JPH1160449A - Hair tonic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition which is utilized in fields of medicines, quasi-drugs and cosmetics and exerts low irritation to scalp and the like and has excellent hair-restoring effect such as depiratory prevention effect and hair-growing effect by formulating an alkaloid-rich fraction prepared from plants of the family Rutaceae. SOLUTION: This hair tonic composition is obtained by formulating an alkaloid-rich fraction prepared from plants of the family Rutaceae the genus Phellodendron (preferably Phellodendrona murense) preferably in an amount of 0.005-10 wt.% based out the whole weight of the composition. The objective composition can be prepared in dosage forms, e.g. liquid, emulsion, ointment, etc., applicable to scalp. On this composition, minoxidil, diazoxide and various antiandrongens, e.g. oxendlone, nicotinic acid, etc. can be blended as other components, and in addition additives, surfactants, perfumes, antioxidants, ultraviolet ray absorbents and pigments can also be blended.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is used in the field of hair restorer, more particularly in the field of pharmaceuticals, quasi-drugs or cosmetics, and has low irritation to the scalp and the like, and has excellent anti-hair loss and hair growth effects. The present invention relates to a hair restorer composition having a hair action.

[0002]

2. Description of the Related Art Conventionally, the cause of baldness and hair loss has been removed.
Alternatively, a hair nourishing cosmetic in which various agents are blended in order to reduce the amount is known. In these hair-growing cosmetics, for example, in order to improve the blood flow to the hair root, assembly extract or an acetylcholine derivative is blended, or a female hormonal agent such as estradiol as an anti-androgen is blended. And hinokitiol for improving scalp metabolism are used for preventing and treating alopecia. However, the mechanism of hair loss and hair growth is very complicated, and as with conventional hair nourishes, hair loss prevention and hair growth can be satisfied only by adding assembly extracts etc. to promote blood circulation and reduce male hormone activation. No effect has been obtained.

[0003] On the other hand, yellowfin (Phellodendron amurense), a plant belonging to the genus Phellodendron, of the citrus family, is known as a base plant of crude herbal medicine oak, and has been used as a medicine and cosmetics for a long time. Antibacterial action is known (Chinese Traditional Medicine Dictionary, Volume 1, 1
58-163). Further, it has been disclosed that yellowfin has an effect of preventing hair loss and promoting hair growth when combined with a rose extract or the like (JP-A-3-284).
614), the effect of which is not yet satisfactory. A hair restoration composition using reticuline as an alkaloid is disclosed in JP-A-8-217640.

[0004]

DISCLOSURE OF THE INVENTION An object of the present invention is to provide a hair restorer composition containing a high alkaloid fraction prepared from a plant belonging to the genus Phellodendron of the Rutaceae family and having remarkable anti-hair loss and hair growth effects. That is.

[0005]

Means for Solving the Problems In view of such circumstances, the present inventors have conducted intensive studies on plants belonging to the genus Phellodendron of the family Rutaceae, and as a result, the high alkaloid fraction prepared therefrom has excellent hair restoration. The inventors have found that the present invention has an effect, and have completed the present invention.

That is, the present invention relates to a citrus family Phelloden
An object of the present invention is to provide a hair restorer composition comprising a high alkaloid fraction prepared from a plant of the genus dron. ADVANTAGE OF THE INVENTION According to this invention, the above-mentioned problems are solved and the hair restoration composition which has the effects of excellent hair loss prevention, hair growth, etc. can be provided. In addition, the use of the fraction of the present invention can further enhance safety as compared with the case where a high-purity alkaloid component is used.

[0007]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Rutaceae Phellod used in the present invention
The plants of the genus endron are not particularly limited, and examples include yellowfin (Phellodendron amurense) and white pheasant (Phellodendron chinese). Particularly preferred are yellowfin (Phellodendron amurense), and these plants are used alone or in combination of two species. The above plants may be mixed,
The fresh tissue or dried material of a portion such as a flower, bark, fruit, leaf, root or stem can be chopped or crushed if necessary, and used for the following high alkaloid fraction preparation operation.

