KR101006341B1 - Cosmetic Composition for Whitening of the Skin Comprising the Extract of Changium smyrnioides Wolff as Active Ingredient - Google Patents

Abstract

The present invention Myeongdangsam ( Changium smyrnioides Wolff ) relates to a cosmetic composition for skin whitening containing the extract as an active ingredient. The present invention also relates to a cosmetic method characterized in that the cosmetic composition is applied to human skin. According to the present invention, Myungdang ginseng extract has a melanin production inhibitory effect and tyrosinase activity inhibitory effect, and it was confirmed that it has an excellent effect in the whitening clinical experiment of the formulation containing the same. Therefore, the cosmetic composition of the present invention comprising Myeongdangsam extract having various functions as an active ingredient has a skin lightening effect.

Myeongdangsam, skin whitening, cosmetic composition

Description

Cosmetic composition for whitening skin containing Myeongdangsam extract as an active ingredient {Cosmetic Composition for Whitening of the Skin Comprising the Extract of Changium smyrnioides Wolff as Active Ingredient}

The present invention relates to a cosmetic composition for skin whitening containing Myeongdangsam extract as an active ingredient. The present invention also relates to a cosmetic method characterized in that the cosmetic composition is applied to human skin.

The skin is the outermost protective layer of the human body and protects it from external irritation and contamination, and plays an important role in maintaining homeostasis of the living body such as body temperature control and immune control. However, changes in physical and chemical stimuli, stress, and environmental pollution applied from the outside cause pigmentation of the skin and eventually cause spots, freckles, and blemishes on the skin. Melanin-producing melanocytes, which play an important role in determining skin color, are dendritic cells in the form of dark brown melanin in the basal layer of the epidermis, and the dendritic processes are elongated and elongated between the surrounding keratinocyte. .

The main role of melanin is to remove free radicals and free radicals from the skin and to protect the inside of the skin by blocking the transmission of ultraviolet rays. The starting material for making melanin is tyrosine, a type of amino acid normally present in the human body. Tyrosine is oxidized by an enzyme called tyrosinase in melanocytes to be converted into dopa (dihydroxy phenylalanine, DOPA), and the dopa is further oxidized and converted into dopaquinone (DOPA quinone). Dopaquinone is then subjected to automatic oxidation to finally produce a dark brown eumelanin. On the other hand, when dopaquinone encounters cysteine, cysteinyl DOPA is produced, resulting in reddish brown pheomelanin. The resulting melanin is carried in the melanosomes and delivered to keratinocytes.

The whitening agent can be classified into two types. The first is a substance that inhibits the production of melanin pigment by acting in the process of making melanin in melanocytes, and is representative of arbutin (Japanese Patent Application Laid-Open No. 4-93150). ), Vitamin C (Japanese Patent Laid-Open Publication No. 4-9320), and hydroquinone (Japanese Patent Laid-Open Publication (19202)) have various whitening effects. Of these, hydroquinone has the most powerful decolorizing effect, so it is included in dermatological ointments rather than cosmetics, and arbutin is less decolorizing than hydroquinone preparations. In recent years, the use of the material is limited due to genotoxicity, so the diversity of the material is very insufficient compared to other cosmetic materials. The action of vitamin C is to react with tyrosinase to reduce melanin intermediate dopaquinone to inhibit melanin production, and to reduce dark oxidized melanin to make light colored melanin. There are two kinds of action. It is widely known that vitamin C inhibits the function of pigment cells and is used in various whitening products. However, vitamin C is unstable because of its high safety but poor stability. There is. Therefore, various derivatives have been developed for the stabilization of vitamin C formulation. Plant extracts known to have a whitening effect include mulberry, baekbaekpi (mulberry root bark extract), licorice extract and the like.

Throughout this specification, numerous patent documents and articles are referenced and their citations are indicated. The disclosures of cited patent documents and articles are incorporated herein by reference in their entirety, so that the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained.

The present inventors searched various skin physiological activities of natural plant components in order to overcome the problems with the existing skin whitening agent and to provide a whitening cosmetic that improves melanin production inhibitory effect and improves skin pigmentation. Myungdang ginseng extract of the (Sanje family; 을 形 科) completed the present invention by confirming the melanin production inhibitory effect and tyrosinase activity inhibitory effect, and excellent skin whitening effect without skin irritation.

Therefore, an object of the present invention to provide a cosmetic composition for skin whitening containing Myeongdangsam extract as an active ingredient.

