KR100912912B1 - Herbal composition for relieving and treating primary dysmenorrhea - Google Patents

Abstract

The present invention relates to a herbal composition for relieving and treating primary dysmenorrhea, and includes a total of 14 kinds including woowoo, gyeji, uiyiin, creation, hyangbuja, dermis, hyssop, quince, betel nut, vigor, fennel, scented, licorice and rich By containing the herbal medicine, it is possible to treat the symptoms of menstrual pain such as belly pain, back pain, swelling, and headache, which appear in most menstrual pain patients.

Menstrual pain, herbal composition, herbal medicine, herbal medicine, ear cow

Description

Herbal composition for relieving and treating primary dysmenorrhea

1 is a graph showing the change in menstrual pain according to the period of administration of the normal body type taking the herbal composition of the present invention.

Figure 2 is a graph showing the change in menstrual pain in accordance with the duration of the obese body type taking the herbal composition of the present invention.

The present invention relates to a herbal composition for alleviating and treating primary dysmenorrhea, and more particularly, to a herbal composition for alleviating and treating dysmenorrhea occurring before or during menstruation of a primary dysmenorrhea patient.

Menstrual pain is the most common gynecological disease experienced by about 50% of women after puberty, of which about 10 to 15% of women experience pain that is difficult for daily life for one to three days each month. As a result, menstrual cramps are a major cause for young women to leave work or school and cause loss of working time or learning disabilities.

Menstrual pain is classified into primary (primary) dysmenorrhea and secondary (secondary) dysmenorrhea depending on the cause. Primary dysmenorrhea is a constitution that occurs without any special lesions in the pelvis or uterus. As "prostaglandin (prostaglandin), developing hormone is secreted over-represented is enhancing the uterine contractions that, TCM side is recognized as" tweaked i.e. barrel (不通則痛), that the high and the pressure pain occurs because the work. Usually, the pain begins several hours before or shortly after menstruation and lasts for two to three days. It feels like pain relief in the upper bladder, and pain can spread to lower back and sacral pain and thighs, and may be accompanied by diarrhea with nausea and vomiting. On the other hand, secondary dysmenorrhea is a pain caused by the development of a special lesion in the uterus or surrounding organs. The causes of the lesion include uterine myoma, uterine adenoma, endometriosis, ovarian cyst, pelvic inflammation, pelvic adhesion, intrauterine contraceptive device, tumor, etc. There is this. The pain manifests itself as the lesion develops in the last few years after menarche, which is different from primary dysmenorrhea in that it begins to appear one to two weeks before the start of menstruation and lasts for several days after the end of menstruation.

In general, the uterus has a different intensity of uterine contractions depending on the menstrual cycle. In normal people without dysmenorrhea, excessive uterine contractions occur during menstruation, so intrauterine pressure may increase to 100 mmHg or more. In luteal phase, intrauterine pressure increases slightly to 60-90 mmHg, and uterine contractions occur before menstruation a few days before menstruation. Non-ovulation cycles, ie, lack of progesterone, show only uterine contractions similar to the proliferative phase. However, patients with primary dysmenorrhea have a longer duration of uterine contraction than normal people, higher intrauterine pressure during the absence of uterine contraction, and intrauterine pressure may increase to 200-300 mmHg during contraction. This excessive uterine contraction reduces the blood supply to the uterus, resulting in anemia in the uterus, which is believed to result in primary dysmenorrhea.

Relief and treatment of primary dysmenorrhea, which accounts for the majority of dysmenorrhea, is a symptomatic treatment of warming the lower abdomen, avoiding cold foods, exercising lightly, taking a warm shower to help the body's blood circulation, and administering prostaglandin inhibitors. Estrogen therapy, progesterone therapy, testrosterone therapy, uterine contraction inhibitors, and the like are widely known. The most common of these is the treatment of taking analgesics (aspirin is typical) that interfere with the synthesis of prostaglandins, but those who are allergic to aspirin drugs or have gastric ulcers cannot use them, and they are too much for painkillers. Dependence or long-term use is undesirable because it can have side effects.

On the other hand, in oriental medicine, Dangguisu (當歸 鬚 散), Mantonghwan, Woltonghwan, etc. have been used in Samultang for the treatment of menstrual pain. There are various researches on another treatment method for menstrual pain using herbal medicine. Korean Patent Publication No. 10-2005-4950 relates to a composition for preventing and treating menstrual cramps and menstrual impurities containing complex herbal medicines. Shiho, safflower and omae complex extracts are used.

