스포츠용 조성물을 제조하는 방법은,The method of manufacturing a sports composition for improving exercise performance and fatigue recovery according to the present embodiment,
(a) 호로파를 건조한 후 분쇄하는 단계;(a) drying and crushing the mortar;
(b) 상기 호로파를 물 또는 에탄올, 물과 에탄올 혼합용매로 추출하여 추출액을 습득하는 단계;(b) extracting the eluate with water or a mixed solvent of ethanol and water and ethanol to obtain an extract;
(c) 상기 추출액을 농축하여 호로파 추출물을 수득하는 단계(c) concentrating the extract to obtain a fenugreek extract
(d) 상기 호로파 추출물에 페룰산을 첨가하여 조성물을 제조하는 단계를 포함한다.(d) adding ferulic acid to the fenugreek extract to prepare a composition.
구체적인 실시예는 아래와 같다.
Specific examples are as follows.
<실시예 1> 호로파 추출물의 제조≪ Example 1 > Preparation of fenugreek extract
호로파 (씨앗) 1Kg을 취하여 분쇄기를 사용하여 분쇄한 후 70% 식용주정 5L를 가하여 50℃로 가온하면서 10시간 동안 1차 추출하였다. 추출액을 여과한 후 잔류물에 신선한 70% 식용주정 5L를 가하여 50℃에서 10시간 동안 2차 추출하였다. 2차 추출액을 여과한 후 1차 추출액과 합하여 회전감압농축기에서 완전히 농축하여 호로파 추출물 약 100g을 수득하였다.
1 Kg of fenugreek (seed) was pulverized using a pulverizer, and then 5 L of a 70% food extract was added and the mixture was first extracted for 10 hours while being heated to 50 캜. After filtering the extract, 5 L of a fresh 70% edible alcohol was added to the residue, followed by secondary extraction at 50 ° C for 10 hours. The second extract solution was filtered, and the filtrate was combined with the first extract solution and completely concentrated in a rotary evaporator to obtain about 100 g of fenugreek extract.
<실시예 2> 페룰산 복합 조성물의 제조Example 2 Preparation of Ferulic Acid Composite Composition
페룰산 (Ferulic acid)는 일본 Tsuno Co. Ltd.사로부터 구입한 식품첨가물 원료를 사용하였다. 상기에서 제조한 호로파 추출물과 페룰산을 다음과 같은 조성으로 아래의 제조방법을 거쳐서 스포츠용 조성물을 제조하였다.
Ferulic acid was purchased from Tsuno Co., Japan. Ltd. were used. The above-prepared fenugreek extract and ferulic acid were prepared in the following composition through the following production process.
본 발명의 호로파 추출물 및 페룰산의 복합 스포츠용 조성물을 제조하기 위하여 정제수 100 중량부에 대하여 먼저 증점제인 메틸셀룰로오스(methylcellulose) 0.1 중량부를 가하여 교반하면서 완전히 용해시킨 다음 상기에서 제조한 호로파 추출물 1.0 중량부와 페룰산 0.1 중량부를 가하여 완전히 용해시켜서 동물실험용 조성물을 제조하였다. In order to prepare a composite composition for a fenugreek extract of ferulic acid and ferulic acid according to the present invention, 0.1 part by weight of methylcellulose, which is a thickening agent, was added to 100 parts by weight of purified water and completely dissolved with stirring. And 0.1 part by weight of ferric acid were added and completely dissolved to prepare an animal test composition.
비교 실험을 위하여 호로파 추출물 단독 투여군은 상기의 조성물에서 페룰산을 제외하고 제조한 조성물이며, 페룰산 단독 투여군은 상기의 조성물에서 호로파 추출물을 제외하고 제조한 조성물이다.
For comparative experiments, the group administered alone with fenugreek extract was a composition prepared by excluding the ferulic acid from the above composition, and the fenugic acid alone administration group was a composition prepared by excluding the fenugreek extract from the above composition.
<실시예 3> ICR 마우스를 이용한 수영 운동 지구력 향상 효과<Example 3> Improvement of swimming endurance using ICR mouse
상기 실시예 2에서 제조한 호로파 추출물 및 페룰산 복합 조성물이 운동능력 향상 효과를 나타내는지를 확인하기 위하여 하기와 같이 실험을 실시하였다.The following experiment was carried out to confirm whether the fenugreek extract and ferulic acid composite composition produced in Example 2 exhibited an athletic performance improving effect.
