KR101001646B1 - (ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체 - Google Patents

(ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체 Download PDF

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Publication number
KR101001646B1
KR101001646B1 KR1020080126478A KR20080126478A KR101001646B1 KR 101001646 B1 KR101001646 B1 KR 101001646B1 KR 1020080126478 A KR1020080126478 A KR 1020080126478A KR 20080126478 A KR20080126478 A KR 20080126478A KR 101001646 B1 KR101001646 B1 KR 101001646B1
Authority
KR
South Korea
Prior art keywords
lansoprazole
formula
triphenyl
ethanediol
mixed solvent
Prior art date
Application number
KR1020080126478A
Other languages
English (en)
Korean (ko)
Other versions
KR20100067886A (ko
Inventor
장선영
김태원
김성범
김병구
최창주
김철경
하태희
서귀현
이관순
Original Assignee
한미약품 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한미약품 주식회사 filed Critical 한미약품 주식회사
Priority to KR1020080126478A priority Critical patent/KR101001646B1/ko
Priority to PCT/KR2009/007389 priority patent/WO2010068049A2/fr
Publication of KR20100067886A publication Critical patent/KR20100067886A/ko
Application granted granted Critical
Publication of KR101001646B1 publication Critical patent/KR101001646B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020080126478A 2008-12-12 2008-12-12 (ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체 KR101001646B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020080126478A KR101001646B1 (ko) 2008-12-12 2008-12-12 (ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체
PCT/KR2009/007389 WO2010068049A2 (fr) 2008-12-12 2009-12-10 Procédé pour préparer du (r)-(+)-lansoprazole et intermédiaire utilisé dans celui-ci

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020080126478A KR101001646B1 (ko) 2008-12-12 2008-12-12 (ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체

Publications (2)

Publication Number Publication Date
KR20100067886A KR20100067886A (ko) 2010-06-22
KR101001646B1 true KR101001646B1 (ko) 2010-12-17

Family

ID=42243227

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020080126478A KR101001646B1 (ko) 2008-12-12 2008-12-12 (ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체

Country Status (2)

Country Link
KR (1) KR101001646B1 (fr)
WO (1) WO2010068049A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011098938A1 (fr) * 2010-02-11 2011-08-18 Orchid Chemicals And Pharmaceuticals Limited Nouveau solvate du dexlansoprazole
CN110873767B (zh) * 2018-09-04 2022-03-11 天津药物研究院有限公司 一种右兰索拉唑合成中间体及其有关物质的快速检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051867A1 (fr) 2001-12-18 2003-06-26 Astrazeneca Ab Procede de preparation d'enantiomeres enrichis au niveau optique au moyen d'une chromatographie a lit mobile simule
WO2007140608A1 (fr) 2006-06-09 2007-12-13 Apotex Pharmachem Inc. Procédé de préparation de l'ésoméprazole et de ses sels
US20080275245A1 (en) 2004-10-11 2008-11-06 Neela Praveen Kumar Processes for the Preparation of Substituted Sulfoxides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051867A1 (fr) 2001-12-18 2003-06-26 Astrazeneca Ab Procede de preparation d'enantiomeres enrichis au niveau optique au moyen d'une chromatographie a lit mobile simule
US20080275245A1 (en) 2004-10-11 2008-11-06 Neela Praveen Kumar Processes for the Preparation of Substituted Sulfoxides
WO2007140608A1 (fr) 2006-06-09 2007-12-13 Apotex Pharmachem Inc. Procédé de préparation de l'ésoméprazole et de ses sels

Also Published As

Publication number Publication date
WO2010068049A3 (fr) 2010-10-28
KR20100067886A (ko) 2010-06-22
WO2010068049A2 (fr) 2010-06-17

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