KR20080075240A - Urethral condoms and liquid femidoms - Google Patents

Abstract

A lubricating gel composition is provided to prevent infection of various venereal disease and AIDS by preventing pathogens from being adhered to the human surface, thereby contributing to sex life and health of people. A lubricating gel composition which is able to be injected into male urethra and female vagina for preventing venereal disease and AIDS comprises 90-100 wt.% of an aqueous solution of polymer capable of preventing pathogens from being adhered to the human surface, wherein the aqueous solution of polymer comprises 1-10 wt.% of a cellulose derivative such as sodium carboxymethyl cellulose(SCMC), hydroxyethyl cellulose(HEC) and hydroxypropyl methyl cellulose(HPMC) or 0-30 wt.% of polyvinyl alcohol.

Description

     Urethral Condoms and Liquid Femidoms

1.Silver sulfadiazines (application number special 1988-0002000),

2. Cholates and dimethylpolysiloxanes (application number 1989-009850),

3. Chlorohexidine Gluconate (Application No. 1993-0019164),

4. Short tripeptide (Application No. 10-1993-0700479),

5. Chlorhexidine salts and methylparabines (Application No. 1994-7002712),

6. Oxidase and halooxidase (Application No. 10-1995-0704478).

7. pyrimidine or triazine (Application No. 10-2004-7018812),

8.Zinc Gluconate (Application Number EP19900306054)

9.Povidone Iodine (Application Number JP9137976)

10.Sodium Dodecyl Sulfate (Application Number US19990010956)

11.Polyquaternium, Glycerin, Methylparaben, Propylparaben (Application Number US20010003043)

12.Dextrin Sulfate (Application Number GB20020005926)

13.Poloxamers (Patent Number US6,068,851)

14.Synthesis of Stable Colloidal Zirconia Sol by PVA Adsorption (Journal of Korean Association of Crystal Growth, Vol. 5, No. 2 (1995) 165-174)

     Until now, condoms have been the best way to prevent various sexually transmitted diseases and AIDS (Acquired Immune Deficiency Syndrome). Condoms, however, tend to be generally avoided because they have the disadvantage of feeling poor when worn. In order to make up for this drawback, micro-condoms, adhesive condoms, and wet condoms have been developed.

     The lubricating gel not only facilitates insertion during normal sexual intercourse, but also softens the piston movement, thus increasing the feeling of vice versa. In addition, the lubricating gel facilitates the insertion of male genitalia due to erectile dysfunction in men or vaginal dryness in women. However, conventional lubricating gel is not very helpful in preventing various sexually transmitted diseases and AIDS. Therefore, a variety of lubricant gels containing chemical fungicides have been developed for the purpose of preventing various sexually transmitted diseases and AIDS. For example, silver sulfadiazine (Application No. 1988-0002000), Cholate and Dimethylpolysiloxane (Application No. 1989-009850), Chlorohexidine Gluconate (Application No. 1993-0019164), Short tripeptide ( Application No. 10-1993-0700479), Chlorhexidine Salt and Methylparabin (Application No. 1994-7002712), Oxidase and Halooxidase (Application No. 10-1995-0704478), Pyrimidine or Triazine (Application 10-2004-7018812), Zinc Gluconate (Application Number EP19900306054), Povidone Iodine (Application Number JP9137976), Sodium Dodecyl Sulfate (Application Number US19990010956), Polyquaternium, Glycerin, Methylparaben, Propylparaben (Application Number US20010003043), Dextrin Sulfate (Application Lubricating gels containing fungicides such as Number GB20020005926) have been developed. However, these chemicals are not widely available and can cause pain by irritating the chemical-sensitive skin, especially the mucous membranes in the urethra of men.

     On the other hand, unlike chemical fungicides, a method of physically blocking germs has been developed. Injecting a polymer aqueous solution called Poloxamer into the female vagina causes a mass conversion by body temperature, forming a semi-solid film like gel from the liquid state on the female vaginal surface to block germs (Patent Number US6,068,851). However, no mention was made of the lubricity of the material and how to remove the resulting film from the female vagina. It also has the disadvantage that it can't be used by men.

