KR100901147B1 - 자궁암 환자의 방사선 치료 후 재발 예측용 마커, 그를포함하는 키트 및 마이크로어레이, 및 상기 마커를 이용한자궁암 환자 재발 여부 예측 방법 - Google Patents

Abstract

본 발명은 도 6에 기재된 50개의 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발 여부를 예측할 수 있는 마커, 그를 포함하는 키트 및 마이크로어레이, 및 상기 마커를 이용하여 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발 여부를 예측하는 방법을 제공한다.

자궁암, 마커, 마이크로어레이, 재발 예측, 키트, 방사선 치료

Description

자궁암 환자의 방사선 치료 후 재발 예측용 마커, 그를 포함하는 키트 및 마이크로어레이, 및 상기 마커를 이용한 자궁암 환자 재발 여부 예측 방법 {A marker for predicting recurrence of a uterine cancer patient treated with radiation therapy, a kit and microarray comprising the same and method for predicting recurrence of a uterine cancer patient after radiation therapy using the marker}

도 1은 자궁암 조직으로부터 재발 예측유전자의 발현 프로파일을 측정하기 위한 mRNA의 역전사와 DNA 칩에서 혼성화 및 분석 과정을 나타낸 모식도이다.

도 2는 자궁암 재발환자와 비재발 환자군 사이의 재발기간에 대한 카플란 메이어 플롯(Kaplan-Meier plot) 을 나타낸 모식도이다.

도 3는 자궁암 특이 유전자를 선별하기 위한 교차평가의 에러를 나타내는 도식화이다 (PAM (Prediction Analysis of Microarray) 분석 결과).

도 4은 자궁암 특이 유전자를 선별하기 위한 순열평가의 결과를 나타내는 도식화이다 (SAM (Significance Analysis of Microarray) 분석 결과).

도 5는 선별된 재발관련 예측유전자의 발현 프로파일링의 도식화이다.

도 6은 선별된 자궁암 재발 예측 유전자를 열거한 것이다.

본 발명은 방사선 치료를 받은 자궁암 환자의 재발 예측용 마커, 그를 포함하는 키트 및 마이크로어레이, 및 상기 마커를 이용한 방사선 치료 후 자궁암 환자의 재발 예측 방법에 관한 것이다.

자궁경부암(cervix cancer)은 1999년까지만 해도 국내 여성암 중 1위를 차지할 정도로 상당히 보편화된 암이였다. 자궁경부암은 0기에서 4기까지 나뉘고 0기 암을 상피내암이라고도 하며, 1기부터 4기 암을 침윤성 자궁경부암이라고 한다. 상피내암은 침윤성 자궁경부암보다 10년 정도 빠르게 35~40세 정도에서 호발하며 침윤성 자궁경부암은 30세 이후부터 증가하기 시작하여 50대에 정점에 달한 후 급격히 감소하는 경향을 보이는 것으로 알려져 있다. 국내의 경우 자궁경부암의 유병률 수준은 10만 명당 31명 정도이고 사망률은 10만 명당 6.8명 수준으로 지난 10년간 큰 변화를 보이지 않았다. 발생률과 유병률의 빈도를 연령별로 보면 50대, 60대, 40대의 순이며, 발생률은 미국의 3배, 일본의 2.5배, 브라질의 1/3 수준이며 자궁경부암으로 인한 사망률이 암 사망률에서 차지하는 비율이 6%로 미국, 일본, 스위스 등의 2% 내외에 비하여 높은 실정이다. 현재 자궁경부암 발생에 관해서는 성적 접촉성 감염질환 모델이 가장 널리 인정되고 있으며 조기에 시작된 성적 활동, 다수의 성교 상대자, 남성 요인, 인유두종 바이러스(human papillomavirus, HPV) 감염, 에이즈 바이러스(human immunodeficiency virus) 감염 등이 자궁경부암 발생의 위험 요인으로 알려져 있다. 자궁경부암은 자궁암의 90% 이상을 차지하는 것으로서 한국 여성에 있어서 가장 발생 및 사망 빈도가 높은 악성종양이다. 특히 최근에는, 사람 파릴로마바이러스(human papillomavirus; HPV) 16형 및 18형의 감염이 발암기전에서 가장 중요하게 작용하는 인자로 밝혀졌는데, 자궁암 환자 중에서 HPV 16형의 감염율은 50-70% 정도에 이르고 18형의 감염율은 15-25%에 이르는 것으로 보고되어 있으나, 전이암의 경우를 비교해보면 16형 감염환자의 25% 정도, 18형 감염환자의 50% 이상이 전이암에 걸려있는 것으로 보인다. 선진국의 경우 확진시의 암이 진행 초기인데 반해 우리나라의 경우 중기 이후인 경우가 많아 그만큼 치료가 어렵고 사망률도 더 높을 것으로 예상된다. 자궁암의 치료는 주로 1기와 2기 초기까지는 수술이 원칙이며 경우에 따라 방사선치료를 추가한다. 그러나 2기 말기부터는 방사선치료가 표준 치료이며(여기에는 강내 치료가 대부분 포함) 필요에 따라 항암제 치료가 추가된다. 과거에는 자궁경부암에 항암제 치료가 별 효과가 없다고 하는 것이 일반적인 견해였지만 최근에는 항암제 치료가 효과적이라고 하는 많은 연구 보고들이 있어서 많은 병원에서 항암제 치료를 시행하고 있다.

자궁경부암의 치료 후 재발률은 1년 내 50%, 2년 내 25%, 3년 내 15% 정도로서, 약 85%의 환자가 3년내 재발을 한다. 특히 자궁경부암의 방사선 치료 후의 재발율 또한 55%가 넘는다. 재발한 자궁경부암의 치료는 기존에 받았던 치료의 종류와 환자의 상태에 따라 다르게 결정되는데, 일반적으로 1차 치료로 수술을 했다면 재발시에는 방사선 치료를, 1차 치료로 방사선 치료를 했다면 수술을 고려하며, 두 가지 치료가 모두 불가능할 경우 항암화학요법을 시행하게 된다. 그러나 표준적인 치료법은 없으며 재발부위에 따라 각각에 대한 적절한 치료를 실시하는데, 일반적 으로 병을 고치는 것보다 증상을 경감시기는 것을 목적으로 하는 치료법이다.

cDNA 마이크로어레이 테크놀로지의 적용은 자궁암을 포함하는 인간 암의 발생에서 활발하게 참여하는 유전자의 측정과 그 유전자에서 발현되는 단백질 또는 효소를 측정함으로써 암 진단이나 치료 후 재발 혹은 생존기간의 예측을 분자 수준에서 가능하도록 하였다. 비록 자궁암 치료 후 재발 여부의 예측이 그들의 병리학적 연구결과에 의해 정확하게 결정되는 것은 어렵지만, 그들의 분자 발현 프로파일의 차이점에 의한 재발이 발생하지 않은 조직과 재발이 발생한 조직간의 구별은 가능하다. 왜냐하면, 분자 발현 프로파일의 차이는 자궁암 재발에 포함된 유전자들의 정확한 세트(set)를 선택하는 것이 가능케 하기 때문이다. 또한 이것은 치료에 대한 적절한 목표를 설정하는 것을 용이하게 할 수 있고 따라서 자궁암 치료 후 환자의 효과적인 처치를 극대화할 것이다.

자궁암을 포함한 인간 암에 관련된 유전자를 마이크로어레이 방법으로 규명하기 위하여 현재까지의 연구들은 유전자 발현의 패턴을 분석하는데 매우 유용한 방법인 언수퍼바이즈드 클러스터링 알고리즘(unsupervised clustering algorithm) 및 수퍼바이즈드 알고리즘을 개발하였다. 언수퍼바이즈드 클러스터링 분석은 샘플 내에 존재하는 내재적인 생물학적 의미를 추출하는데 매우 유용하나, 그 측정결과의 통계적인 정확성을 제공하기 어려울 뿐 아니라, 측정되는 유전자의 수를 적절하게 조절하기 힘든 단점이 있다. 수퍼바이즈드 러닝 알고리즘(supervised learning algorithm)의 경우 샘플을, 차이를 보고자 하는 군으로 분류하여 분석할 수 있다는 매우 강력한 장점 외에도 분석 결과를 이용하여 신규 샘플을 검증할 수 있다는 특 징을 가지고 있다. 최근에는 자궁암을 포함한 다양한 암의 마이크로어레이 프로파일링 분석에 이 두 가지 방법이 모두 적용되고 있으며, 신규 샘플의 진단 및 예측에 모두 성공적으로 사용되고 있다.

자궁암에서 유전자 발현 프로파일의 분석은 마이크로어레이를 이용한 몇몇의 연구에서 이미 보고되었다. 하지만 유전자 프로파일을 이용한 자궁암 환자의 재발예측과 같은 연구는 거의 시행되고 있지 않다. 마이크로어레이를 이용한 자궁암 환자의 재발 예측 연구가 거의 전무한 반면, 기존의 임상병리학적 기준에 따른 자궁암 환자의 위험도 분석은 이미 오래전부터 연구되어 오고 있으며 그 효용성에 대해 전세계의 평가가 현재 이루어지고 있는 중이다. 임상항목에 따른 자궁암 환자의 위험도 예측은 3-4 개의 임상항목의 수치적 평가를 합산해서 평가하는 방식을 따르고 있다. 이 방식은 그 간결함 때문에 많이 이용되고 있으나, 그 정확도와 보편성에서 많은 문제점을 가지고 있다. 임상항목 수치의 주관적인 판단, 자궁암의 다양성을 평가하지 못하는 문제 등이 그 주 원인이다. 본 발명은 이런 단점을 극복하기 위해, 자궁암 조직의 유전자 발현 패턴이라는 객관적인 요소를 바탕으로 자궁암 환자를 분류함으로써 주관적 요소를 배제하였으며, 1-2 개 유전자의 발현도를 평가하는 것이 아니라 수십 개의 유전자의 발현 패턴을 동시에 측정하는 프로파일 방식을 사용하였다.

따라서, 본 발명자들은 cDNA 마이크로어레이 분석을 통하여 자궁암 환자의 방사선 치료 후 재발을 예측할 수 있는 유전자를 규명함으로써, 본 발명을 완성하게 되었다.

본 발명은 자궁암 (uterine cancer)으로 판명된 환자들 중 방사선 치료를 받은 사람의 재발 여부를 마이크로어레이를 통한 유전자 발현의 프로파일링을 통해 예측하고자 하는 것이다. 마이크로어레이를 이용해 선별한 재발관련 예측유전자는 여러가지 분석법을 통한 반복성과 효용성이 유의적임을 보여야 하며, 실제 임상에 적용할 수 있을 정도의 수월성, 보편성 및 타당성을 확보해야 한다.

따라서, 본 발명의 목적은 도 6에 기재된 50개의 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 마커를 제공하는 것이다.

본 발명의 다른 목적은 본 발명의 마커를 포함하는 키트 및 마이크로어레이를 제공하는 것이다.

본 발명의 또 다른 목적은 본 발명의 마커를 이용하여 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발 여부를 예측하는 방법을 제공하는 것이다.

본 발명은 도 6에 기재된 50개의 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 마커를 제공하는 것이다.

본 발명은 방사선 치료를 받은 자궁암 환자의 재발의 예측을 위한 것으로, 자궁암세포에서 분리 추출한 mRNA를 역전사시켜 수득한 cDNA에 Cy5-dUTP를 결합시키고, 대조군으로 태반에서 분리 정제한 mRNA를 역전사시켜 수득한 cDNA에 Cy3- dUTP를 결합시켜 혼합한 후, DNA 마이크로어레이와 혼성화시켜 그 결과를 컴퓨터 소프트웨어를 이용하여 처리하여 자궁암 환자의 재발을 예측할 수 있는 유전자를 탐색한다.

구체적으로, 자궁암 환자 중 방사선 치료를 받을 환자 22 명으로부터 종양조직을 채취하여 RNA를 분리 정제하였다. 한편, DNA 칩 실험에 사용할 기준으로 태반으로부터 정제한 RNA를 대조 RNA로 사용하였다. 이렇게 조직으로부터 분리한 RNA와 대조 RNA를 역전사(reverse transcription)시켜 cDNA를 제조하였는데, 이 과정에서 Cy5-dUTP, Cy3-dUTP를 cDNA에 각각 결합하도록 하였다 (도 1 참고). 이렇게 대조 조직을 중간에 삽입시킨 이유는 분석의 용이성을 증대시키고, 분석 결과의 타 기관과의 상호 비교를 가능하게 하기 위해서였다. 이렇게 혼성화시킨 DNA 칩은 레이저 스캐너를 이용하여 각 스폿에서의 Cy3 와 Cy5의 강도 (intensity)를 측정하였다. 이 두 가지 종류의 형광강도의 상대적인 비율을 컴퓨터 소프트웨어(IMAGENE program)를 이용하여 수치화하여 발현도를 측정하였다.

본 발명에 사용된 DNA 마이크로어레이 분석방법을 설명하면 다음과 같다.

방사선 치료 이후 환자의 재발여부를 추적한 뒤 재발군과 재발하지 않은 군으로 환자를 분류하였다. 두 군 사이의 재발기간에 대한 카플란 메이어 플롯(Kaplan-Meier plot) 을 비교하면 대부분의 재발이 방사선 치료후 12개월 안에 발생 했음을 확인할 수 있다 (도 2 참조). 두 군으로 분류된 환자군에서 발현도의 차이를 보이는 유전자를 선별하기 위하여 수퍼바이즈드 클러스터링 분석인 PAM (Prediction Analysis of Microarray) 분석(도 3 참조) 과 SAM (Significance Analysis of Microarray) 분석 (도 4 참조)을 수행하였다. 두 가지 방법으로 선별한 유전자 중 공통으로 발현되는 유전자를 선별하여 통계적으로 정렬된 상위 50개의 유전자를 추출하였다 (도 6 참조). 추출된 유전자 마커는 하기와 같다: NM_016208 (VPS28 protein; 서열번호 1), NM_005147 (tumorous imaginal discs (Drosophila) homolog; 서열번호 2), NM_016334 (putative G-protein coupled receptor; 서열번호 3), NM_003392 (wingless-type MMTV integration site family, member 5A; 서열번호 4), NM_002933 (ribonuclease, RNase A family, 1 (pancreatic); 서열번호 5), NM_007271 (serine threonine protein kinase; 서열번호 6), NM_001540 (heat shock 27kD protein 1; 서열번호 7), AK026164 (cDNA: FLJ22511 fis, clone HRC11837, highly similar to HUMMYLCB Human non-muscle myosin alkali light chain; 서열번호 8), NM_002305 (lectin, galactoside-binding, soluble, 1; 서열번호 9), AW015185 (UI-H-BI0-aap-a-03-0-UI.s1 cDNA, 3' end; 서열번호 10), BG679661 (602626518F1 cDNA, 5' end; 서열번호 11), AB067484 (mRNA for KIAA1897 protein, partial cds; 서열번호 12), U47077 (DNA-dependent protein kinase catalytic subunit; 서열번호 13), AA878376 (oe65b04.s1 cDNA, 3' end; 서열번호 14), NM_004336 (budding uninhibited by benzimidazoles 1 (yeast homolog); 서열번호 15), NM_016219 (alpha 1,2-mannosidase; 서열번호 16), W67867 (zd38e07.r1 cDNA, 5' end; 서열번호 17), NM_003254 (tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); 서열번호 18), NM_000477 (albumin; 서열번호 19), NM_001068 (topoisomerase (DNA) II beta (180kD); 서열번호 20), NM_004935 (cyclin-dependent kinase 5; 서열번호 21), NM_014708 (KIAA0166 gene product; 서열번호 22), NM_005620 (S100 calcium-binding protein A11 (calgizzarin); 서열번호 23), NM_002106 (H2A histone family, member Z; 서열번호 24), NM_002875 (RAD51 (S. cerevisiae) homolog (E coli RecA homolog); 서열번호 25), NM_002648 (pim-1 oncogene; 서열번호 26), NM_004270 (cofactor required for Sp1 transcriptional activation, subunit 9; 서열번호 27), AF196969 (phenylalkylamine binding protein gene; 서열번호 28), AB029031 (mRNA for KIAA1108 protein; 서열번호 29), BE883627 (601507306F1 cDNA, 5' end; 서열번호 30), NM_005423 (trefoil factor 2 (spasmolytic protein 1); 서열번호 31), AF217536 (truncated mevalonate kinase mRNA; 서열번호 32), NM_033418 (hypothetical protein MGC9084; 서열번호 33), BC001209 (Homo sapiens, clone MGC:3214 IMAGE:3502620; 서열번호 34), NM_012406 (PR domain containing 4; 서열번호 35), BI551315 (603193129F1 cDNA, 5' end; 서열번호 36), BI439120 (ic26g10.y3 cDNA, 5' end; 서열번호 37), NM_032300 (hypothetical protein MGC10854; 서열번호 38), D17525 (precursor of P100 serine protease of Ra-reactive factor; 서열번호 39), NM_025245 (pre-B-cell leukemia transcription factor 4; 서열번호 40), NM_017571 (hypothetical protein (LOC55580); 서열번호 41), NM_016565 (E2IG2 protein (LOC51287); 서열번호 42), NM_002938 (ring finger protein 4; 서열번호 43), M83822 (Human beige-like protein; 서열번호 44), NM_002153 (hydroxysteroid (17-beta) dehydrogenase 2; 서열번호 45), NM_032747 (hypothetical protein MGC14697; 서열번호 46), NM_032047 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; 서열번호 47), NM_001831 (clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J; 서열번호 48), NM_032044 (regenerating gene type IV; 서열번호 49) 및 NM_002660 (phospholipase C, gamma 1; 서열번호 50).

이들 유전자들은 모두 서열이 공지되어 있는 것으로, 미국 NIH에서 주관하는 GenBank에 등록되어 있다. 따라서, 상기 유전자들은 등록번호(accession number)를 입력하여 GenBank로부터 그 유전자 서열을 입수할 수 있으며, 등록번호는 도 6에 기재되어 있다. 본 발명의 마커는 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 폴리뉴클레오티드로서, 도 6에 기재된 50개의 폴리뉴클레오티드로 구성된 군으로부터 선택된 하나 이상의 폴리뉴클레오티드를 말하며, 바람직하게는 10개 이상, 더욱 바람직하게는 20개 이상, 더 더욱 바람직하게는 30개 이상, 여전히 더욱 바람직하게는 40개 이상, 가장 바람직하게는 도 6에 기재된 50개 폴리뉴클레오티드 세트를 포함한다. 즉, 50개 폴리뉴클레오티드 세트 전부를 이용하면 보다 효율적으로 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 것이다.

본 발명은 본 발명에 따른 마커를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 키트를 제공한다.

본 발명의 키트는 또한, 도 6에 기재된 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드의 센스 및 안티센스 프라이머를 포함할 수 있다. 상기 폴리뉴클레오티드의 센스 및 안티센스 프라이머를 이용하여 PCR 증폭을 실시하여 원하는 생성물의 생성 정도를 통해 자궁암 환자의 재발 기간을 예측할 수 있는 것이다.

본 발명에 있어서, "프라이머"는 카피하려는 핵산 가닥에 상보적인 단일 가닥 올리고뉴클레오티드 서열을 말하며, 프라이머 연장 산물의 합성을 위한 개시점으로서 작용할 수 있다. 상기 프라이머의 길이 및 서열은 연장 산물의 합성을 시작하도록 허용해야 한다. 바람직하게는, 상기 프라이머의 길이는 약 5-50 뉴클레오티드일 수 있다. 구체적인 길이 및 서열은 요구되는 DNA 또는 RNA 표적의 복합도(complexity)뿐만 아니라 온도 및 이온 강도와 같은 프라이머 이용 조건에 의존할 것이다. 상기 폴리뉴클레오티드의 센스 및 안티센스 프라이머 서열은 당업자라면 마커만 결정되면 용이하게 디자인할 수 있는 것이다. 또한, PCR 조건 등은 당업계에 공지된 것을 기초로 변형할 수 있다. 또한, 증폭되는 PCR 산물의 크기는 약 500-1000 bp가 되는 것이 바람직하다. 이는 증폭된 PCR 산물의 확인이 용이하기 때문이다.

본 발명의 키트는 또한, 도 6에 기재된 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드에 상보적인 프로브를 포함할 수 있다. 상기 폴리뉴클레오티드와 상보적인 프로브를 이용하여 혼성화를 실시하여, 혼성화 여부를 통해 방사선 치료를 받은 자궁암 환자의 재발 기간을 예측할 수 있는 것이 다.

본 명세서에 있어서, "프로브"란 상보적인 단일가닥 표적 서열과 혼성화하여 이중가닥 분자 (혼성체)를 형성하는 단일가닥 핵산 서열을 말한다. 본 명세서에 있어서, 프로브로서 이용된 올리고뉴클레오티드는 또한 뉴클레오티드 유사체(analogue), 예를 들면, 포스포로티오에이트(phosphorothioate), 알킬포스포로티오에이트 또는 펩티드 핵산(peptide nucleic acid)를 포함할 수 있다. 본 발명의 프로브의 디자인은 당업계에 공지된 방법을 이용하여 수행할 수 있으며, 프로브의 길이는 약 5-50 뉴클레오티드일 수 있다. 구체적인 길이 및 서열은 요구되는 DNA 또는 RNA 표적의 복합도(complexity)뿐만 아니라 온도 및 이온 강도와 같은 프로브 이용 조건에 의존할 것이다. 상기 폴리뉴클레오티드에 대한 프로브 서열은 당업자라면 마커만 결정되면 용이하게 디자인할 수 있는 것이다. 또한, 프로브 혼성화 조건 등은 당업계에 공지된 것을 기초로 변형할 수 있다. 본 명세서에 있어서, "혼성화"란 핵산의 2개의 상보적 가닥이 조합하여 이중가닥 분자 (혼성체)를 형성하는 과정을 말한다. 상기 혼성화는 높은 엄격도 혼성화 조건하에서 수행될 수 있다. 본 구체예에서, 상기 높은 엄격도 혼성화 조건은 바람직하게는 65℃에서 동일한 몰의 Na₂HPO₄ 및 NaH₂PO₄, 1mM EDTA 및 0.02% 소듐 도데실 설페이트를 포함하는 0.12 M 포스페이트 버퍼를 포함하는 것이다.

또한, 본 명세서에 있어서, "엄격도 (stringency)"란 혼성화 및 그 후의 처리 단계 동안 존재하는 온도 및 용매 조성을 기술하기 위하여 사용되는 용어이다. 높은 엄격도 조건하에서는 고도로 상동적인 핵산 혼성체가 형성될 것이다. 즉, 충분한 정도의 상보성이 없는 혼성체는 형성되지 않을 것이다. 따라서, 분석 조건의 엄격도는 혼성체를 형성하는 2 핵산 가닥 사이에 필요한 상보성의 양을 결정한다. 엄격도는 표적과 비표적 핵산과 형성된 혼성체 사이의 안정성의 차이를 최대화하기 위하여 선택된다.

본 발명의 키트는 또한, 도 6에 기재된 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드에 의해 코딩되는 단백질을 인식하는 항체를 포함할 수 있다. 상기 키트는 상기 항체, 기질, 적당한 완충용액, 발색 효소 또는 형광물질로 표지된 2차 항체, 발색 기질 등을 포함할 수 있다. 상기에서 기질은 니트로셀룰로오스 막, 폴리비닐 수지로 합성된 96 웰 플레이트, 폴리스티렌 수지로 합성된 96 웰 플레이트 및 유리로 된 슬라이드글라스 등이 이용될 수 있고, 발색효소는 퍼옥시다아제(peroxidase), 알칼라인 포스파타아제(Alkaline Phosphatase)가 사용될 수 있고, 형광물질은 FITC, RITC 등이 사용될 수 있고, 발색 기질액은 ABTS(2,2'-아지노-비스(3-에틸벤조티아졸린-6-설폰산)) 또는 OPD(o-페닐렌디아민), TMB(테트라메틸 벤지딘)가 사용될 수 있다.

본 발명의 상기 방사선 치료를 받은 자궁암 환자 재발 예측용 폴리뉴클레오티드에 대한 항체는 각 유전자를 통상적인 방법에 따라 발현벡터에 클로닝하여 상기 마커 유전자에 의해 코딩되는 단백질을 얻고, 얻어진 단백질로부터 통상적인 방법에 의해 제조될 수 있다. 여기에는 상기 단백질에서 만들어질 수 있는 부분 펩타이드도 포함되며, 본 발명의 부분 펩타이드로는, 최소한 7개 아미노산, 바람직하 게는 9개 아미노산, 더욱 바람직하게는 12개 이상의 아미노산을 포함한다. 본 발명의 항체의 형태는 특별히 제한되지 않으며 폴리클로날 항체, 모노클로날 항체 또는 항원 결합성을 갖는 것이면 그것의 일부도 본 발명의 항체에 포함되고 모든 면역 글로불린 항체가 포함된다. 나아가, 본 발명의 항체에는 인간화 항체 등의 특수 항체도 포함된다.

본 발명은 또한, 본 발명에 따른 마커 또는 상기 마커에 의해 코딩되는 단백질을 인식하는 항체를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 마이크로어레이를 제공한다. 본 발명의 마이크로어레이는 본 발명의 마커 또는 항체를 이용하여 당업계에서 통상적으로 사용되는 제조 방법에 의하여 용이하게 제조될 수 있다.

본 발명의 마이크로어레이에 있어서, "마이크로어레이"란 기판 상에 폴리뉴클레오티드 또는 항체 그룹이 높은 밀도로 고정화되어 있는 것으로서, 상기 폴리뉴클레오티드 또는 항체 그룹은 각각 일정한 영역에 고정화되어 있는 마이크로어레이를 의미한다. 이러한 마이크로어레이는 당업계에 잘 알려져 있다. 마이크로어레이에 관하여는 예를 들면, 미국특허 제5,445,934호 및 제5,744,305호에 개시되어 있으며, 이들 특허의 내용은 참조에 의하여 본 명세서에 포함되어진다. 상기 마커에 대하여는 상기 기재한 바와 같다.

용어 "기판"은 혼성화 특성을 보유하고, 혼성화의 배경 수준이 낮게 유지되는 조건 하에 마커 또는 올리고뉴클레오티드 프로브가 커플링될 수 있는 임의의 기판을 말한다. 통상적으로, 상기 기판은 미세역가(microtiter) 플레이트, 막(예를 들면, 나일론 또는 니트로셀룰로오스) 또는 미세구(비드) 또는 칩일 수 있다. 막에 적용 또는 고정 전에, 핵산 프로브를 변형시켜 고정화를 촉진시키거나 혼성화 효율을 개선시킬 수 있다. 상기 변형은 단독중합체 테일링(homopolymer tailing), 지방족기, NH₂ 기, SH 기 및 카르복실기와 같은 상이한 반응성 작용기와의 커플링, 또는 바이오틴, 합텐 또는 단백질과의 커플링을 포함할 수 있다.

본 발명은 또한, 자궁암 세포로부터 도 6에 기재된 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드의 발현 수준을 측정하는 단계 및 상기 측정된 발현 수준을 정상 세포의 발현 수준과 비교하여 방사선 치료를 받은 자궁암 환자의 재발을 예측하는 단계를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측하는 방법을 제공한다.

상기 방법에서, 바람직하게는 10개 이상, 더욱 바람직하게는 20개 이상, 더 더욱 바람직하게는 30개 이상, 여전히 더욱 바람직하게는 40개 이상, 가장 바람직하게는 도 6에 기재된 50개 폴리뉴클레오티드 세트를 포함한다. 즉, 50개 폴리뉴클레오티드 세트 전부를 이용하면 보다 효율적으로 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 것이다.

본 발명은 또한, 자궁암 세포로부터 도 6에 기재된 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드의 발현 수준을 측정하는 단계 및 상기 측정된 발현 수준을 정상 세포의 발현 수준과 비교하는 단계를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측하기 위한 폴리뉴 클레오티드를 확인하는 방법을 제공한다.

이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하기로 한다. 이들 실시예는 단지 본 발명을 예시하기 위한 것이므로, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지는 않는다.

실시예 1: 시험군 및 시험조직 샘플의 선택

시험용 표본은 원자력병원에서 자궁암 환자 중 방사선 치료를 받을 22명의 환자로부터 수득하였으며, 표본 채취 후 환자는 모두 방사선 치료를 받았다. 연구 목적으로 표본과 임상병리학적 데이터를 사용하겠다는 동의를 환자로부터 받았다. 모든 조직은 외과적으로 적출되고 즉시 액체 질소에서 재빨리 냉각한 후 영하 80℃에서 저장하였다. RNA는 시험 매뉴얼 (Trizol, Gibco/BRL)에 따라 페놀/클로로포름 추출에 의해서 냉각된 조직으로부터 분리되었다. 총 RNA의 품질(quality)은 아가로즈 겔 전기영동 후 28S와 18S RNA 사이의 밴드 비율로부터 판단하였다.

실시예 2: cDNA 마이크로어레이

실험에 사용한 마이크로어레이는 인간 cDNA 클론 총 14,080개로 구성되어 있으며, 생명공학연구소 인간 유전체 사업단 인프라팀으로부터 제공받았다. 마이크로어레이 실험 방법은 3DNA 어레이 검출 키트 (Genisphere Inc. PA, USA)를 사용하여 제조사가 제시하는 방법에 따라 수행하였다. 간단히 말하면, 각각 실험용 RNA 10㎍과 일반적인 대조 태반 RNA 10㎍을 각각 2 시간 동안 역전사효소를 사용하여 역전사시키고 Cy5-dUTP와 Cy3-dUTP로 태깅하였다. 두 종류의 cDNA는 마이크로콘 칼럼 (Millipore, Bedford, MA)을 통과시켜 정제하였다. 대조 샘플과 실험용 샘플 로부터 정제한 형광 cDNA는 ExpressHyb^TM 하이브리드 용액 (BD Biosciences Clontech, Palo Alto, CA, USA)과 혼합하여 65℃에서 하룻밤 동안 반응한 후 스캔어레이 스캐너 (PerkinElmer, Boston, MA, USA)를 사용하여 스캔하였다.

실시예 3: 데이터 분석 및 예측유전자 선별

스캔한 이미지 파일로부터 IMAGENE 4.0 (Biodiscovery, Marina del Rey, CA, USA)를 이용하여 수치화된 데이터를 얻었고, 형광 강도 (intensity)와 스폿 위치를 고려하여(spatially dependent method) 표준화 (normalization)하였다. 적어도 샘플의 80% 이상에서 측정되지 않은 유전자는 차후 분석에서 배제하였다. 재발한 환자군의 재발기간에 대한 분포는 카플란-메이어 (Kaplan-Meier) 플롯 (plot)을 통하여 확인하였다. 발현 비율은 클러스터 프로그램 (Cluster)의 사용으로 계층적으로 클러스터링하였으며, 트리뷰 (treeview) 프로그램을 사용하여 도식화하였다. 재발에 관련된 유전자를 선별하기 위해서 SAM 과 PAM 프로그램 (Stanford University)을 이용한 분석을 사용하였다. 재발에 관련된 예측유전자 군을 선별하기 위해 마이크로어레이에 부착되어 있는 유전자 프로브의 발현도를 개개의 독립변수로 설정한 뒤 분석하였으며, 얻어진 재발 예측유전자를 대상으로 클러스터링을 수행하여 유전자 발현 패턴에 따라 두 개의 군으로 분류하였다.

실시예 4: 예측유전자에 의한 방사선 치료를 받은 자궁암 환자의 재발 예측

PAM 분석 및 SAM 분석에 의해 얻어진 예측유전자를 통계치의 순위별로 정렬을 하여 상위 유전자 50종을 선별하였으며 (도 6), 선별한 유전자를 언수퍼바이즈 드 클러스터링 알고리즘 (Unsupervised clustering algorithm) 방법에 의해 클러스터링하였다 (도 5). 클러스터링 결과, 예측유전자들의 발현 패턴에 의해 샘플이 크게 두 개의 군으로 분류된다는 것을 확인하였다 (도 5).

본 발명에 따르면, 자궁암으로 진단 받은 환자가 방사선 치료를 받을 경우, 자궁암 조직을 이용하여 유전자의 발현도를 기준으로 환자의 수술 후 재발을 예측할 수 있도록 함으로써, 자궁암으로 방사선 치료를 받은 환자가 적절한 예후 조치를 받는 것을 가능하게 할 수 있다.

본 발명은 자궁암 조직의 유전자 발현 패턴이라는 객관적인 요소를 바탕으로 자궁암 환자를 분류함으로써 주관적 요소를 배제하였으며, 1-2개 유전자의 발현도를 평가하는 것이 아니라 수십 개의 유전자의 발현 패턴을 동시에 측정하는 프로파일 방식을 사용함으로써, 자궁암의 다양성을 고려할 수 있는 장치를 가지고 있어서 기존의 자궁암 환자의 예후 예측보다 뛰어난 분류법으로 평가된다. 한편, 기존의 임상분류와 본 예측유전자의 프로파일링 방식을 결합할 경우, 매우 우수한 자궁암 환자의 분류가 가능하다는 것도 확인하였다. 따라서, 기존의 임상 분류를 선호하는 의료진에게도 큰 거부감 없이 예측유전자에 의한 분류법이 이용될 수 있을 것으로 기대한다. 이런 예측유전자의 평가에 의해 단기 재발군에 포함될 경우, 기존 방식의 치료보다 더 적극적인 치료를 시행할 수 있으며, 장기 재발군에 포함될 경우 중복적인 치료를 최대한 줄여서 소모적인 의료비를 절감할 수 있는 효과를 기대할 수 있을 것이다.

따라서, 방사선 치료를 받은 자궁암 환자의 자궁암 조직으로부터 예측유전자의 발현 패턴인 프로파일링을 분석하여 재발을 예측할 수 있는 전략을 제시하여 환자의 예후 치료에 적극적으로 활용을 할 수 있을 것이다.