Another object of the present invention is to provide a cosmetic method comprising applying to the human skin a cosmetic composition containing the extract Myeongdangsam.

Other objects and advantages of the present invention will become apparent from the following examples and claims.

The above purpose is Changmyeongsam smyrnioides Wolff ) is achieved by a cosmetic composition for skin whitening containing the extract as an active ingredient.

Preferably, the extract of Myeongdangsam is contained as 0.001-30.0% by weight based on the total weight of the cosmetic composition.

Also preferably, the extract is selected from the group consisting of (a) water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate and 1,3-butylene glycol It is characterized by extraction using a solvent extraction method using a solvent, (b) supercritical extraction method or (c) ultrasonic extraction method.

Also preferably, the cosmetic composition is a group consisting of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant-containing cleansing, an oil, a powder foundation, an emulsion foundation, a wax foundation and a spray It is characterized by having the formulation selected from.

Another object of the present invention is achieved by a cosmetic method, characterized in that the cosmetic composition is applied to human skin.

The present invention relates to a cosmetic composition for skin whitening containing Myeongdangsam extract as an active ingredient. According to the present invention, Myeongdangsam extract is excellent in stabilizing effect of cell viability (Experimental Example 1), melanin production inhibitory effect (Experimental Example 2), tyrosinase activity inhibitory effect (Experimental Example 3). Therefore, the cosmetic composition of the present invention containing the Myeongdangsam extract having various functions as an active ingredient is excellent in the skin lightening effect (Experimental Example 4).

Changium, Myeongdangsam , belonging to the mountain family smyrnioides Wolff ) is a perennial herb and has two forms: root or fusiform or oval and elongated columnar. Stems are hollow and covered with white powder. The leaves growing at the base are divided into three extracts, two or three idols, and the final lobe is lanceolate, the petiole is long, and the base is long. Is sheath-shaped. Leaves growing on the upper part of the stem are sheath-shaped. In plural inflorescences, flowers are white, and inflorescences growing on the sides do not bear fruit. The flowering period is April to May and the fruiting season is May to June. Myeongdangsam is a long, columnar, fusiform or irregular, long block, 6 ~ 20cm long, 0.5 ~ 2cm in diameter. The surface is yellowish white or light brown with smooth or newly traced bones and beard roots, and some have reddish brown spots. It has a keratin cross section, and its shell is relatively thin, yellowish white, and easily separated from the wood part. Remove the stems, leaves, and beard roots in spring, boil in boiling water, take it out when the white seam disappears, remove the skin, and dry it in the sun to use as a medicinal herb. Nourishment tonic, pulmonary function enhancement, Jinhae expectoration is effective.

In the present specification, the extract of Myeongdangsam means that it is obtained by extracting from various organs or parts (eg, leaves, flowers, roots, stems, branches, shells and seeds, etc.) of the Myeongdangsam plant, preferably leaves, stems, branches , Bark or seed, more preferably leaves, branches or roots, most preferably means extracts obtained from the roots.

Myeongdangsam extract of the present invention can be prepared according to conventional methods known in the art, that is, under the conditions of conventional temperature and pressure, using a conventional solvent, preferably purified water, methanol, ethanol, glycerin Extracted using at least one extraction solvent selected from the group consisting of ethyl acetate, butylene glycol, propylene glycol, dichloromethane, chloroform, ethyl ether, butylene glycol, and hexane, more preferably ethanol, 70% ethanol Or extracted with water, most preferably 70% ethanol.

On the other hand, it is apparent to those skilled in the art that the extract of Myeongdangsam of the present invention can be obtained not only with the above-described extraction solvent but also with other extraction solvents.

In addition, the extract of the present invention includes not only the extract by the above-described extraction solvent, but also the extract that has undergone a conventional purification process. For example, decompression by carbon dioxide, extraction by supercritical extraction by high temperature, extraction by ultrasonic extraction, separation using ultrafiltration membranes with constant molecular weight cut-off values, various chromatography (size, charge, hydrophobicity or affinity) The active fraction obtained through various purification methods additionally carried out, such as separation by sex)) is also included in the extract of the present invention.

In another aspect, the present invention provides a composition for external application to the skin, characterized in that the extract is obtained by cold washing at room temperature, heat filtration, and further obtained by concentrating the solvent under reduced pressure or lyophilization.

In addition, Myeongdangsam extract of the present invention is contained 0.001-30.0% by weight, preferably 0.1-10.0% by weight based on the total cosmetic composition. When the content of the extract is less than 0.001% by weight, the whitening effect is extremely weak. When the content of the extract is greater than 30.0% by weight, the effect of increasing the content is insignificant, and there is a problem in the safety and stability of the formulation and is not economical.

