CN109453438A - A kind of preparation method of antibacterial anti-inflammatory sheath - Google Patents
A kind of preparation method of antibacterial anti-inflammatory sheath Download PDFInfo
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- CN109453438A CN109453438A CN201811227523.4A CN201811227523A CN109453438A CN 109453438 A CN109453438 A CN 109453438A CN 201811227523 A CN201811227523 A CN 201811227523A CN 109453438 A CN109453438 A CN 109453438A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/084—Carbon; Graphite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
Abstract
The present invention relates to composite material and medicine and hygiene fields, specially a kind of preparation method of antibacterial anti-inflammatory sheath.Ceramide, Squalene, decanoylacetaldehyde sodium hydrosulfite, chitosan are successively added in pure water under stiring first, warm is lowered and the state being completely dissolved is made.Then the graphene for purifying clean high-specific surface area is added thereto, high speed shear is dispersed under low temperature, and graphene-based compositional liquor is made.After mixing by compositional liquor and latex finally, sheath is made by dipping, the compositional liquor after then sheath being sprayed or being extracted again a dilution.Compared with existing product, sheath of the present invention is safe and reliable, and antibacterial anti-inflammatory does not cause drug resistance.
Description
Technical field
The present invention relates to composite material and medicine and hygiene fields, specially a kind of preparation method of antibacterial anti-inflammatory sheath.
Background technique
Sheath is the physical isolation contraceptive device that kind of meeting touches vagina, and the optimal environment of the vagina of normal female is
Faintly acid, pH≤4.5, mostly 3.8~4.4.Vaginal pH can change when with colpitis, the variation of value and cause inflammation
Pathogen it is closely related.And environmental pH and inflammation can with reciprocal causation, when such as suffering from trichomonas or bacterial vaginitis,
The pH value of leukorrhea rises, and can be greater than 5~6, the change of vaginal pH occurs.And the raising of vaginal pH, meta-alkali is such as commonly used
Property washing product clean vulva, thus inhibit and kill Bacillus acidi lactici；Excessive sexual intercourse causes pH value for 7.2~7.8 sperm residual
Intravaginal will lead to pathogenic anaerobic bacteria and Gartner bacterium mass propagation, cause microecology in vaginas unbalance of system；On the market mostly
Lubricant in number sheath is the methyl-silicone oil of meta-alkalescence.It is not strong using this sheath and human body affinity, lead to vagina
Acid-base balance is destroyed, while silicone oil is there are also the properties such as not volatile, not soluble in water, and not easy cleaning after use can make one to generate strong
Strong greasy feeling buries the seed of trouble to cause genital system diseases.
Decanoylacetaldehyde sodium hydrosulfite is kind of a yellow oily liquid.Have to Bacillus influenzae, drug-resistant staphylococcus aureus, tubercle bacillus etc.
Certain inhibiting effect, and leucocyte phagocytic activity and raising serum interleukin in energy reinforcement, are used for antiphlogistic antibacterial.To influenza bar
Bacterium, drug-resistant staphylococcus aureus, tubercle bacillus etc. have certain inhibiting effect, it can also be used to chronic cervicitis, adnexitis, infantile pneumonia.Have
External application piece treats cervicitis.But its is not soluble in water, limits its use in sheath is compound.Squalene can be to treatment glycosuria
Disease, ephritis, female endocrine dyscrasia, male sexual dysfunction have specific effect, and ceramide has moisturizing and senile-resistant efficacy
Outside, there are also barriers and anti-allergic effects.
How by decanoylacetaldehyde sodium hydrosulfite not soluble in water, Squalene in conjunction with the advantages of the ceramide of strong hydrophilicity
Get up, in compound sheath technique, making it in sexual life in use, not only meet contraception, but also vagina can be lubricated, mitigate and rub
Damage, at the same can also antibacterial anti-inflammatory, this is one of condom development good direction.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation methods of antibacterial anti-inflammatory sheath, in order to make sheath in sexual life
In use, not only met contraception, but also maintenance vagina can be moistened, increase lubrication, mitigate frictionally damage, while can also antibacterial anti-inflammatory.