<110> Korea institute of radiological & medical sciences <120> A marker for predicting recurrence of a uterine cancer patient treated with radiation therapy, a kit and microarray comprising the same and method for predicting recurrence of a uterine cancer patient after radiation therapy using the marker <130> P074730 <160> 50 <170> KopatentIn 1.71 <210> 1 <211> 1065 <212> DNA <213> Homo sapiens <400> 1 cgctgaccga gcgcaccccg cccccggcgc catcttcccg accgcgagcc gtccaggtct 60 cagtgctgtg ccccccccag agcctagagg atgtttcatg ggatcccagc cacgccgggc 120 ataggagccc ctgggaacaa gccggagctg tatgaggaag tgaagttgta caagaacgcc 180 cgggagaggg agaagtacga caacatggca gagctgtttg cggtggtgaa gacaatgcaa 240 gccctggaga aggcctacat caaggactgt gtctccccca gcgagtacac tgcagcctgc 300 tcccggctcc tggtccaata caaagctgcc ttcaggcagg tccagggctc agaaatcagc 360 tctattgacg aattctgccg caagttccgc ctggactgcc cgctggccat ggagcggatc 420 aaggaggacc ggcccatcac catcaaggac gacaagggca acctcaaccg ctgcatcgca 480 gacgtggtct cgctcttcat cacggtcatg gacaagctgc gcctggagat ccgcgccatg 540 gatgagatcc agcccgacct gcgagagctg atggagacca tgcaccgcat gagccacctc 600 ccacccgact ttgagggccg ccagacggtc agccagtggc tgcagaccct gagcggcatg 660 tcggcgtcag atgagctgga cgactcacag gtgcgtcaga tgctgttcga cctggagtca 720 gcctacaacg ccttcaaccg cttcctgcat gcctgagccc ggggcactag cccttgcaca 780 gaagggcaga gtctgaggcg atggctcctg gtcccctgtc cgccacacag gccgtggtca 840 tccacacaac tcactgtctg cagctgcctg tctggtgtct gtctttggtg tcagaacttt 900 gggggccggg cccctcccca caataaagat gctctccgac cttcaaaaaa aaaaaaaaaa 960 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1020 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 1065 <210> 2 <211> 2704 <212> DNA <213> Homo sapiens <400> 2 gatggctgcg cggtgctcca cacgctggtt gctggtggtt gtggggaccc cgcggctgcc 60 ggctatatcg ggtagagggg cccggccgcc cagggagggc gtggtggggg catggctgag 120 ccgcaagctg agcgtccccg cctttgcgtc ttccctgacc tcttgcggcc cccgagcgct 180 gctgacattg agacctggtg tcagcctcac aggaacaaaa cattaccctt tcatttgtac 240 tgcctccttc cacacgagtg cccctttggc caaagaagat tattatcaga tattaggagt 300 gcctcgaaat gccagccaga aagagatcaa gaaagcctat tatcagcttg ccaagaagta 360 tcaccctgac acaaataagg atgatcccaa agccaaggag aagttctccc agctggcaga 420 agcctatgag gttttgagtg atgaggtgaa gaggaagcag tacgatgcct acggctctgc 480 aggcttcgat cctggggcca gcggctccca gcatagctac tggaagggag gccccactgt 540 ggaccccgag gagctgttca ggaagatctt tggcgagttc tcatcctctt catttggaga 600 tttccagacc gtgtttgatc agcctcagga atacttcatg gagttgacat tcaatcaagc 660 tgcaaagggg gtcaacaagg agttcaccgt gaacatcatg gacacgtgtg agcgctgcaa 720 cggcaagggg aacgagcccg gcaccaaggt gcagcattgc cactactgtg gcggctccgg 780 catggaaacc atcaacacag gcccttttgt gatgcgttcc acgtgtagga gatgtggtgg 840 ccgcggctcc atcatcatat cgccctgtgt ggtctgcagg ggagcaggac aagccaagca 900 gaaaaagcga gtgatgatcc ctgtgcctgc aggagtcgag gatggccaga ccgtgaggat 960 gcctgtggga aaaagggaaa ttttcattac gttcagggtg cagaaaagcc ctgtgttccg 1020 gagggacggc gcagacatcc actccgacct ctttatttct atagctcagg ctcttcttgg 1080 gggaacagcc agagcccagg gcctgtacga gacgatcaac gtgacgatcc cccctgggac 1140 tcagacagac cagaagattc ggatgggtgg gaaaggcatc ccccggatta acagctacgg 1200 ctacggagac cactacatcc acatcaagat acgagttcca aagaggctaa cgagccggca 1260 gcagagcctg atcctgagct acgccgagga cgagacagat gtggagggga cggtgaacgg 1320 cgtcaccctc accagctctg gtggcagcac catggatagc tccgcaggaa gcaaggctag 1380 gcgtgaggct ggggaggacg aggagggatt cctttccaaa cttaagaaaa tgtttacctc 1440 atgatatccc agccgaggaa aaagatccac tggaaactag gccgggaagc agcagcccct 1500 ccaagggcca gggcacctgg gagacgggag gattccagaa cagcagcact gagctcccac 1560 ccgcagagcc tctggacggc cttggcaaca gcaaaatcat gggacaacac ctctctccac 1620 ggaaaggtca cagtggacag cccgggcagt aggatgcagc cccagaggct ggtggcagtt 1680 tcctgtccat tggtaggtga cggcccctgg ctcaggcaga gggagatggt tagactcttg 1740 cagggctaaa actctaattt ggaattgaat attgtggata tcttagttaa aggccatgct 1800 tacagcttag aaatgaagcc ttaagctgca tcaagttacg aagtgattaa tttccttctc 1860 agcaaacctc cgggaggttc cagaatgagt tcttcctgac aggttgtctt cactgggagc 1920 gtggggcccc caggccccac cagcaccgtc ctcccctaat gaggggccct gccgaggcat 1980 cagctgctct gctcagttag tttttattcc cggggtacca agcagctgca cagtcggtgc 2040 ctgggaggca cgtagaggcc cagagagtcc ctgggggttc tgctctgacc gtgtgggtgg 2100 tgatccttgt caggatgtac agtccttgct cccaccccat ccaggatggc cgcctgtccc 2160 tgactattga gtcctgttgt tgtaagccag gcatggaggg ctcctgccct tctgctgagc 2220 cacagcccat tgcagcactg tgctggccag acttcagctg ccttgggaac tgaagccctg 2280 ccactgttgc tagtcagggg cttggttctc ccacttacac tgttgacatc tattttctga 2340 agtgtgttta aattattcag tgctaatcat tgttttttcc tttgtaaatg ttgattcaga 2400 aaaggaaagc acaggctaag cagttgaagg ttccccacca ttcagtgaga gcagaacccc 2460 cattccccag cctctgctgg tagcatgtcg cagtttccat gtgtttcagg atcttcgggc 2520 tgtcgttaga caggttaatg aagaacactt ctcaacagtt tcctttttgt tttcctttat 2580 aattcactaa aataaagcat ctattagtgt ctgatttagg aatgtaaaat gattctgtat 2640 taatgtaaat aagattatct attgcaaaaa gatatttcaa acctaaaaaa aaaaaaaaaa 2700 aaaa 2704 <210> 3 <211> 2150 <212> DNA <213> Homo sapiens <400> 3 agcttgacgg cgtcgggctg gagagccgca gtcccggctg cagcacctgg gagaaggcag 60 accgtgtgag ggggcctgtg gccccagcgt gctgtggcct ccgggagtgg gaagtggagg 120 caggagcctt ccttacactt cgccatgagt ttcctgatcg actccagcat catgattacc 180 tcccagatac tattttttgg atttgggtgg cttttcttca tgcgccaatt gtttaaagac 240 tatgagatac gtcagtatgt tgtacaggtg atcttctccg tgacgtttgc attttcttgc 300 accatgtttg agctcatcat ctttgaaatc ttaggagtat tgaatagcag ctcccgttat 360 tttcactgga aaatgaacct gtgtgtaatt ctgctgatcc tggttttcat ggtgcctttt 420 tacattggct attttattgt gagcaatatc cgactactgc ataaacaacg actgcttttt 480 tcctgtctct tatggctgac ctttatgtat ttcttctgga aactaggaga tccctttccc 540 attctcagcc caaaacatgg gatcttatcc atagaacagc tcatcagccg ggttggtgtg 600 attggagtga ctctcatggc tcttctttct ggatttggtg ctgtcaactg cccatacact 660 tacatgtctt acttcctcag gaatgtgact gacacggata ttctagccct ggaacggcga 720 ctgctgcaaa ccatggatat gatcataagc aaaaagaaaa ggatggcaat ggcacggaga 780 acaatgttcc agaaggggga agtgcataac aaaccatcag gtttctgggg aatgataaaa 840 agtgttacca cttcagcatc aggaagtgaa aatcttactc ttattcaaca ggaagtggat 900 gctttggaag aattaagcag gcagcttttt ctggaaacag ctgatctata tgctaccaag 960 gagagaatag aatactccaa aaccttcaag gggaaatatt ttaattttct tggttacttt 1020 ttctctattt actgtgtttg gaaaattttc atggctacca tcaatattgt ttttgatcga 1080 gttgggaaaa cggatcctgt cacaagaggc attgagatca ctgtgaatta tctgggaatc 1140 caatttgatg tgaagttttg gtcccaacac atttccttca ttcttgttgg aataatcatc 1200 gtcacatcca tcagaggatt gctgatcact cttaccaagt tcttttatgc catctctagc 1260 agtaagtcct ccaatgtcat tgtcctgcta ttagcacaga taatgggcat gtactttgtc 1320 tcctctgtgc tgctgatccg aatgagtatg cctttagaat accgcaccat aatcactgaa 1380 gtccttggag aactgcagtt caacttctat caccgttggt ttgatgtgat cttcctggtc 1440 agcgctctct ctagcatact cttcctctat ttggctcaca aacaggcacc agagaagcaa 1500 atggcacctt gaacttaagc ctactacaga ctgttagagg ccagtggttt caaaatttag 1560 atataagagg ggggaaaaat ggaaccaggg cctgacattt tataaacaaa caaaatgcta 1620 tggtagcatt tttcaccttc atagcatact ccttccccct caggtgatac tatgaccatg 1680 agtagcatca gccagaacat gagagggaga actaactcaa gacaatactc agcagagagc 1740 atcccgtgtg gatatgaggc tggtgtagag gcggagagga gccaagaaac taaaggtgaa 1800 aaatacactg gaactctggg gcaagagatg tctatggtag ctgagccaaa cacgtaggat 1860 ttccgtttta aggttcacat ggaaaaggtt atagctttgc cttgagattg actcattaaa 1920 atcagagact gtaacacttt tgccttacgt tcattttatc aagcatagct tggtatttat 1980 tatgcttgtg tgatctaaca tgagttagca tcccacacct cctcttctga tcctgcccca 2040 ttaaaataac caagaggtta tctgttcttt tccgggaaag gggtggtatg cacctgaaat 2100 agattttacc aaaagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2150 <210> 4 <211> 5855 <212> DNA <213> Homo sapiens <400> 4 agttgcctgc gcgccctcgc cggaccggcg gctccctagt tgcgccccga ccaggccctg 60 cccttgctgc cggctcgcgc gcgtccgcgc cccctccatt cctgggcgca tcccagctct 120 gccccaactc gggagtccag gcccgggcgc cagtgcccgc ttcagctccg gttcactgcg 180 cccgccggac gcgcgccgga ggactccgca gccctgctcc tgaccgtccc cccaggctta 240 acccggtcgc tccgctcgga ttcctcggct gcgctcgctc gggtggcgac ttcctccccg 300 cgccccctcc ccctcgccat gaagaagtcc attggaatat taagcccagg agttgctttg 360 gggatggctg gaagtgcaat gtcttccaag ttcttcctag tggctttggc catatttttc 420 tccttcgccc aggttgtaat tgaagccaat tcttggtggt cgctaggtat gaataaccct 480 gttcagatgt cagaagtata tattatagga gcacagcctc tctgcagcca actggcagga 540 ctttctcaag gacagaagaa actgtgccac ttgtatcagg accacatgca gtacatcgga 600 gaaggcgcga agacaggcat caaagaatgc cagtatcaat tccgacatcg aaggtggaac 660 tgcagcactg tggataacac ctctgttttt ggcagggtga tgcagatagg cagccgcgag 720 acggccttca catacgcggt gagcgcagca ggggtggtga acgccatgag ccgggcgtgc 780 cgcgagggcg agctgtccac ctgcggctgc agccgcgccg cgcgccccaa ggacctgccg 840 cgggactggc tctggggcgg ctgcggcgac aacatcgact atggctaccg ctttgccaag 900 gagttcgtgg acgcccgcga gcgggagcgc atccacgcca agggctccta cgagagtgct 960 cgcatcctca tgaacctgca caacaacgag gccggccgca ggacggtgta caacctggct 1020 gatgtggcct gcaagtgcca tggggtgtcc ggctcatgta gcctgaagac atgctggctg 1080 cagctggcag acttccgcaa ggtgggtgat gccctgaagg agaagtacga cagcgcggcg 1140 gccatgcggc tcaacagccg gggcaagttg gtacaggtca acagccgctt caactcgccc 1200 accacacaag acctggtcta catcgacccc agccctgact actgcgtgcg caatgagagc 1260 accggctcgc tgggcacgca gggccgcctg tgcaacaaga cgtcggaggg catggatggc 1320 tgcgagctca tgtgctgcgg ccgtggctac gaccagttca agaccgtgca gacggagcgc 1380 tgccactgca agttccactg gtgctgctac gtcaagtgca agaagtgcac ggagatcgtg 1440 gaccagtttg tgtgcaagta gtgggtgcca cccagcactc agccccgctc ccaggacccg 1500 cttatttata gaaagtacag tgattctggt ttttggtttt tagaaatatt ttttattttt 1560 ccccaagaat tgcaaccgga accatttttt ttcctgttac catctaagaa ctctgtggtt 1620 tattattaat attataatta ttatttggca ataatggggg tgggaaccaa gaaaaatatt 1680 tattttgtgg atctttgaaa aggtaataca agacttcttt tgatagtata gaatgaaggg 1740 gaaataacac ataccctaac ttagctgtgt ggacatggta cacatccaga aggtaaagaa 1800 atacattttc tttttctcaa atatgccatc atatgggatg ggtaggttcc agttgaaaga 1860 gggtggtaga aatctattca caattcagct tctatgacca aaatgagttg taaattctct 1920 ggtgcaagat aaaaggtctt gggaaaacaa aacaaaacaa aacaaacctc ccttccccag 1980 cagggctgct agcttgcttt ctgcattttc aaaatgataa tttacaatgg aaggacaaga 2040 atgtcatatt ctcaaggaaa aaaggtatat cacatgtctc attctcctca aatattccat 2100 ttgcagacag accgtcatat tctaatagct catgaaattt gggcagcagg gaggaaagtc 2160 cccagaaatt aaaaaattta aaactcttat gtcaagatgt tgatttgaag ctgttataag 2220 aattaggatt ccagattgta aaaagatccc caaatgattc tggacactag atttttttgt 2280 ttggggaggt tggcttgaac ataaatgaaa atatcctgtt attttcttag ggatacttgg 2340 ttagtaaatt ataatagtaa aaataataca tgaatcccat tcacaggttc tcagcccaag 2400 caacaaggta attgcgtgcc attcagcact gcaccagagc agacaaccta tttgaggaaa 2460 aacagtgaaa tccaccttcc tcttcacact gagccctctc tgattcctcc gtgttgtgat 2520 gtgatgctgg ccacgtttcc aaacggcagc tccactgggt cccctttggt tgtaggacag 2580 gaaatgaaac attaggagct ctgcttggaa aacagttcac tacttaggga tttttgtttc 2640 ctaaaacttt tattttgagg agcagtagtt ttctatgttt taatgacaga acttggctaa 2700 tggaattcac agaggtgttg cagcgtatca ctgttatgat cctgtgttta gattatccac 2760 tcatgcttct cctattgtac tgcaggtgta ccttaaaact gttcccagtg tacttgaaca 2820 gttgcattta taagggggga aatgtggttt aatggtgcct gatatctcaa agtcttttgt 2880 acataacata tatatatata tacatatata taaatataaa tataaatata tctcattgca 2940 gccagtgatt tagatttaca gtttactctg gggttatttc tctgtctaga gcattgttgt 3000 ccttcactgc agtccagttg ggattattcc aaaagttttt tgagtcttga gcttgggctg 3060 tggccctgct gtgatcatac cttgagcacg acgaagcaac cttgtttctg aggaagcttg 3120 agttctgact cactgaaatg cgtgttgggt tgaagatatc ttttttcttt tctgcctcac 3180 ccctttgtct ccaacctcca tttctgttca ctttgtggag agggcattac ttgttcgtta 3240 tagacatgga cgttaagaga tattcaaaac tcagaagcat cagcaatgtt tctcttttct 3300 tagttcattc tgcagaatgg aaacccatgc ctattagaaa tgacagtact tattaattga 3360 gtccctaagg aatattcagc ccactacata gatagctttt tttttttttt ttttaataag 3420 gacacctctt tccaaacagt gccatcaaat atgttcttat ctcagactta cgttgtttta 3480 aaagtttgga aagatacaca tctttcatac cccccttagg caggttggct ttcatatcac 3540 ctcagccaac tgtggctctt aatttattgc ataatgatat tcacatcccc tcagttgcag 3600 tgaattgtga gcaaaagatc ttgaaagcaa aaagcactaa ttagtttaaa atgtcacttt 3660 tttggttttt attatacaaa aaccatgaag tacttttttt atttgctaaa tcagattgtt 3720 cctttttagt gactcatgtt tatgaagaga gttgagttta acaatcctag cttttaaaag 3780 aaactattta atgtaaaata ttctacatgt cattcagata ttatgtatat cttctagcct 3840 ttattctgta cttttaatgt acatatttct gtcttgcgtg atttgtatat ttcactggtt 3900 taaaaaacaa acatcgaaag gcttatgcca aatggaagat agaatataaa ataaaacgtt 3960 acttgtatat tggtaagtgg tttcaattgt ccttcagata attcatgtgg agatttttgg 4020 agaaaccatg acggatagtt taggatgact acatgtcaaa gtaataaaag agtggtgaat 4080 tttaccaaaa ccaagctatt tggaagcttc aaaaggtttc tatatgtaat ggaacaaaag 4140 gggaattctc ttttcctata tatgttcctt acaaaaaaaa aaaaaaaaga aatcaagcag 4200 atggcttaaa gctggttata ggattgctca cattctttta gcattatgca tgtaacttaa 4260 ttgttttaga gcgtgttgct gttgtaacat cccagagaag aatgaaaagg cacatgcttt 4320 tatccgtgac cagattttta gtccaaaaaa atgtattttt ttgtgtgttt accactgcaa 4380 ctattgcacc tctctatttg aatttactgt ggaccatgtg tggtgtctct atgccctttg 4440 aaagcagttt ttataaaaag aaagcccggg tctgcagaga atgaaaactg gttggaaact 4500 aaaggttcat tgtgttaagt gcaattaata caagttattg tgcttttcaa aaatgtacac 4560 ggaaatctgg acagtgctgc acagattgat acattagcct ttgctttttc tctttccgga 4620 taaccttgta acatattgaa accttttaag gatgccaaga atgcattatt ccacaaaaaa 4680 acagcagacc aacatataga gtgtttaaaa tagcatttct gggcaaattc aaactcttgt 4740 ggttctagga ctcacatctg tttcagtttt tcctcagttg tatattgacc agtgttcttt 4800 attgcaaaaa catatacccg atttagcagt gtcagcgtat tttttcttct catcctggag 4860 cgtattcaag atcttcccaa tacaagaaaa ttaataaaaa atttatatat aggcagcagc 4920 aaaagagcca tgttcaaaat agtcattatg ggctcaaata gaaagaagac ttttaagttt 4980 taatccagtt tatctgttga gttctgtgag ctactgacct cctgagactg gcactgtgta 5040 agttttagtt gcctacccta gctcttttct cgtacaattt tgccaatacc aagtttcaat 5100 ttgtttttac aaaacattat tcaagccact agaattatca aatatgacgc tatagcagag 5160 taaatactct gaataagaga ccggtactag ctaactccaa gagatcgtta gcagcatcag 5220 tccacaaaca cttagtggcc cacaatatat agagagatag aaaaggtagt tataacttga 5280 agcatgtatt taatgcaaat aggcacgaag gcacaggtct aaaatactac attgtcactg 5340 taagctatac ttttaaaata tttatttttt ttaaagtatt ttctagtctt ttctctctct 5400 gtggaatggt gaaagagaga tgccgtgttt tgaaagtaag atgatgaaat gaatttttaa 5460 ttcaagaaac attcagaaac ataggaatta aaacttagag aaatgatcta atttccctgt 5520 tcacacaaac tttacacttt aatctgatga ttggatattt tattttagtg aaacatcatc 5580 ttgttagcta actttaaaaa atggatgtag aatgattaaa ggttggtatg attttttttt 5640 aatgtatcag tttgaaccta gaatattgaa ttaaaatgct gtctcagtat tttaaaagca 5700 aaaaaggaat ggaggaaaat tgcatcttag accattttta tatgcagtgt acaatttgct 5760 gggctagaaa tgagataaag attatttatt tttgttcata tcttgtactt ttctattaaa 5820 atcattttat gaaatccaaa aaaaaaaaaa aaaaa 5855 <210> 5 <211> 827 <212> DNA <213> Homo sapiens <400> 5 gtataaggtc cacaccccgg gagctgagtg attgcagaaa ctggccttcc atctctctca 60 gacaccaagc tgcagatcca ggcttttctg ggaaagtgag gccaccatgg ctctggagaa 120 gtctcttgtc cggctccttc tgcttgtcct gatactgctg gtgctgggct gggtccagcc 180 ttccctgggc aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag 240 ttcccccagc agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca 300 ggggcggtgc aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt 360 ctgtttccag gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc 420 cagcatgcac atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata 480 ccggaccagc ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc 540 agtccacttt gatgcttctg tggaggactc tacctaaggt cagagcagcg agatacccca 600 cctccctcaa cctcatcctc tccacagctg cctcttccct cttccttccc tgctgtgaaa 660 gaagtaacta cagttagggc tcctattcaa cacacacatg cttccctttc ctgagtccca 720 tccctgcgtg attttggggg tgaagagtgg gttgtgaggt gggccccatg ttaacccctc 780 cactctttct ttcaataaaa cgcagttgca aacacctgaa aaaaaaa 827 <210> 6 <211> 3593 <212> DNA <213> Homo sapiens <400> 6 ctcggccccg ggctgccgcg ccagcccgtc tccgcggcgg gggaccgggc tgccttggcc 60 cctcagcgct cgcgtctttt ccggcagttg gaacgcttcc tgttgtcctc acccgtaacc 120 gcctgttgcc ccctgtctca gagtccctca cgcgtcccct cccgtctttg gctcgttggc 180 tgccgccgcc ggggcttcgc cagccttcaa gtcgagacta ctggccgaag gggcgtctgc 240 ggctctccgc cgtccccagc cctgcctctc cctgggctct gcagccatgg caatgacagg 300 ctcaacacct tgctcatcca tgagtaacca cacaaaggaa agggtgacaa tgaccaaagt 360 gacactggag aatttttata gcaaccttat cgctcaacat gaagaacgag aaatgagaca 420 aaagaagtta gaaaaggtga tggaagaaga aggcctaaaa gatgaggaga aacgactccg 480 gagatcagca catgctcgga aggaaacaga gtttcttcgt ttgaagagaa caagacttgg 540 attggaagat tttgagtcct taaaagtaat aggcagagga gcatttggtg aggtacggct 600 tgttcagaag aaagatacgg gacatgtgta tgcaatgaaa atactccgta aagcagatat 660 gcttgaaaaa gagcaggttg gccacattcg tgcggagcgt gacattctag tggaggcaga 720 cagtttgtgg gttgtgaaaa tgttctatag ttttcaggat aagctaaacc tctacctaat 780 catggagttc ctgcctggag gggacatgat gaccttgttg atgaaaaaag acactctgac 840 agaagaggag actcagtttt atatagcaga aacagtatta gccatagact ctattcacca 900 acttggattc atccacagag acatcaaacc agacaacctt cttttggaca gcaagggcca 960 tgtgaaactt tctgactttg gtctttgcac aggactgaaa aaagcacata ggacagaatt 1020 ttataggaat ctgaaccaca gcctccccag tgatttcact ttccagaaca tgaattccaa 1080 aaggaaagca gaaacctgga aaagaaatag acgtcagcta gccttctcca cagtaggcac 1140 tcctgactac attgctcctg aggtgttcat gcagaccggg tacaacaagc tctgtgattg 1200 gtggtcgctt ggggtgatca tgtatgagat gctcatcggc tacccacctt tctgttctga 1260 gacccctcaa gagacatata agaaggtgat gaactggaaa gaaactttga cttttcctcc 1320 agaagttccc atctctgaga aagccaagga tctaattttg aggttctgct gtgaatggga 1380 acatagaatt ggagctcctg gagttgagga aataaaaagt aactcttttt ttgaaggcgt 1440 tgactgggaa catatcagag agagacctgc tgcaatatct attgaaatca aaagcattga 1500 tgatacctca aacttcgatg agtttccaga atctgatatt cttaagccaa cagtggccac 1560 aagtaatcat cctgagactg actacaagaa caaagactgg gtcttcatca attacacgta 1620 caagcgcttt gagggcctga ctgcaagggg ggcaatacct tcctacatga aagcagcaaa 1680 atagtactct tgccacggaa tcctatgtgg agcagagttc tttgtataac atcatgcttt 1740 tcctctcaca ctcttgaaga gcttccaaga agttgatgga acccaccaat atgtcatagt 1800 aaagtctcct gaaatgtggt agtaagagga ttttcttcca taatgcatct gaaaaactgt 1860 aaacaaagac aaccatttct actacgtcgg ccataaacag ctatcctgct ttggaagaga 1920 agcatcatga gccaatttga taggtgtttt aaaaataact tgagttttcc taagttcatc 1980 agaatgaagg ggaaaaacag ccatcatcca acattattga gattgtcgtg tatagtcatc 2040 gaatatcagc cagttcctgt aattttgtga cacgctctct gccaagccca ccaagtattt 2100 cctttatagc taaaagttcc atagtactaa ggaaataaag caataaagac agtctcagca 2160 gccaggattc tggctgaagg aaatgatccg ccaccctgag ggtggtgatg gtagtttcta 2220 cccatacctc agcctcaggc gagtggctta tagcctccat tcatggtgca ctttatttat 2280 ggtactaaga taaagactgt caatccattg atttatctcc tcctgtcccc catctaaaat 2340 acccatgctg cttttctgag tgttgatggg ggttaccagc ttgatccact gttgctctta 2400 gaaggcccag aaagtctttg ggcattgcca agaaatcccg gattatgtgg aaaaccctca 2460 ctttctcttc acggctgtac cagaaaatcc ctaagacaga tcttgccgtg gactagcaat 2520 acctgcaagt gctgccaatg ggaactcaat ttattcctgg gaacctaacg aggagagccc 2580 aggcctaggc aggaggcctg gaaccctctt ggctaaggtg ctgttcctgt tcctgcaagg 2640 tctccagaac ccctttggaa atggtgaagg aaccagccca atagaagtac agagccagct 2700 gacaagtcct tgtaaagctc actcctcagt ccttggcaca gccatgtttt gtcttctctc 2760 ttggtatttc ttctctccca actttagcca ttttgccttg gaatcatgat tacaattttt 2820 tcctttgcag atgccttcct gggggatact cctccccacc ctaaagggtc gcctgcaact 2880 taggcggatt gggtctctct gctgtggcgt tctctcttga gagaccctct gaattttagc 2940 acaaagtgcc ttctgtttca cagctgccac cacctttaga ggaatttcgt cagaaaaatg 3000 tggaggctcc atattaatgc attatttttt aaaaagtttt gataactctt aaagcatcat 3060 ttgcacctat gtgggaactt tgcctgttgc aaagtattgt ggccgagctg cagctgggag 3120 cctgctttct gccagtcttg aggttctgaa gatcagcttt gaaaggaaag tatgtcctag 3180 cttagccatt cagaagagaa aaatggaata tcagagttac agttgtcagt gaaactactt 3240 tggattttaa cctcttagag gaagaaaaaa ggttagggaa gtgtcaactc tggatgaagg 3300 tgatgtgttt gcctctcagt ctttcattca tagcctgcta gtgaaaagga agtaaatgag 3360 attcttttgt gtgactttgt agtctctttg tattaccaaa tagttggggt gttgactcct 3420 gtgtgttttg caagaatgtg tggtaagcct gggtaaagag aaggaactgc ggtgttggga 3480 gagtctttgt gttggggagt ggcaggggat gatttgtttc aggggaaaat gcccacattt 3540 taacttttaa acttctgaat aaactgtgta aaaacaaaaa aaaaaaaaaa aaa 3593 <210> 7 <211> 865 <212> DNA <213> Homo sapiens <400> 7 ctcaaacacc gcctgctaaa aatacccgac tggaggagca taaaagcgca gccgagccca 60 gcgccccgca cttttctgag cagacgtcca gagcagagtc agccagcatg accgagcgcc 120 gcgtcccctt ctcgctcctg cggggcccca gctgggaccc cttccgcgac tggtacccgc 180 atagccgcct cttcgaccag gccttcgggc tgccccggct gccggaggag tggtcgcagt 240 ggttaggcgg cagcagctgg ccaggctacg tgcgccccct gccccccgcc gccatcgaga 300 gccccgcagt ggccgcgccc gcctacagcc gcgcgctcag ccggcaactc agcagcgggg 360 tctcggagat ccggcacact gcggaccgct ggcgcgtgtc cctggatgtc aaccacttcg 420 ccccggacga gctgacggtc aagaccaagg atggcgtggt ggagatcacc ggcaagcacg 480 aggagcggca ggacgagcat ggctacatct cccggtgctt cacgcggaaa tacacgctgc 540 cccccggtgt ggaccccacc caagtttcct cctccctgtc ccctgagggc acactgaccg 600 tggaggcccc catgcccaag ctagccacgc agtccaacga gatcaccatc ccagtcacct 660 tcgagtcgcg ggcccagctt gggggcccag aagctgcaaa atccgatgag actgccgcca 720 agtaaagcct tagcctggat gcccacccct gctgccgcca ctggctgtgc ctcccccgcc 780 acctgtgtgt tcttttgata catttatctt ctgtttttct caaataaagt tcaaagcaac 840 cacctgtaaa aaaaaaaaaa aaaaa 865 <210> 8 <211> 1749 <212> DNA <213> Homo sapiens <400> 8 ccaaaagtgc ctctgataac agcaaagcag aggagaccca aggaaatgtg gatgaggctt 60 cattgaaaga atcatcaccg agtgatgact ccatcatttc accacttagt gaagactccc 120 aagctgaagc agagggtgtg ttcgtgtctc caaacaaacc tcgaacaact gaggatttat 180 ttgcagtcat tcacagatcc aagaggaaag tacttggaag aaaagattcc ggggacatgt 240 ctgttcgaag caaatcgaga gctcccctca gcagtagcag cagcagcgcc agttccatca 300 cttcacccag cagtaatgtg acaaccccca acagccagag gtctcctggt ctcatatacc 360 gaaatgccaa aaagtccaac acatccaatg aagagtttaa gctgttactg ctcaagaaag 420 gcagtcgctc agattctagt taccgcatgt ctgccactga gatcctgaag agccccatac 480 tgcccaaacc tcctggggag ctcacagcag agtcccctca gagcaccgat gatgcccatc 540 aggggtcaca aggggctgag gcattgtccc cactctctcc atgctcccca cgagttaatg 600 cagaaggctt ttcctcgaag agctttgcca cctcagcatc agcaagggtt ggacgttctc 660 gggcccctcc tgcagccagc agcagccgct acagtgtccg ctgccggctg tacaatacgc 720 ccatgcaggc aatctccgag ggagagacgg aaaattctga cgggagccca catgacgacc 780 gttcctccca gagttcaaca tagactgcct gtaccaggct gcctggcaaa ggccaaaacc 840 cttactcaca tgaggatgga ggaacagaac agaggacttg ggaaaagtct caacttgatg 900 gggtagcatc actgctaagc aatgaatgaa tttctaaata cagtatgtgc tgggtaaaca 960 gaaagtggtt tagacattct tgattagttt ccatatttta agtagctgca gtctttatta 1020 ctgcaggaaa aggtcccgga gagctgagca gtcaagatgt gtgacttcac cgaagaccag 1080 accgcagagt tcaaggaggc cttccagctg tttgaccgaa caggtgatgg caagatcctg 1140 tacagccagt gtggggatgt gatgagggcc ctgggccaga accctaccaa cgccgaggtg 1200 ctcaaggtcc tggggaaccc caagagtgat gagatgaatg tgaaggtgct ggactttgag 1260 cactttctgc ccatgctgca gacagtggcc aagaacaagg accagggcac ctatgaggat 1320 tatgtcgaag gacttcgggt gtttgacaag gaaggaaatg gcaccgtcat gggtgctgaa 1380 atccggcatg ttcttgtcac actgggtgag aagatgacag aggaagaagt agagatgctg 1440 gtggcagggc atgaggacag caatggttgt atcaactatg aagagctcgt ccgcatggtg 1500 ctgaatggct gaggaccttc ccagtctccc cagagtccgt gcctttccct gtgtgaattt 1560 tgtatctagc ctaaagtttc cctaggcttt cttgtctcag caactttccc atcttgtctc 1620 tcttggatga tgtttgccgt cagcattcac caaataaact tgctctctgg gaaaaaaaaa 1680 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1740 aaaaaaaaa 1749 <210> 9 <211> 586 <212> DNA <213> Homo sapiens <400> 9 agttaaaagg gtgggagcgt ccgggggccc atctctctcg ggtggagtct tctgacagct 60 ggtgcgcctg cccgggaaca tcctcctgga ctcaatcatg gcttgtggtc tggtcgccag 120 caacctgaat ctcaaacctg gagagtgcct tcgagtgcga ggcgaggtgg ctcctgacgc 180 taagagcttc gtgctgaacc tgggcaaaga cagcaacaac ctgtgcctgc acttcaaccc 240 tcgcttcaac gcccacggcg acgccaacac catcgtgtgc aacagcaagg acggcggggc 300 ctgggggacc gagcagcggg aggctgtctt tcccttccag cctggaagtg ttgcagaggt 360 gtgcatcacc ttcgaccagg ccaacctgac cgtcaagctg ccagatggat acgaattcaa 420 gttccccaac cgcctcaacc tggaggccat caactacatg gcagctgacg gtgacttcaa 480 gatcaaatgt gtggcctttg actgaaatca gccagcccat ggcccccaat aaaggcagct 540 gcctctgctc cctctgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 586 <210> 10 <211> 272 <212> DNA <213> Homo sapiens <400> 10 tttttttttt tttttttcag agttttatca tctttatttt caatttgcta gaccaggttg 60 ctttcccctg tatgagggag tgccaatctc tgattgctgg gtaccaaacc acatcctggc 120 ctgtgtgggg taccatggag gaaggagata agacccagac ccctggcagc tcccagttta 180 gcaggggaga caagacaaca catgaaaaca aacagagcac atcaaaaagg caacaggtca 240 aaccaatgca gggaaacccc tatcattaaa gg 272 <210> 11 <211> 670 <212> DNA <213> Homo sapiens <400> 11 atttggatcg gggtacagag gatctccctg aacatcatga ggaatctggt caaggcccct 60 cagcagaagg cagaacagaa ccgagttcct ttaaatgctg gtttttgtgt ggagtgagga 120 aggaccgtga gtgtggtcag tttccaacct gacaggacct gctcccgttg gccaggactg 180 cagcttgtta ctttgaccct gggaagaagg tccatcccga cggcgcgtgt gccgcttggc 240 tcaaggccct gacatcgttc cactcagcac agcatcaggt gcccgggacc ctggacatca 300 tcgttctgtg tcagcacatc aggtgcccgg ggcccggaca tcatcgttcc actcagcaca 360 gcatcaggtg cctgggaccc tggacatcat cgttccactc agcacagcat caggtgcctg 420 ggaccctgga catcatcgtt ctgctcagca cagcatcagg tgcccgggac cctggacgtc 480 attctgcatc agcacaacat caccagtgac gagagcctcc ccaagtggtt gacgggaagg 540 atggttcggt cctccagagg cggtggcctt ctcttcctcg atgacattgc cgggctgcac 600 cttgtgagag gccgtcgctg agagtgcagc caaatggaac catcaggagg ggtgtctcgg 660 gggtgtcgaa 670 <210> 12 <211> 3220 <212> DNA <213> Homo sapiens <400> 12 cagtggagtc ccagttgaag agacaaaaaa acagaagctg tcggaatgca gtctaaccaa 60 aggtcaagat gggctacaga atgactttct gtccatcagt gaagacgtgc ctcggcctcc 120 tgacactgtc agtactggga aaggtggaaa gaattctgag gctcagttgg aagatgagga 180 agaagaggag gaagatggac tttcagagga gtgcgaggag gaggaatcag agagttttgc 240 agacatgatg aagcatggac tcactgaggc tgacgtaggc atcaccaagt ttgtgagttc 300 tcatcaaggg ttctcgggaa tcttaaaaga aagatactcc gacttcgttg ttcatgaaat 360 aggaaaagat ggacggatca gccatttgaa tgacttgtcc attccagtgg atgaggagga 420 cccttcagaa gacatattta cagttttgac agctgaagaa aagcagcgat tggaagagct 480 ccagctgttc aaaaataagg aaaccagtgt tgccattgag gttatcgagg acaccaaaga 540 gaaaagaacc atcatccatc aggctatcaa atctctgttt ccaggattag agacaaaaac 600 agaggatagg gaggggaaga aatacattgt agcctaccac gcagctggga aaaaggcttt 660 ggcaaaggtc agaactgcag cagatccaag aaaacattct tggccaaaat ctaggggaag 720 ttactgccac ttcgtactat ataaggaaaa caaagacacc atggatgcta ttaatgtact 780 ctccaaatac ttaagagtca agccaaatat attctcctac atgggaacca aagataaaag 840 ggctataaca gttcaagaaa ttgctgttct caaaataact gcacaaagac ttgcccacct 900 gaataagtgc ttgatgaact ttaagctagg gaatttcagc tatcaaaaaa acccactgaa 960 attgggagag cttcaaggaa accacttcac tgttgttctc agaaatataa caggaactga 1020 tgaccaagta cagcaagcta tgaactctct caaggagatt ggatttatta actactatgg 1080 aatgcaaaga tttggaacca cagctgtccc tacgtatcag gttggaagag ctatactaca 1140 aaattcctgg acagaagtca tggatttaat attgaaaccc cgctctggag ctgaaaaggg 1200 ctacttggtt aaatgcagag aagaatgggc aaagaccaaa gacccaactg ctgccctcag 1260 aaaactacct gtcaaaaggt gtgtggaagg gcagctgctt cgaggacttt caaaatatgg 1320 aatgaagaat atagtctctg catttggcat aatacccaga aataatcgct taatgtatat 1380 tcatagctac caaagctatg tgtggaataa catggtaagc aagaggatag aagactatgg 1440 actaaaacct gttccagggg acctcgttct caaaggagcc acagccacct atattgagga 1500 agatgatgtt aataattact ctatccatga tgtggtaatg cccttgcctg gtttcgatgt 1560 tatctaccca aagcataaaa ttcaagaagc ctacagggaa atgctcacag ctgacaatct 1620 tgatattgac aacatgagac acaaaattcg agattattcc ttgtcagggg cctaccgaaa 1680 gatcattatt cgtcctcaga atgttagctg ggaagtcgtt gcatatgatg atcccaaaat 1740 tccacttttc aacacagatg tggacaacct agaagggaag acaccaccag tttttgcttc 1800 tgaaggcaaa tacagggctc tgaaaatgga tttttctcta cccccttcta cttacgccac 1860 catggccatt cgagaagtgc taaaaatgga taccagtatc aagaaccaga cgcagctgaa 1920 tacaacctgg cttcgctgag cagtaccttg tccacagatt agaaaacgta cacaagtgtt 1980 tgcttcctgg ctccctgtgc atttttgtct tagttcagac tcatatatgg atttcaaatc 2040 tttgtaataa aaattatttg tatttttaag tttttattag cttaaagaaa taatttgcaa 2100 tatttgtaca tgtacacaaa tcctgaggtt cttaatttta gctcagaata taaattagtc 2160 aaaatacact tcaggtgctt aaatcagagt aaaatgtcag ctttacaata ataaaaaaag 2220 gactttggtt taaagtagca ggtttaggtt ttgctacatt ctcaaaagac agcaggagta 2280 tttgacacat ctgtgatgga gtatacaaca atgcatttta agagcaaatg caacaaaaca 2340 aatctggact atggataaat aatttgagag ctgccaccca caaatataaa tacagtactc 2400 atgctgactg aaataataag acatctacaa atttataaac aaaaagtgat tgtcattatc 2460 ctgcttatgt actagattca ggcaagcatt atagactttt tggttgcggt ggcttttgca 2520 tttatattat caatgccttg caggaacgtt gcattgatag gcccatttta tttttttatt 2580 ttttttttcg agacaggatc tcactctgta gcacaggctg gattgcagtg caatcctgca 2640 attctcaatc ttgcactgca gcctcgacct cccaggctcc agtgactctc ccacctcagc 2700 ctcctaagta gctgggagta caggcgcgca ccaccacgcc tagctgattt ttgtattttt 2760 ttgtagagac gggggtttgg ccatgttgcc gaggctaact cctgggatta caggcatgag 2820 ctgtgctggc cgggtttttt tttcttgatg taaacgtgta cagctgtttt attagttaag 2880 gtctaatttt tactctaggt gccttttatg ttcagaactc tttccactgg actggtattt 2940 gctcaaaaat aaataatggt agagaagaaa actataaaaa tggacaaggc tttcttctat 3000 cagtagcgtt taccctttgt caccagtggc tttggtattt ccatgtctgg cattgcataa 3060 acttctctgg tgtgaaagga taaatatgcc tttctaaagt tgtatatcaa aattgtatca 3120 atttttattt tctatgattt ctagaaacaa atgtaataaa tatttttaaa atctcctttc 3180 tactggttat gtaaataaat caaataaata tatcaaaatg 3220 <210> 13 <211> 13509 <212> DNA <213> Homo sapiens <400> 13 ggggcatttc cgggtccggg ccgagcgggc gcacgcgcgg gagcgggact cggcggcatg 60 gcgggctccg gagccggtgt gcgttgctcc ctgctgcggc tgcaggagac cttgtccgct 120 gcggaccgct gcggtgctgc cctggccggt catcaactga tccgcggcct ggggcaggaa 180 tgcgtcctga gcagcagccc cgcggtgctg gcattacaga catctttagt tttttccaga 240 gatttcggtt tgcttgtatt tgtccggaag tcactcaaca gtattgaatt tcgtgaatgt 300 agagaagaaa tcctaaagtt tttatgtatt ttcttagaaa aaatgggcca gaagatcgca 360 ccttactctg ttgaaattaa gaacacttgt accagtgttt atacaaaaga tagagctgct 420 aaatgtaaaa ttccagccct ggaccttctt attaagttac ttcagacttt tagaagttct 480 agactcatgg atgaatttaa aattggagaa ttatttagta aattctatgg agaacttgca 540 ttgaaaaaaa aaataccaga tacagtttta gaaaaagtat atgagctcct aggattattg 600 ggtgaagttc atcctagtga gatgataaat aatgcagaaa acctgttccg cgcttttctg 660 ggtgaactta agacccagat gacatcagca gtaagagagc ccaaactacc tgttctggca 720 ggatgtctga aggggttgtc ctcacttctg tgcaacttca ctaagtccat ggaagaagat 780 ccccagactt caagggagat ttttaatttt gtactaaagg caattcgtcc tcagattgat 840 ctgaagagat atgctgtgcc ctcagctggc ttgcgcctat ttgccctgca tgcatctcag 900 tttagcacct gccttctgga caactacgtg tctctatttg aagtcttgtt aaagtggtgt 960 gcccacacaa atgtagaatt gaaaaaagct gcactttcag ccctggaatc ctttctgaaa 1020 caggtttcta atatggtggc gaaaaatgca gaaatgcata aaaataaact gcagtacttt 1080 atggagcagt tttatggaat catcagaaat gtggattcga acaacaagga gttatctatt 1140 gctatccgtg gatatggact ttttgcagga ccgtgcaagg ttataaacgc aaaagatgtt 1200 gacttcatgt acgttgagct cattcagcgc tgcaagcaga tgttcctcac ccagacagac 1260 actggtgacg accgtgttta tcagatgcca agcttcctcc agtctgttgc aagcgtcttg 1320 ctgtaccttg acacagttcc tgaggtgtat actccagttc tggagcacct cgtggtgatg 1380 cagatagaca gtttcccaca gtacagtcca aaaatgcagc tggtgtgttg cagagccata 1440 gtgaaggtgt tcctagcttt ggcagcaaaa gggccagttc tcaggaattg cattagtact 1500 gtggtgcatc agggtttaat cagaatatgt tctaaaccag tggtccttcc aaagggccct 1560 gagtctgaat ctgaagacca ccgtgcttca ggggaagtca gaactggcaa atggaaggtg 1620 cccacataca aagactacgt ggatctcttc agacatctcc tgagctctga ccagatgatg 1680 gattctattt tagcagatga agcatttttc tctgtgaatt cctccagtga aagtctgaat 1740 catttacttt atgatgaatt tgtaaaatcc gttttgaaga ttgttgagaa attggatctt 1800 acacttgaaa tacagactgt tggggaacaa gagaatggag atgaggcgcc tggtgtttgg 1860 atgatcccaa cttcagatcc agcggctaac ttgcatccag ctaaacctaa agatttttcg 1920 gctttcatta acctggtgga attttgcaga gagattctcc ctgagaaaca agcagaattt 1980 tttgaaccat gggtgtactc attttcatat gaattaattt tgcaatctac aaggttgccc 2040 ctcatcagtg gtttctacaa attgctttct attacagtaa gaaatgccaa gaaaataaaa 2100 tatttcgagg gagttagtcc aaagagtctg aaacactctc ctgaagaccc agaaaagtat 2160 tcttgctttg ctttatttgt gaaatttggc aaagaggtgg cagttaaaat gaagcagtac 2220 aaagatgaac ttttggcctc ttgtttgacc tttcttctgt ccttgccaca caacatcatt 2280 gaactcgatg ttagagccta cgttcctgca ctgcagatgg ctttcaaact gggcctgagc 2340 tataccccct tggcagaagt aggcctgaat gctctagaag aatggtcaat ttatattgac 2400 agacatgtaa tgcagcctta ttacaaagac attctcccct gcctggatgg atacctgaag 2460 acttcagcct tgtcagatga gaccaagaat aactgggaag tgtcagctct ttctcgggct 2520 gcccagaaag gatttaataa agtggtgtta aagcatctga agaagacaaa gaacctttca 2580 tcaaacgaag caatatcctt agaagaaata agaattagag tagtacaaat gcttggatct 2640 ctaggaggac aaataaacaa aaatcttctg acagtcacgt cctcagatga gatgatgaag 2700 agctatgtgg cctgggacag agagaagcgg ctgagctttg cagtgccctt tagagagatg 2760 aaacctgtca ttttcctgga tgtgttcctg cctcgagtca cagaattagc gctcacagcc 2820 agtgacagac aaactaaagt tgcagcctgt gaacttttac atagcatggt tatgtttatg 2880 ttgggcaaag ccacgcagat gccagaaggg ggacagggag ccccacccat gtaccagctc 2940 tataagcgga cgtttcctgt gctgcttcga cttgcgtgtg atgttgatca ggtgacaagg 3000 caactgtatg agccactagt tatgcagctg attcactggt tcactaacaa caagaaattt 3060 gaaagtcagg atactgttgc cttactagaa gctatattgg atggaattgt ggaccctgtt 3120 gacagtactt taagagattt ttgtggtcgg tgtattcgag aattccttaa atggtccatt 3180 aagcaaataa caccacagca gcaggagaag agtccagtaa acaccaaatc gcttttcaag 3240 cgactttata gccttgcgct tcaccccaat gctttcaaga ggctgggagc