KR100984010B1 - Compound for trichogenousness and preventing the depilation - Google Patents

Abstract

PURPOSE: A composition for preventing hair loss and promoting hair growth is provided to effectively promote hair growth and to use in soap or cream cosmetic product and spray. CONSTITUTION: A composition for preventing hair loss and promoting hair growth contains distilled water which is irradiated by far infrared ray, herb extracts, Schizophyllum commune mycelium-derived polysaccharide, methyl sulfonyl methane, and alginate as active ingredients. The distilled water is obtained by dissolving NaOH in purified water, adding tourmaline powder or magnetite stone, adding ferric chloride, maturing, adding hydrochloric acid and purified water, centrifuging and separating supernatant. The herb extracts contains 10-30 weight% of Teucrium veronicoides, 10-30 weight% of mung bean, 10-30 weight% of Ledebouriella seseloides, 10-30 weight% of Pleuropterus multiflorus, 5-20 weight% of Ampelopsis Radix, 5-20 weight% of Glycyrrhiza uralensis, and 5-20 weight% of Allium flistulosum.

Description

Compound for preventing hair loss and promoting hair growth {Compound for trichogenousness and preventing the depilation}

The present invention relates to a composition for preventing hair loss and promoting hair growth.

Hair naturally falls through a period of vigorous growth (activity phase), a period of slow growth (degeneration phase), and finally a period of no growth (pause).

The active period in which hair hair cells of the hair are visibly dividing may vary depending on age and health condition of the person, but it is generally about 3 to 5 years, and the degeneration period is about 1 month, and the resting period. The hair does not fall out quickly and remains in the scalp for a long time (about 2-3 months).

In the off-season, the dermal papilla contracts, the hair follicles gradually crumble, and the hair roots are pushed upwards and fall out together. At this point, the dermal papilla begins to be active, and new hair cells begin to form. The hair is ready to be born.

This describes the life of a strand of hair, and this repetition is repeated several times in a lifetime.

The period during which a period of activity, a period of rest, and a new period of activity begins, is called a hair cycle, and as it ages, the period of activity becomes shorter. In addition, the average number of natural hair loss per day is increasing, and 50 to 60 a day exceeds 200. This hair loss is never pathological. The person who wants to be bald does not have no hair at all, and there is short hair in all pores, but it looks like bald because it is only thin and short, and after this stage, it becomes a completely hairless hair. Slow grooming can be a lifespan for some time.

Recently, a lot of hair loss occurs in women as well as men.

As a cause of social factors, hair loss occurs due to environmental pollution and various stresses, and hair loss occurs, and hair loss due to hair follicle growth disorders such as poor circulation of blood to the scalp is caused by various causes. have.

Numerous products presented as conventional hair growth promoters are urgent to find the cause of hair loss, and are only myopic prescriptions such as hormonal suppression, and have found natural medicines that are good for various hair and scalp, and have made hair growth accelerators mainly composed of herbal extracts.

The skin is divided into epidermis, dermis and subcutaneous fat. Hair follicles are located between the epidermis and dermis, and the epidermis is divided into five layers (stratum corneum, transparent layer, granule layer, polar layer and basal layer).

No matter how good the herbal extract hair growth promoter is difficult to penetrate more than the granule layer and the polar layer to reach the hair follicles, the root of the hair, it takes a lot of time and effort to promote hair growth.

The tissue composition of our skin is made up of cells, and there is a problem with how the nutrients are quickly delivered to the hair follicle between the epidermis and the dermis through the cell membrane.

Thus, the present inventors have conducted research to solve these problems, the present invention by confirming that the effect of preventing hair loss and hair growth is greatly improved when using a combination of distilled water, herbal extracts, mushroom polysaccharides, natural organic sulfur and alginic acid radiated far infrared rays To complete.

Accordingly, an object of the present invention is to provide a composition for preventing hair loss and promoting hair growth, containing distilled water, herbal extract, mushroom polysaccharide, natural organic sulfur, and alginic acid in which far infrared rays are radiated.

The present invention is characterized by a composition for preventing hair loss and promoting hair growth, containing distilled water, herbal extracts, mushroom polysaccharides, natural organic sulfur and alginic acid as far active radiation as active ingredients.

The hair loss prevention and hair growth promoting composition according to the present invention has no side effects on the skin by using distilled water that emits far infrared rays, and various medicines by confirming the excellent hair growth, hair growth, and wool effects compared to existing hair growth promoters. It is expected to be used in a variety of applications in cosmetics.