상기에서 제조한 각 조성물을 ICR 마우스에 2주간 매일 1회씩 경구로 투여한 후 swimming pool에서 마우스의 수영 능력을 측정함으로써 스포츠용 조성물의 운동수행능력 (motor activity) 및 혈중 젖산농도에 미치는 영향을 측정하였다. Vehicle(0.1% 메틸셀룰로오스 용액)만 투여한 대조군, 호로파 추출물 단독 투여군, 페룰산 단독 투여군 및 호로파 추출물과 페룰산의 복합 스포츠용 조성물 투여군의 4군으로 나누어 각 군당 7마리씩의 마우스를 배정하여 실험하였다.Each of the compositions prepared above was orally administered to ICR mice once a day for 2 weeks and then the swimming ability of the mice was measured in a swimming pool to measure the effect on the motor activity and blood lactate concentration of the sports composition Respectively. The mice were divided into four groups: vehicle (0.1% methylcellulose solution) alone, control group with holofa extract alone, ferulic acid alone group, and compound sports composition with fenugreek extract and ferulic acid. Seven mice were assigned to each group Respectively.
먼저 투명한 swimming pool (240W X 390L X 175Hmm)에 수돗물을 받아 물의 높이가 13cm가 되도록 한 다음 얼음 또는 온수를 이용하여 물의 온도를 25℃로 맞추고 최종적으로 수면의 높이를 13cm로 정하여 실험하였다.First, tap water was taken in a transparent swimming pool (240W X 390L X 175Hmm) to make the height of the water 13cm, and then the temperature of the water was adjusted to 25 ° C using ice or hot water. Finally, the height of the water surface was set to 13cm.
체중 25±2g의 ICR 마우스를 투여 종료일 오전에 계면활성제(애경산업)가 포함된 swimming pool(0.2%)에서 1분간 수영시키고, 즉시 수돗물만 있는 swimming pool로 옮겨 다시 1분간 수영시켜 마우스의 체모에 묻어 있는 지방을 제거하고, 지방 제거 후 약 3시간 동안 마우스를 관찰통에 넣어 체모를 건조시키고 체력을 회복시켰다.ICR mice weighing 25 ± 2 g were swam for 1 minute in a swimming pool (0.2%) containing surfactant (Aekyung Industry) on the end of the day of administration, immediately transferred to a swimming pool containing only tap water, The fat was removed, and the fat was removed and the mouse was placed in the observation tube for about 3 hours to dry the hairs and regain their physical strength.
시험물질 및 대조물질 (vehicle) 투여 1시간 후에 계면활성제가 포함된 swimming pool(0.01%)에 마우스를 넣고 수영시간을 측정한다. 수영의 종료 시점은 마우스가 swimming pool의 바닥에 3초 이상 가라앉았을 때를 기준으로 한다. 대조군에 대한 시험물질 투여군의 수영시간의 증가 혹은 감소 정도를 측정하였다.One hour after administration of the test substance and the vehicle, the mouse is put into the swimming pool (0.01%) containing the surfactant and the swimming time is measured. The end point of the swim is based on when the mouse has been submerged on the bottom of the swimming pool for more than 3 seconds. The increase or decrease in the swimming time of the test substance-administered group to the control group was measured.
2주간 상기 실시예 2에서 제조한 호로파 추출물 및 페룰산의 복합 스포츠용 조성물을 경구투여한 실험군과 호로파 추출물 단독 투여군, 페룰산 단독 투여군 및 Vehicle만을 투여한 대조군 (투여 용량 각각 50ml/Kg체중)의 지구력 및 피로도 실험을 행하기 위하여 각 군의 마우스에 체중의 4~8%의 무게를 꼬리에 부착하여 실시하였다.The control group (oral administration dose: 50 ml / Kg body weight, 50 mg / kg body weight) was divided into two groups: oral administration group of felopyridol and ferulic acid prepared in Example 2, fullofurate alone group, ferulic acid alone group and vehicle alone ) Were subjected to endurance and fatigue experiments by attaching 4 ~ 8% of body weight to the tail of mice in each group.
근육의 지구력을 평가하기 위하여 각 시험물질 투여군과 대조군 마우스의 수조 내 수영시간을 측정한 후 30분간 휴식을 취하게 한 다음 채혈하여 젖산의 농도를 측정하였다. 혈액 1ml를 취하여 1000rpm에서 20분간 원심분리 하여 혈청을 분리한 다음 Sigma사의 분석 Kit를 이용하여 측정하였으며, lactate reagent 1ml에 혈청 또는 젖산 표준용액을 0.01ml를 넣고 반응시킨 후 10분 이내에 540nm에서 흡광도를 측정하였다.In order to evaluate the endurance of muscles, the swimming time of each test substance-treated group and the control mice in the water bath was measured, and after resting for 30 minutes, the concentration of lactic acid was measured by collecting blood. 1 ml of blood was centrifuged at 1000 rpm for 20 minutes, and the serum was separated and analyzed using Sigma's analytical kit. After 0.01 ml of serum or lactate standard solution was added to 1 ml of lactate reagent, the absorbance was measured at 540 nm within 10 min. Respectively.