1. The manufacture of lubricating gel that prevents the transfer of pathogens and prevents the transfer of pathogens by washing them with physical methods that are harmless to the human body, such as condoms, rather than chemical disinfectants that are harmful to the human body.

2. Preparation of lubricating gel which is colorless, tasteless, and odorless, but has no irritation even when injected into male urethra.

     Various sexually transmitted diseases and AIDS are transmitted by the transmission of bacteria and viruses that cause them to each other through skin contact between men and women. If a barrier such as a condom is installed between the skin of men and women, there is no transmission of these pathogens, thereby preventing the transmission of sexually transmitted diseases and AIDS. However, if a highly absorbent polymer solution is applied to the human surface, a dense adsorption layer of polymer such as thorny vines is formed on the human surface, preventing pathogens from adhering to the human surface and preventing the transmission of sexually transmitted diseases and AIDS. The fact was discovered by the inventor.

     The molecular structure of the water-soluble polymer in the aqueous solution is flexible and has a long chain shape, and has a myriad of three-dimensional curves, and the curves change in an instant. In addition, since the water-soluble polymer has an anion or polarity, it is well soluble in water having polarity, and is well adsorbed to a protein of cation or polar pathogen or human surface. Sodium Carboxymethyl Cellulose (SCMC, Molecular Weight = 860,000), for example, has an anion in aqueous solution and constitutes a high viscosity gel at a concentration of 2.0% by weight, the molecular length of which is 5700 nm and one molecule It consists of 3800 flexible chains (thickness = about 1.5 nm), and many of these molecules are irregularly entangled with each other to form a three-dimensional network. The mathematically calculated average distance between the chains is a regular three-dimensional lattice, which is 16.9 nm. to be. On the other hand, polyvinyl alcohol, which has stronger adsorption force on the surface of the human body than SCMC, constitutes a high viscosity gel at a concentration of 11.6 wt%, and the average spacing between the chains (thickness = about 1.0 nm) and the chains is also a regular three-dimensional lattice. Assuming mathematical calculations, it is 9.3 nm. If the molecules of polyvinyl alcohol are adsorbed on the surface of the human body, which has a higher affinity than water, the average spacing between chains will be narrower than in solution. As a result, bacteria much larger than 9.3 nm (diameter of gonorrhea = 800 nm) or viruses (diameter of HIV = 125 nm) cannot access and adhere to the human surface.

     When sexual intercourse apply the polymer aqueous solution to the genitals, and then the sexes rub the genitals with each other, the germs that fall off the skin once falls into the polymer aqueous solution. Then, many molecules of water-soluble polymers with strong adsorption force are adsorbed on the surface protein of the pathogen or the protein of pili, which is the attachment mechanism of the pathogen, and paralyze the pathogen, and envelop the pathogen. . In addition, many water-soluble polymer molecules with strong adsorption are tightly adsorbed on the surface of the body, much like the adhesive, at much smaller intervals than the size of HIV, preventing the access of pathogens like thorns. Therefore, the pathogen does not have access to the surface of the human body due to the shell effect and the blocking wall effect of the polymer aqueous solution, and thus does not adhere to the surface of the human body (adhesion prevention effect). As a result, the polymer aqueous solution does not kill germs or viruses by chemical sterilization, but physically prevents the pathogen from adhering to the human surface by the shell effect and the barrier effect of the polymer aqueous solution. The pathogens, which are not attached to the surface of the human body and trapped in the polymer aqueous solution, are easily discharged out of the human body together with the polymer aqueous solution by washing with water later.