atcacttgcc 3300 tttaataata tctacaggga attcagggaa gaagagtctc tggtggaaca gtttgtgttt 3360 gaagccttgg tgatatacat ggagagtctg gccttagcac atgcagatga gaagtcctta 3420 ggtacaattc aacagtgttg tgatgccatt gatcacctat gccgcatcat tgaaaagaag 3480 catgtttctt taaataaagc aaagaaacga cgtttgccgc gaggatttcc accttccgca 3540 tcattgtgtt tattggatct ggtcaagtgg cttttagctc attgtgggag gccccagaca 3600 gaatgtcgac acaaatccat tgaactcttt tataaattcg ttcctttatt gccaggcaac 3660 agatccccta atttgtggct gaaagatgtt ctcaaggaag aaggtgtctc ttttctcatc 3720 aacacctttg aggggggtgg ctgtggccag ccctcgggca tcctggccca gcccaccctc 3780 ttgtaccttc gggggccatt cagcctgcag gccacgctat gctggctgga cctgctcctg 3840 gccgcgttgg agtgctacaa cacgttcatt ggcgagagaa ctgtaggagc gctccaggtc 3900 ctaggtactg aagcccagtc ttcacttttg aaagcagtgg ctttcttctt agaaagcatt 3960 gccatgcatg acattatagc agcagaaaag tgctttggca ctggggcagc aggtaacaga 4020 acaagcccac aagagggaga aaggtacaac tacagcaaat gcaccgttgt ggtccggatt 4080 atggagttta ccacgactct gctaaacacc tccccggaag gatggaagct cctgaagaag 4140 gacttgtgta atacacacct gatgagagtc ctggtgcaga cgctgtgtga gcccgcaagc 4200 ataggtttca acatcggaga cgtccaggtt atggctcatc ttcctgatgt ttgtgtgaat 4260 ctgatgaaag ctctaaagat gtccccatac aaagatatcc tagagaccca tctgagagag 4320 aaaataacag cacagagcat tgaggagctt tgtgccgtca acttgtatgg ccctgacgcg 4380 caagtggaca ggagcaggct ggctgctgtt gtgtctgcct gtaaacagct tcacagagct 4440 gggcttctgc ataatatatt accgtctcag tccacagatt tgcatcattc tgttggcaca 4500 gaacttcttt ccctggttta taaaggcatt gcccctggag atgagagaca gtgtctgcct 4560 tctctagacc tcagttgtaa gcagctggcc agcggacttc tggagttagc ctttgctttt 4620 ggaggactgt gtgagcgcct tgtgagtctt ctcctgaacc cagcggtgct gtccacggcg 4680 tccttgggca gctcacaggg cagcgtcatc cacttctccc atggggagta tttctatagc 4740 ttgttctcag aaacgatcaa cacggaatta ttgaaaaatc tggatcttgc tgtattggag 4800 ctcatgcagt cttcagtgga taataccaaa atggtgagtg ccgttttgaa cggcatgtta 4860 gaccagagct tcagggagcg agcaaaccag aaacaccaag gactgaaact tgcgactaca 4920 attctgcaac actggaagaa gtgtgattca tggtgggcca aagattcccc tctcgaaact 4980 aaaatggcag tgctggcctt actggcaaaa attttacaga ttgattcatc tgtatctttt 5040 aatacaagtc atggttcatt ccctgaagtc tttacaacat atattagtct acttgctgac 5100 acaaagctgg atctacattt aaagggccaa gctgtcactc ttcttccatt cttcaccagc 5160 ctcactggag gcagtctgga ggaacttaga cgtgttctgg agcagctcat cgttgctcac 5220 ttccccatgc agtccaggga atttcctcca ggaactccgc ggttcaataa ttatgtggac 5280 tgcatgaaaa agtttctaga tgcattggaa ttatctcaaa gccctatgtt gttggaattg 5340 atgacagaag ttctttgtcg ggaacagcag catgtcatgg aagaattatt tcaatccagt 5400 ttcaggagga ttgccagaag gggttcatgt gtcacacaag taggccttct ggaaagcgtg 5460 tatgaaatgt tcaggaagga tgacccccgc ctaagtttca cacgccagtc ctttgtggac 5520 cgctccctcc tcactctgct gtggcactgt agcctggatg ctttgagaga attcttcagc 5580 acaattgtgg tggatgccat tgatgtgttg aagtccaggt ttacaaagct aaatgaatct 5640 acctttgata ctcaaatcac caagaagatg ggctactata agattctaga cgtgatgtat 5700 tctcgccttc ccaaagatga tgttcatgct aaggaatcaa aaattaatca agttttccat 5760 ggctcgtgta ttacagaagg aaatgaactt acaaagacat tgattaaatt gtgctacgat 5820 gcatttacag agaacatggc aggagagaat cagctgctgg agaggagaag actttaccat 5880 tgtgcagcat acaactgcgc catatctgtc atctgctgtg tcttcaatga gttaaaattt 5940 taccaaggtt ttctgtttag tgaaaaacca gaaaagaact tgcttatttt tgaaaatctg 6000 atcgacctga agcgccgcta taattttcct gtagaagttg aggttcctat ggaaagaaag 6060 aaaaagtaca ttgaaattag gaaagaagcc agagaagcag caaatgggga ttcagatggt 6120 ccttcctata tgtcttccct gtcatatttg gcagacagta ccctgagtga ggaaatgagt 6180 caatttgatt tctcaaccgg agttcagagc tattcataca gctcccaaga ccctagacct 6240 gccactggtc gttttcggag acgggagcag cgggacccca cggtgcatga tgatgtgctg 6300 gagctggaga tggacgagct caatcggcat gagtgcatgg cgcccctgac ggccctggtc 6360 aagcacatgc acagaagcct gggcccgcct caaggagaag aggattcagt gccaagagat 6420 cttccttctt ggatgaaatt cctccatggc aaactgggaa atccaatagt accattaaat 6480 atccgtctct tcttagccaa gcttgttatt aatacagaag aggtctttcg cccttacgcg 6540 aagcactggc ttagcccctt gctgcagctg gctgcttctg aaaacaatgg aggagaagga 6600 attcactaca tggtggttga gatagtggcc actattcttt catggacagg cttggccact 6660 ccaacagggg tccctaaaga tgaagtgtta gcaaatcgat tgcttaattt cctaatgaaa 6720 catgtctttc atccaaaaag agctgtgttt agacacaacc ttgaaattat aaagaccctt 6780 gtcgagtgct ggaaggattg tttatccatc ccttataggt taatatttga aaagttttcc 6840 ggtaaagatc ctaattctaa agacaactca gtagggattc aattgctagg catcgtgatg 6900 gccaatgacc tgcctcccta tgacccacag tgtggcatcc agagtagcga atacttccag 6960 gctttggtga ataatatgtc ctttgtaaga tataaagaag tgtatgccgc tgcagcagaa 7020 gttctaggac ttatacttcg atatgttatg gagagaaaaa acatactgga ggagtctctg 7080 tgtgaactgg ttgcgaaaca attgaagcaa catcagaata ctatggagga caagtttatt 7140 gtgtgcttga acaaagtgac caagagcttc cctcctcttg cagacaggtt catgaatgct 7200 gtgttctttc tgctgccaaa atttcatgga gtgttgaaaa cactctgtct ggaggtggta 7260 ctttgtcgtg tggagggaat gacagagctg tacttccagt taaagagcaa ggacttcgtt 7320 caagtcatga gacatagaga tgatgaaaga caaaaagtat gtttggacat aatttataag 7380 atgatgccaa agttaaaacc agtagaactc cgagaacttc tgaaccccgt tgtggaattc 7440 gtttcccatc cttctacaac atgtagggaa caaatgtata atattctcat gtggattcat 7500 gataattaca gagatccaga aagtgagaca gataatgact cccaggaaat atttaagttg 7560 gcaaaagatg tgctgattca aggattgatc gatgagaacc ctggacttca attaattatt 7620 cgaaatttct ggagccatga aactaggtta ccttcaaata ccttggaccg gttgctggca 7680 ctaaattcct tatattctcc taagatagaa gtgcactttt taagtttagc aacaaatttt 7740 ctgctcgaaa tgaccagcat gagcccagat tatccaaacc ccatgttcga gcatcctctg 7800 tcagaatgcg aatttcagga atataccatt gattctgatt ggcgtttccg aagtactgtt 7860 ctcactccga tgtttgtgga gacccaggcc tcccagggca ctctccagac ccgtacccag 7920 gaagggtccc tctcagctcg ctggccagtg gcagggcaga taagggccac ccagcagcag 7980 catgacttca cactgacaca gactgcagat ggaagaagct catttgattg gctgaccggg 8040 agcagcactg acccgctggt cgaccacacc agtccctcat ctgactcctt gctgtttgcc 8100 cacaagagga gtgaaaggtt acagagagca cccttgaagt cagtggggcc tgattttggg 8160 aaaaaaaggc tgggccttcc aggggacgag gtggataaca aagtgaaagg tgcggccggc 8220 cggacggacc tactacgact gcgcagacgg tttatgaggg accaggagaa gctcagtttg 8280 atgtatgcca gaaaaggcgt tgctgagcaa aaacgagaga aggaaatcaa gagtgagtta 8340 aaaatgaagc aggatgccca ggtcgttctg tacagaagct accggcacgg agaccttcct 8400 gacattcaga tcaagcacag cagcctcatc accccgttac aggccgtggc ccagagggac 8460 ccaataattg caaaacagct ctttagcagc ttgttttctg gaattttgaa agagatggat 8520 aaatttaaga cactgtctga aaaaaacaac atcactcaaa agttgcttca agacttcaat 8580 cgttttctta ataccacctt ctctttcttt ccaccctttg tctcttgtat tcaggacatt 8640 agctgtcagc acgcagccct gctgagcctc gacccagcgg ctgttagcgc tggttgcctg 8700 gccagcctac agcagcccgt gggcatccgc ctgctagagg aggctctgct ccgcctgctg 8760 cctgctgagc tgcctgccaa gcgagtccgt gggaaggccc gcctccctcc tgatgtcctc 8820 agatgggtgg agcttgctaa gctgtataga tcaattggag aatacgacgt cctccgtggg 8880 atttttacca gtgagatagg aacaaagcaa atcactcaga gtgcattatt agcagaagcc 8940 agaagtgatt attctgaagc tgctaagcag tatgatgagg ctctcaataa acaagactgg 9000 gtagatggtg agcccacaga agccgagaag gatttttggg aacttgcatc ccttgactgt 9060 tacaaccacc ttgctgagtg gaaatcactt gaatactgtt ctacagccag tatagacagt 9120 gagaaccccc cagacctaaa taaaatctgg agtgaaccat tttatcagga aacatatcta 9180 ccttacatga tccgcagcaa gctgaagctg ctgctccagg gagaggctga ccagtccctg 9240 ctgacattta ttgacaaagc tatgcacggg gagctccaga aggcgattct agagcttcat 9300 tacagtcaag agctgagtct gctttacctc ctgcaagatg atgttgacag agccaaatat 9360 tacattcaaa atggcattca gagttttatg cagaattatt ctagtattga tgtcctctta 9420 caccaaagta gactcaccaa attgcagtct gtacaggctt taacagaaat tcaggagttc 9480 atcagcttta taagcaaaca aggcaattta tcatctcaag ttccccttaa gagacttctg 9540 aacacctgga caaacagata tccagatgct aaaatggacc caatgaacat ctgggatgac 9600 atcatcacaa atcgatgttt ctttctcagc aaaatagagg agaagcttac ccctcttcca 9660 gaagataata gtatgaatgt ggatcaagat ggagacccca gtgacaggat ggaagtgcaa 9720 gagcaggaag aagatatcag ctccctgatc aggagttgca agttttccat gaaaatgaag 9780 atgatagaca gtgcccggaa gcagaacaat ttctcacttg ctatgaaact actgaaggag 9840 ctgcataaag agtcaaaaac cagagacgat tggctggtga gctgggtgca gagctactgc 9900 cgcctgagcc actgccggag ccggtcccag ggctgctctg agcaggtgct cactgtgctg 9960 aaaacagtct ctttgttgga tgagaacaac gtgtcaagct acttaagcaa aaatattctg 10020 gctttccgtg accagaacat tctcttgggt acaacttaca ggatcatagc gaatgctctc 10080 agcagtgagc cagcctgcct tgctgaaatc gaggaggaca aggctagaag aatcttagag 10140 ctttctggat ccagttcaga ggattcagag aaggtgatcg cgggtctgta ccagagagca 10200 ttccagcacc tctctgaggc tgtgcaggcg gctgaggagg aggcccagcc tccctcctgg 10260 agctgtgggc ctgcagctgg ggtgattgat gcttacatga cgctggcaga tttctgtgac 10320 caacagctgc gcaaggagga agagaatgca tcagttattg attctgcaga actgcaggcg 10380 tatccagcac ttgtggtgga gaaaatgttg aaagctttaa aattaaattc caatgaagcc 10440 agattgaagt ttcctagatt acttcagatt atagaacggt atccagagga gactttgagc 10500 ctcatgacaa aagagatctc ttccgttccc tgctggcagt tcatcagctg gatcagccac 10560 atggtggcct tactggacaa agaccaagcc gttgctgttc agcactctgt ggaagaaatc 10620 actgataact acccgcaggc tattgtttat cccttcatca taagcagcga aagctattcc 10680 ttcaaggata cttctactgg tcataagaat aaggagtttg tggcaaggat taaaagtaag 10740 ttggatcaag gaggagtgat tcaagatttt attaatgcct tagatcagct ctctaatcct 10800 gaactgctct ttaaggattg gagcaatgat gtaagagctg aactagcaaa aacccctgta 10860 aataaaaaaa acattgaaaa aatgtatgaa agaatgtatg cagccttggg tgacccaaag 10920 gctccaggcc tgggggcctt tagaaggaag tttattcaga cttttggaaa agaatttgat 10980 aaacattttg ggaaaggagg ttctaaacta ctgagaatga agctcagtga cttcaacgac 11040 attaccaaca tgctactttt aaaaatgaac aaagactcaa agccccctgg gaatctgaaa 11100 gaatgttcac cctggatgag cgacttcaaa gtggagttcc tgagaaatga gctggagatt 11160 cccggtcagt atgacggtag gggaaagcca ttgccagagt accacgtgcg aatcgccggg 11220 tttgatgagc gggtgacagt catggcgtct ctgcgaaggc ccaagcgcat catcatccgt 11280 ggccatgacg agagggaaca ccctttcctg gtgaagggtg gcgaggacct gcggcaggac 11340 cagcgcgtgg agcagctctt ccaggtcatg aatgggatcc tggcccaaga ctccgcctgc 11400 agccagaggg ccctgcagct gaggacctat agcgttgtgc ccatgacctc caggttagga 11460 ttaattgagt ggcttgaaaa tactgttacc ttgaaggacc ttcttttgaa caccatgtcc 11520 caagaggaga aggcggctta cctgagtgat cccagggcac cgccgtgtga atataaagat 11580 tggctgacaa aaatgtcagg aaaacatgat gttggagctt acatgctaat gtataagggc 11640 gctaatcgta ctgaaacagt cacgtctttt agaaaacgag aaagtaaagt gcctgctgat 11700 ctcttaaagc gggccttcgt gaggatgagt acaagccctg aggctttcct ggcgctccgc 11760 tcccacttcg ccagctctca cgctctgata tgcatcagcc actggatcct cgggattgga 11820 gacagacatc tgaacaactt tatggtggcc atggagactg gcggcgtgat cgggatcgac 11880 tttgggcatg cgtttggatc cgctacacag tttctgccag tccctgagtt gatgcctttt 11940 cggctaactc gccagtttat caatctgatg ttaccaatga aagaaacggg ccttatgtac 12000 agcatcatgg tacacgcact ccgggccttc cgctcagacc ctggcctgct caccaacacc 12060 atggatgtgt ttgtcaagga gccctccttt gattggaaaa attttgaaca gaaaatgctg 12120 aaaaaaggag ggtcatggat tcaagaaata aatgttgctg aaaaaaattg gtacccccga 12180 cagaaaatat gttacgctaa gagaaagtta gcaggtgcca atccagcagt cattacttgt 12240 gatgagctac tcctgggtca tgagaaggcc cctgccttca gagactatgt ggctgtggca 12300 cgaggaagca aagatcacaa cattcgtgcc caagaaccag agagtgggct ttcagaagag 12360 actcaagtga agtgcctgat ggaccaggca acagacccca acatccttgg cagaacctgg 12420 gaaggatggg agccctggat gtgaggtctg tgggagtctg cagatagaaa gcattacatt 12480 gtttaaagaa tctactatac tttggttggc agcattccat gagctgattt tcctgaaaca 12540 ctaaagagaa atgtcttttg tgctacagtt tcgtagcatg agtttaaatc aagattatga 12600 tgagtaaatg tgtatgggtt aaatcaaaga taaggttata gtaacatcaa agattaggtg 12660 aggtttatag aaagatagat atccaggctt accaaagtat taagtcaaga atataatatg 12720 tgatcagctt tcaaagcatt tacaagtgct gcaagttagt gaaacagctg tctccgtaaa 12780 tggaggaaat gtggggaagc cttggaatgc ccttctggtt ctggcacatt ggaaagcaca 12840 ctcagaaggc ttcatcacca agattttggg agagtaaagc taagtatagt tgatgtaaca 12900 ttgtagaagc agcataggaa caataagaac aataggtaaa gctataatta tggcttatat 12960 ttagaaatga ctgcatttga tattttagga tatttttcta ggttttttcc tttcatttta 13020 ttctcttcta gttttgacat tttatgatag atttgctctc tagaaggaaa cgtctttatt 13080 taggagggca aaaattttgg tcatagcatt cacttttgct attccaatct acaactggaa 13140 gatacataaa agtgctttgc attgaatttg ggataacttc aaaaatccca tggttgttgt 13200 tagggatagt actaagcatt tcagttccag gagaataaaa gaaattccta tttgaaatga 13260 attcctcatt tggaggaaaa aaagcatgca ttctagcaca acaagatgaa attatggaat 13320 acaaaagtgg ctccttccca tgtgcagtcc ctgtcccccc ccgccagtcc tccacaccca 13380 aactgtttct gattggcttt tagctttttg ttgttttttt ttttccttct aacacttgta 13440 tttggaggct cttctgtgat tttgagaagt atactcttga gtgtttaata aagttttttt 13500 ccaaaagta 13509 <210> 14 <211> 362 <212> DNA <213> Homo sapiens <400> 14 ctatctgaag cttagagatc tagagctttg gatctttcgg gtatatgtca atggaggtat 60 tattttataa tactttgcat tgacatgaag tgggttcatg ggggaaaacc atgagctgtg 120 aacattggta gcaaacaagc atatattcat ttcaaaactt tccttgcttt tagcagagag 180 aagcctgtat atgttacatg tgtgactttc agtagtttaa agagatgttt caaaaaattg 240 ttgcatgttt ttgatgcaat ttgggaaatt gtttacttca caatgtagtc attcataaaa 300 aaattcatga aaatactgaa catatgtttg aggatttttc ttttcctttt taaatttttt 360 ta 362 <210> 15 <211> 3486 <212> DNA <213> Homo sapiens <400> 15 gagccgactg cggctgcgcg gggtattcga atcggcggcg gcttctagtt tgcggttcag 60 gtttggccgc tgccggccag cgtcctctgg ccatggacac cccggaaaat gtccttcaga 120 tgcttgaagc ccacatgcag agctacaagg gcaatgaccc tcttggtgaa tgggaaagat 180 acatacagtg ggtagaagag aattttcctg agaataaaga atacttgata actttactag 240 aacatttaat gaaggaattt ttagataaga agaaatacca caatgaccca agattcatca 300 gttattgttt aaaatttgct gagtacaaca gtgacctcca tcaatttttt gagtttctgt 360 acaaccatgg gattggaacc ctgtcatccc ctctgtacat tgcctgggcg gggcatctgg 420 aagcccaagg agagctgcag catgccagtg ctgtccttca gagaggaatt caaaaccagg 480 ctgaacccag agagttcctg caacaacaat acaggttatt tcagacacgc ctcactgaaa 540 cccatttgcc agctcaagct agaacctcag aacctctgca taatgttcag gttttaaatc 600 aaatgataac atcaaaatca aatccaggaa ataacatggc ctgcatttct aagaatcagg 660 gttcagagct ttctggagtg atatcttcag cttgtgataa agagtcaaat atggaacgaa 720 gagtgatcac gatttctaaa tcagaatatt ctgtgcactc atctttggca tccaaagttg 780 atgttgagca ggttgttatg tattgcaagg agaagcttat tcgtggggaa tcagaatttt 840 cctttgaaga attgagagcc cagaaataca atcaacggag aaagcatgag caatgggtaa 900 atgaagacag acattatatg aaaaggaaag aagcaaatgc ttttgaagaa cagctattaa 960 aacagaaaat ggatgaactt cataagaagt tgcatcaggt ggtggagaca tcccatgagg 1020 atctgcccgc ttcccaggaa aggtccgagg ttaatccagc acgtatgggg ccaagtgtag 1080 gctcccagca ggaactgaga gcgccatgtc ttccagtaac ctatcagcag acaccagtga 1140 acatggaaaa gaacccaaga gaggcacctc ctgttgttcc tcctttggca aatgctattt 1200 ctgcagcttt ggtgtcccca gccaccagcc agagcattgc tcctcctgtt cctttgaaag 1260 cccagacagt aacagactcc atgtttgcag tggccagcaa agatgctgga tgtgtgaata 1320 agagtactca tgaattcaag ccacagagtg gagcagagat caaagaaggg tgtgaaacac 1380 ataaggttgc caacacaagt tcttttcaca caactccaaa cacatcactg ggaatggttc 1440 aggcaacgcc atccaaagtg cagccatcac ccaccgtgca cacaaaagaa gcattaggtt 1500 tcatcatgaa tatgtttcag gctcctacac ttcctgatat ttctgatgac aaagatgaat 1560 ggcaatctct agatcaaaat gaagatgcat ttgaagccca gtttcaaaaa aatgtaaggt 1620 catctggggc ttggggagtc aataagatca tctcttcttt gtcatctgct tttcatgtgt 1680 ttgaagatgg aaacaaagaa aattatggat taccacagcc taaaaataaa cccacaggag 1740 ccaggacctt tggagaacgc tctgtcagca gacttccttc aaaaccaaag gaggaagtgc 1800 ctcatgctga agagtttttg gatgactcaa ctgtatgggg tattcgctgc aacaaaaccc 1860 tggcacccag tcctaagagc ccaggagact tcacatctgc tgcacaactt gcgtctacac 1920 cattccacaa gcttccagtg gagtcagtgc acattttaga agataaagaa aatgtggtag 1980 caaaacagtg tacccaggcg actttggatt cttgtgagga aaacatggtg gtgccttcaa 2040 gggatggaaa attcagtcca attcaagaga aaagcccaaa acaggccttg tcgtctcaca 2100 tgtattcagc atccttactt cgtctgagcc agcctgctgc aggtggggta cttacctgtg 2160 aggcagagtt gggcgttgag gcttgcagac tcacagacac tgacgctgcc attgcagaag 2220 atccaccaga tgctattgct gggctccaag cagaatggat gcagatgagt tcacttggga 2280 ctgttgatgc tccaaacttc attgttggga acccatggga tgataagctg attttcaaac 2340 ttttatctgg gctttctaaa ccagtgagtt cctatccaaa tacttttgaa tggcaatgta 2400 aacttccagc catcaagccc aagactgaat ttcaattggg ttctaagctg gtctatgtcc 2460 atcaccttct tggagaagga gcctttgccc aggtgtacga agctacccag ggagatctga 2520 atgatgctaa aaataaacag aaatttgttt taaaggtcca aaagcctgcc aacccctggg 2580 aattctacat tgggacccag ttgatggaaa gactaaagcc atctatgcag cacatgttta 2640 tgaagttcta ttctgcccac ttattccaga atggcagtgt attagtagga gagctctaca 2700 gctatggaac attattaaat gccattaacc tctataaaaa tacccctgaa aaagtgatgc 2760 ctcaaggtct tgtcatctct tttgctatga gaatgcttta catgattgag caagtgcatg 2820 actgtgaaat cattcatgga gacattaaac cagacaattt catacttgga aacggatttt 2880 tggaacagga tgatgaagat gatttatctg ctggcttggc actgattgac ctgggtcaga 2940 gtatagatat gaaacttttt ccaaaaggaa ctatattcac agcaaagtgt gaaacatctg 3000 gttttcagtg tgttgagatg ctcagcaaca aaccatggaa ctaccagatc gattactttg 3060 gggttgctgc aacagtatat tgcatgctct ttggcactta catgaaagtg aaaaatgaag 3120 gaggagagtg taagcctgaa ggtcttttta gaaggcttcc tcatttggat atgtggaatg 3180 aattttttca tgttatgttg aatattccag attgtcatca tcttccatct ttggatttgt 3240 taaggcaaaa gctgaagaaa gtatttcaac aacactatac taacaagatt agggccctac 3300 gtaataggct aattgtactg ctcttagaat gtaagcgttc acgaaaataa aatttggata 3360 tagacagtcc ttaaaaatca cactgtaaat atgaatctgc tcactttaaa cctgtttttt 3420 tttcatttat tgtttatgta aatgtttgtt aaaaataaat cccatggaat atttccatgt 3480 aaaaaa 3486 <210> 16 <211> 2769 <212> DNA <213> Homo sapiens <400> 16 actggccgca tagagacgca gcgcacgcgc agtcgcgtat ccgtgtgatg ggcgggctgt 60 tgacggcgct gcgatggctg cctgcgaggg caggagaagc ggagctctcg gttcctctca 120 gtcggacttc ctgacgccgc cagtgggcgg ggccccttgg gccgtcgcca ccactgtagt 180 catgtaccca ccgccgccgc cgccgcctca tcgggacttc atctcggtga cgctgagctt 240 tggcgagagc tatgacaaca gcaagagttg gcggcggcgc tcgtgctgga ggaaatggaa 300 gcaactgtcg agattgcagc ggaatatgat tctcttcctc cttgcctttc tgcttttctg 360 tggactcctc ttctacatca acttggctga ccattggaaa gctctggctt tcaggctaga 420 ggaagagcag aagatgaggc cagaaattgc tgggttaaaa ccagcaaatc cacccgtctt 480 accagctcct cagaaggcgg acaccgaccc tgagaactta cctgagattt cgtcacagaa 540 gacacaaaga cacatccagc ggggaccacc tcacctgcag attagacccc caagccaaga 600 cctgaaggat gggacccagg aggaggccac aaaaaggcaa gaagcccctg tggatccccg 660 cccggaagga gatccgcaga ggacagtcat cagctggagg ggagcggtga tcgagcctga 720 gcagggcacc gagctccctt caagaagagc agaagtgccc accaagcctc ccctgccacc 780 ggccaggaca cagggcacac cagtgcatct gaactatcgc cagaagggcg tgattgacgt 840 cttcctgcat gcatggaaag gataccgcaa gtttgcatgg ggccatgacg agctgaagcc 900 tgtgtccagg tccttcagtg agtggtttgg cctcggtctc acactgatcg acgcgctgga 960 caccatgtgg atcttgggtc tgaggaaaga atttgaggaa gccaggaagt gggtgtcgaa 1020 gaagttacac tttgaaaagg acgtggacgt caacctgttt gagagcacga tccgcatcct 1080 gggggggctc ctgagtgcct accacctgtc tggggacagc ctcttcctga ggaaagctga 1140 ggattttgga aatcggctaa tgcctgcctt cagaacacca tccaagattc cttactcgga 1200 tgtgaacatc ggtactggag ttgcccaccc gccacggtgg acctccgaca gcactgtggc 1260 cgaggtgacc agcattcagc tggagttccg ggagctctcc cgtctcacag gggataagaa 1320 gtttcaggag gcagtggaga aggtgacaca gcacatccac ggcctgtctg ggaagaagga 1380 tgggctggtg cccatgttca tcaataccca cagtggcctc ttcacccacc tgggcgtatt 1440 cacgctgggc gccagggccg acagctacta tgagtacctg ctgaagcagt ggatccaggg 1500 cgggaagcag gagacacagc tgctggaaga ctacgtggaa gccatcgagg gtgtcagaac 1560 gcacctgctg cggcactccg agcccagtaa gctcaccttt gtgggggagc ttgcccacgg 1620 ccgcttcagt gccaagatgg accacctggt gtgcttcctg ccagggacgc tggctctggg 1680 cgtctaccac ggcctgcccg ccagccacat ggagctggcc caggagctca tggagacttg 1740 ttaccagatg aaccggcaga tggagacggg gctgagtccc gagatcgtgc acttcaacct 1800 ttacccccag ccgggccgtc gggacgtgga ggtcaagcca gcagacaggc acaacctgct 1860 gcggccagag accgtggaga gcctgttcta cctgtaccgc gtcacagggg accgcaaata 1920 ccaggactgg ggctgggaga ttctgcagag cttcagccga ttcacacggg tcccctcggg 1980 tggctattct tccatcaaca atgtccagga tcctcagaag cccgagccta gggacaagat 2040 ggagagcttc ttcctggggg agacgctcaa gtatctgttc ttgctcttct ccgatgaccc 2100 aaacctgctc agcctggatg cctacgtgtt caacaccgaa gcccaccctc tgcctatctg 2160 gacccctgcc tagggtggat ggctgctggt gtggggactt cgggtgggca gaggcacctt 2220 gctgggtctg tggcattttc caagggccca cgtagcaccg gcaaccgcca agtggcccag 2280 gctctgaact ggctctgggc tcctcctcgt ctctgcttta atcaggacac cgtgaggaca 2340 agtgaggccg tcagtcttgg tgtgatgcgg ggtgggctgg gccgctggag cctccgcctg 2400 cttcctccag aagacacgaa tcatgactca cgattgctga agcctgagca ggtctctgtg 2460 ggccgaccag aggggggctt cgaggtggtc cctggtactg gggtgaccga gtggacagcc 2520 cagggtgcag ctctgcccgg gctcgtgaag cctcagatgt ccccaatcca agggtctgga 2580 ggggctgccg tgactccaga ggcctgaggc tccagggctg gctctggtgt ttacaagctg 2640 gactcaggga tcctcctggc cgccccgcag ggggcttgga gggctggacg gcaagtccgt 2700 ctagctcacg ggcccctcca gtggaatggg tcttttcggt ggagataaaa gttgatttgc 2760 tctaaccgc 2769 <210> 17 <211> 566 <212> DNA <213> Homo sapiens <400> 17 gagactgact gtcggcaaaa acaaaaccaa aacaaacctt tacccacttc tcctaaacaa 60 cccctaaaaa actgctctga aaagcaggga atatcattgt gcaaagtaag ttgttttttt 120 ccacggggct gtctgcgtaa aacttgccac ttagagccct gcctgcaccg tcgtcacggc 180 ccagcctgca ggtgagcttc ctcgcgcccc cgcctgacct gagtgcccct ccctgagtca 240 gacacagtgt cgtcgccctg caggaagcca cgggggcccg tctgctgctc gtggccaggc 300 tgggcctttg gggtgcccga ccccctccaa gagcaagccc cttagatgcc cggcaagtcn 360 ctctctaccc tcccatcccc ttgggaggtt tccccacact gtgtccagtg tgaggctnaa 420 gttgagatca tagcacagga ggctctgggg tccttgaaga atgaggcgct tgatgatgag 480 caggatctga agttgctgcc tggaggaagg ttttaagtca tcaatggaca ggcagcttgt 540 tccagtaatt tggaaatttg gggaag 566 <210> 18 <211> 931 <212> DNA <213> Homo sapiens <400> 18 tttcgtcggc ccgccccttg gcttctgcac tgatggtggg tggatgagta atgcatccag 60 gaagcctgga ggcctgtggt ttccgcaccc gctgccaccc ccgcccctag cgtggacatt 120 tatcctctag cgctcaggcc ctgccgccat cgccgcagat ccagcgccca gagagacacc 180 agagaaccca ccatggcccc ctttgagccc ctggcttctg gcatcctgtt gttgctgtgg 240 ctgatagccc ccagcagggc ctgcacctgt gtcccacccc acccacagac ggccttctgc 300 aattccgacc tcgtcatcag ggccaagttc gtggggacac cagaagtcaa ccagaccacc 360 ttataccagc gttatgagat caagatgacc aagatgtata aagggttcca agccttaggg 420 gatgccgctg acatccggtt cgtctacacc cccgccatgg agagtgtctg cggatacttc 480 cacaggtccc acaaccgcag cgaggagttt ctcattgctg gaaaactgca ggatggactc 540 ttgcacatca ctacctgcag ttttgtggct ccctggaaca gcctgagctt agctcagcgc 600 cggggcttca ccaagaccta cactgttggc tgtgaggaat gcacagtgtt tccctgttta 660 tccatcccct gcaaactgca gagtggcact cattgcttgt ggacggacca gctcctccaa 720 ggctctgaaa agggcttcca gtcccgtcac cttgcctgcc tgcctcggga gccagggctg 780 tgcacctggc agtccctgcg gtcccagata gcctgaatcc tgcccggagt ggaagctgaa 840 gcctgcacag tgtccaccct gttcccactc ccatctttct tccggacaat gaaataaaga 900 gttaccaccc agcagaaaaa aaaaaaaaaa a 931 <210> 19 <211> 2215 <212> DNA <213> Homo sapiens <400> 19 agcttttctc ttctgtcaac cccacacgcc tttggcacaa tgaagtgggt aacctttatt 60 tcccttcttt ttctctttag ctcggcttat tccaggggtg tgtttcgtcg agatgcacac 120 aagagtgagg ttgctcatcg gtttaaagat ttgggagaag aaaatttcaa agccttggtg 180 ttgattgcct ttgctcagta tcttcagcag tgtccatttg aagatcatgt aaaattagtg 240 aatgaagtaa ctgaatttgc aaaaacatgt gttgctgatg agtcagctga aaattgtgac 300 aaatcacttc ataccctttt tggagacaaa ttatgcacag ttgcaactct tcgtgaaacc 360 tatggtgaaa tggctgactg ctgtgcaaaa caagaacctg agagaaatga atgcttcttg 420 caacacaaag atgacaaccc aaacctcccc cgattggtga gaccagaggt tgatgtgatg 480 tgcactgctt ttcatgacaa tgaagagaca tttttgaaaa aatacttata tgaaattgcc 540 agaagacatc cttactttta tgccccggaa ctccttttct ttgctaaaag gtataaagct 600 gcttttacag aatgttgcca agctgctgat aaagctgcct gcctgttgcc aaagctcgat 660 gaacttcggg atgaagggaa ggcttcgtct gccaaacaga gactcaagtg tgccagtctc 720 caaaaatttg gagaaagagc tttcaaagca tgggcagtag ctcgcctgag ccagagattt 780 cccaaagctg agtttgcaga agtttccaag ttagtgacag atcttaccaa agtccacacg 840 gaatgctgcc atggagatct gcttgaatgt gctgatgaca gggcggacct tgccaagtat 900 atctgtgaaa atcaagattc gatctccagt aaactgaagg aatgctgtga aaaacctctg 960 ttggaaaaat cccactgcat tgccgaagtg gaaaatgatg agatgcctgc tgacttgcct 1020 tcattagctg ctgattttgt tgaaagtaag gatgtttgca aaaactatgc tgaggcaaag 1080 gatgtcttcc tgggcatgtt tttgtatgaa tatgcaagaa ggcatcctga ttactctgtc 1140 gtgctgctgc tgagacttgc caagacatat gaaaccactc tagagaagtg ctgtgccgct 1200 gcagatcctc atgaatgcta tgccaaagtg ttcgatgaat ttaaacctct tgtggaagag 1260 cctcagaatt taatcaaaca aaattgtgag ctttttgagc agcttggaga gtacaaattc 1320 cagaatgcgc tattagttcg ttacaccaag aaagtacccc aagtgtcaac tccaactctt 1380 gtagaggtct caagaaacct aggaaaagtg ggcagcaaat gttgtaaaca tcctgaagca 1440 aaaagaatgc cctgtgcaga agactatcta tccgtggtcc tgaaccagtt atgtgtgttg 1500 catgagaaaa cgccagtaag tgacagagtc accaaatgct gcacagaatc cttggtgaac 1560 aggcgaccat gcttttcagc tctggaagtc gatgaaacat acgttcccaa agagtttaat 1620 gctgaaacat tcaccttcca tgcagatata tgcacacttt ctgagaagga gagacaaatc 1680 aagaaacaaa ctgcacttgt tgagctcgtg aaacacaagc ccaaggcaac aaaagagcaa 1740 ctgaaagctg ttatggatga tttcgcagct tttgtagaga agtgctgcaa ggctgacgat 1800 aaggagacct gctttgccga ggagggtaaa aaacttgttg ctgcaagtca agctgcctta 1860 ggcttataac atctacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa 1920 tgaagatcaa aagcttattc atctgttttc tttttcgttg gtgtaaagcc aacaccctgt 1980 ctaaaaaaca taaatttctt taatcatttt gcctcttttc tctgtgcttc aattaataaa 2040 aaatggaaag aatctaatag agtggtacag cactgttatt tttcaaagat gtgttgctat 2100 cctgaaaatt ctgtaggttc tgtggaagtt ccagtgttct ctcttattcc acttcggtag 2160 aggatttcta gtttctgtgg gctaattaaa taaatcacta atactcttct aagtt 2215 <210> 20 <211> 5189 <212> DNA <213> Homo sapiens <400> 20 atggccaagt cgggtggctg cggcgcggga gccggcgtgg gcggcggcaa cggggcactg 60 acctgggtga acaatgctgc aaaaaaagaa gagtcagaaa ctgccaacaa aaatgattct 120 tcaaagaagt tgtctgttga gagagtgtat cagaagaaga cacaacttga acacattctt 180 cttcgtcctg atacatatat tgggtcagtg gagccattga cgcagttcat gtgggtgtat 240 gatgaagatg taggaatgaa ttgcagggag gttacctttg tgccaggttt atacaagatc 300 tttgatgaaa ttttggttaa tgctgctgac aataaacaga gggataagaa catgacttgt 360 attaaagttt ctattgatcc tgaatctaac attataagca tttggaataa tgggaaaggc 420 attccagtag tagaacacaa ggtagagaaa gtttatgttc ctgctttaat ttttggacag 480 cttttaacat ccagtaacta tgatgatgat gagaaaaaag ttacaggtgg tcgtaatggt 540 tatggtgcaa aactttgtaa tattttcagt acaaagttta cagtagaaac agcttgcaaa 600 gaatacaaac acagttttaa gcagacatgg atgaataata tgatgaagac ttctgaagcc 660 aaaattaaac attttgatgg tgaagattac acatgcataa cattccaacc agatctgtcc 720 aaatttaaga tggaaaaact tgacaaggat attgtggccc tcatgactag aagggcatat 780 gatttggctg gttcgtgtag aggggtcaag gtcatgttta atggaaagaa attgcctgta 840 aatggatttc gcagttatgt agatctttat gtgaaagaca aattggatga aactggggtg 900 gccctgaaag ttattcatga gcttgcaaat gaaagatggg atgtttgtct cacattgagt 960 gaaaaaggat tccagcaaat cagctttgta aatagtattg caactacaaa aggtggacgg 1020 cacgtggatt atgtggtaga tcaagttgtt ggtaaactga ttgaagtagt taagaaaaag 1080 aacaaagctg gtgtatcagt gaaaccattt caagtaaaaa accatatatg ggtttttatt 1140 aattgcctta ttgaaaatcc aacttttgat tctcagacta aggaaaacat gactctgcag 1200 cccaaaagtt ttgggtctaa atgccagctg tcagaaaaat tttttaaagc agcctctaat 1260 tgtggcattg tagaaagtat cctgaactgg gtgaaattta aggctcagac tcagctgaat 1320 aagaagtgtt catcagtaaa atacagtaaa atcaaaggta ttcccaaact ggatgatgct 1380 aatgatgctg gtggtaaaca ttccctggag tgtacactga tattaacaga gggagactct 1440 gccaaatcac tggctgtgtc tggattaggt gtgattggac gagacagata cggagttttt 1500 ccactcaggg gcaaaattct taatgtacgg gaagcttctc ataaacagat catggaaaat 1560 gctgaaataa ataatattat taaaatagtt ggtctacaat ataagaaaag ttacgatgat 1620 gcagaatctc tgaaaacctt acgctatgga aagattatga ttatgaccga tcaggatcaa 1680 gatggttctc acataaaagg cctgcttatt aatttcatcc atcacaattg gccatcactt 1740 ttgaagcatg gttttcttga agagttcatt actcctattg taaaggcaag caaaaataag 1800 caggaacttt ccttctacag tattcctgaa tttgacgaat ggaaaaaaca tatagaaaac 1860 cagaaagcct ggaaaataaa gtactataaa ggattgggta ctagtacagc taaagaagca 1920 aaggaatatt ttgctgatat ggaaaggcat cgcatcttgt ttagatatgc tggtcctgaa 1980 gatgatgctg ccattacctt ggcatttagt aagaagaaga ttgatgacag aaaagaatgg 2040 ttaacaaatt ttatggaaga ccggagacag cgtaggctac atggcttacc agagcaattt 2100 ttatatggta ctgcaacaaa gcatttgact tataatgatt tcatcaacaa ggaattgatt 2160 ctcttctcaa actcagacaa tgaaagatct ataccatctc ttgttgatgg ctttaaacct 2220 ggccagcgga aagttttatt tacctgtttc aagaggaatg ataaacgtga agtaaaagtt 2280 gcccagttgg ctggctctgt tgctgagatg tcggcttatc atcatggaga acaagcattg 2340 atgatgacta ttgtgaattt ggctcagaac tttgtgggaa gtaacaacat taacttgctt 2400 cagcctattg gtcagtttgg aactcggctt catggtggca aagatgctgc aagccctcgt 2460 tatattttca caatgttaag cactttagca aggctacttt ttcctgctgt ggatgacaac 2520 ctccttaagt tcctttatga tgataatcaa cgtgtagagc ctgagtggta tattcctata 2580 attcccatgg ttttaataaa tggtgctgag ggcattggta ctggatgggc ttgtaaacta 2640 cccaactatg atgctaggga aattgtgaac aatgtcagac gaatgctaga tggcctggat 2700 cctcatccca tgcttccaaa ctacaaaaac tttaaaggca cgattcaaga acttggtcaa 2760 aaccagtatg cagtcagtgg tgaaatattt gtagtggaca gaaacacagt agaaattaca 2820 gagcttccag ttagaacttg gacacaggta tataaagaac aggttttaga acctatgcta 2880 aatggaacag ataaaacacc agcattaatt tctgattata aagaatatca tactgacaca 2940 actgtgaaat ttgtggtgaa aatgactgaa gagaaactag cacaagcaga agctgctgga 3000 ctgcataaag tttttaaact tcaaactact cttacttgta attccatggt actttttgat 3060 catatgggat gtctgaagaa atatgaaact gtgcaagaca ttctgaaaga attctttgat 3120 ttacgattaa gttattacgg tttacgtaag gagtggcttg tgggaatgtt gggagcagaa 3180 tctacaaagc ttaacaatca agcccgtttc attttagaga agatacaagg gaaaattact 3240 atagagaata ggtcaaagaa agatttgatt caaatgttag tccagagagg ttatgaatct 3300 gacccagtga aagcctggaa agaagcacaa gaaaaggcag cagaagagga tgaaacacaa 3360 aaccagcatg atgatagttc ctccgattca ggaactcctt caggcccaga ttttaattat 3420 attttaaata tgtctctgtg gtctcttact aaagaaaaag ttgaagaact gattaaacag 3480 agagatgcaa aagggcgaga ggtcaatgat cttaaaagaa aatctccttc agatctttgg 3540 aaagaggatt tagcggcatt tgttgaagaa ctggataaag tggaatctca agaacgagaa 3600 gatgttctgg ctggaatgtc tggaaaagca attaaaggta aagttggcaa acctaaggtg 3660 aagaaactcc agttggaaga gacaatgccc tcaccttatg gcagaagaat aattcctgaa 3720 attacagcta tgaaggcaga tgccagcaaa aagttgctga agaagaagaa gggtgatctt 3780 gatactgcag cagtaaaagt ggaatttgat gaagaattca gtggagcacc agtagaaggt 3840 gcaggagaag aggcattgac tccatcagtt cctataaata aaggtcccaa acctaagagg 3900 gagaagaagg agcctggtac cagagtgaga aaaacaccta catcatctgg taaacctagt 3960 gcaaagaaag tgaagaaacg gaatccttgg tcagatgatg aatccaagtc agaaagtgat 4020 ttggaagaaa cagaacctgt ggttattcca agagattctt tgcttaggag agcagcagcc 4080 gaaagaccta aatacacatt tgatttctca gaagaagagg atgatgatgc tgatgatgat 4140 gatgatgaca ataatgattt agaggaattg aaagttaaag catctcccat aacaaatgat 4200 ggggaagatg aatttgttcc ttcagatggg ttagataaag atgaatatac attttcacca 4260 ggcaaatcaa aagccactcc agaaaaatct ttgcatgaca aaaaaagtca ggattttgga 4320 aatctcttct catttccttc atattctcag aagtcagaag atgattcagc taaatttgac 4380 agtaatgaag aagattctgc ttctgttttt tcaccatcat ttggtctgaa acagacagat 4440 aaagttccaa gtaaaacggt agctgctaaa aagggaaaac cgtcttcaga tacagtccct 4500 aagcccaaga gagccccaaa acagaagaaa gtagtagagg ctgtaaactc tgactcggat 4560 tcagaatttg gcattccaaa gaagactaca acaccaaaag gtaaaggccg aggggcaaag 4620 aaaaggaaag catctggctc tgaaaatgaa ggcgattata accctggcag gaaaacatcc 4680 aaaacaacaa gcaagaaacc gaagaagaca tcttttgatc aggattcaga tgtggacatc 4740 ttcccctcag acttccctac tgagccacct tctctgccac gaaccggtcg ggctaggaaa 4800 gaagtaaaat attttgcaga gtctgatgaa gaagaagatg atgttgattt tgcaatgttt 4860 aattaagtgc ccaaagagca caaacatttt tcaacaaata tcttgtgttg tccttttgtc 4920 ttctctgtct cagacttttg tacatctggc ttattttaat gtgatgatgt aattgacggt 4980 tttttattat tgtggtaggc cttttaacat tttgttctta cacatacagt tttatgctct 5040 tttttactca ttgaaatgtc acgtactgtc tgattggctt gtagaattgt tatagactgc 5100 cgtgcattag cacagatttt aattgtcatg gttacaaact acagacctgc tttttgaaat 5160 gaaatttaaa cattaaaaat ggaactgtg 5189 <210> 21 <211> 1143 <212> DNA <213> Homo sapiens <400> 21 tgcaacgccg gggccagagt cttaaaaccg agggcccgca ggggtccccg cggccgccgc 60 gatgcagaaa tacgagaaac tggaaaagat tggggaaggc acctacggaa ctgtgttcaa 120 ggccaaaaac cgggagactc atgagatcgt ggctctgaaa cgggtgaggc tggatgacga 180 tgatgagggt gtgccgagtt ccgccctccg ggagatctgc ctactcaagg agctgaagca 240 caagaacatc gtcaggcttc atgacgtcct gcacagcgac aagaagctga ctttggtttt 300 tgaattctgt gaccaggacc tgaagaagta ttttgacagt tgcaatggtg acctcgatcc 360 tgagattgta aagtcattcc tcttccagct actaaaaggg ctgggattct gtcatagccg 420 caatgtgcta cacagggacc tgaagcccca gaacctgcta ataaacagga atggggagct 480 gaaattggct gattttggcc tggctcgagc ctttgggatt cccgtccgct gttactcagc 540 tgaggtggtc acactgtggt accgcccacc ggatgtcctc tttggggcca agctgtactc 600 cacgtccatc gacatgtggt cagccggctg catctttgca gagctggcca atgctgggcg 660 gcctcttttt cccggcaatg atgtcgatga ccagttgaag aggatcttcc gactgctggg 720 gacgcccacc gaggagcagt ggccctctat gaccaagctg ccagactata agccctatcc 780 gatgtacccg gccacaacat ccctggtgaa cgtcgtgccc aaactcaatg ccacagggag 840 ggatctgctg cagaaccttc tgaagtgtaa ccctgtccag cgtatctcag cagaagaggc 900 cctgcagcac ccctacttct ccgacttctg tccgccctag gccccgggac ccccggcctc 960 caggctgggg cctggcctat ttaagccccc tcttgagagg ggtgagacag tgggggtgcc 1020 tggtgcgctg tgctccagca gtgctgggcc cagccggggt ggggtgcctg agcccgaatt 1080 tctcactccc tttgtggact ttatttaatt tcataaattg gctcctttcc cacagtcaaa 1140 aaa 1143 <210> 22 <211> 6972 <212> DNA <213> Homo sapiens <400> 22 ggcatggaac ctaaagacta gaggcggttg tgtgagtcag gaagaggggc cagatatctg 60 agtgttcctc tttagtttct tcaattgcag ataatatggt gtctaatttt atgttgttca 120 ggaaagacag tggttcctga ctcaggaaga cagtctcaga aacatgtgga atgatattga 180 gctgctaaca aatgatgata ccggaagtgg gtacctgagt gtcggttcaa gaaaagaaca 240 tggaactgct ttatatcaag tagatttgct agtgaagatc tcttctgaaa aggcctcatt 300 aaatccaaag atacaggcat gcagcttaag tgatgggttt attattgtag