[0008] The high alkaloid fraction used in the present invention contains an alkaloid such as berberine as a main component in an amount of, for example, 1 to 20% by weight as a dry solid content, and has an orange color by a Dragendorff reagent and potassium chloride iodide. The reagent turns blue-violet, and the methanol solution is applied to a TLC plate (adsorption layer: silica gel, product name: Kiesel gel 60F25).
4 (Merck)) (chloroform: methanol (4:
1)), and when observed under UV (254 nm), it was observed as one oval spot near Rf = 0.21, and was insoluble in water and soluble in alcohols such as methanol and ethanol. Yes, and the dried fraction is powdery and has a yellow to orange color. The high alkaloid fraction of the present invention is obtained, for example, by mixing a part of the above-mentioned dried bark of the plant of the genus Phellodendron with a lower alcohol such as methanol and ethanol; a fatty acid ester such as methyl acetate and ethyl acetate; Polar organic solvent 3 to 30 selected from alkyl halides such as chloride
The mixture was extracted with gentle stirring at room temperature to 80 ° C for about 1 to 10 hours, and the extraction solvent was evaporated to dryness.
1 part of the obtained residue is added with 1 to 3 parts of an acidic aqueous solution such as hydrochloric acid, sulfuric acid, or citric acid having a pH of 3 or less, and extracted at room temperature for about 10 minutes to 1 hour. It is obtained by adjusting the pH to 9 to 10 by adding an aqueous solution of potassium hydroxide, sodium carbonate, aqueous ammonia or the like, extracting again with a polar organic solvent such as ether or chloroform, and then removing the solvent. This high alkaloid fraction can be used as it is in the form of a powder or in the form of a solution dissolved in alcohol or the like.

In the hair restorer composition of the present invention, the amount of the high alkaloid fraction is not particularly limited, but the solid content of the high alkaloid fraction is usually 0.001 to 20% by weight based on the total amount of the hair restorer composition. , Preferably 0.005 to
10% by weight is blended. The hair restorer of the present invention can be produced according to a known method, and can be in any form applicable to the scalp, such as a liquid, an emulsion or an ointment containing the above-mentioned components.

[0010] The hair restorer composition of the present invention also comprises
Minoxidil, diazoxide, various antiandrogens such as oxendrone, 4-androstene-3,17-dione-17-cyclic ethyleneketal derivative, and other nicotinic acid as other components for enhancing the hair growth promoting effect. And its derivatives, carbronium chloride, vitamin E acetate, vitamin E nicotine, pantothenic acid and its derivatives, biotin, glycyrrhizic acid,
Glycyrrhetinic acid, Cordyceps sinensis extract, Korean carrot extract, assembly extract, capsicum extract, cepharanthin, placenta extract, ethinyl estradiol, carpronium chloride, photosensitizer, other vitamins and amino acids can also be added at the same time. Furthermore, additives usually used for hair restoration, for example, hinokithio-
, Hexachlorophen, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and bitionol, cooling agents such as menthol, salicylic acid, zinc and its derivatives, lactic acid And its drugs such as alkyl esters, olive oil, squalane, liquid paraffin,
Isopropyl myristate, higher fatty acid, higher alcohol
Oil and other surfactants, fragrances, antioxidants,
An ultraviolet absorber, a dye, ethanol, water, a humectant, a thickener, and the like can be appropriately compounded within a range that does not impair the effects of the present invention.

[0011]

EXAMPLES The present invention will be described in more detail with reference to Preparation Examples, Test Examples and Examples, but the present invention is not limited thereto. Preparation Example 1 First, a methanol extract was prepared from 100 g of dried bark strips of yellowfin by a conventional method. Then, extract 2%
After dissolving in sulfuric acid and removing insoluble matter by filtration, extraction with ether was carried out to remove acidic substances, the acidic aqueous layer was made alkaline with sodium carbonate, extracted with ether, and the ether layer was dried over anhydrous potassium carbonate and then etherified. Was removed to obtain 0.65 g of a high alkaloid fraction.

Test Example 1 Qualitative test by TLC Take 20 μl of a methanol solution of the above high alkaloid fraction and place it on a TLC plate (adsorption layer: silica gel; product name: Ki)
esel gel 60F254 (manufactured by Merck)), and chloroform: methanol = 4: 1 is used as a developing solvent for about 15 minutes.
cm. After air drying, a UV lamp (254 nm) and a Dragendorff reagent were sprayed and observed. A single oblong spot was observed near Rf = 0.21 by the UV lamp, and the spot was colored orange-red by the Dragendorff reagent, confirming that the spot contained alkaloids. .

