KR100993487B1 - 카랄루마 추출물의 제조방법 및 사용 - Google Patents
카랄루마 추출물의 제조방법 및 사용 Download PDFInfo
- Publication number
- KR100993487B1 KR100993487B1 KR1020077024499A KR20077024499A KR100993487B1 KR 100993487 B1 KR100993487 B1 KR 100993487B1 KR 1020077024499 A KR1020077024499 A KR 1020077024499A KR 20077024499 A KR20077024499 A KR 20077024499A KR 100993487 B1 KR100993487 B1 KR 100993487B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- caraluma
- extract
- solvent
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000284 extract Substances 0.000 title claims abstract description 178
- 238000000034 method Methods 0.000 title claims abstract description 132
- 230000008569 process Effects 0.000 title description 44
- 241000517186 Caralluma Species 0.000 title description 2
- 229930182470 glycoside Natural products 0.000 claims abstract description 135
- 238000000605 extraction Methods 0.000 claims abstract description 115
- 150000002338 glycosides Chemical class 0.000 claims abstract description 90
- 239000011347 resin Substances 0.000 claims abstract description 87
- 229920005989 resin Polymers 0.000 claims abstract description 87
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- 238000001035 drying Methods 0.000 claims abstract description 19
- 238000002360 preparation method Methods 0.000 claims abstract description 19
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 18
- 238000000227 grinding Methods 0.000 claims abstract description 15
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims description 114
- 241000196324 Embryophyta Species 0.000 claims description 80
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 76
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 54
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical group CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 53
- -1 pregnan glycoside Chemical class 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 30
- 238000004519 manufacturing process Methods 0.000 claims description 27
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- 238000001704 evaporation Methods 0.000 claims description 18
- 239000011877 solvent mixture Substances 0.000 claims description 18
- 230000008020 evaporation Effects 0.000 claims description 16
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 11
- 229930182490 saponin Natural products 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 238000011084 recovery Methods 0.000 claims description 9
- 238000005406 washing Methods 0.000 claims description 9
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 5
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 3
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- 239000007858 starting material Substances 0.000 description 7
- 241000588724 Escherichia coli Species 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
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- 229930182478 glucoside Natural products 0.000 description 4
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- 150000008131 glucosides Chemical class 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
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- 230000000144 pharmacologic effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
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- 230000003110 anti-inflammatory effect Effects 0.000 description 2
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- 238000006243 chemical reaction Methods 0.000 description 2
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- JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane group Chemical group [C@@H]12CC[C@H](CC)[C@@]1(C)CC[C@H]1[C@H]2CCC2CCCC[C@]12C JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
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- 208000006820 Arthralgia Diseases 0.000 description 1
- WXLJRYSLYQBMGF-RUFGMRSTSA-N CO[C@@H]1[C@@H](O)[C@H](O[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]4[C@@H]3CC[C@]3(C)[C@H](CC[C@]43O)C(C)=O)C2)O[C@H](C)[C@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O Chemical compound CO[C@@H]1[C@@H](O)[C@H](O[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]4[C@@H]3CC[C@]3(C)[C@H](CC[C@]43O)C(C)=O)C2)O[C@H](C)[C@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O WXLJRYSLYQBMGF-RUFGMRSTSA-N 0.000 description 1
- 241001504156 Caralluma adscendens Species 0.000 description 1
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- 241000617429 Clowesia russelliana Species 0.000 description 1