It is not limited to the method of using the previously known complex herbal medicines, and by mixing various herbal medicines properly, the duration of uterine contraction can be reduced, the intrauterine pressure during uterine contraction and the intrauterine pressure during contraction can be alleviated. And it is expected to be able to manufacture a herbal composition showing a more excellent effect on the treatment.

The present inventors have conducted research on various herbal medicines that are used as herbal medicine, and as a result, the herbal composition of the present invention including a total of 14 kinds of herbal medicines, including ear cows, which have not been used for prescription menstrual pain until now, can be used. The present invention has been found to have an excellent effect on the alleviation and treatment of primary dysmenorrhea.

An object of the present invention is to provide a herbal composition that can alleviate and treat primary dysmenorrhea.

In order to achieve the above object, the herbal composition for relieving and treating primary dysmenorrhea in accordance with the present invention is 10 to 12% by weight, 10 to 12% by weight, 7 to 9% by weight, 7 to 9% by weight, hyangbuja 5 to 7 based on the total weight of the composition 5% to 5% by weight, dermis 5 to 7% by weight, 5 to 6% by weight of quince, 5 to 7% by weight of quince, 5 to 7% by weight of betel nuts, 5 to 7% by weight of fennel, 5 to 7% by weight of fennel %, Licorice 5 to 7% by weight, rich 3 to 4% by weight and the balance is made to include the ear cow.

Hereinafter, the present invention will be described in more detail.

Herbal compositions for treating primary dysmenorrhea in accordance with the present invention include: Ramulus Euonymi, Ramulus Cinnamomi, Semen Coicis, Rhizoma Atractylodis japonicae, Hyangbuja (附) Rhizoma Cyperi, Cortex Fraxini, Radix Achyranthis Bidentatae, Fructus Chaenomelis, Semen Arecae, Rhizoma Seu Radix Notopterygh, Fructus Foeniculi, Mox (Radix Saussurea Seu Inulae), Licorice (Radix Glycyrrhizae) and Rich (Radix Aconiti Lateralis Preparata). The present invention was used as a representative medicine 'purewoowoo' which is not used anywhere in the past literature and 70 kinds of prescription for treating menstrual pain, and 'uiyiin' that removes and returns the dampness causing the discomfort. And 'creation', and the most characteristic is that the 'active' that only goes to Shihojeonghyangtang (柴胡 丁香 湯) of the prescription of menstrual pain is included, and the primary menstrual pain treatment effect is also excellent.

Among these components, Ramulus Euonymi treats symptoms such as menstrual disorders, bruises, postpartum abdominal pain, etc., and pharmacological actions include cardiac abnormalities, sedation, blood pressure lowering, hypoglycemic action, increased coronary blood flow, Intestinal contraction has been reported. In recent years, clinical applications have been applied to the treatment of liver and cervical cancer.

Ramulus Cinnamomi is the main ingredient of cinnamon aldehyde (cinnamon aldehyde about 85%) to control sweating on the surface of the skin and has analgesic effects such as menstrual pain, menstrual abnormalities, cold wind caused by a lot of cold wind, cold sweat, etc. Treat the condition Pharmacological action has been reported to inhibit the development of E. coli, Bacillus subtilis, Staphylococcus aureus, Pneumococcal pneumoniae, inhibits pandemic flu virus, and diuretic effect.

Semen Coicis is rich in proteins such as leucine and tyrosine and less glutamin than other grains. It is used to treat the symptoms of diarrhea, diarrhea, and loss of appetite due to species, indigestion and indigestion. It is also used for quadriplegia, pain, flexing and muscle aches, fever, drainage, appendicitis. Pharmacological action has been reported to be anti-cancer, skeletal muscle contraction suppression, intestinal uterus suppression, soothing, analgesic and antipyretic effect.

Rhizoma Atractylodis japonicae includes, as its main component, atacticulol (Atractylol; C ₁₅ H ₂₄ O), attractyllon (C ₁₄ H ₁₈ O), vitamin A, vitamin D and the like. It strengthens digestive function, filters out abnormal body fluids and improves eyesight to treat abdominal distension, diarrhea, edema, each one, and dark eyes at night.

Rhizoma Cyperi, the main ingredient, contains Cyperene (about 37%) and Cyperol (about 48%), regulates menstruation, treats pulmonary tuberculosis, intercostal pain, dysmenorrhea, etc. .

Cortex Fraxini contains volatile essential oils, glycosides (Hesperidin, C ₂₈ H ₃₄ O ₁₅ ), citric acid, etc. Treat nausea, indigestion, flatulence, drowsiness, and stool diarrhea. Pharmacological action has been reported that essential oils have digestive stimulation, digestive stimulation, expectorant, anti-ulcer, antigastric secretion, cardiac, blood pressure increase, antiallergic, bile secretion, uterine smooth muscle suppression, antibacterial action.