ccgaccaatc 360 agtgatattg cttgacagta tttgtagatc acttcaattg catcttgtct ttgatactga 420 agtggatgta gttggccttt gtcaagaagg aaagtttctt ttggttggcg agagaagtgg 480 caacctacat cttattcatg taacatcaaa acaaacacta ctcactaatg catttgttca 540 gaaagctaac gatgaaaatc ggcggactta ccagaatctt gtcattgaga aggatggttc 600 aaatgaaggt acctattata tgctacttct tacatacagt ggattttttt gtattacaaa 660 ccttcagctt ttaaaaattc aacaagcaat tgagaatgta gacttcagta cagcaaaaaa 720 gttacaagga caaatcaagt ccagttttat ttctactgaa aattatcata ctcttggttg 780 tctcagtctt gtggctggag atttagcaag tgaagttcct gtgataattg ggggaaccgg 840 taattgtgca ttctcaaaat gggaaccaga ttcttccaag aaaggaatga cagttaagaa 900 ccttattgat gcagagatta ttaaaggtgc aaagaagttc cagctgatag acaatctact 960 ttttgttctt gatactgata acgtgctgag tttatgggat atttacactc taactcctgt 1020 atggaactgg ccctctcttc acgtagaaga gtttcttctt actacagaag cagactctcc 1080 ttcatcagtc acgtggcaag gaattacaaa tctcaaatta atagctctga cagcttcagc 1140 taataagaag atgaaaaacc tcatggttta ttcattacct acaatggaaa tactatattc 1200 tttggaagta tctagtgttt cttctctggt ccaaacagga attagcacag ataccatata 1260 ccttttagaa ggagtttgca aaaatgatcc aaaattgtct gaagactcag tctctgtgtt 1320 agtactcaga tgtcttacgg aagctttacc agaaaacaga ttgagtcggt tacttcacaa 1380 acacagattt gctgaagctg agagttttgc cattcagttt ggactagatg ttgagcttgt 1440 ttacaaggtc aagtcaaatc atatattgga gaaactggca ttgagttctg tggatgccag 1500 tgaacagacc gaatggcaac aacttgtaga cgacgctaag gaaaatctac ataagatcca 1560 ggatgatgaa tttgtggtga attactgcct gaaagctcag tggataacct atgaaaccac 1620 tcaagagatg ctgaattatg ccaaaaccag gcttttgaag aaagaagata aaactgctct 1680 catttattct gatggcttga aagaggtgct aagagctcat gcaaaattga ctacttttta 1740 tggagcattt ggaccagaaa aattcagtgg cagttcttgg attgaatttc taaataatga 1800 agatgatctt aaagatattt ttttacagct aaaagaagga aaccttgttt gtgcacagta 1860 tctttggctt cgacatcggg caaactttga aagcagattt gatgtgaaaa tgctggagag 1920 cttgctcaac tcaatgtctg catcagtctc tttgcaaaag ctgtgtccat ggtttaaaaa 1980 tgatgtgatt ccatttgtaa gaaggactgt gcctgaagga cagataattc ttgcaaaatg 2040 gttggaacaa gcagccagga accttgaatt aactgataag gcaaattggc cagaaaatgg 2100 acttcaattg gcagagatat tttttacagc agaaaaaaca gacgagttgg gattggcatc 2160 ttcctggcat tggatttcct tgaaagatta tcagaacaca gaggaagtat gtcagctaag 2220 gactttggta aataacttgc gagagttgat cacgttgcat aggaagtaca actgcaaatt 2280 agccctctct gattttgaga aggaaaatac aaccaccata gtgttccgaa tgtttgataa 2340 agtgctggcc ccagagctta ttccctccat cttagagaag tttataagag tttacatgag 2400 agaacatgac ttgcaagagg aggaacttct cttgctgtac atagaggatt tactgaatag 2460 atgcagctca aagtccacat cactctttga aacagcatgg gaagcaaagg ccatggcagt 2520 aatagcgtgt ttatctgaca cggacctcat atttgatgcc gtgctcaaga tcatgtatgc 2580 ggcagtggtt ccttggagtg cagctgtgga gcaactggtg aaacagcacc tggaaatgga 2640 ccatcccaaa gtcaagttat tacaggaaag ttacaaacta atggagatga aaaaactttt 2700 acgaggctat ggaataagag aggtaaatct cttaaacaag gaaataatga gagtggttag 2760 atacattctc aaacaagatg tcccatcttc tttagaagat gctttaaagg tagcccaagc 2820 gtttatgtta tctgatgatg agatctacag tctaagaatt attgacctga ttgatagaga 2880 acagggtgaa gactgtctcc ttctgttgaa gtctttgcct cctgctgaag ctgagaaaac 2940 tgcagaaaga gtcatcatat gggcacgact ggcattacaa gaagagccag atcattctaa 3000 agagggcaag gcctggagaa tgtctgtagc gaagacatcc gtggacattc ttaagatact 3060 atgtgacatt cagaaagaca atctgcagaa gaaggacgaa tgtgaagaaa tgttgaaact 3120 atttaaagag gttgctagct tacaggagaa ctttgaggtc tttctttcat ttgaagatta 3180 tagcaatagt tccctggtag cagatctccg tgagcagcac attaaagctc acgaagttgc 3240 acaggcgaaa cacaaacctg ggagcacccc agagcccata gctgctgagg tgaggagccc 3300 aagcatggaa tcaaagctgc acagacaggc actggccctg cagatgtcca aacaagagct 3360 ggaggcagag ctgaccttga gagccttaaa agatgggaac atcaaaacag cactgaaaaa 3420 atgcagcgac ttgtttaagt atcactgcaa tgctgacact gggaaattgc tatttctgac 3480 atgtcagaag ctttgtcaga tgttggctga taatgtccca gtgacagtgc ctgtgggact 3540 gaatcttcct tccatgatac atgatctagc aagccaagct gccaccattt gcagtccaga 3600 ttttttacta gatgctttag aactatgtaa acatacttta atggctgtag agctttccag 3660 acaatgccaa atggatgact gtggaatcct catgaaagct tcttttggga cacataaaga 3720 tccatatgaa gagtggtctt acagtgactt cttcagtgaa gatggaattg ttcttgagtc 3780 acagatggtg cttccagtga tttatgaact gatttcatct cttgtgcctc tagctgaaag 3840 caagagatat cccttggagt ctaccagttt gccatactgc tcccttaatg aaggagatgg 3900 ccttgtttta cctgttataa attccatctc tgccctgctt cagaatcttc aggaatctag 3960 ccagtgggag ctagccctaa gatttgtggt tggttcattt ggtacctgtc ttcagcactc 4020 tgtgtcaaac ttcatgaatg ccactttgag tgaaaagtta tttggagaga ctacattagt 4080 taaatcaagg catgttgtta tggaattgaa agaaaaagct gttatattta tcagggaaaa 4140 tgctacaaca ctactgcaca aagtatttaa ttgtcgcttg gtagatcttg acctggcgtt 4200 gggttactgc actctcttac ctcaaaaaga tgtgtttgaa aatctctgga agctcataga 4260 taaagcatgg cagaattacg acaaaatctt ggcaatatct ctggtgggct ctgagctggc 4320 aagtctctat caggaaatag aaatggggct taagttccgt gaactcagta ctgatgccca 4380 gtggggcatt cgtcttggta aacttggtat ttcttttcaa ccagttttca ggcaacattt 4440 tctcaccaag aaagacctca ttaaagctct tgtggagaat atagatatgg acacaagcct 4500 cattttggaa tattgcagca catttcagtt ggactgcgat gcagttcttc agctcttcat 4560 tgaaacgctg ctccacaaca caaatgccgg ccaaggccag ggagatgcaa gcatggactc 4620 tgcaaagcgg cggcatccca aactcctggc caaagccctt gagatggttc ctttactgac 4680 gagcacaaaa gatttggtca tcagtcttag tggaatacta cataagttgg atccttatga 4740 ctatgaaatg attgaagttg tcttgaaagt tatagaacga gctgatgaaa agataaccaa 4800 tattaatatt aatcaggcat tgagtattct gaaacatttg aagtcataca gaagaatttc 4860 tcctcccgtg gatctagaat atcagtatat gttggaacat gtcataactt tgccatcagc 4920 tgcccaaact agactgcctt ttcacctgat attctttggc acagcacaga acttctggaa 4980 aattctctct acagaactca gtgaagaatc tttcccaaca ttgctcttaa tttcgaaatt 5040 aatgaagttc tctctggaca ctctgtacgt gtctacagca aaacacgttt tcgaaaaaaa 5100 actgaagcca aagctcctga agttaacaca agctaaatcc tcaacactga ttaacaagga 5160 aataactaag atcacgcaga ccatcgaatc ctgcttactc tctatagtca acccagagtg 5220 ggctgtagct attgccatca gccttgccca ggatatccct gaaggttcct tcaagatatc 5280 tgctttgaaa ttctgccttt atttagctga gagatggcta cagaatatcc catcgcagga 5340 cgaaaaacgt gaaaaagccg aggctttgtt gaagaagctt catatccagt accggcgatc 5400 gggcacagaa gctgtgctca tagcccacaa gctgaacact gaggaatatt taagagtgat 5460 cggaaagcca gcacatctta ttgtcagtct ctacgaacat cctagcatca atcaaagaat 5520 tcagaattca tctggcacag attatcctga tattcatgca gcagctaaag aaatagccga 5580 agtcaatgaa attaatttgg aaaaagtctg ggacatgttg ttggaaaaat ggctatgccc 5640 ttcaacaaaa cctggtgaaa aaccatcaga attatttgaa cttcaagaag atgaagccct 5700 acgaagagtg cagtatctcc tcctgtctcg tccaattgat tatagttcaa gaatgctgtt 5760 tgtatttgca acatcaacta caaccacatt aggtatgcat cagttaactt ttgcccatag 5820 aactcgagct cttcagtgtc tcttctattt ggctgacaag gaaactatag aatctctctt 5880 taaaaaaccc attgaagaag tgaaatctta tttgagatgt ataacttttc tggcatcatt 5940 tgagactttg aatatcccca tcacatatga attattttgc agcagtccta aagaaggaat 6000 gattaagggt ctgtggaaaa accacagcca cgagtccatg gcagtaagat tggtgactga 6060 gctgtgttta gaatacaaaa tctatgacct gcagctttgg aatggactct tgcaaaagct 6120 tctgggcttc aatatgattc cttatctaag gaaagtttta aaagccatct ccagtatcca 6180 ttctttatgg caggttccct acttcagcaa agcgtggcag cgtgtgatac agataccact 6240 gctttcagcc tcttgtcctt taagtcctga tcagctgtca gattgttctg agagtctcat 6300 cgctgtcctc gaatgtccag tctcaggtga tcttgacctg atcggagtcg ccaggcagta 6360 tatccagtta gaacttccgg cttttgcatt agcttgtctg atgctcatgc cccactcaga 6420 gaaaagacac cagcaaatta agaattttct gggttcctgt gaccctcagg ttattttaaa 6480 gcaattggaa gagcatatga acacgggcca gctagcagga ttttcacatc aaattagaag 6540 tctgattttg aataatatca tcaataagaa ggagtttggg attttggcaa agaccaaata 6600 ctttcaaatg ttgaagatgc atgcgatgaa taccaacaat atcactgagc tagtgaacta 6660 tttggcaaat gacttaagtt tagatgaagc ttcagtcttg ataactgaat attcaaagca 6720 ctgcgggaaa cctgtgcctc cagacactgc tccctgtgaa attctgaaga tgtttcttag 6780 tggattatcg taaatcactg aacctttttt tcaagaagga caagaatttt ggagtctgct 6840 attaatggac catatttatt acagttttta aattgtacaa tctctgtatt atagctattt 6900 gtctaacatt accccacatg taataaataa aacaatatga gcataattgc cccataaaga 6960 actcaaaaaa aa 6972 <210> 23 <211> 595 <212> DNA <213> Homo sapiens <400> 23 gggcaaggct gggccgggaa gggcgtgggt tgaggagagg ctccagaccc gcacgccgcg 60 cgcacagagc tctcagcgcc gctcccagcc acagcctccc gcgcctcgct cagctccaac 120 atggcaaaaa tctccagccc tacagagact gagcggtgca tcgagtccct gattgctgtc 180 ttccagaagt atgctggaaa ggatggttat aactacactc tctccaagac agagttccta 240 agcttcatga atacagaact agctgccttc acaaagaacc agaaggaccc tggtgtcctt 300 gaccgcatga tgaagaaact ggacaccaac agtgatggtc agctagattt ctcagaattt 360 cttaatctga ttggtggcct agctatggct tgccatgact ccttcctcaa ggctgtccct 420 tcccagaagc ggacctgagg accccttggc cctggccttc aaacccaccc cctttccttc 480 cagcctttct gtcatcatct ccacagccca cccatcccct gagcacacta accacctcat 540 gcaggcccca cctgccaata gtaataaagc aatgtcactt ttttaaaaca tgaaa 595 <210> 24 <211> 951 <212> DNA <213> Homo sapiens <400> 24 attggtggga tgagcaatcc gagttcccgg atgagggaac attctgcagt ataaagggag 60 cagggaaggc gggagacagc gcagtttgaa tcgcggtgcg acgaaggagt aggtggtggg 120 atctcaccgt gggtccgatt agccttttct ctgccttgct tgcttgagct tcagcggaat 180 tcgaaatggc tggcggtaag gctggaaagg actccggaaa ggccaagaca aaggcggttt 240 cccgctcgca gagagccggc ttgcagttcc cagtgggccg tattcatcga cacctaaaat 300 ctaggacgac cagtcatgga cgtgtgggcg cgactgccgc tgtgtacagc gcagccatcc 360 tggagtacct caccgcagag gtacttgaac tggcaggaaa tgcatcaaaa gacttaaagg 420 taaagcgtat tacccctcgt cacttgcaac ttgctattcg tggagatgaa gaattggatt 480 ctctcatcaa ggctacaatt gctggtggtg gtgtcattcc acacatccac aaatctctga 540 ttgggaagaa aggacaacag aagactgtct aaaggatgcc tggattcctt gttatctcag 600 gactctaaat actctaacag ctgtccagtg ttggtgattc cagtggactg tatctctgtg 660 aaaaacacaa ttttgccttt ttgtaattct atttgagcaa gttggaagtt taattagctt 720 tccaaccaac caaatttctg cattcgagtc ttaaccatat ttaagtgtta ctgtggcttc 780 aaagaagcta ttgattctga agtagtgggt tttgattgag ttgactgttt ttaaaaaact 840 gtttggattt taattgtgat gcagaagtta tagtaacaaa catttggttt tgtacagaca 900 ttatttccac tctggtggat aagttcaata aaggtcatat cccaaacaaa a 951 <210> 25 <211> 2254 <212> DNA <213> Homo sapiens <400> 25 gggaattctg aaagccgctg gcggaccgcg cgcagcggcc agagaccgag ccctaaggag 60 agtgcggcgc ttcccgaggc gtgcagctgg gaactgcaac tcatctgggt tgtgcgcaga 120 aggctggggc aagcgagtag agaagtggag cgtaagccag gggcgttggg ggccgtgcgg 180 gtcgggcgcg tgccacgccc gcggggtgaa gtcggagcgc ggggcctgct ggagagagga 240 gcgctgcgga ccgagtaatg gcaatgcaga tgcagcttga agcaaatgca gatacttcag 300 tggaagaaga aagctttggc ccacaaccca tttcacggtt agagcagtgt ggcataaatg 360 ccaacgatgt gaagaaattg gaagaagctg gattccatac tgtggaggct gttgcctatg 420 cgccaaagaa ggagctaata aatattaagg gaattagtga agccaaagct gataaaattc 480 tggctgaggc agctaaatta gttccaatgg gtttcaccac tgcaactgaa ttccaccaaa 540 ggcggtcaga gatcatacag attactactg gctccaaaga gcttgacaaa ctacttcaag 600 gtggaattga gactggatct atcacagaaa tgtttggaga attccgaact gggaagaccc 660 agatctgtca tacgctagct gtcacctgcc agcttcccat tgaccggggt ggaggtgaag 720 gaaaggccat gtacattgac actgagggta cctttaggcc agaacggctg ctggcagtgg 780 ctgagaggta tggtctctct ggcagtgatg tcctggataa tgtagcatat gctcgagcgt 840 tcaacacaga ccaccagacc cagctccttt atcaagcatc agccatgatg gtagaatcta 900 ggtatgcact gcttattgta gacagtgcca ccgcccttta cagaacagac tactcgggtc 960 gaggtgagct ttcagccagg cagatgcact tggccaggtt tctgcggatg cttctgcgac 1020 tcgctgatga gtttggtgta gcagtggtaa tcactaatca ggtggtagct caagtggatg 1080 gagcagcgat gtttgctgct gatcccaaaa aacctattgg aggaaatatc atcgcccatg 1140 catcaacaac cagattgtat ctgaggaaag gaagagggga aaccagaatc tgcaaaatct 1200 acgactctcc ctgtcttcct gaagctgaag ctatgttcgc cattaatgca gatggagtgg 1260 gagatgccaa agactgaatc attgggtttt tcctctgtta aaaaccttaa gtgctgcagc 1320 ctaatgagag tgcactgctc cctggggttc tctacaggcc tcttcctgtt gtgactgcca 1380 ggataaagct tccgggaaaa cagctattat atcagctttt ctgatggtat aaacaggaga 1440 caggtcagta gtcacaaact gatctaaaat gtttattcct tctgtagtgt attaatctct 1500 gtgtgttttc tttggttttg gaggaggggt atgaagtatc tttgacatgg tgccttagga 1560 atgacttggg tttaacaagc tgtctactgg acaatcttat gtttccaaga gaactaaagc 1620 tggagagacc tgacccttct ctcacttcta aattaatggt aaaataaaat gcctcagcta 1680 tgtagcaaag ggaatgggtc tgcacagatt ctttttttct gtcagtaaaa ctctcaagca 1740 ggtttttaag ttgtctgtct gaatgatctt gtgtaagggt ttggttatgg agtcttgtgc 1800 caaacctact aggccattag cccttcacca tctacctgct tggtctttca ttgctaagac 1860 taactcaaga taatcctaga gtcttaaagc atttcaggcc agtgtggtgt cttgcgcctg 1920 tactcccagc actttgggag gccgaggcag gtggatcgct tgagccagga gttttaagtc 1980 cagcttggcc aagatggtga aatcccatct ctacaaaaaa tgcagaactt aatctggaca 2040 cactgttaca cgtgcctgta gtcccagcta ctctatagcc tgaggtggga gaatcactta 2100 agcctggaag gtggaagttg cagtgagtcg agattgcact gctgcattcc agccagggtg 2160 acagagtgag accatgtttc aaacaagaaa catttcagag ggcaagtaaa cagatttgat 2220 tgtgaggctt ctaataaagt agttattagt agtg 2254 <210> 26 <211> 2684 <212> DNA <213> Homo sapiens <400> 26 cccgagagga gtcggtggca gcggcggcgg cgggaccggc agcagcagca gcagcagcag 60 cagcaaccac tagcctcctg ccccgcggcg ctgccgcacg agccccacga gccgctcacc 120 ccgccgttct cagcgctgcc cgaccccgct ggcgcgccct cccgccgcca gtcccggcag 180 cgccctcagt tgtcctccga ctcgccctcg gccttccgcg ccagccgcag ccacagccgc 240 aacgccaccc gcagccacag ccacagccac agccccaggc atagccttcg gcacagcccc 300 ggctccggct cctgcggcag ctcctctggg caccgtccct gcgccgacat cctggaggtt 360 gggatgctct tgtccaaaat caactcgctt gcccacctgc gcgccgcgcc ctgcaacgac 420 ctgcacgcca ccaagctggc gcccggcaag gagaaggagc ccctggagtc gcagtaccag 480 gtgggcccgc tactgggcag cggcggcttc ggctcggtct actcaggcat ccgcgtctcc 540 gacaacttgc cggtggccat caaacacgtg gagaaggacc ggatttccga ctggggagag 600 ctgcctaatg gcactcgagt gcccatggaa gtggtcctgc tgaagaaggt gagctcgggt 660 ttctccggcg tcattaggct cctggactgg ttcgagaggc ccgacagttt cgtcctgatc 720 ctggagaggc ccgagccggt gcaagatctc ttcgacttca tcacggaaag gggagccctg 780 caagaggagc tggcccgcag cttcttctgg caggtgctgg aggccgtgcg gcactgccac 840 aactgcgggg tgctccaccg cgacatcaag gacgaaaaca tccttatcga cctcaatcgc 900 ggcgagctca agctcatcga cttcgggtcg ggggcgctgc tcaaggacac cgtctacacg 960 gacttcgatg ggacccgagt gtatagccct ccagagtgga tccgctacca tcgctaccat 1020 ggcaggtcgg cggcagtctg gtccctgggg atcctgctgt atgatatggt gtgtggagat 1080 attcctttcg agcatgacga agagatcatc aggggccagg ttttcttcag gcagagggtc 1140 tcttcagaat gtcagcatct cattagatgg tgcttggccc tgagaccatc agataggcca 1200 accttcgaag aaatccagaa ccatccatgg atgcaagatg ttctcctgcc ccaggaaact 1260 gctgagatcc acctccacag cctgtcgccg gggcccagca aatagcagcc tttctggcag 1320 gtcctcccct ctcttgtcag atgcccgagg gaggggaagc ttctgtctcc agcttcccga 1380 gtaccagtga cacgtctcgc caagcaggac agtgcttgat acaggaacaa catttacaac 1440 tcattccaga tcccaggccc ctggaggctg cctcccaaca gtggggaaga gtgactctcc 1500 aggggtccta ggcctcaact cctcccatag atactctctt cttctcatag gtgtccagca 1560 ttgctggact ctgaaatatc ccgggggtgg ggggtggggg tgggtcagaa ccctgccatg 1620 gaactgtttt cttcatcatg agttctgctg aatgccgcga tgggtcaggt aggggggaaa 1680 caggttggga tgggatagga ctagcaccat tttaagtccc tgtcacctct tccgactctt 1740 tctgagtgcc ttctgtgggg actccggctg tgctgggaga aatacttgaa cttgcctctt 1800 ttacctgctg cttctccaaa aatctgcctg ggttttgttc cctatttttc tctcctgtcc 1860 tccctcaccc cctccttcat atgaaaggtg ccatggaaga ggctacaggg ccaaacgctg 1920 agccacctgc ccttttttct gcctccttta gtaaaactcc gagtgaactg gtcttccttt 1980 ttggttttta cttaactgtt tcaaagccaa gacctcacac acacaaaaaa tgcacaaaca 2040 atgcaatcaa cagaaaagct gtaaatgtgt gtacagttgg catggtagta tacaaaaaga 2100 ttgtagtgga tctaattttt aagaaatttt gcctttaagt tattttacct gtttttgttt 2160 cttgttttga aagatgcgca ttctaacctg gaggtcaatg ttatgtattt atttatttat 2220 ttatttggtt cccttcctat tccaagcttc catagctgct gccctagttt tctttcctcc 2280 tttcctcctc tgacttgggg accttttggg ggagggctgc gacgcttgct ctgtttgtgg 2340 ggtgacggga ctcaggcggg acagtgctgc agctccctgg cttctgtggg gcccctcacc 2400 tacttaccca ggtgggtccc ggctctgtgg gtgatgggga ggggcattgc tgactgtgta 2460 tataggataa ttatgaaaag cagttctgga tggtgtgcct tccagatcct ctctggggct 2520 gtgttttgag cagcaggtag cctgctggtt ttatctgagt gaaatactgt acaggggaat 2580 aaaagagatc ttattttttt ttttatactt ggcgtttttt gaataaaaac cttttgtctt 2640 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2684 <210> 27 <211> 1066 <212> DNA <213> Homo sapiens <400> 27 ggctgcagag gggaaggcgg ctaccagtgt aaagccagag ctgaggttct tgatagtcca 60 caatgggtga accacagcaa gtgagtgcac ttccaccacc tccaatgcaa tatatcaagg 120 aatatacgga tgaaaatatt caagaaggct tagctcccaa gcctccccct ccaataaaag 180 acagttacat gatgtttggc aatcagttcc aatgtgatga tcttatcatc cgccctttgg 240 aaagtcaggg catcgaacgg cttcatccta tgcagtttga tcacaagaaa gaactgagaa 300 aacttaatat gtctatcctt attaatttct tggacctttt agatatttta ataaggagcc 360 ctgggagtat aaaacgagaa gagaaactag aagatcttaa gctgcttttt gtacacgtgc 420 atcatcttat aaatgaatac cgaccccacc aagcaagaga gaccttgaga gtcatgatgg 480 aggtccagaa acgtcaacgg cttgaaacag ctgagagatt tcaaaagcac ctggaacgag 540 taattgaaat gattcagaat tgcttggctt ctttgcctga tgatttgcct cattcagaag 600 caggaatgag agtaaaaact gaaccaatgg atgctgatga tagcaacaat tgtactggac 660 agaatgaaca tcaaagagaa aattcaggtc ataggagaga tcagattata gagaaagatg 720 ctgccttgtg tgtcctaatt gatgagatga atgaaagacc atgaaagatg tttctttttc 780 tttttttcct tttgataata gcatcatata ttagttcatt ttcttttgga cagtcttaag 840 agaagtttca ctaaaaatgt aaacagcttt aatcttgact ccaaattttt caattatgag 900 atgtcatagg cagtaatttc gctgtataac aagcatagac aaatgagtgt ccctgcacta 960 agaagaatca ctttaaaaag caaagtgtta gctgctgttg tatgggacat tcctatgttt 1020 tagagttgca gtaaaacttt gatgataacc tcaataatag caaagt 1066 <210> 28 <211> 40403 <212> DNA <213> Homo sapiens <400> 28 gatccaaaac gcccactaac cttggcgcgt cccagtctcc accccaaacc taactcaggt 60 gaaaatggcg ccacgcgcgg gggcggggct agaggtacaa agagagtgtc tattggttgg 120 gagcggcacg ggccgccttc ttcgcttcac cattggctcg ctccgtaagg caagagaacc 180 cactagggga tgagcccgaa ctagggatgt gacagagcgc gagacccagc ctaaagagag 240 cccggagcca gcgtgggagg ccgctgccgt cgcgcgcctt ggtgagtgcc ctccacccgg 300 cccctgctcc ctcccccagc tctccccggc tacgcggcca gccctcggcg tgccagcgcg 360 agaccctttg ccacccgccc cccccaccgc ccttttgcgc ctgcgcgaga cccccagcta 420 ccgcacggtt gtccagagga cagaagatcc gtcttctcat tgggcagcgg gactggaggg 480 ttctggttcg gattgaccgg ctttgtgttc cgttctagcg ctgcacgcca gacaccggcc 540 tttcaatatc cgtctcttcc ctgcaggttg acggcgttgc acgctctcgc ggggaggctc 600 tggctttcca aacgctggca ccgagggttg tagttctgat tcgttttctt tcctctgtcc 660 cccagttgca gttttcagga ctacgtgggg gagggaatag ctttttgttg aacggtttaa 720 gacgctgacc tgtgcaactg gaccacgcct ggttcctgtg tctcttacca aaccgtgacc 780 ccggagcaca ggactgggtt tggtggtcgt gagcagtttg tgacccttga aggaagacac 840 caggcctggt cctgtatctc cctcgccaga ctgtgaccag ggagggctgg gatcaggtgt 900 tgttcccatg tgcctcccac cagactttga cccccgaggg ctgagaccgg gactgtttct 960 accacatcat aatatggctt ctaaagggct ggaacaagct ttcagccttt ctgtggcctt 1020 gtgtttcagt catgttcttt ttcttttctt ttttatttta ttttgagaca gagtctcgct 1080 ctgttgccca ggctggagtg cagtggcatg accccggctc actgcagcct ctgcctccca 1140 ggttcaagcg attctcctgc ctcagcctcc tgagtagctg taactacagg cgcacgccac 1200 cacacctggc taatttttgt atttttagta gagacggggt tttgccatgt tggccgggct 1260 ggtcttgaac tcctgagctc aagtggtcca ctcgtcttgg cctcccaaag tgctgggatt 1320 acaggcgtga gccaccgcgc ccggccttct tttttagagg cagagtctca gactggaggg 1380 cagtgatgtg gtcactgctc acttcagcct tgaagtcctg ggctcaaagc gatcctcctg 1440 cctcagccta cctactagct gggactacag gcctttgtca ccacacctga ctgattttct 1500 tattttttta gagacagttt cgctgtgttg cccaggccgg acttgaattc ctggcctcag 1560 gtgctgctcc tgcatcagcc tcccaaagca ctggaattac ctgccacggt gcctggcctt 1620 tagtcatggt cttaaaacag aatgtaggcc gggcgcagtg gctcacgcct gtaatcccag 1680 cactttggga ggctgaggcg ggcggatcgt gaggtcagga gatcaagacc atcctggcta 1740 acacggtgaa accccgtctc tactaaaaat acaaaaaatt agctgggcgt ggtggcaggc 1800 acctgtagtc ccagctactc gggaggctga ggcaggagaa tcgtttgaac ccggaaggca 1860 gaggttgcag tgagccgagg tcgcaccact ccactccagc ctgggtgaca gagcaagact 1920 ccgtctgaaa aaaaaaaaaa aaaacggaat gtaattagaa gtgttacaat cctgtctgtt 1980 aactggtaaa ttcggtccat ttacatttct catgataata aactatttga atttgatttt 2040 attatctcat tctgtacttt ctatttgtcc aggtttttct gttccttttt tttttttttt 2100 tttaacttcc tgcctataca cacgcagcca tcagcccaca aagacatgac taccaacgcg 2160 ggccccttgc acccatactg gcctcagcac ctaagactgg acaactttgt acctaatgac 2220 cgccccacct ggcatatact ggctggcctc ttctctgtca caggggtctt agtcgtgacc 2280 acatggctgt tgtcaggtcg tgctgcggtt gtcccattgg ggacttggcg gcgactgtcc 2340 ctgtgctggt ttgcagtgtg tgggttcatt cacctggtga tcgagggctg gttcgttctc 2400 tactacgaag acctgcttgg agaccaagcc ttcttatctc aactctgtga gtcctgattt 2460 ctttcatatg ctgtgggatg ggatttgctg ggcagggatc ggcttgcatg tttacctatc 2520 cacctattct tcttccattg atttatttta aatttttatt taatctttta aaaaatttat 2580 tataggccgg gcacagtggc tcacgcttgt aatcccagca ctttgggagg ccgaggcagg 2640 tggatcactt gaggtcagga atttgagacc agcctggtca acatggcaaa accccatctc 2700 tactaaaaat acaaaaatta gccaggcgcg gtggctcaag cctgtaatcc cagcactttg 2760 ggaggccgag gcaggcagat cacgaggtcg ggagttgaag accagccagg ccaagatgat 2820 gaaaccccat ctctactaaa aatacaaaaa ttagccgggt gtggtggcac acgcctgtaa 2880 tcccagctac tagggaggct gaggcaggag aattgcttga acctgggagg cggaggttgc 2940 agtgagccaa gaccatgcca ttgcactcca gcctgggcaa cagagtgaga ctttgtctca 3000 aaaaaaaaat tattatgtat tgttattatt attctttttg ttttttgccc ttctctaaaa 3060 ctggtagata acttattttt gagacaaggt cttgctctgt tgcccaggct ggagtgcagt 3120 ggtatgatga ttgctcactg caacctccaa ctcctgggtt caagcgatcg tcttgcctca 3180 gcctccccag tagctgggac tatactatag gtgcacacct ttatgcctgg ctaatatttt 3240 cacttttttg tagagacaag gtcttgctat gttgctcagg ctgttcttta actcctgggc 3300 tcaagcaatc cttccacctc agcctcccaa aattctggga tgacaggtgc gcaccaccgt 3360 gcccagcctt atttaacttt tttgttgcat gtatattcac gtgggtcaaa aaaccattta 3420 aagagatttg cagtgaaaat ctgctttcta tccactaagt ttccccaaac gctgttaggc 3480 actgttgata gttgtttatg tttcttttca gtttatttac acacgtaagt ctcaatttgc 3540 tcaattgtaa aaggaggata atagtaataa ccaactatat gtaagatact tagaacagtg 3600 tttggcaaac agtggttgcc atgtaactgt tcactattat tatcattatt tgcacttttc 3660 cctttttaca caaatggtaa tatgctatat atacttctaa tcttttctct ttttctttct 3720 ttccttacaa gaaaaccaaa gaagccattt tcttttttga gacggggtct cgctctgtca 3780 cccaggctag agtgcagtgg catgattata gctcactgca accttgaact cctgggcaat 3840 caagcaatcc tcctgcctca gcctccctag tagctgggat tataggcatg tgccacccca 3900 ccaagttatt ttttttttaa caactttttt ttttaagaga tggcgtcttg ctttgttgcc 3960 caggctgttc tccaactcct ggcttcaagt gatctgccca cctcagcctc ccaaagtgct 4020 aggattacaa gcatgagcca ccgcacccag ctgctttttt taatgaggtc actcctcatg 4080 atttcataaa gagctttcaa agcatggaca ttgtacagtt gcttgacttg tgtagtattg 4140 atgggcattt tccctcaatc ttctgccatt ataaacaagg ccgggcagag tggctcatgc 4200 ctgtaatccc agcactttgt gaggcgaagg cgggcagatc acctgaggtc aggagtttga 4260 gaccagtctg gccaacatag tgaaaccccg tctctactaa aagtctaaaa attagctggg 4320 cgtggtggca ggtgcctgta atcccagcta ctcaggaggc tgaggcagga gaatctctgg 4380 gacctgggag gcggaggttg tggtgagctg agattgcgcc actgcacact ccagcctgag 4440 cgataagagc aaggctccgt ctcaaaaaaa aaaaaaaaaa aaaaaaacat tacaggcatg 4500 agccattgtg cccggctggt cagatgtttc ttaaatttta gtcattccag tagatgtgag 4560 tgatatctca ttatggtttt aatttgcttt tccttagtga ctaatggaag tttgaacatc 4620 tttcatatac ttattggcca tttagaaatc ctctttgtga agaacctatt caagtcttct 4680 gcctatttta tattggatga tctttttctt tctttctttt tttttttttt ttttgagaca 4740 gggtcttacc ctgttgtcca ggctgagcac tgtggtgcta tcatagctca ctgcagcctc 4800 aacctcctgg gctcaagaca tcctcccact gcagcctggg actgtaggca cgtgccacca 4860 cgtccagcta atttttgtat gttttataga gttgggggtc tcactatatt gttcagactg 4920 gtcttgaact cctttatgca agccatcatc ccacctcagc ctcccaaagt gttgggatta 4980 caggcatgag ccatcgtgcc cggcggtctt tttctttctg attctctgct cactcttgta 5040 ttcactcatc tgttcaccta cattctctct ctctcattgg ctacttcact cactccatca 5100 tctacacctg cttcctttta taccacacac acttcttgag taccaatcac agccacactg 5160 ttttgtgtca ggctttacac atattacctt gttttagaga aataaaccac tagaatccaa 5220 acagttaccc catttcacgg atgaggaagc agacgcatgg gaaggttatg aagtctgtct 5280 tcttgcaggg acccccagct ctcacaagtg tgtgttcctt tcactgcctt tattcttcat 5340 atctctctct tcttttcttc agggaaagag tatgccaagg gagacagccg atacatcctg 5400 taagtgtttg cctctgtcaa tggagactgg cattggtttt cggggggtgg tgagttgggg 5460 agcactaatg ggctaacctg taggaagagc acaccgatac cagtgtcccc tcatgctttc 5520 tcctgcaggg gtgacaactt cacagtgtgc atggaaacca tcacagcttg cctgtgggga 5580 ccactcagcc tgtgggtggt gatcgccttt ctccgccagc atcccctccg cttcattcta 5640 cagcttgtgg tctctgtggg taaggaaagg gcactagagg ggcactgggc actagagggg 5700 ttgatggggg atccacagac acagatgtat ccctgtgggt gggatctctc aacggtgccc 5760 ttccaggggt aagtcagact gaatgacaaa ccccctgagg ctctggaaag gtcatgccct 5820 tctctgagcc tgcactctca ggtggggagg gttcattttt cttcctcctc ctccttctcc 5880 atcacaaagt ctcctgtgaa ggttacatga ggtggcccag ggtggcaaga agcccctgga 5940 acctccagga tcagggctct gagatccctt catgtaagat tctgtcatat tttttttaaa 6000 acagggtctg gctctgtcac ccaggccaga gtgctatggt gtgatctcgg ctcactgcaa 6060 cctccacctc ccagactcaa gcgatcttcc tgcctcagtc tcctgagtag ctgggactac 6120 aggcatgtgc caccgtgcct ggctaacttt tgtattttta gtagagatgg ggtttcgcca 6180 tgttgcccag gctggtctca agctcctgag ctcaaacagt cctcctggct tggcctcccg 6240 aagtactggg attacaggtg tgagccactg tgcccggcct cagtcatctt gtgttattaa 6300 attgttagct ttctttagtt ctagcgatat gagttatctt tagtcccaga atcctaagct 6360 gtcttggatt tgaggatttt gaacttcctt aaatctgaag gtgtgagctc tcctgagttc 6420 tgaaattctc agctctctgg tgtctggaat ctcacttttc tgatttctca gattttcagc 6480 tctgtgattt cagaatactt agctctgaga ccttgaatga tgacttggaa agtgctttgg 6540 aatagagaat tggcgaaagt gtccccttcc tcactggggc ttctccttcc cctcctgcca 6600 cccacaggcc agatctatgg ggatgtgctc tacttcctga cagagcaccg cgacggattc 6660 cagcacggag agctgggcca ccctctctac ttctggtttt actttgtctt catgaatgcc 6720 ctgtggctgg tgctgcctgg agtccttgtg cttgatgctg tgaagcacct cactcatgcc 6780 cagagcacgc tggatgccaa ggccacaaaa gccaagagca agaagaactg aggagtggtg 6840 gaccaggctc gaacactggc cgaggaggag ctctctgcct gccagaagag tctagtcctg 6900 ctcccacagt ttggagggac aaagctaatt gatctgtcac actcaggctc atgggcaggc 6960 acaagaaggg gaataaaggg gctgtgtgaa ggcactgctg ggagccatta gaacacagat 7020 acaagagaag ccaggaggtc tatgatggtg acgattttta aaatcaggaa ataaaagatc 7080 ttgactctaa cactgagaga tccttaatta ctaaccccag agatgcgcta tgactgaccc 7140 cacagatccc accatcattc acttattcca gacccccatc agcatctaaa gacctcccac 7200 ctctgacctc acaaacccct atcactgacc ccccgccaga ccccataact cactacacag 7260 accctatcac tggccccaca gtcccctggt cttaactcga gctgccataa cagaatgcca 7320 cagactaggc ttaaaccacc gaagttcatt ttctcacagt tctggagtcc aagatcaagg 7380 tgtcagcagg tttgacttct cctgaggccc ctgtccgtag cttgcaggtg gccaccttct 7440 cagtgtcctc acatggtctc tatgaactag cgtccctgtc cctggtgtct ctctgtgtgt 7500 ccaaatttcc tttttttttt tttttttttg agacagggcc tcgctctgtg tcaggctgga 7560 gtgcagtggt atgatcatgg ttcactgcag cctctacctc cctggctcca gcgatcctcc 7620 tgcctcagcc tcctaagtag ctgggactac aggtgtgcac taccacacat ggctatattt 7680 attttttttt atagcaatgg actctcacta tgttgcccag gctggtctca aacacctggg 7740 ctcaagtgat cctcccacct caaccttcca agtaactggg acaacaggca catgccatta 7800 tacctaattt ttgttttgtt tttttttttt gagacggagt ttcactcttg ttgcccaggc 7860 tggagtgcaa tggcacgatc ttggctcacc acaacctctg cctcctgggt taaagcaatt 7920 ctcctgcctc agcctcccgg gtaggtggga tcacaggcat gtgccaccat gctcagctaa 7980 ttttgtattt ttagtagaga cggggtttct ccatgttggt caagctggtc gcgaactccc 8040 gacctcaggt gatctacccg cctctgcctc ccaaagtgcc aggattacag gtgtgaacca 8100 ccatgtccgg caatattttt tcaatttttt gtagagatgg ggtctcacta tgttgcccaa 8160 gctgatctca aactcctagg ctcaagtggt cctcccacct cagcctccca agtagctgag 8220 actacaggtg tgaactacca tgcctagccc aaatttcctt ttatgaggac accatttgac 8280 cagcctgggc aacatggtga aaccccatct ctacaaaaaa aattttgaaa attagctggg 8340 catcatgagg ccacggtggg aggatcatct gagctaggga ggtgtaggct gcagtgagcc 8400 atgatcacgg tgagagcctg tcttaaaaaa aaaaaggagg tggggggtgg gcaccagtca 8460 ggcacagtgg ctcatgccta taatcccagg ctgacacaag tggatcacct gaggtcagga 8520 gtttgagacc agcctggcca acatggtaaa actccatctc tactaaaaat acaaaaatta 8580 gccatgcatg gtggcacatg cctgtaatcc cagctacttg ggaggctgag gcaggagaat 8640 cacttgaacc tgggaagttg aggtggcagt gagccaacat catggcacta ctgcactcca 8700 gtctgggcaa cagagtgaga ctctgtccca aaaaaaaaag tggggggcac catttgtatt 8760 ggattaggcc cactctatga gtcccatttt aacttaacca cccttttaaa gtccctatct 8820 ccaaatatag tcacattctg tggtattggg ggttagggct ttaacatatg aatttgggga 8880 ggacacagtt cagtctataa cattctgctc tctctggcct cccagaattc atgtccttgc 8940 atgcaaaata ccttcacccc catcccagca gcccaaaact ctcttttgtt tttttggaga 9000 cagggtcttg ctctgtggcc caggctggag tgcaacggca cgatctcagg tcactgcaac 9060 cacagggttt cactatgttg gcctggctgg tcttgaactc ctggcctcag atgatccacc 9120 cacctcagcc tcccaaagtg ttgggattat aggcataatt cactgtgcca taagccactc 9180 tgaaagctct taatcaagtc tagcattaac tttcagtccc aagtcttacc taaatatcat 9240 ccaaatcaag tgtaaatgag actggaggta tgattcatcc tgatgcaaaa attcttctct 9300 agctgtgaac ccgtgaaacc agataaatca tctgcttcca aaattcagtg gtaggacaag 9360 cataagctag atagatattt ccattccaaa aaggagaaat cacaaagaag aaagggatca 9420 cagtccaggc gtggtgactc acgcatgtaa tcccagcatt ttgggaggct gagatgggag 9480 ggtcacttga gcccaggtat ttgagaccac cctgggctac atggtgaaac cccgcctcta 9540 caaaaaacta aaaaattagc caggtatggt ggtacatgcc tatagtccca gctcctcagg 9600 aggctgaggt gggaggattg attaagccca ggaggtcgag gctgcagtga gccctcttct 9660 caccagtgca ccccagactg ggcgacagag caagaccctg tctcaggaga aaaaacaggg 9720 atcacaggtt ccgaataagt ttgaaaccaa atagggcaaa ttctattaga tttttaaggc 9780 ttgagaataa tcctgtttgg ctctatgttc tgtcctctgg gcccaccaga ttgggggccc 9840 cactttcctg gttcactgga gaggcggtgt ctctccctga gccctgggtg gcagcctggc 9900 ccactgaaac agaggaggcc tctttgccct ctggaactga ggaggagaca gccccacctt 9960 tgggatcatt ctcccttttt cttgaagtat aatgcatgtt cacagccaga aagctctgtt 10020 gtcgtgtcct gttgaatccc agaagtccta cagtcttctt tcattttgtc ccatctctgt 10080 cctctttagt cccagctggc cgtgtttctg ctggtattac ccatctgtat tcctggcttc 10140 tgccaagatg gctgattagg tcagtgagtc acacccatga tctctttgtg gcatgattgt 10200 ttagccacac cctttgtctt ctcaccagaa cacattctca gcttttgcag tgttggatag 10260 gctgagaact tttttatctt cacattcgag ttcccttctg cctgacaatt tcttttgcaa 10320 tttctctctt tcctcttgca ttctactaga agcagcaagg agaaaaaggc cacataatat 10380 gctgcttaga aatctcctta gctaaatctc ccaagttcgc ctctcacaag ttctaccttc 10440 cacaaaacac tagaatacaa ttaaccaagt tctttgcctt ccctccattt tccaataaca 10500 tattcctcat ttccttctga ggcctcacca gaagcacttt caacatccat atttctacca 10560 gtagccttca agataattgt cttagtcatt tggactgctc tgacaaaata ctataaactg 10620 ggtagcttat aggcaactga aatttatttc tcacagttct ggggtctggg aagtccaaaa 10680 tcaaggtgtt ggcaaattca gtgtctagtg agggcctgct tcctcacaga tggctccttc 10740 cctctgtacc cttatatggt gggagggtag aactccggtc ccttcatccc ttataaggga 10800 atgacctaat cacctcccaa aggccccacc tcctaatatc attacactgg ggattaggtt 10860 tcaacatagg aattggaggt tggggggaca caaatattaa gatcatagca gcaacatagg 10920 ctttttctaa catgcacctc aaaactcttt cagcctctac ccattaccca gttccaaagc 10980 tacttccatg ttttaggtat ttattatggc agcaccccac ttcccaggac caaaatctgt 11040 gtcagttttc taaaactgcc ataacaaaat gccacatacc tggtggctta aacaacagaa 11100 atttatttcc tcagagttct ggaggcggaa aatccaagtt caaggtgtca accagtttag 11160 tgtcccctga ggcttgtaga tggtcacctt ctcgccatgt cctcacacag tcttccctct 11220 gcctgcgcat gtcggtgtcc taatctcttc ttatagggac accagccaga gtggattggg 11280 acccgccttc accaacttca ttttaactta atcacctctt gaaaggccct attttcaaat 11340 acagtcacat tctgaagtat tgggggttag ggcttcagca tgaattttgg ggagatacca 11400 ttcagtcagt aataccgctc tgtgctcacc ccactcactc cctaatactt agcctcacag 11460 atcttccatc attcacccca caaaccccca tcacatgccc tgattactca gcccacagat 11520 tcccctgcat tgctgccaca tggacccccc caacacccac cctatagact tcccatcaca 11580 aaccctaaag atcccccatc actcacccca caggccctat cgtgaaccct acatattcac 11640 gtcattcacc tcacagagcc acattactca tccaacagac tccacccctg gatcattcag 11700 cttattggcc cctaatcact tcactcactc tacagactca ctcatcactg actctacaga 11760 gctctaatca ctcatcccat tgacacccca ttactaaccc cacaggtgcc tcccactcat 11820 ctcacaggcc ctccatctct cacaccacaa agccctctca ccttatgagc tagcacatca 11880 gcacccctac agacccccag tcattccccc accccacaga tgcccccgtc accccataga 11940 tcctcatcag ccatctacag atcccccatt cctcaaagtc ctccttcact ccccctacag 12000 acttgcccca cagcccccat cattaatccc acagaatcct gccactcgcc actcaatacc 12060 ccattcactc cacaggctcc tcatgaccct acagaccccg tcactacccc acagatccct 12120 attactcagt ttattatccc ctgatcatac cttccagaga ggccccatcg ctaaccccac 12180 agaccctaat cctcccctgt gttagtcggc tctggcttcc gtaacaaaat gccacagacc 12240 aggtggctta aacaacaaac agtttctcac acttcgggag gttggacagt ccaagtgcaa 12300 ggtgccatca gggttggtgt ctggtggggt ttctctcctt ggcttgcaga tggctacctt 12360 cttgctgtgt cctcacgtgg ccctttctct gtgcactcat gcccagtgtc cctcttctta 12420 taaggatacc agttctactg aattagggcc ccacccttat aatctcattt aaccttaatt 12480 acctccttaa aggctctatt tcagatatag tgacattatg ttgaaatatt gggggctggt 12540 tcccctgata ttagggcttc aacatatgaa tttggggagg aggacatcat tcagttcatg 12600 acactcccca tcactcaccc cacagatgcc acagctctca cctcacagag cccccaacac 12660 tcctaccaca tatattccat cactcagcct cttggcttct gataagccac cccacagatc 12720 ccccatcact cttcccacat accccatcaa ctcctaagat acccatcact ctccctacca 12780 acacacattc attcgtttca cagattgccc attattgacc ccacagaaac cccgtaactc 12840 accacacaga cctcaacccc atcactcacc cccacaggcc cctatcaccc ccaaaatctt 12900 cactctgaag atcccataac tcaccccaga agcccctcat cagtcaccct aacaacccct 12960 atcactgaca ccacagaccc accactcatc ctacagatgc ccctttacta accctataag 13020 catcccataa ctcaccttgc agaagccatc actcaaccca cagagtccat ctctcatccc 13080 acagacccct tatcactcac accaccatcc catctctcaa ctcacggtcc tccacaatcc 13140 accatataca ccccatcact cacccacaga tgccatcatt cacccctcag acccccatga 13200 