KR100852881B1 - 숙지황, 삼칠근 또는 이들의 혼합 추출물을 유효성분으로함유하는 치주질환 예방 및 치료용 조성물 - Google Patents
숙지황, 삼칠근 또는 이들의 혼합 추출물을 유효성분으로함유하는 치주질환 예방 및 치료용 조성물 Download PDFInfo
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- KR100852881B1 KR100852881B1 KR1020070037997A KR20070037997A KR100852881B1 KR 100852881 B1 KR100852881 B1 KR 100852881B1 KR 1020070037997 A KR1020070037997 A KR 1020070037997A KR 20070037997 A KR20070037997 A KR 20070037997A KR 100852881 B1 KR100852881 B1 KR 100852881B1
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- periodontal disease
- extract
- samchil
- preventing
- sulfur
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Abstract
Description
도 2는 본 발명에 따른 혼합생약재 추출물이 종양 괴사인자-알파(TNF-α)의 유리 억제에 미치는 영향을 나타낸 그래프이다.
도 3은 본 발명에 따른 추출물의 혼합비율이 조골세포 증식에 미치는 영향을 나타낸 그래프이다.
도 4는 본 발명에 따른 추출물의 혼합비율이 조골세포의 OPG 발현에 미치는 영향을 나타낸 그래프이다.
도 5는 본 발명에 따른 혼합생약재 추출물이 조골세포의 OPG 발현에 미치는 영향을 나타낸 그래프이다.
도 6은 본 발명에 따른 추출물의 혼합비율이 파골세포의 형성에 미치는 영향을 나타낸 그래프이다.
도 7은 본 발명에 따른 혼합생약재 추출물이 파골세포의 형성에 미치는 영향을 나타낸 그래프이다.
도 8은 본 발명에 따른 추출물의 혼합비율이 파골세포 활성에 미치는 영향을 나타낸 그래프이다.
도 9는 본 발명에 따른 혼합생약재 추출물이 파골세포 활성에 미치는 영향을 나타낸 그래프이다.
도 10은 본 발명에 따른 추출물의 혼합비율이 사람 치은섬유아세포의 증식에 미치는 영향을 나타낸 그래프이다.
도 11은 본 발명에 따른 혼합생약재 추출물이 사람 치은섬유아세포의 증식에 미치는 영향을 나타낸 그래프이다.
도 12는 본 발명에 따른 추출물의 혼합비율이 사람 치주인대세포의 증식에 미치는 영향을 나타내는 그래프이다.
도 13은 본 발명에 따른 혼합생약재 추출물이 치주질환을 유발한 흰쥐의 골소실 억제에 미치는 영향을 나타내는 조직사진이다 (AC(Alveolar bone Crest)는 치조골 최상부를 나타내며, CEJ(Cemento-Enamel Junction)는 백악질-법랑질 경계를 나타낸다.).
도 14는 본 발명에 따른 혼합생약재 추출물이 치주질환을 유발한 흰쥐의 골소실 억제에 미치는 영향을 나타내는 그래프이다.
치주조직은 치조골, 치은(잇몸) 및 치주인대로 이루어져 있다. 잇몸은 우리가 입안에서 볼 수 있는 치아 지지조직의 일부분으로 여기서 질환(치은염)이 시작 되는데, 질환이 심화되어 지지조직으로 점점 깊게 퍼져나가면 치아 뿌리면과 치아를 둘러싸고 있는 뼈 조직에 결합되어 있는 치주인대가 파괴되고 치아를 싸고 있는 치조골도 파괴되면서 치주질환이 발생하게 된다.
치은염 및 치주염을 포함하는 치주질환은 세균에 의해 야기되는 치아지지 조직의 염증상태로서, 출혈, 치주낭의 형성 및 치조골의 파괴 등으로 인하여 치아의 상실을 가져오는 질환이다. 이러한 치주질환은 세균의 집락형성, 세균의 치주조직 침투 및 치주조직이 파괴되는 과정으로 진행된다. 구체적으로, 불량한 구강 위생상태로 인하여 구강 세균이 서식하면 세균막을 형성하여 염증이 생기고 가끔 잇몸에서 피가 나고 구취가 나며, 이러한 상태로 더 진행되면 치아와 잇몸 사이의 벌어진 틈이 더 깊어져서 치주낭이 생기고, 여기에 치주질환을 일으키는 세균들이 번식하여 치주염이 발생된다. 치주염이 진행되면 칫솔질과 같은 약한 자극에도 잇몸에서 피가 나기도 하며 붓고, 종종 급성염증으로 변화되어 통증을 유발한다. 이러한 염증은 골을 생성하는 기능은 저하시키고, 골을 흡수하는 기능은 증가시켜 치조골이 점점 소실되고 파괴되어 결국 치아를 상실하게 된다.
