KR101003204B1 - 약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제 - Google Patents

약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제 Download PDF

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KR101003204B1
KR101003204B1 KR1020080013487A KR20080013487A KR101003204B1 KR 101003204 B1 KR101003204 B1 KR 101003204B1 KR 1020080013487 A KR1020080013487 A KR 1020080013487A KR 20080013487 A KR20080013487 A KR 20080013487A KR 101003204 B1 KR101003204 B1 KR 101003204B1
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South Korea
Prior art keywords
drug
solid lipid
lipid nanoparticles
cacao butter
nanoparticles
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KR1020080013487A
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English (en)
Korean (ko)
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KR20090088126A (ko
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나건
진상우
이돈행
함기백
신현철
정재용
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메콕스큐어메드 주식회사
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Priority to KR1020080013487A priority Critical patent/KR101003204B1/ko
Priority to PCT/KR2009/000530 priority patent/WO2009102121A2/fr
Publication of KR20090088126A publication Critical patent/KR20090088126A/ko
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Publication of KR101003204B1 publication Critical patent/KR101003204B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020080013487A 2008-02-14 2008-02-14 약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제 KR101003204B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020080013487A KR101003204B1 (ko) 2008-02-14 2008-02-14 약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제
PCT/KR2009/000530 WO2009102121A2 (fr) 2008-02-14 2009-02-04 Nanoparticules lipidiques solides pour l'administration de médicaments, leur procédé de production, et préparation injectable comprenant lesdites nanoparticules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020080013487A KR101003204B1 (ko) 2008-02-14 2008-02-14 약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제

Publications (2)

Publication Number Publication Date
KR20090088126A KR20090088126A (ko) 2009-08-19
KR101003204B1 true KR101003204B1 (ko) 2010-12-21

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KR1020080013487A KR101003204B1 (ko) 2008-02-14 2008-02-14 약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제

Country Status (2)

Country Link
KR (1) KR101003204B1 (fr)
WO (1) WO2009102121A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230136070A (ko) 2022-03-17 2023-09-26 성균관대학교산학협력단 면역세포 표적형 나노입자 및 이의 용도
KR20240087583A (ko) 2022-12-09 2024-06-19 성균관대학교산학협력단 면역세포의 활성화 및 면역세포의 엔지니어링을 위한 지질 나노입자 및 이의 용도

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MY163995A (en) 2010-03-12 2017-11-15 Berg Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
ES2384060B1 (es) * 2010-03-24 2013-09-23 Lipotec S.A. Cápsulas de nanopartículas lipídicas.
KR101304597B1 (ko) * 2010-11-02 2013-09-12 한남대학교 산학협력단 멀티-코어 구조를 갖는 생체적합성 입자의 제조방법 및 이에 의해 제조된 멀티-코어 구조를 갖는 생체적합성 입자
CN102697765B (zh) * 2012-06-29 2013-08-21 海南灵康制药有限公司 盐酸雷尼替丁枸橼酸铋钾药物组合物固体脂质纳米粒制剂
JP5957610B2 (ja) * 2012-08-31 2016-07-27 チュンアン ユニバーシティー インダストリー アカデミック コアポレイション ファウンデイション 塞栓用のミクロスフェアの製造方法及び薬物含有ナノ輸送体が結合されたミクロスフェアの製造方法
CN103462906B (zh) * 2013-08-27 2015-06-10 青岛东辉医药科技发展有限公司 一种注射用多西他赛纳米粒及其制备方法
KR102507324B1 (ko) 2019-06-11 2023-03-08 메콕스큐어메드 주식회사 수소펌프저해제를 포함하는 리포좀 및 이의 제조방법
CN110464708A (zh) * 2019-07-12 2019-11-19 广州加原医药科技有限公司 一种螺旋藻纳米制剂及其制备方法
KR102681030B1 (ko) * 2021-08-02 2024-07-02 한국화학연구원 올리고뉴클레오타이드가 봉입된 나노입자, 이의 제조방법 및 이를 포함하는 약학적 제제
CN114099465B (zh) * 2021-11-11 2023-01-06 华南农业大学 一种消化道环境响应型纳米结构脂质载体及其制备和应用
KR102450812B1 (ko) * 2022-03-07 2022-10-06 (주)바이노텍 고형 지질 복합 나노 에토좀 및 이의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
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KR100425226B1 (ko) * 2001-07-03 2004-03-30 주식회사 팜트리 아세클로페낙을 함유하는 경제적인 경구용 제제의 조성 및제법
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
KR100479637B1 (ko) * 2002-02-01 2005-03-31 한국화학연구원 란소프라졸을 함유하는 경구제제 및 그의 제조방법

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230136070A (ko) 2022-03-17 2023-09-26 성균관대학교산학협력단 면역세포 표적형 나노입자 및 이의 용도
KR20240087583A (ko) 2022-12-09 2024-06-19 성균관대학교산학협력단 면역세포의 활성화 및 면역세포의 엔지니어링을 위한 지질 나노입자 및 이의 용도

Also Published As

Publication number Publication date
KR20090088126A (ko) 2009-08-19
WO2009102121A3 (fr) 2009-10-22
WO2009102121A2 (fr) 2009-08-20

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