CN1372974A - Exterior-applied gel contaiing lysozyme as primary component and its preparing process - Google Patents
Exterior-applied gel contaiing lysozyme as primary component and its preparing process Download PDFInfo
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- CN1372974A CN1372974A CN 01107864 CN01107864A CN1372974A CN 1372974 A CN1372974 A CN 1372974A CN 01107864 CN01107864 CN 01107864 CN 01107864 A CN01107864 A CN 01107864A CN 1372974 A CN1372974 A CN 1372974A
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Abstract
An exterior-applied gel for treating pudendal infection of woman, cleaning vagina, and disinfecting toilet appliance and bath tub is an aqueous or oily gel containing lysozyme as main component, antibacterial agent, antiviral agent, antitrichomonal agent, disinfectant, lubricant, etc. Its advantages are high effective rate up to 81.58%, no toxicity and irritation, high health-care effect and low by-effect.
Description
The invention belongs to the HCT field, is the hygienic article of a kind of maintenance and health care pudendum (especially women), and the prevention pudendum infects, and alleviates the exterior-applied gel that pudendum is uncomfortable and have lubrication.
It is the important content of modern life health care that the prevention pudendum infects.According to statistics, the married women more than 90% is subjected to the pudendum that caused by antibacterial, mycete or parasite (as infusorian) to some extent and infects; Nearly all climacteric women once had discomforts such as pudendum is dry and astringent, scorching hot, abnormal flavour, and about 70% the senile vaginitis symptom occurs; Adolescent girls and child cause that urethritis, colpitic case also are in ascendant trend on clinical statistics in recent years because pudendum infects.Pudendum infects and causes pruritus, leukorrhagia, abnormal flavour, dry and astringent, pain, even further causes genital disease and Urinary system inflammation, has seriously hindered the daily life of modern female and has given the healthy threat that brings.But the pudendum health product that are used for daily life at present extremely lack.
The objective of the invention is to study a kind of exterior-applied gel that prevents pudendum to infect, also can match with a small amount of antibacterial, antiviral agent, anti-trichomonal agent, disinfection preservative, lubricant, freshener and aromatic etc., constituting a series of is the pudendum health product of Main Ingredients and Appearance with the lysozyme.Be used to prevent bacterial vaginitis, colpitis mycotica, trichomonal vaginitis, senile vaginitis and mixed infective vaginitis, and alleviate pruritus vulvae, pain, abnormal flavour and climacteric women that above-mentioned inflammation causes because vaginal secretions reduces the vaginal dryness that causes, discomfort such as scorching hot; Improve vaginal environment, regulate vaginal secretion, remove the intravaginal antibacterial, recover the vagina self-cleaning ability, the sterilization of sanitary equipment such as also available hotel, bathtub at home, bathroom prevents spread of sexually transmitted diseases, guards against cross infection.
It is reported that lysozyme is a kind of alkaline protease that can decompose mucopolysaccharide, the polysaccharide (main component of bacteria cell wall) that its energy hydrolyzing N-acetylglucosamine and-acetylmuramic acid repeat to constitute can cause bacterolysis, also claims muramidase.Lysozyme has stable chemical property and excellent biological compatibility, and antibiotic, antiviral, promotion blood coagulation are arranged, and decomposes effects such as pus and repair tissue, share with antimicrobial drug to strengthen its effect.The present invention system is a main component with the lysozyme, and can add a small amount of ancillary drug, therefore has the effect of anti-inflammation and sterilization, cleaning vagina, elimination pruritus, removing abnormal flavour, prevention of STD.Zoopery shows that this product is nontoxic, nonirritant and sensitization, to user health, safe, harmless.Human efficiency's result of the test proves, total effective rate 81.58% does not find that untoward reaction appears in the experimenter.Characteristics such as it is effective that the present invention has prevention and health care, easy to use, acts on the length of holding time, and side effect is little, and is applied widely.Can yet be regarded as a kind of safety, health and respond well novel pudendum health product.
Technical scheme of the present invention is: lysozyme adds the main matrix that is made of water, glycerol or propylene glycol and cellulose derivative, alginate, hyaluronate sodium, chitin, starch, carrageenan, tragcanth, gelatin, carbomer, Polyethylene Glycol or polyvinylpyrrolidone etc., forms aqueous gel; Or lysozyme adds the main matrix that is made of liquid Paraffin and polyoxyethylene or fatty oil and colloid silicon or aluminium soap, zinc soap etc., the agent of formation oil-base gel.