치주질환의 원인은 여러 가지가 있으나, 국소적 요인으로 치태가 치주낭 내에 축적되면 주변에 존재하는 혐기성 그람음성 세균들의 서식처가 되어, 치주낭의 심부로 증식되게 된다. 이때 증식된 혐기성 그람음성 세균의 독소 및 모든 산물이 직접 조직을 파괴하거나 면역계를 자극하여 자극된 면역계의 여러 가지 작용에 의하여 치주조직 파괴와 더불어 염증을 유발하게 된다. 이에 대한 방어기전으로 다형핵 백혈구의 기능과 면역반응이 전신적인 요인으로 작용하게 된다.
즉, 치주조직 파괴와 염증은 혐기성 그람음성 세균들의 대사 산물인 황화수소, 암모니아 및 유독한 아민과 같은 세포 독소와 혐기성 그람음성 세균들의 세포벽 구성분인 리포폴리사카라이드(Lipopolysaccharide)와 같은 내독소에 의해 직접 조직이 파괴되거나 생체 면역계를 자극하여 자극된 체액성 및 세포성 면역계의 작용으로 세포외부로 분비된 활성산소, 프로스타글란딘(Prostaglandin), 루코트리엔(Leukotrien), 히스타민(Histamine), 인터루킨(Interleuckin)등의 다양한 사이토카인(Cytokine)에 의해 유발된다. 또한 세균 및 백혈구로부터 분비된 콜라게네이즈와 같은 효소에 의하여 치주조직의 기질인 콜라젠이 분해되어 잇몸퇴축이 일어나고, 계속 방치하게 되면 치주질환으로 진행된다.
따라서, 치주질환의 근원적인 발병인자인 혐기성 그람음성 세균에 대한 항균작용, 정균작용 및 세균의 독성산물 제거 그리고 소실된 치주조직 원상회복이 치주질환의 예방 및 치료에 중요한 관건이다.
현재, 치주질환의 치료에는 환자의 구강위생 개선, 비외과적 치료 및 외과적 치료(치석제거술, 치근활택술, 치은소파술, 신부착을 응용한 치주조직의 재생술)가 이용되고 있다. 가장 효과적인 치료인 외과적 치료 방법은 치료를 위해 치과를 가야하는 번거로움과 병의 예방보다는 병이 어느 정도 진행되었을 때 행하는 한계성 때문에, 치주질환에 대한 치료가 효과적으로 이루어지지 않아 치주질환은 대부분 만성 질환으로 진행된다. 부가적인 치료로 전신적인 항생제의 복용과 국소 서방형 제재가 사용되어 왔으나, 불필요한 부위에도 약물이 너무 많이 전달되어 그로 인한 부작용과 최근 사용되는 항생제에 대한 내성을 나타내는 치주질환균이 분리된 예가 보고되고 있어 심각한 문제점을 안고 있다.
이러한 외과적 치료의 한계성과 항생제 사용의 문제점을 보완하고 치주질환 예방 및 치료효과를 향상시키기 위해서는 파괴 및 소실된 치주조직을 원상회복시키는 효능을 지닌 제제의 개발이 절실히 요구되고 있다.
Melcher에 의하면 치주조직의 재생은 재생에 관여하는 세포의 유래에 따라 차이가 있다고 한다. 뼈에서 유래된 세포가 재생에 관여하면 골유착이 일어나고, 결체조직에서 유래된 세포(치은섬유아세포 등)가 관여할 경우 치근의 흡수가 야기되며, 상피조직에서 유래된 세포가 관여하면 긴 부착상피가 생겨나게 되어 이상적인 치주조직의 재생이 일어나지 않게 되지만, 치주인대세포에서 유래된 세포가 재생에 관여할 경우 가장 이상적인 치주조직 재생이 유도된다고 한다(Melcher A.H. Journal of Periodontology, 47(5);256-260, 1976).