     In general, the male genitalia's outer shell is so thick that it can't penetrate even if the germs are attached. In men, germs usually invade through the mucous membrane of the urethra. The urethral mucosa is injected into the urethra using a liquid injector of the urethra (utility model registration No. 0388699) designed by the present inventor in the male urethra, and the urethral mucosa is coated with the polymer aqueous solution. By the wall effect, it is possible to prevent the pathogens contained in the female secretions from adhering to the urethral mucosa. Therefore, the aqueous polymer solution injected into the male urethra may be referred to as "liquid condom" or "urethral condom". The urethral inlet is gradually applied to the urethral inlet due to the contraction force of the urethra inflated by the injection of the gel. After sex, the polymer solution is neatly removed by pissing. Applying the aqueous polymer solution to the entire lower abdomen, including the penis, prevents direct adherence of the pathogen to the skin by the enveloping effect and the blocking wall effect of the pathogen, even if the pathogen touches the skin. Easily removed On the other hand, about women, inject about 10 milliliters of vaginal polymer solution into the vagina using a syringe and apply the polymer solution to the vulva and lower abdomen. It can be called "liquid femidom" because it can be protected. After the end of sexual activity, the polymer aqueous solution is neatly removed from the female vagina by a vaginal washing machine (Utility Model Registration No. 0388697) devised by the inventor.

     Polyvinyl alcohol is a water-soluble polymer, and due to its strong adsorption power, it is used in large quantities as a paper adhesive and also as a dispersant for colloidal particles (Document 14). The inventors found that the aqueous solution was colorless, tasteless, odorless and irritant even when injected into the most sensitive male urethra. However, there is a disadvantage that the lubricity is low. The cellulose derivatives, Sodium Carboxymethyl Cellulose (SCMC), Hydroxyethyl Cellulose (HEC), and Hydroxypropyl Methyl Cellulose (HPMC), are harmless water-soluble polymers. It is used as a viscosity increasing agent in cosmetics and cosmetics. Although the adsorption power is lower than that of polyvinyl alcohol, the inventors have found that their aqueous solution acts as a very good lubricant gel and that there is no irritation even when injected into extremely sensitive male urethra. Therefore, the inventors can mix the above two aqueous polymer solution to produce a sexually transmitted disease and AIDS prevention lubricating gel with good adsorption power. Therefore, the lubricating gel having the anti-adhesion effect on the above pathogen was prepared by the following method.

Example 1 72.2 g of coarse powdered polyvinyl alcohol (Dongyang Chemistry Polyvinyl Alcolol 1700) was mixed with 549 g of distilled water, followed by continuous stirring at 80-90 ° C. for about 30 minutes. %) Is generated. Meanwhile, 45.7 g of Sodium Carboxy Methyl Cellulose (SCMC, Hercules Chemicals Company Type FVH9A) in fine powder form was mixed with 1510 g of distilled water and stirred vigorously for about 1 minute. An aqueous solution in the form of a high viscosity gel (concentration = 2.54% by weight) is produced. When the polyvinyl alcohol aqueous solution and the SCMC aqueous solution are mixed at an appropriate ratio, high viscosity, colorless, tasteless, non-irritant sexually transmitted diseases with excellent lubricity and lubricity, and lubricating gel for AIDS prevention are produced.

     Lubricating gel of the present invention having an anti-adhesion effect on the surface of the human body against pathogens can prevent the transmission of various sexually transmitted diseases and AIDS will greatly contribute to the sex life and health of the people.

Claims (3)

     A lubricating gel composition for sexually transmitted diseases and AIDS prevention, which can be injected into male urethra and female vagina, characterized by containing 90-100% by weight of a polymer aqueous solution having an anti-adhesion effect by adsorption on the surface of a human body against pathogens.      The lubricating gel composition for preventing sexually transmitted diseases and AIDS of males and females, characterized in that the polymer aqueous solution contains 1-10% by weight of cellulose derivatives (SCMC, HEC and PMC).       The lubricating gel composition for preventing sexually transmitted diseases and AIDS of claim 1, wherein the aqueous polymer solution contains 0-30% by weight of polyvinyl alcohol.