Radix Achyranthis Bidentatae contains saponin, potassium, mucus, etc. It has blood circulation and joint nutrition to treat menstrual abnormalities, postpartum abdominal pain, joint pain and hemorrhage. As pharmacological action, uterine excitement, cholesterol lowering action, diuretic action, hypoglycemic action, liver function improvement action, etc. have been reported.

Chinese quince Fructus Chaenomelis contains citric acid, vitamin C, etc., and has quadriplegia pain, muscle flexion, lower extremity cramps, muscle stiffness, and sore throat. Used for As pharmacological actions, proteomic arthritis, edema suppression, ascites cancer suppression, intervertebral pharyngeal alleviation and the like have been reported.

Semen Arecae contains tannins and important alkaloids such as Arecaidine, Arecoline, Guvacine, Guavacoline, etc., used for tapeworms, diarrhea, skin diseases, headaches, etc. do.

Rhizoma Seu Radix Notopterygh has strong divergence and is used for external headache, chills and fever, joint pain, muscle spasms, scapula pain, guanhwasa, skin ulcers and swelling, early chills, fever and pain. . Pharmacological actions have been reported for antipyretic, analgesic, skin fungal inhibition, cardiac muscle blood flow.

Fructus Foeniculi contains 3-8% of essential oils and includes anethole (C ₁₀ H ₁₂ O, 50-60%), fatty oil, and the like as its main components. It warms the body, suppresses pain and strengthens the digestive system, so it is useful for gynecological diseases and indigestion.

Mokhyang (木香) Radix Saussurea Seu Inulae is used for abdominal pain, flat stomach, vomiting and diarrhea caused by cold abdomen. Used for Pharmacological action to release bronchial and small intestine spasms, blood pressure lowering action, antibacterial action has been reported.

Licorice (Radix Glycyrrhizae) contains Glycrichine (C ₄₂ H ₆₆ O ₁₈ ), Other Liquirtin (C ₂₁ H ₂₂ O ₉ ), Mannit, Asparagine, etc. Harmonize the toxicity of all drugs to make the drug appear well, to control the heat and morale of the book and all blood vessels to communicate well and to strengthen the muscles and bones. Jinhae, expectorant, muscle relaxation, diuretic, anti-inflammatory action and suppresses peptic ulcer. Pharmacological action has been reported detoxification, hepatitis, urticaria, dermatitis, eczema.

Radix Aconiti Lateralis Preparata (Acicotine) contains aconitine (C ₂₃ H ₄ NO ₁₁ ) and varies in amount and quality depending on the size and origin of roots. Kidney swells and has a cardiovascular effect due to various chronic diseases, weakness, systemic and limb joint paralysis, cold feeling, chronic ulcers, erosion, diarrhea, etc. are used. Pharmacological actions include cardiac muscle contraction, blood pressure rise, anti-inflammatory, analgesic, anti-cold action, immunopotentiation, pituitary and adrenal cortex excitability, and hypoglycemic action.

The herbal composition of the present invention is 10 to 15% by weight, 10 to 15% by weight, 7 to 10% by weight, 5 to 7% by weight, 5 to 7% by weight, 5 to 7% by weight of dermis, 5 to 5% by weight, based on the total weight of the composition. 7 wt%, quince 5-7 wt%, betel 5-7 wt%, active 5-7 wt%, fennel 5-7 wt%, cedar 5-7 wt%, licorice 5-7 wt%, rich 3-5 And by weight percent and remainder. All of these components mean in the form of conventional dried medicinal herbs used in the manufacture of Chinese medicine. When each component is out of the upper and lower limits, the effect of improving excessive uterine contraction in primary dysmenorrhea patients is not so large that the menstrual pain relief and treatment effect is weak or absent.

The herbal composition of the present invention having the composition described above can be subjected to hot water extraction according to a conventional method to obtain a hot water extract, and the extract can be lyophilized to obtain a powdery dry extract. These extracts can be included as active ingredients to alleviate or treat primary dysmenorrhea. Hot water extraction is most preferably carried out for 2 to 3 hours at a temperature of 100 ~ 125 ℃.

In addition, the herbal composition of the present invention having the above composition can be extracted by using one or more solvents selected from the group consisting of water, an alcohol having 1 to 5 carbon atoms or an aqueous solution of alcohol according to a conventional method, and the extract can be obtained. Powdered dry extract obtained by lyophilization may be used for the relief and treatment of primary dysmenorrhea.