The present invention is on the basis of many experiments, successfully by the mind of decanoylacetaldehyde sodium hydrosulfite not soluble in water, Squalene and strong hydrophilicity
Combine through the advantages of amide, in compound sheath technique.
The technical scheme is that
A kind of preparation method of antibacterial anti-inflammatory sheath, includes the following steps:
(1) by ceramide, Squalene, the above-mentioned biology of decanoylacetaldehyde sodium hydrosulfite, chitosan extract element according to
Secondary to be added in pure water under stiring, warm lowers the state being completely dissolved that is made, and forms glue；
(2) graphene powder for purifying clean high-specific surface area is added in glue, stone is made in ultrasonic disperse under low temperature
Black alkene and each biology extract the compositional liquor of element；
(3) after mixing by compositional liquor and latex, sheath is made by dipping；
(4) compositional liquor is diluted, compound sheath is extracted wherein, or compositional liquor is sprayed at condom surface.
The preparation method of the antibacterial anti-inflammatory sheath, ceramide, decanoylacetaldehyde sodium hydrosulfite, take off Squalene
After acetyl chitin, pure water are with 1~5:0.1 of mass ratio~1:1~5:1~10:100 mixed configuration, stirring warm modulated.
The preparation method of the antibacterial anti-inflammatory sheath, 60~120r/min of mixing speed, in 30~40 DEG C of modulateds
Then 60~80min continues heat preservation 60~120min of modulation, the glue being completely dissolved under the conditions of 50~60 DEG C.
The preparation method of the antibacterial anti-inflammatory sheath, chitosan be when deacetylation is 45~55%,
The hyaluronic acid-like chitosan of water can be dissolved in.
The preparation method of the antibacterial anti-inflammatory sheath, the graphene for purifying clean high-specific surface area is water-soluble carboxyl
Base graphite alkene powder, piece diameter size are distributed as 0.5~5 μm, 200~1000m of specific surface area2/ g, the mass ratio with pure water are
0.5~5:100.
The preparation method of the antibacterial anti-inflammatory sheath, the purity of water-soluble carboxylated graphene powder are greater than
99.9wt%.
The preparation method of the antibacterial anti-inflammatory sheath, graphene powder is added in glue, then at 0~5 DEG C, surpasses
Sound disperses 30~60min.
The preparation method of the antibacterial anti-inflammatory sheath, when compositional liquor dilutes, the compositional liquor of graphene and glue is being stirred
Pure water is added under the conditions of mixing, gradually dilutes, adjusts viscosity to 100~1000mPas.
The preparation method of the antibacterial anti-inflammatory sheath, the compositional liquor after dilution are sprayed at the condom surface, or leaching
It proposes mode and forms adhesive layer in compound condom surface.
The preparation method of the antibacterial anti-inflammatory sheath mixes compositional liquor with latex example 1:1~20 in mass ratio
After even, sheath is made by dipping.
Unique design thought of the invention is:
The present invention is firm by decanoylacetaldehyde sodium hydrosulfite not soluble in water and Squalene using hydrophilic carboxylated graphene
Jail absorption, using the powerful specific surface area of graphene to the strong adsorption capacity of oily matter, the hydrophilic end face of graphene again can be with for this
With the ceramide and chitosan strong adsorption of strong hydrophilicity.It is final to realize carboxylated graphene by ceramide, shark shark
Alkene, decanoylacetaldehyde sodium hydrosulfite, chitosan are unified in its surrounding materials.Then mixed with aqueous natural gum lotion
It closes, prepares compound sheath.
