KR101202178B1 - Pharmaceutical composition containing leaves and fruits of phellodendron amurense - Google Patents

Abstract

The present invention relates to a pharmaceutical composition containing the leaves or fruits of the yellow wall, and the pharmaceutical composition containing the fruits or leaves of the yellow wall trees according to the present invention has an alleviating effect on atopic dermatitis, dandruff, scalpitis or blotch. It can be usefully used as various formulations in the art.

Description

PHARMACEUTICAL COMPOSITION CONTAINING LEAVES AND FRUITS OF PHELLODENDRON AMURENSE}

The present invention relates to a pharmaceutical composition containing the leaves or fruits of yellow wall, and more particularly, to a pharmaceutical composition for alleviating atopic dermatitis, dandruff, scalp salt or blotch using yellow leaves or fruits.

In modern society, atopic dermatitis, dandruff, scalp infection, skin diseases such as blotch, hair loss and nerve hypersensitivity are becoming more serious due to side effects and genetic factors such as stress, environmental pollution, drug addiction and misuse, etc. However, the medical knowledge and physiological action of this has not made much progress yet.

Atopy (atopy) means "weird" or "inappropriate", and the cause of atopic dermatitis has not yet been clearly identified, so the symptoms are also expressed in various ways, such as dry skin, eczema. Atopic dermatitis, also known as fever, is accompanied by chronic diseases of the skin, as well as allergic diseases such as hay fever. This condition is called allergic eczema, pediatric eczema, ectopic eczema, pancreatic neurodermatitis, etc. and is a clinical category of clinical and histological processes that show progression from infant eczema to typical thyroid dermatitis in boys, puberty, and adults. . Atopic dermatitis is a chronic relapsing eczema disease, the cause and pathogenesis of which are not clear. It is now understood that atopic dermatitis is mainly caused by a unique genetic predisposition, but its cause is not simple and is caused by a multi-factorial. Several external environmental factors that are involved in exacerbation of atopic dermatitis are well known, and the genetic predispositions present in patients with atopic dermatitis and their families, as well as their clinical and immunological forms, are currently weak.

On the other hand, the scalp is generally replaced with a new scalp at a faster rate than the hair, which is replaced with new cells about once a month. In a healthy scalp, the stratum corneum cells fall off to an invisible size and quickly replace with new keratinocytes. However, too many keratinocytes are produced and clumps of keratinocytes are visible and peeled off the scalp. This is called dandruff. Therefore, dandruff is not a hair surface problem, but a scalp problem and not a health problem.

Black mushrooms are round or oval brown or black spots or raised forms that occur in the sun-exposed area, and appear frequently in the UV-exposed areas such as the face, back, back of the hand, arms and legs, but may also occur in other areas. However, since the causal relationship between external stimuli (UV, ROS, etc.) and blotch development is unclear in the process of blotch development of the skin, an effective method of controlling blotch development has not been developed. In addition, attempts to understand the properties of various proteins in order to understand the characteristics of blotch are also limited to studies in culture systems in which cells (eg, kojic acid, hydroquinone, etc.) or stimulants (UV, ROS) are treated in cells. It has its limitations.

There are two types of androgenetic alopecia, which are male hormone-dependent chronic type alopecia and hair loss caused by seborrheic dermatitis. The former is directly related to the amount of testosterone, and the latter is a sebum-related disorder. Testosterone, one of the male hormones, is tested by 5 alpha-reductase, and another male hormone, dihydr, It is converted to testosterone (dihydrotestosterone (DHT)) and develops due to excess sebum production due to abnormal excess of this hormone. Conventionally, antibacterial agents or exfoliants such as alpha hydroxy acid (AHA) and vitamin A have been used for the treatment of seborrheic dermatitis, but only a very limited amount is used due to the slight irritation or excessive skin irritation. It is used. Antimicrobials that are commonly used include antibiotics such as retracycline, and these antibiotics are known to have a high possibility of causing side effects such as bactericidal bleeding or photosensitivity.

In addition, studies have been reported to inhibit the activity of 5-alpha-reductase that causes hair loss by converting testosterone to dihydrotestosterone (Yasuro sugimoto et al., Cation inhibit specifically type I 5α-reductase found in human skin, J. Invest. Dermatol., 104, 1995), its effect and effectiveness are known to be small and considerable care is required.

On the other hand, the neurological nature of neurosensitivity depends on both heredity and the environment, and, like other personalities, depends on the genes and the individual's developmental state. If you are easily sentimental or emotionally weak, you increase your risk of depression.

