KR101156263B1 - 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법 - Google Patents

폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법 Download PDF

Info

Publication number
KR101156263B1
KR101156263B1 KR1020097026328A KR20097026328A KR101156263B1 KR 101156263 B1 KR101156263 B1 KR 101156263B1 KR 1020097026328 A KR1020097026328 A KR 1020097026328A KR 20097026328 A KR20097026328 A KR 20097026328A KR 101156263 B1 KR101156263 B1 KR 101156263B1
Authority
KR
South Korea
Prior art keywords
vwf
purine
propeptide
mature
incubation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020097026328A
Other languages
English (en)
Korean (ko)
Other versions
KR20100028042A (ko
Inventor
볼프강 문트
아르투르 미테레르
마인하르트 하쌀라헤르
크리스타 마이어
Original Assignee
박스터 헬쓰케어 에스.에이.
백스터 인터내셔널 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 박스터 헬쓰케어 에스.에이., 백스터 인터내셔널 인코포레이티드 filed Critical 박스터 헬쓰케어 에스.에이.
Publication of KR20100028042A publication Critical patent/KR20100028042A/ko
Application granted granted Critical
Publication of KR101156263B1 publication Critical patent/KR101156263B1/ko
Assigned to 박스앨타 게엠베하, 박스알타 인코퍼레이티드 reassignment 박스앨타 게엠베하 권리의 전부이전등록 Assignors: 박스터 헬쓰케어 에스에이, 백스터 인터내셔널 인코포레이티드
Assigned to 다케다 야쿠힌 고교 가부시키가이샤 reassignment 다케다 야쿠힌 고교 가부시키가이샤 권리의 전부이전등록 Assignors: 박스알타 인코퍼레이티드, 박스앨타 게엠베하
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020097026328A 2007-05-18 2008-05-16 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법 Active KR101156263B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93089107P 2007-05-18 2007-05-18
US60/930,891 2007-05-18
PCT/US2008/006291 WO2008143977A1 (en) 2007-05-18 2008-05-16 Method for producing mature vwf from vwf pro-peptide

Publications (2)

Publication Number Publication Date
KR20100028042A KR20100028042A (ko) 2010-03-11
KR101156263B1 true KR101156263B1 (ko) 2012-06-13

Family

ID=39666205

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097026328A Active KR101156263B1 (ko) 2007-05-18 2008-05-16 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법

Country Status (16)

Country Link
US (1) US8058411B2 (https=)
EP (1) EP2152735B1 (https=)
JP (2) JP5053435B2 (https=)
KR (1) KR101156263B1 (https=)
CN (1) CN101679496B (https=)
AU (1) AU2008254522B2 (https=)
BR (1) BRPI0811649B8 (https=)
CA (1) CA2684151A1 (https=)
DK (1) DK2152735T3 (https=)
ES (1) ES2539284T3 (https=)
HU (1) HUE025257T2 (https=)
MX (1) MX2009012387A (https=)
NZ (1) NZ581582A (https=)
PL (1) PL2152735T3 (https=)
PT (1) PT2152735E (https=)
WO (1) WO2008143977A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2821711C (en) * 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
US20140276101A1 (en) * 2013-03-14 2014-09-18 Boston Scientific Scimed, Inc. Medical device for detecting a target and related methods of use
AR102048A1 (es) 2014-08-12 2017-02-01 Baxalta Inc Producción del factor x completamente procesado y funcional en un sistema de expresión de mamífero de secreción de furina
EP3642225A1 (en) 2017-06-23 2020-04-29 Baxalta Incorporated Purification of factor viii subspecies
CA3094644A1 (en) * 2018-03-21 2019-09-26 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775750A2 (de) * 1995-11-24 1997-05-28 IMMUNO Aktiengesellschaft Herstellung von Proteinen aus Pro-Proteinen durch Fusionsproteine abgeleitet von Furin oder Furinanalogen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT407750B (de) 1999-02-19 2001-05-25 Immuno Ag Verfahren zur herstellung einer vwf-präparation
CA2591852A1 (en) * 2004-12-27 2006-07-06 Baxter International Inc. Polymer-von willebrand factor-conjugates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775750A2 (de) * 1995-11-24 1997-05-28 IMMUNO Aktiengesellschaft Herstellung von Proteinen aus Pro-Proteinen durch Fusionsproteine abgeleitet von Furin oder Furinanalogen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Thrombosis and thrombolysis Vol.8:197-205 (1999) *