Ceramide provides moisturizing and anti-allergic effects, and Squalene adjusts men and women's incretion balance, decanoyl acetaldehyde sulfurous acid
For hydrogen sodium to the healing of cervicitis and to the resistant of bacterial virus, chitosan also has preferable antibacterial activity, can inhibit
The growth and breeding of some fungies, bacterium and virus.Carboxylated graphene is not only the carrier of above-mentioned biomass simultaneously, sharp
There are killing and inhibiting effect in edge to any bacterium being in contact with it.It is anti-that this physical killing inhibition will not allow bacterium to generate
Property.So carboxylated graphene has very good lasting broad spectrum antibacterial.
Finally, the biomass of two kinds of oil, water physical property is uniformly combined in latex condom, safe and reliable, nonreactive is realized
The preparation of the graphene-based antibacterial anti-inflammatory sheath of pharmacological property.
It advantages of the present invention and has the beneficial effect that:
1, compared with common sheath, product of the present invention is by carboxylated graphene hydrophily to the appearance of hydrophilic biomass
The strong suction-operated of load and bigger serface to oleophylic biomass realizes that two kinds of physical property substances are uniform multiple in water-based latex
It closes.
2, compared with common sheath, product of the present invention sufficiently realizes contraception in performance, lubricates reproductive organs, mitigates
Frictionally damage, while can also the Multifunctional effects such as antibacterial anti-inflammatory.
3, compared with existing similar product, product of the present invention surface is biocompatibility based on nontoxic bio-extract
It is good, securely and reliably, it is not likely to produce allergy, the sexual life of pregnant woman or lactating female is also suitble to use.
Specific embodiment
In the specific implementation process, the preparation method of antibacterial anti-inflammatory sheath of the present invention, first by ceramide, shark shark
Alkene, decanoylacetaldehyde sodium hydrosulfite, chitosan are successively added in pure water under stiring, and warm downward is made completely molten
The state of solution.Then the graphene for purifying clean high-specific surface area is added thereto, high speed shear is dispersed under low temperature, and stone is made
The compositional liquor of mertenyl.After mixing by compositional liquor and latex finally, sheath is made by dipping, then again by sheath
Compositional liquor after a time dilution of spraying or extraction.This method is mainly in two stages: first stage be by graphene with
Compositional liquor is made in the mixing of biomass extract composite glue solution, ultrasonic disperse.Then after being mixed with Heveatex, by normal process
Prepare compound sheath.Second stage is dilution compositional liquor to appropriate viscosity, allows to be sprayed at the condom surface,
Or leaching mode forms the adhesive layer for strengthening antibacterial anti-inflammatory in compound condom surface.
The present invention is described in detail combined with specific embodiments below.
Embodiment 1
In the present embodiment, by 1g ceramide, 0.5g Squalene, 3g decanoylacetaldehyde sodium hydrosulfite, the deacetylated crust of 3g
Element is added sequentially in 100g pure water, is mixed with the mixing speed of 120r/min, after 40 DEG C are stirred 1 hour, continues to be warming up to 50
DEG C 120min is stirred and modulated, be completely dissolved state at this time, forms glue.1 μm of piece diameter purifying is clean, specific surface area 800m2/
The graphene powder 0.5g (purity is greater than 99.9wt%) of g, is added in glue.At 3 DEG C of low temperature, ultrasonic disperse 60min is made
Graphene and each biology extract the compositional liquor of element.Finally compositional liquor and latex example 1:10 in mass ratio after mixing, are passed through
Compound sheath is made in normal impregnation technology.
Compositional liquor is slowly added to after pure water is diluted to viscosity 500mPas, compound sheath is extracted one time wherein,
Or compositional liquor is sprayed at graphene surface, it can be completed.
1 sample of embodiment is inspected by random samples, referring to " GB15979-2002 Disposable Sanitary Accessory sanitary standard " and " QB/T
The evaluation method of 2738-2012 daily chemical products antibacterial bacteriostatic effect " standard testing: bacteria colony count 12, vaginal mucosa irritation
Test and Skin allergy test be normal through.It is 86% to golden yellow grape bacillus test antibiotic rate, to green pus bar
The bacteriostasis rate of bacterium test is 91%.Clinical trial cures cycle time 10% to the treatment of womb inflammation.