cttacctcat agtgcaccta tcatgtaccc acagactccc atccacccca gggatcctcc 13260 gtcactctcc acagacctgc tattattcac ccaacagaca cccctcactt actctacaga 13320 cccccatcac tcatcctgcc gtctatcatt accttataga ccctccatca taaaacaact 13380 gggtacttga gaagttttga agagatggaa aagaataaat aataaaacca cagatacctg 13440 tagactggct tcaagtgacc tctgtaaggc cgggcacagt ggctcactcc tgtaatccca 13500 acactttggg aggctgaggc gggcagatca cctgagggtt gggagttcaa gaccagcctg 13560 gccaacatgg tgaaacccct tctgcactaa aaatacaaaa aaattagcca ggtgtggtgc 13620 caggcacctg taatcccagc tacttgggag gctggggcag gagaatcact tgaacccggg 13680 aggcagaggt tgcagtgagc tgagactgca ccattgcact caagcctggg caacaagaac 13740 aaaactccgt ctcaaaaaaa gaaatatcaa gtgacctgtg gacttcagtt caaatcctgg 13800 ctctgcttag gcctacagta tatagctttg gagaaatgcc tcactgttaa ggtcaaagcc 13860 ctgcatgatc tcactctatt ctcacctcgt ctgctgtcac tcacctatca ttcactctac 13920 ttaaaggcat gctgacttcc ttgcttttcc tcaaacacaa caggcatagc cccaagttcc 13980 atccattgca ctgcctactc tctgtgacac tacccccttt gaccttgagc ttgtttctcc 14040 ctggctttca gtactctaat ctgtagaatg cttagagtaa taacacctac ctgctatggt 14100 tcgaatgttt ctcccctcca aaactcatgt tgaaactaaa tctctttttt aacagaatta 14160 aggaggtggg aaatctgact acggtatttg agagatggga ccttgagcgg taattaggat 14220 tagattagat gaggtcataa gggtggggca ttagtggttt tctaagagga gaaacagatc 14280 tgagctagca aggtcagcac ccttaccatg tgatgccctg ctctgcctcg ccactccaca 14340 gagaggcccc accagcagaa ggccctcacc agatgtgact ccttgaccat ggacttccca 14400 gcctccagaa ctgtaagaaa taaatttctt ttctttcttt tttttttttg gtgggggggg 14460 ggtgttgttg ttgttgttgt ttttagagac agggtctcac tctgtcaccc agactagagt 14520 gtagtggcat gatcacagct cactgcagcc tcaaacttct gagcataagc aatcctcctg 14580 cctcagcctc ctaagtagct agtactacag gcatactgcc atgctcagct aatttttaaa 14640 tttttttgta gagacagggt cttgctatgt tgctgaggct gttttgaact ggcctcaaag 14700 caatcctccc acctcagcct ctcaaatttc tttataaatt acccagtctt gggtatttga 14760 ttatagcaac agaaaaatgg actaagatac tacctcatag ggtttttatg cagattataa 14820 gaattaattt atgtagactg cctagcatat actttatatt tgttgaatgg aagaatgaat 14880 aaacaaaaaa gaaagttctc cccaggacta tggcaaggac ctcctttttg atctccttgc 14940 ttccagtatc tttccatcca aagctctccc caggaccaag acagaggcat ctgaccacat 15000 catacccctg tctaaacctt tgccccagtg tccttaggat cgattccaaa ctccaggcta 15060 atggtttgca catcccaccc tatgataaat gaaaagcagg ctcttactcc ttgtttccat 15120 cagaaaatcc agcagtgcta taagtgattt tgactctaaa cacatggggc aagagagaca 15180 tgccaataat ccttttctgg ctttcagaga aaatccccat tatttatacc ttctaaaaat 15240 agagatatct atttaatgtt aataccaagg caacatgttg tcttaaaaga caccaaaata 15300 gaattgcaga cttacctaaa aagttaacct tgagggttgc gtccatatga cacggacaca 15360 atagttggag tgctagtatc ttacaagact cctttgttgg aaataacatt tgtttttgtt 15420 ttttgtttac tttttttttt tgagacggag tctcgctctg ttgcccaggt tggagtgcag 15480 gctggagtgc agtggcggct cactgcaagc tccgcctccc aggttcacac cattctcctg 15540 cctcagcctc ccgagtagct gggactacag gcgcccgcca ccacgcctgg ctaattattt 15600 tgtatttttg gtagagacgg ggtttcaccg tgttagccag gatggtctcc atctcctgac 15660 ctcgtaatcc gcccgcctcg gcctcctaaa gtgctgggat tacaggcgtg agccactgtg 15720 cccggccaga aataacattt gtaagtgcag cctgtatttt gtccaaaccg cacggatgtt 15780 gtgcaattaa gtgggaagac tgcctttttg cattttgcca catataaagt ttctcagaag 15840 agtctaagat atattcaata attcagccaa tatctagtag acatacacca tttaagaaca 15900 ggaccaacct taacatgtta tgaagattag gtaagacaaa agcaaagttt tgtgggcttt 15960 tttttttttt taatcaggtt ctcactctgt cacccaggct ggagtgtagt ggcgtgatca 16020 caactccatt gcagcctgga cctcccaggc tcaagtaatc ctcccacctc agcctcccga 16080 atagctagga gcacaggtgc gcaccatcag acccagctaa tttttttttt ttaattttgt 16140 agggacaggg tcttcctatg ttgcccaggc tggtctcaaa ctccccggct caagcgatct 16200 tcccacttcg gcctcccaaa gtgctgggat tacaagtgtg agccactgtg cctgactcag 16260 tttatttttt aaaatttttc ttcatttatt cttggcttct tccattcatt gttttgatca 16320 ctaactatgt gctcagcaca ttgctgagcc ttttgcatgc tctgctgggc attccccatt 16380 tgctcttccg gatccattat ccaccctgct ctgggacccc aaaaagctga tcttttatag 16440 atggtatcat ttgggcccca ttgattggtt cgtagttgag cctggccact tctctttcaa 16500 ctggtccctg gcagtcagta ccaacatttt agtcaggttt caaagaaatc tctagaccaa 16560 gctggacaga gggcttttcc agtgattcag tgattcccca agatctgaga atgtgaaact 16620 tggaaaaggg acacaaagac cggggatcct ttgagctggt tcaataatgg cagagcttta 16680 gagatatgct gctgagctcc ctgggtctgt ctcgctttct gccttctgaa ggcttgattg 16740 ttaacttctt cctgggtttc aattagaagc attagtgtcc ttcctggagt tgaattacct 16800 ggaaatttgc ctcctagatg tgtaaacttg ggaaagtatg atctcgtcaa gtttcagaca 16860 aaggcaaact aaaaagctag aactccagag agcataatag tgttttttgg gggcaaatta 16920 tttaatgaag tataacattc atacaggaag tacaaaaatc atcagtgtac aaaatctcca 16980 tgaattttca caatgtgtaa accattttcc tgttttatct gaccttacta agtcagggta 17040 taaattatta attttttttg aaacagggcc ttgctctgtg gtgcaggtta gggcagtggt 17100 gtgatcaccg ctcactgcag ccttgacttc ctgggctcag ccatcctgcc gcttcagcct 17160 cccgagtagc tgggactgca ggtgtgcgcc accacgtcca gctaattgtt taattttttg 17220 ttagagacgg ggtctcgctg tgttgcccag gctggtctag aactcctggg ctcaagcgat 17280 cagcccgcct cggcctccca aagtgctgag attataaggc gtgagccact gcaccctgct 17340 gagtatattt ttaaaaacac tttacccgag ggctgtggct cacacctgta atcccaacac 17400 tttgagaggc cgagacgggt ggatcacttg aggtcaggag ttcgagacta gcctgggcaa 17460 cacagctaaa ccctgtttat acaagatata caaaaattgg ctgggcgtgg tagcacgcgc 17520 ctgtagtccc agctcttggg aggctgaggc aggaggatcg cttgatcata gctcactttg 17580 aggctacagt gagctgtgat cgcgccattg cactccaacc tggatgacag agcgagaccc 17640 tgcctaaaaa aataaaaaaa aaaaggattt ttttctgttc agtggattca tttgaagcga 17700 gggccactgg tatttgaaat agatgacatc atctgccagc agaggcgtga ggcaacttga 17760 ggcggggtgt gggcctgacg tcatcacgca gcctcttcct ttccccgccc ccttctcttg 17820 gcgaacgagg cgtcagttta acacctccgt gaatccggaa gtatgctgtc aaaacaacca 17880 aaccacgggg ctgggggagg cggggcctca gtaggcgtct gcacgctagc tgaaatagag 17940 caaaatgccc gacttttggg ggcggggctc ctggcaacag cactctaggc gcaggcgcag 18000 aggcgacctc caggcagggc caggtgggag ggacggtggg gggtagggtc gcgcggcgcc 18060 ctctgcgcct gcgccccggc acgaggtggg gcggcgggcg tcagtacagt agagtgtgcg 18120 ccggggtggg gggcaacggt cagccgtcac cctgagacgg gcggcggcgg gatggcaaca 18180 gcctccgggg cctcggactt gtctggctcc ggagcgcccc cgcccggtgt gggagctcag 18240 gcggcggcgg ccgctgagga ggaggagcga gaggtggtgc gggtccgagt caaggtgagg 18300 ctggcggtga gtcggcccag ccgccgaggc atcccagggg agggggaggc ggtggctgtc 18360 ataggatgga gggcgggacc tgagatttcg gacataacct gagcggcgaa gcttgagggc 18420 caagtgatga tggcgagggg tagggagggc ctgagagcct gagagcgtta gcgacgtacc 18480 ttggggcgtg ggactgaaaa tagagggacg aggcgggggt ctatgggatg aatgggtgga 18540 gcttatagac aaaggggagg ggctatgggg ctggaggagg ggccgcagta gttgagggtg 18600 gggctctgag gaatgagaag gtgctggctc tggagtcagt caacccatgt gttgagagtg 18660 cacttatgtg caagttccca ctttgatgag ctgacaggct cgtgggtgga gacaactaaa 18720 gaaatgagat gcttcggaca ctaaaataat gaaaaaggtt atgaaatagg gagtcacgtt 18780 agccaaggtt gtacagggaa atccccagag gaggtattga aggagcagag acccgaataa 18840 aaggagtcag ccatgtgcat attagaaggg aagagtattc taggcagaag gaatagcaag 18900 ggcaaagact agaggatggg aatgagcctg gcatgttccc gtaggttcct gattgctgga 18960 gtggagagaa tgaggggaag agtggtagga ggtgaatcag agcgctaaga cagagacaga 19020 tcgccaaggg cctttggtgt gtatgctgag gaagaacgct gttgccatag ttccagtaaa 19080 caatgatggt ggctccgacc aaccagtggc actggcagtg ataagagggt ccacacatca 19140 cttcagtgta atagagctct aaggtagaag tttgacattc agaaaaaaga tgatgcctga 19200 gctgggcgtg aaccacgtga agaaagtggg agggatgttc cagacagggg atcagcacaa 19260 tcaatggcct ggagtcagga tggtttcaag gtaacttcta acagtttggt actactagag 19320 tgtaaagttc aaaaaacctg gtgagaggct ggctggggcc ccataggccc gcttgctggg 19380 actctagggt tgccattgaa gagattgaag caggggagtg ttgtaggtag atgtgttaga 19440 ttggttacag caccatagag gactgattta acaggagcca gactggacac ggtgattctg 19500 gcaaccatag ttgaagggat atagaagaag gattgggggc ctgaactctt gcagtagcct 19560 cctcctcact ggaccctgtg gtccagaaca cctgccttga tctggcccct ggcacctctc 19620 tgactttgcc ttctaccact ctgcacctca ctcttcagca tggtgatggg gcccctggtg 19680 gcctacccca tgtcttctct ccccagaaat gtgagagctt cttgccgcca gagttccgct 19740 cttttgctgt agatccccag atcacctcgc tcgacgtgtt gcagcacatc ctcatccgag 19800 cctttgattt gagtgggtga gtgggaagat gctggggact ggccagtggg ccaccgacct 19860 ctacagtggc tatctggcct ttgtttggta gggtttttgt ttattttact actacaaata 19920 atcccacagt gaacagccac gtatgcatgt cttggagcac agtagtctac ttttgtctgt 19980 ggttttgctt tctgcagttt cagttaccca tggtcaacct cagtctgcaa atattacata 20040 caataagata ttttgagaga gagagagaga ccacattcat attactttta ttacagttta 20100 cagacagtcc ccaacttaca ataactggac ttaggatttt tcaactttac aatggtgcaa 20160 aagcgatacg catttggtag aaactgtact gcaagtgccc agcgattctg cttttcactt 20220 tcagtacagt gttcaataaa ttacatgaaa tattcaacac tgttgtaaaa cagactctgt 20280 gttagatgat tttcccaact gtaggctaat gtgagcgttc tgagcacgtt taaggtaggc 20340 taggctaacc tgtgatgttt ggtaggataa atgtgttaaa tgcattttcc tttttatttc 20400 tttttttttt tttttttgag atggagtcta actgtcaccc aggctgcagt gcagtgacat 20460 ctcccaggtt caagtgattc tcctgtcaca gcctcccaag tagctgggac tacaggcatg 20520 caccactatg cccggataat tttttttttt tttttttttg agacggagtt ttgctcttgt 20580 cccccgggct gcagtgcagt ggcgcagtct cagctcactg caacctccgc ttcccgggtt 20640 caagtgattc tcctgcctca gcctcccaag tagctgggat tacaggcacg caccaccacg 20700 cctgctaatt tttgtatttt tattagagac aaggtttcac catgttggtc aggctagtct 20760 cgaacacctg acctcaagtt acctgtccac ctcggcctcc caaagtgcta ggattacagg 20820 tgtaagcccc cgcacccagt cccagatagt tttttgatct tctctttttt ttttttttgg 20880 agacagagtc tcactctgtc acttaggttg gagtgcagtg gtccgatgtt ggctcattgc 20940 agcctttgcc tcccgggttc aagtgattct catgcctcag cctccagagt agctgggatt 21000 acaggtgtgc accaccacac tcagctaatt ttcatgaggt tggtcaggct ggtctcaaac 21060 tcctgatctc aagtgatccg cccacctcgg cctcccaaag tgttaggatt acaggcacgt 21120 gagcctccgc acccggccaa ttttttgtat ctttagtaga gacagggttt cgccatgttg 21180 cccagggcag tctcaaactc ctgagctcaa gcaatccgcc cgcctcagcc tctcaaagtg 21240 ctgggattac aggtgagcca ctgcgcccag ccaaatgcat tgtcaactta cagtatttcc 21300 aacttacgat gagtttattg gtacataacc ctgtcataag tcaagaagca tctgtattgt 21360 cataattgtt ctattattgt taatctctta ctgtgcctaa tttatcaatt aaaccttatc 21420 ataggtatgt atgtatatga aaaaaaacat agtatatata gggcttggta ctatctgcag 21480 tttcaggcat ccactcgggg gggtcttgga atgtatcccc tgtagataaa gagggactac 21540 tgtatttgga aacatctagt cataggataa attcctagca gtggtattgc caggtaaaag 21600 ggtatttgct ttaaaaaaaa tttttttttt gagacagtct cattctgtcg tccaggctgg 21660 agtgcagtgg tgtgatctcg tctcattgca acctccacct cctgagttca agcaattctc 21720 ctgcctcggc ctcctgagta gctggtacta caggcgtgcg ccaccatgcc cggctaattt 21780 ttgtattttt agtagagatg gggtttcacc gtgttggcca ggatcgtctc gatctcctga 21840 cctcgtgatc cacccgcctc agcctcccaa agtgctggga ttacaggcat gagccaccgc 21900 acctggcctg ctttttgaac tattaatggg tgtttccaaa atgctctcca gacaggtttt 21960 atcaatttat gatctcagcc gggcgctgtg gctcatgcct gtaatcccag cactttggga 22020 ggctgaggca ggtggatcac gaggtcagga gatcaagacc atcctggcta acacggtgaa 22080 actccgtctc tactaaaaat acaaaaaatt ctccaggcgt ggtggtgggc gcctgtagtc 22140 ccagctactt gggaggctga ggcaggagaa tggcatgggc ccgggaggcg gagcttgcag 22200 cgagccgaga tcgcaccatt gcactccaga ctgggcgaca gagtgagact ccgtctcaaa 22260 aaaaaaaaaa aacgaattta tgatctcatc agcagcacat aaatgcctgt ttccctcaca 22320 ccctcgcaaa cattggttac tgtaaaactg caaaatttgc caatctgata gctgaaaagt 22380 ggtgtctctt gggggcagat gtgatagtca ttttgttgtg attttggagg aatacataca 22440 catggtaaga aattcaaaca gtacacaatt gttgggtatt taggatgttt ccatggttat 22500 gatgagcatc acgcaacaaa cttctttaca tagttgcaca agtatagctg aaaaattctt 22560 agttgttatt agactttctt acataaacat ttttgttgtg aaaaataaca aacacagatt 22620 gctttttttt tatgtagtaa gaaggctgct ttcttcccac ttctgtccca catctacccc 22680 agaggggacc aacttttttt tttttttttg agatggagtc ttgctctgtc acccaggttg 22740 gagtgcaatg ccacaatctt ggctcactgc aacctccacc tcccaggttc aagcgattct 22800 cctgcctcag cctcctgagt agctgggatt acaggcacct gccaccacac ccagctaatt 22860 ttttttgtat ttttagtaca gaaggggttt caccatgttg accaggctag tctcaaactc 22920 ctgacctcag gtgatccacc cacctcggcc tcccaaagtg cggagattat aggcgtgagc 22980 cactgcaccc ggccaacatt ttaccagttt ccaatgtgac ctccagatac aagcaggtgt 23040 gtacctgctt gtatgtgttt gtgtaacaaa gtgggtataa atgacctgat ctcaggctgc 23100 ccataatcct tggcacagta ccttgcacat agtaggaagt tgttttcaac gccttctata 23160 ttaccctcct tgttttggaa actgtccctg aggcctccag ggcaccaggg gccctgagag 23220 ctccctcgta tcccctgtcc aggaagaaga actttggcat cagctacctg ggccgggacc 23280 ggctaggaca ggaagtttac ctctcacttc tatctgactg ggacctcagc acagcctttg 23340 ccactgcctc caaaccttac ctgcaattgc gtgtagatat tcggccctcg gaggacagtg 23400 agtactcagt gcccccagga gcactgctct ggaacccctt taccccatag ggtgatgcta 23460 cccctcacag tacactccct catggtggga tgggtagcaa ggtatcctag ctatagatcc 23520 tggctcagcc actaggccac aatttcttca cttgtaaaga gataattgta tcttagaacc 23580 attgtgaggc cttgtatctt agaaccattg tgaggggaaa ttcatataaa atgcctggaa 23640 cagtgcatga ctgcataatg aaggctcaga aagtgttatc tctaataatg ataattatat 23700 tgtattatac tattataaca tataaccgag taatgtatgt aataattaga tataatgcag 23760 atttataata tagtataacg gtatagcttt agcattatgt atttcagtta taatacctaa 23820 atataacaat gcgtattata ataatgctag ttgtgtttat tcattcagtc attctgcacc 23880 catattcatt tgtttgtatt cttgctcact cattcatttg ttcccttgac ctctcagcca 23940 ctttttctct tctcatcttt gttcttccac tcttgcctat tctggtccct gcgagcacac 24000 agataaatta ggacgtggtc tcaaaatttg attacagacc atacattaga taattgtatc 24060 agtattaaat ttcctgggtg tgtgtcttag tcgttttgtg ctactataac agaataccac 24120 agactgagga atttgtaaag aagagaaatt tatttctcac agttttggag actgggaagt 24180 ccaagatcaa ggtgctggca ggttgtgtgt ctagtgaggg ctttcttgct gcatcctcac 24240 atgacagaag agcagaagag agtgaaccca caccctcaac ctctttataa gagcccaaat 24300 ccgctgggca cggtggctca tgcctgtagt cccagcactt tgggaggctg aggcaggcgg 24360 atcacctgaa gtcaggagtt cgagaccatc ctggccaaca tggtgaaacc ctgtctctac 24420 taaaaaaaat acaaaaatta gccgggtgta gtggcacatg cctataatcc cagctactcg 24480 ggaggctgag gcatgagaat cgcttgaacc cgaaaagcag aggttgcagt gagccaagat 24540 cttgccactg cactccagcc tgggtgacag agcgagactt catctcaaaa aaaaaaaaaa 24600 aaagaggctg agcacggtgg ctcacgcctg taatcccagc agtttaggag gccgaggcgg 24660 gcagatcaca aggtcaggag atcgagacca ccctggctaa cacggtgaaa ccctgtcttt 24720 actaaaaata caaaaaaata gccgggcgtg gtggcgggtg cctgtagtcc cagctactcg 24780 ggaggctgag gcaggagaat ggcatgaacc cgggaggcgg agcttgcagt gagccaagat 24840 cgcaccactg cactccagcc tgggcaacag agcaagactc catctcaaaa aataaataaa 24900 ataaaaaata aaaaaagagc cctaatccca tctgtgagag ctctaccctc aggacttaat 24960 cacctcttaa aggcccccac ctcttaatat gatcacattg gtaattaaat tgcaacacat 25020 gaatttggaa ggacacattc aaaccatagc agtgtggtag tggtatcata tctattgaag 25080 gaaaatatcc ttgttcttgg gaaagacaca gttaagtatg aaggggtaaa atgtcatgat 25140 gtctgcaaat aagttggcaa aaataatgtg tttatataca gagagagtga gataaagcaa 25200 atgtggccca aaaaaatgtt aatagaggat ctagatgaag tatgtatggg tgttcagtgt 25260 attcttttaa ctttattgta ggttcaaaat tgttttaaat agttgtggag tggaagatgt 25320 ggttcccagc ctcaggaaac tcatgtgccc atttgggatg agtcgagcac tttattgatg 25380 tcataataac atataactag ctaatgtgta gtgaacactt agggccattc tgtgcacata 25440 atattttttc actgaattgt caaaataatc ctatagagta gggacaatca ttttccccat 25500 attatagatg aggaaactga ggctcagaga ggtgacagga ctcgtcccag ttatacagac 25560 agtaagttga agagcaagat ttgaactcag gcagtggctg aactggctcc agagtccttg 25620 ttcttaacca tttaactcta caacattttg gacttgttaa aattggcagc tttgcaaaag 25680 agagacagag gagagagaga aacaagagtc agagggaaag atagtgacag agatgggcag 25740 gaagccaaat aggaaaagcc aggtagccag acacacagga acctctgcca ctgagtagcc 25800 atatgtgctt atgtcagtca cttaattccc tgggccttgt tttcctcacc tgttaaagag 25860 acacagtagc actatttcag gaaaaaaatc aaatctgcat ggctacgaaa catgtggaga 25920 aaaccccaag tgcatgagaa ctgggacgaa tgccagtaaa gcagagagac agacagaaag 25980 acacccagta gtctggcagg aatacatctt taaaaggtta tctttttagg ccaggcgccg 26040 tggctcacgc ctgtaatccc agcactttgg gaggccgagg cgggtggatc acctgaggtc 26100 aggagttcga gaccagcctg gccaaacatg gcgaaaccct gtctctacta aaaatacaga 26160 aattagccgg gcgtggtggt aggcgcctgt aatcccagct actcgggaga ctgaggcagg 26220 agaattgctt gagcctggga ggcggaggtt gcaatgatcc gagctcgtgc caccgcactc 26280 cagcctgagt gacagaacta gactccatct caaaaaaaaa aaaaaaaaag ccctctgtct 26340 tatttaccaa attcctgcac aacatcggtc tgtttctgaa ttcctgattc tcttacgttg 26400 atctatttat taaattataa gccaattcta tgttgtttta atcattgtag tagtttgttt 26460 tctgtttgtt tgtttggttt tgagggtttt ttttttgttt tttttttgag acagggtctc 26520 actctgtcat ccttgctgga gtgcagtggc ccaatctcag ctcactgcag cctccacctc 26580 ccaggctcaa gcaattgtcc cacgtcagcc tcctgagtag ctgggcctat aggcacatgc 26640 ccccatgccc agctaatttt tgtatttttt gtagagacag ggtttcgccg tgttgcccag 26700 gctggtcttg aactcctgga ctcaagcagt ctgcccgcct cagcctccca aagtgctggg 26760 attacaagca agagccaccg cacccagcct taatcattat agttttatga tatgttttca 26820 tgttttcctt tttaaaaaat tttcttgaat attcttgttc acttactgtt ctttttattt 26880 aataaatcag cttattattc cattaaaatc ctgacgggaa tttgattgga gtcatatttt 26940 taagagaaac taatctttca ttacccagta aatacattct tattaaaaat aaaagcattt 27000 taaataatgc tgaagtctcc tgggaacgct atgcctaatc tcaatcccct accctaccct 27060 ttttgccccg agggaatcgg tttgatgtgt aactttgcat gtcctttact tatttacact 27120 ccctacacac acatttatcc acatatgtga gtatattcat atttgcgtgt ctgtacacat 27180 aaacggtatg tgtttaacat aaggtattct acacattaat atgtaagtgt ccaatatatg 27240 gagctatcat tagacatatt aatggcattc tcatgatcat tttcatggct gtgaaagcaa 27300 cagacatgtt gggactgttt ggatggccca gtccctcttt ctgggaaaaa gccagtttct 27360 gtcacctcta cagttgggag attacaaagc ctagaccttt gaccaatttg tacttttccg 27420 atatgaatct tttttctttt tgagactctc tttgtcacca aggctggaat gcagtgacgc 27480 aaatatggcc cactgcagcc ttgacctcaa gctctcctcc tgcctcaggc tttcaagtag 27540 ctgggactac aggtgtgcac caccatgccc agctaatttt tgtatttttt gtagagacat 27600 ggttttgcca tgttggccag gctggtctcg aacttctgac ctcaagtgat ccacccacct 27660 cggcctctca aagtgtttgg attacaggcg ggagccaccg tgcccagccc ccaacctcct 27720 ttctatcata ggtactgcaa atatttttcc cagttgatct tttgtttttt ggctttgctt 27780 acgggatgga tctgttttgt cctatcaaaa ttaaacattt gattgcacgc ctacacagat 27840 atctatcttt ttctttatga tttctgagtt tctccttttt attgcaggtg gagggacaga 27900 gtttcactct cattgcccag gctggagtgc gatggcgcga tctcggctca ctgcaacctc 27960 cgcctcctgg gttcaagtga ttctcctgcc tcagcctccc aagtagctgg gattacaggc 28020 atgtgccact acacctggct acttttgtat ttttagtaga gatggagttt caccatgttg 28080 gtcaggctgg tatcgaattc ctgatctcaa gtgatccacc tgcctgggcc tcccaaagtg 28140 gtgggattac aggcatgagc cactgtgcct ggctgagttt ctcctattac tttggaacat 28200 gttccccatc cataagctta tacaaatatt ctatattttc ttctactatg cttattgttt 28260 tcttttttac atataaatct tttctctgtc agcattgtga taagcagacc tagctttaaa 28320 aaaatcaaga tagtcaatta tgccagcatc atttttttta atttaatttt tttttttgag 28380 acgaagtttt actcttatcg cccaggcagg agtgcagttg cacaatctca gctcactgca 28440 gccgccgtct cctgggttca agcaattctc ctgactcagc ctcccaaata gctgggatta 28500 caggtgcccg ccaccatgcc tagctaattt ttgtattttt agtagagatg aggttttgcc 28560 atgttggcca ggttggtgtc gaacttatga cctcaggtga tccacccact tcagcctccc 28620 aaagtgctga gattacaggc atgagccact gcgcccggcc tgccagcatc atttattaaa 28680 taatcacctt ttctgcagtg attcgaaatg ccacgtttgt cacatattca gtttccatat 28740 atacaagctt ggatttattt ctgggctttc tattgcattc taccaatggg ctctatttgt 28800 ctactgctgt gctaacacca tgttattttt atgacagtgg ttttgtggtc aaattttttt 28860 ttttttttga gatggagtct cgctctgtcg cccaggctgg agtgcagtgg cgcaatctca 28920 actcactgca agctccgcct cccgggttca cgccattctc ctgcctcagc ctccctagta 28980 gctgggacta caggcgataa gcttttgcca tcctcccact gttctttgtc ttaacttttt 29040 tttttttttt ggagatggag tcttgctctg tcgcccaggc tggagtgcag tggcacaatc 29100 ttggctcact gcaagctcca cctcctgggt tcacgccatt ctcctgcctc agtctcccaa 29160 gtagctggga ccacaggcgc tcgccaccac gcccggctaa tgttttgtat ttttagtaga 29220 ggcagggttt caccgtgtta gctaggatga tctcgatctc ctgacctcgt gatccaccca 29280 cctcggcctc ccaaagtgct gagattacag gcatgagcca ccgcgcccag cctgtcttag 29340 ctattcttaa atgtgaattc ttctatagaa accttaagat aattttatcc ggttccagga 29400 aaaaccccca ttcaatttct gactggcatt gcactgagtt tatatattaa tttagggttt 29460 gggaagtttg acaattttat gataaggaaa tgcgcgtatc atgaatatta tgtaatacca 29520 caagcagggt ctgggccagc agccaagcag cccacaatga aacacttgga tgtttcttca 29580 gggaaatgtg tgcatattca cactacgtgg gttatataaa gactatatat agtctcctgt 29640 cagttcagat caggttttgc tactaggtga gtttgtgttt gtagacattc tttgcctgtt 29700 ttttgtttgt ttgtttgttt gtttttttga gacactctgt tgccaggctg gagtgcagtg 29760 gcacaattcc ggctcactgc aacctctgcc tcccaggttc aagcgattct cctgcctcag 29820 cctcttgagt agctgagatt acaggcacgc gccaccacgc ccagctaatt tttgtatttt 29880 tagtagagac ggggtttcac catgttggcc aggacggtct cgatctcttg accttgtgat 29940 ccgcccgcct tgcttctcaa agtgctggga ttacaggtgt gagccactgc gcccggcctt 30000 ttttttcctt tttttgagag ggagtctcac attgttgccc aggctggagt gcagtggcgc 30060 gatctcagct cactgtaacc cctgcctccc aggttcaagc gattctcctt acctcagcct 30120 cccaagcagc tgggattaca ggcacctgcc accacacctg gctaattttt ttttgtattt 30180 tttagtagag atggggtttc accatgttgg ccaggctggt ctcaaccttg tgatccgccc 30240 acctcagcct cccaaagtgc tgggattaca gacgtgagcc accgcgcctg gcctctgcct 30300 gttttattag tgggattgag ggggtggttt ttttaatcag tataaaatgt ctctttgtgt 30360 taaatgcttt tggccttgag tgatgctttt tctgacattc tcatggctac tatttttttc 30420 tgtttgtgtt taccagatat acctttagga ttctttaatt tttaaccttt ttgtgtcacc 30480 tagttttagg tatgtctctc atacctctcg taaaaacgtc atagcagaat ttatgctttt 30540 taaggcaact gacagtgaaa tctttttttt ttctttttga cacgtagtct cgctctgtcg 30600 cccagactgg agtgcagtgg cacgatctca gctcgctgca acctctgcat cctgggttca 30660 agcaattctc ctccctcagc ctcccgagta gctgggatta caggcacaca ccatcatgcc 30720 cggctaattt tttttttttt ttttttgaga tggagtttcg ctctgtcgcc cagactggag 30780 tgcagtggca caatcttggc tcgctgcaac ctctgcatcc tgggttcaag caattctccc 30840 tcagcctccc gagtagctgg gattacaggc gctcaccatc acacctggct aattttttgt 30900 atttttagta gagacggggt ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc 30960 atgatctgcc tgcctcggcc tcccaaagtg ctgggattat agtcgtgagt cactgcaccc 31020 cgccccaaca gtgaaatctt taggccactt tttctccttt aatctctccc actttttctg 31080 gcctttaaaa tggagctttg gaacacttgt aattcttatt cgttttctgg tccctaaccc 31140 ttaacttcta gcttttgctt agacaacttt tttttttttt tgagatggag tcttgctctg 31200 ttgcccaggc tggagtgcta tggcacaatc tcagcttacc gcaacctcct cttcccaggt 31260 tcaagcaatt ctcctgcctc agcctcttga gtagctgggg taacagaagc gcaccaccac 31320 acccggctag tttttttata tttggtagag atggggtttc accatgttgg ccaggctggt 31380 cttgaactcc tgacctcaag tgatttgcct gcctcggctt cccaaagtgc tgggattaca 31440 ggcatgagcc accacaccca gccaattttt tttcttttta aattccgggt tatcattctg 31500 ttttcttact aacacactaa gtcacttatg tttcaggaat cctaatgtaa catataatat 31560 tacaaacccc caatcatgtt atcgttgtca ttttaactat aaatattaaa tatgtaatat 31620 atataatata atatataata tataaatatt accatttacc ttcccctttg tctctcccta 31680 tcttaagccc ttctagtcat gcaggagtca tttgctcaga gaacttcttt gttctcctcc 31740 aaaagtgcat gggttagatg tactctaatg gccaaaaatg tttttatttg gctgaataga 31800 tctgtactgt cttggctggg tgtggggccc ttggatctca ggtctttctt cttagtgctc 31860 cataggtgct gtgagctact gtcttattgc ctccagggtt gtgaagcaga agtctgttgc 31920 ttgtctgacc ttctttccat tgtaagcagc cgttttttgt ctctggaagc tgcaagagtt 31980 tttctttttc tttttttttt tttttttttt ttgaggcagg atctctattt cccaggcggg 32040 agtgcagtga cgtgatctca gctcactgca acctctgctt cccaggttca agcgatcctc 32100 ccacccacct cagcctcccg agtggcaggg actacaggtg tgcgccacca tgcccagcta 32160 atttttatat ttttgggtag agacagggtt ttatcatgtt cagcccaggc tggttttgaa 32220 ctctcgggct caagcaatcc gcccgccttg gcctcccaaa gtgctgggat taggctgggc 32280 atggtggctc atgcctgtaa tcccagcact ttgggagacc gaggtaggcg gatcacttga 32340 actcaggagt tcgagaccag cctggccaac atggtgaaac cccgtctcta ctaaaaatac 32400 aaaaatttgc caggtgttgt ggcgcacacc tgtagtccta gctacttggg aggctgagac 32460 aggagaatcg cttgaacccg ggaggcggag gttgcagtga gccaagatca cgccactgcg 32520 ctccagcctg ggcaacagag caagactctg cctcaaaaaa aaaaaattgc tgggattaca 32580 ggcatgagcc attgcgccca gtctaagagt ttttctttat tcttagaatt tgggcatttc 32640 gggctgggcg cagtggctca cgcctgtaat cccagcactt tgggaagctg aggcaggcgg 32700 atcacttgaa ctcaggagtt caagaccagc ctggccaatg tggcaaaacc ctgtctttac 32760 taaaaataca aaaattagca aaaattagcc gggcgtggtg gtatgcccct ggaatcccag 32820 ctacttggga ggctgaggca ggagaatggc ttgaacccag gaggcggagg ttgcagtgag 32880 ccgagatcat accattgtgc tccagtctgg gtgacagagc aagactccat ctcaaaaaaa 32940 aaaaaaaaaa aaggataggg ttggtggggg gcctgttgtg tgttgttagt taattaatcc 33000 tatctaagac ttggtgagcc attccttcat ctcagggaaa ttttctttca tacttgttta 33060 attctgacat ctccacctga tcccttttct ccccctgcat ttcctattat ttccatattt 33120 ggtctcctgg acttggcatc caggtctctc tactttttca ctcaaatcat tgaaccttag 33180 ctccatgcct tgcagtggtt cttctgttca gactttcaga ccattactga tttttcataa 33240 tgtgaccttc ttcattttac ctgttaagtg ttttaatgct ctgattaatg ttttagaaag 33300 accattctgg cagctgttgg gagagattgg agaggaatac agaggaagtg aggactggtt 33360 aggaggcagt ttcaggtgag agatatggtg gctcagacag ggtgagaaga tggagatgag 33420 agaacaggta ggatggagga atgctttaca tgcagtagcc gtaggacttg gcggtggttt 33480 ggacctggga gttaagagag tgggaggggg acaaggatgt ctctcaggtt tctggtctat 33540 taaacaactg aacagataga gatgctgttt gttgagatga ggagtagagg aggaggccat 33600 gtctagagtg gatcttgggc tcctctcttt ggacccctta ggtttgcagt accccatgag 33660 acatccaggg aaaagcagtg acatgcaaac atggcctagg gtttgttccc cccctcagct 33720 ctatgggaaa attgggctcc atgggaatgc tgtttaggga tggcatttgc ttgcaaatga 33780 cagtggctta aacagataga agttgattgg tttcacacaa aagagtttga aagttagcca 33840 cttgggccgg atgcagtggc tcacgcctgt aatcccagca ctttgggagg ccaaggtgaa 33900 gggggcctgc ccctccacac ttgtgggtat ttctcgttag gtggagacga gagattgaga 33960 aaagaaataa gacacagaga caaagtatag agaaagaaca gtgggcccag ggtaccggca 34020 cactcagcat gcgaggacct gcaccagcgc cggtctctga gttccctcag tatttattga 34080 tcactatttt tactatcttg gcaaggggag tgtggcaggg caacagagtg ttggtgggga 34140 gaaggtcagt agggaaacat gtgagcaaag gaatctgtat catgaataag ttcaaggaaa 34200 ggtactgtgc ctggatgtgc atgtaggcta gatttatgtt tcactttaca caaatatctc 34260 agtgtagcaa agagtaacag agcagtattg ctgccagcat atctcgcctc cagccacggg 34320 gcaattttct cctatctcag aatagaacga atggtcggct ttacaccgag acattccatt 34380 cccagggaca agcaggagac agaagccttc ctcttatctc aactgcaaag aggactccct 34440 ctttcactac tcctcctcag catagaccct ttatgcgtgt cgggctgggg gatgtaaggt 34500 ctttcctttc ccacgaggcc atatatcagg ctgtctcagt gaggggaaac tttggacaat 34560 acccaggctt tcttgggcag agttccctgt ggctttccac agtgcatttt gtccctggtt 34620 aatagagaat ggagaatggc gatgactttt accaagcata ctgcctgcaa acatattgtt 34680 aacaaggcac atcctgcata gccctaaatc cattaaacct tgattcaata cagcacgttt 34740 ctgtgagcac atggttgggg ctaaagttac atacagatta acagcatctc aaaccagaac 34800 aatttttctt agtacagatc aaaatggagt ttcttacatc ttccttttct gcatagacac 34860 agtaacaatc tgatctctct ttcttttccc cacataaggc gggtggatca cctgaggtca 34920 ggagttggag accagcctgg caaaccccat ctctactaaa aatacaaaaa attagccagg 34980 cgtggtggca ggcacctgta atcccagcta ctcgggaggc tgtggcagga gaattggttg 35040 aacctgggag gcagaggttg cagtgagcga ggatcacacc attgcacgcc agtgtgggtg 35100 acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aagccagcca ctggacattg 35160 ccattgttgg cttagtagcc ctctcgtatc agggctgtag gagaggatct ctgaagatcc 35220 tctcgaacct actctcagat ggccactgct gcttcaacca ccacatctta tgtgaggtgg 35280 gaagaaagaa tgcggggcaa aatgaaaaag aaagagaaac ggtcaggtgc agtggctcac 35340 acctgtaatc ccaacacttt gggaggccaa ggcaggagga tctcttgagc ccaggagttc 35400 aagaccatag gcaatatagt aagatcccat ctctaccaaa aaaaaaaaaa atcatccacg 35460 catggtggca cacgcctgta agccccagct actcaggagg ttgaggcaag aggatcgttt 35520 gagcccagga gtttgaggct gcagtgagct atgatcgcac cactgcactc cagccttggg 35580 ggacagagca agactgtctc aaaaaaagaa aaaaaagatg cctgtaatcc tagcactttg 35640 ggaggccaag gcgggctgat cacctgaggt caggagttcg agaccggcct gggcaacata 35700 gcgaaacctc atctctacta aaaatacaaa aattaggcca ggtgtggtgg ctcatgcctg 35760 taatcccagt accttgggag gccgaggcag gtggatcacc tgaggtcggg agttcgagac 35820 cagcctgacc aacatggaga caccccgtct ctactaaaaa tataaaattc accaggcatg 35880 gtggtacatg cttgtactcc cagctactcg ggaggctgag gcaggagaat cacttgaacc 35940 caggaggtgg atgttgcagt gagccgagat cccgtcattg tactccagcc tgggcaacaa 36000 gagtgaaact ccgcctcaaa aaaaaaaaaa aaattagctg gacctggtgg caggcacctg 36060 taatcccagc tacttgggag gcttaggcag gagaactgct tgaacccaaa aggtggagtt 36120 tgtagtgagc caagattgca ccactgcact ccagcctggg cgacagagtg agactccatc 36180 tcaaaaaaaa aagaaaaaag aggctgggtg cagtggctca cgcctataat cccagcactt 36240 tgggtaggcc aaggcgagtg gatcacgtga ggtcaggagt tcaagaccag cctgaccaac 36300 atggtgaaac tccgtctcta ctaaaaatac aaaaattagc tgggcatggt ggcaggcacc 36360 tgtaatccca gctactcggg aggctgaggc aggagaatca cttgaaacca ggaggcagag 36420 tttgcagtga gctacgttca caccactgca ttccaccctc ggttacagag tgagactccg 36480 tctccaaaaa aaaaaaaaaa aaagcatata cggcatacct gttccacttt tgcacaaata 36540 ttttatttct aaagtatgtc tgggctctgg actagggtga atgaagttca gatcccagcc 36600 ctactatttc ctggctgtag aatcttggtc acttactatt tgttccaaac ctttttgtca 36660 tcgtctgtaa aatgagaatg gtaatattag cgtgcactgt ttgtgggagg aggactggca 36720 aaaatatgag agtaggagtt tgggctcttg agcttgggcc tggccttcaa atttccactc 36780 tttcactcac tagctaaggg gccttgggca agtaccttat catgactgtg cctgtttcct 36840 caaagagagt catggtagta gtagtactca accgatagga ctgaagtgac tattgcatga 36900 gtcagtattg gcaaagaatt cagaatagtt cctggcatac agcactgtgg aagcattagc 36960 tagtattatt atttcttata ttgctgttga gcgcttgtcc tagtgcttgg cacatagtaa 37020 ctgctcaata aatattactt tatatcatta aaatattaga ggctgcccag ccagttcctg 37080 agacatctac tacaaaagaa ttgttcatgg tttgattttg ttttttacat gatttggatg 37140 atacaggaag agggactggg agttgtttgt tcccctgcag gtagcccggc ttcagtagaa 37200 ggagaggaag ccggccctga ggtctgggtt atcatcccca ttcttatagc actttgttct 37260 gtttgcccag gcccattgct agaagactgg gacataatca gccccaaaga tgtcattggc 37320 tccgacgtgt tgctggctga gaaacggtca tcactgacga ctgccgccct gccctttaca 37380 cagtccatcc tcactcaggt gttttcaggg accctaggga cccagctgtg gttggagggc 37440 agagccttcc tggcaccctg gttctgagca tgctggttgg catctgcccc tagtccacac 37500 agctgatggt ggcctccctc cctcctcata ggtgggccgt accttgtcta aggtccaaca 37560 agtgctgagc tggtcgtatg gggaagatgt caagcccttc aagccacccc tgagcgatgc 37620 tgagtttcac acgtacctga accacgaggg ccagctctcc cgacccgagg agttgcgcct 37680 gcggatctat catggcggtg tggagccctc gctgcgaaag gtgagcatcc tcagtcatct 37740 gttgggtcca tcactgctgc actcattaac agctcctgag acacatgcag tcagccacac 37800 tgctgtgggc aagggtggag atgttacagg gcacgaagtt ctctttaagg aggggcgagc 37860 agtcggaggc ctagcagact tagaaggaag acagaggccc aaggggggtg ggtgggtggc 37920 aactgataga cattggggta tggtttatct ggagaactcc agcctcatcc ctttcacccc 37980 tgggcaggtg gtgtggcggt acctgctgaa cgtgtatcca gatggactga caggccgaga 38040 gcggatggac tacatgaaac gcaagagccg cgagtatgag cagctcaaga gcgagtgggc 38100 ccagcgagcg aaccctgagg acctggaatt catccgcagc acggtcctca aggatgtact 38160 gcgcactgac cgggcccacc cctactatgc ggggcctgag gatggcccac atctacgggc 38220 gctgcacgac ctgctcacca cctatgccgt tacccaccca caggtgtcct actgccaggg 38280 catgagtgac cttgcctcac ccatcctcgc tgtcatggac catgagggcc atgcctttgt 38340 ttgcttttgt ggcatcatga aacgcctggc cgccaacttc caccctgacg gccgcgccat 38400 ggccaccaag tttgcacact tgaagctgtt gctgcgacac gctgaccctg acttttatca 38460 atacctgcaa gaggcaggcg ctgatgacct cttcttctgt taccgctggc tgctgctgga 38520 actcaagcgt gagttcgcct tcgacgatgc cctccgcatg cttgaggtca cttggagttc 38580 gctgccccct gatcctcctg aacatgaggt agagctggtt ggacccccca gccaagtggc 38640 agacgctggt tttggtggcc acagggggtg gcccgtgcga cagaggcaca tgctgaggcc 38700 tgctggtgga ggaggtagta cctttgaaga tgctgttgac cacctggcca cagccagtca 38760 ggggcctggt ggtggggggc gtctcctgag acaggccagc ttggatggcc tccagcaact 38820 cagggataac atgggctcca ggagggaccc tctggtccag ctgccccacc cagctgccct 38880 tatcagctcc aagtccctct ctgagccttt attgaactcc ccagacccac tgctctcctc 38940 cttttcccac cctgattccc catcttcctc atctccacca tccacccagg aggcctctcc 39000 cactggtgat atggctgtag gatccccctt gatgcaagag gtaggctccc cgaaagaccc 39060 tggaaagtcc ctgccacctg taccaccaat gggcctgccc ccaccccagg agtttggccg 39120 ggggaaccca ttcatgctgt tcctctgcct ggccatcctg ctggagcacc gcgaccacat 39180 catgcgcaat gggctggatt ataatgagct ggccatgcac tttgaccgcc ttgtgcgaaa 39240 acaccacctg gggcgcgtcc tgcgccgggc tagggctctc tttgctgatt acctgcagtc 39300 agaggtgtgg gactcagagg agggggctga ggccacagcc gcatcttgat caggctttct 39360 caagccctcc atcggcccca ccagatctcc attctttgcc atgagggcca acacatgaga 39420 ccccacctcc ctccctgcct gccagcccta gacttgttgg agcatagagc ccttcctccc 39480 caggcctaag tatgtggagc tctgctttgg cactgccccg cagaggccac gcctatttat 39540 tctgtttctg ttgttttgtt tttaacaact atactttgca cacatgaagg tcactgtggt 39600 ttgtgtgttt ctctgcctcc tccctgggtt ttgctgtaga tggagtcctc aggggccctt 39660 tacctgatgg aggggaaata cttcacttgg tggagagagg ctccagcttc ccccttgtga 39720 tggggagagt ggatgctgac aatcagttcc caaaggtgag cccaggtgga gcactgcttg 39780 aggaaggcct gagtctgttt ttttggtaca tccatcggcc tgtaagggtc tgtattatgg 39840 ctgtgaatat atgttttcag gacagccccc tggatgagag ataagagagt tcctggctca 39900 aaaaaggaca agattcttta ctgagattgg gaagtatggg ctacttagaa acgttggagc 39960 agccacccct ggcattccac atgtcaccat ttctaggatc ttggcctctc tgtgaggttt 40020 atgcaccaat gctggcagcc ctgggcaggg gcctcggcct cctttttgtt ttccacttca 40080 gacaggtacc gtgcagatgt taacaaggtt tgagcgaggt gcatctcaca caagtgtgaa 40140 agcccaatca tcacattgtt gaattacaaa aggatctagg gctcctattc ttgtcacttg 40200 ctttggagcc agtttgaaag actggcctag cccatgccta gcggccctaa actgggattc 40260 cagctcacag cacctgtctt aaccatttca gcagtagaaa ccacttattt accttctcca 40320 tctcactaat atggacaaac aacaagcact gataaaacgc aggccctaat agaattcact 40380 tcgttatttg gaggataatg atc 40403 <210> 29 <211> 2576 <212> DNA <213> Homo