Also Published As

Publication number Publication date
NZ581582A (en) 2012-02-24
AU2008254522B2 (en) 2012-07-12
AU2008254522A2 (en) 2010-02-18
JP2010527588A (ja) 2010-08-19
EP2152735B1 (en) 2015-03-18
PT2152735E (pt) 2015-07-21
WO2008143977A1 (en) 2008-11-27
MX2009012387A (es) 2010-02-10
US8058411B2 (en) 2011-11-15
US20090029918A1 (en) 2009-01-29
DK2152735T3 (en) 2015-04-20
CN101679496B (zh) 2013-03-13
JP2012210226A (ja) 2012-11-01
JP5053435B2 (ja) 2012-10-17
PL2152735T3 (pl) 2015-08-31
HK1144577A1 (en) 2011-02-25
ES2539284T3 (es) 2015-06-29
KR20100028042A (ko) 2010-03-11
BRPI0811649A2 (pt) 2014-11-11
AU2008254522A1 (en) 2008-11-27
EP2152735A1 (en) 2010-02-17
BRPI0811649B8 (pt) 2021-05-25
BRPI0811649B1 (pt) 2020-11-17
CN101679496A (zh) 2010-03-24
HUE025257T2 (en) 2016-03-29
CA2684151A1 (en) 2008-11-27

Similar Documents

Publication Publication Date Title
US10626431B2 (en) Method for improved isolation of recombinantly produced proteins
US20170065686A1 (en) Composition Exhibiting a von Willebrand Factor (vWF) Protease Activity Comprising a Polypeptide Chain with the Amino Acid Sequence AAGGILHLELLV
US5932706A (en) Antibodies specific for a haemostatic protein their use for isolating protein, haemostatic compositions devoid of proteolytic cleavage products of the protein
US20090169553A1 (en) Novel Protein Fusion/Tag Technology
EP2373677B1 (en) Polypeptide purification
KR101156263B1 (ko) 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법
JP2010527588A5 (https=)
EP2526115B1 (en) Purification of blood coagulation factors
CN108699133B (zh) 从血液产品分离因子viii的方法
JPH0736755B2 (ja) プラスミノーゲン・アクチベーター前駆体含有組成物
HK1144577B (en) Method for producing mature vwf from vwf pro-peptide
JP2008532536A (ja) 新規の非タンパク分解起源の可溶性ｅｐｃｒタンパク質およびその使用
AU2012216707A1 (en) Method for Producing Mature VWF From VWF Pro-peptide
HK40007078A (en) Method for isolation of recombinantly produced proteins

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20091217

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
A302 Request for accelerated examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20120112

Comment text: Request for Examination of Application

PA0302 Request for accelerated examination

Patent event date: 20120112

Patent event code: PA03022R01D

Comment text: Request for Accelerated Examination

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20120409

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20120607

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20120607

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20150522

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20150522

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20160526

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20160526

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20170529

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20170529

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20180601

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20180601

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20190603

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20190603

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20200601

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20200601

Start annual number: 9

End annual number: 9

FPAY Annual fee payment

Payment date: 20210525

Year of fee payment: 10

PR1001 Payment of annual fee

Payment date: 20210525

Start annual number: 10

End annual number: 10

FPAY Annual fee payment

Payment date: 20220520

Year of fee payment: 11

PR1001 Payment of annual fee

Payment date: 20220520

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20240527

Start annual number: 13

End annual number: 13