Can also on the basis of basic comprising, add a small amount of antibacterial, antiviral agent, anti-trichomonal agent, disinfection preservative, lubricant, freshener and aromatic etc. as required.Chinese medicines such as Western medicine such as antibacterial such as clotrimazole, miconazole, terbinafine and butenafine and Radix Sophorae Flavescentis total alkaloids, Cortex Dictamni, propolis.Antiviral agent such as acyclovir, ribavirin and interferon etc.Anti-trichomonal agent such as metronidazole, tinidazole etc.Disinfection preservative such as triclosan, iodoform, potassium permanganate and boric acid etc.Lubricant such as hydrogenated cottonseed oil, castor oil hydrogenated, tween, span, Myrij, Brij and sodium lauryl sulphate etc.Freshener such as Oleum menthae, Mentholum, Borneolum Syntheticum etc.Aromatic such as Oleum thymi vulgaris, thyme oil and Herba Menthae Rotundifoliae wet goods.
Prescription of the present invention and amount ranges are: in 100 gram gels, wherein lysozyme 0.1 gram is to 5 grams, and gel-type vehicle 50 grams are to 99.9 grams.In the time of need adding other medicines, its consumption is no more than the pharmacopeia pertinent regulations.
The present invention is series of products, and its prescription and consumption are as follows:
(1) prescription of the present invention and consumption are: in 100 gram gels, and lysozyme 2.5 grams, methylcellulose 2.0 grams, glycerol 10 grams, all the other are sterilized water.
(2) prescription of the present invention and consumption are: in 100 gram gels, and lysozyme 1.5 grams, hyaluronate sodium 2.0 grams, propylene glycol 10 grams, miconazole 0.1 gram, all the other are sterilized water.
(3) prescription of the present invention and consumption are: in 100 gram gels, and lysozyme 1.0 grams, carbomer 1.0 grams, propylene glycol 10 grams, triethanolamine 1.5 grams, clotrimazole 0.1 gram, metronidazole 0.2 gram, triclosan 0.1 gram, polyoxyethylene hydrogenated Oleum Ricini 1.0 grams, Mentholum 0.005 gram, all the other are sterilized water.
(4) prescription of the present invention and consumption are: in 100 gram gels, and lysozyme 2.0 grams, paraffin oil 15 grams, polyoxyethylene 10 grams, tween 80 1.0 grams, chlorhexidine acetate 0.1 gram, alpha-interferon 1 million international units, Borneolum Syntheticum 0.003 gram, thyme oil 0.002 gram, all the other are sterilized water.
Manufacture method of the present invention: in sterilizing room, operate, by prescription of the present invention and consumption, each composition of difference weighing, stir the preparation gel-type vehicle earlier, with a small amount of sterilized water dissolving lysozyme and water-soluble components, make A liquid then, water-insoluble composition is dissolved or dispersed in glycerol, propylene glycol or the paraffin oil, make B liquid, A liquid and B liquid are added respectively in the gel-type vehicle, and the limit edged stirs, after stirring, coating-dividing sealing promptly gets exterior-applied gel of the present invention.
Embodiments of the invention:
Embodiment one
Prescription: lysozyme 2.5 grams
Glycerol 10 grams
Methylcellulose 2.0 grams
Sterilized water 85.5 grams
Preparation technology: get methylcellulose 2 grams in sterilizing room, glycerol 10 grams and 45.5 gram sterilized water mix, and stir, and make gel-type vehicle, get lysozyme 2.5 grams and be dissolved in 40 gram sterilized water, slowly add gel-type vehicle, the limit edged stirs, and stirs evenly, packing is sealed, exterior-applied gel of the present invention.
Embodiment two
Prescription: lysozyme 1.5 grams
Hyaluronate sodium 2.0 grams
Propylene glycol 10 grams
Miconazole 0.1 gram
Sterilized water 86.4 grams
Preparation technology: in sterilizing room, get hyaluronate sodium 2 gram and 50 gram sterilized water and mix stirring and make gel-type vehicle, getting lysozyme 1.5 gram is dissolved in 36.4 gram sterilized water and makes A liquid, getting miconazole 0.1 gram is dissolved in 10 gram propylene glycol and makes B liquid, A liquid and B liquid are slowly added gel-type vehicle respectively, the limit edged stirs, and stirs evenly packing, seal, exterior-applied gel of the present invention.
Embodiment three
Prescription: lysozyme 1.0 grams
Carbomer 1.0 grams
Propylene glycol 10 grams
Triethanolamine 1.5 grams
Clotrimazole 0.1 gram
Metronidazole 0.2 gram
Triclosan 0.1 gram
Polyoxyethylene hydrogenated Oleum Ricini 1.0 grams
Mentholum 0.005 gram
Sterilized water 85.1 grams
Preparation technology: in sterilizing room, get carbomer 1.0 grams, triethanolamine 1.5 grams and 60 gram sterilized water are made gel-type vehicle, get lysozyme 1 gram and metronidazole 0.2 gram and be dissolved in 25.1 gram sterilized water and make A liquid, get clotrimazole 0.1 gram, triclosan 0.1 restrains, polyoxyethylene hydrogenated Oleum Ricini 1 gram and Mentholum 0.005 gram are dissolved in 10 gram propylene glycol and make B liquid, A liquid and B liquid are slowly added the edged stirring of gel-type vehicle limit respectively, stir evenly packing, seal, exterior-applied gel of the present invention.