Yellow wall (Phellodendron amurense RUPR.) Is native to Korea, Japan, China, etc., and is the same plant as Phellodendron amurense var. SCHMIDT), P. molle NAKAI, P. sachalinense SAKGENT, and P. insulare NAKAI. Huangpisu (P.chinensis) is found in Yunnan and Hubei, China, and P. sacharinensis is produced in Sichuan, China, and P.wilsoni is in Taiwan. . The bark of the yellow-walled tree and the same root plant is called Phellodendri Cortex, which contains about 1.5 to 4.5% of yellow or yellow-brown pigment and several alkaloids. . The main component of alkaloids is berberine. Guanidine, jatrorrizine, magnoflorine, magnoflorine, phellod endrine, candicine, palmatine, menisperine (menisperine, n-methylisocorydinum) It contains alkaloids such as obacuunone, obaculactone, dictamnolide, obacuunonic acid, lumicaerulei acid, 7-dihydro It is known to contain stigmasterol (7-dehydrostigmasterol), β-sitosterol (camphorol) and the like. These ingredients have strong antibacterial action, blood pressure lowering action, central nerve suppression action, acetylcholine enhancement action and anti-inflammatory action and have been used for bone disease and jaundice in herbal or medicinal wood. It is also effective for typhoid fever, cholera, stomach, and formal wear, and its bark has been used for gastroenteritis, abdominal pain, jaundice as a high-density agent, formal medicine, and anti-inflammatory astringent drugs pp790-791 (1998).

Korean Patent Application No. 2000-008670 discloses a functional food material for the prevention and improvement of dementia using complex herbal extracts including yellow wall, but the muscarine M1 receptor binding inhibition activity of the yellow wall extract. Is only mentioned.

Accordingly, the present inventors completed the present invention by discovering that the fruits and leaves of the yellow-yellow tree have an effect on alleviation of atopic dermatitis, dandruff, scalpitis, or blotch while researching the efficacy of the yellow wall tree for a long time.

An object of the present invention is to provide a pharmaceutical composition containing the fruit and leaves of the yellow wall.

In order to achieve the above object, the present invention provides a cream-like composition having atopic dermatitis mitigation effect prepared by fermenting for 5 months by mixing 5 to 20% by weight of yellow bark fruit and 80 to 95% by weight fruit liquor shochu. .

The present invention also provides a cream-like composition having a dandruff or scalp salt relieving effect, comprising 10 to 20% by weight of yellow bark fruit and 80 to 90% by weight of water.

The present invention also provides a cream-like composition having a mildew mushroom relaxation effect prepared by mixing 20 to 40% by weight of the yellow wall leaves and 60 to 80% by weight of water and heating at 100 to 150 ° C.

The pharmaceutical composition containing the fruit or leaves of the yellow bark prepared according to the present invention has a relieving effect on atopic dermatitis, dandruff, scalpitis or blotch and can be usefully used in various formulations in the art.

The technical terms and scientific terms used in the present invention can be construed as meaning ordinary meanings understood by those of ordinary skill in the art without departing from the scope of the present invention.

The present invention provides a pharmaceutical composition prepared by fermenting 5-20% by weight of yellow bark fruit and 80-95% by weight of fruit liquor soju, and the pharmaceutical composition is particularly effective in alleviating atopic inflammation or nervousness. Exert. At this time, the fermentation means a process useful for sufficiently leaching the medicinal ingredients, the fermentation period in this process is suitable for 2 to 18 months. If the fermentation period is less than two months, the efficacy is not exhibited more than 80%, if the fermentation is over 18 months, there is a problem that the efficacy is rather poor. In addition, in the present invention, the mixing of the yellow wall and soju is to prevent the decay of the yellow wall, to maintain the freshness and increase the drug effect.

The pharmaceutical composition of the present invention is prepared by removing the foreign matter adhering to the yellow wall fruits and washing the whole, then mixing 5 to 20% by weight of dried yellow wall fruits and 80 to 95% by weight of fruit liquor shochu and fermented at room temperature Can be.

The present invention also provides a pharmaceutical composition comprising 10 to 20% by weight of yellow wall fruits and 80 to 90% by weight of water, wherein the yellow wall fruits can be used in powder. Such pharmaceutical compositions are particularly effective in alleviating dandruff and scalp infections.

The pharmaceutical composition of the present invention removes foreign matters attached to the yellow wall fruits and washes the whole, and then powdered dried yellow wall fruits and powdered yellow wall fruits 10 to 20% by weight and water 80 to 90% by weight It can be prepared by mixing uniformly.

