KR100775315B1 - Lubricating Gel Compositions for Prevention of STDSexually Transmitted Diseases and AIDS - Google Patents

Abstract

     The polymer aqueous solution (gel) made of water-soluble polymers prevents the transmission of various sexually transmitted diseases and AIDS by not only lubricating during sexual intercourse, but also by preventing the adhesion of polymer molecules adsorbed on the human body to pathogens. This sexually transmitted disease and AIDS prevention lubricating gel is manufactured by dissolving water-soluble polymers with strong adsorption on the surface of human body, such as cellulose derivatives and polyvinyl alcohol, in distilled water.

      Lubrication, gel, gel, condom, femdom, STD, STD, AIDS, AIDS, prevention, cellulose, SCMC, HEC, HPMC, polyvinyl alcohol, PVA, water soluble, polymer, aqueous solution, viscosity, barrier wall, adhesion, adsorption

Description

     Lubricating Gel Compositions for Prevention of Sexually Transmitted Diseases (STDs) and AIDS}

1 schematically shows the anti-adhesion effect (envelope effect, barrier wall effect) on the human body surface of the water-soluble polymer.
2 is a particle size distribution diagram of a blue pigment (Shinhan Corporation)
3 is a particle size distribution diagram of a purple pigment (Dong-A Pencil Institute)
Figure 4 is a view after applying the wet intact (left column), PVA gel (middle row) and SCMC gel (right column) on the vaginal piece of the pig's vagina.
FIG. 5 is a view showing after rubbing 50 times while pressing the finger with a blue pigment (first line), purple pigment (second line) and dyekike (third line) on the vaginal fragment of FIG. 4, respectively.
FIG. 6 is a view after washing the vaginal fragments of FIG. 5 with running water from a faucet or a female vaginal cleaner

* Description of the symbols for the main parts of the drawings *

1. Gonorrhea (diameter = 800nm)

2. AIDS virus (HIV) (diameter = 125 nm)

3. Human body surface

4. Water-soluble polymers adsorbed on gonorrhea (1 molecule length = 5700nm)

5. Water-Soluble Polymer Adsorbed on HIV Virus

6. Water-Soluble Polymers Adsorbed on Human Surface

7. pili, the attachment mechanism of gonorrhea

8. Adsorption point of gonorrhea, HIV and human skin

1.Silver sulfadiazines (application number special 1988-0002000),

2. Cholates and dimethylpolysiloxanes (application number 1989-009850),

3. Chlorohexidine Gluconate (Application No. 1993-0019164),

4. Short tripeptide (Application No. 10-1993-0700479),

5. Chlorhexidine salts and methylparabines (Application No. 1994-7002712),

6. Oxidase and halooxidase (Application No. 10-1995-0704478).

7. pyrimidine or triazine (Application No. 10-2004-7018812),

8.Zinc Gluconate (Application Number EP19900306054)

9.Povidone Iodine (Application Number JP9137976)

10.Sodium Dodecyl Sulfate (Application Number US19990010956)

11.Polyquaternium, Glycerin, Methylparaben, Propylparaben (Application Number US20010003043)

12.Dextrin Sulfate (Application Number GB20020005926)

     Until now, condoms have been the best way to prevent various sexually transmitted diseases and AIDS (Acquired Immune Deficiency Syndrome). Condoms, however, tend to be generally avoided because they have the disadvantage of feeling poor when worn. In order to make up for this drawback, micro-condoms, adhesive condoms, and wet condoms have been developed.

     The lubricating gel not only facilitates insertion during normal sexual intercourse, but also softens the piston movement, thus increasing the feeling of vice versa. In addition, the lubricating gel facilitates the insertion of male genitalia due to erectile dysfunction in men or vaginal dryness in women. However, conventional lubricating gel is not very helpful in preventing various sexually transmitted diseases and AIDS. Therefore, a variety of lubricant gels containing chemical fungicides have been developed for the purpose of preventing various sexually transmitted diseases and AIDS. For example, silver sulfadiazine (Application No. 1988-0002000), Cholate and Dimethylpolysiloxane (Application No. 1989-009850), Chlorohexidine Gluconate (Application No. 1993-0019164), Short tripeptide ( Application No. 10-1993-0700479), Chlorhexidine Salt and Methylparabin (Application No. 1994-7002712), Oxidase and Halooxidase (Application No. 10-1995-0704478), Pyrimidine or Triazine (Application 10-2004-7018812), Zinc Gluconate (Application Number EP19900306054), Povidone Iodine (Application Number JP9137976), Sodium Dodecyl Sulfate (Application Number US19990010956), Polyquaternium, Glycerin, Methylparaben, Propylparaben (Application Number US20010003043), Dextrin Sulfate (Application Lubricating gels containing fungicides such as Number GB20020005926) have been developed. However, these chemicals are not widely available and can cause pain by irritating the chemical-sensitive skin, especially the mucous membranes of the urethra in men.