Figure 1 is a photograph showing the result of using the composition of Example 1 three times a day for 9 to 15 days at intervals of 5 hours.
Figure 2 is a photograph showing the result of using the composition of Example 2 three times a day for 7 to 12 days at intervals of 5 hours.
3 shows the results of using the composition of Example 3 three times a day for 8 days at 5 hour intervals (upper), and the results of using the composition of Example 3 6 times a day for 2 days at 2 days (in middle), Example 3 It is a photograph showing the result (bottom) of using the composition of the eyebrow three times a day for 5 days at intervals of 5 hours.
Figure 4 is a photograph showing the results of using the composition of Example 4 in two groups (left and right) for 13 days at 5 hours intervals three times a day.

Hereinafter, the present invention will be described in detail.

The present invention relates to a composition for preventing hair loss and promoting hair growth, containing distilled water, herbal extracts, mushroom polysaccharides, natural organic sulfur, and alginic acid as far active ingredients.

The "distant infrared radiation distilled water" is dissolved in 50 to 150 parts by weight of sodium hydroxide in 1000 parts by weight of purified water, 50 to 200 parts by weight of magnetite ore tourmaline powder or tourmaline is added to about 1500 to 2000 rpm stirrer After stirring to a strong alkali, ferric chloride or ferric chloride 50 to 250 parts by weight, and stirred for at least 12 hours, and then neutralized to pH.7 to 7.5 by adding hydrochloric acid and purified water It refers to distilled water that emits far-infrared rays obtained by distilling the supernatant after distillation in a distillation after adding 20 to 30 parts by weight. This far-infrared distilled water contains far-infrared rays 366 (microns), and the water cluster width is narrowed to 55 Hz. In general, the far infrared wavelength ranges from 4 to 1000 (microns).

In fact, water does not exist as a single molecule (H₂O) but is composed of 4 molecules, 6 molecules, etc., forming a cluster group (cluster). Narrow water clusters (clusters) Narrow water can penetrate deep into the skin, and depending on what substances you add to it, you can get a lot of difference.

In various literatures, tap water is about 110 to 130 Hz, good water is about 100 Hz, and longevity is about 80 to 100 Hz.

Various plants are also known to grow well in narrow waters (clusters), and the body's moisture is about 62 to 65 Hz.

The tissue composition of human skin is composed of cells. Cells have passages through which water can permeate, ranging in size from 0.3 to 1.3 nm. Therefore, when the water cluster is large, it is not easy to be absorbed by the cells, and when the water of the cluster is narrow, deep penetration into the skin can be obtained to obtain a desired effect.

Therefore, in the present invention, by using distilled water in which far-infrared rays with a narrowed population (cluster) width are radiated, the penetrating deep into the skin together with the active ingredients was able to exert its effects significantly.

In addition, the "medicinal herb extract" is 10 to 30% by weight of mung beans 10-30% by weight, windproof 10-30% by weight, sewage 10-30% by weight, 5-20% by weight, almond 5-20% %, Licorice 5-20% by weight, leek root 5-20% by weight and leek root 5-20% by weight, and 10-40 parts by weight of the mixture is water, lower alcohols having 1 to 6 carbon atoms or mixtures thereof (preferably Refers to an extract obtained by adding to 100 parts by weight of 50-98% ethanol aqueous solution) and immersing for 6 to 15 days at room temperature (20 to 30 ° C.), followed by filtration.

In addition, the mushroom polysaccharide may be prepared by a conventional manufacturing method in the art, in the following examples, the mushroom polysaccharide was used by the method disclosed in the domestic patent registration No. 770016. It is known that the effect is excellent in burn and wound healing activity.

In addition, the natural organic sulfur means methyl sulfonyl methane (MSM), white odorless, non-toxic, used in cosmetics, health foods, etc., has an excellent effect on detoxification, sterilization, antibacterial, anti-inflammatory, analgesic.

In addition, alginic acid is a fibrous part of natural seaweeds, and is known for its excellent effect on hair nutrition and growth.

The active ingredient thus proved in the following examples that the hair loss prevention and hair growth promoting effect is excellent, accordingly, the composition for preventing hair loss and hair growth promoting containing the active ingredient of the present invention can be formulated into cosmetics and pharmaceuticals.

Hair loss prevention and hair growth promoting composition of the present invention comprises the active ingredient in an amount of 0.1 to 50% by weight based on the total weight of the composition. However, the composition as described above is not necessarily limited to this, and may vary according to the condition and progression of the patient.

The composition containing the active ingredient of the present invention is a skin external preparation for preventing hair loss and promoting hair growth, and is a composition for external application of a cream, gel, patch, ointment, warning agent, lotion, liquid, emulsion, powder or spray. It can be manufactured and used as, but is not limited thereto.