The present invention also provides a pharmaceutical composition prepared by mixing 20 to 40% by weight of yellow bark leaves and 60 to 80% by weight of water and heating at 100 to 150 ° C., which has an excellent effect on the relaxation of blotch. At this time, when the heating temperature is carried out below 100 ℃ can not obtain the desired effect, when the temperature is carried out to more than 150 ℃ there is a problem that the efficacy is lowered.

The pharmaceutical composition of the present invention can be obtained by removing the foreign matter adhering to the leaves of the yellow wall and washing the whole, and then heated at 100 to 150 ℃ for 24 hours to prepare a yellow wall extract, filtration and concentration.

In addition, the pharmaceutical composition of the present invention may be added to the herbal medicine hot water extract, the herbal medicine hot water extract is pressure (MPa / kgf / / one or more herbal medicines selected from the group consisting of red ginseng, sewage, bellflower, cheonggung, apricot seeds and licorice Cm 2) 1.8 and a temperature of 120 to 130 ℃ can be obtained by hot water extraction for 2 to 3 hours.

Despite the effectiveness as described above, the composition of the present invention containing the yellow fruit or leaves does not show any toxicity, such as acute toxicity, and no side effects on liver function in the test using rats.

The pharmaceutical formulations can be prepared according to conventional methods using the compositions of the present invention. In the preparation of the formulations, it is preferable to mix or dilute the active yellowberry fruit or leaves with the carrier, or to enclose it in a carrier in the form of a container. When the carrier is used as a diluent, it may be a solid, semisolid or liquid substance which acts as a vehicle, excipient or medium for the active ingredient.

Thus, the formulations may be in the form of tablets, pills, powders, assays, elixirs, suspensions, emulsions, solutions, syrups, aerosols, creams, soft or hard gelatin capsules, sterile injectables, sterile powders and the like. Examples of suitable carriers, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, Propylhydroxybenzoate, talc, magnesium stearate and mineral oils. The formulations may additionally include fillers, anti-coagulants, lubricants, wetting agents, perfumes, emulsifiers, preservatives, and the like. Compositions according to the invention can be formulated using methods well known in the art to provide rapid, sustained or delayed release of the active ingredient after administration to a mammal.

The composition according to the invention can be administered via several routes including oral, transdermal, subcutaneous, intravenous or intramuscular. For humans, typical daily dosages can range from 5 to 500 mg / kg body weight, preferably 100 to 250 mg / kg body weight, and can be administered once or in divided doses. However, the actual dosage should be determined in light of several relevant factors such as the route of administration, the age, sex and weight of the patient, the state of health and the severity of the disease.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, these Examples are only for illustrating the present invention, and the scope of the present invention is not limited thereto.

In addition, in the examples below, the following percentages for solids and solid mixtures, liquids and liquids, and liquids and solids are based on weight / weight, volume / volume and weight / volume, respectively, and all reactions are carried out at room temperature unless otherwise noted. It was.

Example 1 Preparation of Composition Containing Yellow Wall Fruit

600 g of yellow bark fruit and 2.7 liters of fruit liquor were mixed and fermented at room temperature for 3 months to prepare a composition containing the yellow bark fruit.

Example 2: Preparation of a Composition Containing Yellow Wall Fruit

500 g of yellow bark fruit and 2 liters of fruit liquor were mixed and fermented at room temperature for 3 months to prepare a composition containing the yellow bark fruit.

Example 3 Preparation of a Composition Containing Yellow Wall Fruit

200 g of yellow fruit and 1.1 liter of water were mixed to prepare a composition containing yellow fruit.

Example 4 Preparation of a Composition Containing Yellow Pine Fruit

After powdering the yellow wall leaves, 500 g of powdered yellow wall leaves and 1 liter of water were mixed, and then heated at 100 ° C. for 1 day to prepare a composition containing the yellow wall leaves.

Example 5 Preparation of a Composition Containing Yellow Pine Fruit

The yellow wall fruit was powdered and 200 g of the powdered yellow wall fruit and 0.5 liter of water were mixed to prepare a composition containing the yellow wall fruit.

