KR100956907B1 - 아미노펩티다아제 - Google Patents

아미노펩티다아제 Download PDF

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Publication number
KR100956907B1
KR100956907B1 KR1020087030860A KR20087030860A KR100956907B1 KR 100956907 B1 KR100956907 B1 KR 100956907B1 KR 1020087030860 A KR1020087030860 A KR 1020087030860A KR 20087030860 A KR20087030860 A KR 20087030860A KR 100956907 B1 KR100956907 B1 KR 100956907B1
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South Korea
Prior art keywords
polypeptide
aminopeptidase
gene
sequence
human
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KR1020087030860A
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English (en)
Korean (ko)
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KR20090018142A (ko
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존 씨. 졸리
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제넨테크, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Detergent Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020087030860A 2001-09-13 2002-09-12 아미노펩티다아제 Expired - Lifetime KR100956907B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32235001P 2001-09-13 2001-09-13
US60/322,350 2001-09-13

Related Parent Applications (1)

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KR1020047003708A Division KR100954641B1 (ko) 2001-09-13 2002-09-12 아미노펩티다아제

Publications (2)

Publication Number Publication Date
KR20090018142A KR20090018142A (ko) 2009-02-19
KR100956907B1 true KR100956907B1 (ko) 2010-05-11

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ID=23254494

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KR1020047003708A Expired - Lifetime KR100954641B1 (ko) 2001-09-13 2002-09-12 아미노펩티다아제
KR1020087030860A Expired - Lifetime KR100956907B1 (ko) 2001-09-13 2002-09-12 아미노펩티다아제

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KR1020047003708A Expired - Lifetime KR100954641B1 (ko) 2001-09-13 2002-09-12 아미노펩티다아제

Country Status (21)

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US (3) US6921659B2 (enExample)
EP (1) EP1432793B1 (enExample)
JP (2) JP4831932B2 (enExample)
KR (2) KR100954641B1 (enExample)
CN (1) CN100552023C (enExample)
AT (1) ATE440134T1 (enExample)
AU (1) AU2002326884B2 (enExample)
BR (1) BR0212886A (enExample)
CA (1) CA2460309C (enExample)
CY (1) CY1109903T1 (enExample)
DE (1) DE60233417D1 (enExample)
DK (1) DK1432793T3 (enExample)
ES (1) ES2329880T3 (enExample)
HU (3) HU225346B1 (enExample)
IL (2) IL160658A0 (enExample)
MX (1) MXPA04002326A (enExample)
NZ (2) NZ531516A (enExample)
PL (1) PL206286B1 (enExample)
PT (1) PT1432793E (enExample)
WO (1) WO2003023030A2 (enExample)
ZA (1) ZA200401752B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2460309C (en) 2001-09-13 2012-07-10 Genentech, Inc. Aminopeptidase
SI1733037T1 (sl) 2004-03-11 2015-02-27 Genentech, Inc. Postopek za izdelavo polipeptidov
EP2376619A4 (en) 2008-12-15 2012-07-04 Greenlight Biosciences Inc METHODS FOR CONTROLLING FLOWS IN METABOLIC PATHWAYS
WO2010074760A1 (en) * 2008-12-22 2010-07-01 Greenlight Biosciences Compositions and methods for the production of a compound
US8956833B2 (en) 2010-05-07 2015-02-17 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
EP2611922A1 (en) 2010-08-31 2013-07-10 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
SG2014014377A (en) 2011-09-09 2014-05-29 Greenlight Biosciences Inc Cell-free preparation of carbapenems
CA2919383A1 (en) 2013-08-05 2015-02-12 Greenlight Biosciences, Inc. Engineered proteins with a protease cleavage site
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
CR20170485A (es) 2015-03-30 2018-02-05 Greenlight Biosciences Inc Producción de ácido ribonucleico libre de células
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10954541B2 (en) 2016-04-06 2021-03-23 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN106967658B (zh) * 2017-02-23 2020-09-15 郑州大学 一种提高Fab抗体表达量的方法
SG11202003192UA (en) 2017-10-11 2020-05-28 Greenlight Biosciences Inc Methods and compositions for nucleoside triphosphate and ribonucleic acid production
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU591464B2 (en) * 1984-08-16 1989-12-07 Savient Pharmaceuticals, Inc. Method of removing n-terminal amino acid residues using aeromonas aminopeptidases
WO1986007380A1 (fr) * 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Procede de preparation de polypeptides
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
US4946783A (en) * 1987-01-30 1990-08-07 President And Fellows Of Harvard College Periplasmic protease mutants of Escherichia coli
EP0300035B1 (en) 1987-01-30 1995-05-10 The President And Fellows Of Harvard College Periplasmic protease mutants of escherichia coli
JPH01181796A (ja) * 1988-01-14 1989-07-19 Ajinomoto Co Inc 組換えｄｎａ法を用いたポリペプチドの製造法
JP2844870B2 (ja) * 1989-07-21 1999-01-13 味の素株式会社 組み替えｄｎａ法によるポリペプチドの製造法
US5508192A (en) * 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US5304472A (en) * 1992-11-20 1994-04-19 Genentech, Inc. Method of controlling polypeptide production in bacterial cells
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
US6127144A (en) * 1993-12-23 2000-10-03 Cangene Corporation Method for expression of proteins in bacterial host cells
US5789199A (en) * 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5639635A (en) * 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
KR100369839B1 (ko) * 1997-02-28 2003-06-12 주식회사 엘지생명과학 바실러스리케니포미스균주에서유래한아미노펩티다제,그의제조방법및이를이용한천연형단백질의제조방법
EP1137763A1 (en) * 1998-12-07 2001-10-04 Novozymes A/S Glucoamylases with n-terminal extensions
KR20020011399A (ko) * 1999-04-30 2002-02-08 파마시아 코포레이션 에어로모나스 아미노펩티다제로 ν-말단 알라닌 잔기를폴리펩티드로부터 제거하는 방법
KR100400638B1 (ko) 2000-12-06 2003-10-08 주식회사 엘지생명과학 재조합 인간 성장호르몬 유사체의 분리방법
CA2460309C (en) 2001-09-13 2012-07-10 Genentech, Inc. Aminopeptidase