Such a herbal composition of the present invention is not particularly limited as long as it is prepared by including the above components, for example, it may have a formulation such as pills, tablets, capsules, liquids, health foods, health drinks and the like.

Hereinafter, the present invention will be described in detail with reference to production examples and examples, but the present invention is not limited only to these examples.

 Preparation Example 1 Herbal Medicine Composition

200g dried dried cow, 150g gyeuiin 100g, 70g creation, hyangbuja, dermis, hyssop, quince, betel nut, vigor, fennel, throat and licorice each 50g, rich 30g herbal medicine composition is prepared by mixing It was.

Preparation Example 2 Hot Water Extract of Herbal Composition

700 g of the mixture of Preparation Example 1 was added to a flask containing 10 liters of distilled water, followed by hot water extraction at 100 ° C. for 2 hours to obtain a hot water extract. The filtrate obtained by filtering the collected hot water extract with gauze was concentrated by a vacuum filter (Eyela Co., Japan) at 45 ℃ temperature, 1 atm to separate the extract.

<Test Example 1> alleviation of menstrual pain and evaluation of treatment efficacy

Thirty-seven women aged 17-40 who had primary dysmenorrhea visited the applicant's oriental clinic from October 2005 to November 2006, taking 100 ml of hot water extract of Preparation Example 2 twice a day for several days from the date of menstruation or menstruation. I did it. To evaluate the symptoms after taking, the results are shown in Table 1 below. Lower abdominal pain was a common symptom in all 31 patients. Back pain was reported in 11 of them, edema in 5 of them, and headache in 4 of them.

Preparation Example 2 (persons) Belly pain Symptoms disappear completely 13 Symptoms have improved greatly. 16 Symptoms slightly improved 2 No driveway 0 Back pain Symptoms disappear completely 5 Symptoms have improved greatly. 5 Symptoms slightly improved One No driveway 0 edema Symptoms disappear completely 0 Symptoms have improved greatly. 4 Symptoms slightly improved One No driveway 0 headache Symptoms disappear completely One Symptoms have improved greatly. 2 Symptoms slightly improved One No driveway 0

As can be seen from Table 1, the herbal composition of the present invention is excellent in alleviating and treating efficacy for all the belly pain, back pain, edema and headache belonging to the main symptoms of primary dysmenorrhea.

Experimental Example 2 Evaluation of Menstrual Pain Relief and Treatment Efficacy in Obese People

According to a conventional method, the constitution of 31 test subjects of Test Example 1 was evaluated, classified into normal and obese persons, and the change in menstrual pain according to the days of their administration was measured according to a conventional method, and the results are shown in FIGS. 1 and 2. Shown in the graph The measurement was performed by a conventional method of paperweight. As can be seen in Figures 1 and 2, menstrual pain showed a significant decrease over time whether or not normal or obese. For example, in Figures 1 and 2, when the taking period of the herbal composition of the present invention for 7 days before menstruation (X-axis) it can be seen that the degree of pain is alleviated by 25% (Y-axis). From this, it can be seen that the herbal composition according to the present invention is also effective for treating primary dysmenorrhea in obese women.

In the case of a woman having another disease at the same time, it is possible to further add to the herbal composition of the present invention the herbal medicine that is effective in treating the disease. For example, add constipation in patients with constipation, add rich people in patients with severe cold hands and feet, and add more precious cows in patients with severe blood clots. do.

According to the present invention by taking the herbal composition of the present invention in the form of a pill, tablets, capsules, liquids, health foods, health beverages, and the like by taking the menstrual pain, such as belly pain, back pain, swelling, headache that appear in most menstrual pain patients The symptoms can be treated well. In addition, such treatments can be used in combination with conventional bedding treatments.

Although the present invention has been described in detail only with respect to the described embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the technical spirit of the present invention, and such modifications and modifications belong to the appended claims. .

Claims (3)

10 to 12% by weight, 10 to 12% by weight, 7 to 9% by weight, 5 to 7% by weight, 5 to 7% by weight of dermis, 5 to 6% by weight of dew, 5 to 6% of quince, based on the total weight of the composition 7% by weight, 5-7% by weight, 5-7% by weight, 5-7% by weight, fennel 5-7%, licorice 5-7%, rich 3-4% by weight and residual amount Herbal composition for primary dysmenorrhea relief and treatment, characterized in that made to include. A herbal composition for alleviating and treating primary dysmenorrhea comprising the hot water extract prepared by hot water extraction of the composition of claim 1 as an active ingredient. A herbal composition for alleviating and treating primary dysmenorrhea, comprising a powdered extract prepared by lyophilizing the hot water extract of claim 2 as an active ingredient.

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