Embodiment four
Prescription: lysozyme 2.0 grams
Paraffin oil 15 grams
Polyoxyethylene 10 grams
Tween 80 1.0 grams
Chlorhexidine acetate 0.1 gram
Alpha-interferon 1 million international units
Borneolum Syntheticum 0.003 gram
Thyme oil 0.002 gram
Sterilized water 71.8 grams
Preparation technology: in sterilizing room, get polyoxyethylene 10 grams, paraffin oil 14 gram and 20 gram sterilized water are made gel-type vehicle, get lysozyme 2 grams and alpha-interferon 1 million international units and are dissolved in 51.8 and restrain sterilized water and make A liquid, get chlorhexidine acetate 0.1 and restrain, Tween 80 1.0 grams, Borneolum Syntheticum 0.003 gram and thyme oil 0.002 gram are dissolved in 1 gram paraffin oil and make B liquid, and A liquid and B liquid are slowly added gel-type vehicle respectively, and the limit edged stirs, stir evenly, packing is sealed, and promptly gets exterior-applied gel of the present invention.
Claims (5)
1. one kind is the exterior-applied gel of Main Ingredients and Appearance with the lysozyme, is used for the maintenance and the health care of pudendum.Base is characterised in that and contains lysozyme in the prescription, and this lysozyme can be to extract to obtain from bird class animal egg white, also can be to extract in driven, plant tissue and the secretions thereof to obtain molecular weight 10000 to 35000.The content of lysozyme is 0.1% to 5%, and the content of gel-type vehicle is 50% to 99.9%, and when adding other adjuvant, its consumption is no more than the pharmacopeia pertinent regulations.
2. according to the described exterior-applied gel of claim 1, its feature is that also the adjuvant of lysozyme and adding all dissolves or is dispersed in the gel-type vehicle.
3. according to the described exterior-applied gel of claim 1, its feature is that also gel-type vehicle can be by water, glycerol or propylene glycol and cellulose derivative, the aqueous gel that alginate, hyaluronate sodium, chitin, starch, carrageenan, tragcanth, gelatin, carbomer, Polyethylene Glycol or polyvinylpyrrolidone etc. constitute, also can be by liquid Paraffin and polyoxyethylene or fatty oil and colloid silicon or aluminium soap, the oil-base gel that zinc soap etc. constitute.
4. according to the described exterior-applied gel of claim 1, its feature also is can add a small amount of antibacterial, antiviral agent, anti-trichomonal agent, disinfection preservative, lubricant, freshener and aromatic etc. as required in the prescription.Chinese medicines such as Western medicine such as antibacterial such as clotrimazole, miconazole, terbinafine and butenafine and Radix Sophorae Flavescentis total alkaloids, Cortex Dictamni, propolis.Antiviral agent such as acyclovir, ribavirin and interferon etc.Anti-trichomonal agent such as metronidazole, tinidazole etc.Disinfection preservative such as triclosan, iodoform, potassium permanganate and boric acid etc.Lubricant such as hydrogenated cottonseed oil, castor oil hydrogenated, tween, span, Myrij, Brij and sodium lauryl sulphate etc.