Embodiment 2
In the present embodiment, by 2g ceramide, 0.5g Squalene, 2g decanoylacetaldehyde sodium hydrosulfite, the deacetylated crust of 2g
Element is added sequentially in 100g pure water, is mixed with the mixing speed of 120r/min, after 30 DEG C are stirred 1 hour, continues to be warming up to 60
DEG C 120min is stirred and modulated, be completely dissolved state at this time, forms glue.2 μm of piece diameter purifying are clean, specific surface area
1000m2The graphene powder 0.5g (purity is greater than 99.9wt%) of/g, is added in glue.At 3 DEG C of low temperature, ultrasonic disperse
60min, is made graphene and each biology extracts the compositional liquor of element.Finally compositional liquor is mixed with latex example 1:5 in mass ratio
After even, compound sheath is made by normal impregnation technology.
Compositional liquor is slowly added to after pure water is diluted to viscosity 400mPas, compound sheath is extracted one time wherein,
Or compositional liquor is sprayed at graphene surface, it can be completed.
2 sample of embodiment is inspected by random samples, referring to " GB 15979-2002 Disposable Sanitary Accessory sanitary standard " and " QB/
The evaluation method of T 2738-2012 daily chemical products antibacterial bacteriostatic effect " standard testing: bacteria colony count 10, vagina mucosa thorn
Swash test and Skin allergy test be normal through.It is 89% to golden yellow grape bacillus test antibiotic rate, to green pus
The bacteriostasis rate of bacillus test is 90%.Clinical trial cures cycle time 9% to the treatment of womb inflammation.
Embodiment 3
In the present embodiment, by 3g ceramide, 0.5g Squalene, 3g decanoylacetaldehyde sodium hydrosulfite, the deacetylated crust of 3g
Element is added sequentially in 100g pure water, is mixed with the mixing speed of 120r/min, after 30 DEG C are stirred 1 hour, continues to be warming up to 60
DEG C 120min is stirred and modulated, be completely dissolved state at this time, forms glue.1 μm of piece diameter purifying is clean, specific surface area 700m2/
The graphene powder 1g (purity is greater than 99.9wt%) of g, is added in glue.At 4 DEG C of low temperature, stone is made in ultrasonic disperse 60min
Black alkene and each biology extract the compositional liquor of element.Finally after mixing by compositional liquor and latex example 1:15 in mass ratio, by just
Compound sheath is made in normal impregnation technology.
Compositional liquor is slowly added to after pure water is diluted to viscosity 600mPas, compound sheath is extracted one time wherein,
Or compositional liquor is sprayed at graphene surface, it can be completed.
3 sample of embodiment is inspected by random samples, referring to " GB 15979-2002 Disposable Sanitary Accessory sanitary standard " and " QB/
The evaluation method of T 2738-2012 daily chemical products antibacterial bacteriostatic effect " standard testing: bacteria colony count 10, vagina mucosa thorn
Swash test and Skin allergy test be normal through.It is 90% to golden yellow grape bacillus test antibiotic rate, to green pus
The bacteriostasis rate of bacillus test is 93%.Clinical trial cures cycle time 12% to the treatment of womb inflammation.
Embodiment the result shows that, the present invention adsorbs a variety of bio-extracts using graphene, and compounded natural rubber latex preparation is new
The compound sheath of type generates bactericidal function.Compared with existing product, sheath of the present invention is safe and reliable, antibacterial anti-inflammatory, no
Cause drug resistance.
Claims (10)
1. a kind of preparation method of antibacterial anti-inflammatory sheath, feature is as follows, includes the following steps:
(1) ceramide, Squalene, decanoylacetaldehyde sodium hydrosulfite, the above-mentioned biology of chitosan are extracted element and successively existed
It is added with stirring in pure water, warm lowers the state being completely dissolved that is made, and forms glue；
(2) graphene powder for purifying clean high-specific surface area is added in glue, graphene is made in ultrasonic disperse under low temperature
The compositional liquor of element is extracted with each biology；
(3) after mixing by compositional liquor and latex, sheath is made by dipping；
(4) compositional liquor is diluted, compound sheath is extracted wherein, or compositional liquor is sprayed at condom surface.