sapiens <400> 29 aattcttcca aaacaaaact agaactgcaa aagcacctga cgacattaac caatcaggag 60 caggcgacta tttttgaaga ggttcagaaa ttgagaccga gaaatgagca gcgagagaat 120 gaattgatta tttcttttct gagatgttta tatgaagaga aacagaaaga acacatccat 180 attggggaga tgaagcagac atcgcagatg gcagcagaga atattggaag tgaattacca 240 cccagtgcca ctcgatttag gctagatatg ctgaaaaaca aagcaaagag atctttaaca 300 gagtctttag aaagtatttt gtcccggggt aataaagcca gaggcctgca ggaacactcc 360 atcagtgtgg atctggatag ctccctgtct agtacattaa gtaacaccag caaagagcca 420 tctgtgtgtg aaaaggaggc cttgcccatc tctgagagct cctttaagct cctcggctcc 480 tcggaggacc tgtccagtga ctcggagagt catctcccag aagagccagc tccgctgtcg 540 ccccagcagg ccttcaggag gcgagcaaac accctgagtc acttccccat cgaatgccag 600 gaacctccac aacctgcccg ggggtccccg ggggtttcgc aaaggaaact tatgaggtat 660 cactcagtga gcacagagac gcctcatgaa cgaaaggact ttgaatccaa agcaaaccat 720 cttggtgatt ctggtgggac tcctgtgaag acccggaggc attcctggag gcagcagata 780 ttcctccgag tagccacccc gcagaaggcg tgcgattctt ccagcagata tgaagattat 840 tcagagctgg gagagcttcc cccacgatct cctttagaac cagtttgtga agatgggccc 900 tttggccccc caccagagga aaagaaaagg acatctcgtg agctccgaga gctgtggcaa 960 aaggctattc ttcaacagat actgctgctt agaatggaga aggaaaatca gaagctccaa 1020 gcctctgaaa atgatttgct gaacaagcgc ctgaagctcg attatgaaga aattactccc 1080 tgtcttaaag aagtaactac agtgtgggaa aagatgctta gcactccagg aagatcaaaa 1140 attaagtttg acatggaaaa aatgcactcg gctgttgggc aaggtgtgcc acgtcatcac 1200 cgaggtgaaa tctggaaatt tctagctgag caattccacc ttaaacacca gtttcccagc 1260 aaacagcagc caaaggatgt gccatacaaa gaactcttaa agcagctgac ttcccagcag 1320 catgcgattc ttattgacct tgggcgaacc tttcctacac acccatactt ctctgcccag 1380 cttggagcag gacagctatc gctttacaac attttgaagg cctactcact tctagaccag 1440 gaagtgggat attgccaagg tctcagcttt gtagcaggca ttttgcttct tcatatgagt 1500 gaggaagagg cgtttaaaat gctcaagttt ctgatgtttg acatggggct gcggaaacag 1560 tatcggccag acatgattat tttacagatc cagatgtacc agctctcgag gttgcttcat 1620 gattaccaca gagacctcta caatcacctg gaggagcacg agatcggccc cagcctctac 1680 gctgccccct ggttcctcac catgtttgcc tcacagttcc cgctgggatt cgtagccaga 1740 gtctttgata tgatttttct tcagggaaca gaggtcatat ttaaagtggc tttaagtctg 1800 ttgggaagcc ataagccctt gattctgcag catgaaaacc tagaaaccat agttgacttt 1860 ataaaaagca cgctacccaa ccttggcttg gtacagatgg aaaagaccat caatcaggta 1920 tttgaaatgg acatcgctaa acagttacaa gcttatgaag ttgagtacca cgtccttcaa 1980 gaagaactta tcgattcctc tcctctcagt gacaaccaaa gaatggataa attagagaaa 2040 accaacagca gcttacgcaa acagaacctt gacctccttg aacagttgca ggtggcaaat 2100 ggtaggatcc aaagccttga ggccaccatt gagaagctcc tgagcagtga gagcaagctg 2160 aagcaggcca tgcttacctt agaactggag cggtcggccc tgctgcagac ggtggaggag 2220 ctgcggcggc ggagcgcaga gcccagcgac cgggagcctg agtgcacgca gcccgagccc 2280 acgggcgact gacagctctg caggagagat tgcaacacca tcccacactg tccaggcctt 2340 aactgagagg gacagaagac gctggaagga gagaaggaag cgggaagtgt gcttctcagg 2400 gaggaaaccg gcttgccagc aagtagattc ttacgaactc caacttgcaa ttcagggggc 2460 atgtcccagt gttttttttg ttgtttttag atactaaatc gtcccttctc cagtcctgat 2520 tactgtacac agtagcttta gatggcgtgg acgtgaataa atgcaactta tgtttt 2576 <210> 30 <211> 479 <212> DNA <213> Homo sapiens <400> 30 tcaagccatg ggcctctgcg aaggcgccgg cgtgcccacg gctaagaaac ttcctctttc 60 tgctcccggg aacgaaggct gtagcagaga aggccttcaa gtttcgagac ccagttccag 120 ccgcagctga gcactggtga ccttgaatta agtctaatgt tgggattgga agacgcttca 180 gacatccgct gccgccctgg gcaagcgacc agctcaaggt taccccacag ggacgtgctc 240 tggtcccacg gtccagtgct cttttgtcgg ttagttttgt catttgtaaa ataggaacag 300 tagatagtgg taggaaagtg gttgtgaaaa cttaatagaa agctaagcgc cttggtcggg 360 cgcagtggca tgtcacccct gcaattctat cactttggga ggctgaggcg ggcggatcgt 420 ttgagcccag gaattcgaaa ccagtctggg caatatgaaa ccccatctct gcaaataaa 479 <210> 31 <211> 616 <212> DNA <213> Homo sapiens <400> 31 atgcattctg caagccaccc tggggtgcag ctgagctaga catgggacgg cgagacgccc 60 agctcctggc agcgctcctc gtcctggggc tatgtgccct ggcggggagt gagaaaccct 120 ccccctgcca gtgctccagg ctgagccccc ataacaggac gaactgcggc ttccctggaa 180 tcaccagtga ccagtgtttt gacaatggat gctgtttcga ctccagtgtc actggggtcc 240 cctggtgttt ccaccccctc ccaaagcaag agtcggatca gtgcgtcatg gaggtctcag 300 accgaagaaa ctgtggctac ccgggcatca gccccgagga atgcgcctct cggaagtgct 360 gcttctccaa cttcatcttt gaagtgccct ggtgcttctt cccgaagtct gtggaagact 420 gccattacta agagaggctg gttccagagg atgcatctgg ctcaccgggt gttccgaaac 480 caaagaagaa acttcgcctt atcagcttca tacttcatga aatcctgggt tttcttaacc 540 atcttttcct cattttcaat ggtttaacat ataatttctt taaataaaac ccttaaaatc 600 tgctaaaaaa aaaaaa 616 <210> 32 <211> 1211 <212> DNA <213> Homo sapiens <400> 32 agtcctactg gtgtctgctc cggggaaagt catccttcat ggagaacatg ccgtggtaca 60 tggcaaggta gcactggctg tatccttgaa cttgagaaca ttcctccggc ttcaacccca 120 cagcaatggg aaagtggacc tcagcttacc caacattggt atcaagcggg cctgggatgt 180 ggccaggctt cagtcactgg acacaagctt tctggggtct cactctgtta tgcagcctgg 240 agtacagtgg tgcgaccaca gctcactgtt tcttcaacct cctgggctca agcgatcctc 300 ctgcctcagc cttctgagca gctgggacca cagagcaagg tgatgtcaca acacccacct 360 cagagcaagt ggagaagcta aaggaggttg caggcttgcc tgacgactgt gctgtcaccg 420 agcgcctggc tgtgctggcc tttctttact tatacctgtc catctgccgg aagcagaggg 480 ccctgccgag cctggatatc gtagtgtggt cggagctgcc ccccggggcg ggcttgggct 540 ccagcgccgc ctactcggtg tgtctggcag cagccctcct gactgtgtgc gaggagatcc 600 caaacccgct gaaggacggg gattgcgtca acaggtggac caaggaggat ttggagctaa 660 ttaacaagtg ggccttccaa ggggagagaa tgattcacgg gaacccctcc ggagtggaca 720 atgctgtcag cacctgggga ggagccctcc gataccatca agggaagatt tcatccttaa 780 agagttccca gagatcgtgg cccccctcct gacctcaaca gatgccatct ccctggagtg 840 tgagcgcgtg ctgggagaga tgggggaagc cccagccccg gagcagtacc tcgtgctgga 900 agagctcatt gacatgaacc agcaccatct gaatgccctc ggcgtgggcc acgcctctct 960 ggaccagctc tgccaggtga ccagggcccg cggacttcac agcaagctga ctggcgcagg 1020 cggtggtggc tgtggcatca cactcctcaa gccagggctg gagcagccag aagtggaggc 1080 cacgaagcag gccctgacca gctgtggctt tgactgcttg gaaaccagca tcggtgcccc 1140 cggcgtctcc atccactcag ccacctccct ggacagccga gtccagcaag ccctggatgg 1200 cctctgagag g 1211 <210> 33 <211> 1445 <212> DNA <213> Homo sapiens <400> 33 gtccggagga ggcgttgtga ggtgagcttt ttcagaagcg cgatcccagg acacgtcggg 60 aagcaagcat ccccagagct gcttggaaag aggaccaaag acgtctaaaa agtcatttgg 120 aaatatctct aaatatttgt taccatgtat aagctgctaa agagaaattg ggcccaacaa 180 aactaattga ataattgagg cagatttgtg tgtatcatca aattctatcc agaagttgaa 240 gaatctgaat ttaaagattg tgtgcattta ataagaggat gacctttcag tttaatttca 300 ctatagaaga ccatctggaa aatgaattaa cacccattag agatggagct ttgaccctgg 360 attcctcaaa agagctgtca gtctcagaaa gtcaaaaagg agaagagagg gacagaaaat 420 gttctgcaga acaatttgac ttgcctcagg atcacttgtg ggaacataag tcaatggaaa 480 atgcagctcc ctctcaagac acagacagtc cactcagtgc agccagcagt tcaaggaact 540 tggagccaca tggaaaacag ccctccttga gagctgccaa agagcatgct atgcctaaag 600 atttaaagaa gatgttagaa aataaagtca tagaaacatt accaggtttc cagcatgtta 660 agttatcagt agtgaaaacc atcttgttga aagagaactt ccctggagaa aacatagttt 720 caaaaagctt ttcttctcac tctgatctga ttacaggtgt ttatgaggga ggcttaaaaa 780 tctgggaatg tacctttgac ctcctggctt atttcacaaa ggccaaagtg aaatttgctg 840 ggaaaaaagt cttggatctt ggttgtggat caggtttact aggtataact gcattcaagg 900 gagggtccaa agaaattcac tttcaagatt ataacagtat ggtgattgat gaagtaacct 960 tacctaatgt agtagctaac tccactttgg aagatgaaga aaatgatgta aatgagccag 1020 atgtgaaaag atgcaggaaa ccaaaagtaa cacaactata taaatgccga tttttttctg 1080 gtgagtggtc tgagttttgt aagcttgtac taagtagtga aaaacttttt gtaaaatatg 1140 atctcattct cacctcagaa accatttaca acccagatta ttatagtaat ttgcaccaga 1200 ctttccttag actgttaagt aaaaatggac gtgtactttt ggccagcaaa gcacattatt 1260 ttggtgtagg tggaggtgtt catctctttc agaagtttgt agaagaaaga gatgttttta 1320 agaccagaat actcaaaata attgatgaag gattgaagag gttcataatt gaaataactt 1380 ttaagtttcc tggttaatta acattcactg agtatccaaa atgaaataaa cagaaggacc 1440 aaaaa 1445 <210> 34 <211> 3629 <212> DNA <213> Homo sapiens <400> 34 gagagagaga gaactagtct tgagtttttt tttttttttt ttttccaaga tgccgggcac 60 tgcacggctt ttatcagttt ttattacatc aggtcaagga aacaaatgga atctatccac 120 atggtcctgc ctcgttgggc atatattcta aacatacatc cattttcata cccaatgaga 180 aagaactcaa ttccaaagga tctcaccttt cacaaaattc tacccttaag atcctaaaac 240 agtcatatca ctgtgcacaa aatttttggc agtcacaagc tctaacacaa agcagagctt 300 aaaaacaaat ggagaatata atcagtgttc aaatgcaccc tcactgggtg ggtcagactg 360 catgaggcag tgtggctgtg tggagggaga ggtccggacc tgtggcaaac tgctgctcct 420 gccaggaggc taccaaagcc aaggctctta acatattgag gttcctcagc tgccccagtg 480 cctatatctc taacaacagt aaacagtgaa atacctgcag gcaaccatgt ctaaataaag 540 agataaatat ttgaatcttc aagaagtggc caacttcaga aaggcatctc ttggcaccct 600 agaggagact gggatgaaag ttgtaccgga gactggagaa gagcccgatg tgtttcacga 660 ggttcggctc cactacatag gccctctctc ccttggccct caacagcgag tacagtgcca 720 tgtccttgcc aaagcccttg tggcagtaca cttgggacag gtaggtgagg gtccggcggg 780 ccgcaggtgc cgggaagagc atggctgggg tgcaacactg agaggcagga accacactgt 840 acagggaagg actcagccgc cgcagttcca ggaaatagtg ccgacccacc agctccacca 900 gacccatgct atacagggag aagaagagca ttacaggcca gctaaaccct gggcggctgg 960 caaacctcat gtatatccag gttagtaagg gccccagcaa catgcctaca ccaacccatt 1020 ccaggatccg catgggctct ggattgatgt agtgctggag cctctcgggg tgatacagct 1080 tgagataaag ggcatctctg agatgtggct cagagaagcg agcccgcaga aggtgctcca 1140 agactgggaa gatctgctct tctggtacag catcgtcttc taccatcagg acgtagtctg 1200 ggttgtaggt ctgcagggat gactccaggc aatagacata gtcctgcttc tctttctcaa 1260 acgagttggt cgaagggtca tcaccataat catcctcagt gccctcatag cgattggcca 1320 cagggacata cttggagagc aacttggcat caaaatggct cacactacgc tccacgttgc 1380 acaggaagag ttggtgcccc tcgcactggg ggccacattg ctgaagaagc cggtggaact 1440 gggacacaac ctgcaggacg tagtggaagc caggctgcct gtccacagtg atgatggtga 1500 tcaccagcca gggccggggg gtggcctgcc agacaatggg cactgagcca ttggcagagg 1560 gaagctcctc aaaatagtgg agggcagcct caccctcttt caagctttgc tgcaggaact 1620 cttggctcat ttggttcaga tgccaatggc gcagatagaa gtaagagtgt agaagtcggt 1680 gacaggccag gggggccagc aggccaaacg tcaccactgt taggatgaag agctggacag 1740 cagtgctgcc ccaggacagt cgccgcagcc tccggaggag catggcagct ggagaggttg 1800 aagtgctcat gaggtcaact tttgttcatg tctggtccca agaaaaaacc atcctggaac 1860 tcaggccaga gtcatcagaa atcaaacccg gttggggcga ccagctcggt cccctgcgcg 1920 cgccgagggc cgcctctggt attgcccagg ctggctagct catcccggtg gaggcgccat 1980 ctccgctcga ctcttagctt gtcggggacg gtaaccggga cccggtgtct gctcctgtcg 2040 ccttcgcctc ctaatcccta gccactatgc gtgagtgcat ctccatccac gttggccagg 2100 ctggtgtcca gattggcaat gcctgctggg agctctactg cctggaacac ggcatccagc 2160 ccgatggcca gatgccaagt gacaagacca ttgggggagg agatgactcc ttcaacacct 2220 tcttcagtga gacgggcgct ggcaagcacg tgccccgggc tgtgtttgta gacttggaac 2280 ccacagtcat tgatgaagtt cgcactggca cctaccgcca gctcttccac cctgagcagc 2340 tcatcacagg caaggaagat gctgccaata actatgcccg agggcactac accattggca 2400 aggagatcat tgaccttgtg ttggaccgaa ttcgcaagct ggctgaccag tgcaccggtc 2460 ttcagggctt cttggttttc cacagctttg gtgggggaac tggttctggg ttcacctccc 2520 tgctcatgga acgtctctca gttgattatg gcaagaagtc caagctggag ttctccattt 2580 acccagcacc ccaggtttcc acagctgtag ttgagcccta caactccatc ctcaccaccc 2640 acaccaccct ggagcactct gattgtgcct tcatggtaga caatgaggcc atctatgaca 2700 tctgtcgtag aaacctcgat atcgagcgcc caacctacac taaccttaac cgccttatta 2760 gccagattgt gtcctccatc actgcttccc tgagatttga tggagccctg aatgttgacc 2820 tgacagaatt ccagaccaac ctggtgccct acccccgcat ccacttccct ctggccacat 2880 atgcccctgt catctctgct gagaaagcct accatgaaca gctttctgta gcagagatca 2940 ccaatgcttg ctttgagcca gccaaccaga tggtgaaatg tgaccctcgc catggtaaat 3000 acatggcttg ctgcctgttg taccgtggtg acgtggttcc caaagatgtc aatgctgcca 3060 ttgccaccat caaaaccaag cgcagcatcc agtttgtgga ttggtgcccc actggcttca 3120 aggttggcat caactaccag cctcccactg tggtgcctgg tggagacctg gccaaggtac 3180 agagagctgt gtgcatgctg agcaacacca cagccattgc tgaggcctgg gctcgcctgg 3240 accacaagtt tgacctgatg tatgccaagc gtgcctttgt tcactggtac gtgggtgagg 3300 ggatggagga aggcgagttt tcagaggccc gtgaagatat ggctgccctt gagaaggatt 3360 atgaggaggt tggtgtggat tctgttgaag gagagggtga ggaagaagga gaggaatact 3420 aattatccat tccttttggc cctgcagcat gtcatgctcc cagaatttca gcttcagctt 3480 aactgacaga cgttaaagct ttctggttag attgttttca cttggtgatc atgtcttttc 3540 catgtgtacc tgtaatattt ttccatcata tctcaaagta aagtcattaa catcaaaaaa 3600 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 3629 <210> 35 <211> 4225 <212> DNA <213> Homo sapiens <400> 35 gcagagggtg cggcccagag gaggccgcgg gccgggaagg gccgggcggg acgggaaacg 60 ttagggcagc ggcccccggg gtgagggggc cgagcggacg ggcagggccc cgaggcgaac 120 tctgcccgga tgaggaacaa agcagtgggg caggcgcgtg cgcccccagc gcagctggca 180 ggttgggcag cccccttccc gaagcttctg gacggaaggc cccaggtgtt ccccgagatg 240 ccccaacccg tggcggggtg cacggccacc ggccctcggg agaagttggg cggccccggg 300 cgaccccggg gacgagtggc cgcgtcggtg cagcggttgt gagcaagatg tggtagcacg 360 tgaccctgga acgcaaaccc tgatgcctgt tccccaccac ccgagcgctc ctttctctga 420 tatttggccc caagccgatg catcacagga tgaatgaaat gaacctgagt ccagtgggga 480 tggagcagct gacttcatcc tctgtgagca atgccttgcc agtctcagga agtcacctgg 540 gattggctgc ctcacccact cacagtgcca tccctgcccc aggcctccca gtggcaattc 600 caaacctggg tccctccctg agctctctgc cttctgctct gtctttaatg ctaccaatgg 660 gtattgggga tcgaggggtg atgtgtgggt tacctgaaag aaactacacc ctacctccac 720 caccttaccc tcacctggag agcagttatt tcagaaccat tctacctggc attttatctt 780 atttagctga cagaccacct ccacagtaca tccaccctaa ctctataaat gttgatggta 840 atacagcatt atctatcacc aataaccctt cagcactaga tccctatcag tccaatggaa 900 atgttggatt agaaccaggc attgtttcaa tagactctcg ctctgtgaac acacatggtg 960 cccaaagtct tcatcccagt gatggccatg aggtggcctt ggacacagca atcactatgg 1020 agaacgtttc tagggttacc agcccaattt cgacagatgg aatggcagag gagcttacga 1080 tggacggtgt tgcaggcgag cattcccaaa tcccaaatgg ctccagaagt catgaacctc 1140 tgtctgtgga ttctgtgagc aacaaccttg cagcagacgc tgtaggacat ggtggtgtga 1200 tacccatgca tgggaatggc ctggagctcc ctgtggtcat ggagacagac cacattgcaa 1260 gtcgggtcaa tggcatgtct gacagtgccc tcagtgactc cattcacact gtggccatga 1320 gcaccaactc tgtaagcgtg gcactctcta cctcacacaa ccttgcctcc ctagaatctg 1380 tttccctcca tgaagttggc ctcagcctag aacctgtggc tgtctcctcc atcacccagg 1440 aggttgctat ggggacaggt catgtagatg tatcttcaga cagtctttct tttgtatcac 1500 cttcactgca aatggaagac tccaattcaa acaaggagaa catggcaacc ttgtttacaa 1560 tttggtgtac tctgtgtgac cgcgcctatc cctcggactg tcccgaacat ggaccagtga 1620 cttttgttcc tgacactcca atagagagca gagcaaggct ttctctccca aagcagcttg 1680 ttctccgtca gtcaattgtg ggagcagaag ttggtgtatg gactggagaa accattcctg 1740 tgcggacttg ctttggacct ctaattggcc agcagagtca ctccatggaa gtagcagaat 1800 ggacagacaa ggcagttaac catatctgga agatatacca caatggtgtc ctagaattct 1860 gcatcattac aactgatgaa aatgaatgta attggatgat gtttgtgcgc aaagccagga 1920 accgggaaga gcagaatttg gtggcttatc ctcatgatgg aaaaatcttt ttctgcacct 1980 cacaagatat ccctcctgaa aatgaactgc ttttttatta tagccgagat tatgctcaac 2040 agattggtgt tcctgaacac ccagatgtgc atctctgtaa ctgtggcaag gagtgcaatt 2100 cttacacaga gttcaaagcc catctgacca gccacatcca taaccatctt cctacccagg 2160 gacatagcgg cagccatggg ccaagtcaca gcaaagaaag gaagtggaag tgctcaatgt 2220 gcccccaagc ttttatctct ccttccaaac ttcatgtcca ctttatgggt cacatgggta 2280 tgaagcccca caagtgtgat ttctgtagca aggcttttag tgatcccagc aacctgcgga 2340 cccacctcaa gatacataca ggtcagaaga actacaggtg taccttgtgt gacaagtctt 2400 tcacccagaa ggctcacctg gagtcccaca tggttatcca cactggggag aagaatctta 2460 agtgtgatta ctgtgacaag ttgtttatgc ggaggcagga cctcaagcag cacgtgctca 2520 tccacactca agaacgccag atcaagtgtc ccaagtgtga taagctgttc ttgagaacaa 2580 atcacttaaa gaagcatctc aattctcatg aaggaaaacg ggattatgtc tgtgaaaaat 2640 gtacaaaggc ttatctaacc aaataccatc tcacccgcca cctgaaaacc tgcaaagggc 2700 ccacctccag ttcgtcagca ccagaggagg aagaagagga tgactcagaa gaggaagatc 2760 tagcagactc tgtggggaca gaagactgta ggattaacag tgctgtgtat tcagcggatg 2820 agtctctttc tgcacataaa taaaaggaaa agaaacaagc aattttggat gaaaatgcaa 2880 atggaaaaat acacataacc agttatctac tataatggtt tttatataaa atggttcctg 2940 atttattttc agccagtaat caaaacagac tgggaatgaa taaagcactt acagaagagt 3000 atcctaatga aaacacttta aaacagattg ggaaaactga gcatgtgtcc tgttttaagt 3060 ggtggactgg gagggaagtg tcaacttctg aggtctttat ttacatgata atctgggaga 3120 tgcatttatg cctgaatcaa agctgccttc tgctcaaaca aatcagattt atttcacatt 3180 cttccattat tccattttcc tgctggtcct gtgacttggt aacattctaa acggtccttg 3240 ccccatagcc atcctgattg ctgatagtgt tttatgcaga ctcttgtgac ttatactcac 3300 cacagaatgg attgggacac agcagcataa gtgtgctact tggcagctag taagtttaaa 3360 gcaggacctg ccttaactgc tcctggccac ttggaagttt agggtagatc ttgttttcca 3420 aagtttcggc aggtgcctgg agggcaaata aaaaagcagc agtcagtcag tagtcagtga 3480 tggagagaac aagaggagag atgcctggcc tctgcccaag aaattagctt tgatggaagc 3540 ctgagcaagt cacctggtta ttgtaacgtg gagatctttg taggtttaga catggctccc 3600 tgtctccagt aaacatccag ccattcagac aaagggggcc tggagataca gagagcccaa 3660 ataatgcctg ctggattgtc tcctgatgag tacatgtgga ctcacctgag gaagggaagg 3720 aagggaataa tcttttatgt ttcatttacc ttatgaaaag tgttaaaaca ttgccaactc 3780 aaaataacat tatttaatgc atgtgcaaag ttaggtcttc ccagttgtct cagtgctgag 3840 gaacctcatc agagaagcat ggaagatgcc aaaggatttt tggaaggtaa agaaggctga 3900 atagtgacca catgggcctg ttttcagggt cccagcttag ttaagtcacc catgcacctg 3960 gtcattgtgt ctcccatgca catccagcgt ttctcagaag cagacccacc cttaagttga 4020 caggattgat ggaacatgct ctcctgctca aggcacaacc tctgggctgg agtagaggac 4080 tctggtggga aggttttgct gctaatgtat ttatggaatg aatgtatttc attcaaatct 4140 gtattcctct aggaaggatt aaaattaaac ttttttaaaa tacaggaaaa aaaaaaaaaa 4200 aaaaaaaaaa aaaaaaaaaa aaaaa 4225 <210> 36 <211> 916 <212> DNA <213> Homo sapiens <400> 36 agcgggcgca gagtccggcg gccacggacg cggtaatatt gtccctcggc atccgccgtg 60 gtgagacccg gcgcgttgct gtgaagacgg acgggtctgg aagaagtggg gtgcggtgag 120 ctgagcagac cttttccgct tcgacgtggg gactgcagtg accccggcct gctggcgggg 180 cgggtaacgg gttgagccag gtggggctgc tcagcggcat ggagctgagg tctgaagacc 240 cagcacaggc gattcctttc tgcgacgaga caattgctat ggaaaccaaa gtgctgggtc 300 agcggggatt gaggctccag gatcaagact ggtgtctttc cggaagaccc ttggctaagg 360 cttcccggag cggctgcttc ctgaatgaat ccgccatctc ctgcggggtc ttgacaccga 420 gcaggcgaag aagcctattc caatgccagc tcccccggga aacctacctg gcccacccct 480 ataagtggtg cctcgctctc gttaactctt agactttgtt ccacgtttat aacctaatat 540 ttcggtaacg ccccgcggtt tttgtttact tttcccacac attaatggac cagaaagact 600 tgcttccgga ctttgcttta tgactctgaa caagtcattt ttcccactgg gtctcacttc 660 cctcttgtgt gaaatggcaa ctattaactc tagatgccgg tccggttagg ttgaagatcg 720 aaccagatga gggaagccaa gacttcatag gctggtaagg gggtgaaact ggactggcta 780 acgaagttgc tattttttct cccttccttt tcctcaagct anaagttctt cagattcctt 840 gtgattcttc aggcggcctg ggacccctaa cctccgactt ggatagactc tcttcacatt 900 cattccacag agcctt 916 <210> 37 <211> 521 <212> DNA <213> Homo sapiens <400> 37 tccgtttttt tttttttttt tttttttttt tcagagctct agcacattta ttgggagagt 60 aagcctggga aagactaagg gagtggtggc agggagaaag gctgtgggga atcagagcgg 120 gtgctcagtt gggtcttgaa ggagaagagg aggagggtgg gaggtgggtt gccgaggata 180 tctggttgaa gacttggggg tcaagacaaa gggacttagg gggatggggt ctggttagag 240 ttggggaggg ggcctaggac atccgtgcag agtctgggga ggttggggtg ggagagtctg 300 tacagtttgg tgttgggtgt tctagttggc ctggtgtcca agagttgggg cagtcgaaaa 360 agggttccag agtctggtgt ggctggctgg ggtttcacgg cagaaaatgg gctggagggg 420 gcagttgtag actgtctggt tgcaggggaa ggatcgggtc ttgggaacca ggcctggatg 480 gtctggagtg ggaggtctgt gcagtccagg acgtttgggg g 521 <210> 38 <211> 3161 <212> DNA <213> Homo sapiens <400> 38 gggcgcgagc tcagggcgcc tccggggtcc tcactgcgct ccccacgcgc tgtgacccca 60 tttgttgcac gtgcatgttc aggtcgagag agggatgcga cgtgttcggg gagcagccca 120 ccttgtgggt ggccaatccg ggacgggaat cttaaacttt taactcttgg tgcaaagact 180 tgatccactg gcggctttac gggagcggga aaaaaatggc gctcccgacg ctgccgtcct 240 actggtgcag ccagcagcgc ctgaatcagc agctagcacg acagcgagag caggaggccc 300 ggcttcggca gcagtgggag cagaacagcc gttacttcag gatgtctgac atctgcagct 360 ccaaacaggc agaatggagc tctaaaacct cctaccagcg gagcatgcat gcctatcagc 420 gggagaagat gaaggaggag aagaggagga gtctggaggc ccgacgggaa aagctcaggc 480 agctcatgca ggaggagcag gacctgctgg ccagagaact ggaggagctg aggctgagca 540 tgaacttgca ggaaagaaga atccgggagc agcacgggaa gctgaaatca gccaaagaag 600 agcagaggaa actgattgct gaacaacttt tgtacgaaca ctggaaaaag aacaacccga 660 aacttcgaga gatggagctg gaccttcacc agaagcatgt cgtaaactct tgggaaatgc 720 agaaagaaga aaaaaaacag caagaagcca ccgcagagca agagaacaaa cggtatgaaa 780 atgaatatga aagggcccga agggaggcgc tagaaaggat gaaagctgaa gaggagagga 840 ggcagctgga ggacaagctc caggccgagg cactgctgca acagatggag gagctgaagc 900 tgaaggaggt ggaggcgacc aaactaaaga aggagcagga gaatctgttg aagcagcggt 960 gggagctaga gaggctggag gaagagcgaa agcagatgga agccttccgg cagaaggcag 1020 agctggggcg tttcttgaga catcagtata acgctcaact cagcagacgc acacagcaga 1080 tccaagagga gctggaggca gacaggcgga tcctgcaggc cctcctcgag aaggaggacg 1140 agagccagcg cctccacctg gccaggcggg agcaggtcat ggccgatgtg gcctggatga 1200 agcaggccat tgaggagcag ctgcagctgg agcgggcgcg ggaggcagag ctgcagatgc 1260 tgctgaggga ggaggccaag gagatgtggg aaaagagaga ggcagagtgg gcccgagagc 1320 gcagcgcacg ggacagactg atgagcgagg ttctgacagg gagacaacag caaatacaag 1380 agaagattga gcagaaccga cgggcacaag aggaatccct gaaacacagg gagcaactta 1440 ttcgaaatct tgaggaggtg agagagttgg ctcgtcgcga gaaagaggag agtgaaaagc 1500 tgaaatcggc caggaagcag gagctggaag cccaggttgc agagcgccgg ctgcaggcat 1560 gggaagcaga ccagcaggag gaggaggaag aggaggaggc ccggcgggtc gagcagctct 1620 cagatgccct gctgcagcag gaggcggaga ctatggctga gcagggctac cggcctaagc 1680 cttacggaca tccaaaaatt gcttggaact gacttcatgg gtaccataag tacagagaac 1740 aagggatgct gaggcttctg atcccagccg ccaggcagtt ttacagggct ctgttaacag 1800 taagtgcccg gggcactgtc agatggctca gcagtgcctg ctcaggttca tcattgaaac 1860 atcccagtgt ttggccagac attaaggtgt cgtgagagtc cctttcatgc ctttcttacc 1920 caagcaaggg tctttgatgg gcacgtgttt acagcgctgc tgcatagtct tgtaatatat 1980 taacagtcac atcaactgaa ggtcaatact aagagccaca ggttgtacct gtgatggggc 2040 gtgtggtttc ctgttgtctc acctttaatt gtcaacctcc agtgttgact ctagaaatat 2100 gaggaaagct tttcagtttt taaaattgcc atttaaattt agtctattaa aaacaaacct 2160 agaggtcttg gtgcagttga tttcagagtt tattaattta gtggtcccaa aagtattaca 2220 tcttttatat tctggaagaa aagaactgtg aacaaattag aaccccggaa cactctgacg 2280 tccatggacg cattccagaa aagtggcaag agatgagtct ttcctcctcc aggaagcatt 2340 ttggtagaat ttccatagag cattgtctgt gagtgactga tcccaacatg tatgttacta 2400 agccccaaaa cgaacttcaa actgggtgtg gtggcacgtg cctttagtcc cagctacccg 2460 ggaggctgcg gcaagaggat tgcttgagcc caggagttcg agtccaacct gggcaaaaga 2520 gtgagacccc atctctaaaa ccaaaaaggt accttagaag gtcacctggt tggctaacct 2580 tttaaaggca ggggcgtgac acgtaggaca cattgggaat gtcttggcta ctacatgtag 2640 ccttctggga tatatgtgcc cagagggaga agcactgagc ctgaagaaac tagatgagtc 2700 tcagaaccac agaccggcca gaaatctctc ccaccattat atcagcgtga tacaggtcta 2760 cattcatttc tacaaacagg aacaagttcc ttgcagcaat aatattattt tatgacttgt 2820 atttttacta tacccttcct ctgaggttta gttttcatca cattatgttc aagattccat 2880 atctccgtaa attacagcta attacagggc attgttccat ggttattaaa aatcagagtt 2940 tattaaaaat cctgagtctt aagggctgtc ttacctttca cttccactgt cctgtagaaa 3000 cagatcaagc tgcaaaccac gtccttcatc tgttgttcat tttcttgcaa ctctttgact 3060 ctgatcccct gagcagcacg ttcatcacgc atgctctctg ttgcgttccc catttcagat 3120 gtccagtaat ggtgaaataa aatcctgctt cggaaaaaaa a 3161 <210> 39 <211> 4489 <212> DNA <213> Homo sapiens <400> 39 tggcgataca ttcacacagg aacagctatg ccatgtttac gaattccggt tttgaaaaaa 60 ctttcgttga cagttacaca aagggtcact tcctccccag cgacacatgg gcctctcaaa 120 ggagaggagg gagtaagtcc cacggtaggg ccagtggttg ctccctgggt tttggaatca 180 tttctgcgga gctttcaagg ccagaccctg ggcttagggt cgagacttta tagcagtgac 240 agccagaccc agcaagatgg ctgcgaccgt gaaaccctgg gcggcgatcc gggtgcgcat 300 catgagctga gagcgctggc tgttgccccg gtggaaggag tagaggccgt aggtgagggc 360 ggccgccgtg gccaggcaac ctatgggtac caccgggttc tcgcgggcaa gtcaagctgg 420 gaggaccaag gccgggcagc cgggagcacc caaggcagga aaatgaggtg gctgcttctc 480 tattatgctc tgtgcttctc cctgtcaaag gcttcagccc acaccgtgga gctaaacaat 540 atgtttggcc agatccagtc gcctggttat ccagactcct atcccagtga ttcagaggtg 600 acttggaata tcactgtccc agatgggttt cggatcaagc tttacttcat gcacttcaac 660 ttggaatcct cctacctttg tgaatatgac tatgtgaagg tagaaactga ggaccaggtg 720 ctggcaacct tctgtggcag ggagaccaca gacacagagc agactcccgg ccaggaggtg 780 gtcctctccc ctggctcctt catgtccatc actttccggt cagatttctc caatgaggag 840 cgtttcacag gctttgatgc ccactacatg gctgtggatg tggacgagtg caaggagagg 900 gaggacgagg agctgtcctg tgaccactac tgccacaact acattggcgg ctactactgc 960 tcctgccgct tcggctacat cctccacaca gacaacagga cctgccgagt ggagtgcagt 1020 gacaacctct tcactcaaag gactggggtg atcaccagcc ctgacttccc aaacccttac 1080 cccaagagct ctgaatgcct gtataccatc gagctggagg agggtttcat ggtcaacctg 1140 cagtttgagg acatatttga cattgaggac catcctgagg tgccctgccc ctatgactac 1200 atcaagatca aagttggtcc aaaagttttg gggcctttct gtggagagaa agccccagaa 1260 cccatcagca cccagagcca cagtgtcctg atcctgttcc atagtgacaa ctcgggagag 1320 aaccggggct ggaggctctc atacagggct gcaggaaatg agtgcccaga gctacagcct 1380 cctgtccatg ggaaaatcga gccctcccaa gccaagtatt tcttcaaaga ccaagtgctc 1440 gtcagctgtg acacaggcta caaagtgctg aaggataatg tggagatgga cacattccag 1500 attgagtgtc tgaaggatgg gacgtggagt aacaagattc ccacctgtaa aattgtagac 1560 tgtagagccc caggagagct ggaacacggg ctgatcacct tctctacaag gaacaacctc 1620 accacataca agtctgagat caaatactcc tgtcaggagc cctattacaa gatgctcaac 1680 aataacacag gtatatatac ctgttctgcc caaggagtct ggatgaataa agtattgggg 1740 agaagcctac ccacctgcct tccagtgtgt gggctcccca agttctcccg gaagctgatg 1800 gccaggatct tcaatggacg cccagcccag aaaggcacca ctccctggat tgccatgctg 1860 tcacacctga atgggcagcc cttctgcgga ggctcccttc taggctccag ctggatcgtg 1920 accgccgcac actgcctcca ccagtcactc gatccgaaag atccgaccct acgtgattca 1980 gacttgctca gcccttctga cttcaaaatc atcctgggca agcattggag gctccggtca 2040 gatgaaaatg aacagcatct cggcgtaaaa cacaccactc tccaccccaa gtatgatccc 2100 aacacattcg agaatgacgt ggctctggtg gagctgttgg agagcccagt gctgaatgcc 2160 ttcgtgatgc ccatctgtct gcctgaggga ccccagcagg aaggagccat ggtcatcgtc 2220 agcggctggg gaaagcagtt cttgcaaagg ttcccagaga ccctgatgga gattgaaatc 2280 ccgattgttg accacagcac ctgccagaag gcttatgccc cgctgaagaa gaaagtgacc 2340 agggacatga tctgtgctgg ggagaaggaa gggggaaagg acgcctgttc gggtgactct 2400 ggaggcccca tggtgaccct gaatagagaa agaggccagt ggtacctggt gggcactgtg 2460 tcctggggtg atgactgtgg gaagaaggac cgctacggag tatactctta catccaccac 2520 aacaaggact ggatccagag ggtcaccgga gtgaggaact gaatttggct cctcagcccc 2580 agcaccacca gctgtgggca gtcagtagca gaggacgatc ctccgatgaa agcagccatt 2640 tctcctttcc ttcctcccat cccccctcct tcggcctatc cattactggg caatagagca 2700 ggtatcttca cccccttttc actctcttta aagagatgga gcaagagagt ggtcagaaca 2760 caggccgaat ccaggctcta tcacttacta gttttcagtt ctgggcaggt gacttcatct 2820 cttcgaactt cagtttcttc ataagatgga aatgctatac cttacctacc tcgtaaaagt 2880 ctgatgagga aaagattaac taatagatgc atagcactta acagagtgca tagcatacac 2940 tgttttcaat aaatgcacct tagcagaagg tcgatgtgtc taccaggcag acgaagctct 3000 cttacaaacc cctgcctggg tcttagcatt gatcagtgac acacctctcc cctcaacctt 3060 gaccatctcc atctgccctt aaatgctgta tgcttttttg ccaccgtgca acttgcccaa 3120 catcaatctt caccctcatc cctaaaaaag taaaacagac aaggttctga gtcctgtggt 3180 atgtccccta gcaaatgtag ctaggaacat gcactagatg ccagattgcg ggagggcctg 3240 agagaagcag ggacaggagg gagcctgggg attgtggttt gggaaggcag acacctggtt 3300 ctagaactag ctctgccctt agccccctgt atgaccctat gcaagtcctc ctccctcatc 3360 tcaaagggtc ctccaagctc tgacgatcta agatacaata aagccatttt ccccctgata 3420 agatgaggta aagccaatgt aaccaaaagg caaaaattac aatcggttca aaggaacttt 3480 gatgcagaca aaatgctgct gctgctgctc ctgaaatacc cacccctttc cactacgggt 3540 gggttcccaa gaacatggaa caggcaaagt gtgagccaaa ggatccttcc ttattcctaa 3600 gcagagcatc tgctctgggc cctggcctcc ttcccttctt gggaaactgg gctgcatgaa 3660 ggtgggccct ggtagtttgt accccaaggc ccctatactc ttccttccta tgtccacagc 3720 tgaccccaag cagccgttcc ccgactcctc acccctgagc ctcaccctga actccctcat 3780 cttgcaaggc cataagtgtt ttccaagcaa aatgcctctc ccatcctctc tcaggaagct 3840 tctagagact ttatgccctc cagagctcca agatataagc cctccaaggg atcagaagct 3900 ccaagttcct gtcttctgtt ttatagaaat tgatcttccc tgggggactt taactcttga 3960 cctgtatgca gctgttggag taattccagg tctcttgaaa aaaaagagga agataatgga 4020 gaatgagaac atatatatat atatattaag ccccaggctg aatacccagg gacagcaatt 4080 cacagcctgc ctctggttct ataaacaagt cattctacct ctttgtgccc tgctgtttat 4140 tctgtaaggg gaaggtggca atgggaccca gctccatcag acacttgtca agctagcaga 4200 aactccattt tcaatgccaa agaagaactg taatgctgtt ttggaatcat cccaaggcat 4260 cccaaaacac catatcttcc catttcaagc actgcctggg cacaccccaa catcccaggc 4320 tgtggtggct cctgtgggaa ctacctagat gaagagagta tcatttatac cttctaggag 4380 ctcctattgg gagacatgaa acatatgtaa ttgactacca tgtaatagaa caaaccctgc 4440 caagtgctgc tttggaaagt catggaggta aaagaaagac ccgaaattc 4489 <210> 40 <211> 1443 <212> DNA <213> Homo sapiens <400> 40 catggccgcc ccgccgcgcc ccgcgccatc gccccccgcc ccgcggcgcc tcgacacgag 60 cgacgtcctg cagcagatca tggccatcac cgaccagagc ctggacgagg cacaggccag 120 aaagcatgct ctgaattgcc atcggatgaa gcctgctctg ttcagcgtgc tctgtgagat 180 caaggaaaag acagtggtaa gcatccgtgg cattcaagac gaagatcccc ctgacgccca 240 gctcctgagg ctggataaca tgctgctggc tgagggcgtg tgcaggcccg agaagagagg 300 aagaggagga gcggtggcca gggccggcac agcaacacca ggtggctgtc caaatgacaa 360 tagcattgag cactctgact acagggccaa gctgtcccag atccgacaga tttaccactc 420 tgagctagag aaatatgaac aggcctgtcg tgagttcacc acgcacgtca ccaacctcct 480 ccaggagcag agcaggatga ggcctgtctc ccctaaggag attgagcgca tggtcggcgc 540 cattcacggc aagttcagcg ccatccagat gcagttgaag cagagcacct gtgaggcagt 600 gatgaccctg cgttcgcggc tgctcgatgc caggcgcaag cggcggaatt tcagcaagca 660 ggcgacggaa gtgctgaatg agtattttta ctcccatctg aacaaccctt accccagcga 720 agaagccaaa gaagagctgg ccaggaaggg cggcctcacc atctcccagg tctctaactg 780 gtttggcaac aaaagaatcc ggtataaaaa gaacatgggg aagtttcaag aagaggctac 840 catttacacg ggtaaaacgg ctgtggatac cacggaagtt ggggtcccag ggaaccacgc 900 cagctgcctg tcaacaccta gctccggctc ctctggaccc ttcccgctgc ccagcgctgg 960 ggacgccttc ctcaccctgc ggactctggc ctctctccag cctcctcctg ggggaggctg 1020 cctgcagtcc caggcccagg gtagctggca gggggccacc ccccaacctg caactgcctc 1080 acctgctgga gaccctggca gcatcaactc cagtacatct aattaagttt gggggataag 1140 caggaaagag cgctgcgtga gctgccatgt atcgccagcc gttgctttgt tactgaacgt 1200 gccgccgacg acctcagaaa acccagatgg gtggtggtgc ccatgagccc ctgctcctca 1260 gccaggcccg tggcgccggc tcatgtgtct gctgcgactc gagatggcct gaaacgccac 1320 tcattctccc acttcagttc gtttttttga cagtaatttt atggtaacgc tatgaattga 1380 attgtctgtt ctaggactgg gcacagattt tcccattaaa atttttgact tattttaaaa 1440 aaa 1443 <210> 41 <211> 3109 <212> DNA <213> Homo sapiens <400> 41 tcgggcagtg gaggctccgc gggtcgaaag cggctccatg cccatcggtg ggtggaacgt 60 gtagaggtcg gaacgccgag gtcgagtctg gtggcgcctc ggtatcctta acgtggtctc 120 tgtttaacgt atttcattta gcccccgttg ggattgattc attgggagca gtttcgctgg 180 tctggatcct ccaggagctg gacaaccttg acgggctttt tgtcttgggt tccagccccc 240 tttcccttcc tcctcctcca gatgcctttt ctctgccctc ctcgcccggt acagacattt 300 ccagcgcagg ctgctgctcg tggtgtccgt cgtcgaagcc acttcttggg atttcggctc 360 gtttcactct ggggtgtttt ttgaggaggg agagtgcccc cctcctccac gatgggattt 420 ttctcccttg ccgaaatgga ctttcattga tttctactta cttccacgtt tagtgaccaa 480 ttccctaggc gtatttttgt ggtagttcct tttttcaaat acatactctg taaaatggag 540 aacgaaattt ttactcccct tctggagcag ttcatgacca gccctttggt cacttgggtt 600 aaaacgtttg gacctctggc cgcaggaaat gggaccaacc ttgatgaata tgtggctttg 660 gtggatgggg tattcttgaa ccaggtcatg ctccaaatta atcctaaatt ggagagtcag 720 agagtaaata aaaagtcaat aatgatgcct cacttagaat gcacaatcta tccattttgg 780 tgagacagat aaaattttat taccaggaga ctttgcagca attgatcatg atgtcgttgc 840 caaatgtctt aatcattggc aaaaatccct tttctgaaca aggcacagaa gaagttaaaa 900 aactgctttt acttttattg ggttgtgcag ttcagtgtca gaaaaaagag gaatttattg 960 aaagaattca aggtttagat tttgatacaa aagcagcggt tgccgcacat attcaagagg 1020 taactcataa tcaggaaaat gtgtttgacc tgcaatggat ggaagtgact gatatgtcgc 1080 aggaggacat agaaccactc ttgaaaaata tggcattgca tctaaaaaga cttatagatg 1140 agagagatga acattcagag actatcatag aactctctga agagcgggat ggtctccatt 1200 ttctacccca tgcctcttca tctgcacagt caccctgtgg ttctccaggc atgaagcgaa 1260 cagaaagtcg acaacatctg tcggtggaac tggcagatgc taaagccaag ataagaaggc 1320 ttaggcagga attggaggaa aagactgagc agttgttgga ttgtaaacaa gaacttgagc 1380 aaatggaaat agaactcaaa aggctgcaac aagagaacat gaatttgctt tcggatgctc 1440 gctctgccag aatgtaccga gatgaattag atgcacttcg agagaaagca gtcagagtcg 1500 ataagcttga aagtgaagtc agcagatata aagagagact acatgatatt gaattttata 1560 aggcaagagt tgaggaatta aaagaagaca atcaagtttt attagaaaca aaaaccatgt 1620 tggaagacca actagaggga actcgtgctc gttctgataa attacatgaa ttagaaaaag 1680 agaacttaca actgaaagct aaacttcatg atatggaaat ggaacgagat atggatagaa 1740 aaaagattga agaattaatg gaagaaaata tgactttgga aatggcacag aaacaaagta 1800 tggatgaatc attacatctt ggctgggaac tggaacagat atccagaact agtgaacttt 1860 ccgaagcacc ccagaaatcc ctgggccatg aggtgaatga gttgacatca agtagattat 1920 tgaagctaga gatggaaaat caaagtttga caaaaaccgt agaagagctt cggactactg 1980 tggattctgt agaaggcaat gcttccaaaa tcctgaaaat ggaaaaagaa aatcaaaggc 2040 tcagtaaaaa ggttgagatt cttgaaaatg agattgttca agaaaagcaa agtcttcaga 2100 attgtcagaa tttaagcaag gatctaatga aggagaaagc tcagcttgaa aaaacaatag 2160 aaacactgag agaaaattca gagagacaga ttaagatact ggaacaggaa aatgaacatc 2220 tgaatcaaac agtgtcttcc ttaaggcagc ggtcccagat aagtgcagaa gcaagagtga 2280 aagacattga aaaagaaaac aaaattcttc atgaatctat caaagaaaca agtagcaagc 2340 taagcaagat tgaatttgaa aaaagacaaa ttaaaaaaga attggaacat tataaagaaa 2400 aaggagaacg agctgaagaa cttgaaaatg aattgcatca tcttgaaaaa