5. according to the described exterior-applied gel of claim 1, its preparation technology is characterised in that and stirs the preparation gel-type vehicle earlier, dissolve lysozyme and other water-soluble components separately with an amount of sterilized water then, water-insoluble composition dissolves or is dispersed in glycerol, propylene glycol or the paraffin oil, at last, under stirring condition, the latter two are added respectively in the gel-type vehicle, stir evenly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107864 CN1372974A (en) | 2001-03-02 | 2001-03-02 | Exterior-applied gel contaiing lysozyme as primary component and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107864 CN1372974A (en) | 2001-03-02 | 2001-03-02 | Exterior-applied gel contaiing lysozyme as primary component and its preparing process |
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| CN1372974A true CN1372974A (en) | 2002-10-09 |
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| CN 01107864 Pending CN1372974A (en) | 2001-03-02 | 2001-03-02 | Exterior-applied gel contaiing lysozyme as primary component and its preparing process |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1564682A (en) * | 2001-10-09 | 2005-01-12 | 株式会社芳凯尔 | Compositions for potentiating glutatthione |
| CN100493606C (en) * | 2005-01-17 | 2009-06-03 | 张华� | Use of human lysozyme in preparing medicines for cutaneous pruritus |
| CN102240260A (en) * | 2011-05-17 | 2011-11-16 | 山东省医疗器械研究所 | Medicament for treating colpoxerosis and preparation method thereof |
| CN104436175A (en) * | 2013-09-17 | 2015-03-25 | 陈新宇 | Fowl-egg-inner-shell-membrane biological antibacterial preparation |
| CN104606095A (en) * | 2015-01-07 | 2015-05-13 | 青岛明药堂医疗股份有限公司 | Marine flower dew gel and preparation method thereof |
| CN104971076A (en) * | 2015-05-25 | 2015-10-14 | 北京中医药大学 | Stable bee venom gel agent and preparation method thereof |
| CN106729655A (en) * | 2016-11-18 | 2017-05-31 | 珠海市新辅仁药业有限公司 | A kind of bacteriostatic gel and preparation method thereof |
| CN108014140A (en) * | 2018-02-02 | 2018-05-11 | 上海哈美实业发展有限公司 | A kind of vagina mucosa antibacterial gel and preparation method thereof |
| CN108578761A (en) * | 2018-04-12 | 2018-09-28 | 西南大学 | Load the preparation method and applications of silk gum/Ago-Gel of lysozyme |
| CN108853005A (en) * | 2018-08-12 | 2018-11-23 | 浙江丽申药业股份有限公司 | Female genital tract containing superoxide dismutase repairs gel and preparation method thereof |
| CN110124096A (en) * | 2019-05-30 | 2019-08-16 | 西安交通大学 | A kind of lysozyme/hyaluronic acid plural gel and its preparation method and application |
| CN111249219A (en) * | 2018-11-30 | 2020-06-09 | 中南大学湘雅三医院 | Ear drop for treating ear canal fungus and preparation method thereof |
| US11471473B2 (en) * | 2018-06-28 | 2022-10-18 | Chemistry Rx | Compositions and methods for treating trichomonas |
-
2001
- 2001-03-02 CN CN 01107864 patent/CN1372974A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1564682A (en) * | 2001-10-09 | 2005-01-12 | 株式会社芳凯尔 | Compositions for potentiating glutatthione |
| CN1564682B (en) * | 2001-10-09 | 2013-05-01 | 株式会社芳凯尔 | Compositions for potentiating glutatthione |
| CN100493606C (en) * | 2005-01-17 | 2009-06-03 | 张华� | Use of human lysozyme in preparing medicines for cutaneous pruritus |
| CN102240260A (en) * | 2011-05-17 | 2011-11-16 | 山东省医疗器械研究所 | Medicament for treating colpoxerosis and preparation method thereof |
| CN104436175A (en) * | 2013-09-17 | 2015-03-25 | 陈新宇 | Fowl-egg-inner-shell-membrane biological antibacterial preparation |
| CN104606095A (en) * | 2015-01-07 | 2015-05-13 | 青岛明药堂医疗股份有限公司 | Marine flower dew gel and preparation method thereof |
| CN104971076A (en) * | 2015-05-25 | 2015-10-14 | 北京中医药大学 | Stable bee venom gel agent and preparation method thereof |
| CN106729655A (en) * | 2016-11-18 | 2017-05-31 | 珠海市新辅仁药业有限公司 | A kind of bacteriostatic gel and preparation method thereof |
| CN108014140A (en) * | 2018-02-02 | 2018-05-11 | 上海哈美实业发展有限公司 | A kind of vagina mucosa antibacterial gel and preparation method thereof |
| CN108578761A (en) * | 2018-04-12 | 2018-09-28 | 西南大学 | Load the preparation method and applications of silk gum/Ago-Gel of lysozyme |
| US11471473B2 (en) * | 2018-06-28 | 2022-10-18 | Chemistry Rx | Compositions and methods for treating trichomonas |
| CN108853005A (en) * | 2018-08-12 | 2018-11-23 | 浙江丽申药业股份有限公司 | Female genital tract containing superoxide dismutase repairs gel and preparation method thereof |
| CN111249219A (en) * | 2018-11-30 | 2020-06-09 | 中南大学湘雅三医院 | Ear drop for treating ear canal fungus and preparation method thereof |
| CN111249219B (en) * | 2018-11-30 | 2023-08-11 | 中南大学湘雅三医院 | Ear drops for treating fungus in auditory canal and preparation method thereof |
| CN110124096A (en) * | 2019-05-30 | 2019-08-16 | 西安交通大学 | A kind of lysozyme/hyaluronic acid plural gel and its preparation method and application |
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