KR20050080127A - Lubricating gel compositions containing colloidal silver for prevention of std(sexually transmitted diseases) and aids - Google Patents
Lubricating gel compositions containing colloidal silver for prevention of std(sexually transmitted diseases) and aids Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
콜로이드 실버(Colloidal Silver, 은용액, 은이온, 은물)가 함유된 윤활젤은 성관계시 윤활작용뿐만 아니라 콜로이드 실버의 광범위한 살균력에 의하여 각종 성병과 에이즈의 전염을 예방하게 한다. 인체에 무해한 이 윤활젤은 콜로이드 실버에 셀룰로즈유도체 수용성 고분자를 첨가하여 제조된다. Lubricating gel containing colloidal silver (silver solution, silver ions, silver water) not only lubricates during sex but also prevents the spread of various sexually transmitted diseases and AIDS by the extensive disinfecting power of colloidal silver. Harmless to humans, this lubricating gel is made by adding cellulose derivative water-soluble polymer to colloidal silver.
Description
지금까지는 각종 성병과 에이즈(AIDS, Acquired Immune Deficiency Syndrome,후천성 면역결핍증) 예방의 목적으로 콘돔을 사용하는 것이 가장 좋은 방법이었다. 그러나 콘돔은 착용할 때 성감이 저하되는 단점을 가졌기 때문에 일반적으로 기피하는 경향이 있다. 이러한 단점을 보완하기 위하여 마이크로-콘돔, 접착식 콘돔, 습윤성 콘돔 등이 개발되기도 하였다. Until now, condoms have been the best way to prevent various sexually transmitted diseases and AIDS (Acquired Immune Deficiency Syndrome). Condoms, however, tend to be generally avoided because they have the disadvantage of feeling poor when worn. In order to make up for this drawback, micro-condoms, adhesive condoms, and wet condoms have been developed.
윤활젤은 정상적인 성관계시 삽입을 용이하게 할 뿐 아니라 피스톤운동을 유연하게 하기 때문에 콘돔과는 정반대로 성감을 오히려 증대시킨다. 또한 윤활젤은 남성의 발기부전증 또는 여성의 질건조증 등으로 남성 성기의 삽입이 어려울 경우에도 이를 용이하게 한다. 그러나 통상의 윤활젤은 각종 성병과 에이즈예방에는 별로 도움이 되지 못한다. 따라서 각종 성병과 에이즈예방의 목적으로 화학약품의 살균제가 포함된 윤활젤이 여러 가지 개발되었다. 예를 들면, 실버 설파다이아진(출원번호 특1988-0002000), 콜산염과 디메틸폴리실록산 (출원번호 특1989-009850), 클로로헥시딘글루코네이트 (출원번호 특1993-0019164), 짧은 트리펩티드(출원번호 10-1993-0700479), 크로르헥시딘소금과 메틸파라빈 (출원번호 특1994-7002712), 옥시다제와 할로옥시다제(출원번호 10-1995-0704478), 피리미딘 또는 트리아진(출원번호 10-2004-7018812), Zinc Gluconate(Application Number EP19900306054), Povidone Iodine(Application Number JP9137976), Sodium Dodecyl Sulfate(Application Number US19990010956), Polyquaternium, Glycerin, Methylparaben, Propylparaben(Application Number US20010003043), Dextrin Sulfate(Application Number GB20020005926) 등의 살균제가 함유된 윤활젤이 개발되어 있다. 그러나 이들 화학약품은 그 살균력이 콜로이드 실버(은용액, 은이온, 은물)만큼 광범위하지 못하고 화학약품에 민감한 피부, 특히 남성의 요도내의 점막을 자극하여 통증을 유발할 수 있다. The lubricating gel not only facilitates insertion during normal sexual intercourse, but also softens the piston movement, thus increasing the feeling of vice versa. In addition, the lubricating gel facilitates the insertion of male genitalia due to erectile dysfunction in men or vaginal dryness in women. However, conventional lubricating gel is not very helpful in preventing various sexually transmitted diseases and AIDS. Therefore, a variety of lubricant gels containing chemical fungicides have been developed for the purpose of preventing various sexually transmitted diseases and AIDS. For example, silver sulfadiazine (Application No. 1988-0002000), Cholate and Dimethylpolysiloxane (Application No. 1989-009850), Chlorohexidine Gluconate (Application No. 1993-0019164), Short tripeptide ( Application No. 10-1993-0700479), Chlorhexidine Salt and Methylparabin (Application No. 1994-7002712), Oxidase and Halooxidase (Application No. 10-1995-0704478), Pyrimidine or Triazine (Application 10-2004-7018812), Zinc Gluconate (Application Number EP19900306054), Povidone Iodine (Application Number JP9137976), Sodium Dodecyl Sulfate (Application Number US19990010956), Polyquaternium, Glycerin, Methylparaben, Propylparaben (Application Number US20010003043), Dextrin Sulfate (Application Lubricating gels containing fungicides such as Number GB20020005926) have been developed. However, these chemicals are not as widespread as their colloidal silver (silver solutions, silver ions, silver water) and can cause pain by irritating chemical-sensitive skin, especially the mucous membranes of the urethra in men.
