KR101291960B1 - 장내세균에 의한 생물학적 활성제의 제어된 생산 및 전달 - Google Patents

장내세균에 의한 생물학적 활성제의 제어된 생산 및 전달 Download PDF

Info

Publication number
KR101291960B1
KR101291960B1 KR1020077019503A KR20077019503A KR101291960B1 KR 101291960 B1 KR101291960 B1 KR 101291960B1 KR 1020077019503 A KR1020077019503 A KR 1020077019503A KR 20077019503 A KR20077019503 A KR 20077019503A KR 101291960 B1 KR101291960 B1 KR 101291960B1
Authority
KR
South Korea
Prior art keywords
biologically active
delete delete
ovatus
mull2
bacterium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020077019503A
Other languages
English (en)
Korean (ko)
Other versions
KR20070108882A (ko
Inventor
시몬 카딩
마크 패라
Original Assignee
플랜트 바이오사이언스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 플랜트 바이오사이언스 리미티드 filed Critical 플랜트 바이오사이언스 리미티드
Publication of KR20070108882A publication Critical patent/KR20070108882A/ko
Application granted granted Critical
Publication of KR101291960B1 publication Critical patent/KR101291960B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077019503A 2005-01-25 2006-01-24 장내세균에 의한 생물학적 활성제의 제어된 생산 및 전달 Expired - Fee Related KR101291960B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0501540.9 2005-01-25
GBGB0501540.9A GB0501540D0 (en) 2005-01-25 2005-01-25 Controlled production and delivery of biologically active agents by gut bacteria
PCT/GB2006/000222 WO2006079790A2 (en) 2005-01-25 2006-01-24 Controlled production and delivery of biologically active agents by gut bacteria

Publications (2)

Publication Number Publication Date
KR20070108882A KR20070108882A (ko) 2007-11-13
KR101291960B1 true KR101291960B1 (ko) 2013-08-09

Family

ID=34259652

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077019503A Expired - Fee Related KR101291960B1 (ko) 2005-01-25 2006-01-24 장내세균에 의한 생물학적 활성제의 제어된 생산 및 전달

Country Status (10)

Country Link
US (1) US7988961B2 (enExample)
EP (1) EP1841875B1 (enExample)
JP (1) JP4989490B2 (enExample)
KR (1) KR101291960B1 (enExample)
AT (1) ATE483811T1 (enExample)
CA (1) CA2640343C (enExample)
DE (1) DE602006017331D1 (enExample)
ES (1) ES2353721T3 (enExample)
GB (1) GB0501540D0 (enExample)
WO (1) WO2006079790A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9371510B2 (en) * 2007-10-26 2016-06-21 Brenda E. Moore Probiotic compositions and methods for inducing and supporting weight loss
EP2258844A1 (en) 2009-05-28 2010-12-08 Helmholtz Zentrum Für Infektionsforschung Tumour-specific bacterial promoter elements
CN102462837B (zh) * 2010-11-19 2016-08-03 生物林格斯Ip有限公司 抗炎组合物
WO2015095796A1 (en) 2013-12-20 2015-06-25 President And Fellows Of Harvard College An engineered genetic enteric sensor bacteria and uses thereof
US9688967B2 (en) 2014-12-05 2017-06-27 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
US20160206666A1 (en) 2014-12-22 2016-07-21 Synlogic, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
CA2971876A1 (en) * 2014-12-22 2016-06-30 Massachusetts Institute Of Technology Probiotic organisms for diagnosis, monitoring, and treatment of inflammatory bowel disease
RU2017130462A (ru) * 2015-03-02 2019-04-02 Синлоджик, Инк. Бактерия, созданная для лечения заболеваний, облегчаемых при уменьшении воспаления кишечника и/или укреплении мукозного барьера кишечника
ES2881384T3 (es) 2015-05-13 2021-11-29 Synlogic Operating Co Inc Bacterias manipuladas para reducir la hiperfenilalaninemia
US11685925B2 (en) 2015-10-30 2023-06-27 Synlogic Operating Company, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
US11618894B2 (en) 2015-11-16 2023-04-04 Synlogic Operating Company, Inc. Bacteria engineered to reduce hyperphenylalaninemia
AU2017252409B2 (en) * 2016-04-20 2023-08-24 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for nucleic acid expression and protein secretion in bacteroides
EP3554518A4 (en) 2016-12-15 2020-07-29 The Board of Trustees of the Leland Stanford Junior University COMPOSITIONS AND METHODS FOR MODULATING THE GROWTH OF A GENETICALLY MODIFIED INTESTINAL BACTERIAL CELL
KR20190122710A (ko) * 2017-02-14 2019-10-30 캘리포니아 인스티튜트 오브 테크놀로지 행동 및 질환에서의 4-에틸페놀 및 4-에틸페놀 술페이트의 미생물적 합성의 조정
US20200268813A1 (en) * 2017-02-15 2020-08-27 President And Fellows Of Harvard College Modulation of host immune cell populations using gut microbiota
US11384358B2 (en) 2017-03-29 2022-07-12 President And Fellows Of Harvard College Method of regulating gene expression in a cell
CN113454229A (zh) 2018-12-10 2021-09-28 诺沃梅生物技术股份有限公司 用于治疗高草酸尿症的方法和组合物
CN115298308A (zh) 2020-03-20 2022-11-04 同生运营公司 经工程化以减轻高苯丙氨酸血症的微生物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965641A2 (en) * 1992-04-07 1999-12-22 Société des Produits Nestlé S.A. Integrative gene-expression in food-grade microorganisms