이런 의견을 종합할 때, 치주인대세포의 증식은 촉진시키면서, 치은섬유아세포의 증식에는 영향을 주지 않는 것이 치주조직의 재생에 가장 이상적인 도움을 줄 수 있다고 할 수 있다.
본 발명자들은 세균의 독소에 의하여 자극된 생체 면역계로부터 분비되는 여러 가지 염증성 사이토카인들(TNF-α, IFN-γ, GM-CSF, IL-2, IL-6)과 CD4+ T 세포의 활성화로 파골세포의 생성 및 활성에 결정적인 역할을 하는 오스테오프로테그린 리간드(Osteoprotegerin ligand)의 발현 증가로 파골 세포 생성(Osteoclastogenesis)이 촉진됨으로써 골 파괴가 발생한다는 사실에 근거하여, 치주질환의 치료를 위해 사이토카인 유리를 억제시켜 염증을 억제하고 조골세포 증식 촉진과 파골세포 생성 및 활성 억제를 통하여 치조골의 파괴를 막으며(Kong Y.Y. et al., Nature 402, 304-309, 1999), 치은섬유아세포의 증식에는 큰 영향을 주지 않으면서 치주인대세포의 증식은 효과적으로 증가시킬 수 있는 약제를 개발하고자 하였다.
또한, 본 발명은 숙지황 또는 삼칠근의 단독추출물, 이들의 혼합물 또는 숙지황과 삼칠근 혼합 추출물을 유효성분으로 함유하는 치주질환 예방 및 치료용 건강 식품조성물을 제공한다.
삼칠근(㎎/㎖) \ 숙지황(㎎/㎖) | 0 | 0.1 | 0.2 | 0.4 | 0.8 | 1.6 |
0 | 107.93±1.58 | 94.16±2.32 | 81.89±4.14 | 71.26±3.44 | 55.39±0.40 | 45.21±1.82 |
0.1 | 98.35±6.03 | 83.23±3.14 | 70.36±3.54 | 63.47±3.58 | 60.48±6.59 | 46.56±6.14 |
0.2 | 93.41±1.44 | 79.64±2.87 | 70.96±1.44 | 60.33±3.48 | 52.25±2.60 | 42.96±1.43 |
0.4 | 111.09±3.78 | 107.09±5.73 | 93.22±2.14 | 91.22±3.75 | 68.10±3.13 | 55.16±1.26 |
0.8 | 100.77±3.15 | 92.60±3.93 | 77.97±1.34 | 81.66±4.84 | 57.47±1.47 | 48.07±0.71 |
1.6 | 103.85±1.08 | 87.67±4.75 | 85.05±3.95 | 69.49±2.07 | 61.79±5.63 | 47.92±0.82 |
도 13 및 14에 나타난 바와 같이, 치주질환 유발 후 물만을 공급한 음성대조군의 골 소실은 정상군에 비해 3배 이상 일어난 반면 숙지황과 삼칠근 혼합 추출물을 경구 투여한 군은 정상군에 비해 2배 정도 골 소실이 나타났다.
Claims (18)
- 숙지황 단독추출물, 숙지황과 삼칠근의 단독추출물의 혼합물, 또는 숙지황과 삼칠근 혼합 추출물을 유효성분으로 함유하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 숙지황과 삼칠근 단독 추출물의 혼합물은 숙지황 단독추출물 1~16 중량부에 대하여 삼칠근 16~1 중량부인 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 숙지황과 삼칠근의 혼합추출물을 숙지황 1 중량부에 대하여 삼칠근 8 중량부의 비율로 혼합하여 추출한 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 숙지황 또는 삼칠근 단독추출물, 또는 숙지황과 삼칠근 혼합 추출물은 물, C1~C3의 알코올 또는 물과 C1~C3의 알코올 혼합용매로 추출되는 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제4항에 있어서, 상기 알코올은 메탄올 또는 에탄올인 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 치주질환 예방 및 치료는 종양괴사인자 분비 억제에 의한 것임을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 치주질환 예방 및 치료는 오스테오프로테게린(OPG) 분비 촉진에 의한 것임을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 치주질환은 치은염인 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 치주질환은 치주염인 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제1항에 있어서, 상기 약학적 조성물은 구강용 조성물인 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 제10항에 있어서, 상기 구강용 조성물은 치약, 구강청정제 및 구강세정제로 이루어지는 군으로부터 선택되는 1종 이상인 것을 특징으로 하는 치주질환 예방 및 치료용 약학적 조성물.