금속으로서의 은은 오랜 세월 동안 광범위한 살균제로서 널리 알려져 왔다. 그러나 은을 금속 덩어리 그대로 이용하기보다는 매우 작은 입자의 형태로 물에 분산시킨 콜로이드 상태의 은이 살균제로서 가장 효과적임이 밝혀졌다. 이러한 콜로이드 실버(은용액, 은이온, 은물)는 인체에 질병을 일으키는 650여 가지의 세균 및 바이러스를 인체에 전혀 독성을 주는 일 없이 수분이내에 박멸 시킬 수 있는 능력을 가지고 있다(은을 마실 수 있다!, 김재수, 도서출판 선 미디어, 2003. 11. 10., 출원번호 10-1998-0041942, 출원번호 10-2001-0022184, 출원번호 10-2001-0067735, 출원번호 10-2002-0021398, 출원번호 20-2004-0018285 등). Silver as a metal has been widely known for a long time as a wide range of fungicides. However, it was found that colloidal silver dispersed in water in the form of very small particles is most effective as a disinfectant, rather than using silver as a metal lump. This colloidal silver (silver solution, silver ions, silver water) has the ability to eradicate more than 650 bacteria and viruses that cause disease in the body within minutes without any toxicity to the human body (you can drink silver !, Kim Jae Soo, Sun Publishing Media, Nov. 10, 2003, Application No. 10-1998-0041942, Application No. 10-2001-0022184, Application No. 10-2001-0067735, Application No. 10-2002-0021398, Application No. 20-2004-0018285 etc.).
최근 99.99퍼센트 이상의 순도를 가진 은봉을 사용하여 금속은을 증류수내에서 전기분해법으로 입자크기 2-15 나노미터(nm)와 농도 1-10ppm의 콜로이드 실버의 제조가 가능하게 되었다. 국내에서도 (주)코코실버가 가정용 콜로이드 실버의 제조장치를 개발하여 시판하고 있다. The use of silver rods with a purity of 99.99 percent or more has made it possible to produce colloidal silver with a particle size of 2-15 nanometers (nm) and a concentration of 1-10 ppm by distillation in metallic distilled water. Coco Silver Co., Ltd. has developed and marketed domestic colloidal silver manufacturing equipment in Korea.
1. 실버 설파다이아진(출원번호 특1988-0002000), 1.Silver sulfadiazines (application number special 1988-0002000),
2. 콜산염과 디메틸폴리실록산(출원번호 특1989-009850), 2. Cholates and dimethylpolysiloxanes (application number 1989-009850),
3. 클로로헥시딘글루코네이트(출원번호 특1993-0019164), 3. Chlorohexidine Gluconate (Application No. 1993-0019164),
4. 짧은 트리펩티드(출원번호 10-1993-0700479), 4. Short tripeptide (Application No. 10-1993-0700479),
5. 크로르헥시딘소금과 메틸파라빈(출원번호 특1994-7002712), 5. Chlorhexidine salts and methylparabines (Application No. 1994-7002712),
6. 옥시다제와 할로옥시다제(출원번호 10-1995-0704478). 6. Oxidase and halooxidase (Application No. 10-1995-0704478).