Test Example 2 Test for Promoting Hair Growth by C3H Mice The back of an 8-week-old C3H male mouse was shaved to a size of about 2 × 4 cm, and from the next day, the extract obtained in Preparation Example 1 was 1% by weight. The 50% ethanol solution was applied once a day to the shaved part once a day for 15 days, and the effect on hair regeneration at the site was examined. The effect of each plant extract was expressed as a relative ratio when the hair weight of the control group (the group coated with 50% ethanol) was 100%. Table 1 shows the results.

[0014]

Table 1 Hair weight Hair growth Specimen Relative value (%) Acceleration rate (%) 50% ethanol (control group) 100-280 180 Yellowfin methanol extract obtained in Preparative Example 1 Obtained in Preparative Example 1 388 288 High alkaloid fraction of yellowfin As shown in Table 1, the high alkaloid fraction has an excellent hair growth promoting effect as compared with the control, and the effect is higher than that of the methanol extract. A similar effect was also observed in the high alkaloid fraction of pheasant obtained in Preparation Example 2 below.

PREPARATION EXAMPLE 2 A methanol extract was prepared from 100 g of dried bark of an azalea by a conventional method. The extract was dissolved in 2% sulfuric acid to remove insolubles by filtration, followed by extraction with ether to remove acidic substances. The acidic aqueous layer was made alkaline with sodium carbonate, extracted with ether, and extracted with ether. Was dried over anhydrous potassium carbonate and the ether was removed to obtain 0.52 g of a high alkaloid fraction.

Example 1 A hair tonic was produced according to the following formulation by a conventional method. Component Blended amount (% W / V) Yellowfin alkaloid fraction 1 (Preparation Example 1) 95% ethanol 70 Solubilizer 1 (polyoxyethylene [60EO] hydrogenated castor oil) Propylene glycol 5 Fragrance Trace amount Purified water Remainder Total 100

Example 2 A lotion was prepared according to the following formulation by a conventional method. Ingredient Content (% W / V) Yellowfin alkaloid fraction 0.1 (Preparation Example 1) Hydroxyethylcellulose 0.4 Ethanol 5 1,3-Butanediol 5 Paraoxybenzoic acid ester 0.2 Perfume Trace amount Purification Water balance 100

Example 3 According to the following formulation, a hair cream was produced by a conventional method. Component Blended amount (% W / V) High alkaloid fraction of yellowfin 1 (Preparation example 1) Beeswax 5 Lanolin 4 Vaseline 5 Liquid paraffin 33 Emulsifier 4 (Polyoxyethylene [20EO] sorbitan monostearate) Paraoxybenzoic acid Ester 0.2 Borax 1 Fragrance trace amount Purified water Remainder Total 100

Example 4 A hair tonic was produced according to the following formulation by a conventional method. Ingredients Blended amount (% W / V) High alkaloid fraction of Ohashi 1 (Preparation Example 2) 95% ethanol 70 Solubilizer 1 (Polyoxyethylene [60EO] hydrogenated castor oil) Propylene glycol 5 Perfume Trace amount Purified water Remaining Total 100

Example 5 A lotion was produced according to the following formulation by a conventional method. Ingredients Blended amount (% W / V) High alkaloid fraction of Oyster 0.1 (Preparation Example 2) Hydroxyethylcellulose 0.4 Ethanol 5 1,3-Butanediol 5 Paraoxybenzoate 0.2 Perfume Trace amount Purified water Remainder Total 100

Example 6 A hair cream was produced according to the following formulation by a conventional method. Ingredients Blended amount (% W / V) High alkaloid fraction of Ohiju 5 (Preparation Example 2) Beeswax 5 Lanolin 4 Vaseline 5 Liquid paraffin 33 Emulsifier 4 (Polyoxyethylene [20EO] sorbitan monostearate) Paraoxybenzoate 0 .2 Borax 1 Perfume trace amount of purified water Remainder 100

[0022]

According to the present invention, the citrus family Phellodendr
A composition characterized by containing a high alkaloid fraction prepared from a plant of the genus on has a strong hair-growth effect, and can significantly exert effects such as hair loss prevention and hair growth promotion. .

Claims (2)

[Claims] 1. A hair restorer composition comprising a high alkaloid fraction prepared from a plant belonging to the genus Phellodendron of the family Rutaceae. 2. The hair restorer composition according to claim 1, wherein the plant belonging to the genus Phellodendron in the family Rutaceae is Phellodendronamurense.