2. the preparation method of antibacterial anti-inflammatory sheath described in accordance with the claim 1, feature is as follows, ceramide, Squalene,
Decanoylacetaldehyde sodium hydrosulfite, chitosan, pure water are matched with 1~5:0.1 of mass ratio~1:1~5:1~10:100 mixing
It postpones, stirring warm modulated.
3. the preparation method of antibacterial anti-inflammatory sheath according to claim 2, feature is as follows, mixing speed 60~
120r/min, in 30~40 DEG C of 60~80min of modulated, then continue under the conditions of 50~60 DEG C heat preservation modulation 60~
120min, the glue being completely dissolved.
4. the preparation method of antibacterial anti-inflammatory sheath according to claim 2, feature is as follows, and chitosan is to work as
When deacetylation is 45~55%, the hyaluronic acid-like chitosan of water can be dissolved in.
5. the preparation method of antibacterial anti-inflammatory sheath described in accordance with the claim 1, feature is as follows, purifies clean Gao Bibiao
The graphene of area is water-soluble carboxylated graphene powder, and piece diameter size is distributed as 0.5~5 μm, specific surface area 200~
1000m2/ g, the mass ratio with pure water are 0.5~5:100.
6. the preparation method of antibacterial anti-inflammatory sheath according to claim 5, feature is as follows, water-soluble carboxylated graphite
The purity of alkene powder is greater than 99.9wt%.
7. the preparation method of antibacterial anti-inflammatory sheath described in accordance with the claim 1, feature is as follows, and glue is added in graphene powder
In liquid, then at 0~5 DEG C, 30~60min of ultrasonic disperse.
8. the preparation method of antibacterial anti-inflammatory sheath described in accordance with the claim 1, feature is as follows, when compositional liquor dilutes, stone
Pure water is added in the compositional liquor of black alkene and glue under agitation, gradually dilutes, and adjusts viscosity to 100~1000mPas.
9. the preparation method of antibacterial anti-inflammatory sheath according to claim 8, feature is as follows, the compositional liquor spray after dilution
It is applied to the condom surface or leaching mode and forms adhesive layer in compound condom surface.
10. the preparation method of antibacterial anti-inflammatory sheath described in accordance with the claim 1, feature is as follows, by compositional liquor and latex
After mixing, sheath is made by dipping in example 1:1~20 in mass ratio.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811227523.4A CN109453438A (en) | 2018-10-22 | 2018-10-22 | A kind of preparation method of antibacterial anti-inflammatory sheath |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811227523.4A CN109453438A (en) | 2018-10-22 | 2018-10-22 | A kind of preparation method of antibacterial anti-inflammatory sheath |
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| CN109453438A true CN109453438A (en) | 2019-03-12 |
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| CN201811227523.4A Pending CN109453438A (en) | 2018-10-22 | 2018-10-22 | A kind of preparation method of antibacterial anti-inflammatory sheath |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638746A (en) * | 2019-09-10 | 2020-01-03 | 湖南莱博赛医用机器人有限公司 | Antibacterial and bacteriostatic hydrogel, preparation method thereof and condom |
| CN112807495A (en) * | 2021-01-18 | 2021-05-18 | 吉安丽姝科技有限公司 | Preparation method of condom with antibacterial and anti-inflammatory effects |
-
2018
- 2018-10-22 CN CN201811227523.4A patent/CN109453438A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638746A (en) * | 2019-09-10 | 2020-01-03 | 湖南莱博赛医用机器人有限公司 | Antibacterial and bacteriostatic hydrogel, preparation method thereof and condom |
| CN112807495A (en) * | 2021-01-18 | 2021-05-18 | 吉安丽姝科技有限公司 | Preparation method of condom with antibacterial and anti-inflammatory effects |
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