7. 피리미딘 또는 트리아진(출원번호 10-2004-7018812),7. pyrimidine or triazine (Application No. 10-2004-7018812),
8. Zinc Gluconate(Application Number EP19900306054)8.Zinc Gluconate (Application Number EP19900306054)
9. Povidone Iodine(Application Number JP9137976)9.Povidone Iodine (Application Number JP9137976)
10. Sodium Dodecyl Sulfate(Application Number US19990010956)10.Sodium Dodecyl Sulfate (Application Number US19990010956)
11. Polyquaternium, Glycerin, Methylparaben, Propylparaben(Application Number US20010003043)11.Polyquaternium, Glycerin, Methylparaben, Propylparaben (Application Number US20010003043)
12. Dextrin Sulfate(Application Number GB20020005926)12.Dextrin Sulfate (Application Number GB20020005926)
13. 은을 마실 수 있다!(김재수, 도서출판 선 미디어, 2003. 11. 10.), 13. You can drink silver! (Kim Jae-soo, Sun Publishing, Nov. 10, 2003),
14. 콜로이드 실버(출원번호 10-1998-0041942, 출원번호 10-2001-0022184, 출원번호 10-2001-0067735, 출원번호 10-2002-0021398, 출원번호 20-2004-0018285) 14. Colloidal Silver (Application No. 10-1998-0041942, Application No. 10-2001-0022184, Application No. 10-2001-0067735, Application No. 10-2002-0021398, Application No. 20-2004-0018285)
1. 각종 성병과 에이즈의 병원체에 대하여 광범위한 살균력을 가지는 각종 성병과 에이즈 예방용 윤활젤의 제조1. Preparation of various sexually transmitted diseases and AIDS prevention lubricating gel with a wide range of bactericidal power against various sexually transmitted diseases and AIDS pathogens
2. 인체에는 무해한, 특히 남성의 요도 점막에 자극성이 없는 각종 성병과 에이즈 예방용 윤활젤의 제조 2. Preparation of various sexually transmitted diseases and AIDS prevention lubricating gel which is harmless to human body, especially irritating to urethral mucosa of men
셀룰로즈유도체들인 나트륨 카복시메칠 셀룰로즈(Sodium Carboxymethyl Cellulose, SCMC), 하이드록시에칠 셀룰로즈(Hydroxyethyl Cellulose, HEC), 하이드록시프로필 메칠 셀룰로즈(Hydroxypropyl Methyl Cellulose, HPMC) 등은 인체에 무해한 수용성 고분자들인데 페인트, 화장품 및 의약품에 있어서 점도증가제로 쓰이고 있다. 그러나 고 점도를 가진 이들의 고분자수용액(젤)이 매우 우수한 윤활젤의 역할을 한다는 사실과 지극히 예민한 남성요도에 주입하여도 아무 자극성이 없다는 사실이 발명자에 의하여 발견되었다. Cellulose derivatives such as Sodium Carboxymethyl Cellulose (SCMC), Hydroxyethyl Cellulose (HEC), and Hydroxypropyl Methyl Cellulose (HPMC) are water-soluble polymers that are harmless to humans. It is used as a viscosity increasing agent in cosmetics and pharmaceuticals. However, the inventors have found that the polymer solution (gel) having a high viscosity acts as a very good lubricating gel and has no irritation even when injected into extremely sensitive male urethra.
수용액 내에서의 수용성 고분자의 분자구조는 유연하고 긴 사슬모양으로 되어 있어 무수히 많은 3차원의 곡선모양을 가지며 순간순간 변화무쌍하게 그 곡선모양이 변한다. 예를 들면 나트륨 카복시메칠 셀룰로즈(Sodium Carboxymethyl Cellulose, SCMC, 분자량= 860,000)는 2%의 수용액에서 고 점도의 젤을 구성하는데 그 하나의 분자길이는 5700nm이며 그 하나의 분자는 3800개의 유연한 사슬(굵기=약 1.5nm)로 이루어지며 이러한 수많은 분자들이 불규칙하게 서로 뒤엉켜 3차원 그물을 형성하는데 사슬과 사슬 사이의 평균간격을 규칙적인 3차원 격자로 가정하여 수학적으로 계산하면 16.9nm이다. The molecular structure of the water-soluble polymer in the aqueous solution is flexible and has a long chain shape, and has a myriad of three-dimensional curves, and the curves change in an instant. Sodium Carboxymethyl Cellulose (SCMC, Molecular Weight = 860,000), for example, constitutes a high viscosity gel in an aqueous solution of 2%, one molecular length of 5700 nm and one molecule of 3800 flexible chains (thickness). (About 1.5 nm) and many of these molecules are irregularly entangled with each other to form a three-dimensional network. The average distance between the chains and the chain is assumed to be a regular three-dimensional lattice, which is 16.9 nm.