Test Example 1 Measurement of Atopic Infection Relief Effect

40 subjects with atopic dermatitis were divided into two groups of 20 persons each, and the composition of the present invention prepared in Example 1 was used twice a day for morning and evening after washing for 8 weeks, and after 8 weeks, atopy The degree of relief and pruritus of the salt were determined by visual and interrogation responses. No special treatment was given to the control group. The results are shown in Table 1 below. The figures in the following table are the number of subjects. Here, in the skin area of the test subjects having atopic dermatitis of the experimental group that tested the composition of the present invention, if the atopic dermatitis skin area was reduced by more than 30%, it was very alleviated, so that from 20% to 30% The test results were prepared with relaxation, with a slight relaxation of over 10% to 20%, with less than 10% unmitigated. At this time, as shown in Table 1, it can be seen that most of the relaxation was over 20%.

Very relaxed Relaxed Slightly relaxed Not mitigated Experimental group 9 7 4 0 Control group 0 0 2 18

Test Example 2: Determination of dandruff or scalp relieving effect

40 test subjects with dandruff and scalpitis were divided into two groups of 20 people each, and the composition of the present invention prepared in Example 3 was applied to the scalp for 8 weeks twice a day in the morning and evening after washing the hair. Eight weeks later, the degree of relief and pruritus of dandruff and scalpitis were determined by visual and Q & A. No special treatment was given to the control group. The results are shown in Table 2 below. The figures in the following table are the number of subjects. Here, in the area of the test subjects with dandruff and scalpitis of the experimental group that tested the composition of the present invention, after the test, if the area of skin where dandruff and scalpitis is present is reduced by more than 30% is very alleviated, Test results were made with less than 20% to 30% relaxed, more than 10% to 20% slightly relaxed, and less than 10% unmitigated. At this time, as shown in Table 2, it was confirmed that most of the mitigation effect is over 20%.

Very relaxed Relaxed Slightly relaxed Not mitigated Experimental group dandruff 11 8 One 0 Scalpitis 9 9 2 0 Control group dandruff 0 0 3 17 Scalpitis 0 0 2 18

Experimental Example 3: Measurement of Bacterial Mitigation Effect

40 test subjects with blemishes on the skin were divided into 2 groups of 20 people each, and the composition of the present invention prepared in Example 4 was administered 100ml twice a day for 8 weeks each morning and evening. The degree of relief and pruritus were determined by visual and interrogation responses. No special treatment was given to the control group. The results are shown in Table 3 below. The figures in the following table are the number of subjects. Here, in the area of the test subjects having the black mushroom of the experimental group tested the composition of the present invention, the case where the skin area in which the black mushroom is present is reduced by more than 30% is very alleviated, more than 20% to 30% The test results were prepared by mitigating until 10%, but slightly mitigating by more than 10% and less than 10%. At this time, as shown in Table 2, it was confirmed that most of the mitigation effect is over 20%.

Very relaxed Relaxed Slightly relaxed Not mitigated Experimental group 12 7 One 0 Control group 0 One 2 17

Test Example 4 Measurement of Hair Loss Relief Effect

40 test subjects with hair loss symptoms were divided into two groups of 20 people each, and the composition of the present invention prepared in Example 5 was applied to the scalp twice a day for 8 weeks, morning and evening, after washing the hair, and hair loss after 8 weeks. The degree of relaxation and pruritus were determined by visual and Q & A. No special treatment was given to the control group. The results are shown in Table 4 below. Here, the evaluation criteria are 5 points for hair loss at hair loss, subjective symptoms, and visual effects, and 5 points for remarkable effects, 4 points for moderate, 3 points for mild, 2 points for constant, and 1 point for worsening hair loss. After the evaluation, the overall judgment was made as an average value.

Experimental group Control group Hair Loss on Tricycle 4.5 2 Subjective symptoms 5 2 Visual judgment 4.5 2 Synthesis 4.8 2

As described above, it was found that the pharmaceutical composition containing the fruit or leaf of the yellow bark produced in accordance with the present invention has an alleviating effect on atopic dermatitis, dandruff, scalpitis or blotch, and hair loss.

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The pharmaceutical composition containing the fruit or leaves of the yellow bark prepared according to the present invention has a relieving effect on atopic dermatitis, dandruff, scalpitis or blotch and can be usefully used in various formulations in the art.

Claims (10)

A creamy composition for improving atopic dermatitis prepared by fermenting for 5 months by mixing 5 to 20% by weight of yellow fruit and 80 to 95% by weight fruit liquor. A cream-like composition for improving dandruff or scalp salt comprising 10-20% by weight of yellow fruit and 80-90% by weight of water. 20 to 40% by weight of the leaves of yellow bark and 60 to 80% by weight of water, the cream composition for improving the blotch prepared by heating at 100 to 150 ℃. delete delete delete delete delete delete delete