KR100837265B1 - 조직 공학 및 조직 재생을 위한 조직 형성 세포들을 기계적으로 자극하는 방법 - Google Patents

조직 공학 및 조직 재생을 위한 조직 형성 세포들을 기계적으로 자극하는 방법

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Publication number
KR100837265B1
KR100837265B1 KR1020037008187A KR20037008187A KR100837265B1 KR 100837265 B1 KR100837265 B1 KR 100837265B1 KR 1020037008187 A KR1020037008187 A KR 1020037008187A KR 20037008187 A KR20037008187 A KR 20037008187A KR 100837265 B1 KR100837265 B1 KR 100837265B1
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KR
South Korea
Prior art keywords
tissue
cells
magnetic field
magnetic
bioreactor
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Expired - Fee Related
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KR1020037008187A
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English (en)
Korean (ko)
Other versions
KR20040028700A (ko
Inventor
알리샤 제니퍼 하피자 엘하즈
존 폴 돕슨
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킬레유니버시티
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Priority claimed from GB0031462A external-priority patent/GB0031462D0/en
Priority claimed from GB0031651A external-priority patent/GB0031651D0/en
Application filed by 킬레유니버시티 filed Critical 킬레유니버시티
Publication of KR20040028700A publication Critical patent/KR20040028700A/ko
Application granted granted Critical
Publication of KR100837265B1 publication Critical patent/KR100837265B1/ko
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Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/42—Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/06—Magnetic means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1020037008187A 2000-12-22 2001-12-19 조직 공학 및 조직 재생을 위한 조직 형성 세포들을 기계적으로 자극하는 방법 Expired - Fee Related KR100837265B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0031462.5 2000-12-22
GB0031462A GB0031462D0 (en) 2000-12-22 2000-12-22 Culturing tissue
GB0031651.3 2000-12-23
GB0031651A GB0031651D0 (en) 2000-12-23 2000-12-23 Culturing tissue
US26703201P 2001-02-07 2001-02-07
US60/267,032 2001-02-07
PCT/GB2001/005606 WO2002051985A2 (en) 2000-12-22 2001-12-19 Culturing tissue using magnetically generated mechanical stresses

Publications (2)

Publication Number Publication Date
KR20040028700A KR20040028700A (ko) 2004-04-03
KR100837265B1 true KR100837265B1 (ko) 2008-06-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037008187A Expired - Fee Related KR100837265B1 (ko) 2000-12-22 2001-12-19 조직 공학 및 조직 재생을 위한 조직 형성 세포들을 기계적으로 자극하는 방법

Country Status (8)

Country Link
EP (1) EP1343872B1 (enExample)
JP (2) JP2004520028A (enExample)
KR (1) KR100837265B1 (enExample)
CN (1) CN1250714C (enExample)
AU (1) AU2002216206B2 (enExample)
CA (1) CA2432574A1 (enExample)
NZ (1) NZ526533A (enExample)
WO (1) WO2002051985A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012118304A3 (ko) * 2011-02-28 2012-11-22 주식회사 코리아본뱅크 동종 연조직 이식체 배양 장치
KR101232554B1 (ko) * 2010-02-19 2013-02-12 연세대학교 산학협력단 자성입자의 충격자극이 가능한 물리적자극기가 통합된 세포배양장치
KR101313769B1 (ko) 2011-02-28 2013-10-01 주식회사 셀루메드 동종 연조직 이식체 배양 장치