When the formulation of the present invention is a cream or a gel, animal fibers, plant fibers, waxes, paraffins, starches, trakant, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, and especially in the case of spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a liquid or emulsion, a solvent, solvating agent or emulsifying agent is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethyleneglycol or sorbitan.

The preferred dosage of the active ingredient of the present invention depends on the condition and weight of the patient, the extent of the disease, the form of the drug, the route and duration of administration, and may be appropriately selected by those skilled in the art. However, for the desired effect, the extract of the present invention is preferably administered at 0.0001 to 100 mg / kg, preferably at 0.001 to 10 mg / kg. Administration may be administered once a day or may be divided several times. The dosage does not limit the scope of the present invention in any aspect, but preferably it is very convenient to use as an external liquid, it is used on the site of hair loss about 2-3 times a day, and lightly pat the scalp The effect can be doubled, as the penalty helps smoothly.

In addition, it can be used in various ways to prevent hair loss and hair growth promoting cosmetics containing the active ingredient of the present invention. Cosmetics that can be formulated with the compositions of the present invention include, for example, tonics, conditioners, essences, lotions, shampoos, rinses, treatments, creams, waxes, aerosols, packs, soaps, hair dryers, hair preservatives, hair colorants , Wave, bleach, gel, hair glaze, mousse or spray.

The cosmetic of the present invention may be any compound as long as it can be formulated into a cosmetic, but natural preservatives, thickeners and polymers are preferred, and methyl parabens may be mentioned as preservatives, and hydroethyl cellulose may be mentioned as thickeners. The high molecular material may include amino acids, silicic acid, tocopherol acetate, nicotinic acid amide, etc. constituting a polypeptide (polypeptide: two or more amino acid compounds containing -CO HN-).

Other compounding ingredients that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, Alcohol, a pigment, a fragrance | flavor, a blood circulation promoter, a cooling agent, a restriction | limiting agent, purified water, etc. are mentioned.

Moreover, the compounding component which may be added other than this is not limited to this, Moreover, Although all said components can be mix | blended within the range which does not impair the objective and effect of this invention, Preferably it is 0.01-5 weight% with respect to a total weight, More preferably, it is mix | blended in 0.01 to 3 weight%.

Hereinafter, the present invention will be described in detail based on the following examples, but the present invention is not limited thereto.

Reference Example  1: Preparation of Distilled Water with Far Infrared Rays Radiated

After dissolving 50 g of 98% sodium hydroxide in 1000 g of distilled water, 50 g of tourmaline powder was added thereto, stirred at 1700 rpm, and 60 g of ferric chloride (37 Beaume) was added thereto to prepare a strong alkali solution. At this time, the time point at which the blue reactant was completely changed to the brown reactant was used as the end point of the reaction.

The strong alkaline solution was left to age for 12 hours, neutralized with hydrochloric acid (pH 7 to 7.5), and then 1000 g of distilled water was added thereto, followed by stirring. After 24 hours of standing, the supernatant was separated and 18000 g of a clear and transparent supernatant were distilled in a distiller to obtain about 1620 g of distilled water with far infrared radiation.

Reference Example  2: Preparation of herbal extract

15% by weight of quack, 20% by weight of mung bean, 20% by weight of windproof, 20% by weight of sewage, 10% by weight of baekryeom, 10% by weight of algae, 10% by weight of licorice, 10% by weight of leek root and 10% by weight of leek root, 100 parts by weight of an aqueous 98% ethanol solution was added to 80 parts by weight of the mixture, followed by immersion for 10 days at room temperature (25 ° C.), followed by filtration through a filter to obtain 66 g of herbal extract.

Example  1 to 4

Next, using the composition of Table 1, a total of 100% by weight of the external liquid formulation was prepared by a conventional method for preparing external liquid formulations.

Classification (wt%) Example 1 Example 2 Example 3 Example 4 Active ingredient Distilled water with far infrared radiation ¹⁾ Quantity Quantity Quantity Quantity Herbal extract ²⁾ 3 5 4 3.5 Mushroom Polysaccharide ³⁾ 2 2 One 2.5 Natural organic sulfur ⁴⁾ One One 1.5 2.5 Alginic acid One 0.5 0.5 0.7 carrier Preservative ⁵⁾ 0.2 0.3 0.2 0.25 Food thickeners ⁶⁾ One 0.5 0.5 0.7 Amino acid ⁷⁾ 0.5 0.7 0.6 0.8 Nicotinic acid amide 0.1 0.2 0.3 0.4 Tocophenol Acetate 0.5 0.1 0.3 - total 100 100 100 100 1) Distilled water of Preparation Example 1
2) herbal extract of Preparation Example 2
3) Polysaccharide from Skirt Mushroom Mycelium, MML Biotech
4) MSM (Methyl Sulfonyl Methane is an abbreviation of natural organic sulfur compound called Methyl Sulfonyl Methane. It is used in cosmetics and health foods as a colorless, odorless and nontoxic product.)
5) methylparaben
6) Hydroethyl Cellulose (HEC)
7) Sodium L-Glucarbonate, Sodium Ribonucleotide, Sodium L-aspartate

Test Example  One

Clinical trials of the external liquid formulations of Examples 1 to 4 were carried out as follows.

