KR101059898B1 - 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에 영향을 미치는 인터루킨-1 좌의 기능적 다형성 - Google Patents

염증성 질환 및 감염성 질환에 대한 감수성 및 전사에 영향을 미치는 인터루킨-1 좌의 기능적 다형성 Download PDF

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KR101059898B1
KR101059898B1 KR1020107016833A KR20107016833A KR101059898B1 KR 101059898 B1 KR101059898 B1 KR 101059898B1 KR 1020107016833 A KR1020107016833 A KR 1020107016833A KR 20107016833 A KR20107016833 A KR 20107016833A KR 101059898 B1 KR101059898 B1 KR 101059898B1
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disease
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sequence
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디 와일리
고든 더블유 더프
나즈닌 아지즈
청 밍 시에
케네스 에스 코른만
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인터레우킨 제네틱스, 인코포레이티드
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
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KR1020107016833A 2001-11-19 2002-11-19 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에 영향을 미치는 인터루킨-1 좌의 기능적 다형성 Expired - Fee Related KR101059898B1 (ko)

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US33168101P 2001-11-19 2001-11-19
US60/331,681 2001-11-19
US38602002P 2002-06-05 2002-06-05
US60/386,020 2002-06-05
PCT/US2002/037222 WO2003044176A2 (en) 2001-11-19 2002-11-19 Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases

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KR1020047007653A Division KR101019131B1 (ko) 2001-11-19 2002-11-19 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에영향을 미치는 인터루킨-1 좌의 기능적 다형성

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KR1020047007653A Expired - Fee Related KR101019131B1 (ko) 2001-11-19 2002-11-19 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에영향을 미치는 인터루킨-1 좌의 기능적 다형성
KR1020107016833A Expired - Fee Related KR101059898B1 (ko) 2001-11-19 2002-11-19 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에 영향을 미치는 인터루킨-1 좌의 기능적 다형성

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EP (1) EP1463745A4 (enExample)
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KR (2) KR101019131B1 (enExample)
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CA (1) CA2467717A1 (enExample)
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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820383B2 (en) 1997-03-10 2010-10-26 Interleukin Genetics, Inc. Method for diagnosing myocardial infarction
GB9711040D0 (en) * 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
JP2003508022A (ja) * 1999-06-30 2003-03-04 インターリューキン ジェネティックス インコーポレイテッド Ｉｌ−１炎症性ハプロタイプと関連する病気の診断および治療方法
US20080311581A1 (en) * 2001-11-19 2008-12-18 David Wyllie Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases
US20070264645A1 (en) * 2002-01-25 2007-11-15 Kenneth Kornman IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
PT1549770E (pt) * 2002-09-30 2008-06-24 Novartis Ag Métodos para prever aumentos de colesterol durante terapia imunossupressora
US20050175721A1 (en) * 2004-02-06 2005-08-11 Brovelli Ernesto A. Method of augmenting the immune-modulatory activity of standardized Echinacea preparations
ES2523147T3 (es) * 2004-02-26 2014-11-21 Baylor Research Institute Composiciones y métodos para el tratamiento sistémico de la artritis
ATE490341T1 (de) * 2004-05-03 2010-12-15 Interleukin Genetics Inc Diagnostika und therapeutika für mit einem entzündlichen il-1-haplotyp assoziierte krankheiten
WO2006022277A1 (ja) * 2004-08-24 2006-03-02 Fujifilm Corporation 表面プラズモン共鳴分析における解離定数の算出方法
JP2006262826A (ja) * 2005-03-25 2006-10-05 Institute Of Physical & Chemical Research インターロイキン−１受容体２遺伝子の多型に基づく炎症性疾患の検査法
EP1951903A2 (en) * 2005-10-25 2008-08-06 Interleukin Genetics, Inc. The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes
JP4870976B2 (ja) * 2005-11-10 2012-02-08 株式会社Ｄｎａチップ研究所 全血を用いた自己免疫疾患の検査方法
CA2668722A1 (en) * 2006-11-15 2008-05-22 Interleukin Genetics, Inc. The il-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same
EP2217725A2 (en) * 2007-11-08 2010-08-18 Interleukin Genetics, Inc. Diagnostics for aging-related dermatologic disorders
US10894985B2 (en) 2016-01-12 2021-01-19 Sitokine Limited Methods for predicting response to treatment
KR102543907B1 (ko) * 2016-06-17 2023-06-15 서울대학교산학협력단 치주질환 위험도 평가용 유전자 마커
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
JP7097855B2 (ja) * 2019-04-24 2022-07-08 ジェネシスヘルスケア株式会社 歯周病のリスクを判定する方法
EP3980561A1 (en) 2019-06-06 2022-04-13 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
US20230277634A1 (en) * 2020-08-17 2023-09-07 The Regents Of The University Of California Application of microbial glycosidase as an anti-viral therapeutic, prognostic, and diagnostic