1. Manufacture of lubricating gel that prevents direct attachment to human body surface by blocking pathogens such as condoms from accessing human body surface by using physically harmless substance rather than chemical disinfectant that is harmful to human body

Polyvinyl alcohol (PVA) is a water-soluble polymer, and due to its strong adsorption power, it is used in large quantities as a paper adhesive. It was discovered by the inventor that the aqueous solution was colorless, tasteless, odorless and irritant even when injected into the extremely sensitive male urethra. However, an aqueous solution (gel) of polyvinyl alcohol has a disadvantage of low lubricity.
Cellulose derivatives, Sodium Carboxymethyl Cellulose (SCMC), Hydroxyethyl Cellulose (HEC), and Hydroxypropyl Methyl Cellulose (HPMC) are water-soluble polymers that are harmless to humans. It is used as a viscosity increasing agent in cosmetics and cosmetics. The inventors have found that their high viscosity aqueous polymers (gels) serve as very good lubricants and that they have no irritation when injected into extremely sensitive male urethra.

     Various sexually transmitted diseases and AIDS are transmitted by the transmission of bacteria and viruses that cause them to each other through skin contact between men and women. Installing a barrier such as a condom between the skin of men and women can prevent the transmission of these pathogens, thereby preventing the transmission of sexually transmitted diseases and AIDS. However, if a polymer aqueous solution (gel) of polyvinyl alcohol or cellulose derivative is applied to the human surface in advance and has sex, the polymer molecules are already tightly adsorbed on the human surface to form a barrier like a vine (Fig. 1). It has been discovered by the inventors that it prevents the spread of sexually transmitted diseases and AIDS because they cannot access and attach to the human surface.

     The molecular structure of the water-soluble polymer in the aqueous solution is flexible and has a long chain shape, and has a myriad of three-dimensional curves, and the curves change in an instant (Fig. 1). In addition, since the water-soluble polymer of the cellulose derivative has an anion or polarity, it is also soluble in water having a polarity, and adsorbed well to a protein of a cation or polar pathogen or a human surface. As an example, Sodium Carboxymethyl Cellulose (SCMC), with molecular weight of 860,000, has an anion in aqueous solution and forms a high viscosity gel at a concentration of 2.9% by weight, the molecular length of which is 5700nm and one molecule of 3800 It consists of flexible chains (thickness = about 1.5 nm), and many of these molecules are irregularly entangled with each other to form a three-dimensional network. The average distance between the chains and the chains is assumed to be a regular three-dimensional lattice, which is 13.8 nm.

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When sexual intercourse apply the polymer solution (gel) to the genitals and men and women rub the genitals with each other, gonorrhea bacteria (diameter = 800nm) from the skin or HIV (diameter = 125nm), the pathogen of AIDS, once the polymer solution (gel) ). Then, as shown in Figure 1, the molecules of numerous water-soluble polymers with strong adsorption force are adsorbed to the surface protein of the pathogen or to the protein of pili, which is an attachment mechanism of the pathogen, and thus paralyze the attachment function of the filament and surround the pathogen. Cheaper (gel shell effect or prison effect). In addition, many water-soluble polymer molecules with strong adsorption are tightly adsorbed to proteins on the human surface at intervals of about 13.8 nm, much smaller than the size of HIV, as in adhesives, preventing the access of pathogens (gel barrier effect). Therefore, the pathogen is unable to access the surface of the human body by the shell effect and the blocking wall effect of the polymer aqueous solution (gel) and thus do not adhere to the human surface (gel prevention effect). It is similar to the phenomenon that catch balls are not attached to catch balls when catching catches or hairs on children's catch balls or catch balls. In addition, if the paint does not adhere well to the surface of moisture or if the cream is applied to the hand, it is similar to the phenomenon that the instant adhesive is easily removed by washing with water because it does not attach directly to the skin.
Specifically, the anti-adhesion effect on the pathogen of the aqueous polymer solution (gel) as described above was proved experimentally as follows. In place of the germ, the inventors use a blue pigment of 100-20,000 nm (Figure 2) and a purple pigment of 30-500 nm of particle size distribution (Figure 3) corresponding to the size of all sexually transmitted pathogens. PVA gel (9.2 wt% aqueous solution) and SCMC gel (2.9 wt% aqueous solution) were applied to the vaginal pieces of pigs using dye inks together for comparative analysis (Fig. 4), and two pigment and dye inks were placed thereon. After rubbing fifty times with each finger and pressing hard to correspond to the friction during sexual acting (Fig. 5), it was washed with running water from the tap or a vaginal washing machine (utility model registration No. 20-0419498) designed by the present inventors (Fig. 6). As shown in FIG. 6, blue pigments and purple pigments having a size of 30 nm or more penetrate the film of PVA gel and SCMC gel (three-dimensional mesh of water-soluble polymer, spacing = about 13.8 nm) despite intense friction. They were trapped in the gel rather than attached directly to them, so they were all washed away with running water. On the contrary, the dye ink, which is a molecule of 2 nm or less, was relatively freely attached to the vaginal surface by relatively freely passing through the three-dimensional mesh of the polymer, so that the water was not completely washed. On the other hand, on the vaginal surface as it is wet, the water film does not form an effective barrier against pigment particles or dye ink molecules, so very small amounts of blue pigment particles are relatively large, and very few purple pigment particles are very small. Dye ink molecules were attached directly to the bulk vaginal surface, indicating that the water was not completely washed.
Therefore, it has been demonstrated in the above experiment that particles or pathogens with a particle size of 30 nm or more cannot pass through a dense three-dimensional network composed of molecules of water-soluble polymers adsorbed on the skin. All known sexually transmitted pathogens are larger than 30 nm. HIV, the smallest known pathogen of AIDS, is 125 nm in diameter and herpes virus is 190 nm in diameter. Therefore, all sexually transmitted diseases, regardless of the type of sexually transmitted diseases can be said to be prevented by the lubricating gel for sexually transmitted diseases of the present invention.
Since the water-soluble polymers are polar in nature, they are well adsorbed on the surface of the human body or germs composed of proteins that are also polar. Therefore, the effect of preventing the adhesion of these water-soluble polymers to the human surface is not limited to the PVA or SCMC shown above. It is a general characteristic of. Therefore, other water-soluble polymers can be used for the purpose of the present invention if harmless to the human body.