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60033823T2 (de) * 1999-09-10 2007-12-06 The Secretary Of State For Defence, Salisbury Rekombinante mikroorganismen
JP2001275680A (ja) * 2000-03-31 2001-10-09 Yakult Honsha Co Ltd β−１，３−キシラナーゼ遺伝子、該遺伝子を導入した微生物、及びβ−１，３−キシラナーゼの製造法
JP2003144200A (ja) * 2001-11-07 2003-05-20 Yakult Honsha Co Ltd バクテロイデスグループ細菌用プローブおよびこれを用いた検出方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965641A2 (en) * 1992-04-07 1999-12-22 Société des Produits Nestlé S.A. Integrative gene-expression in food-grade microorganisms

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FEMS MICROBIOLOGY LETTERS, Vol. 66, no. 1-3, pp.61-66, 1990. *
Nature Biotechnology, Vol. 21, no. 7, pp.785-789, 2003. *
Science, Vol. 289, no. 5483, pp.1352-1355, 2000. *

Also Published As

Publication number Publication date
EP1841875A2 (en) 2007-10-10
KR20070108882A (ko) 2007-11-13
JP4989490B2 (ja) 2012-08-01
GB0501540D0 (en) 2005-03-02
US20080131402A1 (en) 2008-06-05
EP1841875B1 (en) 2010-10-06
CA2640343C (en) 2014-01-14
US7988961B2 (en) 2011-08-02
WO2006079790A2 (en) 2006-08-03
CA2640343A1 (en) 2006-08-03
WO2006079790A3 (en) 2006-12-21
JP2008527988A (ja) 2008-07-31
DE602006017331D1 (de) 2010-11-18
ES2353721T3 (es) 2011-03-04
ATE483811T1 (de) 2010-10-15

Similar Documents

Publication Publication Date Title
KR101291960B1 (ko) 장내세균에 의한 생물학적 활성제의 제어된 생산 및 전달
KR102469701B1 (ko) 점막부착성 미생물
KR101557509B1 (ko) 락토코커스 프로모터 및 그것의 용도
CN1195860C (zh) 生物学活性多肽的输送
CA2738781C (en) Reduced colonization of microbes at the mucosa
RU2653757C2 (ru) Модифицированные грамположительные бактерии и их применение
JP5085547B2 (ja) 生理活性ポリペプチドの細菌性送達
KR20140027405A (ko) 박테리아용 폴리시스트론 발현 시스템
US20120144509A1 (en) Novel strains of helicobacter pylori and uses thereof
Farrar et al. Engineering of the gut commensal bacterium Bacteroides ovatus to produce and secrete biologically active murine interleukin‐2 in response to xylan
Campos et al. Lactococcus lactis as an interleukin delivery system for prophylaxis and treatment of inflammatory and autoimmune diseases
JP2019526262A5 (enExample)
JP2024544610A (ja) 遺伝的に改変された微生物及びその使用
JP6117212B2 (ja) 改変されたグラム陽性菌及びその使用
Rottiers et al. Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis
CN101052705A (zh) 自身遏制性乳杆菌菌株
CN110172433A (zh) 一种产猪表皮生长因子的重组枯草芽孢杆菌工程菌及应用
Steidler In Situ Delivery of Cytokines at Mucosal Surfaces by Genetically Engineered
HK1227928A1 (en) Lactococcus promoters and uses thereof

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

J201 Request for trial against refusal decision
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PJ0201 Trial against decision of rejection

St.27 status event code: A-3-3-V10-V11-apl-PJ0201

PB0901 Examination by re-examination before a trial

St.27 status event code: A-6-3-E10-E12-rex-PB0901

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

St.27 status event code: A-3-4-F10-F13-rex-PB0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20160726

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20160726