- 240000006560 Coccinia grandis Species 0.000 description 1
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- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 241000023320 Luma <angiosperm> Species 0.000 description 1
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- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
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- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
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- 208000016261 weight loss Diseases 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN451/MAS/2003 | 2003-06-04 | ||
| IN451CH2003 | 2003-06-04 | ||
| PCT/IN2004/000150 WO2004108148A1 (en) | 2003-06-04 | 2004-05-31 | Processes for making caralluma extracts and uses |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057023343A Division KR20060034229A (ko) | 2003-06-04 | 2004-05-31 | 카랄루마 추출물의 제조방법 및 사용 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20070114833A KR20070114833A (ko) | 2007-12-04 |
| KR100993487B1 true KR100993487B1 (ko) | 2010-11-10 |
Family
ID=36011983
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057023343A Ceased KR20060034229A (ko) | 2003-06-04 | 2004-05-31 | 카랄루마 추출물의 제조방법 및 사용 |
| KR1020077024499A Expired - Lifetime KR100993487B1 (ko) | 2003-06-04 | 2004-05-31 | 카랄루마 추출물의 제조방법 및 사용 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057023343A Ceased KR20060034229A (ko) | 2003-06-04 | 2004-05-31 | 카랄루마 추출물의 제조방법 및 사용 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7060308B2 (enExample) |
| EP (1) | EP1644013A1 (enExample) |
| JP (2) | JP5260873B2 (enExample) |
| KR (2) | KR20060034229A (enExample) |
| CN (1) | CN1798566B (enExample) |
| AU (2) | AU2004244850B2 (enExample) |
| BR (1) | BRPI0411400A (enExample) |
| CA (1) | CA2527702C (enExample) |
| CO (1) | CO5660269A2 (enExample) |
| NZ (2) | NZ543995A (enExample) |
| WO (1) | WO2004108148A1 (enExample) |
| ZA (1) | ZA200509780B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060083795A1 (en) * | 2004-10-19 | 2006-04-20 | Lima Shatkina | Meal replacement products having appetite suppressing qualities |
| KR101307999B1 (ko) * | 2004-12-01 | 2013-09-12 | 니폰 조키 세야쿠 가부시키가이샤 | 건조물 및 그 제조방법 |
| US20060159773A1 (en) * | 2005-01-20 | 2006-07-20 | Stephen Holt | Herbal compositions containing hoodia |
| WO2007022141A1 (en) * | 2005-08-17 | 2007-02-22 | Charles Tadlock | Delivery system for appetite suppressant |
| CN101505771A (zh) * | 2006-08-17 | 2009-08-12 | 荷兰联合利华有限公司 | 含有甾体糖苷的hoodia植物萃取物的制造方法 |
| WO2008107910A2 (en) * | 2007-03-05 | 2008-09-12 | Ramaswamy Rajendran | Use of caralluma extracts in the inhibition of adipogenesis and a method of inhibition for the same |
| ZA201000727B (en) * | 2009-01-30 | 2010-11-24 | Vishwas Sudhu Ghare | An improved process for the preparation of caralluma extract and a formulation prepared thereof |
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| US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
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| EP0931550B1 (en) * | 1998-01-26 | 2004-09-22 | National Research Development Corporation, a Government of India Undertaking | A process for the preparation of a spermicidal agent |
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- 2005-12-01 ZA ZA200509780A patent/ZA200509780B/en unknown
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2012
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Also Published As
| Publication number | Publication date |
|---|---|
| US7060308B2 (en) | 2006-06-13 |
| CN1798566B (zh) | 2014-03-12 |
| AU2004244850A1 (en) | 2004-12-16 |
| NZ543995A (en) | 2009-02-28 |
| NZ573614A (en) | 2011-02-25 |
| KR20060034229A (ko) | 2006-04-21 |
| JP2013067638A (ja) | 2013-04-18 |
| JP2006526615A (ja) | 2006-11-24 |
| CA2527702C (en) | 2016-03-08 |
| AU2004244850B2 (en) | 2009-01-08 |
| WO2004108148A1 (en) | 2004-12-16 |
| KR20070114833A (ko) | 2007-12-04 |
| AU2008255233B2 (en) | 2012-01-12 |
| CA2527702A1 (en) | 2004-12-16 |
| JP5260873B2 (ja) | 2013-08-14 |
| US7390516B2 (en) | 2008-06-24 |
| US20040247702A1 (en) | 2004-12-09 |
| BRPI0411400A (pt) | 2006-07-25 |
| ZA200509780B (en) | 2006-09-27 |
| EP1644013A1 (en) | 2006-04-12 |
| CN1798566A (zh) | 2006-07-05 |
| US20050163871A1 (en) | 2005-07-28 |
| AU2008255233A1 (en) | 2009-01-22 |
| AU2004244850A2 (en) | 2004-12-16 |
| CO5660269A2 (es) | 2006-07-31 |
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