Myeongdangsam extract of the present invention can achieve its effect by topical application or spraying on the skin. Therefore, according to one preferred aspect of the present invention, the composition of the present invention may be prepared in the form of cosmetic compositions such as creams, lotions and softening water or pharmaceutical compositions such as sprays and ointments.

Ingredients included in the cosmetic composition of the present invention as an active ingredient includes components conventionally used in cosmetic compositions in addition to the active ingredient, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, And carriers.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing It may be formulated as, oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, and especially in the case of spray, additionally chlorofluorohydrocarbon, Propellant such as propane / butane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, and microcrystals are used as carrier components. Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

In addition, the present invention provides a cosmetic method comprising applying to the human skin a cosmetic composition containing the extract Myeongdangsam of the present invention.

The cosmetic method of the present invention refers to all cosmetic methods for applying the cosmetic composition of the present invention to human skin. That is, all the methods known in the art for applying the cosmetic composition to the skin belong to the cosmetic method of the present invention.

The cosmetic composition of the present invention may be used alone or in duplicate, or may be used in combination with other cosmetic compositions other than the present invention. In addition, the cosmetic composition with excellent skin protection effect according to the present invention can be used according to a conventional method of use, the number of times of use can be varied according to the user's skin condition or taste.

When the cosmetic composition of the present invention is a soap, surfactant-containing cleansing or surfactant-free cleansing formulation, it may be wiped off, peeled off or washed with water after application to the skin. As a specific example, the soap is liquid soap, powdered soap, solid soap and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel and cleansing pack, the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotion, cleansing water and cleansing gel, but are not limited thereto.

When the cosmetic method comprising the extract of Myeongdangsam of the present invention is applied to human skin, a skin whitening effect can be obtained.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

Production Example  One. Myeongdangsam  Preparation of Extract

The dried and dried root of Myeongdang ginseng was refluxed three times for 5 hours with 70% (V / V) ethanol aqueous solution, and the mixture was cooled and then filtered through Whatman # 5 filter paper. The filtered extract was concentrated under reduced pressure and freeze dried at 50 ° C or lower. Myeongdangsam extract was prepared by dispersing / dissolving in a 50% butylene glycol solution such that the vacuum concentrate and the lyophilisate were 1%.

Experimental Example  One: MTT Cell survival rate experiment

This Experimental Example was tested by MTT method to determine the cell viability of Myeongdangsam extract obtained in Preparation Example 1. The MTT (3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl-tetrazolium bromide) assay is one of the methods used to detect cell growth. The water-soluble yellow tetrazolium salt MTT is a water-soluble blue violet insoluble in living cells. This test uses the ability of the mitochondria to reduce to formazan crystals. And, if the cell viability is more than 95% is stable to the cell is suitable for confirming the proper use concentration. MTT reagent (Sigma, USA) was dissolved in PBS (phosphate-buffered saline) in cells cultured for 24 hours in culture medium containing different concentrations of Myeongdangsam extract, and filtered in each well at a final concentration of 0.5 mg / ml. Added and incubated at 37 ° C. for 4 hours. The absorbance of MTT formazan was maximum at a wavelength of 570 nm, and 200 µl DMSO was added to dissolve it, and the absorbance was measured at 570 nm. As a result, the cell survival rate (%) is shown in Table 1 below.

Sample Name Treatment concentration (ppm) Cell survival rate (%) Myeongdangsam Extract (Manufacturing Example 1) 10 118.8 Myeongdangsam Extract (Manufacturing Example 1) 20 117.3 Myeongdangsam Extract (Manufacturing Example 1) 50 110.7 Myeongdangsam Extract (Manufacturing Example 1) 100 103.7 Myeongdangsam Extract (Manufacturing Example 1) 200 97.5

 As shown in the results of Table 1, Myeongdamsam extract of the present invention all showed excellent cell viability (%) of more than 95% at all concentrations tested, it can be seen that the cells are stable.

Experimental Example  2. Measurement of melanin production inhibitory effect using B16F1 melanogenesis cells

In order to confirm the whitening effect of Myeongdangsam extract obtained in Preparation Example 1, the whitening effect was determined by looking at the degree of inhibition of melanin production on B16F1 melanocytes. B16F1 melanocytes used in this experiment is a cell strain derived from the mouse, and secreted a black pigment called melanin. Samples were treated during the artificial culture of these cells to evaluate the degree of melanin black pigment reduction. B16F1 melanocytes used in the present experiment was used by receiving from the American Type Culture Collection (ATCC).