- 숙지황 단독추출물, 숙지황과 삼칠근의 단독추출물의 혼합물 또는 숙지황과 삼칠근 혼합 추출물을 유효성분으로 함유하는 치주질환 예방 및 개선용 건강 식품조성물.
- 제12항에 있어서, 상기 숙지황과 삼칠근 단독 추출물의 혼합물은 숙지황 단독추출물 1~16 중량부에 대하여 삼칠근 16~1 중량부인 것을 특징으로 하는 치주질환 예방 및 개선용 건강 식품조성물.
- 제12항에 있어서, 상기 숙지황과 삼칠근의 혼합추출물을 숙지황 1 중량부에 대하여 삼칠근 8 중량부의 비율로 혼합하여 추출한 것을 특징으로 하는 치주질환 예방 및 개선용 건강 식품조성물.
- 제12항에 있어서, 상기 숙지황 또는 삼칠근 단독추출물, 또는 숙지황과 삼칠근 혼합 추출물은 물, C1~C3의 알코올 또는 물과 C1~C3의 알코올 혼합용매로 추출되는 것을 특징으로 하는 치주질환 예방 및 개선용 건강 식품조성물.
- 제15항에 있어서, 상기 알코올은 메탄올 또는 에탄올인 것을 특징으로 하는 치주질환 예방 및 개선용 건강 식품조성물.
- 제12항에 있어서, 상기 치주질환은 치은염인 것을 특징으로 하는 치주질환 예방 및 개선용 건강 식품조성물.
- 제12항에 있어서, 상기 치주질환은 치주염인 것을 특징으로 하는 치주질환 예방 및 개선용 건강 식품조성물.
Priority Applications (6)
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KR1020070037997A KR100852881B1 (ko) | 2007-04-18 | 2007-04-18 | 숙지황, 삼칠근 또는 이들의 혼합 추출물을 유효성분으로함유하는 치주질환 예방 및 치료용 조성물 |
US12/596,014 US20100129476A1 (en) | 2007-04-18 | 2008-04-04 | Composition comprising rehmanniae radix preparata, notoginseng radix or mixture extract thereof for preventing and treating of periodontitis as an effective component |
CN200880012373.3A CN101657209B (zh) | 2007-04-18 | 2008-04-04 | 用于预防和治疗牙周炎的包含熟地黄、三七或其混合物提取物作为有效组分的组合物 |
PCT/KR2008/001924 WO2008130113A1 (en) | 2007-04-18 | 2008-04-04 | Composition comprising rehmanniae radix preparata, notoginseng radix or mixture extract thereof for preventing and treating of periodontitis as an effective component |
JP2010503962A JP5427772B2 (ja) | 2007-04-18 | 2008-04-04 | 有効な成分としての、歯周炎の予防および治療のための熟地黄、三七根またはそれの抽出物の混合物を含む組成物 |
EP08741174A EP2139506A4 (en) | 2007-04-18 | 2008-04-04 | COMPOSITION BASED ON REHMANNIAE RADIX PREPARATA, NOTOGINSENG RADIX, OR CERTAIN EXTRACTS AND MIXTURES, FOR THE PREVENTION AND TREATMENT OF PERIODONTITIS |
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KR1020070037997A KR100852881B1 (ko) | 2007-04-18 | 2007-04-18 | 숙지황, 삼칠근 또는 이들의 혼합 추출물을 유효성분으로함유하는 치주질환 예방 및 치료용 조성물 |
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KR1020070037997A KR100852881B1 (ko) | 2007-04-18 | 2007-04-18 | 숙지황, 삼칠근 또는 이들의 혼합 추출물을 유효성분으로함유하는 치주질환 예방 및 치료용 조성물 |
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US (1) | US20100129476A1 (ko) |
EP (1) | EP2139506A4 (ko) |
JP (1) | JP5427772B2 (ko) |
KR (1) | KR100852881B1 (ko) |
CN (1) | CN101657209B (ko) |
WO (1) | WO2008130113A1 (ko) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20160124007A (ko) * | 2015-04-17 | 2016-10-26 | 주식회사유한양행 | 염증성 질환 또는 통증 예방 또는 치료용 조성물 |
