KR100930606B1 - 폴리알킬렌 글리콜을 포함하는 칼시토닌 약물-올리고머접합체의 혼합물, 그의 용도 및 그의 제조방법 - Google Patents

폴리알킬렌 글리콜을 포함하는 칼시토닌 약물-올리고머접합체의 혼합물, 그의 용도 및 그의 제조방법 Download PDF

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KR100930606B1
KR100930606B1 KR1020037015912A KR20037015912A KR100930606B1 KR 100930606 B1 KR100930606 B1 KR 100930606B1 KR 1020037015912 A KR1020037015912 A KR 1020037015912A KR 20037015912 A KR20037015912 A KR 20037015912A KR 100930606 B1 KR100930606 B1 KR 100930606B1
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mixture
calcitonin
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moiety
oligomer
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KR1020037015912A
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Korean (ko)
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KR20040004694A (ko
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익크유리브녹키리엔.
프라이스크리스토퍼에이치.
안사리아슬람엠.
오덴보우에이미엘.
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바이오콘 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
KR1020037015912A 2001-06-04 2002-06-04 폴리알킬렌 글리콜을 포함하는 칼시토닌 약물-올리고머접합체의 혼합물, 그의 용도 및 그의 제조방법 KR100930606B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/873,777 2001-06-04
US09/873,777 US6713452B2 (en) 2001-06-04 2001-06-04 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
PCT/US2002/017575 WO2002098451A1 (en) 2001-06-04 2002-06-04 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

Publications (2)

Publication Number Publication Date
KR20040004694A KR20040004694A (ko) 2004-01-13
KR100930606B1 true KR100930606B1 (ko) 2009-12-09

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US (2) US6713452B2 (US06713452-20040330-C00013.png)
EP (1) EP1404360B1 (US06713452-20040330-C00013.png)
JP (1) JP4272510B2 (US06713452-20040330-C00013.png)
KR (1) KR100930606B1 (US06713452-20040330-C00013.png)
CN (1) CN100515492C (US06713452-20040330-C00013.png)
AT (1) ATE454160T1 (US06713452-20040330-C00013.png)
CA (1) CA2449686A1 (US06713452-20040330-C00013.png)
CY (1) CY1109932T1 (US06713452-20040330-C00013.png)
DE (1) DE60235010D1 (US06713452-20040330-C00013.png)
DK (1) DK1404360T3 (US06713452-20040330-C00013.png)
ES (1) ES2339224T3 (US06713452-20040330-C00013.png)
MX (1) MXPA03011283A (US06713452-20040330-C00013.png)
WO (1) WO2002098451A1 (US06713452-20040330-C00013.png)

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CA2449686A1 (en) 2002-12-12
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