전기분해법에 의하여 생성된 콜로이드 실버(은용액, 은이온, 은물)의 은입자의 크기는 2-15 나노미터(nm)이다. 따라서 이들은 고분자수용액(SCMC, 2%)의 3차원 그물(평균간격= 16.9nm)을 자유자재로 통과하여 살균작용을 할 수 있다. 또한 콜로이드 실버는 다른 화학약품의 살균제와 달라서 피부의 예민한 점막, 특히 남성의 요도 내 점막에 아무 자극성이 없음이 발명자에 의하여 발견되었다. 따라서 콜로이드 실버의 광범위한 살균력과 무자극성으로 인하여 콜로이드 실버는 본 발명의 성병과 에이즈 예방용 윤활젤에 첨가할 살균제로서 가장 적합하다고 할 수 있다. The size of silver particles of colloidal silver (silver solution, silver ions, silver water) produced by the electrolysis method is 2-15 nanometers (nm). Therefore, they can sterilize by freely passing through the three-dimensional net (mean interval = 16.9 nm) of the polymer aqueous solution (SCMC, 2%). In addition, the inventors found that colloidal silver was not irritating to the sensitive mucous membranes of the skin, especially in men's urethra, because they differ from other chemical fungicides. Therefore, due to the wide range of sterilizing power and non-irritant of colloidal silver, colloidal silver can be said to be most suitable as a disinfectant to be added to the sexually transmitted disease and AIDS prevention lubricating gel.
따라서 콜로이드 실버가 함유된 윤활젤을 남성 및 여성의 성기에 바르면 콜로이드 실버의 광범위한 살균력으로 각종 성병과 에이즈의 병원체를 수분 내에 죽임으로써 이들의 전염을 예방할 수 있다. 이러한 성병과 에이즈 예방용 윤활젤은 아래와 같은 방법으로 제조된다. Therefore, if you apply a colloidal silver-containing lubricating gel to male and female genitals, it is possible to prevent their transmission by killing various sexually transmitted diseases and AIDS pathogens in minutes with the wide range of sterilizing power of colloidal silver. These sexually transmitted diseases and AIDS prevention lubricating gel is manufactured by the following method.
실시 예1: 400ml의 증류수를 99.99퍼센트 이상의 은으로 만들어진 전극을 가진 전기분해장치(코코실버 은용액 제조기 3호)를 이용하여 입자크기 2-15nm와 농도 1-10ppm의 콜로이드 실버로 만든 후 그 중 100ml을 입구가 넓은 유리병에 담는다. 이에 분말형태의 수용성 고분자(SCMC, HEC, HPMC 등) 0.5-10.0g을 서서히 넣으면서 교반하고 그 후 계속 상온에서 5-24시간 서서히 더 교반하면 섭씨 25도에서 5,000-100,000 브룩필드점도(Brookfield Viscosity, mPa*s)의 무미, 무취, 무자극성의 윤활젤이 생성된다. 이 경우 사용하는 용기나 기구는 콜로이드 실버의 안정을 위하여 유리 또는 플라스틱제가 사용된다. Example 1: 400 ml of distilled water was made into colloidal silver having a particle size of 2-15 nm and a concentration of 1-10 ppm by using an electrolysis device (Cocosilver Silver Solution Maker No. 3) having an electrode made of 99.99 percent or more of silver. Place 100ml in a glass jar with a wide mouth. Stir slowly adding 0.5-10.0 g of water-soluble polymers (SCMC, HEC, HPMC, etc.) in powder form, and then stir for another 5-24 hours at room temperature. 5,000-100,000 Brookfield Viscosity (Brookfield Viscosity, mPa * s) tasteless, odorless, non-irritating lubricating gel. In this case, the container or utensil used is made of glass or plastic to stabilize colloidal silver.