KR20210039068A (ko) | 2019-10-01 | 2021-04-09 | 동의대학교 산학협력단 | 미역 추출물을 유효성분으로 포함하는 치주질환의 예방 및 치료용 조성물 |
CN113841658A (zh) * | 2021-10-13 | 2021-12-28 | 昆明医科大学 | 一种牙周炎模型的快速建立方法及治疗药物 |
KR20240013871A (ko) | 2022-07-23 | 2024-01-30 | 곽도훈 | 고 순도 용융소금으로 획득한 염화나트륨과 지치 추출물을 필수성분으로 하는 페이스트치약 조성물 |
Families Citing this family (4)
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ES2699463T3 (es) * | 2009-08-04 | 2019-02-11 | Cognis Ip Man Gmbh | Extractos vegetales como aditivos para productos horneados leudados con levadura |
CN103263375B (zh) * | 2013-05-30 | 2015-09-09 | 云南七丹药业股份有限公司 | 一种含三七提取物的漱口水及其制备方法 |
JP7290906B2 (ja) | 2015-02-13 | 2023-06-14 | ロート製薬株式会社 | 歯根膜再生剤及びその製造方法 |
AU2016405343A1 (en) * | 2016-05-18 | 2017-12-07 | Nippon Zettoc Co., Ltd. | Oral composition |
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CN1428150A (zh) * | 2000-05-18 | 2003-07-09 | 彭勇军 | 护齿品3 |
JP2006022054A (ja) * | 2004-07-08 | 2006-01-26 | Wakunaga Pharmaceut Co Ltd | 口腔用組成物 |
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KR100661398B1 (ko) * | 2005-02-18 | 2006-12-27 | 주식회사 오스코텍 | 큰느타리버섯, 오가피 및 삼칠근의 혼합 생약재 추출물 및이를 유효성분으로 함유하는 치주질환 예방 및 치료용 조성물 |
KR100680628B1 (ko) * | 2005-02-23 | 2007-02-09 | 주식회사 오스코텍 | 숙지황과 오가피의 혼합 생약재 추출물 및 이를 유효성분으로 하는 골다공증 예방 및 치료용 조성물 |
CN1325080C (zh) * | 2005-03-09 | 2007-07-11 | 夏汉平 | 一种治疗牙痛的中药及其制法 |
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- 2008-04-04 EP EP08741174A patent/EP2139506A4/en not_active Withdrawn
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KR20160124007A (ko) * | 2015-04-17 | 2016-10-26 | 주식회사유한양행 | 염증성 질환 또는 통증 예방 또는 치료용 조성물 |
KR102543158B1 (ko) * | 2015-04-17 | 2023-06-14 | 주식회사유한양행 | 염증성 질환 또는 통증 예방 또는 치료용 조성물 |
KR20210039068A (ko) | 2019-10-01 | 2021-04-09 | 동의대학교 산학협력단 | 미역 추출물을 유효성분으로 포함하는 치주질환의 예방 및 치료용 조성물 |
CN113841658A (zh) * | 2021-10-13 | 2021-12-28 | 昆明医科大学 | 一种牙周炎模型的快速建立方法及治疗药物 |
KR20240013871A (ko) | 2022-07-23 | 2024-01-30 | 곽도훈 | 고 순도 용융소금으로 획득한 염화나트륨과 지치 추출물을 필수성분으로 하는 페이스트치약 조성물 |
Also Published As
Publication number | Publication date |
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CN101657209A (zh) | 2010-02-24 |
WO2008130113A1 (en) | 2008-10-30 |
CN101657209B (zh) | 2014-01-01 |
JP5427772B2 (ja) | 2014-02-26 |
EP2139506A1 (en) | 2010-01-06 |
JP2010524921A (ja) | 2010-07-22 |
US20100129476A1 (en) | 2010-05-27 |
EP2139506A4 (en) | 2011-12-07 |
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