gaaaatgaat 2460 tattacagaa aaaaataact aatttaaaaa ttacttgtga aaaaattgag gccttagaac 2520 aagaaaattc agagctagaa agagaaaata gaaaattaaa aaaaacattg gatagcttta 2580 aaaatctgac ctttcagtta gaatccctag aaaaagagaa ttcccaactt gatgaggaaa 2640 acttagaact gcgaaggaat gtagaatctt tgaagtgtgc aagcatgaaa atggctcagc 2700 tacagctaga aaacaaagaa ctggaaagtg aaaaagagca acttaagaag ggtttggagc 2760 tcctgaaagc atctttcaag aaaacagaac gcttagaagt tagctaccag ggtttagata 2820 tagaaaatca aagactgcaa aaaactttag agaacagcaa taaaaaaatc cagcaattag 2880 agagtgaact acaagactta gagatggaaa atcaaacatt gcagaaaaac ctagaagaac 2940 taaaaatatc tagcaaaaga ctagaacagc tgggaaaaag aaaataaatc catttagagc 3000 cagagacttc ctccaactgg gaaaagggat aaggaaccaa ttgggaggag ggaaattaag 3060 aggctcccgg ccaaccaagc caggaattta agattccaca ttagggagg 3109 <210> 42 <211> 833 <212> DNA <213> Homo sapiens <400> 42 aaaggatgta cagaggatcc ccaaccgcct gcgaaaccca agccgccgcg taggagcgtg 60 cgttcgggcc ctcttctccc acctgttcga ctccccatcc ccaggatgtc aacctcagtc 120 cctcaaggcc atacctggac ccaacgggtg aagaaagacg atgaggagga ggacccgctg 180 gaccagctga tctcccgctc tggctgtgct gcctcccact ttgcagtgca ggagtgcatg 240 gcccagcacc aggactggcg gcaatgccag ccacaggtgc aggcgttcaa ggattgcatg 300 agtgaacagc aggcgaggcg gcaagaggag ctgcagagga ggcaagaaca agccggtgcc 360 caccactgag accccaaacc acctatcccc agtagatggc cctgccaaga ccagcaccca 420 gcaagattat agaggaagaa atcctaaatg ctggtgtggg aggtctaaaa catggggaga 480 gtttttggat ctggagttga gagccatggg tttggacatg actggcacaa acagctgtca 540 tatgttcatg gtcagatgtc atacattctc agctgtcttg ttccaccagt atttaccagg 600 aaaacaaaga atgtgttaag ggatgctccc ccaccccaca tcttaagtca gtgtgccaag 660 tactgagatg attttaggga cattttattt taaattaaat ttacaatcta atggtaaatt 720 gattacctaa ttagtgcctt tctctttcat cacttgttct ggatgtttca atcagtttag 780 tggaaggaaa aataaatggg gaaacttttt attcaaaaaa aaaaaaaaaa aaa 833 <210> 43 <211> 2985 <212> DNA <213> Homo sapiens <400> 43 atggggggcg gagccgaggc ctccgaagcg gaagtgggtt gctgttgagg cggcggcatc 60 tttctcgagg agctctcctg ggcggctgaa gaaggagctt cttctccgga gtgcgccggc 120 ggtggcgcct gcggacctaa ctagctccag gttaggccga gctttgcggg aaagcagcgg 180 acttgaaaat actggaaatc tgtccggatc caaattattt tgcaagccag atgagtaacc 240 agagggcatg aaaggttgag aacatttgac ttccctgcaa accttggtat agatcacttc 300 cttttctgta ggaaaggaaa ggcaccaaag agcacaatga gtacaagaaa gcgtcgtggt 360 ggagcaataa attctagaca agctcagaag cgaactcggg aagcaacctc cacccccgag 420 atctccttgg aagcagaacc catagaactc gtggaaactg ctggagatga aattgtggac 480 ctcacttgtg aatctttaga gcctgtggtg gttgatctga ctcacaatga ctctgttgtg 540 attgttgacg aaagaagaag accaaggagg aatgctagga ggctgcccca ggaccatgct 600 gacagctgtg tggtgagcag tgacgatgag gagttgtcca gggacagaga cgtatatgtg 660 actacccata ctcccagaaa cgccagggat gagggcgcta caggcctcag gccctcaggt 720 actgtcagtt gtcccatctg catggacgga tactcagaga tcgtgcagaa tggacgtctc 780 atcgtttcca cagaatgcgg ccatgtcttc tgtagccagt gcctccgtga ttccctgaag 840 aatgctaata cttgcccaac ttgtaggaaa aagatcaacc acaaacggta ccaccccatt 900 tatatatgaa gtattcagag ccccccagga gagacggatg gacagacaga cagccaggtt 960 ctccagtggt atctgcctcc attttcctga gatcaaaaag actgtttcga aaccaacatc 1020 tgatatgtaa actgctcttt tgtttccaac cccttccttt tgttatctcc agtttgatgc 1080 tatggcgctg gacccagggc cctcccaggc catctctgtt cctctggggt ggtccagttc 1140 tagagtggga gaaagggagt caggcgcatt gggaatcgtg gttccagtct ggttgcagaa 1200 tctgcacatt tgccaagaaa ttttccctgt ttggaaagtt tgccccagct ttcccgggca 1260 caccaccttt tgtcccaagt gtctgccggt cgaccaatct gcctgccaca cattgaccaa 1320 gccagacccg gttcacccag ctcgaggatc ccaggttgaa gagtggcccc ttgaggccct 1380 ggaaagacca atcactggac ttcttccctt gagagtcaga ggtcacccgt gattctgcct 1440 gcaccttatc attgatctgc agtgatttct gcaaatcaag agaaactctg cagggcactc 1500 ccctgtttcc taagaacgaa aaagtgcaat aaaggccatt cgttacctac ttttcagcag 1560 cccacaagat gtagcactat tagtgtcccc ctcagaggct taatgttgcc tgtggagcag 1620 tgcccatccc agcccgtttc tgcccaccag ttgttctcag gaaccttacc catgctccag 1680 cgtccttcac ctggcacagg acatgcaaga taaatagggc aggcacgtgt ttgggtgtcc 1740 tctcttttct gataaaatcc atcccgtgtt tgccacacgc cctccagtcc tcagttccca 1800 ctgcctaacg tctgcccccg tgtagatact gagaggtggt ggcagtaatt gtggccttat 1860 cagccgctca gttccaggct tttgcccagg tcactgttgc cccatgttcg gagaacctgg 1920 cccacctgtc ttggctttct catccttccc aacccagtgc cgtttatttc agaagcttcc 1980 tggccactgg gcttggatgc ttcgggcttc tgactgctcc ataggttttg actggtgaaa 2040 caggggccca gatgacaacc tctccttcgc tccacaggta cgcgggagcc tcaggttctc 2100 tcaggggcag caaagtggcc caagctgccc ctgacagcac agggcctggg gggtggctaa 2160 cgagagaggc cttacagtgc cggcatgcct cctcttccac tgtcgtcctt cctcagaggg 2220 cctcacgcca aacaaacggc cttttcgtgt gaaacatctt cagggcggga aaggggccac 2280 ttctggcttt gttagcaata actgaccttc agtttaccct tctgaaggag cagggactca 2340 gcacagaatt cactttagac ggggctgaag gagtgtccct cctctatgtg aaaagaaaat 2400 tgttttattc ttcattctga ctttttaact gtttggctca cttccagtta gtttgaatga 2460 aaataataat tttctacttg gagttgaaga gggcagaatc cgcagctctc atcattgtga 2520 tgtgtagcat gtctgccctc tgactggaca tcattgccat taactttctt ctgggcatca 2580 cggcaatgtc acgatgccca gacttggagc aaggcaacct tggagtcagt ccactcataa 2640 aatatggtaa cacccatttt aaaatttaag ttttgtcctt aaagacaact tcagtggtta 2700 attataaaag ttgtgttact tcgtcctaaa ttaaattgat agaaagattt aaaaatgtgt 2760 tttgtttcta ctattcagaa actgcgaact agggaaaggt tggtatgaag aaatgtcttt 2820 ccttttttca atgtacatag ttcaactctt tctttgttac atttaaacta tatccatgga 2880 tatcagtctg ctttggactc ctctgctagt gttacagatg gaaataaaac cattaatttg 2940 aaccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 2985 <210> 44 <211> 7332 <212> DNA <213> Homo sapiens <400> 44 ttcagacaaa tttaatcaca atgaccacat ataatgtgct gtttgagatt cttatagaac 60 agattggtac tcaggtgata cataaacagc atccagatcc tgattcttca gtgaagatac 120 aaaaccctca gatactaaaa gtaattgcga ccctacttcg aaattctccc cagtgcccag 180 agagcatgga ggttcgcaga gcctttcttt ctgacatgat taaacttttt aataacagta 240 gagaaaacag gaggagcttg ctacaatgct ctgtgtggca agaatggatg ctttctctct 300 gctattttaa tcctaagaat tcagatgagc aaaagataac agaaatggta tacgccatat 360 tcagaatcct gctttaccat gcagtcaaat atgagtgggg tggctggcgt gtatgggtag 420 acactttatc aatcactcat tcaaaggtca cttttgaaat acacaaagaa aaccttgcca 480 atatatttag ggaacagcaa ggaaaagttg atgaagaaat agggctgtgt tcttcaactt 540 cagttcaagc agcctctggc attagaaggg atattaatgt ttcagtagga tcccagcaac 600 cagatacgaa ggattctcct gtctgtcctc atttcaccac aaatggtaat gaaaattcaa 660 gtatagagaa gacaagttca ctagaatctg catctaatat tgaactgcaa actactaata 720 catcttatga agaaatgaaa gctgagcaag aaaatcagga gttaccagat gaaggcactt 780 tggaagaaac actgacaaat gagacaagga atgcagatga tttagaagta tcttctgaca 840 taatagaagc tgtggctatt tcctctaatt cttttataac aactggcaaa gattcaatga 900 ctgtcagtga agtaactgct tctataagtt ctccttcaga agaggatgcc tcagagatgc 960 cagaattctt ggataaatct atagtagagg aagaggaaga tgatgattat gtggaactga 1020 aagtagaagg cagtcctact gaggaagcta atctacccac agagctccaa gataacagtt 1080 tgtctccagc tgcatctgaa gccggtgaaa aactggacat gtttggtaat gatgacaaat 1140 taatatttca agaaggaaaa cctgttactg aaaagcaaac tgatactgaa actcaagatt 1200 ctaaagattc tggaattcag actatgacag catcagggtc ttcagctatg tcaccagaaa 1260 ctactgtttc ccaaatagct gtagaatcag accttggtca gatgctggag gaagggaaga 1320 aagcaactaa cctcactaga gaaaccaaat taattaatga ttgtcatggt agtgtctctg 1380 aggcttcttc tgagcaaaag attgcgaagt tggatgtttc caatgttgct acagatactg 1440 agaggctgga gttgaaggcc agtcccaacg tggaagcacc tcaacctcat cgacatgtgc 1500 ttgagatatc aaggcaacat gagcagccag ggcaaggaat agcaccagat gcagttaatg 1560 gacaaaggag ggattccaga tctactgtgt ttcgtattcc tgagttcaac tggtctcaga 1620 tgcatcaacg tttgctcact gatctattat tttcaataga aacagatata cagatgtgga 1680 gaagccattc aacaaagaca gttatggact tcgtgaatag cagtgataat gtcatctttg 1740 tacacaacac aattcatctc atctctcaag tgatggacaa tatggtcatg gcttgtgggg 1800 gtatactgcc attgctttca gctgctacat cggctacaca tgaactggaa aatattgaac 1860 ctactcaagg cctttcaata gaagcctctg tgacattttt gcagaggcta attagccttg 1920 tggatgtgct tatatttgca agttctcttg gctttactga aattgaagct gaaaaaagta 1980 tgtcatctgg aggaattttg cggcagtgtc tccgactagt ttgtgcagtc gcagtaagga 2040 attgcttgga gtgtcaacag cattcacaac tgaaaactag gggagataaa gccttgaaac 2100 caatgcatag ccttattcct ttagggaaat ctgcagcgaa gagcccagtg gacattgtga 2160 ctggcggtat atctccagta agagatcttg acaggcttct acaggacatg gatattaatc 2220 ggcttagggc agttgttttc agagacatag aggatagcaa acaagctcaa tttttagcct 2280 tggcagtagt atactttatc tctgttctta tggtctccaa gtacagagac attttggaac 2340 cccaaaatga aaggcatagc cagtcatgta cagaaactgg cagtgaaaat gagaatgtat 2400 cactctctga aatcacacca gcagcattca gcactttaac tacggcatca gtggaagaat 2460 ctgaaagcac atcatctgct cgaaggaggg actcaggcat tggggaagaa acagccactg 2520 gtttaggaag ccatgtggaa gtaactcctc acacagcacc tcctggtgtc agtgcaggcc 2580 cagatgcaat cagcgaggtg ctatctactc tttctttaga agtcaataag tctccggaaa 2640 ccaaaaatga tagaggaaat gacttggaca ctaaggctac accgtcagtt tcagtttcaa 2700 aaaacgtcaa tgtgaaagac attctccgaa gcttggttaa cataccagca gatggagtca 2760 cagtggatcc tgcccttctg ccaccagcct gccttggagc ccttggtgat ctatctgtgg 2820 aacaacccgt gcagttcaga tcttttgaca gaagtgtcat tgttgcagca aaaaagtcag 2880 cagtctcacc ttccaccttt aatacaagca tacctaccaa tgctgtcagt gtggtttcct 2940 cagtagattc agcccaagcc tcagatatgg gaggagaatc accaggcagt agatcatcta 3000 atgcaaaatt gccctcagtt ccaacagttg attcagtttc acaagatccg gtttcaaata 3060 tgagtattac agagaggctt gaacacgctt tggaaaaggc agctcctctc cttcgtgaga 3120 tttttgtgga ttttgcacct tttctttctc ggacactttt gggtagccat ggacaagaac 3180 tgcttataga aggaacaagt ctggtttgca tgaagtcgag tagttcagtt gtggaattgg 3240 ttatgctact gtgttctcag gagtggcaaa attctattca gaagaatgca ggccttgctt 3300 ttatcgaact tgtcaatgaa ggaaggttgc ttagccagac aatgaaggat catctagtaa 3360 gagtagcaaa tgaagctgaa tttatcctga gcaggcagag agcagaagat attcacagac 3420 atgcggaatt tgagtcactg tgtgcccagt attctgcaga caaacgagaa gatgagaaga 3480 tgtgtgatca tttgataaga gcagcaaaat atcgtgacca cgtgacagca actcaactaa 3540 tccagaaaat tatcaacatt ctcacagaca agcatggagc ctggggaaat tctgcagtga 3600 gtcgtcctct tgagttctgg cgccttgact actgggaaga tgacttgcgg cgccggcgac 3660 gatttgtgcg taaccctcta ggatcgacac atcctgaagc gacactaaaa acagccgtgg 3720 aacatgtgtg catttttaaa ttgagagaga acagcaaagc cacagatgaa gatatccttg 3780 ctaaaggaaa acagtccatc aggagtcagg ctttaggaaa tcagaactca gaaaacgaga 3840 tcctcctgga aggcgatgat gatactctgt catccgtgga tgagaaagat ttagagaatc 3900 ttgccggtcc tgttagcctg agcacaccag ctcagcttgt ggccccctct gttgtagtaa 3960 agggcactct ttctgtcacc tcctccgaac tctattttga ggtggatgaa gaggatccta 4020 acttcaaaaa aatcgacccc aagatcttgg catatacaga agggctgcat ggaaaatggc 4080 tgttcacaga gatacgatca atcttttctc gtcgttatct tttgcaaaat acagccctgg 4140 agatctttat ggcaaacaga gttgctgtga tgttcaactt cccagaccct gcaacagtaa 4200 agaaagtggt taactttcta cctcgtgttg gcgttggaac aagttttgga ttgcctcaaa 4260 ccagacgtat ttcattagct agtccacgtc agctttttaa ggcttctaat atgacccagc 4320 gatggcaaca cagagagata tctaattttg agtacttgat gtttctcaac acgatagcag 4380 gacggagtta taatgactta aatcagtatc cagtgtttcc ttgggtcatc actaattatg 4440 aatcagaaga actggatctt accttgccca ccaacttcag agatttgtcc aagccaatag 4500 gagctctgaa cccaaaaaga gcagcattct tcgctgagcg ttatgaatca tgggaagatg 4560 atcaagttcc aaagtttcac tatggtactc attactcaac tgcaagtttt gttcttgcat 4620 ggctgctaag aatagaaccc tttacaactt atttcctaaa tttgcaagga ggcaaatttg 4680 atcatgcaga tcgaactttt tcatcaattt ccagagcttg gcgaaacagt cagcgtgata 4740 cctctgatat taaggagttg atccctgaat tttattatct ccctgagatg tttgtcaact 4800 tcaataatta taatcttgga gtgatggatg atgggacagt agtgtctgat gtcgaacttc 4860 ctccttgggc caaaacctca gaagaatttg ttcacataaa cagattggcc ctggagagtg 4920 aatttgtttc ctgccagctt caccaatgga ttgatctcat ttttggctat aaacagcaag 4980 gaccagaagc tgtccgagcc ctcaatgtgt tctattactt gacctatgaa ggagctgtca 5040 atctgaattc aataactgat cctgtgttga gagaggctgt tgaagctcaa atccgaagtt 5100 ttggacagac tccttctcaa ctactcatag agccccatcc tcccagaggt tctgccatgc 5160 aagtgagtcc attgatgttc acagacaaag cccagcagga tgttatcatg gtcctcaagt 5220 ttccctccaa ctcccctgtt actcacgtgg cagccaacac ccagcctggt ttggcaactc 5280 ccgctgtgat cacagtcact gctaacaggt tatttgcggt gaacaaatgg cacaaccttc 5340 ctgctcatca aggtgctgta caagaccagc cataccagct gccagtggaa atcgatcctc 5400 tcatagccag caatacagga atgcacagga ggcaaatcac tgacctttta gaccaaagta 5460 ttcaagtgca ttcccagtgc tttgtcatca cttcagacaa ccgctatatt ctcgtctgtg 5520 gcttctggga taaaagtttc agagtctatt ctacagacac aggaagattg atccaagtgg 5580 tgtttggcca ttgggatgtc gtcacttgcc ttgctcgttc tgagtcatat attgggggaa 5640 attgctacat tctctcaggg tcacgtgatg caactctttt gctgtggtat tggaatggaa 5700 atgcagtggg attggagata acccaggcag tgagactgct gctcctcggg ccattttgac 5760 cggccatgac tatgaggtca catgtgctgc ggtgtgtgcg gagctaggcc tggtgttgag 5820 tggttcacaa gaaggaccat gtctcataca ttccatgaat ggagacttgt tgaggacctt 5880 ggagggtcct gaaaactgcc tgaaaccaaa actcattcag gcttcaagag agggtcattg 5940 tgtcatattc tatgaaaacg gcctcttctg tacattcagt gtgaatggaa aactccaggc 6000 cacgatggaa acagatgata acataagagc catccagctg agccgagatg ggcagtacct 6060 gctcacagga ggagacagag gagtggtcgt ggtccggcag gtgtcggacc tcaagcagct 6120 ctttgcctat ccaggatgtg acgctggaat ccgggccatg gcgctgtctt acgaccagag 6180 gtgcatcatt tctggcatgg cttcaggaag cattgtgcta ttttacaaca ctttaaccgg 6240 tggcatcatg ataccaaacc cgctactgat ggtgacagct gtacatcaac tctgccccta 6300 ggatgagcag aagtacctgg agcataattc tcttctacca catctgaatg taacttaaat 6360 ttgctcaaag aagcaaaata ttttttaaag ttattaataa ttgctatttt tgtagtcttt 6420 gcttgacttt tttggggggg attagcaaag cagaaaactg gctgctgggt tctgtagttt 6480 taaaaaatct atatttttag tcataatgag aagtctattt tcaccaatta tggaaacata 6540 cagtggagca agtaaaccac ttattccagc tataatatta tgaagaacat ttcccatgca 6600 tctacaagct tgagaaatag gattttcaca gtggggaagt gggttacaat attggaatag 6660 gaaaatttga tgctgtaatt tgggtcctgt atttttccaa acaactgtgc ttcttcagca 6720 ctaatatttc tgggatttaa atagtaatgt ttaaattatg gtaaatgtaa tttaaaacat 6780 ctcaattaag tctgtctatc aatattgttc ttcaagcatg ttttagacct agaaaagtat 6840 ggtttggggg aggctatttt attgtgtggt tagcacaagg aatctaattt atagcaagtg 6900 tgaaatagtt accatttttt cctgatctgt catcttcata gcacaacaaa acgaaatgat 6960 ggaaatgctc ttgagctcac aacatttgtt tttcttttaa agtaaatgca agtaccaaag 7020 ctcactactg cggtttgcct gtgcctggac aatgaggcgg agccactgtt gttggggcac 7080 ccccttccct ccccgggttt gcaaatagag gctaccgggt gctgtattca gcaacacctg 7140 ttttactatt tgttattaaa ctatcatctc caccttcctt ttgattagca atttgtacta 7200 agaaacgaaa caatgttatt tggtggtgta taattctact tttctagtag attactgtgt 7260 ggaattctgt gaaaaatatt tgagaaaagg cctgtattgc ataaataaat tctttgtatg 7320 ttgtgaaaaa aa 7332 <210> 45 <211> 1427 <212> DNA <213> Homo sapiens <400> 45 ctgggaatat gattatgctt aatctatgct cagtcgaaag gggctggggc tgctttctcc 60 cctcccttct tgactctctg ttcacagaac tcaggctgcc tccagccagc ctttgcccgc 120 tagactcact ggccctgagc acttgaaggt gcagcaagtc actgagaatg agcactttct 180 tctcggacac agcatggatc tgcctggctg tccccacagt actatgtggg acagtatttt 240 gcaaatacaa gaagagctca gggcagctgt ggagctggat ggtctgcctg gcaggcctct 300 gtgcagtctg cctgctcatc ctgtcccctt tttggggctt gatcctcttc tcggtgtcat 360 gcttcctcat gtatacttac ttatctggcc aagaattgtt acctgtggat cagaaggcag 420 tcctggtgac aggtggtgat tgcgggcttg gccatgcttt gtgcaagtat ctggatgagc 480 tgggcttcac ggtatttgcc ggagttttga atgaaaatgg cccaggagct gaggaattgc 540 gaagaacctg ctctccgcgc ctctcggtgc tccaaatgga catcacgaag ccagtgcaga 600 taaaagatgc ttacagcaag gttgcagcaa tgctgcagga cagaggactg tgggctgtga 660 tcaacaatgc tggggtgctt ggctttccaa ctgatgggga gcttcttctt atgactgact 720 acaaacaatg catggccgtg aacttctttg gaactgtgga ggtcacaaag acgtttttgc 780 ctcttcttag aaaatccaaa gggaggctgg tgaatgtcag cagcatggga ggaggggccc 840 caatggaaag gctggcatct tatggctcat caaaggcggc tgtgaccatg ttctcatcag 900 ttatgagact ggagctttcc aagtggggaa ttaaagttgc ttccatccaa cctggaggct 960 tcctaacaaa tatcgcaggc accagtgaca agtgggaaaa gctggagaag gacattctgg 1020 accacctccc cgctgaggta caggaagact acggccagga ctacatctta gcacagcgga 1080 atttcctcct attgatcaac tcgttagcca gcaaggactt ctctccggtg ctgcgggaca 1140 tccagcatgc tatcttggcg aagagccctt ttgcctatta cacgccaggg aaaggcgctt 1200 acttgtggat ctgccttgct cactatttgc ctattggcat atatgattac tttgctaaaa 1260 gacattttgg ccaagacaag cccatgccca gagctctaag aatgcctaac tacaagaaaa 1320 aggccaccta ggcaatggaa gccctcaaag aagtcggaat gtcatagtct tgaaatgaaa 1380 gggaaactgg gaaactgggt ttctcattaa agttgtttcc cactctg 1427 <210> 46 <211> 580 <212> DNA <213> Homo sapiens <400> 46 ccgagaggtg gttacattcg ttgaaggaca ccagctgcgg aatttgcggc tttggcagac 60 ccagctgagt cactgtcact gcctaccaat ctcgaccgga cctcgaccgg ctcgtctgtg 120 ctgccaatcg actcggcgtg gcgtcggtcg tggtagatag gcggtcatgc atacgaattt 180 tcagctcttg ttctggtgac cttttgaata cgtcttgtct ataaaagaaa ttcatgcctt 240 tgtaaaatac acagattgaa atcatggcag gtccagaaag tgatgcgcaa taccagttca 300 ctggtattaa aaaatatttc aactcttata ctctcacagg tagaatgaac tgtgtactgg 360 ccacatatgg aagcattgca ttgattgtct tatatttcaa gttaaggtcc aaaaaaactc 420 cagctgtgaa agcaacataa atggatttta aactgtctac ggttcttaac ctcatctgtt 480 aagttcccat gcctggagaa gctaatgcca actcatcatg tgataattca atttgtacaa 540 taaattatga acccaaaaaa aaaaaaaaaa aaaaaaaaaa 580 <210> 47 <211> 4131 <212> DNA <213> Homo sapiens <400> 47 atcccgcccg catacagccc gcatcccgcc ggggaagcga gcccagtcca gcgctgcccg 60 tccagtcctc gcccaagatt taaagcccgc aagttttgtt cttgagacca gcgactttag 120 ctccgatgcg ggaaggaaag ccgacctccg atttggacat ttaaagagct gggcttgaac 180 ttcgtgagtt tcgctctaaa ctgcccttga aatgaagctg gacttggagg tggcatggaa 240 tattcacatg ggagagccgc atgaggccgc ccaccacgct tcctgaagga tgcccgtgtg 300 gaagaatttt gacgtgccag tgtcctcgtt ctacagggtg ttccattctt ccgcaatctc 360 agaaaaatgg gactaaaaga aactattttg taaaataaga agacttccat ttttaatgac 420 caacatgtat taagatggac acctactcta cgaaacacga agttctatgg tctcgaagaa 480 gcccgtgcct gtttaaaact gatcctaact aaaaacagac ttgagtggat atgagaatgt 540 tggttagtgg cagaagagtc aaaaaatggc agttaattat tcagttattt gctacttgtt 600 ttttagcgag cctcatgttt ttttgggaac caatcgataa tcacattgtg agccatatga 660 agtcatattc ttacagatac ctcataaata gctatgactt tgtgaatgat accctgtctc 720 ttaagcacac ctcagcgggg cctcgctacc aatacttgat taaccacaag gaaaagtgtc 780 aagctcaaga cgtcctcctt ttactgtttg taaaaactgc tcctgaaaac tatgatcgac 840 gttccggaat tagaaggacg tggggcaatg aaaattatgt tcggtctcag ctgaatgcca 900 acatcaaaac tctgtttgcc ttaggaactc ctaatccact ggagggagaa gaactacaaa 960 gaaaactggc ttgggaagat caaaggtaca atgatataat tcagcaagac tttgttgatt 1020 ctttctacaa tcttactctg aaattactta tgcagttcag ttgggcaaat acctattgtc 1080 cacatgccaa atttcttatg actgctgatg atgacatatt tattcacatg ccaaatctga 1140 ttgagtacct tcaaagttta gaacaaattg gtgttcaaga cttttggatt ggtcgtgttc 1200 atcgtggtgc ccctcccatt agagataaaa gcagcaaata ctacgtgtcc tatgaaatgt 1260 accagtggcc agcttaccct gactacacag ccggagctgc ctatgtaatc tccggtgatg 1320 tagctgccaa agtctatgag gcatcacaga cactaaattc aagtctttac atagacgatg 1380 tgttcatggg cctctgtgcc aataaaatag ggatagtacc gcaggaccat gtgttttttt 1440 ctggagaggg taaaactcct tatcatccct gcatctatga aaaaatgatg acatctcatg 1500 gacacttaga agatctccag gacctttgga agaatgctac agatcctaaa gtaaaaacca 1560 tttccaaagg tttttttggt caaatatact gcagattaat gaagataatt ctcctttgta 1620 aaattagcta tgtggacaca tacccttgta gggctgcgtt tatctaatag tacttgaatg 1680 ttgtatgttt tcactgtcac tgagtcaaac ctggatgaaa aaaaccttta aatgttcgtc 1740 tataccctaa gtaaaatgag gacgaaagac aaatattttg aaagcctagt ccatcagaat 1800 gtttctttga ttctagaagc tgtttaatat cacttatcta cttcattgcc taagttcatt 1860 tcaaagaatt tgtatttaga aaaggtttat attattagtg aaaacaaaac taaagggaag 1920 ttcaagttct catgtaatgc cacatatata cttgaggtgt agagatgtta ttaagaagtt 1980 ttgatgttag aataattgct tttggaaaat accaaatgaa cgtacagtac aacatttcaa 2040 ggaaatgaat atattgttag accaggtaag caagtttatt tttgttaaag agcacttggt 2100 ggaggtagta ggggcaggga aaggtcagca taggagagaa agttcatgaa tctggtaaaa 2160 cagtctcttg ttcttaagag gagatgtaga aaaatgtgta caatgttatt ataaacagac 2220 aaatcacgtc ttaccacatc catgtagcta ctggtgttag agtcattaaa ataccttttt 2280 ttgcatcttt tttcaaagtt taatgtgaac ttttagaaaa gtgattaatg ttgccctaat 2340 actttatatg tttttaatgg attttttttt aagtattaga aaatgacaca taacacgggc 2400 agctggttgc tcatagggtc cttctctagg gagaaaccat tgttaattca aataagctga 2460 ttttaatgac gttttcaact ggtttttaaa tattcaatat tggtctgtgt ttaagtttgt 2520 tatttgaatg taatttacat agaggaatat aataatggag agacttcaaa tggaaagaca 2580 gaacattaca agcctaatgt ctccataatt ttataaaatg aaatcttagt gtctaaatcc 2640 ttgtactgat tactaaaatt aacccactcc tccccaacaa ggtcttataa accacagcac 2700 tttgttccaa gttcagagtt ttaaattgag agcattaaac atcaaagtta taatatctaa 2760 aacaatttat ttttcatcaa taactgtcag aggtgatctt tattttctaa atatttcaaa 2820 cttgaaaaca gagtaaaaaa gtgatagaaa agttgccagt ttggggttaa agcattttta 2880 aagctgcatg ttccttgtaa tcaaagagat gtgtctgaga tctaatagag taagttacat 2940 ttattttaca aagcaggata aaaatgtggc tataatacac actacctccc ttcactacag 3000 aaagaactag gtggtgtcta ctgctaggga gattatatga aggccaaaat aatgacttca 3060 gcaagagtga ctgaactcac tctaaggcct ttgactgcag aggcacctgt tagggaaaat 3120 cagatgtctc atataataag gtgatgtcgg aaacacgcaa aacaaaacga aaaaagattt 3180 ctcagtatac acaactgaat gatgatactt acaattttta gcaggtagct ttttaatgtt 3240 tacagaaatt ttaatttttt tctattttga aatttgaggc ttgtttacat tgcttagata 3300 atttagaatt tttaactaat gtcaaaacta cagtgtcaaa cattctaggt tgtagttact 3360 ttcagagtag atacagggtt ttagatcatt acagtttaag ttttctgacc aattaaaaaa 3420 acatagagaa caaaagcata tttgaccaag caacaagctt ataattaatt tttattagtt 3480 gattgattaa tgatgtattg ccttttgccc atatataccc tgtgtatcta tacttggaag 3540 tgtttaaggt tgccattggt tgaaaacata agtgtctctg gccatcaaag tgatcttgtt 3600 tacagcagtg cttttgtgaa acaattattt atttgctgaa agagctcttc tgaactgtgt 3660 ccttttaatt tttgcttaga atagaatgga acaagtttaa atttcaagga aatatgaagg 3720 cacttccttt ttttctaaga aggaagttgc tagatgattc cttcatcaca cttacttaaa 3780 gtactgagaa gagtatctgt aaataaaagg gttccaacct tttaaaaaag aaggaaaaaa 3840 ctttttggtg ctccagtgta gggctatctt tttaaaaaat gtcaacaaag ggaaaataaa 3900 ctatcagctt ggatggtcac ttgaatagaa gatggttata cacagtgtta ttgttaaaat 3960 ttttttacct tttggttggt ttgcatcttt tttccatatt gttaatttta taccaaaatg 4020 ttaaatattt gtattacttg aattttgctc ttgtatggca aaataattag tgagtttaaa 4080 aaaaatctat agtttccaat aaacaactga aaaattatca tgaaaaaaaa a 4131 <210> 48 <211> 2859 <212> DNA <213> Homo sapiens <400> 48 ctttccgcgg cattctttgg gcgtgagtca tgcaggtttg cagccagccc caaagggggt 60 gtgtgcgcga gcagagcgct ataaatacgg cgcctcccag tgcccacaac gcggcgtcgc 120 caggaggagc gcgcgggcac agggtgccgc tgaccgaggc gtgcaaagac tccagaattg 180 gaggcatgat gaagactctg ctgctgtttg tggggctgct gctgacctgg gagagtgggc 240 aggtcctggg ggaccagacg gtctcagaca atgagctcca ggaaatgtcc aatcagggaa 300 gtaagtacgt caataaggaa attcaaaatg ctgtcaacgg ggtgaaacag ataaagactc 360 tcatagaaaa aacaaacgaa gagcgcaaga cactgctcag caacctagaa gaagccaaga 420 agaagaaaga ggatgcccta aatgagacca gggaatcaga gacaaagctg aaggagctcc 480 caggagtgtg caatgagacc atgatggccc tctgggaaga gtgtaagccc tgcctgaaac 540 agacctgcat gaagttctac gcacgcgtct gcagaagtgg ctcaggcctg gttggccgcc 600 agcttgagga gttcctgaac cagagctcgc ccttctactt ctggatgaat ggtgaccgca 660 tcgactccct gctggagaac gaccggcagc agacgcacat gctggatgtc atgcaggacc 720 acttcagccg cgcgtccagc atcatagacg agctcttcca ggacaggttc ttcacccggg 780 agccccagga tacctaccac tacctgccct tcagcctgcc ccaccggagg cctcacttct 840 tctttcccaa gtcccgcatc gtccgcagct tgatgccctt ctctccgtac gagcccctga 900 acttccacgc catgttccag cccttccttg agatgataca cgaggctcag caggccatgg 960 acatccactt ccatagcccg gccttccagc acccgccaac agaattcata cgagaaggcg 1020 acgatgaccg gactgtgtgc cgggagatcc gccacaactc cacgggctgc ctgcggatga 1080 aggaccagtg tgacaagtgc cgggagatct tgtctgtgga ctgttccacc aacaacccct 1140 cccaggctaa gctgcggcgg gagctcgacg aatccctcca ggtcgctgag aggttgacca 1200 ggaaatacaa cgagctgcta aagtcctacc agtggaagat gctcaacacc tcctccttgc 1260 tggagcagct gaacgagcag tttaactggg tgtcccggct ggcaaacctc acgcaaggcg 1320 aagaccagta ctatctgcgg gtcaccacgg tggcttccca cacttctgac tcggacgttc 1380 cttccggtgt cactgaggtg gtcgtgaagc tctttgactc tgatcccatc actgtgacgg 1440 tccctgtaga agtctccagg aagaacccta aatttatgga gaccgtggcg gagaaagcgc 1500 tgcaggaata ccgcaaaaag caccgggagg agtgagatgt ggatgttgct tttgcaccta 1560 cgggggcatc tgagtccagc tccccccaag atgagctgca gccccccaga gagagctctg 1620 cacgtcacca agtaaccagg ccccagcctc caggccccca actccgccca gcctctcccc 1680 gctctggatc ctgcactcta acactcgact ctgctgctca tgggaagaac agaattgctc 1740 ctgcatgcaa ctaattcaat aaaactgtct tgtgagctga tcgcttggag ggtcctcttt 1800 ttatgttgag ttgctgcttc ccggcatgcc ttcattttgc tatggggggc aggcaggggg 1860 gatggaaaat aagtagaaac aaaaaagcag tggctaagat ggtataggga ctgtcatacc 1920 agtgaagaat aaaagggtga agaataaaag ggatatgatg acaaggttga tccacttcaa 1980 gaattgcttg ctttcaggaa gagagatgtg tttcaacaag ccaactaaaa tatattgctg 2040 caaatggaag cttttctgtt ctattataaa actgtcgatg tattctgacc aaggtgcgac 2100 aatctcctaa aggaatacac tgaaagttaa ggagaagaat cagtaagtgt aaggtgtact 2160 tggtattata atgcataatt gatgttttcg ttatgaaaac atttggtgcc cagaagtcca 2220 aattatcagt tttatttgta agagctattg cttttgcagc ggttttattt gtaaaagctg 2280 ttgatttcga gttgtaagag ctcagcatcc caggggcatc ttcttgactg tggcatttcc 2340 tgtccaccgc cggtttatat gatcttcata cctttccctg gaccacaggc gtttctcggc 2400 ttttagtctg aaccatagct gggctgcagt accctacgct gccagcaggt ggccatgact 2460 acccgtggta ccaatctcag tcttaaagct caggcttttc gttcattaac attctctgat 2520 agaattctgg tcatcagatg tactgcaatg gaacaaaact catctggctg catcccaggt 2580 gtgtagcaaa gtccacatgt aaatttatag cttagaatat tcttaagtca ctgtcccttg 2640 tctctctttg aagttataaa caacaaactt aaagcttagc ttatgtccaa ggtaagtatt 2700 ttagcatggc tgtcaaggaa attcagagta aagtcagtgt gattcactta atgatataca 2760 ttaattagaa ttatggggtc agaggtattt gcttaagtga tcataattgt aaagtatatg 2820 tcacattgtc acattaatgt caaaaaaaaa aaaaaaaaa 2859 <210> 49 <211> 1285 <212> DNA <213> Homo sapiens <400> 49 ataagacttt tatggatgga ttgtttttct caaataatat tatcgctttg tgactaaagt 60 aaagattatt aattcctgag gcaagaagat ataaaagctc cagaaacgtt gactgggacc 120 actggagaca ctgaagaagg caggggccct tagagtcttg gttgccaaac agatttgcag 180 atcaaggaga acccaggagt ttcaaagaag cgctagtaag gtctctgaga tccttgcact 240 agctacatcc tcagggtagg aggaagatgg cttccagaag catgcggctg ctcctattgc 300 tgagctgcct ggccaaaaca ggagtcctgg gtgatatcat catgagaccc agctgtgctc 360 ctggatggtt ttaccacaag tccaattgct atggttactt caggaagctg aggaactggt 420 ctgatgccga gctcgagtgt cagtcttacg gaaacggagc ccacctggca tctatcctga 480 gtttaaagga agccagcacc atagcagagt acataagtgg ctatcagaga agccagccga 540 tatggattgg cctgcacgac ccacagaaga ggcagcagtg gcagtggatt gatggggcca 600 tgtatctgta cagatcctgg tctggcaagt ccatgggtgg gaacaagcac tgtgctgaga 660 tgagctccaa taacaacttt ttaacttgga gcagcaacga atgcaacaag cgccaacact 720 tcctgtgcaa gtaccgacca tagagcaaga atcaagattc tgctaactcc tgcacagccc 780 cgtcctcttc ctttctgcta gcctggctaa atctgctcat tatttcagag gggaaaccta 840 gcaaactaag agtgataagg gccctactac actggctttt ttaggcttag agacagaaac 900 tttagcattg gcccagtagt ggcttctagc tctaaatgtt tgccccgcca tccctttcca 960 cagtatcctt cttccctcct cccctgtctc tggctgtctc gagcagtcta gaagagtgca 1020 tctccagcct atgaaacagc tgggtctttg gccataagaa gtaaagattt gaagacagaa 1080 ggaagaaact caggagtaag cttctagacc ccttcagctt ctacaccctt ctgccctctc 1140 tccattgcct gcaccccacc ccagccactc aactcctgct tgtttttcct ttggccatag 1200 gaaggtttac cagtagaatc cttgctaggt tgatgtgggc catacattcc tttaataaac 1260 cattgtgtac ataagaaaaa aaaaa 1285 <210> 50 <211> 5205 <212> DNA <213> Homo sapiens <400> 50 gagccgccgc cgggtcccgc tcgtctgccg cctcagcctc agccccaacc tcagccgccg 60 ccgttgcgct tgctcccggg cggtcctggc ctgtgccgcc gccgccccca gcgtcggagc 120 catggcgggc gccgcgtccc cttgcgccaa cggctgcggg cccggcgcgc cctcggacgc 180 cgaggtgctg cacctctgcc gcagcctcga ggtgggcacc gtcatgactt tgttctactc 240 caagaagtcg cagcgacccg agcggaagac cttccaggtc aagctggaga cgcgccagat 300 cacgtggagc cggggcgccg acaagatcga gggggccatt gacattcgtg aaattaagga 360 gatccgccca gggaagacct cacgggactt tgatcgctat caagaggacc cagctttccg 420 gccggaccag tcacattgct ttgtcattct ctatggaatg gaatttcgcc tgaaaacgct 480 gagcctgcaa gccacatctg aggatgaagt gaacatgtgg atcaagggct taacttggct 540 gatggaggat acattgcagg cacccacacc cctgcagatt gagaggtggc tccggaagca 600 gttttactca gtggatcgga atcgtgagga tcgtatatca gccaaggacc tgaagaacat 660 gctgtcccag gtcaactacc gggtccccaa catgcgcttc ctccgagagc ggctgacgga 720 cctggagcag cgcagcgggg acatcaccta cgggcagttt gctcagctgt accgcagcct 780 catgtacagc gcccagaaga cgatggacct ccccttcttg gaagccagta ctctgagggc 840 tggggagcgg ccggagcttt gccgagtgtc ccttcctgag ttccagcagt tccttcttga 900 ctaccagggg gagctgtggg ctgttgatcg cctccaggtg caggagttca tgctcagctt 960 cctccgagac cccttacgag agatcgagga gccatacttc ttcctggatg agtttgtcac 1020 cttcctgttc tccaaagaga acagtgtgtg gaactcgcag ctggatgcag tatgcccgga 1080 caccatgaac aaccctcttt cccactactg gatctcctcc tcgcacaaca cgtacctgac 1140 cggggaccag ttctccagtg agtcctcctt ggaagcctat gctcgctgcc tgcggatggg 1200 ctgtcgctgc attgagttgg actgctggga cggcccggat gggatgccag ttatttacca 1260 tgggcacacc cttaccacca agatcaagtt ctcagatgtc ctgcacacca tcaaggagca 1320 tgcctttgtg gcctcagagt acccagtcat cctgtccatt gaggaccact gcagcattgc 1380 ccagcagaga aacatggccc aatacttcaa gaaggtgctg ggggacacac tcctcaccaa 1440 gcccgtggag atctctgccg acgggctccc ctcacccaac cagcttaaga ggaagatcct 1500 catcaagcac aagaagctgg ctgagggcag tgcctacgag gaggtgccta catccatgat 1560 gtactctgag aacgacatca gcaactctat caagaatggc atcctctacc tggaggaccc 1620 tgtgaaccac gaatggtatc cccactactt tgttctgacc agcagcaaga tctactactc 1680 tgaggagacc agcagtgacc agggcaacga ggatgaggag gagcccaagg aggtcagcag 1740 cagcacagag ctgcactcca atgagaagtg gttccatggg aagctagggg cagggcgtga 1800 cgggcgtcac atcgctgagc gcctgcttac tgagtactgc atcgagaccg gagcccctga 1860 cggctccttc ctcgtgcgag agagtgagac cttcgtgggc gactacacgc tctctttctg 1920 gcggaacggg aaagtccagc actgccgtat ccactcccgg caagatgctg ggacccccaa 1980 gttcttcttg acagacaacc tcgtctttga ctccctctat gacctcatca cgcactacca 2040 gcaggtgccc ctgcgctgta atgagtttga gatgcgactt tcagagcctg tcccacagac 2100 caacgcccac gagagcaaag agtggtacca cgcgagcctg accagagcac aggctgagca 2160 catgctaatg cgcgtccctc gtgatggggc cttcctggtg cggaagcgga atgaacccaa 2220 ctcatatgcc atctctttcc gggctgaggg caagatcaag cattgccgtg tccagcaaga 2280 gggccagaca gtgatgctag ggaactcgga gttcgacagc cttgttgacc tcatcagcta 2340 ctatgagaaa cacccgctat accgcaagat gaagctgcgc tatcccatca acgaggaggc 2400 actggagaag attggcacag ctgagcctga ctacggggcc ctgtatgagg gacgcaaccc 2460 tggcttctat gtagaggcaa accctatgcc aactttcaag tgtgcagtca aagccctctt 2520 tgactacaag gcccagaggg aggacgagct gaccttcatc aagagcgcca tcatccagaa 2580 tgtggagaag caagagggag gctggtggcg aggggactac ggagggaaga agcagctgtg 2640 gttcccatca aactacgtgg aagagatggt caaccccgtg gccctggagc cggagaggga 2700 gcacttggac gagaacagcc ccctagggga cttgctgcgg ggggtcttgg atgtgccggc 2760 ttgtcagatt gccatccgtc ctgagggcaa gaacaaccgg ctcttcgtct tctccatcag 2820 catggcgtcg gtggcccact ggtccctgga tgttgctgcc gactcacagg aggagctgca 2880 ggactgggtg aaaaagatcc gtgaagtggc ccagacagca gacgccaggc tcactgaagg 2940 gaagataatg gaacggagga agaagattgc cctggagctc tctgaacttg tcgtctactg 3000 ccggcctgtt ccctttgatg aagagaagat tggcacagaa cgtgcttgct accgggacat 3060 gtcatccttc ccggaaacca aggctgagaa atacgtgaac aaggccaaag gcaagaagtt 3120 ccttcagtac aatcgactgc agctctcccg catctacccc aagggccagc gactggattc 3180 ctccaactac gatcctttgc ccatgtggat ctgtggcagt cagcttgtgg ccctcaactt 3240 ccagacccct gacaagccta tgcagatgaa ccaggccctc ttcatgacgg gcaggcactg 3300 tggctacgtg ctgcagccaa gcaccatgcg ggatgaggcc ttcgacccct ttgacaagag 3360 cagcctccgc gggctggagc catgtgccat ctctattgag gtgctggggg cccgacatct 3420 gccaaagaat ggccgaggca ttgtgtgtcc ttttgtggag attgaggtgg ctggagctga 3480 gtatgacagc accaagcaga agacagagtt tgtggtggac aatggactca accctgtatg 3540 gccagccaag cccttccact tccagatcag taaccctgaa tttgcctttc tgcgcttcgt 3600 ggtgtatgag gaagacatgt ttagtgacca gaatttcctg gctcaggcta ctttcccagt 3660 aaaaggcctg aagacaggat acagagcagt gcctttgaag aacaactaca gtgaggacct 3720 ggagttggcc tccctgctga tcaagattga cattttccct gccaagcagg agaatggtga 3780 cctcagtccc ttcagtggta cgtccctgcg ggagcggggc tcagatgcct caggccagct 3840 gtttcatggc cgagcccggg aaggctcctt tgaatcccgc taccagcagc cgtttgagga 3900 cttccgcatc tcccaggagc atctcgcaga ccattttgac agtcgagaac gaagggcccc 3960 aagaaggact cgggtcaatg gagacaaccg cctctagttg taccccagcc tcgttggaga 4020 gcagcaggtg ctgtgcgcct tgtagaatgc cgcgaactgg gttctttgga agcagccccc 4080 tgtggcggcc ttccgggtct cgcagcctga agcctggatt ccagcagtga atgctagaca 4140 gaaaccaagc cattaatgag atgttattac tgttttgggc ctccatgccc cagctctgga 4200 tgaaggcaaa aactgtactg tgtttcgcat taagcacaca catctggccc tgacttctgg 4260 agatggatcc ttccatcttg tggggccagg accatggccg aagccccttg gagagagagg 4320 ctgcctcagc cagtggcaca ggagactcca aggagctact gacattccta agagtggagg 4380 aggaggagga gccttgctgg gccagggaaa caaagtttac attgtcctgt agctttaaaa 4440 ccacagctgg gcagggtgag aagctagatg cccctgcagt ttggccctgg agccagggca 4500 gaggaatgta gggcctgcat ggagaagggt tctgccctgc ctgaggagga ggacacagca 4560 caagggcaca ttgcccatgg ctgggaacat gacccagcct gaaagataca ggggatcatg 4620 ttaaaaatag cagtattatt tttcgtctca atggtattgt aactaagtta tttactcctc 4680 ctgctcctca cccctgtagg gaaaccttgg agaggagagt ggcaggtggg ctgcctgctg 4740 tgttaagagg acttagtttg tgatgtaagg cactgtcagg aatggggggc gggccagggt 4800 gggaagagaa gaaatagcag agcctatttt ggtgaggttt tttgttttta agtcaaagaa 4860 gactcagtat gctttccctg aggaatgaaa aagggattga ggagttgcct gactcctggg 4920 tgggtggggt acaggcagtt aggtgctgaa tgaagctgcc atccttgctg cagcttctaa 4980 ctggtaaaaa gatccaggga tggagatggg aaggttagaa aggcagccct cacctctgag 5040 gacagaggcc ggggtccagg cccgtgggcg caaaggtgcc tcatagcata gccagcattc 5100 agcacacaca aacctactgc ccacatttgg gctcagggtt ggccatttgc tagttctgct 5160 gccctcttaa gatctgactg ccaaataaat catcctcatg tcctt 5205