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GB0214209D0 (en) 2002-06-19 2002-07-31 Univ Keele Method
US20040248291A1 (en) * 2003-04-10 2004-12-09 Pentax Corporation Method for culturing cells, cell culture carriers and cell culture apparatus
WO2005003332A2 (en) * 2003-06-30 2005-01-13 University Of South Florida Diamagnetically stabilised three-dimensional cell culture
US20090137018A1 (en) 2003-06-30 2009-05-28 University Of South Florida Magnetic three-dimensional cell culture apparatus and method
WO2005010139A2 (en) 2003-07-23 2005-02-03 University Of South Florida Ferromagnetic cell and tissue culture microcarriers
GB0329310D0 (en) * 2003-12-18 2004-01-21 Univ Keele Method
EP1780266A4 (en) * 2004-06-17 2009-09-09 Ken Nakata CELL CULTIVATION PROCESS WITH BIOMECHANICAL LOAD TREATMENT AND ITS DEVICE
JP4883666B2 (ja) * 2005-01-25 2012-02-22 セイコーインスツル株式会社 培養用容器及び培養用ユニット
JP4919296B2 (ja) * 2005-12-26 2012-04-18 国立大学法人大阪大学 生体形状を含んだ三次元組織の培養方法
CN101126688B (zh) * 2007-09-11 2010-05-26 深圳职业技术学院 一种规模化制备细胞显微样品的方法
DE102008059731A1 (de) * 2008-12-01 2010-06-02 Gottfried Wilhelm Leibniz Universität Hannover Verfahren und Vorrichtung zum Stimulieren von Zellen
JP2012528576A (ja) * 2009-06-03 2012-11-15 オーフス ウニベルシテット 液面下に沈める灌流バイオリアクター
WO2013047974A1 (ko) * 2011-09-27 2013-04-04 서울대학교 산학협력단 3차원 세포 배양 용구 및 이를 이용한 세포의 3차원 배양 방법
WO2015005299A1 (ja) 2013-07-09 2015-01-15 ユニバーサル・バイオ・リサーチ株式会社 培養装置、培養システム、及び培養方法
WO2015037468A1 (ja) 2013-09-12 2015-03-19 ユニバーサル・バイオ・リサーチ株式会社 培養システム、及び培養方法
KR101630017B1 (ko) * 2013-10-04 2016-06-13 동국대학교 산학협력단 자성나노입자와 전자기장을 이용한 골 재생 촉진 방법
WO2016081816A1 (en) * 2014-11-20 2016-05-26 The Johns Hopkins University System and method for conditioning of engineered tissues
IT201900018614A1 (it) * 2019-10-11 2021-04-11 Fondazione St Italiano Tecnologia Sistema e metodo di co-coltura cellulare
CN112375679B (zh) * 2020-11-17 2024-04-09 苏州大学附属第二医院 细胞周期性压力电动施加装置及施加方法
EP4574968A3 (en) 2022-03-07 2025-10-22 DEKA Products Limited Partnership Tissue maturation bioreactor systems with uniform cell distribution

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JPH05219936A (ja) * 1992-02-14 1993-08-31 Kobe Steel Ltd バイオリアクター
US5486457A (en) * 1993-08-25 1996-01-23 Children's Medical Center Corporation Method and system for measurement of mechanical properties of molecules and cells

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American J. Physiology Vol.273:E751-E758(1997) *
American J. Physiology Vol.279:C188-C194(200. 7.) *
In Vitro Cellular & Development Biology Animal Vol.35(2):87-93 (1999. 2) *
In Vitro Cellular & Development Biology Animal Vol.35(2):87-93 (1999. 2.) *
In Vitro Cellular & Development Biology Animal Vol.35(2):87-93 (1999. 2.)*
In Vitro Cellular & Development Biology Animal Vol.36(6):383-386 (2000. 6) *
In Vitro Cellular & Development Biology Animal Vol.36(6):383-386 (2000. 6.) *
In Vitro Cellular & Development Biology Animal Vol.36(6):383-386 (2000. 6.)*
J. of Biomechanics Vol.33:45-51(2000. 1.) *
Pflugers Arch-Eur J Physiol Vol.435:320-327(1998) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101232554B1 (ko) * 2010-02-19 2013-02-12 연세대학교 산학협력단 자성입자의 충격자극이 가능한 물리적자극기가 통합된 세포배양장치
WO2012118304A3 (ko) * 2011-02-28 2012-11-22 주식회사 코리아본뱅크 동종 연조직 이식체 배양 장치
KR101313769B1 (ko) 2011-02-28 2013-10-01 주식회사 셀루메드 동종 연조직 이식체 배양 장치

Also Published As

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NZ526533A (en) 2005-09-30
EP1343872A2 (en) 2003-09-17
AU2002216206B2 (en) 2007-10-04
CN1483075A (zh) 2004-03-17
WO2002051985A3 (en) 2003-01-16
CA2432574A1 (en) 2002-07-04
JP2004520028A (ja) 2004-07-08
KR20040028700A (ko) 2004-04-03
CN1250714C (zh) 2006-04-12
JP2008263986A (ja) 2008-11-06
EP1343872B1 (en) 2013-08-14
WO2002051985A2 (en) 2002-07-04

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