KR100891438B1 - 무스카린 길항제와 선택된 오피오이드와의 배합물 및 이를 포함하는 요실금 치료용 약제학적 조성물 - Google Patents

무스카린 길항제와 선택된 오피오이드와의 배합물 및 이를 포함하는 요실금 치료용 약제학적 조성물 Download PDF

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Publication number
KR100891438B1
KR100891438B1 KR1020047004002A KR20047004002A KR100891438B1 KR 100891438 B1 KR100891438 B1 KR 100891438B1 KR 1020047004002 A KR1020047004002 A KR 1020047004002A KR 20047004002 A KR20047004002 A KR 20047004002A KR 100891438 B1 KR100891438 B1 KR 100891438B1
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South Korea
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alkyl
unsubstituted
compound
saturated
phenyl
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Korean (ko)
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KR20040044953A (ko
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크리스토프토마스
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그뤼넨탈 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020047004002A 2001-09-18 2002-09-18 무스카린 길항제와 선택된 오피오이드와의 배합물 및 이를 포함하는 요실금 치료용 약제학적 조성물 Expired - Fee Related KR100891438B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10146275.1 2001-09-18
DE10146275A DE10146275A1 (de) 2001-09-18 2001-09-18 Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
PCT/EP2002/010460 WO2003024444A1 (de) 2001-09-18 2002-09-18 Kombination ausgewählter opioide mit muscarin-antagonisten zur therapie der harninkontinenz

Publications (2)

Publication Number Publication Date
KR20040044953A KR20040044953A (ko) 2004-05-31
KR100891438B1 true KR100891438B1 (ko) 2009-04-03

Family

ID=7699618

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047004002A Expired - Fee Related KR100891438B1 (ko) 2001-09-18 2002-09-18 무스카린 길항제와 선택된 오피오이드와의 배합물 및 이를 포함하는 요실금 치료용 약제학적 조성물

Country Status (21)

Country Link
US (2) US20040242617A1 (https=)
EP (1) EP1429754B1 (https=)
JP (1) JP4511176B2 (https=)
KR (1) KR100891438B1 (https=)
CN (1) CN100384413C (https=)
AT (1) ATE383854T1 (https=)
AU (1) AU2002342707B2 (https=)
BR (1) BR0212714A (https=)
CA (1) CA2460655C (https=)
DE (2) DE10146275A1 (https=)
EC (1) ECSP045025A (https=)
ES (1) ES2299608T3 (https=)
HU (1) HUP0401485A3 (https=)
IL (2) IL160894A0 (https=)
MX (1) MXPA04002510A (https=)
NO (1) NO333016B1 (https=)
NZ (1) NZ531777A (https=)
PL (1) PL209272B1 (https=)
RU (1) RU2305562C2 (https=)
WO (1) WO2003024444A1 (https=)
ZA (1) ZA200402853B (https=)

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DE10146275A1 (de) 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
DE10224108A1 (de) * 2002-05-29 2004-01-29 Grünenthal GmbH 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes Arzneimiitel mit verzögerter Wirkstofffreisetzung
US7410965B2 (en) 2002-05-29 2008-08-12 Gruenenthal Gmbh Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol
DE10224556A1 (de) * 2002-05-31 2004-01-08 Grünenthal GmbH 1-Dimethylamino- 3-(3-methoxy-phenyl)2-methyl-pentan-3-ol entaltendes Arzneimittel in verschiedenen Formulierungen
ES2288641T3 (es) * 2002-12-20 2008-01-16 Dynogen Pharmaceuticals Inc. Metodo para tratar trastornos indoloros de la vejiga usando moduladores de canales del calcio de la subunidad alfa2-delta.
DE602004003172T2 (de) * 2003-03-21 2007-09-27 Dynogen Pharmaceuticals Inc., Waltham Verfahren zur behandlung von erkrankungen der unteren harnwege mit antimuskarinika und mit modulatoren der alpha-2-delta untereinheit des kalziumkanals
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen
AU2005245403B2 (en) * 2004-05-14 2012-04-19 Janssen Pharmaceutica N.V. Carboxamido opioid compounds
DE102005009217A1 (de) * 2005-02-25 2006-08-31 Grünenthal GmbH Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen
US20070032551A1 (en) * 2005-07-22 2007-02-08 Gruenenthal Gmbh Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
JP5323480B2 (ja) * 2005-07-22 2013-10-23 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−［２−（ジメチルアミノ）メチル−（シクロヘキシ−１−イル）］−フェノールのＨＣｌ多形体
US7884247B2 (en) * 2005-07-22 2011-02-08 Gruenenthal Gmbh Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
DE102007022790A1 (de) 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur Schmerzbehandlung bei Arthrose
BRPI0921725A2 (pt) * 2008-10-30 2016-01-05 Grüenthal GmbH formas de dosagem potentes do tapentadol
WO2011110595A1 (de) 2010-03-10 2011-09-15 Grünenthal GmbH Kristalline salze und/oder cokristalle von o-desmethyltramadol
CA2798884C (en) 2010-05-10 2016-09-13 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
AU2011252039B2 (en) 2010-05-10 2014-06-12 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
CN103002881B (zh) 2010-05-10 2015-09-02 欧洲凯尔特公司 载有活性剂的颗粒与额外活性剂的组合
CN103040828B (zh) * 2013-01-07 2015-12-02 常州康普药业有限公司 复方地芬诺酯片及其制备方法
WO2015071380A1 (en) 2013-11-13 2015-05-21 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Citations (2)