Claims (7)

1) NM_016208 (VPS28 protein; 서열번호 1)

2) NM_005147 (tumorous imaginal discs (Drosophila) homolog; 서열번호 2)

3) NM_016334 (putative G-protein coupled receptor; 서열번호 3)

4) NM_003392 (wingless-type MMTV integration site family, member 5A; 서열번호 4)

5) NM_002933 (ribonuclease, RNase A family, 1 (pancreatic); 서열번호 5)

6) NM_007271 (serine threonine protein kinase; 서열번호 6)

7) NM_001540 (heat shock 27kD protein 1; 서열번호 7)

8) AK026164 (cDNA: FLJ22511 fis, clone HRC11837, highly similar to HUMMYLCB Human non-muscle myosin alkali light chain; 서열번호 8)

9) NM_002305 (lectin, galactoside-binding, soluble, 1; 서열번호 9)

10) AW015185 (UI-H-BI0-aap-a-03-0-UI.s1 cDNA, 3' end; 서열번호 10)

11) BG679661 (602626518F1 cDNA, 5' end; 서열번호 11)

12) AB067484 (mRNA for KIAA1897 protein, partial cds; 서열번호 12)

13) U47077 (DNA-dependent protein kinase catalytic subunit; 서열번호 13)

14) AA878376 (oe65b04.s1 cDNA, 3' end; 서열번호 14)

15) NM_004336 (budding uninhibited by benzimidazoles 1 (yeast homolog); 서열번호 15)

16) NM_016219 (alpha 1,2-mannosidase; 서열번호 16)

17) W67867 (zd38e07.r1 cDNA, 5' end; 서열번호 17)

18) NM_003254 (tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); 서열번호 18)

19) NM_000477 (albumin; 서열번호 19)

20) NM_001068 (topoisomerase (DNA) II beta (180kD); 서열번호 20)

21) NM_004935 (cyclin-dependent kinase 5; 서열번호 21)

22) NM_014708 (KIAA0166 gene product; 서열번호 22)

23) NM_005620 (S100 calcium-binding protein A11 (calgizzarin); 서열번호 23)

24) NM_002106 (H2A histone family, member Z); 서열번호 24)

25) NM_002875 (RAD51 (S. cerevisiae) homolog (E coli RecA homolog); 서열번호 25)

26) NM_002648 (pim-1 oncogene; 서열번호 26)

27) NM_004270 (cofactor required for Sp1 transcriptional activation, subunit 9; 서열번호 27)

28) AF196969 (phenylalkylamine binding protein gene; 서열번호 28)

29) AB029031 (mRNA for KIAA1108 protein; 서열번호 29)

30) BE883627 (601507306F1 cDNA, 5' end; 서열번호 30)

31) NM_005423 (trefoil factor 2 (spasmolytic protein 1); 서열번호 31)

32) AF217536 (truncated mevalonate kinase mRNA; 서열번호 32)

33) NM_033418 (hypothetical protein MGC9084; 서열번호 33)

34) BC001209 (Homo sapiens, clone MGC:3214 IMAGE:3502620; 서열번호 34)

35) NM_012406 (PR domain containing 4; 서열번호 35)

36) BI551315 (603193129F1 cDNA, 5' end; 서열번호 36)

37) BI439120 (ic26g10.y3 cDNA, 5' end; 서열번호 37)

38) NM_032300 (hypothetical protein MGC10854; 서열번호 38)

39) D17525 (precursor of P100 serine protease of Ra-reactive factor; 서열번호 39)

40) NM_025245 (pre-B-cell leukemia transcription factor 4; 서열번호 40)

41) NM_017571 (hypothetical protein (LOC55580); 서열번호 41)

42) NM_016565 (E2IG2 protein (LOC51287); 서열번호 42)

43) NM_002938 (ring finger protein 4; 서열번호 43)

44) M83822 (Human beige-like protein; 서열번호 44)

45) NM_002153 (hydroxysteroid (17-beta) dehydrogenase 2; 서열번호 45)

46) NM_032747 (hypothetical protein MGC14697; 서열번호 46)

47) NM_032047 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; 서열번호 47)

48) NM_001831 (clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J; 서열번호 48)

49) NM_032044 (regenerating gene type IV; 서열번호 49) 및

50) NM_002660 (phospholipase C, gamma 1; 서열번호 50)

의 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 키트.

제 1 항에 있어서,

상기 서열번호 1 내지 50의 폴리뉴클레오티드 세트를 포함하는 것을 특징으로 하는 키트.

삭제

제 1 항 또는 제2항에 있어서,

상기 서열번호 1 내지 50의 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드의 센스 및 안티센스 프라이머, 상기 폴리뉴클레오티드에 상보적인 프로브, 및 상기 폴리뉴클레오티드에 의해 코딩되는 단백질을 인식하는 항체로 이루어진 군으로부터 선택되는 하나 이상을 포함하는 것을 특징으로 하는 키트.

제 1 항 또는 제 2 항에 따른 폴리뉴클레오티드 또는 상기 폴리뉴클레오티드에 의해 코딩되는 단백질을 인식하는 항체를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측할 수 있는 마이크로어레이.

자궁암 세포로부터 서열번호 1 내지 50의 폴리뉴클레오티드로 구성된 군으로부터 선택되는 하나 이상의 폴리뉴클레오티드의 발현 수준을 측정하는 단계; 및

상기 측정된 발현 수준을 정상 세포에서의 상기 폴리뉴클레오티드의 발현 수준과 비교함으로써 방사선 치료를 받은 자궁암 환자의 재발을 예측하기 위해, 상기 측정된 발현 수준을 제공하는 단계를 포함하는, 자궁암으로 방사선 치료를 받은 사람의 치료 후 재발을 예측하기 위한 정보를 제공하는 방법.

제 6 항에 있어서, 상기 폴리뉴클레오티드는 서열번호 1 내지 50의 폴리뉴클레오티드 세트인 것을 특징으로 하는 방법.

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