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) * 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4833080A (en) * 1985-12-12 1989-05-23 President And Fellows Of Harvard College Regulation of eucaryotic gene expression
US4998617A (en) * 1986-09-15 1991-03-12 Laura Lupton Inc Facial cosmetic liquid make up kit
US4968607A (en) * 1987-11-25 1990-11-06 Immunex Corporation Interleukin-1 receptors
US5459039A (en) * 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
US5593826A (en) * 1993-03-22 1997-01-14 Perkin-Elmer Corporation, Applied Biosystems, Inc. Enzymatic ligation of 3'amino-substituted oligonucleotides
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5686246A (en) * 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
GB9621129D0 (en) * 1996-10-10 1996-11-27 Duff Gordon W Detecting genetic predisposition to sight-threatening diabetic retinopathy
US6210877B1 (en) * 1997-03-10 2001-04-03 Interleukin Genetics, Inc. Prediction of coronary artery disease
US6524795B1 (en) 1997-03-10 2003-02-25 Interleukin Genetics, Inc. Diagnostics for cardiovascular disorders
GB9711040D0 (en) * 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
GB9723553D0 (en) * 1997-11-07 1998-01-07 Duff Gordon W Prediction of the risk of chronic obstructive airway disease
US6437216B1 (en) * 1997-11-13 2002-08-20 Interleukin Genetics Inc. Transgenic models of inflammatory disease
US6251598B1 (en) * 1998-10-30 2001-06-26 Interleukin Genetics, Inc. Methods for diagnosing sepsis
JP2003508022A (ja) 1999-06-30 2003-03-04 インターリューキン ジェネティックス インコーポレイテッド Ｉｌ−１炎症性ハプロタイプと関連する病気の診断および治療方法
EE200200149A (et) * 1999-09-21 2003-04-15 Astrazeneca Ab Kinasoliinühendid ja neid sisaldavad ravimkoostised
US6617329B2 (en) * 2000-08-26 2003-09-09 Boehringer Ingelheim Pharma Kg Aminoquinazolines and their use as medicaments
US6656946B2 (en) * 2000-08-26 2003-12-02 Boehringer Ingelheim Pharma Kg Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
US20030152947A1 (en) 2001-06-15 2003-08-14 Crossman David C. Methods for detecting and treating the early onset of aging-related conditions
TW200813014A (en) * 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
US6924285B2 (en) * 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
US8071304B2 (en) * 2003-04-05 2011-12-06 The Johns Hopkins University Methods for detecting a polymorphism in the NFKB1 gene promoter

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J Neurol Neurosurg Phsychiatry, October 2000, vol69, pp564-565.
Molecular and Cellular Biology, 1993, vol.13, No.11. pp6678-6689.

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CN101955943A (zh) 2011-01-26
JP2005509432A (ja) 2005-04-14
AU2002359431A8 (en) 2003-06-10
WO2003044176A2 (en) 2003-05-30
JP4492849B2 (ja) 2010-06-30
AU2002359431A1 (en) 2003-06-10
US20030235890A1 (en) 2003-12-25
JP2010029220A (ja) 2010-02-12
EP1463745A2 (en) 2004-10-06
CA2467717A1 (en) 2003-05-30
CN1753903A (zh) 2006-03-29
US20100279280A1 (en) 2010-11-04
KR20040066832A (ko) 2004-07-27
WO2003044176A9 (en) 2003-10-16
KR20100095652A (ko) 2010-08-31
EP1463745A4 (en) 2007-11-07
WO2003044176A8 (en) 2003-08-21
CN1753903B (zh) 2010-05-12
KR101019131B1 (ko) 2011-03-07
WO2003044176A3 (en) 2004-07-29

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