The melanin biosynthesis inhibitory effect of B16F1 melanogenesis cells was measured as follows. B16F1 melanocytes were dispensed in 6-well plates at a concentration of 1 X 10 ⁵ per well, adhered to cells, and treated with 72 mg of Dangdansam extract and melanocyte stimulating hormone in DMEM medium for a non-toxic concentration for 72 hours. Incubated. After 72 hours of incubation, the cells were detached with trypsin-EDTA, and the cells were counted and then centrifuged to recover the cells. Quantification of intracellular melanin was carried out with a slight modification of the method of Rotan: Cancer Res., 40: 3345-3350, 1980. The recovered cell pellets were dried at 60 ° C., and dissolved melanin extracted by adding 1N NaOH (10% DMSO), and then measured the absorbance of melanin at 490 nm with a microplate reader, and then quantified melanin to inhibit the rate of melanin production in the sample ( %) Was measured. Melanin production inhibition rate (%) of B16F1 melanogenesis cells was calculated by Equation 1, the values are shown in Table 2 below. The same experiment was conducted using hydroquinone and arbutin as positive controls to confirm the degree of inhibition of melanin production of Myungdang ginseng extract.

A: Melanin amount in wells without sample

B: Melanin amount in the wells to which the sample was added

Sample Name Treatment concentration (ppm) Melanin production inhibition rate (%) Myeongdangsam Extract (Manufacturing Example 1) 10 66.3 Myeongdangsam Extract (Manufacturing Example 1) 20 79.3 Myeongdangsam Extract (Manufacturing Example 1) 50 90.4 Myeongdangsam Extract (Manufacturing Example 1) 100 97.5 Myeongdangsam Extract (Manufacturing Example 1) 200 96.1 Hydroquinone 0.1% 60.4 Arbutin 0.1% 60.4

As shown in the results of Table 2, when the Myeongdangsam extract was treated with 10ppm to 200ppm it was confirmed that the melanin production inhibitory effect than the 0.1% experimental concentration of the positive control hydroquinone and arbutin.

Experimental Example  3. Tyrosinase  Activity inhibition measurement

Tyrosinase was isolated and purified from mushrooms and purchased from sigma (USA). Myeongdangsam extract was prepared according to the method of Preparation Example 1 was used after dissolving in a suitable concentration in 0.1M sodium phosphate buffer (pH 6.5). Add 220 μl of 0.1 M phosphate buffer (pH 6.5), 20 μl of sample solution, and 20 μl of mushroom tyrosinase (1500 U / mL) solution. 40 μl of 1.5 mM tyrosine solution was added to the solution and reacted at 37 ° C. for 10-15 minutes. Then, the absorbance is measured at 490 nm using an ELISA reader. Add 0.1 M phosphate buffer (pH 6.5) instead of sample solution as blank sample solution. L-tyrosine (1500 U / mL) was used as a substrate by dissolving in 0.1 M sodium phosphate buffer (pH 6.5).

The inhibition rate of tyrosinase activity of each sample solution was calculated according to Equation 2 below and the experimental results are shown in Table 3 below.

% Inhibition of tyrosinase activity = 100- (control absorbance / control absorbance) x 100

Myeongdangsam Extract (㎍ / ㎖) Inhibition rate of tyrosinase activity (%) 5 25.4 10 33.7 20 41.3 50 57.1 100 63.0 200 76.9

As can be seen from the results of Table 3, it was confirmed that the extract of Myeongdangsam increased the tyrosinase activity inhibitory effect in a concentration-dependent manner.

Hereinafter, although the extract of Myeongdangsam prepared from Preparation Example 1 of the present invention was used in the formulation example, it is not limited thereto.