[그림 1] 마우스를 이용한 강제수영시험으로 운동지구력 측정결과[Figure 1] Results of exercise endurance test by forced swimming test using mouse
(Cont: 대조군, HO: 호로파 추출물, FA:페룰산, HO+FA: 호로파추출물 +페룰산 복합 조성물)(Cont: control group, HO: fenugreek extract, FA: ferulic acid, HO + FA: fenugreek extract + ferulic acid complex composition)
[그림 2] 마우스를 이용한 강제수영시험 후 혈중 젖산 농도 측정 결과[Figure 2] Results of blood lactate concentration measurement after forced swimming test using mouse
(Cont: 대조군, HO: 호로파 추출물, FA:페룰산, HO+FA: 호로파추출물 +페룰산 복합 조성물)(Cont: control group, HO: fenugreek extract, FA: ferulic acid, HO + FA: fenugreek extract + ferulic acid complex composition)
<실시예 4> SD랫드를 이용한 Tread mill 운동 지구력 측정<Example 4> Tread mill exercise endurance measurement using SD rats
6주령의 수컷 SD 랫드 (Speague-Dowley rat)를 1주일간 예비사육한 후 7마리씩 무작위로 4그룹으로 나누었다. 즉 대조군, 호로파 추출물 단독 투여군, 페룰산 단독 투여군 및 호로파 추출물과 페룰산 복합 조성물 투여군의 4군으로 나누고, 각 군의 실험동물에 상기에서 제조한 각 조성물을 50ml/Kg체중의 용량으로 매일 1회씩 4주간 경구로 투여하였다. Six-week-old male SD rats (Speague-Dowley rats) were pre-fed for one week and then randomly divided into 4 groups of 7 rats. In other words, the control was divided into four groups: a group administered alone, a group administered with fenugreek extract, a group administered with ferulic acid alone, and a group administered with fenugreek and a mixture of fenugreek and ferulic acid. Each of the compositions prepared above was administered to each animal in a dose of 50 ml / Once a day for 4 weeks.
1주차에는 15m/min의 속도로 10°의 경사를 10분 동안 주당 3회 운동시켰으며, 2주차에는 20m/min의 속도로 12°의 경사를 15분 동안 주당 3회 운동시켰으며, 3주차에는 25m/min의 속도로 14°의 경사를 20분 동안 주당 3회 운동시켰으며, 4주차에는 첫날에 탈진 시까지 Tread mill에서 운동을 시키고, Ether 마취 후 안와정맥총을 이용하여 채혈하여 피로 바이오마커인 젖산 농도를 분석하였다. At week 1, a 10 ° slope at 15 m / min was exercised three times a week for 10 minutes. At week 2, a 12 ° slope at 20 m / min was exercised three times a week for 15 minutes, The animals were anesthetized with a tread mill until the first day of discharge, and were anesthetized with an orbital venom and blood samples were collected for fatigue biomarkers The concentration of phosphorus acid was analyzed.
4주차 첫날에 탈진 시까지의 총 운동시간을 측정하여 표4에 나타내었다. 탈진에 대한 최종 판정은 Tread mill의 기저부에서 머무는 동안 3번의 전기자극에도 반응하지 않을 시 탈진한 것으로 간주하였다. 아래 표4에서 보듯이 본 발명의 호로파 추출물과 페룰산의 복합 조성물 투여군은 각각의 단독 투여군에 비하여 탈진시까지 운동시간이 월등히 증가한 것을 알 수 있다.
On the first day of the 4th week, the total exercise time until the discharge was measured, and it is shown in Table 4. The final judgment for draining was considered draining if it did not respond to three electrical stimuli during stay at the base of the tread mill. As shown in Table 4 below, it can be seen that the exercise time was significantly increased until the burnout compared with the single administration group of the combination composition of the fenugreek extract and ferulic acid.