Non-Patent Citations (1)

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Title
Science,1997, vol 277, pp1453-1462.

Also Published As

Publication number Publication date
WO2003023030A2 (en) 2003-03-20
BR0212886A (pt) 2004-10-13
ES2329880T3 (es) 2009-12-02
US7229787B2 (en) 2007-06-12
ATE440134T1 (de) 2009-09-15
HU0600310D0 (en) 2006-06-28
JP2005502359A (ja) 2005-01-27
US20080160572A1 (en) 2008-07-03
KR100954641B1 (ko) 2010-04-27
CA2460309C (en) 2012-07-10
AU2002326884B2 (en) 2007-10-18
HK1062695A1 (en) 2004-11-19
CY1109903T1 (el) 2014-09-10
JP5372061B2 (ja) 2013-12-18
HUP0401869A2 (hu) 2004-12-28
NZ531516A (en) 2006-03-31
US20060019341A1 (en) 2006-01-26
CN100552023C (zh) 2009-10-21
WO2003023030A3 (en) 2003-07-10
EP1432793B1 (en) 2009-08-19
HUP0401869A3 (en) 2005-06-28
CA2460309A1 (en) 2003-03-20
NZ544964A (en) 2007-08-31
US7632658B2 (en) 2009-12-15
EP1432793A4 (en) 2006-05-24
JP2011177189A (ja) 2011-09-15
MXPA04002326A (es) 2004-06-29
PL368463A1 (en) 2005-04-04
DK1432793T3 (da) 2009-12-07
EP1432793A2 (en) 2004-06-30
HU225346B1 (en) 2006-10-28
HU225243B1 (en) 2006-08-28
ZA200401752B (en) 2005-05-25
HU225430B1 (en) 2006-11-28
HU0600309D0 (en) 2006-06-28
CN1555412A (zh) 2004-12-15
KR20090018142A (ko) 2009-02-19
KR20040041611A (ko) 2004-05-17
US20030124664A1 (en) 2003-07-03
PT1432793E (pt) 2009-11-24
IL160658A0 (en) 2004-08-31
DE60233417D1 (en) 2009-10-01
US6921659B2 (en) 2005-07-26
PL206286B1 (pl) 2010-07-30
JP4831932B2 (ja) 2011-12-07
IL160658A (en) 2009-05-04

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