일반적으로 남성성기의 외피는 두터워서 상처가 없으면 병균이 부착하더라도 침투하지 못한다. 남성에게는 주로 요도 내의 점막을 통해서 병균이 침입한다. 남성요도 속에 본 발명자에 의하여 고안된 요도로의 액체주입기(실용신안등록 제0388699호)를 이용하여 본 발명의 성병과 에이즈 예방용 윤활젤을 요도 깊숙이 주입하여 요도점막을 윤활젤로 도포하여 놓으면 여성의 분비물에 함유된 병원체가 요도점막에 침투되는 것을 방지할 수 있다. 요도깊이 주입된 고 점도의 윤활젤은 팽창된 요도가 수축하려는 압력으로 인하여 서서히 요도입구 쪽으로 유출되기 때문에 요도입구는 성행위 내내 윤활젤로 도포 된다. 성행위가 끝난 후 방뇨 또는 요도로의 액체주입기를 이용한 요도세척으로 윤활젤은 말끔히 제거된다. 음경 또는 하복부 전체를 윤활젤로 도포하여 놓으면 콘돔보다 더 넓은 부위를 병원체의 침입으로부터 보호할 수 있고 나중 물 세척에 의하여 쉽게 제거된다. In general, the male genitalia's outer shell is so thick that it can't penetrate even if the germs are attached. In men, germs usually invade through the mucous membrane of the urethra. The urethral fluid injector (utility model registration No. 0388699) devised by the present inventor in the urethra is injected deep into the urethra by applying the lubricating gel for preventing sexually transmitted diseases and AIDS of the present invention and applying the urethral mucosa with the lubricating gel to female secretions. The pathogens contained can be prevented from penetrating into the urethral mucosa. The high viscosity lubricating gel injected deep into the urethra is gradually discharged to the urethral inlet due to the pressure to expand the urethra, so the urethral inlet is applied as a lubricating gel throughout the sexual activity. After the end of sexual activity, the lubricating gel is neatly removed by urination or urinary rinsing using a liquid injector into the urethra. Applying a lubricating gel to the entire penis or lower abdomen can protect a wider area than the condom from invading pathogens and is easily removed by later water washing.
한편 여성에 관하여서는 주사기 등을 이용하여 질 깊이 본 발명의 성병과 에이즈 예방용 윤활젤을 충분히 주입하여 질 전체를 도포하고 외음부와 하복부 전체를 윤활젤로 도포하여 놓으면 페미돔보다 더 넓은 부위를 병원체의 침입으로부터 보호할 수 있다. 성행위가 끝난 후 본 발명자에 의하여 고안된 질세척기(실용신안등록 제0388697호)에 의하여 윤활젤은 말끔히 제거될 수 있다. On the other hand, for women, using a syringe or the like to deeply inject the sexually transmitted disease and AIDS prevention lubricating gel of the present invention to apply the entire vagina and apply the entire vulva and the lower abdomen with lubricating gel, and the area larger than femdom can be removed from invading pathogens. I can protect it. After the end of sexual activity, the lubricating gel can be neatly removed by a vaginal washing machine (Utility Model Registration No. 0388697) devised by the present inventors.
콜로이드 실버의 광범위한 살균효과를 가지는 본 발명의 윤활젤은 각종 성병과 에이즈의 전염을 예방할 수 있어 국민의 성생활과 보건에 크게 기여하게 된다. Lubricating gel of the present invention having a wide range of sterilizing effect of colloidal silver can prevent the transmission of various sexually transmitted diseases and AIDS, greatly contribute to the sexual life and health of the people.
Claims (3)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0609104-0A BRPI0609104A2 (en) | 2005-04-18 | 2006-04-13 | lubricating gel compositions, liquid injector, vaginal sprinkler |
| JP2008507542A JP2008543731A (en) | 2005-04-18 | 2006-04-13 | Urethral condoms and fluid femdomes |
| PCT/KR2006/001361 WO2006112632A1 (en) | 2005-04-18 | 2006-04-13 | Urethral condoms and liquid femidoms |
| US11/874,030 US20080078408A1 (en) | 2005-04-18 | 2007-10-17 | Urethral condoms and liquid female condoms |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20040083663 | 2004-10-19 | ||
| KR1020040083663 | 2004-10-19 |
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| Publication Number | Publication Date |
|---|---|
| KR20050080127A true KR20050080127A (en) | 2005-08-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020050063697A KR20050080127A (en) | 2004-10-19 | 2005-07-14 | Lubricating gel compositions containing colloidal silver for prevention of std(sexually transmitted diseases) and aids |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR20050080127A (en) |
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2005
- 2005-07-14 KR KR1020050063697A patent/KR20050080127A/en not_active Application Discontinuation
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