[그림 3] 랫드를 이용한 Treadmill test로 운동지구력 향상 효과 측정한 결과 (Cont: 대조군, HO: 호로파 추출물, FA:페룰산, HO+FA: 호로파추출물 +페룰산 복합 조성물)The results of measuring exercise endurance improvement effect by treadmill test using rats (Cont: control group, HO: fenugreek extract, FA: ferulic acid, HO + FA: fenugreek extract + ferulic acid combination composition)
탈진 후 안와정맥총에서 채혈한 후 분리된 혈청 중 피로물질인 젖산의 농도를 측정하여 아래 표5에 나타내었다. Table 5 shows the concentration of lactic acid, which is the fatigue substance in the separated serum after blood sampling from the orbital vein.
고강도 운동 시 산소 공급량이 근육의 산소 소모량에 미치지 못하는 경우 근육 조직의 젖산 농도가 증가하게 되고, 이 때 생성된 젖산은 혈액으로 확산되어 심장 및 간에서 처리되게 된다. If the oxygen supply during the high intensity exercise is less than the oxygen consumption of the muscle, the lactic acid concentration in the muscle tissue is increased, and the lactic acid produced is diffused into the blood and treated in the heart and liver.
4주간 시험물질 투여가 끝난 후 탈진 시까지 고강도 운동으로 대조군의 젖산의 농도는 증가하였으며, 시험물질인 호로파 추출물 단독 투여군 및 페룰산 단독 추출물 투여군의 젖산 농도 감소 효과에 비하여 호로파 추출물과 페룰산의 복합 조성물은 훨씬 젖산 농도 감소 효과가 크게 나타나는 것을 확인할 수 있었다.The concentration of lactic acid in the control group was increased by high intensity exercise after the end of 4 weeks of test substance administration and compared to the effect of lactose concentration reduction in the test group alone or in the ferulic acid alone extract group, The effect of decreasing the concentration of lactic acid was significantly increased.
[그림 4] 랫드를 이용한 Treadmill test 후 혈중 젖산 농도 측정 결과(Cont: 대조군, HO: 호로파 추출물, FA:페룰산, HO+FA: 호로파추출물 +페룰산 복합 조성물)Results of measurement of blood lactate concentration after treadmill test using rats (Cont: control group, HO: fenugreek extract, FA: ferulic acid, HO + FA: fenugreek extract + ferulic acid combination composition)
상기의 실험결과들로부터, 본 발명의 호로파 추출물 및 페룰산 복합 조성물은 ICR 마우스의 수영 운동 지구력의 현저한 향상과 SD랫드의 Tread mill 운동 능력의 현저한 향상과 더불어 혈중 피로물질인 젖산의 신속한 감소 효과를 나타냄이 확인되었으며, 이러한 호로파 추출물 및 페룰산 복합 조성물의 효과는 호로파 추출물의 단독 투여군 또는 페룰산의 단독 투여군에 비하여 2배 정도의 개선효과를 가지는 것으로 2가지 성분의 복합 조성물을 통하여 운동수행 능력의 현저한 개선 효과를 발휘하였으므로 스포츠용 조성물로서 유용하게 사용될 수 있을 것으로 기대된다.
From the above experimental results, it can be seen that the fenugreek extract and ferulic acid composite composition of the present invention significantly improve the swimming endurance of the ICR mouse and the remarkable improvement of the tread mill exercise ability of the SD rats and the rapid decrease of the lactic acid, The ferulic acid and ferulic acid composition of the present invention have a two-fold improvement in the effect of the ferulic acid extract alone or ferulic acid alone, It is expected that it can be usefully used as a composition for sports.
이상에서 본 발명의 실시예에 대해서 상세히 설명하였으나, 이는 하나의 실시예에 불과하며, 이로써 본 발명의 특허청구범위를 한정하는 것은 아니다. 본 실시예를 바탕으로 균등한 범위까지 당업자가 변형 및 추가하는 범위도 본 발명의 권리범위에 속한다 할 것이다.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. Modifications and additions by those skilled in the art to an equivalent range based on the embodiments will also fall within the scope of the present invention.
Claims (2)
A composition for improving exercise performance and fatigue recovery, comprising a fenugreek extract and ferulic acid.
(b) 상기 호로파를 물 또는 에탄올, 물과 에탄올 혼합용매로 추출하여 추출액을 습득하는 단계;
(c) 상기 추출액을 농축하여 호로파 추출물을 수득하는 단계
(d) 상기 호로파 추출물에 페룰산을 첨가하는 단계를 포함하는 운동수행능력과 피로회복을 향상시키는 스포츠용 조성물 제조방법(a) drying and crushing the mortar;
(b) extracting the eluate with water or a mixed solvent of ethanol and water and ethanol to obtain an extract;
(c) concentrating the extract to obtain a fenugreek extract
(d) adding a ferulic acid to the fenugreek extract to produce a sports composition capable of improving exercise performance and fatigue recovery
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