Each composition was sprayed on the scalp (detailed in the experimental procedure) for 7 to 15 days at 5 hours intervals three times a day to confirm hair growth and hair loss prevention effects.

In FIG. 1, the result of using the composition of Example 1 for 10 days (upper), the result of using the composition of Example 1 for 9 days (in), and the result of using the composition of Example 1 for 15 days (lower), all of the hair loss state I could see that most of them are filled.

In addition, in FIG. 2, the result of using the composition of Example 2 for 7 days (upper), the result of using the composition of Example 2 for 12 days (in), and the result of using the composition of Example 2 for 12 days (lower), all The state was filled with a lot of people could see.

In addition, in FIG. 3, the result of using the composition of Example 3 for 8 days (upper), and the result of using the composition of Example 3 for 2 days at 2 hour intervals 6 times a day (middle), the composition of Example 3 to the eyebrows As a result of using it for 7 days (bottom), it was confirmed that the state of all the hair caps filled most.

In addition, Figure 4 shows the results of using the composition of Example 4 for 13 days to the other left and right experiments, all confirmed the hair growth promoting effect.

As mentioned above, the composition of this invention was shown notably in the early stage of the hair loss prevention and hair growth promoting effect.

Formulation example  One : Liquid  Produce

Using the active ingredient composition of Example 1 to prepare a liquid according to the conventional manufacturing method in the following composition.

[Composition: 100 g total]

5 g of active ingredients, 7 g of ethyl 3- (N-butylacetamido) propionate, 6 g of octylmethoxycinnamate, 3 g of oxybenzone, 1 g of Tween80, 180 mg of methylparaben, 20 mg of propylparaben, 1 g of sodium pyrosulphite, 6 g of concentrated glycerin, 20 g of ethanol, 1 g of antifoam, proper amount of lemon flavor, remaining amount of purified water

Formulation example  2: Preparation of Ointment

Using the active ingredient composition of Example 1 was prepared an ointment with the following composition.

[Furtherance]

Active ingredient 1.0 parts by weight, beeswax 10 parts by weight, polysorbate-60 5.0 parts by weight, sebum-60 cured castor oil 2.0 parts by weight, sorbitan sesquioleate 0.5 parts by weight, petrolatum 5.0 parts by weight, liquid paraffin 10.0 parts by weight .

Formulation example  3: cream manufacturer

Active ingredient composition of Example 1 ............ 1.00 (%)

Polyethylene Glycol Monostearate ......... 2.00

Self-emulsifying glycerine monostearate ......... 5.00

Cetyl Alcohol ... 4.00

Squalene ......................... 6.00

Glyceryl tri2-ethylhexanoate ... 6.00

Sphingose Glucose Lipid ............................ 1.00

1.3-Butylene Glycol ... 7.00

The total amount of purified water was adjusted to 100%, and a cream was prepared at the above compounding ratio.

None

Claims (6)

Sodium hydroxide was dissolved in purified water, magnetized ore or tourmaline powder was added and stirred to alkalinize. Aged with iron chloride, neutralized with hydrochloric acid, and purified water was added to separate supernatant after 24 hours. Distilled water;
Kwak Hyang 10-30 wt% Mung bean 10-30 wt%, Windproof 10-30 wt%, Sewage 10-30 wt%, Baiyun 5-20 wt%, Almond 5-20 wt%, Licorice 5-20 wt%, Leek root Herbal extract obtained by extracting 5-20% by weight and 5-20% by weight of green onion root;
Polysaccharide derived from S. mushroom mycelium;
Methyl sulfonyl methane; And
Alginic acid
Hair loss prevention and hair growth promoting composition characterized in that it contains as an active ingredient. The method according to claim 1, wherein 70 to 94% by weight of far-infrared radiation, 3 to 10% by weight of herbal extract, 1 to 7% by weight of polysaccharide-derived mycelium mycelium, 1 to 10% by weight of methyl sulfonyl methane And alginate 0.1 to 5% by weight as an active ingredient hair loss prevention and hair growth promoting composition, characterized in that. delete delete A skin external preparation containing the composition of claim 1 or 2. Cosmetic composition characterized by containing the composition of Claim 1 or 2.

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