Formulation example  1. flexible lotion ( skin )

Formulation examples of the flexible lotion (skin) in the cosmetic comprising the extract of Myeongdangsam of the present invention is as follows:

ingredient Content (% by weight) Myeongdangsam Extract of Preparation Example 1 1.0 1,3-butylene glycol 5.2 Oleyl alcohol 1.5 ethanol 3.2 Polysorbate 20 3.2 Benzophenone-9 2.0 Carboxyl Vinyl Polymer 1.0 glycerin 3.5 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation example  2. Nutritional Cosmetics ( Milk Croissant )

Formulation examples of nutrient cosmetics (milk lotion) in the cosmetic comprising the extract of Myeongdangsam of the present invention is as follows:

ingredient Content (% by weight) Myeongdangsam Extract of Preparation Example 1 2.0 glycerin 5.1 Propylene glycol 4.2 Tocopheryl acetate 3.0 Liquid paraffin 4.6 Triethanolamine 1.0 Squalane 3.1 Macadamia Nut Oil 2.5 Polysorbate 60 1.6 Sorbitan sesquirrolate 1.6 Propylparaben 0.6 Carboxyl Vinyl Polymer 1.5 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation example  3. Nutrition Cream

An example of the formulation of the nourishing cream in the cosmetic comprising the extract of Myeongdangsam of the present invention is as follows:

ingredient Content (% by weight) Myeongdangsam Extract 3.0 Lipophilic monostearate 2.0 Cetearyl Alcohol 2.2 Stearic acid 1.5 Beeswax 1.0 Polysorbate 60 1.5 Sorbitan stearate 0.6 Cured Vegetable Oil 1.0 Squalane 3.0 Mineral oil 5.0 Trioctanoine 5.0 Dimethicone 1.0 Sodium magnesium silicate 0.1 glycerin 5.0 Betaine 3.0 Triethanolamine 1.0 Sodium hyaluronate 4.0 Preservative, fragrance, coloring a very small amount Distilled water Balance Sum 100

Formulation example  4. Massage  cream

An example of the formulation of the massage cream in the cosmetic containing the extract of Myeongdangsam of the present invention is as follows:

ingredient Content (% by weight) Myeongdangsam Extract of Preparation Example 1              0.5 glycerin 4.0 vaseline 3.5 Triethanolamine 0.5 Liquid paraffin 24.0 Squalane 3.0 Beeswax 2.1 Tocopheryl acetate 0.1 Polysorbate 60 2.4 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.3 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation example  5. Pack

Formulation examples of the pack in the cosmetic containing the extract of Myeongdangsam of the present invention is as follows:

ingredient Content (% by weight)  Myeongdangsam Extract of Preparation Example 1 1.0 Ethyl alcohol 3.0 EDTA-2Na 0.02 Propylene glycol 5.1 Glyceline 4.5 Cabopol 1.0 Polyoxide 0.1 antiseptic a very small amount incense a very small amount Purified water Balance system 100

Experimental Example  4: whitening effect measurement

30 females, aged 26-45, with dark skin color, were prepared using the nutritional cream of Formulation Example 3 containing Myeongdangsam extract and the nutritional cream of Comparative Example using 1,3-BG instead of Myeongdangsam extract of Formulation Example 3. The whitening effect of was measured. Twelve positions of the subject's arms were displayed by 1 cm in width and length, irradiated with ultraviolet rays B three times at a daily dose of 0.7 MED, and then induced pigmentation for 7 days, and then each cosmetic of Formulation Example 3 was applied. , The other one was used as a control. Cosmetics were applied twice a day for two months. The skin color (L value) after 2 months was measured using Minolta CR 300 as a measuring device, and the change in skin color was calculated using Equation 3 below, and the results are shown in Table 9 below.

Change in skin color (ΔL value) = (L value before cosmetic application)-(L value after 2 months)

Skin color gradient division Comparative example Formulation Example 3 ΔL value 1.28 5.81

As can be seen from the results of Table 9, the ΔL value of Formulation Example 3 containing Myeongdangsam extract was increased by about 4.5 times compared to the comparative example without the Myeongdangsam extract. It can be seen that the whitening effect of the cosmetic composition containing Myeongdangsam extract is very excellent.

Having described the specific part of the present invention in detail, it is apparent to those skilled in the art that such a specific technology is only a preferred embodiment, and the scope of the present invention is not limited thereto. Thus, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (5)

Changdangsam smyrnioides Wolff ) Cosmetic composition for skin whitening containing the extract as an active ingredient. The cosmetic composition for skin whitening according to claim 1, wherein the extract of Myeongdangsam is contained in an amount of 0.001-30.0 wt% based on the total weight of the cosmetic composition. The extract of claim 1, wherein the extract of Myeongdangsam is selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate and 1,3-butylene glycol. A cosmetic composition for skin whitening, which is extracted using a solvent extraction method. The composition of claim 1 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Cosmetic composition for skin whitening, characterized in that it has a formulation selected from the group. The cosmetic method according to any one of claims 1 to 4, wherein the cosmetic composition is applied to human skin.