     As a result, the aqueous polymer solution (gel) does not kill bacteria or viruses by chemical disinfection, but physically prevents the pathogen from attaching directly to the human body surface by the shell effect and the barrier effect of the polymer aqueous solution (gel). This pathogen, which is not directly attached to the surface of the human body and trapped in the polymer aqueous solution (gel), is easily discharged out of the human body together with the polymer aqueous solution (gel) by washing with water later.

     In general, the male genitalia's outer shell is so thick that it can't penetrate even if the germs are attached directly. In men, germs usually invade through the mucous membrane of the urethra. Inject the polymer aqueous solution (gel) deep into the urethra using a liquid injector (Utility Model Registration No. 20-0388698) designed by the inventor in the urethra into the urethra and apply the urethral mucosa to the polymer aqueous solution (gel). It is possible to prevent the pathogens contained in women's secretions from directly attaching to the urethral mucosa by the enveloping effect and the blocking wall effect on the pathogen of the gel). The urinary inlet is infiltrated deeply into the urethra inlet due to the contraction force of the urethra inflated by the injection of the gel. After the end of sexual activity, the polymer solution (gel) is simply removed by urination. Applying the aqueous polymer solution (gel) to the entire lower abdomen, including the penis, prevents the direct attachment of the pathogen to the skin by virtue of the enveloping effect and blocking wall effect of the polymer solution (gel) on the pathogen even if the pathogen touches the skin. It is easily removed by later water washing.

     On the other hand, for women, inject the polymer solution (gel) deeply into the vagina using a syringe and apply the polymer part (gel) to the vulva and the lower abdomen. This can prevent pathogens from directly attaching to the human body surface in a larger area than femdom. After the end of sexual activity, the aqueous polymer solution (gel) is neatly removed by a vaginal washing machine (Utility Model Registration No. 20-0419498) devised by the present inventors.

     Aqueous polymer solution (gel) having an anti-adhesion effect on the above pathogen is prepared by the following method.

Example 1: 100 ml of distilled water is placed in a wide glass jar. Stir slowly adding 0.5-10.0 g of water-soluble polymers (SCMC, HEC, HPMC, etc.) in powder form, and then stir for another 5-24 hours at room temperature. 5,000-100,000 Brookfield Viscosity (Brookfield Viscosity, mPa * s) of odorless, non-irritating lubricating gel. To this lubricating gel can be added 0.0-5.0% by weight of fragrances and dyes.

     Lubricating gel of the present invention having an anti-adhesion effect on the surface of the human body against pathogens can prevent the transmission of various sexually transmitted diseases and AIDS, greatly contribute to the sexual life and health of the people.

Claims (3)

     A lubricating gel composition for preventing sexually transmitted diseases and HIV, comprising 95-100% by weight of a polymer aqueous solution (gel) having an anti-adhesion effect against various sexually transmitted diseases and AIDS pathogens.      The lubricating gel composition for sexually transmitted diseases and AIDS prevention according to claim 1, wherein the polymer aqueous solution (gel) is a 0.5-10.0 wt% aqueous solution of cellulose derivatives SCMC, HEC and PMC.      The aqueous polymer solution (gel) of claim 1 is a lubricating gel composition for preventing sexually transmitted diseases and AIDS, characterized in that Brookfield viscosity at 25 degrees Celsius is 5,000-100,000.

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