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GB857194A (en) * 1957-07-05 1960-12-29 Clinical Products Ltd Therapeutic agents comprising ion-exchange resins
DE3129982A1 (de) * 1981-07-29 1983-02-17 Jutta 8200 Rosenheim Meyer "antiallergikum"

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NL127065C (https=) 1964-04-22
US5736577A (en) 1995-01-31 1998-04-07 Sepracor, Inc. Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin
DE3012837A1 (de) * 1979-04-10 1980-10-30 Sandoz Ag Analgetische und myotonolytische praeparate
US5073560A (en) 1990-07-20 1991-12-17 Fisons Corporation Spiro-isoxazolidine derivatives as cholinergic agents
DE4041559A1 (de) 1990-12-22 1992-06-25 Boehringer Ingelheim Kg Neue wirkstoffkombinationen
SE9202218D0 (sv) * 1992-07-22 1992-07-22 Kabi Pharmacia Ab Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
CN1054850C (zh) * 1993-07-30 2000-07-26 德尔塔药物公司 用于治疗的哌嗪化合物
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE69631525T2 (de) * 1995-03-03 2004-12-16 Endo Pharmaceuticals Inc. Verwendung von dextromethorphan oder dextrorphan zur behandlung der harninkontinenz
DE19525137C2 (de) 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
JP2000515525A (ja) 1996-07-19 2000-11-21 アベーグ，グンナー 尿と胃腸の疾患の治療におけるｓ（―）―トルテロジン
EP1005861B1 (en) * 1997-04-11 2005-06-29 Nippon Shinyaku Co., Ltd. Remedies for frequent urination and urinary incontinence
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
PT1257277E (pt) * 2000-02-24 2005-09-30 Pharmacia & Upjohn Co Llc Novas combinacoes de farmacos
DE10059412A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz
DE10146275A1 (de) 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB857194A (en) * 1957-07-05 1960-12-29 Clinical Products Ltd Therapeutic agents comprising ion-exchange resins
DE3129982A1 (de) * 1981-07-29 1983-02-17 Jutta 8200 Rosenheim Meyer "antiallergikum"

Also Published As

Publication number Publication date
CA2460655A1 (en) 2003-03-27
CN100384413C (zh) 2008-04-30
WO2003024444A1 (de) 2003-03-27
HUP0401485A3 (en) 2008-04-28
DE50211566D1 (de) 2008-03-06
NZ531777A (en) 2006-11-30
IL160894A0 (en) 2004-08-31
ATE383854T1 (de) 2008-02-15
ES2299608T3 (es) 2008-06-01
RU2004111788A (ru) 2005-06-10
EP1429754B1 (de) 2008-01-16
JP4511176B2 (ja) 2010-07-28
AU2002342707B2 (en) 2006-10-12
EP1429754A1 (de) 2004-06-23
PL369235A1 (en) 2005-04-18
NO20041059L (no) 2004-05-12
RU2305562C2 (ru) 2007-09-10
BR0212714A (pt) 2004-08-03
ZA200402853B (en) 2005-02-23
HUP0401485A2 (hu) 2004-11-29
NO333016B1 (no) 2013-02-18
HK1075205A1 (zh) 2005-12-09
JP2005507387A (ja) 2005-03-17
DE10146275A1 (de) 2003-04-24
US20120016023A1 (en) 2012-01-19
ECSP045025A (es) 2004-04-28
KR20040044953A (ko) 2004-05-31
US8946290B2 (en) 2015-02-03
IL160894A (en) 2010-04-29
MXPA04002510A (es) 2004-05-31
CA2460655C (en) 2012-02-07
US20040242617A1 (en) 2004-12-02
CN1589140A (zh) 2005-03-02
PL209272B1 (pl) 2011-08-31

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